#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P00533 uniprotkb:Q6PK50 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-9356629 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356626|imex:IM-22301-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:4EC41E92601D5066|rigid:OMpQMFWRGW4zoWYhARgRa4sb73Q false sufficient binding region:1-747,750-1210("MI:0442")|flag tag:c-c("MI:0518")|mutation:750-750("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q16543 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356659|imex:IM-22301-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:E0502B034ADE54C5|rigid:7F6QedClNb3JXiZaui0MtXh2354 false sufficient binding region:1-747,750-1210("MI:0442")|mutation:750-750("MI:0118")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P00533 intact:EBI-9356686 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:q96be0_human(display_long) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356689|imex:IM-22301-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:BF83232E74109B46|rigid:9pSdc6ihhrAzTUuaEmkH0JwsKUk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518")|mutation:750-750("MI:0118")|sufficient binding region:1-747,750-1210("MI:0442") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P00533 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356718|imex:IM-22301-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:7886E7410AEEAC48|rigid:maes6BOgnQz+jbXxRWCmB2ntMmc false renilla luciferase protein tag:c-c("MI:0896") mutation:750-750("MI:0118")|flag tag:c-c("MI:0518")|sufficient binding region:1-747,750-1210("MI:0442") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q53FC7 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-9356749 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356746|imex:IM-22301-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:06FFF719D615E9C1|rigid:XoTMziA6aNLCO/r5GgR90QsSKoI false flag tag:c-c("MI:0518")|sufficient binding region:1-747,750-1210("MI:0442")|mutation:750-750("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q9BPW0 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-9356778 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356782|imex:IM-22301-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:2535BE391402803F|rigid:RO4TZhZdkxGwYXjn5AnTYKjRxWY false flag tag:c-c("MI:0518")|mutation:770-771("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P00533 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356829|imex:IM-22301-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:C9D4CA6536B84980|rigid:7F6QedClNb3JXiZaui0MtXh2354 false renilla luciferase protein tag:c-c("MI:0896") mutation:770-771("MI:0118")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q53FC7 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-9356749 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356852|imex:IM-22301-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:D6F8E963052D04DA|rigid:XoTMziA6aNLCO/r5GgR90QsSKoI false flag tag:c-c("MI:0518")|mutation:770-771("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q13451 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356807|imex:IM-22301-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:BB2B5A1207B02AFE|rigid:H6nQ1vbgT5vkrYy4+rQFKTOZkRQ false flag tag:c-c("MI:0518")|mutation:770-771("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q8IVD9 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356902|imex:IM-22301-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:4B86DEA00FEA3625|rigid:TYNaq01bJYnv4tAqvEYbEIdcRro false mutation:770-771("MI:0118")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P00533 intact:EBI-9356629 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356877|imex:IM-22301-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:6A41239B56F692E6|rigid:OMpQMFWRGW4zoWYhARgRa4sb73Q false renilla luciferase protein tag:c-c("MI:0896") mutation:770-771("MI:0118")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:P00533 intact:EBI-9356749 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:q53fc7_human(display_long) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356949|imex:IM-22301-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:929212F5C7D59703|rigid:XoTMziA6aNLCO/r5GgR90QsSKoI false renilla luciferase protein tag:c-c("MI:0896") mutation:858-858("MI:0118")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q96BE0 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-9356686 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356924|imex:IM-22301-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:2630FC8522C5FCAA|rigid:9pSdc6ihhrAzTUuaEmkH0JwsKUk false mutation:770-771("MI:0118")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00533 uniprotkb:Q16543 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356974|imex:IM-22301-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:7B158F11BB10DFFC|rigid:7F6QedClNb3JXiZaui0MtXh2354 false flag tag:c-c("MI:0518")|mutation:858-858("MI:0118") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P00533 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9356997|imex:IM-22301-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:9568F4977B218093|rigid:7F6QedClNb3JXiZaui0MtXh2354 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518")|sufficient binding region:1-30,297-1210("MI:0442") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:A2A3R6 intact:EBI-9357028 intact:EBI-9357021 psi-mi:b4dyc6_human(display_long) psi-mi:a2a3r6_human(display_long)|uniprotkb:RPS6(gene name)|psi-mi:RPS6(display_short)|uniprotkb:hCG_1741512(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357025|imex:IM-22301-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR001377(Ribosomal protein S6e)|interpro:IPR014401(Ribosomal protein S6, eukaryotic)|interpro:IPR018282|refseq:NP_001001.2|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001890"(placenta development)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007369"(gastrulation)|go:"GO:0022605"(mammalian oogenesis stage)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030425"(dendrite)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048821"(erythrocyte development)|uniprotkb:A2A3R6(identity)|human orfeome collection:4678(identity)|ddbj/embl/genbank:BC000524(identity)|entrezgene/locuslink:6194(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:beDuXCIqL99V9JlVfpzx7MdpH689606 intact-crc:1D1D2037441C318F|rigid:o9EqFmEgwiurT3IDpprlj0O9qQU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4D2J9 uniprotkb:Q9BPW0 intact:EBI-1383533 intact:EBI-9356778 psi-mi:a4d2j9_human(display_long)|uniprotkb:CAMK2B(gene name)|psi-mi:CAMK2B(display_short)|uniprotkb:tcag7.799(orf name) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357049|imex:IM-22301-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001211.3|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR032710|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:A4D2J9(identity)|entrezgene/locuslink:816(identity)|human orfeome collection:7804(identity)|ddbj/embl/genbank:BC019070(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3RDzSxLdoGtWTECo9At60gEZfZY9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:7C036C5DA86B1752|rigid:2STvRaynwA1EM2S5FcTU7fnvPJw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:A4FVC0 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9357074 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357071|imex:IM-22301-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 intact-crc:26675FBFF3A31DF5|rigid:Ft2/3DFCL3GjvU3I3tBbxnmc048 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q15773 intact:EBI-9357074 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357097|imex:IM-22301-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:E3C8F0FA996DDB07|rigid:zdKOzVU7XuVKkKSPyLniw1p0Xao false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q03933 intact:EBI-9357074 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357119|imex:IM-22301-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:7F72EB0031C48C2B|rigid:A9WjR37PtSLSZs2SykbyRflPDAM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:A4FVC0 intact:EBI-9357141 intact:EBI-9357074 psi-mi:q9hav2_human(display_long) psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357138|imex:IM-22301-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 intact-crc:DB82B62B55701827|rigid:1WvM6gBA5wHoo8xy/AQ7cAgjm14 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q8IVD9 intact:EBI-9357074 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357163|imex:IM-22301-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:C578DB143937A081|rigid:BM1d+nLoKqRW+pSZmH8AQvWJmMw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:B4DYC6 intact:EBI-9357074 intact:EBI-9357028 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357182|imex:IM-22301-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:CAD8DA90214699F3|rigid:hFiykGlnCja0gkix8wrKTqAJMgY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:A4FVC0 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9357074 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357202|imex:IM-22301-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 intact-crc:1B083C623E8E38E2|rigid:Tj9SyTs/0QHMopt8ZfAC8BH8Uss false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q96BE0 intact:EBI-9357074 intact:EBI-9356686 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357224|imex:IM-22301-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:6EBE5BCD8C298673|rigid:1V80kPOUkfhBJgedUye2JMmtxS0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:A4FVC0 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9357074 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357246|imex:IM-22301-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 intact-crc:153A4FA5C339DD4B|rigid:ps3fEiacEoqSFk4KrBXmzXfpUHY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q9BTE6-2 intact:EBI-9357074 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357292|imex:IM-22301-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:F25FCDE4B841BE0E|rigid:P6NTvGWOAiETZzQj8WOFlZn0NCI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4FVC0 uniprotkb:Q15185 intact:EBI-9357074 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:a4fvc0_human(display_long)|uniprotkb:EIF2C2(gene name)|psi-mi:EIF2C2(display_short) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357268|imex:IM-22301-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR036397|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0006417"(regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|uniprotkb:A4FVC0(identity)|ddbj/embl/genbank:BC018727(identity)|entrezgene/locuslink:27161(identity)|human orfeome collection:5907(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Noee9pQIXc18U5pxqzFZJ1lRxgs9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:2F80BD3B8A02E02C|rigid:KpV22yzLFjeg7vpFXr65ZGeDEbk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q15773 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357340|imex:IM-22301-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:0D1D7A3809743D7A|rigid:RXuDqsLXcC8mt/2B/10zav4ed88 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q15773 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357318|imex:IM-22301-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:4183755A4741D786|rigid:t7IlS5q0YTytdbWGL++fduAPdBg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q15773 intact:EBI-9356686 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q96be0_human(display_long) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357362|imex:IM-22301-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:CF1629E34994A94A|rigid:lB9TBick5THcQyqT1UsnndjKcd4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q15773 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357384|imex:IM-22301-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:D690A9D832D1588D|rigid:zDOe7hXP7uflLdrcppezo8xNRH8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:A8K251 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9357406 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:a8k251_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357409|imex:IM-22301-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:A8K251(identity)|entrezgene/locuslink:26137(identity)|human orfeome collection:8505(identity)|ddbj/embl/genbank:BC029041(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:A93wR7p6Gq/mhXo3vA1HjfVWmGs9606 intact-crc:D94EBA420BDA2D9D|rigid:FWbMk/iYZlAXO///1Pb758JMr+U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:A8K251 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9357406 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:a8k251_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357453|imex:IM-22301-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:A8K251(identity)|entrezgene/locuslink:26137(identity)|human orfeome collection:8505(identity)|ddbj/embl/genbank:BC029041(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:A93wR7p6Gq/mhXo3vA1HjfVWmGs9606 intact-crc:93747EB656D572DE|rigid:TYDHqDYmK3UTANVNEkNRc5n0FzY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K251 uniprotkb:Q6PK50 intact:EBI-9357406 intact:EBI-9356629 psi-mi:a8k251_human(display_long) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357431|imex:IM-22301-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:A8K251(identity)|entrezgene/locuslink:26137(identity)|human orfeome collection:8505(identity)|ddbj/embl/genbank:BC029041(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:A93wR7p6Gq/mhXo3vA1HjfVWmGs9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:B6A408EE8198FC01|rigid:ARR5+Fk6Q78SUW8rclVNR2ENyZI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K251 uniprotkb:Q9BTE6-2 intact:EBI-9357406 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:a8k251_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357497|imex:IM-22301-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:A8K251(identity)|entrezgene/locuslink:26137(identity)|human orfeome collection:8505(identity)|ddbj/embl/genbank:BC029041(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:A93wR7p6Gq/mhXo3vA1HjfVWmGs9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:C4E7B1D1037BF82D|rigid:P7I59i/ScEgf/5ErbsE0SAidoAo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K251 uniprotkb:Q96BE0 intact:EBI-9357406 intact:EBI-9356686 psi-mi:a8k251_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357475|imex:IM-22301-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:A8K251(identity)|entrezgene/locuslink:26137(identity)|human orfeome collection:8505(identity)|ddbj/embl/genbank:BC029041(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:A93wR7p6Gq/mhXo3vA1HjfVWmGs9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:D668E854FE5335DB|rigid:EnOEQqN/LoV9tMMdcfXCOsJIJGw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:A8K2M0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9357522 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357519|imex:IM-22301-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 intact-crc:6062FC421A9B5169|rigid:93e3EzPC7sbbMQLkOSOfpZVS87U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K2M0 uniprotkb:Q15773 intact:EBI-9357522 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357544|imex:IM-22301-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:B7344F73F7951AE1|rigid:EJSudQorobw7yY7QrlkrMk+ZR24 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:A8K2M0 intact:EBI-9356749 intact:EBI-9357522 psi-mi:q53fc7_human(display_long) psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357566|imex:IM-22301-40 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 intact-crc:F8ACF3EC07D2C395|rigid:ZPKf8ZHflro7bu3AdLoYUoBuRgk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K2M0 uniprotkb:Q16186 intact:EBI-9357522 intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2 psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357588|imex:IM-22301-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N|uniprotkb:Q16186(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606 intact-crc:D79156803322BBBA|rigid:3TXl1i/wJwTW628rdAprHez7W9c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K2M0 uniprotkb:Q13200 intact:EBI-9357522 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357607|imex:IM-22301-42 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:4C3341ACF41367A8|rigid:4P6wwM0ZfckWq25ttdvXcJO3qi8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K2M0 uniprotkb:Q9BTE6-2 intact:EBI-9357522 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357651|imex:IM-22301-44 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:8F03DAA964F5DE7C|rigid:0mgqERbg/QY2cWnKHk5/awGCNEk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B2RB89 uniprotkb:P07900 intact:EBI-9357676|uniprotkb:D3DT10 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:b2rb89_human(display_long)|uniprotkb:PRKACB(gene name)|psi-mi:PRKACB(display_short)|uniprotkb:hCG_23660(orf name) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357673|imex:IM-22301-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_002722.1|interpro:IPR044109|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:B2RB89(identity)|ddbj/embl/genbank:BC035058(identity)|entrezgene/locuslink:5567(identity)|human orfeome collection:2348(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FEzsjRJZlkFu5+KK4abzu7oAY9E9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:00A9A39DA0596F84|rigid:LJff9Gt5HHjhISryV3ouaG5JwZE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A8K2M0 uniprotkb:Q96BE0 intact:EBI-9357522 intact:EBI-9356686 psi-mi:a8k2m0_human(display_long)|uniprotkb:26S proteasome regulatory subunit 6B(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:hCG_43346(orf name)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357629|imex:IM-22301-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035256|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|refseq:NP_006494.1|interpro:IPR032501|interpro:IPR041569|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|uniprotkb:A8K2M0(identity)|entrezgene/locuslink:5704(identity)|human orfeome collection:4670(identity)|ddbj/embl/genbank:BC000343(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:B261E3DA4B7CE4EC|rigid:uJmq5Zm0puR27nYEycomV1MtBzE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B2RC52 uniprotkb:P58340 intact:EBI-9357718 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:b2rc52_human(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357721|imex:IM-22301-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|refseq:NP_000516.3|interpro:IPR040445|interpro:IPR041647|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|uniprotkb:B2RC52(identity)|human orfeome collection:56145(identity)|entrezgene/locuslink:3767(identity)|ddbj/embl/genbank:BC112358(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fEUbyHq+NZkCeuMZgT+oo3x1WyM9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:A42A648B1665C680|rigid:xNGZrCZ4LDrlQSWJPQ1bpfHrIAI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:B2RB89 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9357676|uniprotkb:D3DT10 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:b2rb89_human(display_long)|uniprotkb:PRKACB(gene name)|psi-mi:PRKACB(display_short)|uniprotkb:hCG_23660(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357698|imex:IM-22301-46 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_002722.1|interpro:IPR044109|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:B2RB89(identity)|ddbj/embl/genbank:BC035058(identity)|entrezgene/locuslink:5567(identity)|human orfeome collection:2348(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:FEzsjRJZlkFu5+KK4abzu7oAY9E9606 intact-crc:8497F2BB1C8A9995|rigid:hlbL0+G9Tupo9B9VPPSUEYhx/x8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:B2RC52 intact:EBI-9356686 intact:EBI-9357718 psi-mi:q96be0_human(display_long) psi-mi:b2rc52_human(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357765|imex:IM-22301-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|refseq:NP_000516.3|interpro:IPR040445|interpro:IPR041647|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|uniprotkb:B2RC52(identity)|human orfeome collection:56145(identity)|entrezgene/locuslink:3767(identity)|ddbj/embl/genbank:BC112358(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:fEUbyHq+NZkCeuMZgT+oo3x1WyM9606 intact-crc:DFCD5675009C81D9|rigid:KfQPX7AdFY3mAnep/xSB/ViteEs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B2RC52 uniprotkb:O95816 intact:EBI-9357718 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:b2rc52_human(display_long)|uniprotkb:"Inward rectifier K(+) channel Kir6.2"(gene name synonym)|uniprotkb:Potassium channel, inwardly rectifying subfamily J member 11(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357743|imex:IM-22301-48 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003279(Potassium channel, inwardly rectifying, Kir6.2)|interpro:IPR013518(Potassium channel, inwardly rectifying, Kir, cytoplasmic)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR016449(Potassium channel, inwardly rectifying, Kir)|refseq:NP_000516.3|interpro:IPR040445|interpro:IPR041647|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002931"(response to ischemia)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008282"(inward rectifying potassium channel)|go:"GO:0014704"(intercalated disc)|go:"GO:0015272"(ATP-activated inward rectifier potassium channel activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033198"(response to ATP)|go:"GO:0033574"(response to testosterone)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070852"(cell body fiber)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|uniprotkb:B2RC52(identity)|human orfeome collection:56145(identity)|entrezgene/locuslink:3767(identity)|ddbj/embl/genbank:BC112358(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:fEUbyHq+NZkCeuMZgT+oo3x1WyM9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:A03E3AC10476A284|rigid:E1xsr9Tmqpof+dmjnigqx4NN7R0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KM70 uniprotkb:B4DYC6 intact:EBI-9357787 intact:EBI-9357028 psi-mi:b3km70_human(display_long) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357812|imex:IM-22301-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|uniprotkb:B3KM70(identity)|entrezgene/locuslink:25827(identity)|ddbj/embl/genbank:BC031556(identity)|human orfeome collection:9208(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:ATGT65DIvDP3JBvMG5Rv74tjyic9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:60D75CECB2616E25|rigid:pJA4Men3ay8UAFcbOCUC5f9HLl8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KM70 uniprotkb:Q6PK50 intact:EBI-9357787 intact:EBI-9356629 psi-mi:b3km70_human(display_long) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357790|imex:IM-22301-50 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|uniprotkb:B3KM70(identity)|entrezgene/locuslink:25827(identity)|ddbj/embl/genbank:BC031556(identity)|human orfeome collection:9208(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATGT65DIvDP3JBvMG5Rv74tjyic9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:014781F64B31A472|rigid:MbcnblONwInI2OroL+XwU1jaL50 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:B3KQG4 intact:EBI-9356629 intact:EBI-9357857 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:b3kqg4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357854|imex:IM-22301-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_057597.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:B3KQG4(identity)|human orfeome collection:10179(identity)|ddbj/embl/genbank:BC035807(identity)|entrezgene/locuslink:22858(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:Q1JiU0fqZwcOv6elH7QnNApK51k9606 intact-crc:2B186C6BF109263A|rigid:G7n+3NScbD8i9q+nm7+fca/d5bU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KM70 uniprotkb:Q9BTE6-2 intact:EBI-9357787 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:b3km70_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357832|imex:IM-22301-52 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|uniprotkb:B3KM70(identity)|entrezgene/locuslink:25827(identity)|ddbj/embl/genbank:BC031556(identity)|human orfeome collection:9208(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATGT65DIvDP3JBvMG5Rv74tjyic9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:B33F42C9FA113D8F|rigid:/zQtMikTkKvWRIeeZpCK3wnJExU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KQG4 uniprotkb:Q16543 intact:EBI-9357857 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:b3kqg4_human(display_long) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357900|imex:IM-22301-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_057597.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:B3KQG4(identity)|human orfeome collection:10179(identity)|ddbj/embl/genbank:BC035807(identity)|entrezgene/locuslink:22858(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Q1JiU0fqZwcOv6elH7QnNApK51k9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:E0D67C8A649EDD89|rigid:cC9S4fuimft0FwLrrV1fPutdCBY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:B3KQG4 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-9357857 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:b3kqg4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357879|imex:IM-22301-54 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_057597.2|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:B3KQG4(identity)|human orfeome collection:10179(identity)|ddbj/embl/genbank:BC035807(identity)|entrezgene/locuslink:22858(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:Q1JiU0fqZwcOv6elH7QnNApK51k9606 intact-crc:FA786738B7AA0980|rigid:VENOHuvD85a78+54JsSmoNm3F70 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KTT5 uniprotkb:Q15773 intact:EBI-8783896 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:b3ktt5_human(display_long) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357920|imex:IM-22301-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:F2C00F7D43EFAD46|rigid:++7usZTrFkk55L73ylWSteXuejw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KTT5 uniprotkb:O95429 intact:EBI-8783896 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:b3ktt5_human(display_long) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357942|imex:IM-22301-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:D481F408EFB2185E|rigid:LwozVaQXUBwVDyZeCgf4ZrVhcsI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KTT5 uniprotkb:Q9HAV2 intact:EBI-8783896 intact:EBI-9357141 psi-mi:b3ktt5_human(display_long) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357964|imex:IM-22301-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:ADF76EE25778AB0B|rigid:OlLOUXNdNB7b0nwcb7m0TiBMMzk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:B3KV54 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9357989 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:b3kv54_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9357986|imex:IM-22301-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 intact-crc:7F9EAF1402899320|rigid:uue7XdiA6RLGq2V6mQ3Iw+eFgOI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KV54 uniprotkb:Q9HAV2 intact:EBI-9357989 intact:EBI-9357141 psi-mi:b3kv54_human(display_long) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358011|imex:IM-22301-60 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:81C2644BF12A70C4|rigid:0R348Bu60vkKYeLwhlSuIXUZKrw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KV54 uniprotkb:Q8IVD9 intact:EBI-9357989 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:b3kv54_human(display_long) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358033|imex:IM-22301-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:642C5B8BBE5EFEE7|rigid:o4Wj/FoygU49kfxckCB4L9InEiI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:B3KV54 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9357989 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:b3kv54_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358074|imex:IM-22301-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 intact-crc:FDA86E511C2D4695|rigid:hs1j9MmW6VJhAegWnO4gOTWHWMI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:B3KV54 intact:EBI-9356686 intact:EBI-9357989 psi-mi:q96be0_human(display_long) psi-mi:b3kv54_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358052|imex:IM-22301-62 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 intact-crc:4660693225F34D35|rigid:4B7ozE5m07n+XJbTzdKb7j0smXE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:B3KV54 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9357989 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:b3kv54_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358115|imex:IM-22301-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 intact-crc:E8A802F689DEB7D3|rigid:kNFxjVYJoZlWZz3xjnsmIQJyXok false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:B3KV54 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-9357989 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:b3kv54_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358096|imex:IM-22301-64 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_001309186.1|interpro:IPR044574|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR027417|refseq:NP_055921.2|interpro:IPR038718|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016787"(hydrolase activity)|go:"GO:0070615"|uniprotkb:B3KV54(identity)|human orfeome collection:12685(identity)|entrezgene/locuslink:23132(identity)|ddbj/embl/genbank:BC024298(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:3S1aF0pRhbk3LZEzI0RO0IGgoUg9606 intact-crc:C59740B13DECF364|rigid:1peDJOpiXE5SRi9eqTntCcVBjCM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:B4DE84 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9358161 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358164|imex:IM-22301-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:F951729D169A12CE|rigid:e2A/odwyXR8ritnm4ObNIdSnFOk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:B3KWD0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9358137 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:b3kwd0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358140|imex:IM-22301-66 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR011989(Armadillo-like helical)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_003391.1|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0015031"(protein transport)|uniprotkb:B3KWD0(identity)|entrezgene/locuslink:7514(identity)|human orfeome collection:1960(identity)|ddbj/embl/genbank:BC032847(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:i95ItAXn0EAltixiFI0mZfm/Aas9606 intact-crc:EC897B694C839389|rigid:QtyB6qkFm3QGnIX49Nfm2ZOLnjE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DE84 uniprotkb:Q6PK50 intact:EBI-9358161 intact:EBI-9356629 psi-mi:b4de84_human(display_long) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358205|imex:IM-22301-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:2C16BA03F619C5EF|rigid:ASPBXmECuJT1njPYdTYQlNsaAio false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:B4DE84 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9358161 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358183|imex:IM-22301-68 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:3B2F0C55151DDBB0|rigid:2tVzsQesGAsCenJlv48QiOE9JUQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DE84 uniprotkb:O43765 intact:EBI-9358161 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:b4de84_human(display_long) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358249|imex:IM-22301-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:C1A650EE2108F527|rigid:5u1W083wyyh8B7EvLN7wWizS6/c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:B4DE84 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9358161 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358227|imex:IM-22301-70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:669952EFA0F4566B|rigid:puaDKjcKjqMP6FyDMkzNEOoBtls false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:B4DE84 intact:EBI-9356686 intact:EBI-9358161 psi-mi:q96be0_human(display_long) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358271|imex:IM-22301-72 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:5AF0742C57A21172|rigid:y+Vxjz36oWyYM6kc+eanYdO6BaU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DE84 uniprotkb:Q9UNE7 intact:EBI-9358161 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:b4de84_human(display_long) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358293|imex:IM-22301-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:E8497122AA70DA58|rigid:mrqTg1hcf1EHqp7JckP580Upnro false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99614 uniprotkb:B4DE84 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-9358161 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358337|imex:IM-22301-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:754407C4DB48AB4C|rigid:VVye2NGP+Ks+12STp8LOwa2jq8E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:B4DE84 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9358161 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:b4de84_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358315|imex:IM-22301-74 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR009060(UBA-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|uniprotkb:B4DE84(identity)|entrezgene/locuslink:440248(identity)|ddbj/embl/genbank:BC047911(identity)|human orfeome collection:11657(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:qVWD5+rGMev4oFVnUSQy6UL2lVk9606 intact-crc:B73FE601C7B5EDEF|rigid:ercx8rjOS7iUoaN/BtFXhdxzncc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15185 uniprotkb:P07900 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358356|imex:IM-22301-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:4AE4838B0CA6E3E2|rigid:AyW8w3+FKTnKG2NhuhpWp3DUoxI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q15185 intact:EBI-9356629 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358375|imex:IM-22301-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:4FCDD6A748E3788A|rigid:fsIN4X/O/2EdqjrZjLGbahAgAC0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DR88 uniprotkb:Q96RS6 intact:EBI-9358395 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:b4dr88_human(display_long) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358398|imex:IM-22301-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_001159773.1|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:B4DR88(identity)|ddbj/embl/genbank:BC024187(identity)|human orfeome collection:1334(identity)|entrezgene/locuslink:79665(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:A+i0YXZ0zh6frlftPeHk6FZsBuM9606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:61E9AAC92E932A95|rigid:+yyqoC8x+vlp2XvZoa3qELmVZmQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q6PK50 intact:EBI-9357028 intact:EBI-9356629 psi-mi:b4dyc6_human(display_long) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358417|imex:IM-22301-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:E5370F9FB70B1208|rigid:OE9llSYx+A/0N9OKBbJJE43jGHw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00165 uniprotkb:P58340 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358437|imex:IM-22301-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165|uniprotkb:O00165(identity)|human orfeome collection:700(identity)|ddbj/embl/genbank:BC014314(identity)|entrezgene/locuslink:10456(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:7D1FF0DE63FA5719|rigid:48ViYziDbE0XUQ3iVvRelRvsGq0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O00165 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358459|imex:IM-22301-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165|uniprotkb:O00165(identity)|human orfeome collection:700(identity)|ddbj/embl/genbank:BC014314(identity)|entrezgene/locuslink:10456(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 intact-crc:977AAF086A5BB6B9|rigid:1j8A25tVS5AY1Tcak3vSBk/PYkY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:O00165 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358502|imex:IM-22301-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165|uniprotkb:O00165(identity)|human orfeome collection:700(identity)|ddbj/embl/genbank:BC014314(identity)|entrezgene/locuslink:10456(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 intact-crc:AE4AA5781643846C|rigid:bTOK4LD6XHkv//q+hvobM+6BbeQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00165 uniprotkb:Q15773 intact:EBI-357001|uniprotkb:A8W4W9|uniprotkb:A8W4X0|uniprotkb:B4DUJ7|uniprotkb:Q5VYD7|uniprotkb:Q5VYD5|uniprotkb:Q96AU4|uniprotkb:Q9BS80|ensembl:ENSP00000329002 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:hax1_human(display_long)|uniprotkb:HAX1(gene name)|psi-mi:HAX1(display_short)|uniprotkb:HS1BP1(gene name synonym)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358480|imex:IM-22301-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018238.1|refseq:NP_006109.2|dip:DIP-36771N|ensembl:ENSG00000143575(gene)|ensembl:ENST00000328703(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O00165|uniprotkb:O00165(identity)|human orfeome collection:700(identity)|ddbj/embl/genbank:BC014314(identity)|entrezgene/locuslink:10456(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:XRyEPYge2cQFiWdmOaiNIAxd1yQ9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:F5CB39BDE43E2B24|rigid:EDmcvSVlIqgJUChm7uQlMNd9kvI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14617 uniprotkb:Q13200 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358524|imex:IM-22301-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N|uniprotkb:O14617(identity)|entrezgene/locuslink:8943(identity)|human orfeome collection:6889(identity)|ddbj/embl/genbank:BC010065(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:37353115B11CDAF7|rigid:dhp2XbB9ZhnavWfXLRBowW8c8GQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14617 uniprotkb:P07900 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358546|imex:IM-22301-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N|uniprotkb:O14617(identity)|entrezgene/locuslink:8943(identity)|human orfeome collection:6889(identity)|ddbj/embl/genbank:BC010065(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:BD49543768F50A74|rigid:myFc1xFtEBL6FLiVeg1y19uTmdk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:Q15773 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358586|imex:IM-22301-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:7D63CDE886A43A3F|rigid:jY3L4fSvguKq0G1gGThQFnJf3oM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14617 uniprotkb:Q9HB71 intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358567|imex:IM-22301-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N|uniprotkb:O14617(identity)|entrezgene/locuslink:8943(identity)|human orfeome collection:6889(identity)|ddbj/embl/genbank:BC010065(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:E6AF91EC5222F37E|rigid:ROcSMTUV8TO1tzgmulQodiFskdw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:O43765 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358624|imex:IM-22301-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:B18FE52450E60183|rigid:ArOXthARayikzJ82XQGNnYj4Ik0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15185 uniprotkb:O14654 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358606|imex:IM-22301-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:46429DE497D46E99|rigid:lEpTcHiq4juBZQVJ0TukAhpWenM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:O14654 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358661|imex:IM-22301-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:263D2E4C5D7F5720|rigid:vcthrsFlwt1AnBSMGg7/KVLKwxI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:O14654 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358644|imex:IM-22301-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:A63538E21EAF936C|rigid:msN8onvOJJFUppbDB5jgAEB88ho false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:Q03933 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358681|imex:IM-22301-92 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:07260BD93CD73A7D|rigid:zePVasUqkCRq/AaeFBPKzSCUHC4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:Q8IVD9 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358698|imex:IM-22301-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:C13EF8C3019DD44C|rigid:XrEIWK7XLVftdb184dF7/CiHlrg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O14654 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358715|imex:IM-22301-94 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:CA93691AB8A33B00|rigid:e4299bFpmhQDR7jmeKEI5Ka1kcI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:Q96BE0 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-9356686 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358734|imex:IM-22301-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:F46ED909A138F85F|rigid:HPmKkRESokbyUUdRIRvDSG5pLJ4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:O14654 intact:EBI-9356778 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358754|imex:IM-22301-96 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:8A2C42E36E28E3EA|rigid:mAWVGfz2AYkVIvwaGp2DFwAotRI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14654 uniprotkb:Q9UIM3 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358794|imex:IM-22301-98 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:4408F9C2BC468647|rigid:X1tzANLGMGmaLYvLVOmM9lqwX50 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O14654 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358774|imex:IM-22301-97 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:EE60614A0358A197|rigid:oVWZMMi5A299MaMXbltp6lSTFE4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:O14775 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358811|imex:IM-22301-99 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:95EC8B08E1B9CBE0|rigid:+SSDRYmIIw4UYKbmHsltGhyyAvg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14775 uniprotkb:Q15773 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358833|imex:IM-22301-100 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:C35DFE3797B52F26|rigid:ZMNWNFsM2r3Dvn6FjeQGJ8huAzk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14775 uniprotkb:Q6PK50 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 intact:EBI-9356629 psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358855|imex:IM-22301-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:0DA537B6AFD87D77|rigid:SICcZNw63HQiUcerXOxzWqVc1KU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:O14775 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358899|imex:IM-22301-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:4EA2402DEC9DF149|rigid:M4+gFPX99oRVUEDFWHSkTTLTzBU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99615 uniprotkb:O14775 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358877|imex:IM-22301-102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:09B238905B481CCF|rigid:kxBJodnBOAz69Im3gJMn/z4hlsE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHV9 uniprotkb:O14775 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358918|imex:IM-22301-104 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:D05946B9E5EC8474|rigid:+szh9eyUpEOsoL/rokni4mRgel8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14775 uniprotkb:Q13200 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358938|imex:IM-22301-105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:B45ECA90AF482E0B|rigid:NaNnLyr9N6qR18MluWwJi49e5Pc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:O14775 intact:EBI-9356686 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:q96be0_human(display_long) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358960|imex:IM-22301-106 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:C48ECFE9F9BCECF5|rigid:f1xzo5pN+5rUpF4xXnEM4MgHy4A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:O14775 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9358982|imex:IM-22301-107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:6DD7B8860898AA58|rigid:Naoh4vhGgJk7j+VLlw3Z07HpHvw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:O14775 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359001|imex:IM-22301-108 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:3503AFB19FBD0E08|rigid:1i90n1Ux+LTFO11HXtKh0CtzlJU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14775 uniprotkb:Q3UJD6-2 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359020|imex:IM-22301-109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:9616E2DE7E68B9CF|rigid:7IoyYnEvG8iIZVLyt2KCqSO/9NU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O14775 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-713325|uniprotkb:Q9HAU9|uniprotkb:B2RBR5|uniprotkb:Q9UFT3|ensembl:ENSP00000261837 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:gnb5_human(display_long)|uniprotkb:Transducin beta chain 5(gene name synonym)|uniprotkb:Gbeta5(gene name synonym)|uniprotkb:GNB5(gene name)|psi-mi:GNB5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359046|imex:IM-22301-110 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_006569.1|refseq:NP_057278.2|ensembl:ENSG00000069966(gene)|ensembl:ENST00000261837(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0098793"(presynapse)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1902773"(GTPase activator complex)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|reactome:R-HSA-1296041|reactome:R-HSA-202040|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|uniprotkb:O14775(identity)|human orfeome collection:7017(identity)|ddbj/embl/genbank:BC013997(identity)|entrezgene/locuslink:10681(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:dP3wFmgi8uCvyTQAez6mWoULcd09606 intact-crc:AA8EF0BC82C70250|rigid:1N1WOiLm4EhkRwZKyJUCElqdnkA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14802 uniprotkb:Q6PK50 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 intact:EBI-9356629 psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359068|imex:IM-22301-111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|ddbj/embl/genbank:BC004928(identity)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:847E5BB1ACE8BD9D|rigid:+vF5Nb2lKpicsSRs7cItD3/qo4A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHV9 uniprotkb:O14802 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359090|imex:IM-22301-112 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 intact-crc:BB0A9D1627465F17|rigid:swm6LZr9NxP4DjCsUIDmq9eGaJg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:O14802 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359110|imex:IM-22301-113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 intact-crc:8BD5CBE687D6F57E|rigid:GYEVd4HpVXp44QD5bfaOIRXfnz8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:O14802 intact:EBI-9356686 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 psi-mi:q96be0_human(display_long) psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359129|imex:IM-22301-114 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 intact-crc:CB65302401F0B146|rigid:FVqWeUF6wU4r1wLoiLRfboJPEjU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14802 uniprotkb:Q15185 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359151|imex:IM-22301-115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:FB0069A071E64288|rigid:6QvkPVwyY3WxHSDGLaAg/cT4wUU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O14802 uniprotkb:Q9H6T3 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359171|imex:IM-22301-116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 intact-crc:F8259D69CED1AE5A|rigid:97DAArOLHOtrXRcg/xya7urDthM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:O14802 intact:EBI-9356778 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359193|imex:IM-22301-117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2|uniprotkb:O14802(identity)|entrezgene/locuslink:11128(identity)|ddbj/embl/genbank:BC041089(identity)|human orfeome collection:71125(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 intact-crc:8FAA36F75F0E186F|rigid:cDeBQ1Qkc37+Rufpj6wiFqYgIPQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15146 uniprotkb:Q13451 intact:EBI-6423196|uniprotkb:Q32MJ8|uniprotkb:Q5VZW8|uniprotkb:Q32MJ9|uniprotkb:Q5VZW7|ensembl:ENSP00000363571 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:musk_human(display_long)|uniprotkb:MUSK(gene name)|psi-mi:MUSK(display_short)|uniprotkb:Muscle-specific tyrosine-protein kinase receptor(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359215|imex:IM-22301-118 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159752.1|refseq:NP_001159753.1|refseq:NP_005583.1|ensembl:ENSG00000030304(gene)|ensembl:ENST00000374448(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020067|interpro:IPR020635|interpro:IPR036179|interpro:IPR036790|mint:O15146|reactome:R-HSA-3000178|uniprotkb:O15146(identity)|ddbj/embl/genbank:BC109098(identity)|human orfeome collection:53052(identity)|entrezgene/locuslink:4593(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+98T74K0J0OlFdo2neccLXgX8hA9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:08328397E0159E96|rigid:cehgI5v88T5Rson+5tHrTF7L4k4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15146 uniprotkb:Q6PK50 intact:EBI-6423196|uniprotkb:Q32MJ8|uniprotkb:Q5VZW8|uniprotkb:Q32MJ9|uniprotkb:Q5VZW7|ensembl:ENSP00000363571 intact:EBI-9356629 psi-mi:musk_human(display_long)|uniprotkb:MUSK(gene name)|psi-mi:MUSK(display_short)|uniprotkb:Muscle-specific tyrosine-protein kinase receptor(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359234|imex:IM-22301-119 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159752.1|refseq:NP_001159753.1|refseq:NP_005583.1|ensembl:ENSG00000030304(gene)|ensembl:ENST00000374448(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020067|interpro:IPR020635|interpro:IPR036179|interpro:IPR036790|mint:O15146|reactome:R-HSA-3000178|uniprotkb:O15146(identity)|ddbj/embl/genbank:BC109098(identity)|human orfeome collection:53052(identity)|entrezgene/locuslink:4593(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+98T74K0J0OlFdo2neccLXgX8hA9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:47D437466104A112|rigid:dcyTQo/913yENQJ5tG7OqqW6MvU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15146 uniprotkb:Q16543 intact:EBI-6423196|uniprotkb:Q32MJ8|uniprotkb:Q5VZW8|uniprotkb:Q32MJ9|uniprotkb:Q5VZW7|ensembl:ENSP00000363571 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:musk_human(display_long)|uniprotkb:MUSK(gene name)|psi-mi:MUSK(display_short)|uniprotkb:Muscle-specific tyrosine-protein kinase receptor(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359277|imex:IM-22301-121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159752.1|refseq:NP_001159753.1|refseq:NP_005583.1|ensembl:ENSG00000030304(gene)|ensembl:ENST00000374448(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020067|interpro:IPR020635|interpro:IPR036179|interpro:IPR036790|mint:O15146|reactome:R-HSA-3000178|uniprotkb:O15146(identity)|ddbj/embl/genbank:BC109098(identity)|human orfeome collection:53052(identity)|entrezgene/locuslink:4593(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+98T74K0J0OlFdo2neccLXgX8hA9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:4F083CB04A15C6FB|rigid:AugghkCSQJ94ilBcKld8WYBgC1s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15146 uniprotkb:P07900 intact:EBI-6423196|uniprotkb:Q32MJ8|uniprotkb:Q5VZW8|uniprotkb:Q32MJ9|uniprotkb:Q5VZW7|ensembl:ENSP00000363571 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:musk_human(display_long)|uniprotkb:MUSK(gene name)|psi-mi:MUSK(display_short)|uniprotkb:Muscle-specific tyrosine-protein kinase receptor(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359256|imex:IM-22301-120 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159752.1|refseq:NP_001159753.1|refseq:NP_005583.1|ensembl:ENSG00000030304(gene)|ensembl:ENST00000374448(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007613"(memory)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:2000541"(positive regulation of protein geranylgeranylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020067|interpro:IPR020635|interpro:IPR036179|interpro:IPR036790|mint:O15146|reactome:R-HSA-3000178|uniprotkb:O15146(identity)|ddbj/embl/genbank:BC109098(identity)|human orfeome collection:53052(identity)|entrezgene/locuslink:4593(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+98T74K0J0OlFdo2neccLXgX8hA9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:320E4B5C3903E77C|rigid:opP3FoUPHI+WyZLs10imlh/ILZA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:Q6PK50 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-9356629 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359297|imex:IM-22301-122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:B3D43477B309C69B|rigid:NUcyl/L2ytapG/jj8p/StkGkAWA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:O15519 intact:EBI-9356749 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 psi-mi:q53fc7_human(display_long) psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359319|imex:IM-22301-123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 intact-crc:4F3CBA1D32A21BFC|rigid:1UDHT16c42wtYRyWaNcwFt1YH2Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:O15519 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359341|imex:IM-22301-124 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 intact-crc:F3D3F57D0F5FDBDB|rigid:/S9xMEIrV6/AUXnBWpEnsJpyx9k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:B4DYC6 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-9357028 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359360|imex:IM-22301-125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:363DD43DC4224381|rigid:n9ZjKUkXAUxIcigp5+nHyxvlOZQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:Q13200 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359380|imex:IM-22301-126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:87D2FFD56617A48E|rigid:aCA/uXqpYMJpNtkRE4VN5FOtO2Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:Q9UIM3 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359424|imex:IM-22301-128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:8039201FE1B0D72A|rigid:qWTfGZhZ8p2I8lNGpq4wRTuY6vI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:Q96BE0 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-9356686 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359402|imex:IM-22301-127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:8FF3DDF32E95A869|rigid:LSafmEC1FHJSvyt9yNUJ+0yTv3o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15519 uniprotkb:Q9UNE7 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359443|imex:IM-22301-129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:706376D3D4B45092|rigid:kVBzKujI8S7aL6WuLepZyH9Ayps false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:O15519 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359465|imex:IM-22301-130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 intact-crc:605FC09890D864DF|rigid:s+9t86AAwjQmYY0edT52B02uXUY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O15519 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359484|imex:IM-22301-131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 intact-crc:9F0E435DE67471A1|rigid:aMgGXBloeUnT/pGClPrV3GuIDnc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:O15519 intact:EBI-9356778 intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359506|imex:IM-22301-132 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158|uniprotkb:O15519(identity)|ddbj/embl/genbank:BC001602(identity)|entrezgene/locuslink:8837(identity)|human orfeome collection:3742(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606 intact-crc:72309AE778DF0B1F|rigid:Wcl4pO2E3mRVac9itxIRSYoPw/o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:O15530-4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9087775|ensembl:ENSP00000268673 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:o15530-4(display_long)|uniprotkb:PDK1(gene name synonym)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359528|imex:IM-22301-133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) intact:EBI-717097(isoform-parent)|ensembl:ENSG00000140992(gene)|ensembl:ENST00000268673(transcript)|uniprotkb:O15530-4(isoform-parent)|uniprotkb:O15530-4(identity)|human orfeome collection:9307(identity)|entrezgene/locuslink:5170(identity)|ddbj/embl/genbank:BC006339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:xpGOPsJyFONnxfu4HaGOV4BLjX09606 intact-crc:C53F2508B980E68E|rigid:CGFpiaAKezu5qcaGyVj2Xfw7hBQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:O43151 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359570|imex:IM-22301-135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:E9A32D90A6D9D813|rigid:jqqDcORNDFRk6DfBn+ljzhrIUkk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:O15530-4 intact:EBI-9356686 intact:EBI-9087775|ensembl:ENSP00000268673 psi-mi:q96be0_human(display_long) psi-mi:o15530-4(display_long)|uniprotkb:PDK1(gene name synonym)|uniprotkb:PDPK1(gene name)|psi-mi:PDPK1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359548|imex:IM-22301-134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) intact:EBI-717097(isoform-parent)|ensembl:ENSG00000140992(gene)|ensembl:ENST00000268673(transcript)|uniprotkb:O15530-4(isoform-parent)|uniprotkb:O15530-4(identity)|human orfeome collection:9307(identity)|entrezgene/locuslink:5170(identity)|ddbj/embl/genbank:BC006339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:xpGOPsJyFONnxfu4HaGOV4BLjX09606 intact-crc:3E97E5E616F618E4|rigid:d/pr0WZrimHSeiCCXVgodi9akPk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:O43151 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359592|imex:IM-22301-136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:E9BFE49506BE994F|rigid:ezKR+TgiIYFlXs31iQgtmWYZXYA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:Q6PK50 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-9356629 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359614|imex:IM-22301-137 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:5067C55B59987EE7|rigid:6TJFmCcP4rg6vyfu5nJe1gH84xs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:O43151 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359636|imex:IM-22301-138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:3A260D768B4B4E0F|rigid:5UK6xgACFZHrMf0l1tvW60bpGgc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:O43151 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359655|imex:IM-22301-139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:C85B633BF823BCA5|rigid:O3FvFb9B5/gz2+Shxoel2n6BHqw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:O95816 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359677|imex:IM-22301-140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:CF950987FD0F45CB|rigid:RVhsRHSruxcJK3Wgj/+C1OMqxIw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:Q8IVD9 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359699|imex:IM-22301-141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:74692C1247F0006F|rigid:sPG0WwtyOf8w9WjnWZKLk9NwY1g false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:O43765 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359740|imex:IM-22301-143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:BC5725FABAE4D862|rigid:9K3OQiL6QMc6Gy1unNk2ySSx6aM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:Q13200 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359718|imex:IM-22301-142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:4E359F84F281FED2|rigid:DHbdN8ogUL+baoQdfI1ZSC+/0Qw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:Q96BE0 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-9356686 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359762|imex:IM-22301-144 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:6D09F43B2AC8E28F|rigid:vbSd4PlvVi8g1EBhx6WTtgc5JBc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:P31948 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359784|imex:IM-22301-145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:0EC762608660959F|rigid:49HcoovMyUQl6AGXo8KgVpzv1+c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:O43151 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359803|imex:IM-22301-146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:010126F94B352F2C|rigid:Sgzho0TRzthdVbR89h9iOc+RftU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:O43151 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359825|imex:IM-22301-147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:223A5DC8A87E3479|rigid:tHlvJSQqYB8wZTm933vCsWIyQDw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O43151 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359844|imex:IM-22301-148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 intact-crc:117AB8D0FFCAD8E9|rigid:djtbjubhC51jeBCAqMQFfjHeQCE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43151 uniprotkb:Q9BPW0 intact:EBI-2831148|uniprotkb:Q8TBM9|uniprotkb:A6NEI3|uniprotkb:Q86Z24|intact:EBI-28971009|ensembl:ENSP00000386869|uniprotkb:K9JJH7|uniprotkb:J3KNF3 intact:EBI-9356778 psi-mi:tet3_human(display_long)|uniprotkb:TET3(gene name)|psi-mi:TET3(display_short)|uniprotkb:KIAA0401(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359866|imex:IM-22301-149 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000386869|ensembl:ENST00000409262(transcript)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006211"(5-methylcytosine catabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0044727"(DNA demethylation of male pronucleus)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070579"(methylcytosine dioxygenase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0080111"(DNA demethylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR024779|interpro:IPR040175|rcsb pdb:4Z3C|reactome:R-HSA-5221030|ensembl:ENSG00000187605(gene)|refseq:XP_005264244.1|refseq:NP_001274420.1|uniprotkb:O43151(identity)|human orfeome collection:2581(identity)|entrezgene/locuslink:200424(identity)|ddbj/embl/genbank:BC022243(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/11/15 rogid:D1mz+jG5GQgTI29oOFE/fXkBSC49606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:A8762F06EC4F888C|rigid:ATXFavNwT9Nt3nSW7TkJwv1TtE8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:O43242 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359888|imex:IM-22301-150 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|uniprotkb:O43242(identity)|human orfeome collection:133(identity)|entrezgene/locuslink:5709(identity)|ddbj/embl/genbank:BC020518(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 intact-crc:0480F4B3B7C58F5C|rigid:L+9Ga60EIV7VDSJaAO6IcNyjrY4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43242 uniprotkb:Q15773 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359910|imex:IM-22301-151 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|uniprotkb:O43242(identity)|human orfeome collection:133(identity)|entrezgene/locuslink:5709(identity)|ddbj/embl/genbank:BC020518(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:B6D28FF8348A29E2|rigid:Auc42xcvKMZmzP9Q50cWMPNKdFk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43242 uniprotkb:Q13200 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359932|imex:IM-22301-152 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|uniprotkb:O43242(identity)|human orfeome collection:133(identity)|entrezgene/locuslink:5709(identity)|ddbj/embl/genbank:BC020518(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:1C7D95AEE660729B|rigid:CFuAl8LGCShWjQVyWi/H41l8I+A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43242 uniprotkb:Q9UIM3 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359954|imex:IM-22301-153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|uniprotkb:O43242(identity)|human orfeome collection:133(identity)|entrezgene/locuslink:5709(identity)|ddbj/embl/genbank:BC020518(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:EE94C3B2A9A71B95|rigid:naZtrkfRQ0i3qXHzHfYo0L+pMD0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43242 uniprotkb:Q9BTE6-2 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359973|imex:IM-22301-154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N|uniprotkb:O43242(identity)|human orfeome collection:133(identity)|entrezgene/locuslink:5709(identity)|ddbj/embl/genbank:BC020518(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:A6FB1344876B7593|rigid:tHaJ+sk87WrrovwCnoWyL9E7ej4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:O43293 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-77293|uniprotkb:A0AVN4|uniprotkb:B3KQE2|uniprotkb:Q05JY4|ensembl:ENSP00000301264|ensembl:ENSP00000442973 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:dapk3_human(display_long)|uniprotkb:DAPK3(gene name)|psi-mi:DAPK3(display_short)|uniprotkb:ZIPK(gene name synonym)|uniprotkb:DAP-like kinase(gene name synonym)|uniprotkb:Zipper-interacting protein kinase(gene name synonym)|uniprotkb:MYPT1 kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9359995|imex:IM-22301-155 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001339.1|refseq:XP_005259565.1|ensembl:ENSG00000167657(gene)|ensembl:ENST00000301264(transcript)|ensembl:ENST00000545797(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016605"(PML body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043519"(regulation of myosin II filament organization)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042870|mint:O43293|rcsb pdb:1YRP|rcsb pdb:2J90|rcsb pdb:3BHY|rcsb pdb:3BQR|rcsb pdb:5A6N|rcsb pdb:5A6O|rcsb pdb:5VJA|reactome:R-HSA-418889|uniprotkb:O43293(identity)|entrezgene/locuslink:1613(identity)|ddbj/embl/genbank:BC126430(identity)|human orfeome collection:54587(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:s8wsdvHltjaM7k0sJRNSjpXVpwM9606 intact-crc:909A1BBE8E56CF52|rigid:X0CUEPcwWU/UnZfWS4NPr3r+7Jo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:O43765 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360015|imex:IM-22301-156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:1A4724FF8C553DB9|rigid:+zzFPnNBCOsgySaDLA9XOSkEFPw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:O60502 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-715814|uniprotkb:O75166|uniprotkb:Q86WV0|uniprotkb:Q8IV98|uniprotkb:Q9BVA5|uniprotkb:Q9HAR0|uniprotkb:B7WPB9|uniprotkb:D3DR79|uniprotkb:E9PGF9|ensembl:ENSP00000354850 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:oga_human(display_long)|uniprotkb:OGA(gene name)|psi-mi:OGA(display_short)|uniprotkb:Beta-N-acetylglucosaminidase(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase(gene name synonym)|uniprotkb:Beta-hexosaminidase(gene name synonym)|uniprotkb:HEXC(gene name synonym)|uniprotkb:KIAA0679(gene name synonym)|uniprotkb:MEA5(gene name synonym)|uniprotkb:MGEA5(gene name synonym)|uniprotkb:Meningioma-expressed antigen 5(gene name synonym)|uniprotkb:N-acetyl-beta-D-glucosaminidase(gene name synonym)|uniprotkb:N-acetyl-beta-glucosaminidase(gene name synonym)|uniprotkb:Nuclear cytoplasmic O-GlcNAcase and acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360037|imex:IM-22301-157 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_001135906.1|refseq:NP_036347.1|ensembl:ENSG00000198408(gene)|ensembl:ENST00000361464(transcript)|go:"GO:0004415"(hyalurononglucosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0102166"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102167"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102571"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|interpro:IPR011496(Hyaluronidase eukaryotic/prokaryotic)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|rcsb pdb:2YDQ|rcsb pdb:5M7R|rcsb pdb:5M7S|rcsb pdb:5M7T|rcsb pdb:5M7U|rcsb pdb:5TKE|rcsb pdb:5UHK|rcsb pdb:5UHL|rcsb pdb:5UHO|rcsb pdb:5UHP|rcsb pdb:5UN8|rcsb pdb:5UN9|rcsb pdb:5VVO|rcsb pdb:5VVT|rcsb pdb:5VVU|rcsb pdb:5VVV|rcsb pdb:5VVX|rcsb pdb:6HKI|rcsb pdb:6PM9|go:"GO:0005634"(nucleus)|uniprotkb:O60502(identity)|entrezgene/locuslink:10724(identity)|ddbj/embl/genbank:BC039583(identity)|human orfeome collection:11311(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:KEvP6+2BWwsxrs8hsIjQhKAQGVo9606 intact-crc:3EE9336876E3AE36|rigid:IcOgq8flUrWS0PFt4r21JNlb4mg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:O60502 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-715814|uniprotkb:O75166|uniprotkb:Q86WV0|uniprotkb:Q8IV98|uniprotkb:Q9BVA5|uniprotkb:Q9HAR0|uniprotkb:B7WPB9|uniprotkb:D3DR79|uniprotkb:E9PGF9|ensembl:ENSP00000354850 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:oga_human(display_long)|uniprotkb:OGA(gene name)|psi-mi:OGA(display_short)|uniprotkb:Beta-N-acetylglucosaminidase(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase(gene name synonym)|uniprotkb:Beta-hexosaminidase(gene name synonym)|uniprotkb:HEXC(gene name synonym)|uniprotkb:KIAA0679(gene name synonym)|uniprotkb:MEA5(gene name synonym)|uniprotkb:MGEA5(gene name synonym)|uniprotkb:Meningioma-expressed antigen 5(gene name synonym)|uniprotkb:N-acetyl-beta-D-glucosaminidase(gene name synonym)|uniprotkb:N-acetyl-beta-glucosaminidase(gene name synonym)|uniprotkb:Nuclear cytoplasmic O-GlcNAcase and acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360056|imex:IM-22301-158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001135906.1|refseq:NP_036347.1|ensembl:ENSG00000198408(gene)|ensembl:ENST00000361464(transcript)|go:"GO:0004415"(hyalurononglucosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0102166"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102167"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102571"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|interpro:IPR011496(Hyaluronidase eukaryotic/prokaryotic)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|rcsb pdb:2YDQ|rcsb pdb:5M7R|rcsb pdb:5M7S|rcsb pdb:5M7T|rcsb pdb:5M7U|rcsb pdb:5TKE|rcsb pdb:5UHK|rcsb pdb:5UHL|rcsb pdb:5UHO|rcsb pdb:5UHP|rcsb pdb:5UN8|rcsb pdb:5UN9|rcsb pdb:5VVO|rcsb pdb:5VVT|rcsb pdb:5VVU|rcsb pdb:5VVV|rcsb pdb:5VVX|rcsb pdb:6HKI|rcsb pdb:6PM9|go:"GO:0005634"(nucleus)|uniprotkb:O60502(identity)|entrezgene/locuslink:10724(identity)|ddbj/embl/genbank:BC039583(identity)|human orfeome collection:11311(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:KEvP6+2BWwsxrs8hsIjQhKAQGVo9606 intact-crc:27CC7DBD98358B78|rigid:iWj2QdSzSAjknAd39VeLh72RRuo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:O60502 intact:EBI-9356686 intact:EBI-715814|uniprotkb:O75166|uniprotkb:Q86WV0|uniprotkb:Q8IV98|uniprotkb:Q9BVA5|uniprotkb:Q9HAR0|uniprotkb:B7WPB9|uniprotkb:D3DR79|uniprotkb:E9PGF9|ensembl:ENSP00000354850 psi-mi:q96be0_human(display_long) psi-mi:oga_human(display_long)|uniprotkb:OGA(gene name)|psi-mi:OGA(display_short)|uniprotkb:Beta-N-acetylglucosaminidase(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase(gene name synonym)|uniprotkb:Beta-hexosaminidase(gene name synonym)|uniprotkb:HEXC(gene name synonym)|uniprotkb:KIAA0679(gene name synonym)|uniprotkb:MEA5(gene name synonym)|uniprotkb:MGEA5(gene name synonym)|uniprotkb:Meningioma-expressed antigen 5(gene name synonym)|uniprotkb:N-acetyl-beta-D-glucosaminidase(gene name synonym)|uniprotkb:N-acetyl-beta-glucosaminidase(gene name synonym)|uniprotkb:Nuclear cytoplasmic O-GlcNAcase and acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360075|imex:IM-22301-159 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001135906.1|refseq:NP_036347.1|ensembl:ENSG00000198408(gene)|ensembl:ENST00000361464(transcript)|go:"GO:0004415"(hyalurononglucosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0102166"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102167"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102571"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|interpro:IPR011496(Hyaluronidase eukaryotic/prokaryotic)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|rcsb pdb:2YDQ|rcsb pdb:5M7R|rcsb pdb:5M7S|rcsb pdb:5M7T|rcsb pdb:5M7U|rcsb pdb:5TKE|rcsb pdb:5UHK|rcsb pdb:5UHL|rcsb pdb:5UHO|rcsb pdb:5UHP|rcsb pdb:5UN8|rcsb pdb:5UN9|rcsb pdb:5VVO|rcsb pdb:5VVT|rcsb pdb:5VVU|rcsb pdb:5VVV|rcsb pdb:5VVX|rcsb pdb:6HKI|rcsb pdb:6PM9|go:"GO:0005634"(nucleus)|uniprotkb:O60502(identity)|entrezgene/locuslink:10724(identity)|ddbj/embl/genbank:BC039583(identity)|human orfeome collection:11311(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:KEvP6+2BWwsxrs8hsIjQhKAQGVo9606 intact-crc:8C7E3E58843E1633|rigid:vesdb/Pi5jrG5wq7f3SbV8/o4kA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60884 uniprotkb:Q8WW22 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360097|imex:IM-22301-160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|ddbj/embl/genbank:BC013044(identity)|human orfeome collection:306(identity) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 intact-crc:42E75F19BBE49017|rigid:lBT8lIcoi+qVcUgN0jMTdGRO/Lo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60884 uniprotkb:Q9Y266 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360119|imex:IM-22301-161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|ddbj/embl/genbank:BC013044(identity)|human orfeome collection:306(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:1FF40035C74E6454|rigid:9Oq+mDn5IFX07m8cW+bZCIK8VVE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75132 uniprotkb:P58340 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360138|imex:IM-22301-162 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:60086EC096724CDE|rigid:yqAIk4Ire6n4DzOu07s99zlPyjQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O75132 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360160|imex:IM-22301-163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 intact-crc:9DE66F64CA38E63E|rigid:gUWxKzGwXA2i0UW4VEIt7GXfEyA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75132 uniprotkb:Q6PK50 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 intact:EBI-9356629 psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360181|imex:IM-22301-164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:482BCB6A33B189FF|rigid:bGwwncF7kHs+ILRpzG4tPkNZeBM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75132 uniprotkb:Q8IVD9 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360203|imex:IM-22301-165 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:403C9C0143525BB4|rigid:jvfU/pCOLvVBEc6Z94v3C/TJ4Ig false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O75132 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360243|imex:IM-22301-167 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 intact-crc:FB8F8A37A4629A9E|rigid:OOO87gSH1T5UJ3ZzefHWoPF9vxU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75132 uniprotkb:P07900 intact:EBI-2860059|uniprotkb:B2RZH1|uniprotkb:Q9UGG8|uniprotkb:Q1ECU0|ensembl:ENSP00000216268 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:zbed4_human(display_long)|uniprotkb:ZBED4(gene name)|psi-mi:ZBED4(display_short)|uniprotkb:KIAA0637(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360222|imex:IM-22301-166 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055653.2|ensembl:ENSG00000100426(gene)|ensembl:ENST00000216268(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR003656(Zinc finger, BED-type predicted)|interpro:IPR008906(HAT dimerisation)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036236|mint:O75132|uniprotkb:O75132(identity)|ddbj/embl/genbank:BC117670(identity)|human orfeome collection:56238(identity)|entrezgene/locuslink:9889(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T1pqiOcpLeOA25QudngK1xk+xaA9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:8E9FF43EDA3A2E81|rigid:ryS3/zcWPshhfIYk/aMdP7D+dso false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:O75159 intact:EBI-9356778 intact:EBI-970130|ensembl:ENSP00000305133|ensembl:ENSP00000378330|uniprotkb:Q8IYZ4|uniprotkb:Q53SD4 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:socs5_human(display_long)|uniprotkb:SOCS5(gene name)|psi-mi:SOCS5(display_short)|uniprotkb:CIS6(gene name synonym)|uniprotkb:CISH5(gene name synonym)|uniprotkb:CISH6(gene name synonym)|uniprotkb:KIAA0671(gene name synonym)|uniprotkb:Cytokine-inducible SH2-containing protein 5(gene name synonym)|uniprotkb:Cytokine-inducible SH2 protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360265|imex:IM-22301-168 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|go:"GO:0097699"(vascular endothelial cell response to fluid shear stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR022252|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR028420|interpro:IPR036036|interpro:IPR036860|interpro:IPR037343|mint:O75159|reactome:R-HSA-6785807|reactome:R-HSA-8951664|ensembl:ENSG00000171150(gene)|ensembl:ENST00000306503(transcript)|ensembl:ENST00000394861(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|refseq:NP_054730.1|refseq:NP_659198.1|uniprotkb:O75159(identity)|human orfeome collection:1990(identity)|entrezgene/locuslink:9655(identity)|ddbj/embl/genbank:BC032862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:U2knqF85DLJAaAivguVFoun87u89606 intact-crc:389527677EB26F86|rigid:3l581ZJWaxfWwEKHW2DD8szL1vs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:O75190 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360287|imex:IM-22301-169 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|human orfeome collection:8024(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:2A190EE3CE400B5A|rigid:JT/SLkSfPjcmjYzpskTnK6lXDqU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O75190 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360309|imex:IM-22301-170 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|human orfeome collection:8024(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:DE1CE49550CEE5EA|rigid:kRiBR8sAps37UB3C8Dmugye/u/0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:O75190 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360330|imex:IM-22301-171 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|human orfeome collection:8024(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:1DDFA5E4F4D23762|rigid:E8NyzVIbIHY7w4rq8WCmzGdxzPs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75190 uniprotkb:Q13200 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360352|imex:IM-22301-172 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|human orfeome collection:8024(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:4E9D2C5671405C62|rigid:4ph6ob+azXW72HKm/DnSunOEFrg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O75190 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360374|imex:IM-22301-173 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|human orfeome collection:8024(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:2C59E05D1BB82B25|rigid:Q/6lwn4iys9GTIFC2eiDWGdD1i4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-2 uniprotkb:O75344 intact:EBI-9359023|ensembl:ENSMUSP00000082119 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360396|imex:IM-22301-174 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 intact-crc:5B2A069B7B0D34F8|rigid:suGOGovKW1wM1JJTwSVoNYs8NiU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q8K2C9 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360417|imex:IM-22301-175 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 intact-crc:2329CF8FC54F5C75|rigid:oY2WJwXti4h6f/jOj7Pe4nBNCE0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q6PK50 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-9356629 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360438|imex:IM-22301-176 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:BD2BCA2A36B18BA3|rigid:smPL1wticYL/G2io90tNlHl8AkA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q53FC7 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-9356749 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360460|imex:IM-22301-177 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:298776B157069433|rigid:YVptn8vTmwpAzGhqMKo55By+iWo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q03933 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360482|imex:IM-22301-178 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:E1B36256E7E05D13|rigid:0NsccyrSU+dDe1OSchSCrhWnDqY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q8IVD9 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360520|imex:IM-22301-180 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:D2A1ADF985BDC5E3|rigid:AKQBF7m8rpeJ+khmqeEgAoxoMM0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9Y266 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360501|imex:IM-22301-179 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:AEDB8E51DD1CE12B|rigid:woIkaHEv5KsGp9+atj92xqqyWGs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:P07900 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360539|imex:IM-22301-181 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:575DAF6BBBF72A3E|rigid:Q7HIuZK09ivIT6I3A2Xaa9lpzak false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9UIM3 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360560|imex:IM-22301-182 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:0E5F257EF6C2809B|rigid:wZi1lLz1R95RikcVv5W99x+JDNk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9UNE7 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360579|imex:IM-22301-183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:0509930F262175F6|rigid:I5z3zAhxa8zJ1oBjpWGNHDJdN0s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9HB71 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360601|imex:IM-22301-184 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:2911C29D3F9CB378|rigid:LyUOeBZFt/zynb4eKO+rRjZfDC4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q8WVJ2 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360620|imex:IM-22301-185 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:185B67F56073C2AD|rigid:WfM+lbRtM27d5+kNxdtBjj/WQqg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q15185 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360639|imex:IM-22301-186 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:4AD5D20E50E439E7|rigid:hk1AXA+Z3aVPs08Lw7cuhfWLzc0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9BTE6-2 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360659|imex:IM-22301-187 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:4A7524916DCEB73E|rigid:y2iFqnJ4ZHv6brzuK8DFcxJo924 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:Q9BPW0 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-9356778 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360681|imex:IM-22301-188 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|ddbj/embl/genbank:BC067293(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|ddbj/embl/genbank:BC001970(identity)|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:7CBAB85300BD5654|rigid:0gKMoguRuXi+Q80XlzKA3X7EGRM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q03933 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360703|imex:IM-22301-189 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:C93B9DA7B485B804|rigid:/vq7eNJxUw7cL3RjSBEpICV4iTI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q9UHV9 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360722|imex:IM-22301-190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:F292A5B747E8D2F5|rigid:kjV9mdmEE5+4pn0+uf4Vg4A1qEI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:O94763 intact:EBI-9357141 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:q9hav2_human(display_long) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360742|imex:IM-22301-191 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:24746E5148548EDF|rigid:d2vhkg0wch2KZsGdZkxKPkwXlmw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q8IVD9 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360764|imex:IM-22301-192 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:5383E6C112DC6262|rigid:Uv47AONVj8YvDlAn+bv4MNF4teM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:O94763 intact:EBI-9357028 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:b4dyc6_human(display_long) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360783|imex:IM-22301-193 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:1B120CBCCD1C0064|rigid:qL+CQu3I1D7p6Zxk1HS83lWy1Bc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q13200 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360803|imex:IM-22301-194 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:521F71FF18A5F398|rigid:bIq6ekqLmcDEYqCKXLEfm49Pxcc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:P31948 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360825|imex:IM-22301-195 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:97769692D6E200BB|rigid:jgx5a7mSLWvuyzMAJvPTjm9/77Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:O94763 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360844|imex:IM-22301-196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:05356816FBC792C1|rigid:VzIpkLj8eWplir7HntnIsmrC3U4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75344 uniprotkb:O94763 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360864|imex:IM-22301-197 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:484300311B65945E|rigid:bK0LBg9nPumfPJBkhLnzeipju6E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q9HB71 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360886|imex:IM-22301-198 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:4AD086D7FCA493D7|rigid:kaqmqdvLsk921VdF0uey2MsHOMg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:O00170 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360905|imex:IM-22301-199 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:3104B9EB880F9F35|rigid:7CNbWAlyCiXCad4eqUfxHoAp/BE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:O94763 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360924|imex:IM-22301-200 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:B12DCE21D6A90A1B|rigid:M1BJf+iDwcStXKLuwSqd1407bR8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94763 uniprotkb:Q15185 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360943|imex:IM-22301-201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:0827E511BDA0AE7E|rigid:dQPCO9sg93hQVJZbVRBvI+3RMfo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94906 uniprotkb:Q15773 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360985|imex:IM-22301-203 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N|uniprotkb:O94906(identity)|ddbj/embl/genbank:BC001666(identity)|entrezgene/locuslink:24148(identity)|human orfeome collection:6726(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:63968842D27FE799|rigid:rVEck0FIK6I9Sey/VslR7ABq7xk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:O94763 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9360963|imex:IM-22301-202 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|human orfeome collection:71259(identity)|ddbj/embl/genbank:BC067259(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:14EE35C474CDF7AE|rigid:cigebYp9Vw3YGQjsK6Y/llpiEpE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:O94906 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361007|imex:IM-22301-204 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N|uniprotkb:O94906(identity)|ddbj/embl/genbank:BC001666(identity)|entrezgene/locuslink:24148(identity)|human orfeome collection:6726(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 intact-crc:58482F5301456D03|rigid:aOXyzIzg7fJowE15leCkIvgGBFE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94906 uniprotkb:Q9BTE6-2 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361029|imex:IM-22301-205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N|uniprotkb:O94906(identity)|ddbj/embl/genbank:BC001666(identity)|entrezgene/locuslink:24148(identity)|human orfeome collection:6726(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:26D7E683B2FE1C5C|rigid:vFuXN0pNymiNRhe7dIZ8sTD9B9c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:O94966-1 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9361054|ensembl:ENSP00000381863 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361051|imex:IM-22301-206 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:6DE8D3CD53081CB0|rigid:Q2yQHFnpvBT8GWU6FynqtLvIZtE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L3B6 uniprotkb:O94966-1 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-9361054|ensembl:ENSP00000381863 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361078|imex:IM-22301-207 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:C6ADA43622B35865|rigid:y4JxCpoXdEzn8ulDlAXw9RmITOs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94966-1 uniprotkb:Q13200 intact:EBI-9361054|ensembl:ENSP00000381863 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361100|imex:IM-22301-208 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:55547DD04877E3A5|rigid:aDv8Lsam4c3JCtwgCRUnbHDODOg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94966-1 uniprotkb:Q8IVD9 intact:EBI-9361054|ensembl:ENSP00000381863 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361122|imex:IM-22301-209 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:B27D6EF39CAFC64A|rigid:hQj7ZUVoahVkY57QuyasLlVmL8k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O94966-1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9361054|ensembl:ENSP00000381863 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361141|imex:IM-22301-210 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:47D4F7C1FADB9D08|rigid:yo9fXzBmtGqgizdOe/BURh7SNuE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94966-1 uniprotkb:Q6PK50 intact:EBI-9361054|ensembl:ENSP00000381863 intact:EBI-9356629 psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361162|imex:IM-22301-211 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:6A991628813BF85C|rigid:xnbIcOoHmAZT0vtmpg/nnA+86Lg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O94966-1 uniprotkb:O43765 intact:EBI-9361054|ensembl:ENSP00000381863 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:o94966-1(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361184|imex:IM-22301-212 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|intact:EBI-2511895(isoform-parent)|uniprotkb:O94966-1(identity)|ddbj/embl/genbank:BC146752(identity)|human orfeome collection:72157(identity)|entrezgene/locuslink:10869(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:67DFABBED91688E0|rigid:W9nTG5NJGI+82Lx/dL4XWKT7+2Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:P58340 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361217|imex:IM-22301-213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:311FC2C3F74D5942|rigid:9XABIJvwROd362df7LEzp2BAblo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:O95072 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361239|imex:IM-22301-214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 intact-crc:23B70D7A636248BC|rigid:fQe4XI3wE+RcRvk0FRefqAIgxbA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:O95072 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361260|imex:IM-22301-215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 intact-crc:2AFCC1F7138FA346|rigid:69Cm2gP06N2C9bf7f/l+Cv3Lwjk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:O95072 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361282|imex:IM-22301-216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 intact-crc:A83DEDA127D528A8|rigid:/uu6DtfEIbnZD92LYhYNytm2wzA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:Q13200 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361304|imex:IM-22301-217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:8F13749B69A4D13C|rigid:W2y7XtNf4XcbyEL3sZy7WzBh+6w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:O43765 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361326|imex:IM-22301-218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:D6414F4897CD18E2|rigid:DnZTitC6rK+rWSJ9w/TBVroOKxo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:Q96BE0 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-9356686 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361348|imex:IM-22301-219 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:8DCC17846EF057C6|rigid:akkf5jXNDLgzm8TXaT5GvXA+MSY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:P31948 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361370|imex:IM-22301-220 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:FF33731F43AD8162|rigid:4lffHvMcudJKaSX/XiLCSpMd4Ss false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:Q9UNE7 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361389|imex:IM-22301-221 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:F1D93B10F4529575|rigid:arMGUaogasXJPzugGEaKw1DfIqA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:O95072 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361411|imex:IM-22301-222 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 intact-crc:B1BFEDCF1DEEF60F|rigid:wtlY1qzRHNjM01y01LpAYvx+Ozo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95072 uniprotkb:Q9BTE6-2 intact:EBI-9361206|uniprotkb:Q658V5|uniprotkb:Q6IA92|uniprotkb:D3DS62|uniprotkb:Q8WUV8|uniprotkb:A8K576|uniprotkb:Q9NVQ9|uniprotkb:Q9BTF2|ensembl:ENSP00000482439|ensembl:ENSP00000482546|ensembl:ENSP00000493523|ensembl:ENSP00000495458 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:rec8_human(display_long)|uniprotkb:REC8(gene name)|psi-mi:REC8(display_short)|uniprotkb:Cohesin Rec8p(gene name synonym)|uniprotkb:REC8L1(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361430|imex:IM-22301-223 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041670.1|refseq:NP_005123.2|ensembl:ENSG00000100918(gene)|ensembl:ENSG00000285007(gene)|ensembl:ENST00000611366(transcript)|ensembl:ENST00000620473(transcript)|ensembl:ENST00000642486(transcript)|ensembl:ENST00000646765(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0034990"(nuclear mitotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|interpro:IPR006909(Rad21/Rec8 like protein, C-terminal)|interpro:IPR006910(Rad21/Rec8 like protein, N-terminal)|interpro:IPR023093|interpro:IPR036390|interpro:IPR039781|mint:O95072|reactome:R-HSA-1221632|uniprotkb:O95072(identity)|entrezgene/locuslink:9985(identity)|human orfeome collection:5371(identity)|ddbj/embl/genbank:BC004159(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DQKOCe+CcQ6mDGL+8bpeW0PGbe49606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:2980D763B6580923|rigid:2k++Qm8fi27rbfcXYgBIuEzXB0A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:Q53FC7 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-9356749 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361452|imex:IM-22301-224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:78CAFD4A587AD261|rigid:rqsonoZb6v55W3vRWlnyP0jQniY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:Q03933 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361474|imex:IM-22301-225 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:2A39445810B2FF5B|rigid:lDlyp3Aaj2old2TrFhoktIqbzG8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:P58340 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361493|imex:IM-22301-226 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:B34FF389FD3302A4|rigid:9LjjdN6scG9nOpmucFOxwS07xUM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:O95816 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361515|imex:IM-22301-227 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:AE19229AA2876631|rigid:RXuDqsLXcC8mt/2B/10zav4ed88 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:O95816 intact:EBI-9356749 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q53fc7_human(display_long) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361537|imex:IM-22301-228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:D22C62617AF2F373|rigid:XIaGnVUSCCsz1gF/yit6YlZpCeM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q03933 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361559|imex:IM-22301-229 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:786E4D43689E9BA8|rigid:rv8O0gI85FK6JVf50xt3L0xhr4w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:O95816 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361578|imex:IM-22301-230 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:17CDA5F8CF07285D|rigid:joCifyeLtuoRHaBPJ4+E50y0cJg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:O95816 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361597|imex:IM-22301-231 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:45B68C8879A46C0E|rigid:D+PYNNjkskmFNwUoflTcGaR4Luc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q9HAV2 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9357141 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361619|imex:IM-22301-232 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:B582B0F3F00E5BA4|rigid:zHBz153+PxaTFGJs3R91UAjCIQQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q8IVD9 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361641|imex:IM-22301-233 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:90CA9D6F030436EA|rigid:eBomesZ0887PWlJHF/CfYG7DfTs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q13200 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361660|imex:IM-22301-234 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|entrezgene/locuslink:5708(identity)|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:531EB2FAF796E5C9|rigid:vNDxMLR7vd6mBXk+PcpxTWukj70 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:O95816 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361682|imex:IM-22301-235 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:ACAF90AE51E58870|rigid:+mSmxG4hPM/mK+Blr77M/TA9Fek false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q719I0 uniprotkb:O95816 intact:EBI-9361704|uniprotkb:Q8NDU5|uniprotkb:D6W5E0|uniprotkb:B3KS51 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:ahsa2_human(display_long)|uniprotkb:AHSA2P(gene name)|psi-mi:AHSA2P(display_short)|uniprotkb:AHSA2(gene name synonym)|uniprotkb:Activator of HSP90 ATPase homolog 2 pseudogene(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361711|imex:IM-22301-236 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR023393|refseq:NP_001308229.1|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|refseq:NP_689605.1|interpro:IPR036338|interpro:IPR039981|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:Q719I0(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:cKfjoKsqFsak3gNl4dGt8OXDhtg9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:EDE38E645FFD8A19|rigid:FO4+Dx1Bl4ZDQOu8EGxH8dSfPBg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:O95816 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361735|imex:IM-22301-237 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:B0BA509F9B0F1AF4|rigid:NMjvHuuyuqyt4XxqiQD0GhLr0EE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q96BE0 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9356686 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361756|imex:IM-22301-238 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:2C9C265978EC8698|rigid:L0TWEil50diNVSC3UEdTSyXQFQE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q9UIM3 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361778|imex:IM-22301-239 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:7A3681A0A6F6F63A|rigid:+HdE3GCImEBKjIgiASY51Uuy/wk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:O95816 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361797|imex:IM-22301-240 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:2F32F91E453C82BF|rigid:7cLd0nPZwmzRI3CBqgpBfb4W2So false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q9HB71 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361819|imex:IM-22301-241 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:801A4771ED3236B0|rigid:XKhT4QERePLGCczTZD2bbZfBXfI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q3UJD6-2 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361838|imex:IM-22301-242 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:8CEE581490F04797|rigid:kxM00ZcS/DcXu2tvlomfFucsEsw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q9BTE6-2 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361859|imex:IM-22301-243 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:5A49D5993DF97022|rigid:f59iDwwSTjkjeOka0RaKiMqre0I false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:P58340 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361881|imex:IM-22301-244 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:E596EDBD8A69CBC6|rigid:42Fhx0e45AVgau99YJE7F8K+tCg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:O95817 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361903|imex:IM-22301-245 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:825870E994F11283|rigid:8VjIjBgQQ0PXKsS31CigL/jAdVU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q53FC7 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-9356749 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361925|imex:IM-22301-246 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:719D2F416A869A0F|rigid:5+tUBdEIgl3q+KegIjeUVcJtHDw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:O95817 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361947|imex:IM-22301-247 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:08ABEA2701272299|rigid:1CLHXALlCaTb7oi+XxpFTIHvrdk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:O95817 intact:EBI-9357141 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:q9hav2_human(display_long) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361966|imex:IM-22301-248 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:197536B01A9CBB57|rigid:FDLqjxaW7cerED0bwJ6ojElNCp4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04792 uniprotkb:O95817 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9361988|imex:IM-22301-249 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|entrezgene/locuslink:3315(identity)|ddbj/embl/genbank:BC012292(identity)|human orfeome collection:618(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) crc64:1B4DC44A6F6606D5 - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:096E4B7A9A4CB227|rigid:nJPG+IuF1857EgjbayFDDdEgghY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q13200 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362010|imex:IM-22301-250 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:7E3915620129D614|rigid:vgxOFgKB23ARkF44xsN4ne55tWQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q3UJD6-1 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362032|imex:IM-22301-251 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:40316BA8C34BA2B9|rigid:O7cum8DDaTLCNPccWPio/gefiMw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q96BE0 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-9356686 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362053|imex:IM-22301-252 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:E5938C7FA3DE3D60|rigid:F0Zd5ccYBZpGN2izxkQDNlEo3lY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q9UNE7 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362075|imex:IM-22301-253 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:5BD7EBBD1C8253F1|rigid:pVyPliB/OHcMmBMbg46aGPPF/UY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B3KTT5 uniprotkb:O95817 intact:EBI-8783896 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:b3ktt5_human(display_long) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362097|imex:IM-22301-254 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:D780D0342C44CB23|rigid:guAMJyvasb2uxqDHd2cmfbPXsYw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95985 uniprotkb:Q9BTE6-2 intact:EBI-373403|uniprotkb:A0M8Q3|uniprotkb:Q9BUP5|ensembl:ENSP00000349705|ensembl:ENSP00000381773 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:top3b_human(display_long)|uniprotkb:TOP3B(gene name)|psi-mi:TOP3B(display_short)|uniprotkb:TOP3B1(gene name synonym)|uniprotkb:DNA topoisomerase III beta-1(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362119|imex:IM-22301-255 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003926.1|refseq:XP_011528784.1|refseq:XP_006724412.1|refseq:XP_006724413.1|refseq:NP_001269041.1|refseq:NP_001269042.1|refseq:XP_005261868.1|ensembl:ENSG00000100038(gene)|ensembl:ENST00000357179(transcript)|ensembl:ENST00000398793(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003917"("DNA topoisomerase type I (single strand cut, ATP-independent) activity")|go:"GO:0005634"(nucleus)|go:"GO:0006265"(DNA topological change)|go:"GO:0007059"(chromosome segregation)|interpro:IPR000380(DNA topoisomerase, type IA, core)|interpro:IPR003601(DNA topoisomerase, type IA, domain 2)|interpro:IPR003602(DNA topoisomerase, type IA, DNA-binding)|interpro:IPR006171(TOPRIM)|interpro:IPR013825(DNA topoisomerase, type IA, central region, subdomain 2)|interpro:IPR013826(DNA topoisomerase, type IA, central region, subdomain 3)|interpro:IPR023405|interpro:IPR023406|interpro:IPR034144|mint:O95985|rcsb pdb:5GVC|rcsb pdb:5GVE|interpro:IPR013497(DNA topoisomerase, type IA, central)|interpro:IPR013824(DNA topoisomerase, type IA, central region, subdomain 1)|uniprotkb:O95985(identity)|human orfeome collection:3202(identity)|ddbj/embl/genbank:BC002432(identity)|entrezgene/locuslink:8940(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:R4lom6gXvFXkkGF+Hj94m9ecsXA9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:EF58B32A576AD1CE|rigid:OCTghw1WUtzafCYh61EnRR17lKI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P00523 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-848039|uniprotkb:Q90992|uniprotkb:Q90993|uniprotkb:Q91343|uniprotkb:Q91345|uniprotkb:Q92013|uniprotkb:Q98915|ensembl:ENSGALP00000049896|ensembl:ENSGALP00000054990|ensembl:ENSGALP00000068298 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:src_chick(display_long)|uniprotkb:SRC(gene name)|psi-mi:SRC(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362141|imex:IM-22301-256 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_990788.2|dip:DIP-449N|refseq:XP_015151834.1|ensembl:ENSGALG00000003855(gene)|ensembl:ENSGALT00000061823(transcript)|ensembl:ENSGALT00000070498(transcript)|ensembl:ENSGALT00000093274(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0020037"(heme binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036035"(osteoclast development)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071253"(connexin binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P00523|rcsb pdb:1F1W|rcsb pdb:1F2F|rcsb pdb:1NLO|rcsb pdb:1NLP|rcsb pdb:1P13|rcsb pdb:1PRL|rcsb pdb:1PRM|rcsb pdb:1RLP|rcsb pdb:1RLQ|rcsb pdb:1SRL|rcsb pdb:1SRM|rcsb pdb:2HWO|rcsb pdb:2HWP|rcsb pdb:2OIQ|rcsb pdb:2PTK|rcsb pdb:2QI8|rcsb pdb:2QLQ|rcsb pdb:2QQ7|rcsb pdb:3D7T|rcsb pdb:3D7U|rcsb pdb:3DQW|rcsb pdb:3DQX|rcsb pdb:3EL7|rcsb pdb:3EL8|rcsb pdb:3EN4|rcsb pdb:3EN5|rcsb pdb:3EN6|rcsb pdb:3EN7|rcsb pdb:3F3T|rcsb pdb:3F3U|rcsb pdb:3F3V|rcsb pdb:3F3W|rcsb pdb:3F6X|rcsb pdb:3FJ5|rcsb pdb:3G5D|rcsb pdb:3G6G|rcsb pdb:3G6H|rcsb pdb:3GEQ|rcsb pdb:3LOK|rcsb pdb:3OEZ|rcsb pdb:3OF0|rcsb pdb:3QLF|rcsb pdb:3QLG|rcsb pdb:3SVV|rcsb pdb:3TZ7|rcsb pdb:3TZ8|rcsb pdb:3TZ9|rcsb pdb:3U4W|rcsb pdb:3U51|rcsb pdb:3UQF|rcsb pdb:3UQG|rcsb pdb:4AGW|rcsb pdb:4DGG|rcsb pdb:4FIC|rcsb pdb:4HVU|rcsb pdb:4HVV|rcsb pdb:4HVW|rcsb pdb:4JZ3|rcsb pdb:4JZ4|rcsb pdb:4LE9|rcsb pdb:4LGG|rcsb pdb:4LGH|rcsb pdb:4MCV|rcsb pdb:4O2P|rcsb pdb:4OML|rcsb pdb:4OMM|rcsb pdb:4OMN|rcsb pdb:4OMO|rcsb pdb:4OMP|rcsb pdb:4OMQ|rcsb pdb:4QT7|rcsb pdb:4RTU|rcsb pdb:4RTV|rcsb pdb:4RTW|rcsb pdb:4RTX|rcsb pdb:4RTY|rcsb pdb:4RTZ|rcsb pdb:4U5J|rcsb pdb:4YBJ|rcsb pdb:4YBK|rcsb pdb:5BMM|rcsb pdb:5D10|rcsb pdb:5D11|rcsb pdb:5D12|rcsb pdb:5EC7|rcsb pdb:5ECA|rcsb pdb:5I11|rcsb pdb:5J5S|rcsb pdb:5K9I|rcsb pdb:5OAV|rcsb pdb:5OB0|rcsb pdb:5OB1|rcsb pdb:5OB2|rcsb pdb:5SWH|rcsb pdb:5SYS|rcsb pdb:5T0P|rcsb pdb:5TEH|rcsb pdb:5XP5|rcsb pdb:5XP7|rcsb pdb:6HVE|rcsb pdb:6HVF|rcsb pdb:6L8L|rcsb pdb:6WIW|rcsb pdb:6XVM|rcsb pdb:6XVN|rcsb pdb:6XVO|rcsb pdb:6XX2|rcsb pdb:6XX3|rcsb pdb:6XX4|rcsb pdb:6XX5|reactome:R-GGA-1227986|reactome:R-GGA-1251985|reactome:R-GGA-1253288|reactome:R-GGA-1257604|reactome:R-GGA-1433557|reactome:R-GGA-180292|reactome:R-GGA-186763|reactome:R-GGA-191650|reactome:R-GGA-2029481|reactome:R-GGA-210990|reactome:R-GGA-354192|reactome:R-GGA-354194|reactome:R-GGA-372708|reactome:R-GGA-389356|reactome:R-GGA-389513|reactome:R-GGA-3928662|reactome:R-GGA-3928663|reactome:R-GGA-3928664|reactome:R-GGA-3928665|reactome:R-GGA-418592|reactome:R-GGA-418594|reactome:R-GGA-418885|reactome:R-GGA-430116|reactome:R-GGA-437239|reactome:R-GGA-4420097|reactome:R-GGA-456926|reactome:R-GGA-5218921|reactome:R-GGA-5674135|reactome:R-GGA-6811558|reactome:R-GGA-8853659|reactome:R-GGA-8874081|reactome:R-GGA-8941858|reactome:R-GGA-9009391|uniprotkb:P00523(identity)|entrezgene/locuslink:396442(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:4zMmRUOi44prLCXBJNuTuFIMkr49031 intact-crc:6B6DAB6653853424|rigid:mIBuQPemNh/SvfeHfpnp26haPgU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00524 uniprotkb:P07900 intact:EBI-2527426 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:src_rsvsa(display_long)|uniprotkb:V-SRC(gene name)|psi-mi:V-SRC(display_short)|uniprotkb:pp60v-src(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:269446(rsvsa)|taxid:269446("Avian leukosis virus RSA (RSV-SRA)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362159|imex:IM-22301-257 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|rcsb pdb:1BKL|rcsb pdb:1BKM|rcsb pdb:1IS0|rcsb pdb:1KC2|rcsb pdb:1NZL|rcsb pdb:1NZV|rcsb pdb:1SHA|rcsb pdb:1SHB|rcsb pdb:1SKJ|rcsb pdb:1SPR|rcsb pdb:1SPS|interpro:IPR036028|interpro:IPR036860|uniprotkb:P00524(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6zemhkpPD3DXoT54+QRehRFP5aU269446 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:B83300883BD9167F|rigid:fbG3YVtShbBRFujT6BzRiqcu7NM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00524 uniprotkb:Q16543 intact:EBI-2527426 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:src_rsvsa(display_long)|uniprotkb:V-SRC(gene name)|psi-mi:V-SRC(display_short)|uniprotkb:pp60v-src(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:269446(rsvsa)|taxid:269446("Avian leukosis virus RSA (RSV-SRA)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362177|imex:IM-22301-258 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|rcsb pdb:1BKL|rcsb pdb:1BKM|rcsb pdb:1IS0|rcsb pdb:1KC2|rcsb pdb:1NZL|rcsb pdb:1NZV|rcsb pdb:1SHA|rcsb pdb:1SHB|rcsb pdb:1SKJ|rcsb pdb:1SPR|rcsb pdb:1SPS|interpro:IPR036028|interpro:IPR036860|uniprotkb:P00524(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6zemhkpPD3DXoT54+QRehRFP5aU269446 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:C7A8E84570E1D918|rigid:yLksZHk8mZktb1Idy+AFtPuuRUE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P00524 intact:EBI-9356629 intact:EBI-2527426 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:src_rsvsa(display_long)|uniprotkb:V-SRC(gene name)|psi-mi:V-SRC(display_short)|uniprotkb:pp60v-src(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:269446(rsvsa)|taxid:269446("Avian leukosis virus RSA (RSV-SRA)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362194|imex:IM-22301-259 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|rcsb pdb:1BKL|rcsb pdb:1BKM|rcsb pdb:1IS0|rcsb pdb:1KC2|rcsb pdb:1NZL|rcsb pdb:1NZV|rcsb pdb:1SHA|rcsb pdb:1SHB|rcsb pdb:1SKJ|rcsb pdb:1SPR|rcsb pdb:1SPS|interpro:IPR036028|interpro:IPR036860|uniprotkb:P00524(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:6zemhkpPD3DXoT54+QRehRFP5aU269446 intact-crc:0E613728AA3943E7|rigid:pVMdyKoOhe2bnY4YSvLYyxv/+jc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P00533 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-297353|uniprotkb:Q9BZS2|uniprotkb:Q9GZX1|uniprotkb:Q9H2C9|uniprotkb:Q9H3C9|uniprotkb:Q9UMD7|uniprotkb:Q9UMD8|uniprotkb:Q9UMG5|uniprotkb:O00688|uniprotkb:O00732|uniprotkb:P06268|uniprotkb:Q14225|uniprotkb:Q92795|intact:EBI-28985169|ensembl:ENSP00000275493|uniprotkb:Q68GS5 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:egfr_human(display_long)|uniprotkb:ERBB1(gene name synonym)|uniprotkb:EGFR(gene name)|psi-mi:EGFR(display_short)|uniprotkb:Receptor tyrosine-protein kinase erbB-1(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-1(gene name synonym)|uniprotkb:ERBB(gene name synonym)|uniprotkb:HER1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362213|imex:IM-22301-260 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) ensembl:ENSG00000146648(gene)|ensembl:ENST00000275493(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001503"(ossification)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007494"(midgut development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035690"|go:"GO:0007611"(learning or memory)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0033594"(response to hydroxyisoflavone)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042698"(ovulation cycle)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043006"(activation of phospholipase A2 activity by calcium-mediated signaling)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010960"(magnesium ion homeostasis)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016101"(diterpenoid metabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032930"(positive regulation of superoxide anion generation)|rcsb pdb:4WD5|rcsb pdb:4WKQ|rcsb pdb:4WRG|rcsb pdb:4ZAU|rcsb pdb:4ZJV|rcsb pdb:4ZSE|rcsb pdb:5C8K|rcsb pdb:5C8M|rcsb pdb:5C8N|rcsb pdb:5CAL|rcsb pdb:5CAN|rcsb pdb:5CAO|rcsb pdb:5CAP|rcsb pdb:5CAQ|rcsb pdb:4UV7|rcsb pdb:5CAS|rcsb pdb:5CAU|rcsb pdb:5CAV|rcsb pdb:5CNN|rcsb pdb:5CNO|rcsb pdb:5CZH|rcsb pdb:5CZI|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051205"(protein insertion into membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|rcsb pdb:5UGB|rcsb pdb:5UGC|rcsb pdb:5UWD|rcsb pdb:5WB7|rcsb pdb:5WB8|rcsb pdb:5X26|rcsb pdb:5X27|rcsb pdb:5X28|rcsb pdb:5X2A|rcsb pdb:5X2C|rcsb pdb:5X2F|rcsb pdb:5X2K|rcsb pdb:5XDK|rcsb pdb:5XDL|rcsb pdb:5XGM|rcsb pdb:5XGN|rcsb pdb:5XWD|rcsb pdb:5Y25|rcsb pdb:5Y9T|rcsb pdb:5YU9|rcsb pdb:5ZTO|rcsb pdb:5ZWJ|rcsb pdb:6ARU|rcsb pdb:6B3S|rcsb pdb:5D41|rcsb pdb:6D8E|rcsb pdb:6DUK|rcsb pdb:6JRJ|rcsb pdb:6JRK|rcsb pdb:6JRX|rcsb pdb:6JWL|rcsb pdb:6JX0|rcsb pdb:6JX4|rcsb pdb:6JXT|rcsb pdb:6JZ0|go:"GO:0097489"(multivesicular body, internal vesicle lumen)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902722"(positive regulation of prolactin secretion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905208"(negative regulation of cardiocyte differentiation)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0070141"(response to UV-A)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097421"(liver regeneration)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|mint:P00533|rcsb pdb:1DNQ|rcsb pdb:1DNR|rcsb pdb:1IVO|rcsb pdb:1M14|rcsb pdb:1M17|rcsb pdb:1MOX|rcsb pdb:1NQL|rcsb pdb:1XKK|rcsb pdb:1YY9|rcsb pdb:1Z9I|rcsb pdb:2EB2|rcsb pdb:2EB3|rcsb pdb:2EXP|rcsb pdb:2EXQ|rcsb pdb:2GS2|rcsb pdb:2GS6|rcsb pdb:2J5E|rcsb pdb:2J5F|rcsb pdb:2GS7|rcsb pdb:2J6M|rcsb pdb:2JIT|rcsb pdb:2ITN|rcsb pdb:2JIU|rcsb pdb:2ITO|rcsb pdb:2JIV|rcsb pdb:2KS1|rcsb pdb:2ITP|rcsb pdb:2M0B|rcsb pdb:2M20|rcsb pdb:2ITQ|rcsb pdb:2N5S|rcsb pdb:2RF9|rcsb pdb:2RFD|rcsb pdb:2RFE|rcsb pdb:2RGP|rcsb pdb:3B2U|rcsb pdb:3B2V|rcsb pdb:3BEL|rcsb pdb:2ITT|rcsb pdb:3BUO|rcsb pdb:3C09|rcsb pdb:3G5V|rcsb pdb:3G5Y|rcsb pdb:3GOP|rcsb pdb:3GT8|rcsb pdb:3IKA|rcsb pdb:3LZB|rcsb pdb:2ITU|rcsb pdb:3NJP|rcsb pdb:3OB2|rcsb pdb:2ITV|rcsb pdb:3OP0|rcsb pdb:2ITW|rcsb pdb:2ITX|rcsb pdb:2ITY|rcsb pdb:3P0Y|rcsb pdb:2ITZ|rcsb pdb:3PFV|rcsb pdb:3POZ|rcsb pdb:3QWQ|rcsb pdb:3UG1|rcsb pdb:3UG2|rcsb pdb:3VJN|rcsb pdb:3VJO|rcsb pdb:3VRP|rcsb pdb:3VRR|rcsb pdb:5EM7|rcsb pdb:5EM8|rcsb pdb:5FED|rcsb pdb:5FEE|rcsb pdb:5FEQ|rcsb pdb:5GMP|rcsb pdb:5GNK|rcsb pdb:5GTY|rcsb pdb:5GTZ|rcsb pdb:5HCX|rcsb pdb:5HCY|rcsb pdb:5HCZ|rcsb pdb:5HG5|rcsb pdb:5HG7|rcsb pdb:5HG8|rcsb pdb:5HG9|rcsb pdb:5HIB|rcsb pdb:5HIC|rcsb pdb:5EDP|rcsb pdb:5J9Y|rcsb pdb:5J9Z|rcsb pdb:5JEB|rcsb pdb:5LV6|rcsb pdb:5SX4|rcsb pdb:5EDQ|rcsb pdb:5EDR|rcsb pdb:5EM5|rcsb pdb:5SX5|rcsb pdb:5U8L|rcsb pdb:5UG8|rcsb pdb:5EM6|rcsb pdb:5UG9|rcsb pdb:5UGA|rcsb pdb:3W2O|rcsb pdb:4JR3|rcsb pdb:3W2P|rcsb pdb:3W2Q|rcsb pdb:4JRV|rcsb pdb:4KRL|rcsb pdb:4KRM|rcsb pdb:4KRO|rcsb pdb:3W2R|rcsb pdb:4KRP|rcsb pdb:4LI5|rcsb pdb:4LL0|rcsb pdb:3W2S|rcsb pdb:4LQM|rcsb pdb:4LRM|rcsb pdb:3W32|rcsb pdb:4R3P|rcsb pdb:4R3R|rcsb pdb:4R5S|rcsb pdb:3W33|rcsb pdb:4RIW|rcsb pdb:4G5J|rcsb pdb:4RIX|rcsb pdb:4G5P|rcsb pdb:4RIY|rcsb pdb:4RJ4|rcsb pdb:4RJ5|rcsb pdb:4HJO|rcsb pdb:4I1Z|rcsb pdb:4I20|rcsb pdb:4I21|rcsb pdb:4I22|rcsb pdb:4I23|rcsb pdb:4I24|rcsb pdb:4JQ7|rcsb pdb:4JQ8|rcsb pdb:4RJ6|rcsb pdb:4RJ7|rcsb pdb:4RJ8|rcsb pdb:4TKS|rcsb pdb:4UIP|rcsb pdb:6LUD|rcsb pdb:6P1D|rcsb pdb:6P1L|rcsb pdb:6P8Q|rcsb pdb:6S89|rcsb pdb:6S8A|rcsb pdb:6S9B|rcsb pdb:6S9C|rcsb pdb:6S9D|rcsb pdb:6TFU|rcsb pdb:6LUB|rcsb pdb:6TFV|rcsb pdb:6TFW|rcsb pdb:6TFY|rcsb pdb:6TFZ|rcsb pdb:6TG0|rcsb pdb:6TG1|rcsb pdb:6V5N|rcsb pdb:6V5P|rcsb pdb:6V66|rcsb pdb:6V6K|rcsb pdb:6V6O|rcsb pdb:6VH4|rcsb pdb:6VHN|rcsb pdb:6VHP|rcsb pdb:6WA2|rcsb pdb:6WAK|rcsb pdb:6WXN|rcsb pdb:6XL4|rcsb pdb:6Z4B|rcsb pdb:6Z4D|rcsb pdb:7A2A|rcsb pdb:7AEI|rcsb pdb:7AEM|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-212718|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-445144|reactome:R-HSA-5637810|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-179812|reactome:R-HSA-8857538|reactome:R-HSA-8863795|reactome:R-HSA-9009391|reactome:R-HSA-9013507|reactome:R-HSA-9609690|reactome:R-HSA-9634638|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-8866910|refseq:NP_005219.2|refseq:NP_958439.1|refseq:NP_958440.1|refseq:NP_958441.1|ensembl:ENSP00000275493|ensembl:ENST00000342916|ensembl:ENSP00000342376|ensembl:ENST00000344576|ensembl:ENSP00000345973|ensembl:ENST00000420316|ensembl:ENSP00000413843|dip:DIP-405N|uniprotkb:P00533(identity)|human orfeome collection:71314(identity)|entrezgene/locuslink:1956(identity)|ddbj/embl/genbank:BC094761(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:gXB5slVTC+z8DdqqXIzXG7lDwk09606 intact-crc:9D4515C8AAE9368F|rigid:7F6QedClNb3JXiZaui0MtXh2354 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:P00540 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362233|imex:IM-22301-261 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:BBC02BE2997A55F3|rigid:2LKmMSpUfgAvD/5GNubHySNKjik false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:P58340 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362252|imex:IM-22301-262 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:C429AAAF383F1CCF|rigid:EFH5joN1y5snVLOWu7FSzZEH5aI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P00540 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362274|imex:IM-22301-263 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:3F2B056C89796B03|rigid:nVILYek7WefGH8QRPbxod5vUtJk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q6PK50 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-9356629 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362296|imex:IM-22301-264 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:93D7ED04A8996BBA|rigid:zsBOSQx+wED4bSHN6TkM3OlRuuw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q53FC7 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-9356749 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362318|imex:IM-22301-265 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:08B9284110B7220E|rigid:q80bD7r885vhTkxNed7O3cBiXj0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:P00540 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362340|imex:IM-22301-266 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:637F600F56DC647C|rigid:NDytvP4odAAnSEdqy8fpGVOWHPs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:P00540 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362359|imex:IM-22301-267 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:65CCC69756275E52|rigid:g9sHWscRPgWwi5/asU/YOeTIOpo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:P00540 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362378|imex:IM-22301-268 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:5368CBDBDE926610|rigid:uOdBLqMhhcpTZEguIbZ4EfhJv8c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P00540 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362400|imex:IM-22301-269 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:08F52AB8B24B051F|rigid:WjLsUy01bxKtbbm1ICmOZuo2yvI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:P00540 intact:EBI-9357028 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:b4dyc6_human(display_long) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362419|imex:IM-22301-270 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:0A9CFAA08906F2DF|rigid:Bbsd0PLiMql3yjXnfRNQWkgQX+Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q13200 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362439|imex:IM-22301-271 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:F204F5E84686CA1F|rigid:yG96JxSAteKDsT441xtZ0vBGQe0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:P00540 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362461|imex:IM-22301-272 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:F592DE50FFF57D34|rigid:C+iSNv6SXHPvTqsRDU7eO2+72NY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q719I0 uniprotkb:P00540 intact:EBI-9361704|uniprotkb:Q8NDU5|uniprotkb:D6W5E0|uniprotkb:B3KS51 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:ahsa2_human(display_long)|uniprotkb:AHSA2P(gene name)|psi-mi:AHSA2P(display_short)|uniprotkb:AHSA2(gene name synonym)|uniprotkb:Activator of HSP90 ATPase homolog 2 pseudogene(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362483|imex:IM-22301-273 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR023393|refseq:NP_001308229.1|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|refseq:NP_689605.1|interpro:IPR036338|interpro:IPR039981|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:Q719I0(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cKfjoKsqFsak3gNl4dGt8OXDhtg9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:C1BD92A661E5CC4E|rigid:Yb6JLVGPPhdPDyPknCd5+ABbgTc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P00540 intact:EBI-9356686 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:q96be0_human(display_long) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362502|imex:IM-22301-274 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:434EF388E47D1573|rigid:8JZG2PwTbA5TwPvt9W2K8y36EaE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:P07900 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362524|imex:IM-22301-275 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:428AC2F063476AD4|rigid:FtTq8QWw8A91W7cyVNyX0Zh+hjE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:P31948 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362545|imex:IM-22301-276 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:2D2D16A833994548|rigid:n9XWYs8IJWG2mbrLTNuKQQq47Rk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q9UIM3 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362564|imex:IM-22301-277 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:E97F57C67495E2E4|rigid:LntTbdT/5iuGKBjow/N01JueIqI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q16543 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362583|imex:IM-22301-278 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:393AF8F869C3868C|rigid:8N2aZ5Sbvw5rX6kBT/v+Gwq7v4I false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q9UNE7 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362603|imex:IM-22301-279 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:8B52347E5B6560AD|rigid:X7+RpvD4pDqQsrAsilIFF8Z0ciw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P00540 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362625|imex:IM-22301-280 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:9E055B0A500CA514|rigid:0uSQzAV49B9LlUBHHmDIIpbPvdc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P00540 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362644|imex:IM-22301-281 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 intact-crc:11BB4CF929467F86|rigid:IKf+4pAJ8wW+LEYrZST2S0bRR+I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q9BPW0 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-9356778 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362666|imex:IM-22301-282 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:E8DA93C58813B9FF|rigid:8moMzXycmO4zvlCtAhzH5naHMVM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q99614 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362688|imex:IM-22301-283 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:8A2EAD88F79A6827|rigid:3c9YSk142gr5kRDjwL2cueA3A3k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00540 uniprotkb:Q53HB3 intact:EBI-1757866|uniprotkb:Q3KPH0|uniprotkb:Q3KPG9|ensembl:ENSP00000310722 intact:EBI-9362707 psi-mi:mos_human(display_long)|uniprotkb:MOS(gene name)|psi-mi:MOS(display_short)|uniprotkb:Oocyte maturation factor mos(gene name synonym)|uniprotkb:Proto-oncogene c-Mos(gene name synonym) psi-mi:q53hb3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362710|imex:IM-22301-284 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005363.1|ensembl:ENSG00000172680(gene)|ensembl:ENST00000311923(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0007165"(signal transduction)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051296"(establishment of meiotic spindle orientation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902103"(negative regulation of metaphase/anaphase transition of meiotic cell cycle)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P00540|uniprotkb:P00540(identity)|entrezgene/locuslink:4342(identity)|ddbj/embl/genbank:BC069569(identity)|human orfeome collection:13876(identity) interpro:IPR035244|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|uniprotkb:Q53HB3(identity)|ddbj/embl/genbank:BC000512(identity)|entrezgene/locuslink:5700(identity)|human orfeome collection:4018(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FWcIP3b1RNgamfa9NUiyOKdk+dI9606 rogid:Unfk3E8DIsBKU/b5AIjm4wDR26M9606 intact-crc:B76E87BBBEB63E0F|rigid:rzw9EKgx9qAdkWhA3W6QXQoMd9Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:P58340 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362732|imex:IM-22301-285 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:5E81795BF6B11270|rigid:Gtt9AacP4etmD0y+QeJb+2Qqk2s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q15773 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362754|imex:IM-22301-286 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:D79FB60123E036F0|rigid:RGlP9ThuftqHlUDudM4UmYbt8FM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q6PK50 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-9356629 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362776|imex:IM-22301-287 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:1C7E590F79356515|rigid:f9TWcbY+BWes3rEAJvLKsIhL8nE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q53FC7 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-9356749 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362798|imex:IM-22301-288 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:52C654E727FCD0C8|rigid:cJbVKRqAMuZoaIxJFK0J6MSaIiQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:P04049 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362820|imex:IM-22301-289 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:6451A4ED50002D6E|rigid:tLX2hH0oR5gBR8NbHJpK87FkPpI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q8IVD9 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362842|imex:IM-22301-290 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:ECAFFFB84E17CD34|rigid:JEIUN+bD17ZEKUQBZjzJy6Au6kY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:B4DYC6 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-9357028 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362861|imex:IM-22301-291 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:351B7663A79FE9FA|rigid:Fe5VprqyXH+4vNP9Hnj2uvfLQXs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q13200 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362881|imex:IM-22301-292 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:28F303D1AAC6666C|rigid:E0IV8141E5zgglrYtY1K3SUCxHA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P04049 intact:EBI-9356686 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:q96be0_human(display_long) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362903|imex:IM-22301-293 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:DB70D8016F12B167|rigid:QPEab9YrMZlbudHb4trQW5HHlP8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:P07900 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362925|imex:IM-22301-294 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:383ABA697EB92E81|rigid:fXQyhTIwwi2+jc6VUw4o0xhIIb0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:P04049 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362946|imex:IM-22301-295 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:BE7DFCADB3AF3397|rigid:2Ed9onzZGEfvvg4Cz5BwN2K19mQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q9UIM3 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362965|imex:IM-22301-296 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:645469BBB4F502BB|rigid:6VqnB4FcNIy2r+9qxru+bcpoWbg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q16543 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9362984|imex:IM-22301-297 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:29D57E5E172C1719|rigid:LcU4suXK3+H7dkvXg+IMLlsgh28 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q9UNE7 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363004|imex:IM-22301-298 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:FFFD6A7056D2B97C|rigid:yF2dq39+yAgck8Lyzm4WRoI6wxc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q9HB71 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363026|imex:IM-22301-299 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:B80ECADE743F3BF6|rigid:gd2zSLI4qU5Gc0bl34JDe29JSks false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P04049 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363045|imex:IM-22301-300 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:A66FB724E4267231|rigid:0tEcuH/xjIjqLQARIOr0ek0ayb8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04049 uniprotkb:Q9BPW0 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 intact:EBI-9356778 psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363067|imex:IM-22301-301 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|human orfeome collection:732(identity)|ddbj/embl/genbank:BC018119(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:223C62D50EF81597|rigid:gmvfF+aWkKWbNeGqmKlowFdNkso false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P04350 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363089|imex:IM-22301-302 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|human orfeome collection:6055(identity)|ddbj/embl/genbank:BC006570(identity)|entrezgene/locuslink:10382(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 intact-crc:1082CAC4FB41D5EE|rigid:YzHvjUS9j02l8VlmLAcZBfcbKvY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P04350 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363110|imex:IM-22301-303 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|human orfeome collection:6055(identity)|ddbj/embl/genbank:BC006570(identity)|entrezgene/locuslink:10382(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 intact-crc:3A4EB7EFC11EAAED|rigid:1Zdk/qP6Rk8hTByk4MZhWBLzGXw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04350 uniprotkb:Q13200 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363132|imex:IM-22301-304 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|human orfeome collection:6055(identity)|ddbj/embl/genbank:BC006570(identity)|entrezgene/locuslink:10382(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:F59AD0BF831ED289|rigid:Nny+Kg2wos517hL0ctcaZAFUj7c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04350 uniprotkb:Q9BTE6-2 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363154|imex:IM-22301-305 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|human orfeome collection:6055(identity)|ddbj/embl/genbank:BC006570(identity)|entrezgene/locuslink:10382(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:F001D359200A8A1B|rigid:J2GDZIqk6l0Y2HTqnxOMoUB/oNs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q13451 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363176|imex:IM-22301-306 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:4201CBD135D05958|rigid:rPxVimHXdinn8DH332SfK2HGge0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q16543 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363193|imex:IM-22301-307 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:FDECDC86A8FEBA30|rigid:QUvpj0V7p0jdGi5KOoLBZjLZ75A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q3UJD6-1 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363211|imex:IM-22301-308 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:82EAF1ECAAD7959E|rigid:+qg/rEugAu4xZQ3WYzCsc9XqLRI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q6PK50 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-9356629 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363230|imex:IM-22301-309 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:C057666713F26828|rigid:85HVZdoy8j/vivJBKLyoMMifx+c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:P04626 intact:EBI-9356778 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363250|imex:IM-22301-310 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:786800252BAED660|rigid:AhNqzlPv2CfUhpGr3MTkm0C1IQ8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P04626 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363270|imex:IM-22301-311 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:BA8B6385FA726416|rigid:OO56MSRgP9RP0X7mBcqMuTSyLeA false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:654-654,659-659("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q9BTE6-2 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363294|imex:IM-22301-312 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:68357BCEFFAA2B47|rigid:O/qQrtgaiUQmiYnVTVQJEI6UAvI false mutation increasing interaction:654-654,659-659("MI:0382")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q9Y266 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363318|imex:IM-22301-313 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:95FE363BD6ABCD81|rigid:m3tZBXd7x1bUSShE+gElNVtes2k false flag tag:c-c("MI:0518")|mutation increasing interaction:654-654,659-659("MI:0382") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q13200 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363339|imex:IM-22301-314 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:8B5C9AAC0493D5A9|rigid:LtmQntdpEDZH3eej/Yz57xruzg8 false mutation increasing interaction:654-654,659-659("MI:0382")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWX7 uniprotkb:P04626 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363369|imex:IM-22301-315 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:9DF97A0955CEA628|rigid:46P4OLPVIMW5vPvorPnMGuPMUzo false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:654-654,659-659("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:P04626 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363393|imex:IM-22301-316 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:A038D472F9AE899F|rigid:xyrFgJ0RYGN9Wnf/O16S033Y4gE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518")|mutation increasing interaction:654-654,659-659("MI:0382") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P04626 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363414|imex:IM-22301-317 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:CA32995CDD0CC1AC|rigid:kVLcOtnp2++jQR+jDTInBSIoQbo false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:654-654,659-659("MI:0382")|mutation increasing interaction:659-659,753-753("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:P04626 intact:EBI-9357028 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:b4dyc6_human(display_long) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363439|imex:IM-22301-318 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:C6EA91CF05B8B943|rigid:j64LMuNYdKnjJGuftbkATNb/Zr8 false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:659-659,753-753("MI:0382")|mutation increasing interaction:654-654,659-659("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q96BE0 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-9356686 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363465|imex:IM-22301-319 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1179CBDDD476B74A|rigid:U0QSMULnJCIWfeLRQU0zVsg3+P8 false mutation increasing interaction:659-659,753-753("MI:0382")|flag tag:c-c("MI:0518")|mutation increasing interaction:654-654,659-659("MI:0382") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P04626 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363493|imex:IM-22301-320 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:9AC9DD6FD010237E|rigid:tvl3ZfBcptOjh/pEDsLrqzZyv8I false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:654-654,659-659("MI:0382")|mutation increasing interaction:659-659,753-753("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:P04626 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363518|imex:IM-22301-321 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:74635585478129C6|rigid:nltAyUjyTYmj3kDAH1qU5BtB2Tc false renilla luciferase protein tag:c-c("MI:0896") mutation increasing interaction:659-659,753-753("MI:0382")|flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04626 uniprotkb:Q15773 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363541|imex:IM-22301-322 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:B15A06849D2C6698|rigid:wDSH1Kf6ahLliB8rcDNdxogPPyE false mutation increasing interaction:659-659,753-753("MI:0382")|flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:P04626 intact:EBI-9356749 intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5 psi-mi:q53fc7_human(display_long) psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363565|imex:IM-22301-323 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1|uniprotkb:P04626(identity)|entrezgene/locuslink:2064(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606 intact-crc:4FE2A53E3198F3C7|rigid:9ImaImSGJ+XmE4DrSsrmGN7VI6Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518")|mutation increasing interaction:659-659,753-753("MI:0382") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04792 uniprotkb:P04792 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363589|imex:IM-22301-324 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|entrezgene/locuslink:3315(identity)|ddbj/embl/genbank:BC012292(identity)|human orfeome collection:618(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|entrezgene/locuslink:3315(identity)|ddbj/embl/genbank:BC012292(identity)|human orfeome collection:618(identity) psi-mi:"MI:0469"(intact) crc64:1B4DC44A6F6606D5 crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:F2427B750AB937C3|rigid:67eYAIyvIlZ4GbyVG3zP7g3h5UY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:P07900 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363611|imex:IM-22301-325 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:0664CFEC6761FF3B|rigid:t9h6FVXbKXkDXcLO4DUB/tQ4Q6s false renilla luciferase protein tag:c-c("MI:0896") flag tag:n-n("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q6PK50 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-9356629 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363630|imex:IM-22301-326 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|entrezgene/locuslink:3320(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:931BBF16218D88A6|rigid:lw/M3pEbo57+nghkadgyfhluink false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q7L3B6 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363650|imex:IM-22301-327 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|entrezgene/locuslink:3320(identity) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 intact-crc:38AC8A5161F15A8B|rigid:hZt3mUkUragDV8v3Jj3OHXsFMhQ false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07947 uniprotkb:Q16543 intact:EBI-515331|uniprotkb:A6NLB3|uniprotkb:D3DUH1|intact:EBI-28995389|ensembl:ENSP00000324740|ensembl:ENSP00000462468 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:yes_human(display_long)|uniprotkb:p61-Yes(gene name synonym)|uniprotkb:Proto-oncogene c-Yes(gene name synonym)|uniprotkb:YES1(gene name)|psi-mi:YES1(display_short)|uniprotkb:YES(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363670|imex:IM-22301-328 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016881449.1|refseq:NP_005424.1|ensembl:ENSP00000324740|ensembl:ENSP00000462468|dip:DIP-33849N|ensembl:ENSG00000176105(gene)|ensembl:ENST00000314574(transcript)|ensembl:ENST00000584307(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035751|interpro:IPR036028|interpro:IPR036860|mint:P07947|rcsb pdb:2HDA|reactome:R-HSA-1227986|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2682334|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-8940973|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9670439|uniprotkb:P07947(identity)|ddbj/embl/genbank:BC048960(identity)|human orfeome collection:10705(identity)|entrezgene/locuslink:7525(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Wo+NWxPVSmF8W6ZHQmTPpg3YuY09606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:2C06FB0769846D41|rigid:4aXvnGVLIschcssV/EXqkX5KRWU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P08913 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363690|imex:IM-22301-329 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N|uniprotkb:P08913(identity)|human orfeome collection:11564(identity)|ddbj/embl/genbank:BC035047(identity)|entrezgene/locuslink:150(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/01/08 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606 intact-crc:C802A44951B2FE84|rigid:rh33GfiNwZfhxocMRu5Xu6+Ek24 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08913 uniprotkb:Q13200 intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363711|imex:IM-22301-330 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N|uniprotkb:P08913(identity)|human orfeome collection:11564(identity)|ddbj/embl/genbank:BC035047(identity)|entrezgene/locuslink:150(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/01/08 rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:85F2978786EB72BE|rigid:UtWL/sIol9xZtvDIfeCOgscpTyM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08913 uniprotkb:Q3UJD6-2 intact:EBI-6622671|ensembl:ENSP00000280155|uniprotkb:B0LPF6|uniprotkb:Q2I8G2|uniprotkb:Q2XN99|uniprotkb:Q86TH8|uniprotkb:Q9BZK1 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:ada2a_human(display_long)|uniprotkb:ADRA2A(gene name)|psi-mi:ADRA2A(display_short)|uniprotkb:ADRA2R(gene name synonym)|uniprotkb:ADRAR(gene name synonym)|uniprotkb:Alpha-2 adrenergic receptor subtype C10(gene name synonym)|uniprotkb:Alpha-2A adrenoreceptor(gene name synonym) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363733|imex:IM-22301-331 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000150594(gene)|ensembl:ENST00000280155(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004938"(alpha2-adrenergic receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030168"(platelet activation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032811"(negative regulation of epinephrine secretion)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035624"(receptor transactivation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042596"(fear response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0071881"(adenylate cyclase-inhibiting adrenergic receptor signaling pathway)|go:"GO:0071882"(phospholipase C-activating adrenergic receptor signaling pathway)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001946(Adrenergic receptor, alpha-2A)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1HLL|rcsb pdb:1HO9|rcsb pdb:1HOD|rcsb pdb:1HOF|rcsb pdb:6K42|rcsb pdb:6KUX|rcsb pdb:6KUY|reactome:R-HSA-390696|reactome:R-HSA-392023|reactome:R-HSA-400042|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-5683826|refseq:NP_000672.3|dip:DIP-61452N|uniprotkb:P08913(identity)|human orfeome collection:11564(identity)|ddbj/embl/genbank:BC035047(identity)|entrezgene/locuslink:150(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/01/08 rogid:U+fZeOEBa5ofBs8XfKYhxPYeNhY9606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:0337068C5418FF62|rigid:nboo5HfSlJLfh5zVhFJTTDkRz48 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10276 uniprotkb:Q9UKP3 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363754|imex:IM-22301-332 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N|uniprotkb:P10276(identity)|ddbj/embl/genbank:BC008727(identity)|human orfeome collection:4558(identity)|entrezgene/locuslink:5914(identity) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 intact-crc:B5E7EB9C65165911|rigid:z+zhypsHs0T8tBhwlp0JufC2CZw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P55036 uniprotkb:P11908 intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879 intact:EBI-4290895|uniprotkb:Q0VDH9|uniprotkb:Q0VDI0|uniprotkb:Q15245|uniprotkb:Q2TAK7|ensembl:ENSP00000370043 psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym) psi-mi:prps2_human(display_long)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase II(gene name synonym)|uniprotkb:PRPS2(gene name)|psi-mi:PRPS2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363773|imex:IM-22301-333 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|uniprotkb:P55036(identity) refseq:NP_001034180.1|refseq:NP_002756.1|ensembl:ENSG00000101911(gene)|ensembl:ENST00000380668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|mint:P11908|reactome:R-HSA-73843|uniprotkb:P11908(identity)|human orfeome collection:56559(identity)|ddbj/embl/genbank:BC119662(identity)|entrezgene/locuslink:5634(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606 rogid:0xrvWRbZcFgGYCIUnf0XtqHvJ9E9606 intact-crc:EC77AD5A8D3FB17D|rigid:jg1gka8IGVTG728AuLBVk/DrA9Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:P11908 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-4290895|uniprotkb:Q0VDH9|uniprotkb:Q0VDI0|uniprotkb:Q15245|uniprotkb:Q2TAK7|ensembl:ENSP00000370043 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:prps2_human(display_long)|uniprotkb:PPRibP(gene name synonym)|uniprotkb:Phosphoribosyl pyrophosphate synthase II(gene name synonym)|uniprotkb:PRPS2(gene name)|psi-mi:PRPS2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363792|imex:IM-22301-334 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_001034180.1|refseq:NP_002756.1|ensembl:ENSG00000101911(gene)|ensembl:ENST00000380668(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|mint:P11908|reactome:R-HSA-73843|uniprotkb:P11908(identity)|human orfeome collection:56559(identity)|ddbj/embl/genbank:BC119662(identity)|entrezgene/locuslink:5634(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:0xrvWRbZcFgGYCIUnf0XtqHvJ9E9606 intact-crc:C500553301CBF287|rigid:oQ4sWhB23ufiRGL2/56hJoowjYY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15185 uniprotkb:P13667 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363814|imex:IM-22301-335 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV|uniprotkb:P13667(identity)|ddbj/embl/genbank:BC000425(identity)|entrezgene/locuslink:9601(identity)|human orfeome collection:3134(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:3A5BED0BB4840107|rigid:+SuKL7HHPat3+NOPU4a6TinhncA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q13451 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363834|imex:IM-22301-336 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:518260E26B9214BB|rigid:m8eKlJDppHR4vevloaGuV0WQLo4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q6PK50 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-9356629 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363853|imex:IM-22301-337 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:D3A5F333C87EB17D|rigid:jm5Qh+eX2ZPFdBrZ3wv4htxujSY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q9Y266 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363875|imex:IM-22301-338 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:A79BDC400207201D|rigid:ObZgbKS6/45+ujMMIL/Q9XZJq9c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P15918 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363894|imex:IM-22301-339 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 intact-crc:9F82C63839702868|rigid:+HCwTB/CbMtGhc2AdEVTuPCwpac false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:B4DYC6 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-9357028 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363913|imex:IM-22301-340 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:A7A815F8541FB1E6|rigid:XFs9n5gY0qlSYLngruZIiYVWxd0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q96BE0 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-9356686 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363933|imex:IM-22301-341 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:EF821AB755E2DF8F|rigid:KVuQFuy7QMIa+us1bmtuQaJ++Lk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q9HB71 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363955|imex:IM-22301-342 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:DD90E9CBD803DAA5|rigid:WS8ac7X9FtQji77RKfT9VveKsaA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q15185 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363974|imex:IM-22301-343 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:355C915B22231112|rigid:u5KBR4txctoeEGLdQQprp9bJeyc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15918 uniprotkb:Q9BPW0 intact:EBI-1755109|uniprotkb:Q8NER2|uniprotkb:E9PPC4|uniprotkb:Q8IY72|ensembl:ENSP00000299440 intact:EBI-9356778 psi-mi:rag1_human(display_long)|uniprotkb:RAG1(gene name)|psi-mi:RAG1(display_short)|uniprotkb:RNF74(gene name synonym)|uniprotkb:RING finger protein 74(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9363994|imex:IM-22301-344 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011518552.1|refseq:NP_000439.1|refseq:XP_005253098.1|ensembl:ENSG00000166349(gene)|ensembl:ENST00000299440(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006310"(DNA recombination)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0097519"(DNA recombinase complex)|go:"GO:1905347"(endodeoxyribonuclease complex)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR019485|interpro:IPR023336|interpro:IPR024627|interpro:IPR035714|interpro:IPR036236|reactome:R-HSA-1266695|reactome:R-HSA-5687128|uniprotkb:P15918(identity)|ddbj/embl/genbank:BC037344(identity)|entrezgene/locuslink:5896(identity)|human orfeome collection:10437(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UDADPdUVxpN7sRIkwgKLVk1OR8M9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:F018BCD14F1FED16|rigid:6kLcUX2VY4uA+iH1YHOredksz5o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16615 uniprotkb:Q9BPW0 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 intact:EBI-9356778 psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364016|imex:IM-22301-345 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N|uniprotkb:P16615(identity)|entrezgene/locuslink:488(identity)|human orfeome collection:10050(identity)|ddbj/embl/genbank:BC035588(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:9D91764D72C48CA7|rigid:0uE6SLm7MeOljcQWgyoaNnaXNhg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P18074 intact:EBI-9356629 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364038|imex:IM-22301-346 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 intact-crc:BDC9488D95393456|rigid:XtpRMyEZ4+yZfmLackJuMKsD7Kg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:P18074 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364060|imex:IM-22301-347 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 intact-crc:E66D0804DA3270E2|rigid:HOUgL2o+/RUWbkJyTRp6mophjYA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P18074 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364079|imex:IM-22301-348 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 intact-crc:62D5247BC8210420|rigid:rqqgmLfxeInf8r1IAlyg+unonpY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18074 uniprotkb:B4DYC6 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 intact:EBI-9357028 psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364098|imex:IM-22301-349 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:95E64BD09639AA0C|rigid:IWTL+UHA123g3sKNt1VEJb0Qsac false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18074 uniprotkb:Q96BE0 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 intact:EBI-9356686 psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364118|imex:IM-22301-350 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:A8CB32C1496B2286|rigid:Ud7XJCQFWtpTAuhzw1vbr7tSnrQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18074 uniprotkb:P31948 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364140|imex:IM-22301-351 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:1227C340947195C4|rigid:l6vT1bygfI8Jev0hrd0ZpDBSjsg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P18074 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364159|imex:IM-22301-352 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 intact-crc:E3A139711CBAC85B|rigid:cOjugA+kRuR5RNllq7K/E3sZ99c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18074 uniprotkb:Q9BTE6-2 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364178|imex:IM-22301-353 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:2ABF8DEAA5540000|rigid:kgTBwtYIWj+iLuhhGTkRG4KpPac false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18074 uniprotkb:Q9BPW0 intact:EBI-6380590|ensembl:ENSP00000375809|ensembl:ENSP00000507019|uniprotkb:Q2TB78|uniprotkb:Q2YDY2|uniprotkb:Q7KZU6|uniprotkb:Q8N721 intact:EBI-9356778 psi-mi:ercc2_human(display_long)|uniprotkb:ERCC2(gene name)|psi-mi:ERCC2(display_short)|uniprotkb:XPD(gene name synonym)|uniprotkb:XPDC(gene name synonym)|uniprotkb:Basic transcription factor 2 80 kDa subunit(gene name synonym)|uniprotkb:CXPD(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-2(gene name synonym)|uniprotkb:DNA repair protein complementing XP-D cells(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 80 kDa subunit(gene name synonym)|uniprotkb:Xeroderma pigmentosum group D-complementing protein(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364200|imex:IM-22301-354 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104884(gene)|ensembl:ENST00000391945(transcript)|ensembl:ENST00000682414(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0009791"(post-embryonic development)|go:"GO:0021510"(spinal cord development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032289"(central nervous system myelin formation)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045951"(positive regulation of mitotic recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0071817"(MMXD complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|interpro:IPR001945(Xeroderma pigmentosum group D protein)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR010643(Protein of unknown function DUF1227)|go:"GO:0006915"(apoptotic process)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|interpro:IPR027417|mint:P18074|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:6TUN|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-2564830|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|dip:DIP-644N|refseq:NP_000391.1|refseq:NP_001124339.1|uniprotkb:P18074(identity)|entrezgene/locuslink:2068(identity)|ddbj/embl/genbank:BC110523(identity)|human orfeome collection:56163(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zZKINZxsFZY4rkmg9VNqc4rTTjQ9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:D7BA845156331507|rigid:C4+XNw1g71dvX70CkfMHbs71XCg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P18505 uniprotkb:Q13451 intact:EBI-3914848|uniprotkb:Q16166|uniprotkb:B2R6U7|uniprotkb:Q8TBK3|ensembl:ENSP00000295454|uniprotkb:D6REL3 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:gbrb1_human(display_long)|uniprotkb:GABRB1(gene name)|psi-mi:GABRB1(display_short)|uniprotkb:"GABA(A) receptor subunit beta-1"(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364222|imex:IM-22301-355 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000803.2|ensembl:ENSG00000163288(gene)|ensembl:ENST00000295454(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009636"(response to toxic substance)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0050877"(nervous system process)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002289(Gamma-aminobutyric-acid A receptor, beta subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-1236394|reactome:R-HSA-977443|uniprotkb:P18505(identity)|ddbj/embl/genbank:BC022449(identity)|entrezgene/locuslink:2560(identity)|human orfeome collection:1133(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FE1ChS7kAAGDgLl7T1Leze/bsQw9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:B7E1F6AA5959AAF5|rigid:iriZ3fQ1qv8lC1+j/XevAJTtsuc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19086 uniprotkb:P58340 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364241|imex:IM-22301-356 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:BF142DFBE2991A4E|rigid:HK3rcrsiPck9vAd8AHLHLflnBvw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19086 uniprotkb:Q15773 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364263|imex:IM-22301-357 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:A6341568AACF9646|rigid:gzDkVjnqSBepKGX+QIDjWt3O8jA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19086 uniprotkb:Q8IVD9 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364285|imex:IM-22301-358 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:CCA37E490FC3BBF8|rigid:aUaBnNYYxmyUVL0Kbd04QkoOL/E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P19086 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364304|imex:IM-22301-359 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:836607FF79DE762A|rigid:yxi+xzZZhzU95kz0uhPRO6dllyk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P19086 intact:EBI-9356686 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:q96be0_human(display_long) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364326|imex:IM-22301-360 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:B3FC3EE8F3145D43|rigid:CHImBcWc/Q5/KWKRToLyPb0mdAk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:P19086 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364348|imex:IM-22301-361 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:FC1BAC6AB515F0B0|rigid:6HuJahoEz1nN0Z48nMWT3ZyFVMc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:P19086 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364367|imex:IM-22301-362 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:BA5001526A3606A2|rigid:L3qfNk4lgrhK9sruGlermmoMqpI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P19086 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364386|imex:IM-22301-363 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:F69D54702771A79A|rigid:3KXHIffCo59NpU3cAbT8TeC+CtQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P19086 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9071731|ensembl:ENSP00000478892|uniprotkb:Q4QRJ6|uniprotkb:B2R6C1 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:gnaz_human(display_long)|uniprotkb:"G(x) alpha chain"(gene name synonym)|uniprotkb:Gz-alpha(gene name synonym)|uniprotkb:GNAZ(gene name)|psi-mi:GNAZ(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364405|imex:IM-22301-364 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_002064.1|ensembl:ENSG00000128266(gene)|ensembl:ENST00000615612(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-418555|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-9660821|uniprotkb:P19086(identity)|ddbj/embl/genbank:BC026342(identity)|entrezgene/locuslink:2781(identity)|human orfeome collection:1223(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:q6aYF1TkNLkemfCVZBdijhHeMf09606 intact-crc:594CD5686B8CEA33|rigid:qtfoEJHTdrZXRELSWezLzJNOjPM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P19447 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364427|imex:IM-22301-365 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N|uniprotkb:P19447(identity)|human orfeome collection:4854(identity)|entrezgene/locuslink:2071(identity)|ddbj/embl/genbank:BC008820(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606 intact-crc:C9A0D4A6489528F8|rigid:vNq6jVeYSO05mcK41hS7A0Isu7M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19447 uniprotkb:Q15773 intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364449|imex:IM-22301-366 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N|uniprotkb:P19447(identity)|human orfeome collection:4854(identity)|entrezgene/locuslink:2071(identity)|ddbj/embl/genbank:BC008820(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:E15A47EE6486838C|rigid:0p/bAzUoS40LdX8dmMnU9AK+veU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19447 uniprotkb:B4DYC6 intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398 intact:EBI-9357028 psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364471|imex:IM-22301-367 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N|uniprotkb:P19447(identity)|human orfeome collection:4854(identity)|entrezgene/locuslink:2071(identity)|ddbj/embl/genbank:BC008820(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:AF653D4A79309390|rigid:8FEpoKcrWhKhE+RFIG3Ga8RGuvQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19447 uniprotkb:Q9UNE7 intact:EBI-1183307|uniprotkb:Q53QM0|ensembl:ENSP00000285398 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:ercc3_human(display_long)|uniprotkb:ERCC3(gene name)|psi-mi:ERCC3(display_short)|uniprotkb:XPB(gene name synonym)|uniprotkb:XPBC(gene name synonym)|uniprotkb:Basic transcription factor 2 89 kDa subunit(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex 89 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein complementing XP-B cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group B-complementing protein(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-3(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364491|imex:IM-22301-368 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000113.1|ensembl:ENSG00000163161(gene)|ensembl:ENST00000285398(transcript)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0000717"(nucleotide-excision repair, DNA duplex unwinding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006265"(DNA topological change)|go:"GO:0006281"(DNA repair)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048568"(embryonic organ development)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001161("Xeroderma pigmentosum group B protein (XP-B)")|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032438|interpro:IPR032830|mint:P19447|rcsb pdb:4ERN|rcsb pdb:5IVW|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5OF4|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6RO4|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVV|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|go:"GO:0000112"(nucleotide-excision repair factor 3 complex)|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-73863|dip:DIP-83N|uniprotkb:P19447(identity)|human orfeome collection:4854(identity)|entrezgene/locuslink:2071(identity)|ddbj/embl/genbank:BC008820(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KOM9+f636LHK8qfTFkLIm0X0VoY9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:3F677CD1F619DFC7|rigid:SmABJTK0AQzscHk8q8cwykoKPlE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19474 uniprotkb:Q6PK50 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 intact:EBI-9356629 psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364513|imex:IM-22301-369 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|uniprotkb:P19474(identity)|ddbj/embl/genbank:BC010861(identity)|human orfeome collection:130(identity)|entrezgene/locuslink:6737(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:589D0D97F056A37E|rigid:UYJ2gN195ITfvdrv9smn08hH5lc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20794 uniprotkb:Q16543 intact:EBI-3911321|uniprotkb:Q9NUH7|uniprotkb:F1T0K6|uniprotkb:G1FL29|uniprotkb:Q547D0|ensembl:ENSP00000313021|ensembl:ENSP00000476067 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:mak_human(display_long)|uniprotkb:MAK(gene name)|psi-mi:MAK(display_short)|uniprotkb:Male germ cell-associated kinase(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364535|imex:IM-22301-370 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005897.1|refseq:XP_011512921.1|refseq:XP_011512922.1|refseq:XP_011512924.1|refseq:NP_001229314.1|refseq:NP_001229886.1|ensembl:ENSG00000111837(gene)|ensembl:ENST00000313243(transcript)|ensembl:ENST00000474039(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030496"(midbody)|go:"GO:0031514"(motile cilium)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902856"(negative regulation of non-motile cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:XP_016866352.1|refseq:XP_016866353.1|uniprotkb:P20794(identity)|ddbj/embl/genbank:BC039825(identity)|entrezgene/locuslink:4117(identity)|human orfeome collection:10316(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iQZUfQy6U56KxyAhMZrev3DnpNc9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:70F1A4E8FB54F1E0|rigid:AxMcKmlmFs92ngBB0RG6CmGP2R0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75344 uniprotkb:P22059 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-2681902|uniprotkb:Q6P524|ensembl:ENSP00000263847 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:osbp1_human(display_long)|uniprotkb:OSBP1(gene name synonym)|uniprotkb:OSBP(gene name)|psi-mi:OSBP(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364555|imex:IM-22301-371 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) refseq:NP_002547.1|ensembl:ENSG00000110048(gene)|ensembl:ENST00000263847(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|go:"GO:1904411"(positive regulation of secretory granule organization)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:2RR3|reactome:R-HSA-1660661|reactome:R-HSA-192105|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|uniprotkb:P22059(identity)|ddbj/embl/genbank:BC011581(identity)|entrezgene/locuslink:5007(identity)|human orfeome collection:7234(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 3C|antagonist:OSW-1, OSW-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) ec50:60.0x10^-9(molar) 2014/03/06 2014/10/16 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:9LgzhfWQ0E/ECTTKA1OogQSyuAI9606 intact-crc:BBE69DE4EBC794C7|rigid:GE7KGqUZ3VL5zrJrIjiCDLg3SLk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:P22681 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364577|imex:IM-22301-372 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 intact-crc:C3AC8B9158C0AE21|rigid:U2IqJfCU3PZpk8LhZxV8h6A7dz8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P22695 uniprotkb:Q15773 intact:EBI-1051424|uniprotkb:Q9BQ05|uniprotkb:B3KSN4|ensembl:ENSP00000268379 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:qcr2_human(display_long)|uniprotkb:Ubiquinol-cytochrome-c reductase complex core protein 2(gene name synonym)|uniprotkb:Core protein II(gene name synonym)|uniprotkb:Complex III subunit 2(gene name synonym)|uniprotkb:UQCRC2(gene name)|psi-mi:UQCRC2(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364597|imex:IM-22301-373 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003357.2|ensembl:ENSG00000140740(gene)|ensembl:ENST00000268379(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006508"(proteolysis)|go:"GO:0009060"(aerobic respiration)|go:"GO:0042493"|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|mint:P22695|rcsb pdb:5XTE|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|uniprotkb:P22695(identity)|ddbj/embl/genbank:BC000484(identity)|human orfeome collection:3132(identity)|entrezgene/locuslink:7385(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:++DmwaVpqzRyxFl7mh62L4ku4P09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:16A99E2702935A9C|rigid:CE7i7xjQag6x5N+dzOB5dNoHVuk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P25098 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-3904795|uniprotkb:Q6GTT3|uniprotkb:B0ZBE1|uniprotkb:Q13837|ensembl:ENSP00000312262 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:arbk1_human(display_long)|uniprotkb:GRK2(gene name)|psi-mi:GRK2(display_short)|uniprotkb:ADRBK1(gene name synonym)|uniprotkb:BARK(gene name synonym)|uniprotkb:BARK1(gene name synonym)|uniprotkb:G-protein coupled receptor kinase 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364619|imex:IM-22301-374 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001610.2|dip:DIP-42429N|ensembl:ENSG00000173020(gene)|ensembl:ENST00000308595(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0003108"(negative regulation of the force of heart contraction by chemical signal)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004703"(G protein-coupled receptor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007217"(tachykinin receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019079"(viral genome replication)|go:"GO:0031623"(receptor internalization)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031755"(Edg-2 lysophosphatidic acid receptor binding)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0005737"(cytoplasm)|go:"GO:0045988"(negative regulation of striated muscle contraction)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0047696"(beta-adrenergic receptor kinase activity)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1901081"(negative regulation of relaxation of smooth muscle)|interpro:IPR000239(GPCR kinase)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036305|mint:P25098|rcsb pdb:1BAK|rcsb pdb:3CIK|rcsb pdb:3KRW|rcsb pdb:3KRX|rcsb pdb:3V5W|rcsb pdb:4MK0|rcsb pdb:4PNK|rcsb pdb:5HE1|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UUU|rcsb pdb:5UVC|rcsb pdb:5WG3|rcsb pdb:5WG4|rcsb pdb:5WG5|rcsb pdb:6C2Y|rcsb pdb:6U7C|rcsb pdb:7K7L|rcsb pdb:7K7Z|reactome:R-HSA-111933|reactome:R-HSA-416476|reactome:R-HSA-418555|reactome:R-HSA-5635838|reactome:R-HSA-8856825|go:"GO:0045202"(synapse)|uniprotkb:P25098(identity)|human orfeome collection:10135(identity)|entrezgene/locuslink:156(identity)|ddbj/embl/genbank:BC037963(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:iAd5kj9koCtmmVivrWfgN4y0YMc9606 intact-crc:86B00C0CC149894B|rigid:9AyxLDK4CqjWRdkY0WMqppyO8fc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25686 uniprotkb:P58340 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364639|imex:IM-22301-375 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N|uniprotkb:P25686(identity)|human orfeome collection:6133(identity)|ddbj/embl/genbank:BC011609(identity)|entrezgene/locuslink:3300(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:A334B0D1FCB65E4E|rigid:Zb29D5o8Mo5mtnpz6TUc27OckGw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25686 uniprotkb:Q15773 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364661|imex:IM-22301-376 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N|uniprotkb:P25686(identity)|human orfeome collection:6133(identity)|ddbj/embl/genbank:BC011609(identity)|entrezgene/locuslink:3300(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:F961BB3D9157F2E3|rigid:X/ccFQk4HhEuVgViOgAQyqLkauQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25686 uniprotkb:Q53FC7 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 intact:EBI-9356749 psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364683|imex:IM-22301-377 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N|uniprotkb:P25686(identity)|human orfeome collection:6133(identity)|ddbj/embl/genbank:BC011609(identity)|entrezgene/locuslink:3300(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:A054EEFC4313AFCD|rigid:k1TxzMvAEJgcPYvfTD5GID3+HWo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25686 uniprotkb:Q13200 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364705|imex:IM-22301-378 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N|uniprotkb:P25686(identity)|human orfeome collection:6133(identity)|ddbj/embl/genbank:BC011609(identity)|entrezgene/locuslink:3300(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:537BC322C49CAD28|rigid:E3K1NHG1/TcqkNa2E00fzWhJvIk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P25686 uniprotkb:Q96BE0 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 intact:EBI-9356686 psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364727|imex:IM-22301-379 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N|uniprotkb:P25686(identity)|human orfeome collection:6133(identity)|ddbj/embl/genbank:BC011609(identity)|entrezgene/locuslink:3300(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:E5B0F8AB17C7391F|rigid:R+cBYY7PKAyKqRC0LbREdMph+uA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P25705 intact:EBI-9356686 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:q96be0_human(display_long) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364749|imex:IM-22301-380 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613|uniprotkb:P25705(identity)|human orfeome collection:2986(identity)|ddbj/embl/genbank:BC011384(identity)|entrezgene/locuslink:498(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 intact-crc:487D9D18ED9D0BCC|rigid:hgzPPo0mBwb3CyYmmNDpoLiNUNU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30679 uniprotkb:P58340 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364779|imex:IM-22301-381 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:B769DE7F8049BE28|rigid:tHo/Y3K1+vnecIhfcs2EMJIEO0w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P30679 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364801|imex:IM-22301-382 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 intact-crc:6DA76DE79B619A64|rigid:eRHIPWA88D1B7eopEHMKEfoJdto false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P30679 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364822|imex:IM-22301-383 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 intact-crc:0ED6458FB9E8FCEC|rigid:Ls8qzoAH5w/E3NIEB1d9EfmDMm4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:P30679 intact:EBI-9357141 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 psi-mi:q9hav2_human(display_long) psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364844|imex:IM-22301-384 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 intact-crc:9B50487114A55EB0|rigid:Fl4aO+skdZ62G11QrseL6sAwhhY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30679 uniprotkb:Q13200 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364866|imex:IM-22301-385 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:35246FBB2B59F3BA|rigid:njJ8ool529locZWkDpg8sty6gQ0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30679 uniprotkb:Q3UJD6-1 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364888|imex:IM-22301-386 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:D4F30E8ED2D54BAF|rigid:6qjEnO32RFLmDvl9JWZR7o/yIzU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:P30679 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364909|imex:IM-22301-387 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 intact-crc:FD4F98936A66F5F3|rigid:HKK3uKWVCOKIgVzI5iHfhsnyNKc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30679 uniprotkb:Q9HB71 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364928|imex:IM-22301-388 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity)|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:3CD7D74E22D2760A|rigid:gzSTQ/BTfXA0ZfN5RhiAIFGPWS0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P30679 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9364771|uniprotkb:Q53XK2|uniprotkb:O75247|uniprotkb:E9KL40|uniprotkb:E9KL47|ensembl:ENSP00000262958 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:gna15_human(display_long)|uniprotkb:GNA15(gene name)|psi-mi:GNA15(display_short)|uniprotkb:Epididymis tissue protein Li 17E(gene name synonym)|uniprotkb:GNA16(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit alpha-16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364947|imex:IM-22301-389 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_002059.3|ensembl:ENSG00000060558(gene)|ensembl:ENST00000262958(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007207"(phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|uniprotkb:P30679(identity)|ddbj/embl/genbank:BC013585(identity)|human orfeome collection:3081(identity)|entrezgene/locuslink:2769(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:bcrcjBCgzQ0kNrf02VfqJhHhGLU9606 intact-crc:4EFDA42D1E8F4642|rigid:irUlAT/KingIHH19rwPVGC99VEA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:P30876 intact:EBI-9356778 intact:EBI-394712|uniprotkb:Q8IZ61|uniprotkb:A8K1A8|ensembl:ENSP00000312735|ensembl:ENSP00000370625 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:rpb2_human(display_long)|uniprotkb:POLR2B(gene name)|psi-mi:POLR2B(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit B(gene name synonym)|uniprotkb:RNA polymerase II subunit B2(gene name synonym)|uniprotkb:RNA polymerase II subunit 2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 140 kDa polypeptide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364969|imex:IM-22301-390 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_000929.1|refseq:NP_001290197.1|refseq:NP_001290198.1|ensembl:ENSG00000047315(gene)|ensembl:ENST00000314595(transcript)|ensembl:ENST00000381227(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:P30876|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32910N|uniprotkb:P30876(identity)|ddbj/embl/genbank:BC023503(identity)|entrezgene/locuslink:5431(identity)|human orfeome collection:12417(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:YhEjtfLk2QnbRPefOp8ZHX0ejak9606 intact-crc:E832683A10FC96BA|rigid:J7XnPptYoVSesogQEgtVMfAxNU0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30988-2 uniprotkb:Q15773 intact:EBI-9364994 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9364991|imex:IM-22301-391 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:AAEEDDEFE2CEFF50|rigid:7hqJo/7hclHweQBcwKIxibcr6kw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:P30988-2 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-9364994 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365017|imex:IM-22301-392 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 intact-crc:6846445D3401A42B|rigid:d+5DIUD4SWPaJ5i2Gop7UAJnXzk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P30988-2 uniprotkb:Q9Y266 intact:EBI-9364994 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365036|imex:IM-22301-393 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:11283FAADCC19555|rigid:CMj3ZAqlspQLEeAycONbUMXzpc0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P30988-2 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9364994 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365055|imex:IM-22301-394 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 intact-crc:4E548C6252568D70|rigid:YRmdeFr3Wt/Z2iUzewylwUQUksw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P30988-2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9364994 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365074|imex:IM-22301-395 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 intact-crc:939DA4A0035F539A|rigid:Gu+YljziswZ4VrQ6Ijafx/0zLyI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P30988-2 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9364994 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:p30988-2(display_long)|uniprotkb:CALCR(gene name)|psi-mi:CALCR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365095|imex:IM-22301-396 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) intact:EBI-2615663(isoform-parent)|uniprotkb:P30988-2(identity)|entrezgene/locuslink:799(identity)|human orfeome collection:13932(identity)|ddbj/embl/genbank:BC069611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:V0q51XFaOJIWf/YwUm5lirXh6Cc9606 intact-crc:0D243545B681F92E|rigid:YPsnOEZiAC1GeyJ79uk6L637+DI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:P33992 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365117|imex:IM-22301-397 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:EA0D3C66B39AC35F|rigid:LgmuSrnvzhua5gDm1CzeRhTtwPs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:P58340 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365136|imex:IM-22301-398 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:FDC559DAC9C3E94C|rigid:ruPJkaNldlkNjesQMERdjr8vjYg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P33992 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365158|imex:IM-22301-399 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:D9FBCC52587BDFF8|rigid:PCZ/yxBjHw4xNejHCtKtD1RyyV8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:Q03933 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365180|imex:IM-22301-400 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:F598FE4FCDDD1EAD|rigid:Mr2rYRJPOcm00SA0CnltppzYQKg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:P33992 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365199|imex:IM-22301-401 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:D52717DBCD52443F|rigid:s0ZTNzJA6Y6zuIZuR0+zLvFyGPk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:Q8IVD9 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365221|imex:IM-22301-402 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:2899F0624CB16208|rigid:NmJloqtyakndCervjExWBJb/UPI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:Q13200 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365240|imex:IM-22301-403 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:00348F78D2CBD3E1|rigid:Ez67qZeKgGk8+q0wAGeZ6kP1xO4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P33992 intact:EBI-9356686 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:q96be0_human(display_long) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365262|imex:IM-22301-404 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:EE4797238C2EA61A|rigid:CO98yBqrPP6folZgdbbjkV5yyI8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:Q9UNE7 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365284|imex:IM-22301-405 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:65EBCE754ADC220C|rigid:oPcJNWgH1iMS0JvucSvnp9X92/k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P33992 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365306|imex:IM-22301-406 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:DC756C75F6C2890C|rigid:fHV51XZz+HJtaDr2oLH4mxDXfwM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33992 uniprotkb:Q9BTE6-2 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365325|imex:IM-22301-407 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity)|human orfeome collection:19(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:7E55B34CF0AC8B80|rigid:lGP6fziRFkatk7tj3oOnN21kgsQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:P33993 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365347|imex:IM-22301-408 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:C223366F791688F9|rigid:nak50pJtgttfWC3JTFG9/beRNW8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33993 uniprotkb:P58340 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365366|imex:IM-22301-409 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:4A29B21C546D2A80|rigid:/tIaP4A5NC1rsSCRppRt3lP6fFY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P33993 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365388|imex:IM-22301-410 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:81DA185FEAE50AD8|rigid:dCct33dusa1edKTiRv7JBc54JFQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33993 uniprotkb:Q15773 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365409|imex:IM-22301-411 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:13103BA1D5035B14|rigid:3HmD6xFHMYOzE+RXQYD1pfYbxUE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:P33993 intact:EBI-9356749 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:q53fc7_human(display_long) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365431|imex:IM-22301-412 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity)|uniprotkb:P33993(identity)|human orfeome collection:6643(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:0FA213DD0B8972CB|rigid:LAxxQpLzUcGY1vbd3GeZgDMyYUA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P33993 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365453|imex:IM-22301-413 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:6B2F398EF79E11C5|rigid:1xUwTrt7RjidYEuB5zKt0/9NBWY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33993 uniprotkb:Q3UJD6-1 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365472|imex:IM-22301-414 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:0325E3A032397174|rigid:VUpAK7QBrl+GSbDi7pGYCE5zxXs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P33993 intact:EBI-9356686 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:q96be0_human(display_long) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365493|imex:IM-22301-415 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:4E0EE9F315AE8779|rigid:4KOGRZXvYysavq/afZgV8XhLX9k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:P33993 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365515|imex:IM-22301-416 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:DFE3474BFAD46032|rigid:kerpm7X+nycItm7cKtkCW8Ctqeo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33993 uniprotkb:Q9BTE6-2 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365534|imex:IM-22301-417 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|human orfeome collection:6643(identity)|entrezgene/locuslink:4176(identity)|ddbj/embl/genbank:BC013375(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:BC84E71BB6083BE5|rigid:2sjdA1YiewPOc7vZtczJqHhn5Jc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P34972 uniprotkb:Q13200 intact:EBI-2835940|uniprotkb:C6ES44|uniprotkb:Q6NSY0|uniprotkb:Q5JRH7|uniprotkb:Q6B0G7|uniprotkb:Q4VBK8|ensembl:ENSP00000363596 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:cnr2_human(display_long)|uniprotkb:CNR2(gene name)|psi-mi:CNR2(display_short)|uniprotkb:CX5(gene name synonym)|uniprotkb:CB2A(gene name synonym)|uniprotkb:CB2B(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365556|imex:IM-22301-418 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011538931.1|reactome:R-HSA-418594|refseq:NP_001832.1|ensembl:ENSG00000188822(gene)|ensembl:ENST00000374472(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030425"(dendrite)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001551(Cannabinoid receptor, type 2)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2KI9|rcsb pdb:5ZTY|rcsb pdb:6KPC|rcsb pdb:6KPF|rcsb pdb:6PT0|reactome:R-HSA-373076|refseq:XP_016855750.1|uniprotkb:P34972(identity)|entrezgene/locuslink:1269(identity)|human orfeome collection:14013(identity)|ddbj/embl/genbank:BC069722(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tOzrkRHM0nOinnvHIdURS9h1HVc9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:35554FD62D88031F|rigid:2+DM7HE0SQbXRSTUsPqRjCeXLE8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35251 uniprotkb:Q96BE0 intact:EBI-476616|uniprotkb:Q5XKF5|uniprotkb:Q6PKU0|uniprotkb:Q86V41|uniprotkb:Q86V46|ensembl:ENSP00000371321|uniprotkb:A8K6E7 intact:EBI-9356686 psi-mi:rfc1_human(display_long)|uniprotkb:Activator 1 subunit 1(gene name synonym)|uniprotkb:Replication factor C large subunit(gene name synonym)|uniprotkb:Replication factor C 140 kDa subunit(gene name synonym)|uniprotkb:Activator 1 140 kDa subunit(gene name synonym)|uniprotkb:Activator 1 large subunit(gene name synonym)|uniprotkb:DNA-binding protein PO-GA(gene name synonym)|uniprotkb:RFC1(gene name)|psi-mi:RFC1(display_short)|uniprotkb:RFC140(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365578|imex:IM-22301-419 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001191676.1|refseq:NP_002904.3|ensembl:ENSG00000035928(gene)|ensembl:ENST00000381897(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003689"(DNA clamp loader activity)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061860"(DNA clamp unloader activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090618"(DNA clamp unloading)|interpro:IPR001357(BRCT)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012178(DNA replication factor C, large subunit)|interpro:IPR013725(DNA replication factor RFC1, C-terminal)|interpro:IPR027417|interpro:IPR036420|mint:P35251|rcsb pdb:2EBU|rcsb pdb:2K6G|rcsb pdb:2K7F|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-69091|uniprotkb:P35251(identity)|ddbj/embl/genbank:BC035297(identity)|entrezgene/locuslink:5981(identity)|human orfeome collection:14176(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m4MUwhmpn0xCElyHLAw4FlIVyBs9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:AC6197D071A02F2D|rigid:11F5I++mhgz3VAHB9713CGwueFc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWX7 uniprotkb:P35998 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365600|imex:IM-22301-420 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N|uniprotkb:P35998(identity)|ddbj/embl/genbank:BC002589(identity)|human orfeome collection:7961(identity)|entrezgene/locuslink:5701(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:A47895469880196C|rigid:bH3qomTqFR4TsoHtyhkjPVWWVDg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P35998 intact:EBI-9356686 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:q96be0_human(display_long) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365622|imex:IM-22301-421 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N|uniprotkb:P35998(identity)|ddbj/embl/genbank:BC002589(identity)|human orfeome collection:7961(identity)|entrezgene/locuslink:5701(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:6C0C23D86391B81D|rigid:Ioo4u7SCEJSynbLiw8+fnKgKTaU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P35998 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365644|imex:IM-22301-422 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N|uniprotkb:P35998(identity)|ddbj/embl/genbank:BC002589(identity)|human orfeome collection:7961(identity)|entrezgene/locuslink:5701(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:57CF861441646B80|rigid:oYWHR3Mqv/KONjOUzVFvwABwG7E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35998 uniprotkb:Q53HB3 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 intact:EBI-9362707 psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:q53hb3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365666|imex:IM-22301-423 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N|uniprotkb:P35998(identity)|ddbj/embl/genbank:BC002589(identity)|human orfeome collection:7961(identity)|entrezgene/locuslink:5701(identity) interpro:IPR035244|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|uniprotkb:Q53HB3(identity)|ddbj/embl/genbank:BC000512(identity)|entrezgene/locuslink:5700(identity)|human orfeome collection:4018(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 rogid:Unfk3E8DIsBKU/b5AIjm4wDR26M9606 intact-crc:636373598F5721B8|rigid:CEQ6VFO2lASPUXS10U5QFDr6AS8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P38405-2 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9365691|ensembl:ENSP00000334051 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:p38405-2(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365688|imex:IM-22301-424 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000141404(gene)|ensembl:ENST00000334049(transcript)|intact:EBI-2512639(isoform-parent)|uniprotkb:P38405-2(identity)|entrezgene/locuslink:2774(identity)|human orfeome collection:10675(identity)|ddbj/embl/genbank:BC050021(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:vQCVPYOmAcbBJPoPVjLCdpCUs+I9606 intact-crc:5D554E9ED77ABCD1|rigid:/VpVuAgkHT02khgACoV26vQ42dk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P38405-2 intact:EBI-9356629 intact:EBI-9365691|ensembl:ENSP00000334051 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:p38405-2(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365714|imex:IM-22301-425 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000141404(gene)|ensembl:ENST00000334049(transcript)|intact:EBI-2512639(isoform-parent)|uniprotkb:P38405-2(identity)|entrezgene/locuslink:2774(identity)|human orfeome collection:10675(identity)|ddbj/embl/genbank:BC050021(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:vQCVPYOmAcbBJPoPVjLCdpCUs+I9606 intact-crc:2946EE88C8B00E59|rigid:c2BjusfnZX+BL3pwVd4K9oWn43Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P38405-2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9365691|ensembl:ENSP00000334051 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:p38405-2(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365736|imex:IM-22301-426 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000141404(gene)|ensembl:ENST00000334049(transcript)|intact:EBI-2512639(isoform-parent)|uniprotkb:P38405-2(identity)|entrezgene/locuslink:2774(identity)|human orfeome collection:10675(identity)|ddbj/embl/genbank:BC050021(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:vQCVPYOmAcbBJPoPVjLCdpCUs+I9606 intact-crc:CCB10A6C1EAEC7EA|rigid:KfgmNrZdYvbNEzp3Rn1Huq9Phws false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P38405-2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9365691|ensembl:ENSP00000334051 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:p38405-2(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365757|imex:IM-22301-427 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000141404(gene)|ensembl:ENST00000334049(transcript)|intact:EBI-2512639(isoform-parent)|uniprotkb:P38405-2(identity)|entrezgene/locuslink:2774(identity)|human orfeome collection:10675(identity)|ddbj/embl/genbank:BC050021(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:vQCVPYOmAcbBJPoPVjLCdpCUs+I9606 intact-crc:CCED91CC92C87E17|rigid:72OzUV2Jr22jzd4RAiSsoz8Ruls false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P38405-2 intact:EBI-9356686 intact:EBI-9365691|ensembl:ENSP00000334051 psi-mi:q96be0_human(display_long) psi-mi:p38405-2(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365779|imex:IM-22301-428 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000141404(gene)|ensembl:ENST00000334049(transcript)|intact:EBI-2512639(isoform-parent)|uniprotkb:P38405-2(identity)|entrezgene/locuslink:2774(identity)|human orfeome collection:10675(identity)|ddbj/embl/genbank:BC050021(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:vQCVPYOmAcbBJPoPVjLCdpCUs+I9606 intact-crc:42145D266284F898|rigid:M9/m0iE17XrxhLJ/ChFv6kgC9Ck false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P40337 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-301246|uniprotkb:Q13599|uniprotkb:B2RE45|uniprotkb:Q6PDA9|ensembl:ENSP00000256474 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:vhl_human(display_long)|uniprotkb:VHL(gene name)|psi-mi:VHL(display_short)|uniprotkb:pVHL(gene name synonym)|uniprotkb:Protein G7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365801|imex:IM-22301-429 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) rcsb pdb:6BVB|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:4W9I|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:4W9J|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:4W9K|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6SIS|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-1234176|reactome:R-HSA-3232142|rcsb pdb:4W9L|reactome:R-HSA-8951664|rcsb pdb:4WQO|reactome:R-HSA-9682706|reactome:R-HSA-9694686|reactome:R-HSA-9706019|reactome:R-HSA-983168|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|ensembl:ENSG00000134086(gene)|ensembl:ENST00000256474(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006508"(proteolysis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050821"(protein stabilization)|go:"GO:0061418"(regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002714(Tumour suppressor protein, von Hippel-Lindau disease)|interpro:IPR022772|interpro:IPR024048|interpro:IPR024053|interpro:IPR036208|interpro:IPR037139|interpro:IPR037140|mint:P40337|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|refseq:NP_000542.1|refseq:NP_937799.1|dip:DIP-32585N|uniprotkb:P40337(identity)|entrezgene/locuslink:7428(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:KaCKDTSj0xPG9YmfFsXIbkRt3A89606 intact-crc:E939E7451DDEF4A9|rigid:FgATFa0HcnnzaUhrPVQW3sSZakg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P43155 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365821|imex:IM-22301-430 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 intact-crc:B55F0519B1FCD3FB|rigid:kUVxmkppHszhB63P0KOZQCf9tBk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P43155 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365843|imex:IM-22301-431 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 intact-crc:CAADD4563F1D25B8|rigid:jhEJ4TgOuRD+VTNYR9k5y4r9FuU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P43155 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365865|imex:IM-22301-432 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 intact-crc:19697A30356BB91B|rigid:MFhDtJk1kRLEfljsIK7BvOGwME8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43155 uniprotkb:Q96BE0 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 intact:EBI-9356686 psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365884|imex:IM-22301-433 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:5312C1902554B3E8|rigid:S4z+t9P5YLHupWqg10TEltboaYM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43155 uniprotkb:Q9HB71 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365906|imex:IM-22301-434 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:0DF5192E25E713F1|rigid:TH1v9c0Owq4tOk1HwnIH8Ua60GE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43155 uniprotkb:Q9BTE6-2 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365925|imex:IM-22301-435 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:0739AF90DD42EE23|rigid:UdIL2jWoU2vVqaxTCLZZpwjdfek false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:P43155 intact:EBI-9356778 intact:EBI-2843568|uniprotkb:Q5T952|uniprotkb:Q9BW16|ensembl:ENSP00000315013 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:cacp_human(display_long)|uniprotkb:CRAT(gene name)|psi-mi:CRAT(display_short)|uniprotkb:CAT1(gene name synonym)|uniprotkb:Carnitine acetyltransferase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365947|imex:IM-22301-436 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:XP_005251765.1|ensembl:ENSG00000095321(gene)|ensembl:ENST00000318080(transcript)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0004092"(carnitine O-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0008458"(carnitine O-octanoyltransferase activity)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0046459"(short-chain fatty acid metabolic process)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR039551|interpro:IPR042231|rcsb pdb:1NM8|rcsb pdb:1S5O|reactome:R-HSA-389887|reactome:R-HSA-9033241|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|uniprotkb:P43155(identity)|entrezgene/locuslink:1384(identity)|ddbj/embl/genbank:BC000723(identity)|human orfeome collection:3461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:8RNAVz4LO74SbC/vjUy8iMVnTwM9606 intact-crc:FA92BA6546B81EFB|rigid:8gfRwZkYDGrldu1WjNXEcrwYASY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P43250-2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-6428342|ensembl:ENSP00000433511 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:p43250-2(display_long)|uniprotkb:GRK6(gene name)|psi-mi:GRK6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:GPRK6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365969|imex:IM-22301-437 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) intact:EBI-722747(isoform-parent)|uniprotkb:P43250-2(isoform-parent)|ensembl:ENSG00000198055(gene)|ensembl:ENST00000528793(transcript)|uniprotkb:P43250-2(identity)|human orfeome collection:7844(identity)|ddbj/embl/genbank:BC017272(identity)|entrezgene/locuslink:2870(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:uh6b8LR7Q9Oow6qWuRIEh5/j+7Y9606 intact-crc:21D38D4145BD6BF1|rigid:sS50zYutCZ+WVdUQz5AnxEw75gE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43250-2 uniprotkb:Q96BE0 intact:EBI-6428342|ensembl:ENSP00000433511 intact:EBI-9356686 psi-mi:p43250-2(display_long)|uniprotkb:GRK6(gene name)|psi-mi:GRK6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:GPRK6(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9365990|imex:IM-22301-438 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-722747(isoform-parent)|uniprotkb:P43250-2(isoform-parent)|ensembl:ENSG00000198055(gene)|ensembl:ENST00000528793(transcript)|uniprotkb:P43250-2(identity)|human orfeome collection:7844(identity)|ddbj/embl/genbank:BC017272(identity)|entrezgene/locuslink:2870(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uh6b8LR7Q9Oow6qWuRIEh5/j+7Y9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:02A9B342033D300C|rigid:A5nrvbix8sKJ2FayG8lZNDEUJ4s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43250-2 uniprotkb:P58340 intact:EBI-6428342|ensembl:ENSP00000433511 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:p43250-2(display_long)|uniprotkb:GRK6(gene name)|psi-mi:GRK6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:GPRK6(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366012|imex:IM-22301-439 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-722747(isoform-parent)|uniprotkb:P43250-2(isoform-parent)|ensembl:ENSG00000198055(gene)|ensembl:ENST00000528793(transcript)|uniprotkb:P43250-2(identity)|human orfeome collection:7844(identity)|ddbj/embl/genbank:BC017272(identity)|entrezgene/locuslink:2870(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uh6b8LR7Q9Oow6qWuRIEh5/j+7Y9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:C3165ACBBDFA1CD1|rigid:yR5QUimeISXsx08/9bNnvQ+oyvw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P43250-2 uniprotkb:Q15773 intact:EBI-6428342|ensembl:ENSP00000433511 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:p43250-2(display_long)|uniprotkb:GRK6(gene name)|psi-mi:GRK6(display_short)|uniprotkb:G protein-coupled receptor kinase GRK6(gene name synonym)|uniprotkb:GPRK6(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366034|imex:IM-22301-440 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-722747(isoform-parent)|uniprotkb:P43250-2(isoform-parent)|ensembl:ENSG00000198055(gene)|ensembl:ENST00000528793(transcript)|uniprotkb:P43250-2(identity)|human orfeome collection:7844(identity)|ddbj/embl/genbank:BC017272(identity)|entrezgene/locuslink:2870(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:uh6b8LR7Q9Oow6qWuRIEh5/j+7Y9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:C44DC452698D0CE1|rigid:J30tx5TG+8X2FDurNAwLjBUDXw4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P47871 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-3929902|uniprotkb:Q2M3M5|ensembl:ENSP00000383558|ensembl:ENSP00000500297 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:glr_human(display_long)|uniprotkb:GCGR(gene name)|psi-mi:GCGR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366056|imex:IM-22301-441 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0070873"(regulation of glycogen metabolic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0071377"(cellular response to glucagon stimulus)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003291(GPCR, family 2, glucagon receptor)|interpro:IPR017981|interpro:IPR036445|rcsb pdb:2A83|rcsb pdb:3CZF|rcsb pdb:4ERS|rcsb pdb:4L6R|rcsb pdb:4LF3|rcsb pdb:5EE7|rcsb pdb:5XEZ|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6WHC|rcsb pdb:6WPW|interpro:IPR017983|ensembl:ENSG00000215644(gene)|ensembl:ENSG00000288269(gene)|ensembl:ENST00000400723(transcript)|ensembl:ENST00000671794(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006887"(exocytosis)|refseq:NP_000151.1|refseq:XP_006722340.1|uniprotkb:P47871(identity)|entrezgene/locuslink:2642(identity)|human orfeome collection:71905(identity)|ddbj/embl/genbank:BC104854(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:eEM5H3Bw0XbI2cRVQWzkikaA8lo9606 intact-crc:C9C9DD98CB228014|rigid:+HNRcIxrL4Rgt8y4zHTrb/dq2CA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P47871 uniprotkb:Q13200 intact:EBI-3929902|uniprotkb:Q2M3M5|ensembl:ENSP00000383558|ensembl:ENSP00000500297 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:glr_human(display_long)|uniprotkb:GCGR(gene name)|psi-mi:GCGR(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366077|imex:IM-22301-442 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0070873"(regulation of glycogen metabolic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0071377"(cellular response to glucagon stimulus)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR003290(GPCR, family 2, glucagon receptor-like)|interpro:IPR003291(GPCR, family 2, glucagon receptor)|interpro:IPR017981|interpro:IPR036445|rcsb pdb:2A83|rcsb pdb:3CZF|rcsb pdb:4ERS|rcsb pdb:4L6R|rcsb pdb:4LF3|rcsb pdb:5EE7|rcsb pdb:5XEZ|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6WHC|rcsb pdb:6WPW|interpro:IPR017983|ensembl:ENSG00000215644(gene)|ensembl:ENSG00000288269(gene)|ensembl:ENST00000400723(transcript)|ensembl:ENST00000671794(transcript)|go:"GO:0004967"(glucagon receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006887"(exocytosis)|refseq:NP_000151.1|refseq:XP_006722340.1|uniprotkb:P47871(identity)|entrezgene/locuslink:2642(identity)|human orfeome collection:71905(identity)|ddbj/embl/genbank:BC104854(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eEM5H3Bw0XbI2cRVQWzkikaA8lo9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:A0B98F2F283C382D|rigid:VaV4HqRUaSJdYC9o4l8NqtyYxIU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49674 uniprotkb:Q13200 intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366099|imex:IM-22301-443 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|uniprotkb:P49674(identity)|human orfeome collection:4815(identity)|ddbj/embl/genbank:BC006490(identity)|entrezgene/locuslink:1454(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:evdzz03ba4MFWavN9xRae/Wxwio9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:9A32D2C1D9A5E4D5|rigid:kG+F/4qmwrUVPKAU6TaAhiyoX8s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P49674 intact:EBI-9356686 intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074 psi-mi:q96be0_human(display_long) psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366121|imex:IM-22301-444 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|uniprotkb:P49674(identity)|human orfeome collection:4815(identity)|ddbj/embl/genbank:BC006490(identity)|entrezgene/locuslink:1454(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:evdzz03ba4MFWavN9xRae/Wxwio9606 intact-crc:02CE1AAD2716C7F9|rigid:caFu5k59nRtLWMfOuPpiquBwaQg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P49674 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366143|imex:IM-22301-445 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|uniprotkb:P49674(identity)|human orfeome collection:4815(identity)|ddbj/embl/genbank:BC006490(identity)|entrezgene/locuslink:1454(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:evdzz03ba4MFWavN9xRae/Wxwio9606 intact-crc:6CB0A22FB1B59929|rigid:aFh4VzZWC/zkLeQqRL2dqWzYGpo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49758 uniprotkb:Q6PK50 intact:EBI-6426927|uniprotkb:O75577|uniprotkb:Q8TE18|uniprotkb:Q8TE22|uniprotkb:Q8TE13|uniprotkb:Q8TE14|uniprotkb:Q8TE17|uniprotkb:Q9Y245|uniprotkb:Q8TE21|uniprotkb:Q8TE20|uniprotkb:Q9UDT0|uniprotkb:Q8TE19|uniprotkb:Q9Y647|uniprotkb:Q8TE15|uniprotkb:Q8TE16|uniprotkb:Q9UDS8|uniprotkb:O75576|uniprotkb:C9JE95|uniprotkb:F8W7W5|uniprotkb:Q7Z4K3|uniprotkb:Q7Z4K4|uniprotkb:Q7Z4K5|uniprotkb:Q7Z4K6|ensembl:ENSP00000450936|ensembl:ENSP00000452331 intact:EBI-9356629 psi-mi:rgs6_human(display_long)|uniprotkb:RGS6(gene name)|psi-mi:RGS6(display_short)|uniprotkb:S914(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366165|imex:IM-22301-446 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877315.1|refseq:XP_016877318.1|refseq:XP_016877319.1|refseq:XP_016877321.1|refseq:XP_016877323.1|refseq:NP_001191345.1|refseq:NP_001191346.1|refseq:NP_001191347.1|refseq:NP_001191348.1|refseq:NP_001191349.1|refseq:NP_001191350.1|refseq:NP_001191351.1|refseq:NP_001191352.1|refseq:NP_001191353.1|refseq:NP_004287.3|ensembl:ENSG00000182732(gene)|ensembl:ENST00000553530(transcript)|ensembl:ENST00000555571(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR037956|interpro:IPR040759|rcsb pdb:2ES0|reactome:R-HSA-418594|reactome:R-HSA-6814122|uniprotkb:P49758(identity)|entrezgene/locuslink:9628(identity)|ddbj/embl/genbank:BC113572(identity)|human orfeome collection:53715(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ba3cti6K74k7bB3DKscWzG6SOGw9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:E48446328B49A3DE|rigid:l6LiBDmpiqj16ZYaoQ/apJCC5fY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49758 uniprotkb:Q13200 intact:EBI-6426927|uniprotkb:O75577|uniprotkb:Q8TE18|uniprotkb:Q8TE22|uniprotkb:Q8TE13|uniprotkb:Q8TE14|uniprotkb:Q8TE17|uniprotkb:Q9Y245|uniprotkb:Q8TE21|uniprotkb:Q8TE20|uniprotkb:Q9UDT0|uniprotkb:Q8TE19|uniprotkb:Q9Y647|uniprotkb:Q8TE15|uniprotkb:Q8TE16|uniprotkb:Q9UDS8|uniprotkb:O75576|uniprotkb:C9JE95|uniprotkb:F8W7W5|uniprotkb:Q7Z4K3|uniprotkb:Q7Z4K4|uniprotkb:Q7Z4K5|uniprotkb:Q7Z4K6|ensembl:ENSP00000450936|ensembl:ENSP00000452331 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:rgs6_human(display_long)|uniprotkb:RGS6(gene name)|psi-mi:RGS6(display_short)|uniprotkb:S914(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366187|imex:IM-22301-447 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877315.1|refseq:XP_016877318.1|refseq:XP_016877319.1|refseq:XP_016877321.1|refseq:XP_016877323.1|refseq:NP_001191345.1|refseq:NP_001191346.1|refseq:NP_001191347.1|refseq:NP_001191348.1|refseq:NP_001191349.1|refseq:NP_001191350.1|refseq:NP_001191351.1|refseq:NP_001191352.1|refseq:NP_001191353.1|refseq:NP_004287.3|ensembl:ENSG00000182732(gene)|ensembl:ENST00000553530(transcript)|ensembl:ENST00000555571(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR037956|interpro:IPR040759|rcsb pdb:2ES0|reactome:R-HSA-418594|reactome:R-HSA-6814122|uniprotkb:P49758(identity)|entrezgene/locuslink:9628(identity)|ddbj/embl/genbank:BC113572(identity)|human orfeome collection:53715(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ba3cti6K74k7bB3DKscWzG6SOGw9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:0DE9166BB42681B1|rigid:/9iPaYpJBHTz3DSrrfPIW57zHk0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49758 uniprotkb:Q9BTE6-2 intact:EBI-6426927|uniprotkb:O75577|uniprotkb:Q8TE18|uniprotkb:Q8TE22|uniprotkb:Q8TE13|uniprotkb:Q8TE14|uniprotkb:Q8TE17|uniprotkb:Q9Y245|uniprotkb:Q8TE21|uniprotkb:Q8TE20|uniprotkb:Q9UDT0|uniprotkb:Q8TE19|uniprotkb:Q9Y647|uniprotkb:Q8TE15|uniprotkb:Q8TE16|uniprotkb:Q9UDS8|uniprotkb:O75576|uniprotkb:C9JE95|uniprotkb:F8W7W5|uniprotkb:Q7Z4K3|uniprotkb:Q7Z4K4|uniprotkb:Q7Z4K5|uniprotkb:Q7Z4K6|ensembl:ENSP00000450936|ensembl:ENSP00000452331 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:rgs6_human(display_long)|uniprotkb:RGS6(gene name)|psi-mi:RGS6(display_short)|uniprotkb:S914(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366209|imex:IM-22301-448 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877315.1|refseq:XP_016877318.1|refseq:XP_016877319.1|refseq:XP_016877321.1|refseq:XP_016877323.1|refseq:NP_001191345.1|refseq:NP_001191346.1|refseq:NP_001191347.1|refseq:NP_001191348.1|refseq:NP_001191349.1|refseq:NP_001191350.1|refseq:NP_001191351.1|refseq:NP_001191352.1|refseq:NP_001191353.1|refseq:NP_004287.3|ensembl:ENSG00000182732(gene)|ensembl:ENST00000553530(transcript)|ensembl:ENST00000555571(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|interpro:IPR037956|interpro:IPR040759|rcsb pdb:2ES0|reactome:R-HSA-418594|reactome:R-HSA-6814122|uniprotkb:P49758(identity)|entrezgene/locuslink:9628(identity)|ddbj/embl/genbank:BC113572(identity)|human orfeome collection:53715(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ba3cti6K74k7bB3DKscWzG6SOGw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:18DCA40BEF3A57DD|rigid:TBa2GEWXwKHi8hof5mSGpv8yMZw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P50416 uniprotkb:Q9HB71 intact:EBI-2817330|uniprotkb:Q9BWK0|uniprotkb:Q8TCU0|ensembl:ENSP00000265641|ensembl:ENSP00000446108 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:cpt1a_human(display_long)|uniprotkb:CPT1A(gene name)|psi-mi:CPT1A(display_short)|uniprotkb:CPT1(gene name synonym)|uniprotkb:Carnitine O-palmitoyltransferase I, liver isoform(gene name synonym)|uniprotkb:Carnitine palmitoyltransferase 1A(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366231|imex:IM-22301-449 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001027017.1|refseq:NP_001867.2|refseq:XP_016872709.1|ensembl:ENSG00000110090(gene)|ensembl:ENST00000265641(transcript)|ensembl:ENST00000539743(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004095"(carnitine O-palmitoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006853"(carnitine shuttle)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042755"(eating behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0043279"(response to alkaloid)|go:"GO:0045471"(response to ethanol)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0097421"(liver regeneration)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990698"(palmitoleoyltransferase activity)|interpro:IPR000542(Acyltransferase ChoActase/COT/CPT)|interpro:IPR023213|interpro:IPR032476|interpro:IPR039551|interpro:IPR042231|mint:P50416|rcsb pdb:2LE3|reactome:R-HSA-1368082|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-5362517|uniprotkb:P50416(identity)|ddbj/embl/genbank:BC000185(identity)|entrezgene/locuslink:1374(identity)|human orfeome collection:3321(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fmB4d9VHyWPyV0uTf00NkOr/fM49606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:B81447E5B964B9F5|rigid:suH/xuN7zayGn8Hn5qOz3bFLirE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:P50750 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366250|imex:IM-22301-450 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:45E5CB9ABB77864B|rigid:+nINqzg/qhT1Fx/LzKH7hFCtIlc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P50750 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366269|imex:IM-22301-451 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:93E248A8F664158B|rigid:JMS/fEr08vz7PRLHn9KHfMw/Ffc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P50750 intact:EBI-9356629 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366290|imex:IM-22301-452 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:CABA5804F82C41F8|rigid:oKQO53C6TvqKMk0nuRELQ/XwlAI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P50750 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366312|imex:IM-22301-453 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:1A8BF29CAA233593|rigid:3+UR9CyBwNslje5NbHGtgdf1XLQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:P50750 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366334|imex:IM-22301-454 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:C9C9C46F08C3CB78|rigid:E5e+KR8eDIQTfGqveC97Vq4uEE8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P50750 intact:EBI-9356686 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:q96be0_human(display_long) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366355|imex:IM-22301-455 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:F69DB18065B02F0A|rigid:jiFslDmkeBOJFtF39vj4HRkt2Lw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:P50750 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366377|imex:IM-22301-456 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:6E4381EBF2A05020|rigid:bcfCQoA1gCWwD8P4uSh5h1jx/GY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P50750 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366398|imex:IM-22301-457 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|entrezgene/locuslink:1025(identity)|ddbj/embl/genbank:BC001968(identity)|human orfeome collection:2736(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:735F369B4D54016C|rigid:xRFty3OrhSKVdi8RnGdtORgA3ms false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:P58340 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366418|imex:IM-22301-458 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:B3582C5C001C2ABE|rigid:2wHrG9XA+Uu89kJ1aTzJOmtP4LU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P51788 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366440|imex:IM-22301-459 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 intact-crc:4492C3E86ACC31F5|rigid:OrW5RKcrqT10A1Fz3VmlQYkCjiQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:P51788 intact:EBI-9356749 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 psi-mi:q53fc7_human(display_long) psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366461|imex:IM-22301-460 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 intact-crc:9ABEC09F0889D701|rigid:mtPGP2bBxjey0xnrtPxE8k+k0/0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:O95816 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366483|imex:IM-22301-461 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:3BEB1C92B003342B|rigid:T89/gd1KUMTJ+phKMdqWnXe9oTM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:Q8IVD9 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366505|imex:IM-22301-462 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:34C95A69748EF6CD|rigid:dZCui+DtAfafr0CsGoPwsFS4Rns false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:P51788 intact:EBI-9357028 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 psi-mi:b4dyc6_human(display_long) psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366524|imex:IM-22301-463 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 intact-crc:C231AA033CC8B63D|rigid:tztz7pP4ZRv8i4loJ/6e2ltEvt8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:Q13200 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366544|imex:IM-22301-464 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:9F3A4499345731B1|rigid:vQGqDjWRMhVLPhSx6kHpoQd6fBw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:O43765 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366566|imex:IM-22301-465 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:8312842C67B30C2B|rigid:wJ/8E1EBT8kX+XLOIKGMBwnrORM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:Q3UJD6-1 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366588|imex:IM-22301-466 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:E0D449F488AAD67F|rigid:pdooM4h5iYRYR7TyakyGqnAW/s0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P51788 uniprotkb:Q96BE0 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 intact:EBI-9356686 psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366609|imex:IM-22301-467 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:4AC5D447F5C61F66|rigid:0qB8Kaui93g1npylHOdNNy2nRbc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:P51788 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366631|imex:IM-22301-468 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 intact-crc:1FF4077A8C113B06|rigid:BompWlNc16FQyKK0zSRWF13YI1c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P51788 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-5564233|uniprotkb:O14864|uniprotkb:Q6IPA9|uniprotkb:Q8WU13|uniprotkb:B4DQT9|uniprotkb:B4DZ58|uniprotkb:E9PBD9|uniprotkb:E9PCD2|ensembl:ENSP00000265593 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:clcn2_human(display_long)|uniprotkb:CLCN2(gene name)|psi-mi:CLCN2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366653|imex:IM-22301-469 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001164558.1|refseq:NP_004357.3|refseq:NP_001164559.1|refseq:NP_001164560.1|ensembl:ENSG00000114859(gene)|ensembl:ENST00000265593(transcript)|go:"GO:0005247"(voltage-gated chloride channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0032347"(regulation of aldosterone biosynthetic process)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060689"(cell differentiation involved in salivary gland development)|interpro:IPR001807(Chloride channel, voltage gated)|interpro:IPR002244(Chloride channel CLC-2)|interpro:IPR014743(Chloride channel, core)|reactome:R-HSA-2672351|go:"GO:0005887"(integral component of plasma membrane)|uniprotkb:P51788(identity)|entrezgene/locuslink:1181(identity)|human orfeome collection:9183(identity)|ddbj/embl/genbank:BC021578(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:zrp0qNDS5hX34TNRKucNockPsHw9606 intact-crc:785C02D6ABE3B8F2|rigid:C6pudKg9S0vFN6lod0CACDl+vVQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53618 uniprotkb:Q96RS6 intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366675|imex:IM-22301-470 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N|uniprotkb:P53618(identity)|human orfeome collection:1909(identity)|entrezgene/locuslink:1315(identity)|ddbj/embl/genbank:BC037280(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:48AA32A62A24FB10|rigid:/mDenrs2J+wFohCs3cqsEjHnEEo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:P54652 intact:EBI-9356749 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:q53fc7_human(display_long) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366694|imex:IM-22301-471 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:15F2C82E37FE7560|rigid:7yG15NoI3llVvca1h1sPAidyWRM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:P54652 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366716|imex:IM-22301-472 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:B771D508D037A714|rigid:OTV9DGQK0cNkabZDLSSyJ3j4WqA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:O95429 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366735|imex:IM-22301-473 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:A05A3EB5335DCF60|rigid:fFPmKeONrQydvrNuf/53YidBggA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q8IWX7 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366757|imex:IM-22301-474 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 intact-crc:0A2BCF86E0DF62C1|rigid:KwuGkl1n5CKPaF1Y1Hsj42Hv7a8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:P54652 intact:EBI-9357141 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:q9hav2_human(display_long) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366779|imex:IM-22301-475 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:9615A59D1E75FB36|rigid:/XraMMG1mNjjzY3tacEem6pEpuo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q13200 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366801|imex:IM-22301-476 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:DD18C476D9E218D9|rigid:Zr24Y0XAt1b9gT/PGVhVICvM0fs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q96BE0 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-9356686 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366823|imex:IM-22301-477 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:5F36397B56932A62|rigid:DC87UnG6mTYQi/OooS+KW8ZJ99A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92598 uniprotkb:P54652 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366845|imex:IM-22301-478 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453|uniprotkb:Q92598(identity)|ddbj/embl/genbank:BC037553(identity)|entrezgene/locuslink:10808(identity)|human orfeome collection:9615(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:A0BC77E0F91670F7|rigid:PMi1eswEdyyHI/csTdT3rPk3wL4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q9UIM3 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366867|imex:IM-22301-479 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:6271A97328D08754|rigid:wdieLP6LwHjVidUJKcMpfJYqrX8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:P54652 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366886|imex:IM-22301-480 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:FAC5CB6B73BB4977|rigid:1Pv5O98zbGCqeTr+EWVACGsC77Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q9BTE6-2 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366905|imex:IM-22301-481 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:E35A7E428119AFAE|rigid:vn3HMGsFkYMK4O85+w3/JkKg3q4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54652 uniprotkb:Q99614 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366927|imex:IM-22301-482 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|human orfeome collection:2170(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:AA601289E60F5F05|rigid:ojDdKgPq9S20tYgg5PrKC9qzDis false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P56192 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366946|imex:IM-22301-483 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N|uniprotkb:P56192(identity)|human orfeome collection:4697(identity)|entrezgene/locuslink:4141(identity)|ddbj/embl/genbank:BC002384(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 intact-crc:7ABB44690BDC4353|rigid:cHnEcJvu743mJEbr2mMw/s+sYaM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:P56192 intact:EBI-9356778 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366967|imex:IM-22301-484 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N|uniprotkb:P56192(identity)|human orfeome collection:4697(identity)|entrezgene/locuslink:4141(identity)|ddbj/embl/genbank:BC002384(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 intact-crc:B5BE96A3C52BF927|rigid:rFyoTyhZP0x2KpTNh3+L5Em9Sl8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P58340 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9366989|imex:IM-22301-485 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:92C65CB55E28DCA6|rigid:QmLGoXiEizP1aNmYiPL+V4v452k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P58340 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367011|imex:IM-22301-486 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:7215D0DABA7B1BB3|rigid:t7IlS5q0YTytdbWGL++fduAPdBg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q8IVD9 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367033|imex:IM-22301-487 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:F8E3BC8D2EED7614|rigid:dECVmlur9QAXP1QCTHmWozlH85M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q13200 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367052|imex:IM-22301-488 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:460C44AE2E74B168|rigid:Ui0Aw4zsmCUI7wXj56kUljl47zo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q96BE0 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9356686 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367074|imex:IM-22301-489 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:B1D4A72B0BA31E18|rigid:B3MGZaxAvpZqEPnbiyE/NuUQcQk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:P58340 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367096|imex:IM-22301-490 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:FC7E066841E0E825|rigid:XnG9GTSN0HNcRMRBYZfHKuihccA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9BTE6-2 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367115|imex:IM-22301-491 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:2C8D8FED847C5DCF|rigid:Ee6L3MNIApp1KIqnFEFQ3zxMTtg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q13451 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367137|imex:IM-22301-492 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:0014EE9CCB226EDC|rigid:gZwTdquklC59Yyzuo21suaHg2pg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:P58340 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367156|imex:IM-22301-493 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:5E64FC634742EE62|rigid:GVLRVdX1aS6RPFHRsXkUrPsWvFY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P59046 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367178|imex:IM-22301-494 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:BD9FFD0EC0AAF64C|rigid:dn15Wa7dKC8WKSSpKM4TMdcXgZY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q15773 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367199|imex:IM-22301-495 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:AA17A1F95E6E57C5|rigid:BRmxz2fhfmVmQalJA6b8IKkzccA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P59046 intact:EBI-9356629 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367221|imex:IM-22301-496 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:949834520CE1AEC4|rigid:UBECfzTuNf65GDlKzExaoYNXEik false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q53FC7 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-9356749 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367243|imex:IM-22301-497 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:68CFAA2C59E73898|rigid:cMg6/MGA3aL9AnQrnYfnyR20xPU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q03933 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367265|imex:IM-22301-498 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:FFE58AA9656D85B0|rigid:J9KUXpPPZNdIj4XxngipHS3rdoQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:P59046 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367284|imex:IM-22301-499 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:605B6D5211E2820D|rigid:eeGSCJCz6agjNVdYxD3L8YAd0kI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:B4DYC6 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-9357028 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367303|imex:IM-22301-500 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:0A5EF63112334673|rigid:gL7ZmTypDMw9TMcTPKl+EdK9duc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q3UJD6-1 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367367|imex:IM-22301-503 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:BE353F07099F406C|rigid:UXZ4kxuz6Kfr6JBnhhcprS+vxpY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:P59046 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367345|imex:IM-22301-502 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:CFDE815651390C74|rigid:PH5Wnj/Y+AqvMpoFs1si4TOmn/o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P59046 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367323|imex:IM-22301-501 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:113D4C3EDFCC74D7|rigid:rNL32bXiKcupXfrwfGnWEqBL7Dg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q96BE0 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-9356686 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367388|imex:IM-22301-504 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:6F828AEBD9709E09|rigid:5kV5oSXrrHFr3rKf5oZgJ5oyuQs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q9UIM3 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367450|imex:IM-22301-507 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:C5DA38C0E04B0EEA|rigid:Nmm4kcajTcuMyAG6WHi9zyUuxsA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:P59046 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367431|imex:IM-22301-506 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:CD6618D08CE7A231|rigid:Q2VNoZIFB6s6LRshIGQtbj+mj80 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:P59046 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367410|imex:IM-22301-505 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:998B1E65544EAC42|rigid:FI1PffQF68d/Tyf9bHAP5DHN6Y8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q9BPW0 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-9356778 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367552|imex:IM-22301-512 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:353713F19BA2404B|rigid:c8NReN3jB0gUky9EAFOeWBbL/8k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:P59046 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367530|imex:IM-22301-511 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:8A75E33AB9E7CDC3|rigid:anIhrWNDl9MaEyE3nF8sa3u4iTo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q9HB71 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367511|imex:IM-22301-510 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:4404BAED23B7A244|rigid:dt9kOD9k//sT2e3699uM17xbGJE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:P59046 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367489|imex:IM-22301-509 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 intact-crc:619075ED6FFB9A35|rigid:KucSaDo7ptsG/Q1BKPos8tSduPs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q16543 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367469|imex:IM-22301-508 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:4184F5347CF262E5|rigid:oXAvphWdDZ1uPe95eHA1w/cgHOE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:P62873 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367615|imex:IM-22301-515 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 intact-crc:E3B318B38C38835D|rigid:eCXMTZgANbd2af0jb7Jj10z2ZhI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P62873 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367593|imex:IM-22301-514 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 intact-crc:A8DDBC4904FE8983|rigid:pc1laOWnW63qIVj6/rERZFciJO8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P59046 uniprotkb:Q99614 intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367574|imex:IM-22301-513 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1|uniprotkb:P59046(identity)|entrezgene/locuslink:91662(identity)|ddbj/embl/genbank:BC028069(identity)|human orfeome collection:9461(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:19E14FFE8DED1B7F|rigid:cvR7mcA5W9pCrPXIXVs3o5zrDZk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q96BE0 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-9356686 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367700|imex:IM-22301-519 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:BB397DBFB2F2A4E5|rigid:BOXnCvUavIsZnDC0gGgaSLFjkMk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q13200 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367678|imex:IM-22301-518 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:9D0F6DC2EC7BB8B8|rigid:eo9cD0jEZpHLT+egYxSVYs3F4ck false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q8IVD9 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367659|imex:IM-22301-517 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:4225B05F352CCE3B|rigid:ENieJh6O7knqhED5OOU/p2RXmcs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q53FC7 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-9356749 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367637|imex:IM-22301-516 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:213CAE0BC26D3BB5|rigid:sbxNQcPX4/sJODDdkRFwadwut5w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:P31948 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367722|imex:IM-22301-520 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:D5BBFBA9504916B1|rigid:CDziRqyk42uPuCW83NcFvJLtuPA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P78395 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367782|imex:IM-22301-523 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 intact-crc:483241540C742A13|rigid:iOFXOf04bjemWlqGJ1K4dSeIJqw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q9BTE6-2 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367760|imex:IM-22301-522 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:030FE7DD3F914253|rigid:O8524UrwoKxy6gHEXIyH7mcVFX4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62873 uniprotkb:Q99471 intact:EBI-357130|ensembl:ENSP00000367872|ensembl:ENSP00000481878|uniprotkb:P04901|uniprotkb:P04697|uniprotkb:B1AJZ7|uniprotkb:Q1RMY8 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:gbb1_human(display_long)|uniprotkb:GNB1(gene name)|psi-mi:GNB1(display_short)|uniprotkb:Transducin beta chain 1(gene name synonym) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367741|imex:IM-22301-521 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62873|rcsb pdb:4KFM|rcsb pdb:4PNK|rcsb pdb:5HE0|rcsb pdb:5HE1|rcsb pdb:5HE2|rcsb pdb:5HE3|rcsb pdb:5UKK|rcsb pdb:5UKL|rcsb pdb:5UKM|rcsb pdb:5UZ7|rcsb pdb:6B3J|rcsb pdb:6CRK|rcsb pdb:6D9H|rcsb pdb:6DDE|rcsb pdb:6DDF|rcsb pdb:6E3Y|rcsb pdb:6EG8|rcsb pdb:6G79|rcsb pdb:6GDG|rcsb pdb:6KPF|rcsb pdb:6KPG|go:"GO:1903561"(extracellular vesicle)|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6LI3|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6M1H|rcsb pdb:6M1I|rcsb pdb:6M8S|rcsb pdb:6N4B|rcsb pdb:6NI3|rcsb pdb:6NIY|rcsb pdb:6OIJ|rcsb pdb:6OIK|rcsb pdb:6OMM|rcsb pdb:6ORV|rcsb pdb:6OS9|rcsb pdb:6OSA|rcsb pdb:6OT0|rcsb pdb:6P9X|rcsb pdb:6P9Y|rcsb pdb:6PB0|rcsb pdb:6PB1|rcsb pdb:6PT0|rcsb pdb:6UUN|rcsb pdb:6UUS|rcsb pdb:6UVA|rcsb pdb:6VCB|rcsb pdb:6VMS|rcsb pdb:6VN7|rcsb pdb:6WHA|rcsb pdb:6WHC|rcsb pdb:6WI9|rcsb pdb:6WPW|rcsb pdb:6WZG|rcsb pdb:6X18|rcsb pdb:6X19|rcsb pdb:6X1A|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|rcsb pdb:6XOX|rcsb pdb:7AUE|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7C2E|rcsb pdb:7CFM|rcsb pdb:7CFN|rcsb pdb:7CKW|rcsb pdb:7CKX|rcsb pdb:7CKY|rcsb pdb:7CKZ|rcsb pdb:7CMU|rcsb pdb:7CMV|rcsb pdb:7CRH|rcsb pdb:7CX2|rcsb pdb:7CX4|rcsb pdb:7D76|rcsb pdb:7D77|rcsb pdb:7D7M|rcsb pdb:7DFL|rcsb pdb:7E2X|rcsb pdb:7E2Y|rcsb pdb:7E2Z|rcsb pdb:7E32|rcsb pdb:7E33|rcsb pdb:7E9G|rcsb pdb:7E9H|rcsb pdb:7CX3|rcsb pdb:7EB2|rcsb pdb:7JOZ|rcsb pdb:7JV5|rcsb pdb:7JVP|rcsb pdb:7JVQ|rcsb pdb:7JVR|rcsb pdb:7K7L|rcsb pdb:7K7Z|rcsb pdb:7KH0|rcsb pdb:7L0P|rcsb pdb:7L0Q|rcsb pdb:7L0R|rcsb pdb:7L0S|rcsb pdb:7L1U|rcsb pdb:7L1V|rcsb pdb:7LCI|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-2485179|reactome:R-HSA-2514859|reactome:R-HSA-381676|reactome:R-HSA-381753|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|ensembl:ENST00000610897(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010659"(cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030507"(spectrin binding)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0047391"(alkylglycerophosphoethanolamine phosphodiesterase activity)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051020"(GTPase binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071870"(cellular response to catecholamine stimulus)|go:"GO:0097381"(photoreceptor disc membrane)|ensembl:ENSG00000078369(gene)|ensembl:ENST00000378609(transcript)|refseq:NP_001269467.1|refseq:NP_001269468.1|dip:DIP-599N|refseq:NP_002065.1|refseq:XP_016856548.1|refseq:XP_016856549.1|refseq:XP_016856550.1|uniprotkb:P62873(identity)|human orfeome collection:2786(identity)|ddbj/embl/genbank:BC004186(identity)|entrezgene/locuslink:2782(identity) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zP/G70MXiSQpzbyyWFTWrJFQENk9606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:51C0AA1FA226A8E3|rigid:vhoOpvDk296Su9fRZWA2rkx7/sI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78395 uniprotkb:Q6PK50 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 intact:EBI-9356629 psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367803|imex:IM-22301-524 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:1EBC607ACE4DE50F|rigid:bD4rSqwilXZPB7FqXoLFExIePtA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78395 uniprotkb:B4DYC6 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 intact:EBI-9357028 psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367866|imex:IM-22301-527 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:67D693930151E6F4|rigid:qb1O/A2EfrfTyyQsoC+oJEhK9bM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78395 uniprotkb:Q8IVD9 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367847|imex:IM-22301-526 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:FDCECA0C35003D7D|rigid:ssGynsELc0L8sEqt8vFIf2sjktE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:P78395 intact:EBI-9357141 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 psi-mi:q9hav2_human(display_long) psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367825|imex:IM-22301-525 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 intact-crc:856660EB3603D5CF|rigid:Ov5pOK+GArSEkeGOG0x7+z9Poh4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78395 uniprotkb:Q9BPW0 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 intact:EBI-9356778 psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367952|imex:IM-22301-531 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:ACE56A7642C966AB|rigid:vjSaj5aTmNBZ1oF4xet5zx20Z7o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78395 uniprotkb:Q9BTE6-2 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367930|imex:IM-22301-530 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:44E12DA2E8E38232|rigid:/tPBJnIaDJdrlS5HQtacAeWqai0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:P78395 intact:EBI-9356686 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 psi-mi:q96be0_human(display_long) psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367908|imex:IM-22301-529 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 intact-crc:6A2CA5EBC45BFD5C|rigid:4uYRRZFYam3ISO+Adstuu1g1lEQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P78395 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-348325|ensembl:ENSP00000381726|ensembl:ENSP00000381728|ensembl:ENSP00000384343|ensembl:ENSP00000385198|ensembl:ENSP00000445097|ensembl:ENSP00000445675|ensembl:ENSP00000484066|ensembl:ENSP00000486330|ensembl:ENSP00000486485|uniprotkb:O43481|uniprotkb:Q8IXN8|uniprotkb:B2R6Y7 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:prame_human(display_long)|uniprotkb:PRAME(gene name)|psi-mi:PRAME(display_short)|uniprotkb:MAPE(gene name synonym)|uniprotkb:Preferentially expressed antigen of melanoma(gene name synonym)|uniprotkb:OIP4(gene name synonym)|uniprotkb:Opa-interacting protein 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367886|imex:IM-22301-528 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001278644.1|refseq:NP_001278645.1|refseq:NP_001278646.1|refseq:NP_001278648.1|ensembl:ENSG00000185686(gene)|ensembl:ENSG00000275013(gene)|interpro:IPR032675|interpro:IPR026271|ensembl:ENST00000398743(transcript)|ensembl:ENST00000402697(transcript)|ensembl:ENST00000405655(transcript)|ensembl:ENST00000539862(transcript)|ensembl:ENST00000543184(transcript)|ensembl:ENST00000617728(transcript)|ensembl:ENST00000626503(transcript)|ensembl:ENST00000628830(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|ensembl:ENST00000398741(transcript)|refseq:NP_006106.1|refseq:NP_996836.1|refseq:NP_996837.1|refseq:NP_996838.1|refseq:NP_996839.1|refseq:NP_001305056.1|refseq:NP_001305055.1|uniprotkb:P78395(identity)|ddbj/embl/genbank:BC014074(identity)|entrezgene/locuslink:23532(identity)|human orfeome collection:7087(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:VdJSwUPADlQ09QZ6P/x7jEc3fRw9606 intact-crc:E66034A2F7543A1C|rigid:pr2DT3XX76P/eoq8MalxWvG6O5I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q02790 intact:EBI-9356629 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368059|imex:IM-22301-536 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|human orfeome collection:3733(identity)|ddbj/embl/genbank:BC001786(identity)|entrezgene/locuslink:2288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:65442A1B8E0B82B2|rigid:u8jgqeDmDte/CDbWtauXjT7yQPc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00597 uniprotkb:Q6PK50 intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454 intact:EBI-9356629 psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367994|imex:IM-22301-533 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N|uniprotkb:Q00597(identity)|entrezgene/locuslink:2176(identity)|human orfeome collection:7699(identity)|ddbj/embl/genbank:BC015748(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:F97D461D3EC00DCF|rigid:kHgbOvKsHissBbgoKrvGmlj1FLg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q00597 intact:EBI-9356686 intact:EBI-81625|uniprotkb:B1ALR8|ensembl:ENSP00000289081|ensembl:ENSP00000364454 psi-mi:q96be0_human(display_long) psi-mi:fancc_human(display_long)|uniprotkb:FANCC(gene name)|psi-mi:FANCC(display_short)|uniprotkb:FAC(gene name synonym)|uniprotkb:FACC(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368016|imex:IM-22301-534 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_000127.2|ensembl:ENST00000289081(transcript)|ensembl:ENST00000375305(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007281"(germ cell development)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR000686(Fanconi anaemia group C protein)|mint:Q00597|ensembl:ENSG00000158169(gene)|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-6796648|refseq:XP_011516667.1|refseq:NP_001230672.1|dip:DIP-32846N|uniprotkb:Q00597(identity)|entrezgene/locuslink:2176(identity)|human orfeome collection:7699(identity)|ddbj/embl/genbank:BC015748(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:gmacmiqQzb3w7pzyVgjbcSuXAjM9606 intact-crc:C55AAF99A35C633D|rigid:d0JHErpb9TdXvohosNTEbXi8L5Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q02790 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368038|imex:IM-22301-535 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|human orfeome collection:3733(identity)|ddbj/embl/genbank:BC001786(identity)|entrezgene/locuslink:2288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:3804C8B8BEF70B01|rigid:a21vEIQQHnOv2IyD0TUewNnZUZQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q00534 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-295663|uniprotkb:A4D1G0|ensembl:ENSP00000265734|ensembl:ENSP00000397087 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cdk6_human(display_long)|uniprotkb:CDK6(gene name)|psi-mi:CDK6(display_short)|uniprotkb:Serine/threonine-protein kinase PLSTIRE(gene name synonym)|uniprotkb:Cell division protein kinase 6(gene name synonym)|uniprotkb:CDKN6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9367974|imex:IM-22301-532 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001138778.1|refseq:NP_001250.1|refseq:XP_006715898.1|dip:DIP-687N|ensembl:ENSG00000105810(gene)|ensembl:ENST00000265734(transcript)|ensembl:ENST00000424848(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009615"(response to virus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0016592"(mediator complex)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030332"(cyclin binding)|go:"GO:0042063"(gliogenesis)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048699"(generation of neurons)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028788|mint:Q00534|rcsb pdb:1BI7|rcsb pdb:1BI8|rcsb pdb:1BLX|rcsb pdb:1G3N|rcsb pdb:1JOW|rcsb pdb:1XO2|rcsb pdb:2EUF|rcsb pdb:2F2C|rcsb pdb:3NUP|rcsb pdb:3NUX|rcsb pdb:4AUA|rcsb pdb:4EZ5|rcsb pdb:4TTH|rcsb pdb:5L2I|rcsb pdb:5L2S|rcsb pdb:5L2T|rcsb pdb:6OQL|rcsb pdb:6OQO|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8934593|reactome:R-HSA-9630794|reactome:R-HSA-9632700|reactome:R-HSA-9661069|uniprotkb:Q00534(identity)|ddbj/embl/genbank:BC052264(identity)|human orfeome collection:13668(identity)|entrezgene/locuslink:1021(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:IlAJCZ9bvB5RaBdS1rlPnqDL9xg9606 intact-crc:85109A36BEC96ED2|rigid:K9Z29lFaaftp7gN8Pdr+QGYHTQs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q02790 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368120|imex:IM-22301-539 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|human orfeome collection:3733(identity)|ddbj/embl/genbank:BC001786(identity)|entrezgene/locuslink:2288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:A194DB72AC5E6A1C|rigid:UTa3nqmbbXhxgxxMLB5HUkQk9E4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02790 uniprotkb:B4DYC6 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-9357028 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368100|imex:IM-22301-538 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|human orfeome collection:3733(identity)|ddbj/embl/genbank:BC001786(identity)|entrezgene/locuslink:2288(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:5EB25A28767725C4|rigid:qSxbJeKts20Y5hsFhI0E+rP/IfI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q02790 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368081|imex:IM-22301-537 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|human orfeome collection:3733(identity)|ddbj/embl/genbank:BC001786(identity)|entrezgene/locuslink:2288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:93E1FBE2B6281860|rigid:l4DCuKT5z7nlvwDHmH1+/+lTIEg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05C05 uniprotkb:Q15773 intact:EBI-9368143 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368140|imex:IM-22301-540 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:248E716EF0C4523A|rigid:gBeQ7G26AysG+FZsUQLq0iVyvDc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q05C05 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9368143 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368166|imex:IM-22301-541 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 intact-crc:E11C7E18009AFE64|rigid:pYj/2g+ssQ2lgG8MHhGqBGVVqR8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q05C05 intact:EBI-9356686 intact:EBI-9368143 psi-mi:q96be0_human(display_long) psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368205|imex:IM-22301-543 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|human orfeome collection:12132(identity)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 intact-crc:72B43DB2F47390E9|rigid:Blx5Mpws5Fk7q5WGbZDSi6kGUm4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q05C05 intact:EBI-9357028 intact:EBI-9368143 psi-mi:b4dyc6_human(display_long) psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368185|imex:IM-22301-542 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 intact-crc:E122BDE5DA161797|rigid:4v0NJBW1WeH2rvc0R07xECsmNBI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05C05 uniprotkb:Q15185 intact:EBI-9368143 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368268|imex:IM-22301-546 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:F21C2413745F4C6D|rigid:sqOhF2eCUKUBc2VmMLqutZH7stM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q05C05 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9368143 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368246|imex:IM-22301-545 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 intact-crc:83FE396A102C9E7B|rigid:KB0XKyGZBJjCjRL4I9aql9nD8gY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05C05 uniprotkb:P31948 intact:EBI-9368143 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368227|imex:IM-22301-544 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:4046FF544B942151|rigid:RYd5l31t4HRQ/oJ+AlCR/UU/2uo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q05C32 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9368313 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q05c32_human(display_long)|uniprotkb:PTGER1(gene name)|psi-mi:PTGER1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368310|imex:IM-22301-548 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000708(Prostanoid EP1 receptor)|interpro:IPR008365(Prostanoid receptor)|go:"GO:0004957"(prostaglandin E receptor activity)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q05C32(identity)|human orfeome collection:13642(identity)|entrezgene/locuslink:5731(identity)|ddbj/embl/genbank:BC051286(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:HQVe0HPvR2uJNGCXC7/ezQ1k1PQ9606 intact-crc:6E0FA093CF6ED30A|rigid:eeFTqQaO2JfAXTP6aVlfOC4zQ+o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05C05 uniprotkb:Q9BPW0 intact:EBI-9368143 intact:EBI-9356778 psi-mi:q05c05_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368288|imex:IM-22301-547 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR037854|interpro:IPR043536|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0071339"(MLL1 complex)|uniprotkb:Q05C05(identity)|ddbj/embl/genbank:BC063435(identity)|entrezgene/locuslink:3054(identity)|human orfeome collection:12132(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:TWujqGF9uy1oVQsVPyQ9Mgf7Opo9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:4038FD79AC5D66DF|rigid:JGRU4yf9jpPTBcN2nH5NXjR8Krc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q06609 intact:EBI-9357141 intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8 psi-mi:q9hav2_human(display_long) psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368380|imex:IM-22301-551 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|uniprotkb:Q06609(identity)|entrezgene/locuslink:5888(identity)|ddbj/embl/genbank:BC001459(identity)|human orfeome collection:7467(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606 intact-crc:A48E3849BDF0F8E6|rigid:5xr2NboVxfJoDOvlaNWJlnEJTQE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06609 uniprotkb:P58340 intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368358|imex:IM-22301-550 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|uniprotkb:Q06609(identity)|entrezgene/locuslink:5888(identity)|ddbj/embl/genbank:BC001459(identity)|human orfeome collection:7467(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:DE5D44E77F5BE406|rigid:ggHm7VmL4O+2haVL0P7leePnxOc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05CV4 uniprotkb:Q96RS6 intact:EBI-9368335 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:q05cv4_human(display_long)|uniprotkb:DHX8(gene name)|psi-mi:DHX8(display_short) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368339|imex:IM-22301-549 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001289552.1|refseq:NP_004932.1|uniprotkb:Q05CV4(identity)|entrezgene/locuslink:1659(identity)|human orfeome collection:10737(identity)|ddbj/embl/genbank:BC044586(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:yw0ZxsFgdrgA5Gic7Ikg316nt+89606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:8CCEB6F84C59C379|rigid:pf7PyUBNJ6x1LubQ5hmNPGTPErI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q10587 intact:EBI-9356749 intact:EBI-2796967|uniprotkb:B0QYS8|uniprotkb:Q8IU94|uniprotkb:Q15729|uniprotkb:B2RC22|uniprotkb:Q96TG4|uniprotkb:Q7Z3J7|ensembl:ENSP00000266304 psi-mi:q53fc7_human(display_long) psi-mi:tef_human(display_long)|uniprotkb:KIAA1655(gene name synonym)|uniprotkb:TEF(gene name)|psi-mi:TEF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368424|imex:IM-22301-553 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001138870.1|refseq:NP_003207.1|ensembl:ENSG00000167074(gene)|ensembl:ENST00000266304(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029832|interpro:IPR040223|rcsb pdb:4U5T|uniprotkb:Q10587(identity)|human orfeome collection:2140(identity)|entrezgene/locuslink:7008(identity)|ddbj/embl/genbank:BC039258(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:QXQh9ROTc0D9dcg3Qq76i3b/jFo9606 intact-crc:3614BC9C3CCDD897|rigid:n4S0FJdWOwDL+tyXmBbv7b80xpg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q06609 intact:EBI-9356686 intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8 psi-mi:q96be0_human(display_long) psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368402|imex:IM-22301-552 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|uniprotkb:Q06609(identity)|entrezgene/locuslink:5888(identity)|ddbj/embl/genbank:BC001459(identity)|human orfeome collection:7467(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606 intact-crc:83BF2B162961407C|rigid:xx0t1tpX/39Oy67z/UPm5pxWsKY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q13133 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368507|imex:IM-22301-557 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 intact-crc:993425C877A70971|rigid:0mLV1S/Z/ndY4jZlTV9kPGKOcZk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q13133 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368485|imex:IM-22301-556 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 intact-crc:6E78178ED242FFC3|rigid:KU03fwjj+nNsR4H3CI/BLQoqjug false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q13133 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368466|imex:IM-22301-555 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 intact-crc:0D9D1EF6E86D1B59|rigid:GCoIMcb9uIPi3B3PrfBJRZ44Wds false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13131-2 uniprotkb:Q16543 intact:EBI-6428176|ensembl:ENSP00000346148 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q13131-2(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368446|imex:IM-22301-554 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132356(gene)|ensembl:ENST00000354209(transcript)|intact:EBI-1181405(isoform-parent)|uniprotkb:Q13131-2(isoform-parent)|uniprotkb:Q13131-2(identity)|human orfeome collection:10706(identity)|ddbj/embl/genbank:BC048980(identity)|entrezgene/locuslink:5562(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YAtCEOidvttKJLlIXB7kppPkB6g9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:81422EC8A2114F43|rigid:+Fv086ZIB/4Fbk8NTIHuFRVMRmI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13133 uniprotkb:Q9BTE6-2 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368567|imex:IM-22301-560 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:41E418B0B9B77302|rigid:sSXgpwNlwbYBtvdysmhGdhNvxiI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q13133 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368548|imex:IM-22301-559 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 intact-crc:8BA0D0F992E6E187|rigid:cLTHDAkka/Itt2LWnRfK/5MzY5k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13133 uniprotkb:B4DYC6 intact:EBI-781356|uniprotkb:A8K3J9|uniprotkb:Q96H87|uniprotkb:D3DQR1|uniprotkb:Q8IW13|ensembl:ENSP00000387946|ensembl:ENSP00000420656 intact:EBI-9357028 psi-mi:nr1h3_human(display_long)|uniprotkb:Liver X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 3(gene name synonym)|uniprotkb:NR1H3(gene name)|psi-mi:NR1H3(display_short)|uniprotkb:LXRA(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368528|imex:IM-22301-558 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006718175.1|refseq:XP_006718176.1|refseq:XP_006718178.1|refseq:XP_006718179.1|refseq:NP_001123574.1|refseq:NP_001123573.1|refseq:NP_005684.2|refseq:XP_011518107.1|refseq:XP_005252770.1|refseq:XP_005252762.1|refseq:XP_005252763.1|refseq:XP_005252764.1|refseq:XP_005252766.1|refseq:XP_005252767.1|refseq:XP_016872547.1|ensembl:ENSG00000025434(gene)|ensembl:ENST00000441012(transcript)|ensembl:ENST00000467728(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0032810"(sterol response element binding)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055092"(sterol homeostasis)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090341"(negative regulation of secretion of lysosomal enzymes)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:Q13133|rcsb pdb:1UHL|rcsb pdb:3IPQ|rcsb pdb:3IPS|rcsb pdb:3IPU|rcsb pdb:5AVI|rcsb pdb:5AVL|rcsb pdb:5HJS|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|reactome:R-HSA-9632974|uniprotkb:Q13133(identity)|entrezgene/locuslink:10062(identity)|ddbj/embl/genbank:BC041172(identity)|human orfeome collection:11270(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:o1qZ/nvjBXMWVvnnwindfL0HBFE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:2DA2CD9726875CCD|rigid:2r8X6k+7sl5sMSplD/iO/MgR4f8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q13200 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368630|imex:IM-22301-563 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:F8EEA391FE6A24AF|rigid:wGU6XYKqbshCiR6SkgJvMyOlFdE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P55036 uniprotkb:Q13200 intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368611|imex:IM-22301-562 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|uniprotkb:P55036(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:110CD9FA6745F39D|rigid:OqILFxssh6pZtmYolP3VxHMHN5k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P58340 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368589|imex:IM-22301-561 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:935EC31B1F749D07|rigid:Ui0Aw4zsmCUI7wXj56kUljl47zo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:O43765 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368673|imex:IM-22301-565 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:0C99E110C495CEBA|rigid:Qkt4YV1Y+Fh/kiyVexl25ZCvT7A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q15773 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368651|imex:IM-22301-564 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:8C36BCF1357EE7C5|rigid:rJz1lRDve/ILarlmCS+ppsbtvTA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P31948 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368739|imex:IM-22301-568 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:76125532F1618E4B|rigid:RSILAB2vSe+qmyIbl1/CIKXML/0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q13200 intact:EBI-9356686 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q96be0_human(display_long) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368717|imex:IM-22301-567 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:2FE9B94D48EF08A1|rigid:iACtg2DdCKxtjNig7NRtSl8w0ug false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q99933 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368695|imex:IM-22301-566 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:6E954658D9C44F77|rigid:YFtAL0z9EZpHEM5mKovrC/IZ0QM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q13200 intact:EBI-9356778 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368801|imex:IM-22301-571 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:3F558325B4CAF2B0|rigid:TiB42+7xUnw4zwBXMZM5acrguDE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q13200 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368779|imex:IM-22301-570 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:519C8480869D5B2C|rigid:dD/xlK+Sg0KeruBKpEzC6ZKHGrc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q3UJD6-2 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368758|imex:IM-22301-569 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:81FB7BEB43F850A9|rigid:kyXE7OLg3H3JcumUUWxCAaUdYS8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q13309 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368867|imex:IM-22301-574 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:7E28B483954179E7|rigid:xd/YRdTxZhsfSsEtfi7Bko9j158 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13309 uniprotkb:P58340 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368845|imex:IM-22301-573 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:93CEC94A6D9F1684|rigid:Vx7lsX6s20LxroZFCXm25VSlF14 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HB3 uniprotkb:Q13200 intact:EBI-9362707 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q53hb3_human(display_long) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368823|imex:IM-22301-572 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035244|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|uniprotkb:Q53HB3(identity)|ddbj/embl/genbank:BC000512(identity)|entrezgene/locuslink:5700(identity)|human orfeome collection:4018(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Unfk3E8DIsBKU/b5AIjm4wDR26M9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:F6A19C887FB30CC5|rigid:Pbtj3vbh+IaJ5/sIbEHc6Rj3olI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q13309 intact:EBI-9356686 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:q96be0_human(display_long) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368950|imex:IM-22301-578 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:DE555C2A1E4684CA|rigid:4+MBdNYJrJwoInoy5GC31jyGD8Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q13309 intact:EBI-9357028 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:b4dyc6_human(display_long) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368930|imex:IM-22301-577 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:705DF81FC61019FC|rigid:C+EcaZQ5FhWq8L7cI/p06FUwkTY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q13309 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368911|imex:IM-22301-576 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:9FC11613198E615D|rigid:+XAp04XT75au7e8eOjVCqzHEvj8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q13309 intact:EBI-9356749 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:q53fc7_human(display_long) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368889|imex:IM-22301-575 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:CD5920B3ADFFD7A0|rigid:ejf35Xu3Eyxai1TUWFzagEDY/xg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q13309 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369012|imex:IM-22301-581 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:23AAAE18AF113061|rigid:Q4jvLzHK7ctNBAat/cWZKeE0ESg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q13309 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368993|imex:IM-22301-580 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:23A7AE3CEBB9358B|rigid:ABStacL7grVfiDKexI2xAuO2K9A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13309 uniprotkb:P07900 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9368972|imex:IM-22301-579 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:65CD49D21A818A48|rigid:J1QYvIMyIqksSU+Rumvl2FQK5jo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13309 uniprotkb:Q9BPW0 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 intact:EBI-9356778 psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369072|imex:IM-22301-584 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:34C566372E537F6A|rigid:UzJwEKDRia34/E/tO8trRmp1jl4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q13309 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369050|imex:IM-22301-583 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:63A2AEF8E7952F4B|rigid:YZfaFzMoCgD0HhBJ3h2xu3iXxO0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q13309 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369031|imex:IM-22301-582 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|entrezgene/locuslink:6502(identity)|human orfeome collection:4656(identity)|ddbj/embl/genbank:BC001441(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:E1936486DCAAE8DC|rigid:JKYdIqGi1R8Ov+KhX5nBjSjuNaI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13885 uniprotkb:Q9BTE6-2 intact:EBI-711595|ensembl:ENSP00000369703|uniprotkb:Q6FGZ8|uniprotkb:Q8IWR2 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:tbb2a_human(display_long)|uniprotkb:TUBB2A(gene name)|psi-mi:TUBB2A(display_short)|uniprotkb:TUBB2(gene name synonym)|uniprotkb:Tubulin beta class IIa(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369136|imex:IM-22301-587 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-389957|reactome:R-HSA-983189|reactome:R-HSA-9668328|ensembl:ENSG00000137267(gene)|ensembl:ENST00000333628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001764"(neuron migration)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13885|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|refseq:NP_001060.1|refseq:NP_001297244.1|uniprotkb:Q13885(identity)|human orfeome collection:3357(identity)|entrezgene/locuslink:7280(identity)|ddbj/embl/genbank:BC001194(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:XN9uTGU0KxQjMod0AGnM+XJoHyk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:4078E747DA2BFF70|rigid:8euSdvEQ2ZTKmRF6xrgAZXtuBZQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13620 uniprotkb:Q16543 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369116|imex:IM-22301-586 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314|uniprotkb:Q13620(identity)|human orfeome collection:2214(identity)|ddbj/embl/genbank:BC036216(identity)|entrezgene/locuslink:8450(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:A3B8A45F9863225A|rigid:id8QV75JDg7Rkb/2a07PKpMbQSg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13620 uniprotkb:Q6PK50 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 intact:EBI-9356629 psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369094|imex:IM-22301-585 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314|uniprotkb:Q13620(identity)|human orfeome collection:2214(identity)|ddbj/embl/genbank:BC036216(identity)|entrezgene/locuslink:8450(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:99F236AF25A17858|rigid:TBVNz11TZr3r04dCCFC+Cr9lU1g false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q14145 intact:EBI-9357028 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:b4dyc6_human(display_long) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369177|imex:IM-22301-589 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:C6C269482678A762|rigid:uR6fBOlZIqrXEoRg7gw1/rxyQmo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14145 uniprotkb:Q8IVD9 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369158|imex:IM-22301-588 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:7CA82F32261AEA56|rigid:VRFcKN9yuWbyb/Wa0JZN6irWJ/E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14145 uniprotkb:Q96BE0 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-9356686 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369197|imex:IM-22301-590 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:831F1380BDFA7167|rigid:lI68lRupKzNZHjc5QhGscdfceR0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q14145 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369219|imex:IM-22301-591 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:32588343017F5B30|rigid:PuhkckSv/S0uASuvlUUI8XEJFJI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14145 uniprotkb:Q9HB71 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369238|imex:IM-22301-592 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:6BEF1D901D81678C|rigid:tj1lZzDg22kpYW3ubbS8dPswmE0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14164 uniprotkb:Q6PK50 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 intact:EBI-9356629 psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369300|imex:IM-22301-595 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:A0C881355DF73F12|rigid:pyvss0VBTLWlzTGddag8UV5Mwy4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14145 uniprotkb:Q9BTE6-2 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369257|imex:IM-22301-593 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|human orfeome collection:244(identity)|ddbj/embl/genbank:BC002417(identity)|entrezgene/locuslink:9817(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:9A4F5817F0699487|rigid:zL7zcki7vCJjV5bTVb6VhS5teaA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q14164 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369279|imex:IM-22301-594 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 intact-crc:D2E3523C8660F9E9|rigid:iugmf+QAPtIktEdWEQP/rQ7URY4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14164 uniprotkb:Q3UJD6-1 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369366|imex:IM-22301-598 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:FD4C732E2600CEC5|rigid:zDzG5UHmmnTiydG6H2+epc3r6FE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14164 uniprotkb:O95816 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369344|imex:IM-22301-597 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:D5BF0DF0D1163954|rigid:S4qxlyGZXHuTWQdh8NedGk/69ZY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q14164 intact:EBI-9356749 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 psi-mi:q53fc7_human(display_long) psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369322|imex:IM-22301-596 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 intact-crc:923C1DC8CAD97D83|rigid:1skvoZ1JQRMrxoRlPSKW2YY1OpA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q14164 intact:EBI-9356686 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 psi-mi:q96be0_human(display_long) psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369387|imex:IM-22301-599 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 intact-crc:9CEF68B1C06B51E0|rigid:FkXSCZHcnKnAawzof/+E/g15M30 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q14164 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-307369|uniprotkb:Q3KR43|uniprotkb:Q5JTS6|uniprotkb:D3DT78|ensembl:ENSP00000464030|uniprotkb:Q3B754 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ikke_human(display_long)|uniprotkb:IKBKE(gene name)|psi-mi:IKBKE(display_short)|uniprotkb:IKKE(gene name synonym)|uniprotkb:IKKI(gene name synonym)|uniprotkb:KIAA0151(gene name synonym)|uniprotkb:Inducible I kappa-B kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369409|imex:IM-22301-600 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001180250.1|refseq:NP_001180251.1|refseq:NP_054721.1|ensembl:ENSG00000263528(gene)|ensembl:ENST00000581977(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010467"(gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0098586"(cellular response to virus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q14164|reactome:R-HSA-4755510|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|refseq:XP_005273413.1|dip:DIP-27530N|uniprotkb:Q14164(identity)|ddbj/embl/genbank:BC107812(identity)|entrezgene/locuslink:9641(identity)|human orfeome collection:52921(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Ml1E20UjGfHuuL3MqOLVBbv8ZmU9606 intact-crc:07AF8629957EECE7|rigid:ZrKt2VUmXgnWbnvNAV6D9VhVErc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q13451 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369429|imex:IM-22301-601 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:AACC47F4E96B7CE6|rigid:IdlEHctOP3qa3Wa+pDi40Qwmo6o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q8K2C9 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369470|imex:IM-22301-603 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 intact-crc:F5F6108BF09C1048|rigid:Ddkpj9kmUdSCHNjvTFJ0wfYQDQ4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q15773 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369491|imex:IM-22301-604 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:F8A1430F464B3579|rigid:FyZ4ooNMNVZ5UvCqrnkZp6GYjAI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:P58340 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369448|imex:IM-22301-602 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:E895D6DAC2F66C9F|rigid:yfBhwenXO0HEi8eiYFJZxlSj1bo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:O95429 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369535|imex:IM-22301-606 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:B96B9AB826DB20A2|rigid:BU65m5dfoVyN+LII0VBQO9Kjido false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q6PK50 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9356629 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369513|imex:IM-22301-605 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:BD4172F36E584718|rigid:wim8EOWrBMvk//j1pmEJFDKT+vc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9Y266 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369557|imex:IM-22301-607 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:89515DDEA98B51A9|rigid:4BNKa31nUvFzU8GZFHWcGQ1YIZ4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:O95816 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369576|imex:IM-22301-608 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:054973C47D96EF4B|rigid:HrDMhe71OEvnCnpl41vbQWniCoI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9HAV2 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9357141 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369598|imex:IM-22301-609 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:38B3755E1AB0F494|rigid:4aiIQbxwoa8QiteCXQCR+CxJpr8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q8IVD9 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369642|imex:IM-22301-611 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:84ED9B4E2025D76B|rigid:oWLuCV/Ox/gy0zfXi/UPflvuZo8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:P04792 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369620|imex:IM-22301-610 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|entrezgene/locuslink:3315(identity)|ddbj/embl/genbank:BC012292(identity)|human orfeome collection:618(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:371F0E256D09AD23|rigid:jCYAiq2FrzNGBsHLGIgXnvEY8gQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:B4DYC6 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9357028 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369661|imex:IM-22301-612 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:B2D8A30B40FFECAE|rigid:sABrlwhnmylT4pFMi1DhtSvYRZc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q13200 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369681|imex:IM-22301-613 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:F96F7DBA66DA209C|rigid:y/uPhCkVXdKllObCk8aXZKvoC3A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:O43765 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369703|imex:IM-22301-614 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:146C7DA5594B5819|rigid:NacS0D5r9R59YkHDNDPurC4Yrro false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:P31948 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369747|imex:IM-22301-616 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:8AB9E720308B1652|rigid:Z1/H0ifVa8dPsNv1iSKO8Dh2pZg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q96BE0 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9356686 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369725|imex:IM-22301-615 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:3A2B1BE85BDC86E9|rigid:F+R3ae+FQ22dia5KQ9k3fniauaI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9UIM3 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369766|imex:IM-22301-617 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:53707297606340D8|rigid:99SlSBxVMGjUN7prAfF1YQLlhzQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9HB71 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369807|imex:IM-22301-619 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:A49E0DA1B7D79F5D|rigid:Dcccih/32pLYKMVuXWwRgX1UMtk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:O00170 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369826|imex:IM-22301-620 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:1ADF4DA61EA05A3A|rigid:sUcS8xNXIkVF0ypz7YD3gOtfqV0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9UNE7 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369785|imex:IM-22301-618 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:C572DED738E501F4|rigid:8OYIbmrC6OoD6C5az7YNU9dnFNE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q15185 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369845|imex:IM-22301-621 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:05E952F166C80F32|rigid:j5wLKSTCYpdFKa1TCHybGwo3Uqc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9BTE6-2 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369865|imex:IM-22301-622 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:8FDED9092E8D81CB|rigid:TrKW7DCkWB6OFR4DDwnO+z034LI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q9BPW0 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-9356778 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369887|imex:IM-22301-623 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:70FDE14E361C8E6F|rigid:P8cSTItMlfQKkHr77nVxHG484Kg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14249 uniprotkb:Q8WW22 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369934|imex:IM-22301-625 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255|uniprotkb:Q14249(identity)|human orfeome collection:4045(identity)|ddbj/embl/genbank:BC004922(identity)|entrezgene/locuslink:2021(identity) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 intact-crc:8BE37A97D1F334DC|rigid:/M2Jm/D/SmWveT9uRnkDBIjUS9o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14190 uniprotkb:Q99614 intact:EBI-6427100|intact:EBI-28974779|uniprotkb:Q15473|uniprotkb:Q15472|uniprotkb:Q2TBD8|uniprotkb:Q15470|uniprotkb:O60766|uniprotkb:Q15471|uniprotkb:Q16532|ensembl:ENSP00000290399 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:sim2_human(display_long)|uniprotkb:SIM2(gene name)|psi-mi:SIM2(display_short)|uniprotkb:BHLHE15(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 15(gene name synonym) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369909|imex:IM-22301-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000290399|refseq:NP_005060.1|refseq:NP_033664.2|ensembl:ENSG00000159263(gene)|ensembl:ENST00000290399(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000014(PAS)|interpro:IPR001610(PAC motif)|interpro:IPR010578(Single-minded, C-terminal)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|uniprotkb:Q14190(identity)|entrezgene/locuslink:6493(identity)|human orfeome collection:52877(identity)|ddbj/embl/genbank:BC110444(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KPLBJANh+y0Rkme/0HS4svACqoc9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:CE4076C8C837CBB1|rigid:rrDU5x2ChlNjV61W/hLt0RNXZlE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q14249 intact:EBI-9356686 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:q96be0_human(display_long) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369956|imex:IM-22301-626 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255|uniprotkb:Q14249(identity)|human orfeome collection:4045(identity)|ddbj/embl/genbank:BC004922(identity)|entrezgene/locuslink:2021(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 intact-crc:1DABDA2B23396FF0|rigid:hL7i2bTGplfg2nV4qM4X3AtY37Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q14257 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9369978|imex:IM-22301-627 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1|uniprotkb:Q14257(identity)|entrezgene/locuslink:5955(identity)|human orfeome collection:3509(identity)|ddbj/embl/genbank:BC004892(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 intact-crc:9442BD9987409468|rigid:zO2UvWjxFxKUWObU8EVozwGV1rA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q14257 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370000|imex:IM-22301-628 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1|uniprotkb:Q14257(identity)|entrezgene/locuslink:5955(identity)|human orfeome collection:3509(identity)|ddbj/embl/genbank:BC004892(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 intact-crc:2122E6B258D69199|rigid:6Cj8RxAuqWKsLrTm/tVo51WOQWQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14257 uniprotkb:Q15773 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370021|imex:IM-22301-629 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1|uniprotkb:Q14257(identity)|entrezgene/locuslink:5955(identity)|human orfeome collection:3509(identity)|ddbj/embl/genbank:BC004892(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:A644478903A41379|rigid:uaMP4oFhrtgrr0BaG/5o+r6VKDM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14257 uniprotkb:Q9UIM3 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370043|imex:IM-22301-630 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1|uniprotkb:Q14257(identity)|entrezgene/locuslink:5955(identity)|human orfeome collection:3509(identity)|ddbj/embl/genbank:BC004892(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:40E0914E200F0E50|rigid:d6qbSD/M5dG4UYA474YjNS5OWR4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14318 uniprotkb:Q6PK50 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-9356629 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370062|imex:IM-22301-631 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|human orfeome collection:6808(identity)|ddbj/embl/genbank:BC009966(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:3F2B20152846B154|rigid:h9WTVAux3JpUJWDR8V+dzQKxUIA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q14318 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370084|imex:IM-22301-632 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|human orfeome collection:6808(identity)|ddbj/embl/genbank:BC009966(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 intact-crc:B06EE667D1580BCE|rigid:rqfOQTZG1j9dVPT6FwaLykiFLwU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14344 uniprotkb:B4DYC6 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 intact:EBI-9357028 psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370125|imex:IM-22301-634 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1|uniprotkb:Q14344(identity)|entrezgene/locuslink:10672(identity)|ddbj/embl/genbank:BC036756(identity)|human orfeome collection:10149(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:8E5F47C8EB0EC10A|rigid:S/Jxpp8fXxSIf2T6+UPC/+KNh9o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q14318 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370103|imex:IM-22301-633 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|human orfeome collection:6808(identity)|ddbj/embl/genbank:BC009966(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 intact-crc:D99401A2D8EED9FB|rigid:1LxBLWnRYOuXIKZCoWad9QvKFV0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q14344 intact:EBI-9356686 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 psi-mi:q96be0_human(display_long) psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370145|imex:IM-22301-635 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1|uniprotkb:Q14344(identity)|entrezgene/locuslink:10672(identity)|ddbj/embl/genbank:BC036756(identity)|human orfeome collection:10149(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 intact-crc:CF89D62B652EECCD|rigid:5p1RnYnsM2ah0BuL15YTdcc1eAU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14344 uniprotkb:Q9BTE6-2 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370186|imex:IM-22301-637 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1|uniprotkb:Q14344(identity)|entrezgene/locuslink:10672(identity)|ddbj/embl/genbank:BC036756(identity)|human orfeome collection:10149(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:8A7CDFB3FD9829FA|rigid:ziOLZborpehIjkFd8spU7EOcHHA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14344 uniprotkb:Q9HB71 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370167|imex:IM-22301-636 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1|uniprotkb:Q14344(identity)|entrezgene/locuslink:10672(identity)|ddbj/embl/genbank:BC036756(identity)|human orfeome collection:10149(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:1466A4039FEAAD5E|rigid:SvhNn5QuFbNLyvAazd7/yTduvks false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95433 uniprotkb:Q14653-4 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-9370208|ensembl:ENSP00000471896 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:q14653-4(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370212|imex:IM-22301-638 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity) ensembl:ENSG00000126456(gene)|ensembl:ENST00000601291(transcript)|intact:EBI-2650369(isoform-parent)|uniprotkb:Q14653-4(identity)|human orfeome collection:6832(identity)|ddbj/embl/genbank:BC009395(identity)|entrezgene/locuslink:3661(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:YrHk8L1VhGeuHxZ51q1odaO3R+M9606 intact-crc:B0D98A2B5C1E7176|rigid:angxgaefhGMQZu+97DBBlY8xUuI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14653-4 uniprotkb:Q96BE0 intact:EBI-9370208|ensembl:ENSP00000471896 intact:EBI-9356686 psi-mi:q14653-4(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370231|imex:IM-22301-639 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126456(gene)|ensembl:ENST00000601291(transcript)|intact:EBI-2650369(isoform-parent)|uniprotkb:Q14653-4(identity)|human orfeome collection:6832(identity)|ddbj/embl/genbank:BC009395(identity)|entrezgene/locuslink:3661(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) isoform-comment:No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YrHk8L1VhGeuHxZ51q1odaO3R+M9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1A6F4F3AB0ED3D16|rigid:pzcs6TUEVlojG3DfKkbIPQF0ZOc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14653-4 uniprotkb:Q53FC7 intact:EBI-9370208|ensembl:ENSP00000471896 intact:EBI-9356749 psi-mi:q14653-4(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370253|imex:IM-22301-640 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126456(gene)|ensembl:ENST00000601291(transcript)|intact:EBI-2650369(isoform-parent)|uniprotkb:Q14653-4(identity)|human orfeome collection:6832(identity)|ddbj/embl/genbank:BC009395(identity)|entrezgene/locuslink:3661(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) isoform-comment:No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YrHk8L1VhGeuHxZ51q1odaO3R+M9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:07684C28E6E80618|rigid:GYYciUylu8bXkd3rnOw13ziTEI8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q14653-4 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9370208|ensembl:ENSP00000471896 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q14653-4(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370275|imex:IM-22301-641 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000126456(gene)|ensembl:ENST00000601291(transcript)|intact:EBI-2650369(isoform-parent)|uniprotkb:Q14653-4(identity)|human orfeome collection:6832(identity)|ddbj/embl/genbank:BC009395(identity)|entrezgene/locuslink:3661(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:YrHk8L1VhGeuHxZ51q1odaO3R+M9606 intact-crc:965A36152CC31674|rigid:r9ZDwjuIkpK75Qmpjt22MIsqLZI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q14653-4 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9370208|ensembl:ENSP00000471896 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q14653-4(display_long)|uniprotkb:IRF3(gene name)|psi-mi:IRF3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370296|imex:IM-22301-642 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000126456(gene)|ensembl:ENST00000601291(transcript)|intact:EBI-2650369(isoform-parent)|uniprotkb:Q14653-4(identity)|human orfeome collection:6832(identity)|ddbj/embl/genbank:BC009395(identity)|entrezgene/locuslink:3661(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:YrHk8L1VhGeuHxZ51q1odaO3R+M9606 intact-crc:73D3AAEC60E36C21|rigid:eaRdIY8MqSRyTdETRX7Fml++Zlc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15014 uniprotkb:Q13451 intact:EBI-399257|uniprotkb:B3KP92|uniprotkb:Q567V0|uniprotkb:Q8J026|uniprotkb:D3DXA5|ensembl:ENSP00000353643|ensembl:ENSP00000391969|ensembl:ENSP00000410532|ensembl:ENSP00000415476 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:mo4l2_human(display_long)|uniprotkb:MORF4L2(gene name)|psi-mi:MORF4L2(display_short)|uniprotkb:KIAA0026(gene name synonym)|uniprotkb:MRGX(gene name synonym)|uniprotkb:MORF-related gene X protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRGX(gene name synonym)|uniprotkb:Protein MSL3-2(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370318|imex:IM-22301-643 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135894.1|refseq:NP_001135895.1|refseq:NP_001135896.1|refseq:NP_001135897.1|refseq:NP_001135898.1|refseq:NP_001135899.1|refseq:NP_001135900.1|refseq:NP_001135901.1|refseq:NP_001135902.1|refseq:NP_001135903.1|refseq:NP_001135904.1|refseq:NP_036418.1|refseq:NP_001135890.1|refseq:NP_001135891.1|refseq:NP_001135892.1|refseq:NP_001135893.1|ensembl:ENSG00000123562(gene)|ensembl:ENST00000360458(transcript)|ensembl:ENST00000433176(transcript)|ensembl:ENST00000441076(transcript)|ensembl:ENST00000451301(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR008676(MRG)|interpro:IPR026541|interpro:IPR038012|interpro:IPR038217|mint:Q15014|reactome:R-HSA-3214847|uniprotkb:Q15014(identity)|human orfeome collection:11965(identity)|entrezgene/locuslink:9643(identity)|ddbj/embl/genbank:BC056899(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:7SlnJWNVhfdzirTHBEseWbJQjyU9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:D7DD773A47D23FBF|rigid:p3F7SrZaXZsHR1sTXJRil+cCbaM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15029 uniprotkb:Q96BE0 intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81 intact:EBI-9356686 psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370337|imex:IM-22301-644 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1|uniprotkb:Q15029(identity)|entrezgene/locuslink:9343(identity)|human orfeome collection:4666(identity)|ddbj/embl/genbank:BC002360(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:333C191CE6C681A8|rigid:c3aHo5s6siCOzOj32V1MqS8pR2s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q15029 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370359|imex:IM-22301-645 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1|uniprotkb:Q15029(identity)|entrezgene/locuslink:9343(identity)|human orfeome collection:4666(identity)|ddbj/embl/genbank:BC002360(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606 intact-crc:438B57AEDC9BDE12|rigid:xpubdWD2UyUUsSjSzZoE5W+El6A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q15047 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370378|imex:IM-22301-646 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:87EEB1849D0EC659|rigid:HISa2w5QUMwLnsqVSg89+A1WZvM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q15047 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370400|imex:IM-22301-647 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:30A4830C21E929BC|rigid:rtJt1ON1KKMyAer7R1GrgMvVMhY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15047 uniprotkb:Q15773 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370421|imex:IM-22301-648 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:51C4199DA81D2886|rigid:SIne+WZAaeIT8NJNwZuw+JEG9zo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q15047 intact:EBI-9356629 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370443|imex:IM-22301-649 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:2D52A4678A80EF00|rigid:CiU4SE79e/+ugEzPVxih73fbGyY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15047 uniprotkb:Q8IVD9 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370465|imex:IM-22301-650 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:476CA4EB57C4AACF|rigid:iO7TbVw5AFnTM/JVK/Q7b2JYOE0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15047 uniprotkb:B4DYC6 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 intact:EBI-9357028 psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370484|imex:IM-22301-651 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:9554D9A1C99A87C4|rigid:KkYu4zeZvwMJJoib6sWAvHJpm/Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:Q15047 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370504|imex:IM-22301-652 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:3E586A2A0B7D0053|rigid:tGqf3ssNmrNGYjTNi/0uWgWwrwo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15047 uniprotkb:Q9BTE6-2 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370567|imex:IM-22301-655 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:8F87D2377E8213C9|rigid:iXBkVAN7v4mfq5MI3yEL84egMB8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q15047 intact:EBI-9356686 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:q96be0_human(display_long) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370526|imex:IM-22301-653 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:0AF3DE9A32A43CBE|rigid:p/FGD0g7X4yUi/+7i1YGApPENhY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q15047 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-79691|ensembl:ENSP00000271640|uniprotkb:A6NEW2|uniprotkb:Q5SZD8|uniprotkb:Q5SZD9|uniprotkb:Q5SZE0|uniprotkb:Q5SZE7|uniprotkb:Q96GM9 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:setb1_human(display_long)|uniprotkb:SETDB1(gene name)|psi-mi:SETDB1(display_short)|uniprotkb:KIAA0067(gene name synonym)|uniprotkb:KMT1E(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 4(gene name synonym)|uniprotkb:Lysine N-methyltransferase 1E(gene name synonym)|uniprotkb:ESET(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370548|imex:IM-22301-654 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000143379(gene)|ensembl:ENST00000271640(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005694"(chromosome)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033273"(response to vitamin)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR002999(Tudor)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR025796|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|mint:Q15047|rcsb pdb:3DLM|rcsb pdb:4X3S|rcsb pdb:5KCH|rcsb pdb:5KCO|rcsb pdb:5KE2|rcsb pdb:5KE3|rcsb pdb:5KH6|rcsb pdb:5QT1|rcsb pdb:5QT2|rcsb pdb:6AU2|rcsb pdb:6AU3|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6BPI|rcsb pdb:7C9N|rcsb pdb:7CAJ|rcsb pdb:7CD9|rcsb pdb:7CJT|reactome:R-HSA-3214841|refseq:NP_001138887.1|refseq:NP_001230420.1|refseq:NP_036564.3|refseq:XP_016858444.1|dip:DIP-31029N|uniprotkb:Q15047(identity)|human orfeome collection:12474(identity)|entrezgene/locuslink:9869(identity)|ddbj/embl/genbank:BC028671(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:ydyGndAZ5b35jF07y4WFUeHFFvE9606 intact-crc:225EE9553E5548DE|rigid:5pNB6DJRvY7I26+xVK241ir7WlQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q15078 intact:EBI-9357141 intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486 psi-mi:q9hav2_human(display_long) psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370611|imex:IM-22301-657 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N|uniprotkb:Q15078(identity)|entrezgene/locuslink:8851(identity)|human orfeome collection:1008(identity)|ddbj/embl/genbank:BC020580(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606 intact-crc:25DC2DE8C67117EA|rigid:Y9MojzGiGpxFHdA+XraaMlbWBBY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q15078 intact:EBI-9356749 intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486 psi-mi:q53fc7_human(display_long) psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370589|imex:IM-22301-656 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N|uniprotkb:Q15078(identity)|entrezgene/locuslink:8851(identity)|human orfeome collection:1008(identity)|ddbj/embl/genbank:BC020580(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606 intact-crc:64130CAE7D2F2A8A|rigid:Bnz+eKW+VvJbRK+18BIkczDwPmA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15078 uniprotkb:Q96BE0 intact:EBI-746189|uniprotkb:Q5U0G3|uniprotkb:E1P664|ensembl:ENSP00000318486 intact:EBI-9356686 psi-mi:cd5r1_human(display_long)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym)|uniprotkb:CDK5R1(gene name)|psi-mi:CDK5R1(display_short)|uniprotkb:CDK5R(gene name synonym)|uniprotkb:NCK5A(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370633|imex:IM-22301-658 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003876.1|refseq:XP_011523740.1|ensembl:ENSG00000176749(gene)|ensembl:ENST00000313401(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043005"(neuron projection)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|rcsb pdb:1H4L|rcsb pdb:1UNG|rcsb pdb:1UNH|rcsb pdb:1UNL|rcsb pdb:3O0G|rcsb pdb:6LDP|rcsb pdb:7CNG|reactome:R-HSA-399956|reactome:R-HSA-6804756|reactome:R-HSA-8862803|reactome:R-HSA-9031628|reactome:R-HSA-9032845|refseq:XP_016880770.1|dip:DIP-24222N|uniprotkb:Q15078(identity)|entrezgene/locuslink:8851(identity)|human orfeome collection:1008(identity)|ddbj/embl/genbank:BC020580(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:v4E2UWg0EgZM8lUhSUpirwaIONw9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:BB42DC65F6A4EDE6|rigid:XUCfmizMYriJBiI/2dPCK9aU8/E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q15131-3 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9370658 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q15131-3(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370655|imex:IM-22301-659 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) intact:EBI-1646959(isoform-parent)|uniprotkb:Q15131-3(identity)|ddbj/embl/genbank:BC025301(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:55257(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Wc5jIN8RCX+ZoQj/HdpZLcMUdwc9606 intact-crc:A8AC6522872F7670|rigid:muYRk38x5e4reZCIJmbVhv91x7k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15131-4 uniprotkb:Q8IVD9 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370684|imex:IM-22301-660 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:268231C5E7C5783C|rigid:NWkIwfnrVjV262m4s0j5/Cv4u2E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q15131-4 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370703|imex:IM-22301-661 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:9C7874FA241A3E4A|rigid:O0FgatVhFTIFqIdmuYOJ6xB4Ki4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q15131-4 intact:EBI-9356686 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:q96be0_human(display_long) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370725|imex:IM-22301-662 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:E005F7B39771B46E|rigid:zVFjX4gYyHybxk1ZGM2XlBrht9k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q15131-4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370747|imex:IM-22301-663 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:1D727008B19DABEF|rigid:EdpeouJiSEMImhHd+X0GpxetWvA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q15131-4 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370789|imex:IM-22301-665 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:FFEE24DE6730922B|rigid:AB7sc5QYXB4i/kCVAByxZNuKg6k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q15131-4 intact:EBI-9356629 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370767|imex:IM-22301-664 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:E56C5B57E31D0311|rigid:7U74Pv5gzBAGlVw1p6PF9kNWZLM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q15131-4 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370808|imex:IM-22301-666 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 intact-crc:85D50D3D936E6456|rigid:+eU433XM3KeIp1QDKTmibC7jbTI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15131-4 uniprotkb:Q9BPW0 intact:EBI-9370680|ensembl:ENSP00000424415|ensembl:ENSP00000484357 intact:EBI-9356778 psi-mi:q15131-4(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Cell division protein kinase 10(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370829|imex:IM-22301-667 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1646959(isoform-parent)|ensembl:ENSG00000185324(gene)|ensembl:ENST00000505473(transcript)|ensembl:ENST00000617879(transcript)|uniprotkb:Q15131-4(identity)|ddbj/embl/genbank:BC017342(identity)|entrezgene/locuslink:8558(identity)|human orfeome collection:13509(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Og2mgc6Ii2NBrAiJHRcI26Zkxzg9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:7529BBAA468773B1|rigid:6xG0VSMnzoyd/SEiCrhUqzvBobE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q15293 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370851|imex:IM-22301-668 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1|uniprotkb:Q15293(identity)|human orfeome collection:6932(identity)|entrezgene/locuslink:5954(identity)|ddbj/embl/genbank:BC010120(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 intact-crc:4F3D0638D02D68DC|rigid:HJFWb693n3RdNGrL9rNbpLVibDU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15393 uniprotkb:Q8IVD9 intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370873|imex:IM-22301-669 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE|uniprotkb:Q15393(identity)|entrezgene/locuslink:23450(identity)|human orfeome collection:8879(identity)|ddbj/embl/genbank:BC000463(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:67F0C17D1A34B25A|rigid:39JkGUKls3rqCSrOpR1RXIgssn0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q15393 intact:EBI-9357028 intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790 psi-mi:b4dyc6_human(display_long) psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370892|imex:IM-22301-670 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE|uniprotkb:Q15393(identity)|entrezgene/locuslink:23450(identity)|human orfeome collection:8879(identity)|ddbj/embl/genbank:BC000463(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606 intact-crc:32D30ACF73D55424|rigid:RktECx9lrxoqrQpta8RWOI1pI4Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15393 uniprotkb:Q96BE0 intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790 intact:EBI-9356686 psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370912|imex:IM-22301-671 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE|uniprotkb:Q15393(identity)|entrezgene/locuslink:23450(identity)|human orfeome collection:8879(identity)|ddbj/embl/genbank:BC000463(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:3A97D282CB2434B6|rigid:Y/R1sU4ia0AEDKwGxbpIzmZDGSQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15562-2 uniprotkb:B4DYC6 intact:EBI-9370956|ensembl:ENSP00000366419|ensembl:ENSP00000469672 intact:EBI-9357028 psi-mi:q15562-2(display_long)|uniprotkb:TEAD2(gene name)|psi-mi:TEAD2(display_short)|uniprotkb:TEA domain family member 2(gene name synonym)|uniprotkb:TEF4(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370960|imex:IM-22301-673 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000074219(gene)|ensembl:ENST00000377214(transcript)|ensembl:ENST00000601519(transcript)|intact:EBI-6427252(isoform-parent)|uniprotkb:Q15562-2(isoform-parent)|uniprotkb:Q15562-2(identity)|entrezgene/locuslink:8463(identity)|ddbj/embl/genbank:BC051301(identity)|human orfeome collection:13622(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Yi5GBNbuYPF1uAXKVQlt1CxCDR09606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:4F47F2D81A4A83E9|rigid:fSM2PRsD5bB2DVt0miTu9SIeAlg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15393 uniprotkb:Q9BPW0 intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790 intact:EBI-9356778 psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370934|imex:IM-22301-672 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE|uniprotkb:Q15393(identity)|entrezgene/locuslink:23450(identity)|human orfeome collection:8879(identity)|ddbj/embl/genbank:BC000463(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:BBEE921E407465E9|rigid:Up0+Zjm78kRzvImBF0yWv3vcfWM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15750 uniprotkb:Q53FC7 intact:EBI-358643|uniprotkb:Q2PP09|intact:EBI-3959873|uniprotkb:Q8IZW2|ensembl:ENSP00000216160 intact:EBI-9356749 psi-mi:tab1_human(display_long)|uniprotkb:TAB1(gene name)|psi-mi:TAB1(display_short)|uniprotkb:MAP3K7IP1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9370980|imex:IM-22301-674 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006107.1|refseq:NP_705717.1|ensembl:ENSP00000216160|ensembl:ENST00000331454|ensembl:ENSP00000333049|go:"GO:0003279"(cardiac septum development)|rcsb pdb:7NTI|go:"GO:0003007"(heart morphogenesis)|ensembl:ENSG00000100324(gene)|ensembl:ENST00000216160(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q15750|rcsb pdb:2J4O|rcsb pdb:2POM|rcsb pdb:2POP|rcsb pdb:2YDS|rcsb pdb:2YIY|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4GS6|rcsb pdb:4KA3|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5DIY|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5V5N|rcsb pdb:5VVU|rcsb pdb:7NTH|reactome:R-HSA-168638|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27524N|uniprotkb:Q15750(identity)|human orfeome collection:11706(identity)|ddbj/embl/genbank:BC050554(identity)|entrezgene/locuslink:10454(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity)|uniprotkb:Q53FC7(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:28+bzs6bpXJTun4XukxC/7oAYSs9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:4BC1E0B9CF9D1B8B|rigid:L/CRz5RAdmj2DU1QNnHNTc9XTL0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15831 uniprotkb:Q13451 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371002|imex:IM-22301-675 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:8E38B34D48D29901|rigid:Iort/aruRxUZldp7SoN7VrTzPIk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q15831 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371043|imex:IM-22301-677 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:C4E8BFB0BCDABD7E|rigid:u1Q5Xv3cObv1sDL9cLjaiPM6uWo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15831 uniprotkb:P58340 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371021|imex:IM-22301-676 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:02A9B011E80B90E5|rigid:zr8byNT8Zz4+0SnUBeIAjp+B7Mo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:Q15831 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371108|imex:IM-22301-680 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:D98F2D5EA28EFE02|rigid:S0UWp/XBx1MZ81xyz857PlQrr3E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q15831 intact:EBI-9356629 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371086|imex:IM-22301-679 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:E5B980240E62C494|rigid:5i8SbronGykccn6SOiUjwLOMda4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15831 uniprotkb:Q15773 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371064|imex:IM-22301-678 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:782E632DDE6F5FCC|rigid:czhnylXUxuM3u8FvB+02uz+1zbQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q15831 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371130|imex:IM-22301-681 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:14BDB5B031E961E8|rigid:wshV8tR3GDbVSUwb0BhDzV4R4ls false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q15831 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371151|imex:IM-22301-682 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:BA69ACA262559BCA|rigid:EpAjNIFEyqZom5zn2Gq7ohSE0mM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q15831 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371170|imex:IM-22301-683 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:C8C4769D01C49380|rigid:BolHdjTJo2wQxdCTTWAHn2xGLNo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q15831 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371190|imex:IM-22301-684 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:731CC97B9D6653D8|rigid:fP/ORBUv2Csb6OitlQUYS3+SadI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15185 uniprotkb:Q15831 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371212|imex:IM-22301-685 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N|uniprotkb:Q15831(identity)|human orfeome collection:5410(identity)|ddbj/embl/genbank:BC007981(identity)|entrezgene/locuslink:6794(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:18550C986325F2F9|rigid:BNOwJTU/Gi0RAEBcJyBYaX2X/SI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q15850 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9371232 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q15850_human(display_long)|uniprotkb:urf-ret(gene name)|psi-mi:urf-ret(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371236|imex:IM-22301-686 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q15850(identity)|entrezgene/locuslink:5979(identity)|human orfeome collection:4203(identity)|ddbj/embl/genbank:BC004257(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:fMudTpcRbXTNWgvjzOwE+mY1ZoY9606 intact-crc:1392F400257738A9|rigid:GnDz5S3Xl1TqX6JInYTHWu/E+Yc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q15850 intact:EBI-9356629 intact:EBI-9371232 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q15850_human(display_long)|uniprotkb:urf-ret(gene name)|psi-mi:urf-ret(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371257|imex:IM-22301-687 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q15850(identity)|entrezgene/locuslink:5979(identity)|human orfeome collection:4203(identity)|ddbj/embl/genbank:BC004257(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:fMudTpcRbXTNWgvjzOwE+mY1ZoY9606 intact-crc:B362EDC32070252E|rigid:btNigKa2JPLqP0iTt7Y0wKGxju8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q16221 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9371302 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q16221_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371299|imex:IM-22301-689 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|uniprotkb:Q16221(identity)|human orfeome collection:7463(identity)|ddbj/embl/genbank:BC002541(identity)|entrezgene/locuslink:5261(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:9NHopMccvYd4Sn097PyA3ZR5rjc9606 intact-crc:42E29F38C8EF0E8A|rigid:LufVPxy92ygBpvtVmE92KJgw5uI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15850 uniprotkb:Q16543 intact:EBI-9371232 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q15850_human(display_long)|uniprotkb:urf-ret(gene name)|psi-mi:urf-ret(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371279|imex:IM-22301-688 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q15850(identity)|entrezgene/locuslink:5979(identity)|human orfeome collection:4203(identity)|ddbj/embl/genbank:BC004257(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fMudTpcRbXTNWgvjzOwE+mY1ZoY9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:FEC0495E8D338B2B|rigid:y7j1k9CjBgJUngyYllzH9KKuGr8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q16221 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9371302 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q16221_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371323|imex:IM-22301-690 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|uniprotkb:Q16221(identity)|human orfeome collection:7463(identity)|ddbj/embl/genbank:BC002541(identity)|entrezgene/locuslink:5261(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:9NHopMccvYd4Sn097PyA3ZR5rjc9606 intact-crc:7CC4BA348F5F14BB|rigid:/Tf8MYKQRxo6md9zoa+NjBukrQY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16221 uniprotkb:Q9BTE6-2 intact:EBI-9371302 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q16221_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371345|imex:IM-22301-691 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0004689"(phosphorylase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005964"(phosphorylase kinase complex)|uniprotkb:Q16221(identity)|human orfeome collection:7463(identity)|ddbj/embl/genbank:BC002541(identity)|entrezgene/locuslink:5261(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9NHopMccvYd4Sn097PyA3ZR5rjc9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:0E5239EE10B04756|rigid:Xmay02xUAsDZRluZAI0rj749RBQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16513 uniprotkb:P07900 intact:EBI-2511350|uniprotkb:Q9H1W4|uniprotkb:D3DT24|uniprotkb:B4DQ21|uniprotkb:B4DTP5|uniprotkb:B4DVG1|uniprotkb:Q08AF4|ensembl:ENSP00000359552 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:pkn2_human(display_long)|uniprotkb:PKN2(gene name)|psi-mi:PKN2(display_short)|uniprotkb:PRK2(gene name synonym)|uniprotkb:PRKCL2(gene name synonym)|uniprotkb:Protein kinase C-like 2(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 2(gene name synonym)|uniprotkb:PKN gamma(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371367|imex:IM-22301-692 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011540074.1|refseq:NP_006247.1|refseq:NP_001307636.1|refseq:NP_001307637.1|refseq:NP_001307638.1|ensembl:ENSG00000065243(gene)|ensembl:ENST00000370521(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037784|mint:Q16513|rcsb pdb:4CRS|rcsb pdb:4RRV|rcsb pdb:6CCY|rcsb pdb:6GBE|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0032467"(positive regulation of cytokinesis)|uniprotkb:Q16513(identity)|entrezgene/locuslink:5586(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KvHDOJ75CgHIGDC+41jGKORm2+w9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:0D1D0CCF0B5DCF6E|rigid:N6e36XqffYV0xaxaZCpG/fRfg1M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q16513 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-2511350|uniprotkb:Q9H1W4|uniprotkb:D3DT24|uniprotkb:B4DQ21|uniprotkb:B4DTP5|uniprotkb:B4DVG1|uniprotkb:Q08AF4|ensembl:ENSP00000359552 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:pkn2_human(display_long)|uniprotkb:PKN2(gene name)|psi-mi:PKN2(display_short)|uniprotkb:PRK2(gene name synonym)|uniprotkb:PRKCL2(gene name synonym)|uniprotkb:Protein kinase C-like 2(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 2(gene name synonym)|uniprotkb:PKN gamma(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371386|imex:IM-22301-693 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:XP_011540074.1|refseq:NP_006247.1|refseq:NP_001307636.1|refseq:NP_001307637.1|refseq:NP_001307638.1|ensembl:ENSG00000065243(gene)|ensembl:ENST00000370521(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037784|mint:Q16513|rcsb pdb:4CRS|rcsb pdb:4RRV|rcsb pdb:6CCY|rcsb pdb:6GBE|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0032467"(positive regulation of cytokinesis)|uniprotkb:Q16513(identity)|entrezgene/locuslink:5586(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:KvHDOJ75CgHIGDC+41jGKORm2+w9606 intact-crc:F3574A8CEFC0D027|rigid:ET3KLvWhR8N3MtbjcgFSubMzwmg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16531 uniprotkb:Q8IVD9 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371405|imex:IM-22301-694 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N|uniprotkb:Q16531(identity)|ddbj/embl/genbank:BC011686(identity)|human orfeome collection:6912(identity)|entrezgene/locuslink:1642(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:55C4B330F703E412|rigid:D07L8jVUAfvW3WH4X5mFeaBQILw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q16543 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371424|imex:IM-22301-695 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:F54F47C92AAD98FF|rigid:IZMOud04RtBsx/+7eW63nHLX2r8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q6PK50 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9356629 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371443|imex:IM-22301-696 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|entrezgene/locuslink:11140(identity)|uniprotkb:Q16543(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:7251A02BF53BFD45|rigid:qdCa7mlurgjBMkIrWhXV0Bqr9oE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16671 uniprotkb:P07900 intact:EBI-6423788|ensembl:ENSP00000257863|uniprotkb:A0AVE1|uniprotkb:B9EGB7|uniprotkb:Q13762|uniprotkb:E9PGD2|uniprotkb:Q647K2|uniprotkb:F8W1D2 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:amhr2_human(display_long)|uniprotkb:AMHR2(gene name)|psi-mi:AMHR2(display_short)|uniprotkb:AMHR(gene name synonym)|uniprotkb:Anti-Muellerian hormone type II receptor(gene name synonym)|uniprotkb:MIS type II receptor(gene name synonym)|uniprotkb:MISR2(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371484|imex:IM-22301-698 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135409(gene)|ensembl:ENST00000257863(transcript)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007548"(sex differentiation)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1990262"(anti-Mullerian hormone signaling pathway)|go:"GO:1990272"(anti-Mullerian hormone receptor activity)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015771(Anti-muellerian hormone receptor, type II, C-terminal)|rcsb pdb:7L0J|reactome:R-HSA-201451|refseq:NP_001158163.1|refseq:NP_065434.1|refseq:NP_001158162.1|uniprotkb:Q16671(identity)|entrezgene/locuslink:269(identity)|human orfeome collection:54383(identity)|ddbj/embl/genbank:BC126316(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:NK97Ykth/EOUweZY2+dujr+Np8Q9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:0752123FFD84507E|rigid:itfDr1aPuJ0vODpKFRxNSEYd5vI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q16671 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-6423788|ensembl:ENSP00000257863|uniprotkb:A0AVE1|uniprotkb:B9EGB7|uniprotkb:Q13762|uniprotkb:E9PGD2|uniprotkb:Q647K2|uniprotkb:F8W1D2 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:amhr2_human(display_long)|uniprotkb:AMHR2(gene name)|psi-mi:AMHR2(display_short)|uniprotkb:AMHR(gene name synonym)|uniprotkb:Anti-Muellerian hormone type II receptor(gene name synonym)|uniprotkb:MIS type II receptor(gene name synonym)|uniprotkb:MISR2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371463|imex:IM-22301-697 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000135409(gene)|ensembl:ENST00000257863(transcript)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007548"(sex differentiation)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1990262"(anti-Mullerian hormone signaling pathway)|go:"GO:1990272"(anti-Mullerian hormone receptor activity)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015771(Anti-muellerian hormone receptor, type II, C-terminal)|rcsb pdb:7L0J|reactome:R-HSA-201451|refseq:NP_001158163.1|refseq:NP_065434.1|refseq:NP_001158162.1|uniprotkb:Q16671(identity)|entrezgene/locuslink:269(identity)|human orfeome collection:54383(identity)|ddbj/embl/genbank:BC126316(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:NK97Ykth/EOUweZY2+dujr+Np8Q9606 intact-crc:08EDBC11A5358872|rigid:ttzakOg/WBFdNkQnh7odiCjqsFA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q1JUL4 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9371508 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q1jul4_human(display_long)|uniprotkb:MC1R(gene name)|psi-mi:MC1R(display_short)|uniprotkb:Melanocortin receptor 1(gene name synonym)|uniprotkb:hCG_2039647(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371505|imex:IM-22301-699 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000761(Melanocyte-stimulating hormone receptor)|interpro:IPR001671(Melanocortin/ACTH receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_002377.4|go:"GO:0004980"(melanocyte-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043473"(pigmentation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|uniprotkb:Q1JUL4(identity)|human orfeome collection:5375(identity)|entrezgene/locuslink:10381(identity)|ddbj/embl/genbank:BC000748(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:bRaeDGsvigniM0X4LiqUDMrsmwg9606 intact-crc:D4D9F659A22AFF95|rigid:wOArxX2dd0eRvbczD7tLFV6EArI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q1JUL4 uniprotkb:Q13200 intact:EBI-9371508 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q1jul4_human(display_long)|uniprotkb:MC1R(gene name)|psi-mi:MC1R(display_short)|uniprotkb:Melanocortin receptor 1(gene name synonym)|uniprotkb:hCG_2039647(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371530|imex:IM-22301-700 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000761(Melanocyte-stimulating hormone receptor)|interpro:IPR001671(Melanocortin/ACTH receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|refseq:NP_002377.4|go:"GO:0004980"(melanocyte-stimulating hormone receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0043473"(pigmentation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|uniprotkb:Q1JUL4(identity)|human orfeome collection:5375(identity)|entrezgene/locuslink:10381(identity)|ddbj/embl/genbank:BC000748(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bRaeDGsvigniM0X4LiqUDMrsmwg9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:BEC395FDE719F277|rigid:3Rv8Yqj0NjCYt3SkBaMMEr0OnkI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q1MSW8 uniprotkb:Q15773 intact:EBI-9371555 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371552|imex:IM-22301-701 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:DF4C82BB6F956838|rigid:TCmpoRZGs9qJlneaXAEp/9H8eAk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q1MSW8 uniprotkb:Q53FC7 intact:EBI-9371555 intact:EBI-9356749 psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371578|imex:IM-22301-702 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:7683CA216E95C9D9|rigid:7W+2VHy5fIOJCSJP0Vs4H1eQGss false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q1MSW8 uniprotkb:O95816 intact:EBI-9371555 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371600|imex:IM-22301-703 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:3CC2C777FABB812A|rigid:matyWXcOGZXzv8DJu0bsKi158AU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q1MSW8 uniprotkb:Q96BE0 intact:EBI-9371555 intact:EBI-9356686 psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371644|imex:IM-22301-705 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:AA0A9C4F255E0EB5|rigid:vzA2mf0z9+6WbjtxzifLDXoUhtQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q1MSW8 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-9371555 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371622|imex:IM-22301-704 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 intact-crc:D5A934BDBAC0B0BF|rigid:HioiQkkYMBTeajbss+vBOEonzuU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q1MSW8 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9371555 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q1msw8_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371666|imex:IM-22301-706 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR040926|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0016605"(PML body)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|uniprotkb:Q1MSW8(identity)|human orfeome collection:3774(identity)|ddbj/embl/genbank:BC003596(identity)|entrezgene/locuslink:7157(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:gU4puijoL5z//jsZxqwu1QEn4e89606 intact-crc:AE2434DA0D789C12|rigid:WFQKgvnCLqZ+w9rjnTnOdhGty7Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q2EF79 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9371688 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q2ef79_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371691|imex:IM-22301-707 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|uniprotkb:Q2EF79(identity)|entrezgene/locuslink:4313(identity)|ddbj/embl/genbank:BC002576(identity)|human orfeome collection:7953(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:W3nVF3S1jZyHB/dR0hrSRY3yj5o9606 intact-crc:4F7E533B886266BF|rigid:jXP6Euc6fZMtC64SAwkbGU81c6I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q2TAC2 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2808286|ensembl:ENSP00000374292|uniprotkb:Q8IWG2|uniprotkb:A8MQC7|uniprotkb:Q8TER3|uniprotkb:A6NP51 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ccd57_human(display_long)|uniprotkb:CCDC57(gene name)|psi-mi:CCDC57(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371712|imex:IM-22301-708 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) ensembl:ENSG00000176155(gene)|ensembl:ENST00000389641(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007099"(centriole replication)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0060271"(cilium assembly)|interpro:IPR042481|refseq:NP_001303250.1|refseq:NP_932348.2|uniprotkb:Q2TAC2(identity)|entrezgene/locuslink:284001(identity)|ddbj/embl/genbank:BC040264(identity)|human orfeome collection:9378(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:YDj66sk5KcrdUoP6zw9gIxHkomg9606 intact-crc:F023B63BDDC38526|rigid:YlgzzF1sb+zyHfhYcxIMaYinxJ8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q13451 intact:EBI-9371734 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371731|imex:IM-22301-709 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:D6084A612A4DA1A8|rigid:asK5nxrgbpcbYDFrOnbp9F3Vx/w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q2TAK1 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9371734 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371754|imex:IM-22301-710 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 intact-crc:BC4480A4E18CCA86|rigid:ka+UHm98+3QbcMn9q7taUzMOi6o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q6PK50 intact:EBI-9371734 intact:EBI-9356629 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371776|imex:IM-22301-711 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:D5AC1337991A77D7|rigid:0db2umXzMsrpNo7RZnZe6++l9wo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q8IVD9 intact:EBI-9371734 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371820|imex:IM-22301-713 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:BB509BD1A254C162|rigid:7AVVXwnN3UxOLlNsIadGfza7Ybs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q2TAK1 intact:EBI-9356749 intact:EBI-9371734 psi-mi:q53fc7_human(display_long) psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371798|imex:IM-22301-712 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 intact-crc:E9A1B2565D77F11B|rigid:B24YBHzrbhI2s3ZrY4LsJFz6Zzw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:B4DYC6 intact:EBI-9371734 intact:EBI-9357028 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371839|imex:IM-22301-714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:F0B302C13A489363|rigid:VIIlZBlljHKmCI8b7cv05JZNtoc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q96BE0 intact:EBI-9371734 intact:EBI-9356686 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371859|imex:IM-22301-715 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:E98BFAB304861925|rigid:JOe7cHDohODBLTLcMA1NBfcK8vY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q9HB71 intact:EBI-9371734 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371881|imex:IM-22301-716 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:15C3CDE9986C6651|rigid:H6Eff4HVvG9OvBsA47RohW4pO6c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TAK1 uniprotkb:Q9BTE6-2 intact:EBI-9371734 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q2tak1_human(display_long)|uniprotkb:FBXO18(gene name)|psi-mi:FBXO18(display_short)|uniprotkb:hCG_24070(orf name) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371900|imex:IM-22301-717 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000212(DNA helicase, UvrD/REP type)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR014017(DNA helicase, UvrD-like, C terminal)|interpro:IPR027417|refseq:NP_001245382.1|interpro:IPR036047|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q2TAK1(identity)|ddbj/embl/genbank:BC113377(identity)|human orfeome collection:53572(identity)|entrezgene/locuslink:84893(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t5QYFZPgE0VNbQXlCBE98WPoNL89606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:B0835E23FB4D4616|rigid:nq4Qf/JycC2bgnon/2WUbjj2Tl4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:P58340 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371922|imex:IM-22301-718 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:2F657413A1C726BD|rigid:sAFOPCaGoJqKtVH1EqaqHPxjoII false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q15773 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371944|imex:IM-22301-719 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:B76F2629F7A535FE|rigid:roWrrATsYOGnBcJRYwtXE2LT0WY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q6PK50 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-9356629 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371966|imex:IM-22301-720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:5C52A45CCE5F905C|rigid:/YVr5klZnAG6sNmUtxTg4HXpcck false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q8IVD9 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9371988|imex:IM-22301-721 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:F60A2DAF64431256|rigid:lL7g1KuPmjdzKnamKXKRE+hvlQs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:B4DYC6 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-9357028 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372007|imex:IM-22301-722 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:CC6281E90D13D0CB|rigid:vuDvH5MD6oEAg+HYW3zJkBVFpSE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:O43765 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372027|imex:IM-22301-723 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:89EC276923A38CDC|rigid:VkWGByZ1nFOL6tJb6hafA8VSKrc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q96BE0 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-9356686 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372049|imex:IM-22301-724 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:65F9B58AA6A06DD8|rigid:Zb1uhoYsd8DPFVy3pXxqqY6WTdY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:P07900 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372071|imex:IM-22301-725 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:E17E557D737807FD|rigid:oDFTUhzXSFP3SAjOfsuFfH+i+Wo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:P31948 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372092|imex:IM-22301-726 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:2062C4AB97E4BDCF|rigid:UnOCIGNeaaUE60g95oy/CmJIxc0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q9UNE7 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372111|imex:IM-22301-727 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:5A72D7E7580DA70C|rigid:Z3iUnQ+7Em5XAYjhPQ6ZBG1E6ok false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q9HB71 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372133|imex:IM-22301-728 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:9AE08FC308358ADC|rigid:UELvvPUOK3916jg9uxFuUWyfFdM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q9BTE6-2 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372152|imex:IM-22301-729 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:3E83CB30DF8C2CFF|rigid:eQnEUoh9vYiXg5ELJBmdZGJBWd0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:B3KTT5 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-8783896 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:b3ktt5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372174|imex:IM-22301-730 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886(identity)|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 intact-crc:34D266962C2FF5D8|rigid:IRY8QVMnhIw15zvV9LRjJ2NiR3A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q308M6 intact:EBI-9356686 intact:EBI-9372199 psi-mi:q96be0_human(display_long) psi-mi:q308m6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372196|imex:IM-22301-731 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR042087|refseq:NP_001295561.1|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR036397|interpro:IPR043502|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|uniprotkb:Q308M6(identity)|human orfeome collection:4775(identity)|ddbj/embl/genbank:BC008800(identity)|entrezgene/locuslink:5424(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ezZMT28irhNgcT9eWGA6i+KtgxA9606 intact-crc:3A138A029C3F4546|rigid:eN2hMpphk3qLdVRt2FO8ueFURQw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q308M6 uniprotkb:P31948 intact:EBI-9372199 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q308m6_human(display_long) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372222|imex:IM-22301-732 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042087|refseq:NP_001295561.1|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR036397|interpro:IPR043502|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|uniprotkb:Q308M6(identity)|human orfeome collection:4775(identity)|ddbj/embl/genbank:BC008800(identity)|entrezgene/locuslink:5424(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezZMT28irhNgcT9eWGA6i+KtgxA9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:F007AAFE51CB52E8|rigid:olRZMXZ6LEslSglGYjy9o9NDpx8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q308M6 uniprotkb:O00170 intact:EBI-9372199 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:q308m6_human(display_long) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372241|imex:IM-22301-733 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042087|refseq:NP_001295561.1|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR036397|interpro:IPR043502|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|uniprotkb:Q308M6(identity)|human orfeome collection:4775(identity)|ddbj/embl/genbank:BC008800(identity)|entrezgene/locuslink:5424(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezZMT28irhNgcT9eWGA6i+KtgxA9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:607A7EF1B4F2870B|rigid:sU3GupjNfov/vOE+7RYTDXc07RQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q308M6 uniprotkb:Q9BTE6-2 intact:EBI-9372199 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q308m6_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372260|imex:IM-22301-734 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR042087|refseq:NP_001295561.1|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017964|interpro:IPR025687|interpro:IPR036397|interpro:IPR043502|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|uniprotkb:Q308M6(identity)|human orfeome collection:4775(identity)|ddbj/embl/genbank:BC008800(identity)|entrezgene/locuslink:5424(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezZMT28irhNgcT9eWGA6i+KtgxA9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:382FE68CBD523470|rigid:jOYcrQb7tgYXYhGgVjQViFYirR0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q3KQR5 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9372282 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372286|imex:IM-22301-735 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 intact-crc:BB247095CBC304DD|rigid:0IJcCEHPwMzqOW+IVV9C8aF6uGs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3KQR5 uniprotkb:B4DYC6 intact:EBI-9372282 intact:EBI-9357028 psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372305|imex:IM-22301-736 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:3C850BD7ACEB680B|rigid:4Wy5VEAm0zBtCUgUBuyRED7/fwU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3KQR5 uniprotkb:Q6PK50 intact:EBI-9372282 intact:EBI-9356629 psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372325|imex:IM-22301-737 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:842F94F1F4119FAA|rigid:ML57zeHsuwu2jOn3/1ZKPoNKv5M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3KQR5 uniprotkb:Q16543 intact:EBI-9372282 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372347|imex:IM-22301-738 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:BCD6C4815EEC46E8|rigid:WImudgjLpHeVcFB2ZiPJ9/4zmY8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3KQR5 uniprotkb:Q9HB71 intact:EBI-9372282 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372367|imex:IM-22301-739 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:B0E1A467F4596CE3|rigid:D9MRWhCPPBv+bs0Sq/KFNN6cXV0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q3KQR5 intact:EBI-9356686 intact:EBI-9372282 psi-mi:q96be0_human(display_long) psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372386|imex:IM-22301-740 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 intact-crc:E777D98A2584EA4E|rigid:UhdtQKfBRMYZLfcZXatRm55/bss false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3KQR5 uniprotkb:Q9BPW0 intact:EBI-9372282 intact:EBI-9356778 psi-mi:q3kqr5_human(display_long)|uniprotkb:C20orf194(gene name)|psi-mi:C20orf194(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372408|imex:IM-22301-741 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR040342|uniprotkb:Q3KQR5(identity)|human orfeome collection:55926(identity)|ddbj/embl/genbank:BC122529(identity)|entrezgene/locuslink:25943(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity)|uniprotkb:Q9BPW0(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QAqwiETKJWQ8Onai2/EMR5d9hs9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:11184DDBA9B38865|rigid:0ycionMUxx2VNcqsBrFdvOKAxzc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q3MSN4 intact:EBI-9356749 intact:EBI-9372430|ensembl:ENSP00000420856|ensembl:ENSP00000424747|ensembl:ENSP00000425313|ensembl:ENSP00000426478 psi-mi:q53fc7_human(display_long) psi-mi:q3msn4_human(display_long)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372434|imex:IM-22301-742 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000113580(gene)|ensembl:ENST00000502892(transcript)|ensembl:ENST00000508760(transcript)|ensembl:ENST00000510170(transcript)|ensembl:ENST00000514699(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR001409(Glucocorticoid receptor)|uniprotkb:Q3MSN4(identity)|human orfeome collection:7587(identity)|ddbj/embl/genbank:BC015610(identity)|entrezgene/locuslink:2908(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:imFCN48AqqmvNo5MGQG+b6vAyVU9606 intact-crc:F6BDF0852AC08657|rigid:jyzLjwzzrRDOdvcPSAqPcfZnMFk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q13451 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372478|imex:IM-22301-744 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:2CAA7DD0F68402C7|rigid:SJnVr+k1B9FyOr+rfolSBEPGN1E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3MSN4 uniprotkb:Q96BE0 intact:EBI-9372430|ensembl:ENSP00000420856|ensembl:ENSP00000424747|ensembl:ENSP00000425313|ensembl:ENSP00000426478 intact:EBI-9356686 psi-mi:q3msn4_human(display_long)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372456|imex:IM-22301-743 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000113580(gene)|ensembl:ENST00000502892(transcript)|ensembl:ENST00000508760(transcript)|ensembl:ENST00000510170(transcript)|ensembl:ENST00000514699(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR001409(Glucocorticoid receptor)|uniprotkb:Q3MSN4(identity)|human orfeome collection:7587(identity)|ddbj/embl/genbank:BC015610(identity)|entrezgene/locuslink:2908(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:imFCN48AqqmvNo5MGQG+b6vAyVU9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:4580276C896C220F|rigid:sfw+l+iat591ppfduqNDan3lxug false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q6PK50 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-9356629 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372497|imex:IM-22301-745 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:348AD44E09934E4E|rigid:GBT0EPMpLlkSTVzWqhKapfY5WeY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q03933 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372519|imex:IM-22301-746 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:CE8212F1E3155AAD|rigid:ycQhi+1YqZ/R09VR1LbVhTSMvC8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q99933 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372538|imex:IM-22301-747 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:C2B08FE11B7029A5|rigid:LgT5n4wlnWv4/ir/UlWz0T/fe9E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q9UNE7 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372582|imex:IM-22301-749 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:CB36A9BE54BE87CC|rigid:5RZfVY4TcqQvU4MfBqe0HeR21RQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:O75344 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372560|imex:IM-22301-748 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 intact-crc:5EB1FB8C3E4172E9|rigid:KIhnmHMZeB2C1reRd78Gd+/xSxk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q9BTE6-2 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372604|imex:IM-22301-750 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:89814E35A309BB46|rigid:gS1iTy5SlCB6vJwCf1wqX+RUyIg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:Q13451 intact:EBI-9372651 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372648|imex:IM-22301-752 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:4520F81254BB5AA7|rigid:gaCaYW+hi4bda8+HKji+b6PSSHk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYB3 uniprotkb:Q9BPW0 intact:EBI-6425864|ensembl:ENSP00000484875|uniprotkb:B2RPC4|uniprotkb:Q4V336 intact:EBI-9356778 psi-mi:fx4l6_human(display_long)|uniprotkb:FOXD4L6(gene name)|psi-mi:FOXD4L6(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372626|imex:IM-22301-751 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000273514(gene)|ensembl:ENST00000622588(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|refseq:NP_001078945.1|uniprotkb:Q3SYB3(identity)|ddbj/embl/genbank:BC103887(identity)|entrezgene/locuslink:653404(identity)|human orfeome collection:52817(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WORhNqs8vOXNc5eM2civM28LqbQ9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:9C37CA5314F43AC6|rigid:utIgyHXwvm9I+C11Og0/wCcqx/E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:Q6PK50 intact:EBI-9372651 intact:EBI-9356629 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372692|imex:IM-22301-754 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:F48AD4BF26D1BBDA|rigid:34139I3rUtK+N05/VaWc3WTQh9U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q3SYG0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9372651 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372671|imex:IM-22301-753 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 intact-crc:6A8A76D0977F225F|rigid:uH9D7g9wURIKD/AURdy50ffLwOY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:Q9Y266 intact:EBI-9372651 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372714|imex:IM-22301-755 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:D02872FCF240095C|rigid:Eannj/dDMMG7eitJe+nwRJpIRX8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q3SYG0 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9372651 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372755|imex:IM-22301-757 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 intact-crc:1AA2D0A0AE12F578|rigid:2wCauqIyDEQA9hcxGBBg6edONPM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q3SYG0 intact:EBI-9357141 intact:EBI-9372651 psi-mi:q9hav2_human(display_long) psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372733|imex:IM-22301-756 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 intact-crc:42D07EBECB9E4AB2|rigid:6YM07kOcpnzQy+VD80Saarv5+tE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:O43765 intact:EBI-9372651 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372774|imex:IM-22301-758 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:45C71942A52037CA|rigid:0Us6Kdvgw9EFMhJt4Hymu/4K7JA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q3SYG0 intact:EBI-9356686 intact:EBI-9372651 psi-mi:q96be0_human(display_long) psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372796|imex:IM-22301-759 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 intact-crc:C8AD3D3BB882D528|rigid:zJhh+eeuIPNeHOYeIXv0bAU9x2M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:P31948 intact:EBI-9372651 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372818|imex:IM-22301-760 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:9E21E09AAA2A8012|rigid:29kP+aBCy4NmkGor02ZbXcJyIxM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q3SYG0 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9372651 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372837|imex:IM-22301-761 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 intact-crc:31EF600C5457C657|rigid:o6wovbeoomk8MuLx/CYaAIbH2TM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYG0 uniprotkb:Q8WVJ2 intact:EBI-9372651 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:q3syg0_human(display_long)|uniprotkb:PRDM1(gene name)|psi-mi:PRDM1(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372859|imex:IM-22301-762 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001214(SET)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR016608(PR-domain zinc finger protein PRDM1)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046872"(metal ion binding)|uniprotkb:Q3SYG0(identity)|ddbj/embl/genbank:BC103832(identity)|entrezgene/locuslink:639(identity)|human orfeome collection:52831(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:26XSa2yqkZ6HTOX2QpB0HY2AbSA9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:BFECC8AFADC84462|rigid:vIYRD/MxUul/S+km7v+Q2oSHGyY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q3UJD6-1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372899|imex:IM-22301-764 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:A6D3856B0DC4DD11|rigid:a5yXufHte3UQd15cMwZYtQtgrOs false renilla luciferase protein tag:c-c("MI:0896") flag tag:n-n("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q9BTE6-2 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372878|imex:IM-22301-763 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:086B2DC81C4C4550|rigid:BIexXZ+yBHr+VZebs1Uuz3zzuRI false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q3UJD6-2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372919|imex:IM-22301-765 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:2FCE62DC17F855B7|rigid:31cByqKJwY+nXkDC1wNatFgdqVE false renilla luciferase protein tag:c-c("MI:0896") flag tag:n-n("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q4G1B2 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9372961 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372965|imex:IM-22301-767 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 intact-crc:CBC45852AADDB667|rigid:KZDEP+MpQcfS+wy5jwSM50MyjK0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-2 uniprotkb:O75344 intact:EBI-9359023|ensembl:ENSMUSP00000082119 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372940|imex:IM-22301-766 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 intact-crc:B79F6AFCFC639532|rigid:suGOGovKW1wM1JJTwSVoNYs8NiU false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4G1B2 uniprotkb:Q6PK50 intact:EBI-9372961 intact:EBI-9356629 psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9372987|imex:IM-22301-768 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:9F0B831E0A13B626|rigid:3ISbrSoXo7r+ALFSqLtEVZr6BN4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4G1B2 uniprotkb:Q8IVD9 intact:EBI-9372961 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373009|imex:IM-22301-769 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:FCCB2781EFA9FFD5|rigid:sQGDSSWtJQqNWA6YIsx58z4kUqo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4G1B2 uniprotkb:Q13200 intact:EBI-9372961 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373028|imex:IM-22301-770 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:E19CA1CF0EE2DA77|rigid:Ph0X5SKb62g/hxK0Ri5WJhgr4DU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75344 uniprotkb:Q4G1B2 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-9372961 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373050|imex:IM-22301-771 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 intact-crc:9B073942573C0BA4|rigid:LoKWFa3mRWvTGWV8Jl8sYTxfqJY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q4G1B2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9372961 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q4g1b2_human(display_long)|uniprotkb:RGS9(gene name)|psi-mi:RGS9(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373072|imex:IM-22301-772 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4G1B2(identity)|human orfeome collection:71331(identity)|ddbj/embl/genbank:BC022504(identity)|entrezgene/locuslink:8787(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:G0nb7GSC5/3Vjutz7ZPvZT+8OhQ9606 intact-crc:080BA01E8A907D7A|rigid:4J6C3xUh6ODSxyx8KZxxxhSWFew false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q13451 intact:EBI-9373097 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373094|imex:IM-22301-773 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:63BA95A017D67D30|rigid:LPab92iWwxJBEJXH5TAxrGtZ2/o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q4TT70 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9373097 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373117|imex:IM-22301-774 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 intact-crc:D968D440F2DDD3B8|rigid:xTZdMDglF8nxszUN9PmcKiiPWW0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q4TT70 intact:EBI-9356629 intact:EBI-9373097 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373138|imex:IM-22301-775 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 intact-crc:DF53EE18FA3D14FC|rigid:iPM+IQZ8S38+O4ELnizMHKFs5M0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q4TT70 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9373097 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373182|imex:IM-22301-777 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 intact-crc:7CFD162C37CF4D59|rigid:6YXc/wXOYan718l0TsK4XVCbOnU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q53FC7 intact:EBI-9373097 intact:EBI-9356749 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373160|imex:IM-22301-776 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:6B5FA254ED045277|rigid:WPcfEcXxd65AMX3vZFJUExBLmPw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q4TT70 intact:EBI-9357028 intact:EBI-9373097 psi-mi:b4dyc6_human(display_long) psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373201|imex:IM-22301-778 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 intact-crc:4C94B8C2D7C300B4|rigid:nd5f4Dqc8m9thl1xIsrgo/hVbQo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q96BE0 intact:EBI-9373097 intact:EBI-9356686 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373243|imex:IM-22301-780 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:E374079C67A17A0E|rigid:JlDmLEijnh8T9lvQTxiF1oT3Gu8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q13200 intact:EBI-9373097 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373221|imex:IM-22301-779 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:7031F006576C3929|rigid:Qwh76ew2tlfkYjpBHsQiOKNZp9U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q4TT70 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9373097 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373265|imex:IM-22301-781 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 intact-crc:50BDFDF76B7DF272|rigid:c3lsDdzNdEKHDIT0phI9cYwrIfI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q9HB71 intact:EBI-9373097 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373285|imex:IM-22301-782 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:30F6CBABAF3D5A70|rigid:PaI4KEkARszBvT/O17PU+oarJps false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q4TT70 uniprotkb:Q9BTE6-2 intact:EBI-9373097 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q4tt70_human(display_long)|uniprotkb:RGS11(gene name)|psi-mi:RGS11(display_short)|uniprotkb:AC004754.2-001(orf name)|uniprotkb:hCG_1984117(orf name) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373304|imex:IM-22301-783 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR016137(Regulator of G protein signalling superfamily)|refseq:NP_899180.1|interpro:IPR040759|interpro:IPR036284|interpro:IPR036305|interpro:IPR036388|interpro:IPR036390|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0035556"(intracellular signal transduction)|uniprotkb:Q4TT70(identity)|human orfeome collection:55659(identity)|ddbj/embl/genbank:BC141803(identity)|entrezgene/locuslink:8786(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l36L7EvTd6ELLrkI2BiGLu/Fg2A9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:E235A2BE0736F0A3|rigid:ahxq9n5MdFh/Tz06Si4faaA7rLs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53F65 uniprotkb:Q13451 intact:EBI-9373326 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q53f65_human(display_long) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373329|imex:IM-22301-784 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036388|interpro:IPR036390|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|uniprotkb:Q53F65(identity)|entrezgene/locuslink:51513(identity)|human orfeome collection:10161(identity)|ddbj/embl/genbank:BC035853(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CGqaMJmLEZTUP5FrhUiMYfsyeNk9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:66FC9A8E45EEE824|rigid:1fRpOPWNyPFdJHok6D515fh4bGY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:Q53FC7 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-9356749 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373348|imex:IM-22301-785 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:1E1F806CF5129BB3|rigid:rqsonoZb6v55W3vRWlnyP0jQniY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q53FC7 intact:EBI-9357141 intact:EBI-9356749 psi-mi:q9hav2_human(display_long) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373370|imex:IM-22301-786 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:BCE126346FC38EB3|rigid:WvJu5BIqr8rWFU2TBIS2Pfdk1aA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q53FC7 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9356749 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373392|imex:IM-22301-787 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:3827276FA638DB86|rigid:cURjw8jtyNzgCyBAHefxiI+8+50 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q9UL15 intact:EBI-9356749 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:q53fc7_human(display_long) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373436|imex:IM-22301-789 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|human orfeome collection:11688(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 intact-crc:9ADBBBE10C3F14A9|rigid:FuV+C4u0FO9CrwjBcMwCk/4SURk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q99933 intact:EBI-9356749 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:q53fc7_human(display_long) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373414|imex:IM-22301-788 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:77245280B7E10B4D|rigid:B3jJuxN5pPxlTOh5MqIhWqCqTgo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q99471 intact:EBI-9356749 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:q53fc7_human(display_long) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373458|imex:IM-22301-790 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:FC7F246FCA2BF60E|rigid:EifGMq8si+8H0/bfr9HwdchC4Ic false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q53FC7 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9356749 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373477|imex:IM-22301-791 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:CDA0730075DD3278|rigid:h8rtftdJUfz9rlnahWtg97Ubgz8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53G71 uniprotkb:Q16543 intact:EBI-9373499 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q53g71_human(display_long) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373502|imex:IM-22301-792 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|go:"GO:0005509"(calcium ion binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|ddbj/embl/genbank:BC002500(identity)|human orfeome collection:119(identity)|uniprotkb:Q53G71(identity)|entrezgene/locuslink:811(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1BwWKX3adpk7IFUTGy+Yl0EwI/M9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:9F6E06C830259D2F|rigid:PDfIILbySDil6+6l2/FdL88aYQ8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53G83 uniprotkb:O00170 intact:EBI-9373522 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:q53g83_human(display_long) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373525|imex:IM-22301-793 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001351(Ribosomal protein S3, C-terminal)|interpro:IPR004044(K Homology, type 2)|interpro:IPR005703(Ribosomal protein S3, eukaryotic/archaeal)|interpro:IPR009019(K Homology, prokaryotic type)|interpro:IPR015946(K homology-like, alpha/beta)|interpro:IPR018280|interpro:IPR036419|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005819"(spindle)|go:"GO:0006281"(DNA repair)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0051301"(cell division)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|uniprotkb:Q53G83(identity)|ddbj/embl/genbank:BC003137(identity)|entrezgene/locuslink:6188(identity)|human orfeome collection:3880(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YFzsiKVAKnnIT1zndT6eD3btGhs9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:9CD661953826213C|rigid:0n0xLIcMAHdplqkaOTI69RC/vwE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q53HB3 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9362707 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q53hb3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373544|imex:IM-22301-794 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR035244|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|uniprotkb:Q53HB3(identity)|ddbj/embl/genbank:BC000512(identity)|entrezgene/locuslink:5700(identity)|human orfeome collection:4018(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:Unfk3E8DIsBKU/b5AIjm4wDR26M9606 intact-crc:0C7327EAF77C389D|rigid:Pbtj3vbh+IaJ5/sIbEHc6Rj3olI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HC9 uniprotkb:P58340 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373566|imex:IM-22301-795 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:181721064C9D8792|rigid:pjvOE8grUWnSftGzkABDAa9eWoQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HC9 uniprotkb:Q15773 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373588|imex:IM-22301-796 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:035CAD01C51B5B55|rigid:uJvy7UpgEb5w2++xcNSj2OFci1c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HC9 uniprotkb:Q6PK50 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 intact:EBI-9356629 psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373610|imex:IM-22301-797 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:DB83F06EDECB2BBE|rigid:JGg9YA+iRAaC6S+AtnaB/rcSY6c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HC9 uniprotkb:Q9Y266 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373632|imex:IM-22301-798 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:145F93DBD31ACDCD|rigid:64GngqIRelj0BTdlDxAwqcDIQcA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q53HC9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373651|imex:IM-22301-799 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:CF8F4333282B02C9|rigid:vZB059l7MEm7XhueGNhbdjNY9bs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q53HC9 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373670|imex:IM-22301-800 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:029BE1393083521A|rigid:o6TsA7ieN3BG17p74QdySrEZiTQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q53HC9 intact:EBI-9356686 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:q96be0_human(display_long) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373692|imex:IM-22301-801 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:4EC9AA8544F95F6C|rigid:HSkZgGu6pMdfCQnRoNf/fSKgYGA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q53HC9 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373714|imex:IM-22301-802 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:1EBF8C31F29AFD05|rigid:5IVmtRc2bWHMECXiNxhHGnuz3dg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q53HC9 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373733|imex:IM-22301-803 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:3A70F751E5065B04|rigid:VZgMUJyNYykqdgtJYamMyl8sETs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q53HC9 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373755|imex:IM-22301-804 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:62592BD619F251F7|rigid:gqa2nKbIyAacBUPy1jKKqTXY5EM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q53HC9 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373774|imex:IM-22301-805 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:1C8CF03DE21CEC29|rigid:ZKTX7QDTiEmJ/DcxU1llFwaNYBc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q53HC9 intact:EBI-9356778 intact:EBI-1055422|uniprotkb:O43179|uniprotkb:Q53S19|uniprotkb:Q53SG2|uniprotkb:D6W4Y1|ensembl:ENSP00000371559 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:eipr1_human(display_long)|uniprotkb:Golgi-associated retrograde protein-interacting protein(gene name synonym)|uniprotkb:EIPR1(gene name)|psi-mi:EIPR1(display_short)|uniprotkb:Endosome-associated recycling protein-interacting protein(gene name synonym)|uniprotkb:TSSC1(gene name synonym)|uniprotkb:Tumor-suppressing STF cDNA 1 protein(gene name synonym)|uniprotkb:Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373796|imex:IM-22301-806 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_003301.1|ensembl:ENSG00000032389(gene)|ensembl:ENST00000382125(transcript)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032456"(endocytic recycling)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:2001137"(positive regulation of endocytic recycling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR040323|go:"GO:0005802"(trans-Golgi network)|uniprotkb:Q53HC9(identity)|human orfeome collection:3265(identity)|ddbj/embl/genbank:BC002485(identity)|entrezgene/locuslink:7260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:aPOAhiHUITd/B039ctxriPOgfeU9606 intact-crc:9F838D5737CFD08B|rigid:/44PBu+PHkq8WNS0U+vjzIMxREc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q53HY9 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9373821 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373818|imex:IM-22301-807 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 intact-crc:7158CDE2A9B6932E|rigid:LUGFU5k5F9UEAx8TXG8RiatAzQ0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HY9 uniprotkb:Q6PK50 intact:EBI-9373821 intact:EBI-9356629 psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373841|imex:IM-22301-808 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:00EE46B292AFEDFE|rigid:I6RgM/glJAAjaRmq3SfjOyPLYtw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q53HY9 intact:EBI-9356686 intact:EBI-9373821 psi-mi:q96be0_human(display_long) psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373863|imex:IM-22301-809 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 intact-crc:3CC9AF360F33830C|rigid:PJdDOfzEryEn+vRjefdreoHpee4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HY9 uniprotkb:P31948 intact:EBI-9373821 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373885|imex:IM-22301-810 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:E16BEA6DFEA47DCC|rigid:NucWpFBSP/+lCJWn3w0h4wnW+7A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HY9 uniprotkb:Q16543 intact:EBI-9373821 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373904|imex:IM-22301-811 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:714FE88E3153B1FF|rigid:2gDMLR59qlyqge1/o7wpPZn7CMo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53SM6 uniprotkb:O00170 intact:EBI-9373946 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:q53sm6_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373950|imex:IM-22301-813 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR013655(PAS fold-3)|interpro:IPR035965|interpro:IPR036638|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0046983"(protein dimerization activity)|uniprotkb:Q53SM6(identity)|entrezgene/locuslink:2034(identity)|ddbj/embl/genbank:BC051338(identity)|human orfeome collection:13650(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ak5vfDgB08DMoMrbjodMTeDsKXY9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:F58261313B44A7CF|rigid:RiGUyEyNr7QORG7hA9Y1LQVa7H0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HY9 uniprotkb:Q9BPW0 intact:EBI-9373821 intact:EBI-9356778 psi-mi:q53hy9_human(display_long)|uniprotkb:PADI4(gene name)|psi-mi:PADI4(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373924|imex:IM-22301-812 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR004303(Protein-arginine deiminase)|interpro:IPR008972(Cupredoxin)|interpro:IPR013732("Protein-arginine deiminase (PAD) N-terminal")|interpro:IPR038685|go:"GO:0004668"(protein-arginine deiminase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0018101"(protein citrullination)|uniprotkb:Q53HY9(identity)|ddbj/embl/genbank:BC025718(identity)|human orfeome collection:8383(identity)|entrezgene/locuslink:23569(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LE9zFnMxh55ImalPUWQcS1Cj/fE9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:C3953D0E7E8AFDD1|rigid:NvkTZ9CXkQVidboEX001lnB9PS0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q53XS2 intact:EBI-9356629 intact:EBI-9373969 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q53xs2_human(display_long)|uniprotkb:ENC1(gene name)|psi-mi:ENC1(display_short)|uniprotkb:hCG_37104(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373973|imex:IM-22301-814 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR030562|refseq:XP_011541998.1|refseq:XP_011541999.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001243503.1|refseq:NP_001243504.1|refseq:NP_001243505.1|refseq:NP_003624.1|go:"GO:0000785"(chromatin)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0043025"(neuronal cell body)|uniprotkb:Q53XS2(identity)|ddbj/embl/genbank:BC000418(identity)|human orfeome collection:4705(identity)|entrezgene/locuslink:8507(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:iYVAJB18JYnkEtcXIabPaMwVVDc9606 intact-crc:9B83F21B4D931B35|rigid:aFqf7xxVqipPwjgKg0sXN0pBEpg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q53XS2 intact:EBI-9356749 intact:EBI-9373969 psi-mi:q53fc7_human(display_long) psi-mi:q53xs2_human(display_long)|uniprotkb:ENC1(gene name)|psi-mi:ENC1(display_short)|uniprotkb:hCG_37104(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9373995|imex:IM-22301-815 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) interpro:IPR030562|refseq:XP_011541998.1|refseq:XP_011541999.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001243503.1|refseq:NP_001243504.1|refseq:NP_001243505.1|refseq:NP_003624.1|go:"GO:0000785"(chromatin)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0043025"(neuronal cell body)|uniprotkb:Q53XS2(identity)|ddbj/embl/genbank:BC000418(identity)|human orfeome collection:4705(identity)|entrezgene/locuslink:8507(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:iYVAJB18JYnkEtcXIabPaMwVVDc9606 intact-crc:E88DEDD1BC0D2652|rigid:wr/Iwfyv9ebd/guq5inlnPq2I7Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53XS2 uniprotkb:Q8IVD9 intact:EBI-9373969 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q53xs2_human(display_long)|uniprotkb:ENC1(gene name)|psi-mi:ENC1(display_short)|uniprotkb:hCG_37104(orf name) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374017|imex:IM-22301-816 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030562|refseq:XP_011541998.1|refseq:XP_011541999.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001243503.1|refseq:NP_001243504.1|refseq:NP_001243505.1|refseq:NP_003624.1|go:"GO:0000785"(chromatin)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0043025"(neuronal cell body)|uniprotkb:Q53XS2(identity)|ddbj/embl/genbank:BC000418(identity)|human orfeome collection:4705(identity)|entrezgene/locuslink:8507(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iYVAJB18JYnkEtcXIabPaMwVVDc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:00EE5B5F49D28282|rigid:Gad/WJHZWD9mkUUr+f362+1TJkg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53XS2 uniprotkb:Q96BE0 intact:EBI-9373969 intact:EBI-9356686 psi-mi:q53xs2_human(display_long)|uniprotkb:ENC1(gene name)|psi-mi:ENC1(display_short)|uniprotkb:hCG_37104(orf name) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374036|imex:IM-22301-817 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030562|refseq:XP_011541998.1|refseq:XP_011541999.1|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001243503.1|refseq:NP_001243504.1|refseq:NP_001243505.1|refseq:NP_003624.1|go:"GO:0000785"(chromatin)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0007399"(nervous system development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0043025"(neuronal cell body)|uniprotkb:Q53XS2(identity)|ddbj/embl/genbank:BC000418(identity)|human orfeome collection:4705(identity)|entrezgene/locuslink:8507(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iYVAJB18JYnkEtcXIabPaMwVVDc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:A7A41B9FD00F75C7|rigid:6mRn2FUNmhlW74JVHmAI7jA25Zc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q573B4 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9374061|ensembl:ENSP00000362665 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374058|imex:IM-22301-818 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 intact-crc:E4916778284C140E|rigid:CQc89F8/Uyt363NTkwu+rR6lD3s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q573B4 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9374061|ensembl:ENSP00000362665 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374084|imex:IM-22301-819 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 intact-crc:9716A3D272A3E279|rigid:sAY/2JcGlR5JxUgpWj2cUAxqry4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q573B4 intact:EBI-9356629 intact:EBI-9374061|ensembl:ENSP00000362665 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374105|imex:IM-22301-820 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 intact-crc:8CF12893C27E16DE|rigid:Bd564qlgCCDM6C5zxvWsPElm0rI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q573B4 intact:EBI-9356686 intact:EBI-9374061|ensembl:ENSP00000362665 psi-mi:q96be0_human(display_long) psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374127|imex:IM-22301-821 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 intact-crc:31C4CD151181B658|rigid:xzn7qAmW+B43LgYi46lvdC1cRX8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q573B4 uniprotkb:Q16543 intact:EBI-9374061|ensembl:ENSP00000362665 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374170|imex:IM-22301-823 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:CAD32231E2FE875D|rigid:9G+I97OACWEHfnWkfYS4F1UmNr4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q573B4 uniprotkb:P07900 intact:EBI-9374061|ensembl:ENSP00000362665 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374149|imex:IM-22301-822 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:B6FAF28B3005FD60|rigid:U2TvfiTZ8/oFhzB7ibHY8OH9xvE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q573B4 uniprotkb:Q9BPW0 intact:EBI-9374061|ensembl:ENSP00000362665 intact:EBI-9356778 psi-mi:q573b4_human(display_long)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374190|imex:IM-22301-824 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011539755.1|refseq:XP_011539756.1|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|interpro:IPR001452(Src homology-3)|ensembl:ENSG00000182866(gene)|ensembl:ENST00000373564(transcript)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|uniprotkb:Q573B4(identity)|human orfeome collection:966(identity)|ddbj/embl/genbank:BC013200(identity)|entrezgene/locuslink:3932(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:sbDU3pOHjGqo9ih7E0t6rJPA15w9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:4EA8D13D51899AC2|rigid:siSVOAEsUtMOtMV/RCaEuY5SUPU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92598 uniprotkb:Q59E89 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 intact:EBI-9374215 psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:q59e89_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374212|imex:IM-22301-825 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453|uniprotkb:Q92598(identity)|ddbj/embl/genbank:BC037553(identity)|entrezgene/locuslink:10808(identity)|human orfeome collection:9615(identity) interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q59E89(identity)|human orfeome collection:2567(identity)|entrezgene/locuslink:11080(identity)|ddbj/embl/genbank:BC034721(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 rogid:sCWjDtWlVDTvLVBRywAsiQTBXJg9606 intact-crc:63312CDD58EBB6C6|rigid:8pclvCMtGD48UYYFOhWVNghES9Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FJ7 uniprotkb:Q96BE0 intact:EBI-7671334|intact:MINT-6177403 intact:EBI-9356686 psi-mi:q59fj7_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374237|imex:IM-22301-826 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q59FJ7|interpro:IPR030509|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q59FJ7(identity)|human orfeome collection:3787(identity)|entrezgene/locuslink:1453(identity)|ddbj/embl/genbank:BC003558(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) comment:"fragmentation type: fragment"|comment:mint - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AJa2S8WcNFurm+BQ3ljnovlH57U9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:FA534D364948216B|rigid:I+L5mlTLh0E4rTD+To9LAA7UpYw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FJ7 uniprotkb:Q16543 intact:EBI-7671334|intact:MINT-6177403 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q59fj7_human(display_long) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374259|imex:IM-22301-827 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q59FJ7|interpro:IPR030509|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q59FJ7(identity)|human orfeome collection:3787(identity)|entrezgene/locuslink:1453(identity)|ddbj/embl/genbank:BC003558(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) comment:"fragmentation type: fragment"|comment:mint - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AJa2S8WcNFurm+BQ3ljnovlH57U9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:3F97CBF3F76CC1A0|rigid:Zh4Ivch4L5H+bL4tIuFy3LDJpX4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FJ7 uniprotkb:Q9BTE6-2 intact:EBI-7671334|intact:MINT-6177403 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q59fj7_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374279|imex:IM-22301-828 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:Q59FJ7|interpro:IPR030509|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q59FJ7(identity)|human orfeome collection:3787(identity)|entrezgene/locuslink:1453(identity)|ddbj/embl/genbank:BC003558(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) comment:"fragmentation type: fragment"|comment:mint isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AJa2S8WcNFurm+BQ3ljnovlH57U9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:EFC3D73B74FD62A5|rigid:ba8+ahZPpVVH9WUBEh1sfWpwBu4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FM5 uniprotkb:P58340 intact:EBI-9374304 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q59fm5_human(display_long) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374301|imex:IM-22301-829 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0045202"(synapse)|uniprotkb:Q59FM5(identity)|ddbj/embl/genbank:BC096225(identity)|entrezgene/locuslink:2767(identity)|human orfeome collection:55802(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:0jlrbMxwLYypZoRevdMbJ/FwmUw9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:204D5A26772C275A|rigid:RWn8TWDkUyR67qyZBjHLOpOW14M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q59FM5 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9374304 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q59fm5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374326|imex:IM-22301-830 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0045202"(synapse)|uniprotkb:Q59FM5(identity)|ddbj/embl/genbank:BC096225(identity)|entrezgene/locuslink:2767(identity)|human orfeome collection:55802(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:0jlrbMxwLYypZoRevdMbJ/FwmUw9606 intact-crc:B7798BD39D38E9C2|rigid:jy0b47yizZ5wR8jQUv7Uvc6vMjY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q59FM5 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9374304 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q59fm5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374348|imex:IM-22301-831 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0045202"(synapse)|uniprotkb:Q59FM5(identity)|ddbj/embl/genbank:BC096225(identity)|entrezgene/locuslink:2767(identity)|human orfeome collection:55802(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:0jlrbMxwLYypZoRevdMbJ/FwmUw9606 intact-crc:EE6A3157BB1FA1FD|rigid:e1OGlHS2YOa3t9BWijqaXaGWlDo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FP4 uniprotkb:Q13451 intact:EBI-9374370 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q59fp4_human(display_long) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374373|imex:IM-22301-832 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:1EA327882F2D3B6B|rigid:Vz8nx/LnzKTakrjRq+Kvjj9DuTM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q59FP4 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9374370 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q59fp4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374392|imex:IM-22301-833 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 intact-crc:DD68FBA63D6AB609|rigid:dJZ9WOYzI8+jw0m0RSIEXSN7ZIc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q59FP4 intact:EBI-9356629 intact:EBI-9374370 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q59fp4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374413|imex:IM-22301-834 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 intact-crc:31AF3D69549D80EB|rigid:gRgfj/3kt2OtdieWt/u99YK7jIo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FP4 uniprotkb:Q53FC7 intact:EBI-9374370 intact:EBI-9356749 psi-mi:q59fp4_human(display_long) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374435|imex:IM-22301-835 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:E4E9E5A656C62AFD|rigid:uvW4GDOTnCwKkLAvnpvGBV1l9bU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FP4 uniprotkb:Q8IVD9 intact:EBI-9374370 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q59fp4_human(display_long) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374457|imex:IM-22301-836 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:CDCC9948D01F5D4A|rigid:TwaGuOeJOZqH5GuMkN+wftKuzMo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q59FP4 intact:EBI-9357028 intact:EBI-9374370 psi-mi:b4dyc6_human(display_long) psi-mi:q59fp4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374476|imex:IM-22301-837 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 intact-crc:7FC734EB8F6DB06C|rigid:LKi7HDpcEilpV36MngOAsy93TmI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FP4 uniprotkb:Q13200 intact:EBI-9374370 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q59fp4_human(display_long) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374496|imex:IM-22301-838 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:C7B7196CB20336AF|rigid:ZiJvJzJEioFXLphLiuXTDFPusvM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q59FP4 intact:EBI-9356686 intact:EBI-9374370 psi-mi:q96be0_human(display_long) psi-mi:q59fp4_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374518|imex:IM-22301-839 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 intact-crc:F9A3ACA435E2E8CD|rigid:51PpqaZ2Wf//icHYvDt2p6OwS9s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59G26 uniprotkb:P58340 intact:EBI-9374562 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q59g26_human(display_long) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374565|imex:IM-22301-841 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:6580937834A752AC|rigid:JQLNrg8LY+xhCTe+TNKC/2iWQdY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59FP4 uniprotkb:Q9BTE6-2 intact:EBI-9374370 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q59fp4_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374540|imex:IM-22301-840 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0016301"(kinase activity)|uniprotkb:Q59FP4(identity)|human orfeome collection:2430(identity)|ddbj/embl/genbank:BC001554(identity)|entrezgene/locuslink:3611(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:soHGMjNVvey2FcqKXghm52xgpDw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:79D90D5A1F3AC829|rigid:Hfa19dTjdNfPRpmeswWHZ1AfwUQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q59G26 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9374562 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q59g26_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374587|imex:IM-22301-842 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 intact-crc:6F8F9CFC56CBF1A1|rigid:YiDunu/FKc9m14MrotitnJqe4PQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59G26 uniprotkb:Q9UHV9 intact:EBI-9374562 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:q59g26_human(display_long) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374609|imex:IM-22301-843 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:AD52A2CA31A45E79|rigid:nhISDwoFSyguiLyZdhk2HcaC8CA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q59G26 intact:EBI-9357028 intact:EBI-9374562 psi-mi:b4dyc6_human(display_long) psi-mi:q59g26_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374629|imex:IM-22301-844 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 intact-crc:91F5A862385842DB|rigid:HbaxxLOY+LrJEPzShWq72xOF0w4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59G26 uniprotkb:Q96BE0 intact:EBI-9374562 intact:EBI-9356686 psi-mi:q59g26_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374649|imex:IM-22301-845 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:A997F2797B61C318|rigid:LB06VcoiePFem4aKm9sJBbLImKw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q59G26 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9374562 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q59g26_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374671|imex:IM-22301-846 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 intact-crc:B55100C886154136|rigid:gLxvpM7ycThkHrNHHAHdS4yomrs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q59G26 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-9374562 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:q59g26_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374690|imex:IM-22301-847 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|entrezgene/locuslink:2784(identity)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 intact-crc:D5339110AA5AD5FB|rigid:4QlsljmEWq0qx3CzNEKspIpEf1Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q59GD3 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9374734 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q59gd3_human(display_long)|uniprotkb:Voltage-dependent L-type calcium channel subunit beta-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374731|imex:IM-22301-849 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042383"(sarcolemma)|uniprotkb:Q59GD3(identity)|human orfeome collection:2367(identity)|entrezgene/locuslink:782(identity)|ddbj/embl/genbank:BC037311(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:2u0sM967cDRI0w0dOYr/ufZR34w9606 intact-crc:6F08DE7718ED1095|rigid:zabdBiT+OifOI3GaHRwfZlzCI5U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59G26 uniprotkb:Q9BTE6-2 intact:EBI-9374562 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q59g26_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374709|imex:IM-22301-848 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0007165"(signal transduction)|uniprotkb:Q59G26(identity)|ddbj/embl/genbank:BC015920(identity)|human orfeome collection:7259(identity)|entrezgene/locuslink:2784(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vr6hkWw2IYVgoEMT9rVWnwpw1L49606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:6AB5005107D92D57|rigid:JZDrtLrT98j0qT4AmqN0E1UgNcM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q59GL9 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9374756 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q59gl9_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374753|imex:IM-22301-850 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 intact-crc:A1DC796DC4B28250|rigid:1uWtYd4HHC3vABtiNxfUhZprGc4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q59GL9 intact:EBI-9356629 intact:EBI-9374756 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q59gl9_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374777|imex:IM-22301-851 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 intact-crc:68D676FCC4833101|rigid:lb1aV3RB15nlFMR0jXf9aLCPRis false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GL9 uniprotkb:Q96BE0 intact:EBI-9374756 intact:EBI-9356686 psi-mi:q59gl9_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374818|imex:IM-22301-853 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:F8A3AF321D107198|rigid:KcvteZqhApekrCt7QsEw+a3aROw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q59GL9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9374756 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q59gl9_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374799|imex:IM-22301-852 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 intact-crc:5D9C80DF4AA6D912|rigid:kOYhwFSeryUgBcl+FcDT7Ana8po false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GL9 uniprotkb:P31948 intact:EBI-9374756 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q59gl9_human(display_long) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374840|imex:IM-22301-854 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:E19B08C8BA770A92|rigid:wGgNCUQfZKWbt6yg/e8cxrrOA8A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GL9 uniprotkb:Q16543 intact:EBI-9374756 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q59gl9_human(display_long) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374859|imex:IM-22301-855 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:1B080A9AC7013315|rigid:8nFONG99ck+v9FLpA3wbQxvml+w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GL9 uniprotkb:Q9BTE6-2 intact:EBI-9374756 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q59gl9_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374879|imex:IM-22301-856 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:4FD39449DB456D81|rigid:faDJ9SHh9lkrPRU15KtAtQmLq00 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GL9 uniprotkb:Q9BPW0 intact:EBI-9374756 intact:EBI-9356778 psi-mi:q59gl9_human(display_long) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374901|imex:IM-22301-857 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR029071|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GL9(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity)|human orfeome collection:71517(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:C103iqbhSkB+hT3n+00aKxw0u8s9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:EA189C6870F241BA|rigid:RIlcV4ElcTeQi1GiIY4QsCJGvBc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GT1 uniprotkb:Q6PK50 intact:EBI-9374923 intact:EBI-9356629 psi-mi:q59gt1_human(display_long) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374926|imex:IM-22301-858 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GT1(identity)|entrezgene/locuslink:1147(identity)|human orfeome collection:70452(identity)|ddbj/embl/genbank:BC092514(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ll1K7xT0/ydZh9s8Isfb1qjZxb09606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:84844431A97E84F6|rigid:JSdVzY3AxyxSQRnr9qEAOLoOKlQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GT1 uniprotkb:P07900 intact:EBI-9374923 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q59gt1_human(display_long) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374948|imex:IM-22301-859 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GT1(identity)|entrezgene/locuslink:1147(identity)|human orfeome collection:70452(identity)|ddbj/embl/genbank:BC092514(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ll1K7xT0/ydZh9s8Isfb1qjZxb09606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:5B478F21E0C295F5|rigid:PeQzlzGkEHjmKiC8aucyhixhuQc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q59GT1 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9374923 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q59gt1_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374969|imex:IM-22301-860 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GT1(identity)|entrezgene/locuslink:1147(identity)|human orfeome collection:70452(identity)|ddbj/embl/genbank:BC092514(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:ll1K7xT0/ydZh9s8Isfb1qjZxb09606 intact-crc:53002639D29D5A31|rigid:soajaK8vcPIzZ/KMNkAil+hd7xU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GT1 uniprotkb:Q16543 intact:EBI-9374923 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q59gt1_human(display_long) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9374988|imex:IM-22301-861 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GT1(identity)|entrezgene/locuslink:1147(identity)|human orfeome collection:70452(identity)|ddbj/embl/genbank:BC092514(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ll1K7xT0/ydZh9s8Isfb1qjZxb09606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:BA434C9FAD36EE36|rigid:z56wTBfg63Wr/NxTdJDpgqOo0W8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59GT1 uniprotkb:Q9BPW0 intact:EBI-9374923 intact:EBI-9356778 psi-mi:q59gt1_human(display_long) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375008|imex:IM-22301-862 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041185|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008384"(IkappaB kinase activity)|uniprotkb:Q59GT1(identity)|entrezgene/locuslink:1147(identity)|human orfeome collection:70452(identity)|ddbj/embl/genbank:BC092514(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ll1K7xT0/ydZh9s8Isfb1qjZxb09606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:EF694FB622701B24|rigid:6pOpiPjxfBOLw+x6w7fcUXMUH/8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59H13 uniprotkb:P58340 intact:EBI-9375030 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q59h13_human(display_long) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375033|imex:IM-22301-863 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|go:"GO:0003824"(catalytic activity)|uniprotkb:Q59H13(identity)|human orfeome collection:54728(identity)|entrezgene/locuslink:240(identity)|ddbj/embl/genbank:BC130332(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTGDBYWrTTim2Z1UEraTbAgZjtY9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:20105EDF755F70F7|rigid:wSR3X6oLNTl1eC3WtKj6qoxLZVk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q59H13 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9375030 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q59h13_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375055|imex:IM-22301-864 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|go:"GO:0003824"(catalytic activity)|uniprotkb:Q59H13(identity)|human orfeome collection:54728(identity)|entrezgene/locuslink:240(identity)|ddbj/embl/genbank:BC130332(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:lTGDBYWrTTim2Z1UEraTbAgZjtY9606 intact-crc:8A4371168EC0021A|rigid:QD2tC0MaiAKG5I1WPw6rsMH1KJI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q59H13 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9375030 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q59h13_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375076|imex:IM-22301-865 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|go:"GO:0003824"(catalytic activity)|uniprotkb:Q59H13(identity)|human orfeome collection:54728(identity)|entrezgene/locuslink:240(identity)|ddbj/embl/genbank:BC130332(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:lTGDBYWrTTim2Z1UEraTbAgZjtY9606 intact-crc:1C7833D2BD826E76|rigid:+Y5opEnz5024q82dORkwr3PWkVw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q59H13 uniprotkb:Q9UIM3 intact:EBI-9375030 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:q59h13_human(display_long) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375098|imex:IM-22301-866 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|go:"GO:0003824"(catalytic activity)|uniprotkb:Q59H13(identity)|human orfeome collection:54728(identity)|entrezgene/locuslink:240(identity)|ddbj/embl/genbank:BC130332(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTGDBYWrTTim2Z1UEraTbAgZjtY9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:0EEC19E5FCA829C6|rigid:K1Xyjd4xf07j9fpV2IWe7y50UQQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q5C8S5 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9375120 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q5c8s5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375117|imex:IM-22301-867 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|go:"GO:0003677"(DNA binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030284"(estrogen receptor activity)|uniprotkb:Q5C8S5(identity)|human orfeome collection:56919(identity)|ddbj/embl/genbank:BC128573(identity)|entrezgene/locuslink:2099(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:fEzEMZwl50lsO1KiUi+Sc7Lwjhg9606 intact-crc:1FB82A9ECC661116|rigid:ca5H9rERZovqOEvDKBY16GMNtqg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5C8S5 uniprotkb:Q53FC7 intact:EBI-9375120 intact:EBI-9356749 psi-mi:q5c8s5_human(display_long) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375141|imex:IM-22301-868 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|go:"GO:0003677"(DNA binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030284"(estrogen receptor activity)|uniprotkb:Q5C8S5(identity)|human orfeome collection:56919(identity)|ddbj/embl/genbank:BC128573(identity)|entrezgene/locuslink:2099(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fEzEMZwl50lsO1KiUi+Sc7Lwjhg9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:9F6673625B24A42F|rigid:uiMrskI+6nceQxNffPmHwGWwoco false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5C8S5 uniprotkb:O95429 intact:EBI-9375120 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:q5c8s5_human(display_long) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375163|imex:IM-22301-869 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|go:"GO:0003677"(DNA binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030284"(estrogen receptor activity)|uniprotkb:Q5C8S5(identity)|human orfeome collection:56919(identity)|ddbj/embl/genbank:BC128573(identity)|entrezgene/locuslink:2099(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fEzEMZwl50lsO1KiUi+Sc7Lwjhg9606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:1188E49C7E455709|rigid:Ck8Xa0+YpgZMEMgd9ZOyscb2xV8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5C8S5 uniprotkb:Q96BE0 intact:EBI-9375120 intact:EBI-9356686 psi-mi:q5c8s5_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375185|imex:IM-22301-870 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|go:"GO:0003677"(DNA binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030284"(estrogen receptor activity)|uniprotkb:Q5C8S5(identity)|human orfeome collection:56919(identity)|ddbj/embl/genbank:BC128573(identity)|entrezgene/locuslink:2099(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fEzEMZwl50lsO1KiUi+Sc7Lwjhg9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:36CF9CE54695FA69|rigid:hoZ6OuHpY3lEePFX1KMN2XfW2To false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:P58340 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375207|imex:IM-22301-871 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:5A555F767CDF5415|rigid:hOZSlY5jWB13gMTrFCcSQvm+jbg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q6PK50 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-9356629 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375229|imex:IM-22301-872 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:CCDAB93DBE70ABBB|rigid:/lYOfiho2v3Z6/gdWaFVjzhd8tA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q03933 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375251|imex:IM-22301-873 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:B89897CF200F384E|rigid:rrtppIBHgpucd34XkE6w3mvRkws false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q9Y266 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375270|imex:IM-22301-874 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:52DB9CB8407F83E8|rigid:4KLk0E4lWiNIavl5SOfv2DfLW9k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q8IVD9 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375289|imex:IM-22301-875 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:C1E1FB50AAF500DB|rigid:Q1zwbwWx8cURJPWQ0iJdAntq414 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:O43765 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375308|imex:IM-22301-876 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:18ECB2F003262611|rigid:KrB8i7yG2zU7OsiAMO+5kIsts5k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q96BE0 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-9356686 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375330|imex:IM-22301-877 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:22C067412A5B711E|rigid:ANXfd911hNpjLD8R49l2uyv99GM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q9UNE7 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375352|imex:IM-22301-878 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:5F8A7604DE103126|rigid:eAeP3LRnv3W9r6JzkTLT+se6Xn0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q9HB71 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375374|imex:IM-22301-879 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:0BCF8D9A9CA5CFD8|rigid:h8anFT+rzbJLb4Gt+aFfLpcdcb8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5H9I0 uniprotkb:Q9BTE6-2 intact:EBI-6427267|ensembl:ENSP00000385461|uniprotkb:Q9NZ54|uniprotkb:Q6DK49 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:tfdp3_human(display_long)|uniprotkb:TFDP3(gene name)|psi-mi:TFDP3(display_short)|uniprotkb:Cancer/testis antigen 30(gene name synonym)|uniprotkb:DP4(gene name synonym)|uniprotkb:HCA661(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 661(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375393|imex:IM-22301-880 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183434(gene)|ensembl:ENST00000310125(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR014889(Transcription factor DP, C-terminal)|interpro:IPR015648(Transcription factor DP)|interpro:IPR028315|interpro:IPR036388|interpro:IPR036390|interpro:IPR038168|interpro:IPR037241|refseq:NP_057605.3|uniprotkb:Q5H9I0(identity)|entrezgene/locuslink:51270(identity)|human orfeome collection:54134(identity)|ddbj/embl/genbank:BC117336(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9XVDy+28f0NeDvdXBrPPUAoLxcU9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:689A0071E9FDF1EC|rigid:TQVeqrLh7+dBfCSbk8eIUJ8nMwA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P22681 uniprotkb:Q5JPT3 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-9375415|ensembl:ENSP00000409292 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:q5jpt3_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375419|imex:IM-22301-881 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) ensembl:ENSG00000147010(gene)|ensembl:ENST00000431164(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035771|interpro:IPR036028|uniprotkb:Q5JPT3(identity)|ddbj/embl/genbank:BC015806(identity)|entrezgene/locuslink:30011(identity)|human orfeome collection:164(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:EQK7eXrstdobOmomwYYqsrh4/FM9606 intact-crc:8C76BC829E64F64A|rigid:Z5HHmIX+hS0EV27+vpy81zwYqhA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5QNY5 uniprotkb:P31948 intact:EBI-9375442|ensembl:ENSP00000376054 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q5qny5_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:Peroxisomal biogenesis factor 19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375439|imex:IM-22301-882 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162735(gene)|ensembl:ENST00000392220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0007031"(peroxisome organization)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|uniprotkb:Q5QNY5(identity)|human orfeome collection:3171(identity)|entrezgene/locuslink:5824(identity)|ddbj/embl/genbank:BC000496(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CU6np4SokeFfofQ/NTbsCfqtETI9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:A8F96F4D7FDB57F7|rigid:5uV3et29rd9O1gw5cyfLHou61YU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q5T6U8 intact:EBI-9356749 intact:EBI-9375486 psi-mi:q53fc7_human(display_long) psi-mi:q5t6u8_human(display_long)|uniprotkb:HMGA1(gene name)|psi-mi:HMGA1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375483|imex:IM-22301-884 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001306006.1|interpro:IPR000116(High mobility group, HMG-I and HMG-Y)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR017956|refseq:NP_002122.1|refseq:NP_665909.1|refseq:NP_665910.1|refseq:NP_665912.1|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|uniprotkb:Q5T6U8(identity)|entrezgene/locuslink:3159(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:QL8/APvYERa2EQdmzd5srAdhpkk9606 intact-crc:A69E4B6F510565C9|rigid:AvKWaaY5I5+nkIjj7XhWKRQs4bM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q5SSJ5 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-2880687|ensembl:ENSP00000312625|ensembl:ENSP00000403039|uniprotkb:Q5SWC6|uniprotkb:Q6PIM9|uniprotkb:B3KMZ8|uniprotkb:A8K5D7|uniprotkb:Q8NDF0|uniprotkb:Q05BI0|uniprotkb:B4E210|uniprotkb:A6NI71|uniprotkb:Q9UHY0|uniprotkb:Q5SSJ6 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:hp1b3_human(display_long)|uniprotkb:HP1BP3(gene name)|psi-mi:HP1BP3(display_short)|uniprotkb:Protein HP1-BP74(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375462|imex:IM-22301-883 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) ensembl:ENSG00000127483(gene)|ensembl:ENST00000312239(transcript)|ensembl:ENST00000438032(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097298"(regulation of nucleus size)|interpro:IPR005818(Histone H1/H5)|interpro:IPR033061|interpro:IPR036388|interpro:IPR036390|mint:Q5SSJ5|rcsb pdb:2RQP|go:"GO:0005694"(chromosome)|refseq:XP_016856882.1|refseq:XP_016856883.1|refseq:XP_011539834.1|refseq:XP_011539835.1|refseq:XP_011539836.1|refseq:NP_057371.2|refseq:XP_005245932.1|refseq:XP_005245933.1|refseq:XP_005245934.1|refseq:XP_005245935.1|refseq:XP_005245936.1|uniprotkb:Q5SSJ5(identity)|ddbj/embl/genbank:BC046170(identity)|human orfeome collection:55608(identity)|entrezgene/locuslink:50809(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:kLFithZZv+Qn9YLElEnX81awKDw9606 intact-crc:54CA8CF18BF4264A|rigid:Q9Bjz2m7aaMRpA7H/MVKPo8Ro38 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q13451 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375507|imex:IM-22301-885 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:E08D08AC9FFE4F84|rigid:KidQYd8zIoMcFl5zFlVA1Ghmjlg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q5T7U4 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9375510|ensembl:ENSP00000389498 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375530|imex:IM-22301-886 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 intact-crc:74BCC2858DF43E1B|rigid:kUuOh1/8V6ScJ1fzkAaoQ/W8peQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q15773 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375552|imex:IM-22301-887 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:0168DA27856114D6|rigid:EwqI1A/vC+vsn3KYNwpBkTfeOvs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q53FC7 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-9356749 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375574|imex:IM-22301-888 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:7B609D2A13B23932|rigid:XCSrkRYYHEkjgNV0xUpu7KuXYN4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q9Y266 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375615|imex:IM-22301-890 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:1ACDAFB9C3479F56|rigid:3XSNsUsnmowugMBDpfN7I17YLfo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q03933 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375596|imex:IM-22301-889 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:332A3124DA75B576|rigid:I03h9lekx21wkXysr/DF58XB6fc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q8IVD9 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375634|imex:IM-22301-891 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:A726AA9D6ABCF1A9|rigid:t9yfKoMOvt/LR1IBn25TRjJ1acc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q13200 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375653|imex:IM-22301-892 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:571FCAF6133980DB|rigid:BIffpyN3eH50OcesjvugMjWwNOk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:Q5T7U4 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-9375510|ensembl:ENSP00000389498 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375675|imex:IM-22301-893 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 intact-crc:C302A06AE25259A5|rigid:v9IsSHzZpi6op03/DWhEhOls2Eg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q5T7U4 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-9375510|ensembl:ENSP00000389498 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375697|imex:IM-22301-894 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 intact-crc:A61B5E17F7716593|rigid:43EKyf5+e1N81aSz1QLHuzPj1n4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q96BE0 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-9356686 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375718|imex:IM-22301-895 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1ADEACA534E07C36|rigid:+npWatWmdW4p60W8uEDcCp4GL5A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q5T7U4 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9375510|ensembl:ENSP00000389498 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375740|imex:IM-22301-896 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 intact-crc:C1A7F3A457752497|rigid:cBENIE8YB8vBQIcDlnbC/p9FFJA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q5T7U4 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9375510|ensembl:ENSP00000389498 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375759|imex:IM-22301-897 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 intact-crc:ECF40BA5B4EEBAA9|rigid:dgSfi4fyz3M0Pp0VdtAfhG9uboY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T7U4 uniprotkb:Q9BTE6-2 intact:EBI-9375510|ensembl:ENSP00000389498 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q5t7u4_human(display_long)|uniprotkb:GTF3C5(gene name)|psi-mi:GTF3C5(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375781|imex:IM-22301-898 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000148308(gene)|ensembl:ENST00000440319(transcript)|go:"GO:0000127"(transcription factor TFIIIC complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|interpro:IPR019136|interpro:IPR040454|interpro:IPR041499|interpro:IPR042536|uniprotkb:Q5T7U4(identity)|ddbj/embl/genbank:BC011355(identity)|human orfeome collection:2878(identity)|entrezgene/locuslink:9328(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JJMQjjRMfAMrkFG+nPajQWMhjvY9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:F5079179A3847EF1|rigid:aCxXdfgkPbgLviH7Y8OyuFyx/tw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q5T853 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9375803|ensembl:ENSP00000391275 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375807|imex:IM-22301-899 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 intact-crc:0DAAB6E8A79D8DE4|rigid:dIMf8qWhi+F/54p02KDyQM6A16A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q5T853 intact:EBI-9356629 intact:EBI-9375803|ensembl:ENSP00000391275 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375826|imex:IM-22301-900 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 intact-crc:544F9FE872D15BD0|rigid:7tOYM6VwN9LbdgGZ8GSo7FM47js false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T853 uniprotkb:Q53FC7 intact:EBI-9375803|ensembl:ENSP00000391275 intact:EBI-9356749 psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375848|imex:IM-22301-901 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:09FCD3A093F72867|rigid:3tbBmEo+VIdYlyLOUZ8KOoNVh1A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q5T853 intact:EBI-9357028 intact:EBI-9375803|ensembl:ENSP00000391275 psi-mi:b4dyc6_human(display_long) psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375870|imex:IM-22301-902 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 intact-crc:63FB582AF7D8B858|rigid:FSuAeZGm+I80eAamo4moH3lk7Jk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T853 uniprotkb:Q96BE0 intact:EBI-9375803|ensembl:ENSP00000391275 intact:EBI-9356686 psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375890|imex:IM-22301-903 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:6868766CEF4D3522|rigid:ecz/tXnNQPexEfnpgRs53x4stDU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T853 uniprotkb:P07900 intact:EBI-9375803|ensembl:ENSP00000391275 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375912|imex:IM-22301-904 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:BCEFCD117C30BFF1|rigid:dT0+GGkU2e8DD8v/ZZ/3Z5sAzsI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q5T853 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9375803|ensembl:ENSP00000391275 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375933|imex:IM-22301-905 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 intact-crc:804C99A9A697356D|rigid:zk4ozCIzf1YuTB6HlDmsLqnlea8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T853 uniprotkb:Q9BPW0 intact:EBI-9375803|ensembl:ENSP00000391275 intact:EBI-9356778 psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375972|imex:IM-22301-907 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:E53603C533CF94D2|rigid:RBcXRwb7BLY+7FwmMfKnQ6nqy0s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5T853 uniprotkb:Q16543 intact:EBI-9375803|ensembl:ENSP00000391275 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q5t853_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375952|imex:IM-22301-906 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107968(gene)|ensembl:ENST00000413724(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|uniprotkb:Q5T853(identity)|ddbj/embl/genbank:BC113566(identity)|entrezgene/locuslink:1326(identity)|human orfeome collection:53709(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tIiQY2dya+pxY2new/F5fB3xXpI9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:6CD62BCD7BB69D28|rigid:STmTq3SgEW8LwPWVg2FZIPCs2y0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TA56 uniprotkb:Q6PK50 intact:EBI-9375997|ensembl:ENSP00000317425|ensembl:ENSP00000380928 intact:EBI-9356629 psi-mi:q5ta56_human(display_long)|uniprotkb:AGO3(gene name)|psi-mi:AGO3(display_short)|uniprotkb:EIF2C3(gene name synonym)|uniprotkb:hCG_1640521(orf name) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9375994|imex:IM-22301-908 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126070(gene)|ensembl:ENST00000324350(transcript)|ensembl:ENST00000397828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032474|interpro:IPR036085|go:"GO:0003743"(translation initiation factor activity)|uniprotkb:Q5TA56(identity)|human orfeome collection:11034(identity)|entrezgene/locuslink:192669(identity)|ddbj/embl/genbank:BC066888(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kw7z6KKymX4mrCiV1Z4tEp5JvHI9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:156B07FB8000C6CD|rigid:2eS4XEK+mQgO2v4ryJ/mvI6CLsQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TA56 uniprotkb:P07900 intact:EBI-9375997|ensembl:ENSP00000317425|ensembl:ENSP00000380928 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q5ta56_human(display_long)|uniprotkb:AGO3(gene name)|psi-mi:AGO3(display_short)|uniprotkb:EIF2C3(gene name synonym)|uniprotkb:hCG_1640521(orf name) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376020|imex:IM-22301-909 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126070(gene)|ensembl:ENST00000324350(transcript)|ensembl:ENST00000397828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032474|interpro:IPR036085|go:"GO:0003743"(translation initiation factor activity)|uniprotkb:Q5TA56(identity)|human orfeome collection:11034(identity)|entrezgene/locuslink:192669(identity)|ddbj/embl/genbank:BC066888(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kw7z6KKymX4mrCiV1Z4tEp5JvHI9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:68EEBF42CB1D8063|rigid:7DCxCaBa2Ag2pRN948Bs8eFHIjo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TA56 uniprotkb:Q15185 intact:EBI-9375997|ensembl:ENSP00000317425|ensembl:ENSP00000380928 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:q5ta56_human(display_long)|uniprotkb:AGO3(gene name)|psi-mi:AGO3(display_short)|uniprotkb:EIF2C3(gene name synonym)|uniprotkb:hCG_1640521(orf name) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376041|imex:IM-22301-910 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126070(gene)|ensembl:ENST00000324350(transcript)|ensembl:ENST00000397828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032474|interpro:IPR036085|go:"GO:0003743"(translation initiation factor activity)|uniprotkb:Q5TA56(identity)|human orfeome collection:11034(identity)|entrezgene/locuslink:192669(identity)|ddbj/embl/genbank:BC066888(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kw7z6KKymX4mrCiV1Z4tEp5JvHI9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:EEB7C1D62F1BE76C|rigid:qCOTusFzx+1aJBmyMoen1j1OUOk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TA56 uniprotkb:Q9BPW0 intact:EBI-9375997|ensembl:ENSP00000317425|ensembl:ENSP00000380928 intact:EBI-9356778 psi-mi:q5ta56_human(display_long)|uniprotkb:AGO3(gene name)|psi-mi:AGO3(display_short)|uniprotkb:EIF2C3(gene name synonym)|uniprotkb:hCG_1640521(orf name) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376061|imex:IM-22301-911 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126070(gene)|ensembl:ENST00000324350(transcript)|ensembl:ENST00000397828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032474|interpro:IPR036085|go:"GO:0003743"(translation initiation factor activity)|uniprotkb:Q5TA56(identity)|human orfeome collection:11034(identity)|entrezgene/locuslink:192669(identity)|ddbj/embl/genbank:BC066888(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kw7z6KKymX4mrCiV1Z4tEp5JvHI9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:D6BD511047473C9A|rigid:Yhj0Nwt+tcEKqx5R7rSiYZN5X9U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q5TZT0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9376083 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q5tzt0_human(display_long)|uniprotkb:TREX1(gene name)|psi-mi:TREX1(display_short)|uniprotkb:hCG_1997849(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376087|imex:IM-22301-912 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|refseq:NP_009179.2|interpro:IPR036397|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q5TZT0(identity)|ddbj/embl/genbank:BC023630(identity)|human orfeome collection:12535(identity)|entrezgene/locuslink:11277(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:TyTxonayOZBoHQMGAscHPe5GafM9606 intact-crc:F016164403F972AF|rigid:Y1NkdK/GfseufA5XNaS4EtEpzDs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TZT0 uniprotkb:Q6PK50 intact:EBI-9376083 intact:EBI-9356629 psi-mi:q5tzt0_human(display_long)|uniprotkb:TREX1(gene name)|psi-mi:TREX1(display_short)|uniprotkb:hCG_1997849(orf name) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376108|imex:IM-22301-913 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|refseq:NP_009179.2|interpro:IPR036397|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q5TZT0(identity)|ddbj/embl/genbank:BC023630(identity)|human orfeome collection:12535(identity)|entrezgene/locuslink:11277(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:TyTxonayOZBoHQMGAscHPe5GafM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:3BF94461BAF9F8C6|rigid:ISdBqqsATDRiUt8U0H9kpDurpN0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5TZT0 uniprotkb:B4DYC6 intact:EBI-9376083 intact:EBI-9357028 psi-mi:q5tzt0_human(display_long)|uniprotkb:TREX1(gene name)|psi-mi:TREX1(display_short)|uniprotkb:hCG_1997849(orf name) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376130|imex:IM-22301-914 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|refseq:NP_009179.2|interpro:IPR036397|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q5TZT0(identity)|ddbj/embl/genbank:BC023630(identity)|human orfeome collection:12535(identity)|entrezgene/locuslink:11277(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:TyTxonayOZBoHQMGAscHPe5GafM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:CA59C2A8377CFBEF|rigid:ms8nALIpsDw0Tpy7Ck5VrzyDPzU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q5ULA9 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9376150 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376154|imex:IM-22301-915 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:A17EE09BFAEF4970|rigid:2vpMmr4RLD0Mz30RBWIIT+fnrXY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5ULA9 uniprotkb:Q15773 intact:EBI-9376150 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376176|imex:IM-22301-916 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:C2733F75FD33AA6D|rigid:tnaA+sPvmgMv2TsHgTCGw++KSUg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q5ULA9 intact:EBI-9356629 intact:EBI-9376150 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376198|imex:IM-22301-917 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:0C855406B538AF78|rigid:m0naEOnzFn8XVSVhv3gywCgD/r4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5ULA9 uniprotkb:O95816 intact:EBI-9376150 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376220|imex:IM-22301-918 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:404455E7E71FD1BF|rigid:0qNkrVSIA/wjE4mG+6Pqwv4OGVY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q5ULA9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9376150 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376242|imex:IM-22301-919 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:449611E882CCFD90|rigid:aHECh4jzWoVTDq52GZsTkJWJSyY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q5ULA9 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9376150 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376261|imex:IM-22301-920 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:14FF9C1EC34B2F81|rigid:VS2bF44J4d5aPc2x1jP1F/VIBOg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q5ULA9 intact:EBI-9356686 intact:EBI-9376150 psi-mi:q96be0_human(display_long) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376283|imex:IM-22301-921 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:0E7E1F9129687477|rigid:0JJjrerItOebL4ghs+4qw6/NANY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q5ULA9 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9376150 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376305|imex:IM-22301-922 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:FE565FBE18256E78|rigid:0/xxtRb8TkQCEf6lHUFVf7K7vCI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5ULA9 uniprotkb:Q9UNE7 intact:EBI-9376150 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376324|imex:IM-22301-923 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:5411ACB6D2333873|rigid:OWru78/hdi26mOQHfroQAA8al8Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q5ULA9 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9376150 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q5ula9_human(display_long)|uniprotkb:MAOA(gene name)|psi-mi:MAOA(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376346|imex:IM-22301-924 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) uniprotkb:Q5ULA9(identity)|human orfeome collection:4497(identity)|ddbj/embl/genbank:BC008064(identity)|entrezgene/locuslink:4128(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:XmprWgZkAGdxSlNlthVIqpiH/GQ9606 intact-crc:7C156EE504D711E0|rigid:LJmoTsAkuBkTGEBSBmY/PSrlkQ8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q5VVK9 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9376371|ensembl:ENSP00000359158 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q5vvk9_human(display_long)|uniprotkb:TRMT13(gene name)|psi-mi:TRMT13(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376368|imex:IM-22301-925 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000122435(gene)|ensembl:ENST00000370139(transcript)|go:"GO:0046872"(metal ion binding)|go:"GO:0106050"(tRNA 2'-O-methyltransferase activity)|interpro:IPR022776|interpro:IPR039044|uniprotkb:Q5VVK9(identity)|ddbj/embl/genbank:BC075811(identity)|human orfeome collection:71269(identity)|entrezgene/locuslink:54482(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:jPM9OyoW4TQhU9cWmrw14Y53DXE9606 intact-crc:C1C1BE74B4828748|rigid:I4dbqAPJR/hwGpXxEaKQNI1Vui0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q5W0B1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2562035|uniprotkb:Q9H8M0|uniprotkb:B2RN99|uniprotkb:Q9H0T2|uniprotkb:Q8TBY2|ensembl:ENSP00000282003 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:obi1_human(display_long)|uniprotkb:OBI1(gene name)|psi-mi:OBI1(display_short)|uniprotkb:C13orf7(gene name synonym)|uniprotkb:RING finger protein 219(gene name synonym)|uniprotkb:RNF219(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376393|imex:IM-22301-926 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_078822.3|ensembl:ENSG00000152193(gene)|ensembl:ENST00000282003(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR035691|interpro:IPR039209|mint:Q5W0B1|uniprotkb:Q5W0B1(identity)|human orfeome collection:1639(identity)|ddbj/embl/genbank:BC028586(identity)|entrezgene/locuslink:79596(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:MCzyMLZ+OMynQerFlsiwIHPRc0M9606 intact-crc:A364A02B57905BD7|rigid:HcSiyhelbQm21bjJy36lNldN8f4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6AI12 uniprotkb:Q96BE0 intact:EBI-2838246|uniprotkb:Q96E32|ensembl:ENSP00000285243 intact:EBI-9356686 psi-mi:anr40_human(display_long)|uniprotkb:ANKRD40(gene name)|psi-mi:ANKRD40(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376412|imex:IM-22301-927 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_443087.1|ensembl:ENSG00000154945(gene)|ensembl:ENST00000285243(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR036770|interpro:IPR039195|mint:Q6AI12|uniprotkb:Q6AI12(identity)|entrezgene/locuslink:91369(identity)|human orfeome collection:6574(identity)|ddbj/embl/genbank:BC012978(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:N90IlLrtlIyntctaIJLemc16yqI9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1AE9E53DA8877443|rigid:bTp6QKqmYnTEUqkgIN1tIPnxNV0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FH24 uniprotkb:Q9UHV9 intact:EBI-9376437 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:q6fh24_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:hCG_17616(orf name) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376434|imex:IM-22301-928 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR009053(Prefoldin)|refseq:NP_001290474.1|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR016655(Prefoldin, subunit 3)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|uniprotkb:Q6FH24(identity)|human orfeome collection:11664(identity)|ddbj/embl/genbank:BC046094(identity)|entrezgene/locuslink:7411(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:zh1rio8FdptSgp6keJt5gXSWtRY9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:8C18655BF3737EA2|rigid:y5l5/tJBVGX5VgaIQqVfGCsMirc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q6FH24 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-9376437 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:q6fh24_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:hCG_17616(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376458|imex:IM-22301-929 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) interpro:IPR009053(Prefoldin)|refseq:NP_001290474.1|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR016655(Prefoldin, subunit 3)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|uniprotkb:Q6FH24(identity)|human orfeome collection:11664(identity)|ddbj/embl/genbank:BC046094(identity)|entrezgene/locuslink:7411(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:zh1rio8FdptSgp6keJt5gXSWtRY9606 intact-crc:F043C53C20BC10C4|rigid:kQ21zZ2Sfhkhk5ahEHR64G7c1/w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHF7 uniprotkb:P58340 intact:EBI-9376480 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376477|imex:IM-22301-930 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:A38BA71060924B7C|rigid:186VGS35kKut5IcFK1vMdtezi/0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q6FHF7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9376480 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376503|imex:IM-22301-931 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:7ADC279CDFA21B3E|rigid:p1ahQtJjk3F2E6xWn2OUwApfSSo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHF7 uniprotkb:Q15773 intact:EBI-9376480 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376524|imex:IM-22301-932 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:055AEFFEEB3B1F43|rigid:YjzN4DrT1xhpCdr34ZCndTvOyuY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHF7 uniprotkb:Q9HAV2 intact:EBI-9376480 intact:EBI-9357141 psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376546|imex:IM-22301-933 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:B29FC0D26E81BBA9|rigid:9W4wF4oLxPpuGEzIeKCW0VZndIU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q6FHF7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9376480 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376568|imex:IM-22301-934 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:E22373042F0A3C5C|rigid:qX3TxyWzCBR9K3FeZ7TCGUCko74 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHF7 uniprotkb:B4DYC6 intact:EBI-9376480 intact:EBI-9357028 psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376587|imex:IM-22301-935 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:7378320E4F057B03|rigid:RP4ufInanxQ/NA5Dh1+xVrrWuxc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q6FHF7 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9376480 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376629|imex:IM-22301-937 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:D1DBC6D1F2AA9005|rigid:TI8sQOqcT4IKGFb3kpO4/ihIf+c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q6FHF7 intact:EBI-9356686 intact:EBI-9376480 psi-mi:q96be0_human(display_long) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376607|imex:IM-22301-936 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:6EBEE43D5E668438|rigid:gTqEjIfQSgxi9SnPk1KrBx8SdLs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHF7 uniprotkb:Q9UIM3 intact:EBI-9376480 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376648|imex:IM-22301-938 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:6E850A7E5EF3F3C8|rigid:CpYT6hW1Pb0vRyS4zmq3YXO1oao false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q6FHF7 intact:EBI-9356778 intact:EBI-9376480 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376667|imex:IM-22301-939 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093(identity)|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:F83D73618392810D|rigid:rYXSMJ9YJu6zos4Fh3kVrfRw/6Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q6FHM2 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-1640450 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376689|imex:IM-22301-940 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:442CF143649F45B4|rigid:Fe6+DhOAJ+fs2wtxM0t7M4CuDN0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q6FHM2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1640450 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376711|imex:IM-22301-941 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:F1A833D736964C2C|rigid:GqZdTbMDDyOOzktwUvTyQ3szuDc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q15773 intact:EBI-1640450 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376732|imex:IM-22301-942 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:DC2B1F5FC06B8B2C|rigid:BfDV5ANbCnWScKYMfNi4ILghlVs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q6PK50 intact:EBI-1640450 intact:EBI-9356629 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376754|imex:IM-22301-943 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:6A0D918A6858F30E|rigid:/zwnt4g2j0ge4H+WIlliHUdArUg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q99615 intact:EBI-1640450 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376776|imex:IM-22301-944 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:33FFCA8C99B4B1BA|rigid:3DNiUCrth1tENv2ZBQrWa1M/Yzs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q6FHM2 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1640450 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376798|imex:IM-22301-945 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:9D014419D8FBEC26|rigid:JjAPR0lqjVYQ3ewSKyLf3RN9Qps false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q9UHV9 intact:EBI-1640450 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376817|imex:IM-22301-946 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:47924F454C4303E8|rigid:XxLPgCmqVYu5VMvPi2igjfzZLXM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q6FHM2 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1640450 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376837|imex:IM-22301-947 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:221EC2B117D8FEAD|rigid:gFmJykpxmgQ9OCgMH1g/vELd4Yc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q13200 intact:EBI-1640450 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376856|imex:IM-22301-948 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:B1EA135557D42B22|rigid:VBVqU36wX5+FydFEW2dbjve9V6c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q6FHM2 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-1640450 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376878|imex:IM-22301-949 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:A82829474518DFDF|rigid:sK2xvL3UWJNMSJOtXtkBvtthxMM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q96BE0 intact:EBI-1640450 intact:EBI-9356686 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376899|imex:IM-22301-950 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:33BA33EC0365EDB9|rigid:zAf+ACO+VxKGvKxK9/TZ2wFakWg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:P31948 intact:EBI-1640450 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376921|imex:IM-22301-951 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:958D19268DE15ADF|rigid:+AbNPSlivZ2VB7s7qEbcqk0Fqts false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q6FHM2 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-1640450 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376940|imex:IM-22301-952 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:B19D03849A4D5D49|rigid:GDiN1D8lPb+IYos1pSiohFrTAK0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHM2 uniprotkb:Q99471 intact:EBI-1640450 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376959|imex:IM-22301-953 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:EE1E5D200614572C|rigid:9K1c2tvAv2e9q0DgiW+k97xY1eU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q6FHM2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-1640450 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q6fhm2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:hCG_20449(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9376978|imex:IM-22301-954 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_005264.2|dip:DIP-600N|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q6FHM2(identity)|human orfeome collection:6885(identity)|ddbj/embl/genbank:BC010073(identity)|entrezgene/locuslink:2783(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:101C516EA361397B|rigid:Lw/IcHao4xrgx2q/H7lyesEKDvw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6FHN3 uniprotkb:Q03933 intact:EBI-9377000 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q6fhn3_human(display_long)|uniprotkb:NME2(gene name)|psi-mi:NME2(display_short)|uniprotkb:HEL-S-155an(gene name synonym)|uniprotkb:hCG_2001850(orf name) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377004|imex:IM-22301-955 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR034907|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|refseq:NP_001018147.1|refseq:NP_001018148.1|refseq:NP_001018149.1|refseq:NP_002503.1|interpro:IPR036850|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005882"(intermediate filament)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|uniprotkb:Q6FHN3(identity)|entrezgene/locuslink:4831(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GHHfoXOuc25KIJJqiW9r+OWm5Kk9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:91B8BE497562F533|rigid:KVrws9yWtwmIwdIpE1x2PQD+c9k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q6FHN3 intact:EBI-9356686 intact:EBI-9377000 psi-mi:q96be0_human(display_long) psi-mi:q6fhn3_human(display_long)|uniprotkb:NME2(gene name)|psi-mi:NME2(display_short)|uniprotkb:HEL-S-155an(gene name synonym)|uniprotkb:hCG_2001850(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377021|imex:IM-22301-956 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR034907|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|refseq:NP_001018147.1|refseq:NP_001018148.1|refseq:NP_001018149.1|refseq:NP_002503.1|interpro:IPR036850|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005882"(intermediate filament)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|uniprotkb:Q6FHN3(identity)|entrezgene/locuslink:4831(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:GHHfoXOuc25KIJJqiW9r+OWm5Kk9606 intact-crc:423462B555C7E139|rigid:AOjcq8GQbSb+QAzJcQmDAfYMl0U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q6GZ88 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9377041 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q6gz88_human(display_long)|uniprotkb:NR1I3(gene name)|psi-mi:NR1I3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377045|imex:IM-22301-957 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) uniprotkb:Q6GZ88(identity)|human orfeome collection:13990(identity)|ddbj/embl/genbank:BC069626(identity)|entrezgene/locuslink:9970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:uI5gK6yl2XGtDZmZgU7VOqPdpHY9606 intact-crc:4D7A20D4A6D7C0AE|rigid:iU/OiWpv0Ilv9wukbXuVYPPZriU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q6GZ88 intact:EBI-9357028 intact:EBI-9377041 psi-mi:b4dyc6_human(display_long) psi-mi:q6gz88_human(display_long)|uniprotkb:NR1I3(gene name)|psi-mi:NR1I3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377066|imex:IM-22301-958 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) uniprotkb:Q6GZ88(identity)|human orfeome collection:13990(identity)|ddbj/embl/genbank:BC069626(identity)|entrezgene/locuslink:9970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:uI5gK6yl2XGtDZmZgU7VOqPdpHY9606 intact-crc:9734CEAAAF7C4F7F|rigid:uJJ7ln1WBWouO2zD0aqm484JyQw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6GZ88 uniprotkb:Q16543 intact:EBI-9377041 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q6gz88_human(display_long)|uniprotkb:NR1I3(gene name)|psi-mi:NR1I3(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377086|imex:IM-22301-959 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6GZ88(identity)|human orfeome collection:13990(identity)|ddbj/embl/genbank:BC069626(identity)|entrezgene/locuslink:9970(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uI5gK6yl2XGtDZmZgU7VOqPdpHY9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:AAF0EA577BE0784E|rigid:g/R9iKihj8llwGt1OXEXw7A26lI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q6IAW5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9377109 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q6iaw5_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:hCG_41656(orf name)|uniprotkb:tcag7.422(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377106|imex:IM-22301-960 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|refseq:NP_001210.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q6IAW5(identity)|human orfeome collection:5924(identity)|ddbj/embl/genbank:BC013383(identity)|entrezgene/locuslink:813(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 intact-crc:17F090E1A31EF0DB|rigid:33dlS10CrgB0NbiqtFRDf7lK0l4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6IAW5 uniprotkb:P58340 intact:EBI-9377109 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q6iaw5_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:hCG_41656(orf name)|uniprotkb:tcag7.422(orf name) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377129|imex:IM-22301-961 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|refseq:NP_001210.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q6IAW5(identity)|human orfeome collection:5924(identity)|ddbj/embl/genbank:BC013383(identity)|entrezgene/locuslink:813(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:C9C41F492FE20FBC|rigid:jTNKP4Zx33v5ne9dTwsRvTe3OGw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6IAW5 uniprotkb:Q8WW22 intact:EBI-9377109 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 psi-mi:q6iaw5_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:hCG_41656(orf name)|uniprotkb:tcag7.422(orf name) psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377151|imex:IM-22301-962 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|refseq:NP_001210.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q6IAW5(identity)|human orfeome collection:5924(identity)|ddbj/embl/genbank:BC013383(identity)|entrezgene/locuslink:813(identity) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 intact-crc:006243F29DD48E19|rigid:/NCue0i92Fei9B9450FqY8pQtS8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6IAW5 uniprotkb:Q15773 intact:EBI-9377109 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q6iaw5_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:hCG_41656(orf name)|uniprotkb:tcag7.422(orf name) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377173|imex:IM-22301-963 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|refseq:NP_001210.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q6IAW5(identity)|human orfeome collection:5924(identity)|ddbj/embl/genbank:BC013383(identity)|entrezgene/locuslink:813(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:E5A257B31B15A096|rigid:cFR0r1VFOcLr49YeCxMupp34rJ8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q6IAX9 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9377198 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q6iax9_human(display_long)|uniprotkb:SRPR(gene name)|psi-mi:SRPR(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377195|imex:IM-22301-964 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) interpro:IPR042101|interpro:IPR000897(Signal recognition particle, SRP54 subunit, GTPase)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007222(Signal recognition particle receptor, alpha subunit, N-terminal)|interpro:IPR011012(Longin-like)|interpro:IPR013822(Signal recognition particle, SRP54 subunit, helical bundle)|interpro:IPR027417|interpro:IPR036225|go:"GO:0003924"(GTPase activity)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|uniprotkb:Q6IAX9(identity)|entrezgene/locuslink:6734(identity)|human orfeome collection:411(identity)|ddbj/embl/genbank:BC001162(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:i5XIznACfXfJKLW2hBieI4jCrtg9606 intact-crc:574895F2042D4911|rigid:WvTqAGz1cYUGJ54+Umi7INgp3g0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q6IBR0 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9377221 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q6ibr0_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377218|imex:IM-22301-965 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR007676(Ribophorin I)|go:"GO:0006486"(protein glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q6IBR0(identity)|entrezgene/locuslink:6184(identity)|ddbj/embl/genbank:BC010839(identity)|human orfeome collection:2423(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:HMYIu/5zfLkIv7u6nMVRDBfmXUc9606 intact-crc:35054E721F5BEFDE|rigid:MLOeWQKufQeSO4VXPMI1sRJh/jE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ICN0 uniprotkb:P22681 intact:EBI-9377244 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 psi-mi:q6icn0_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short) psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377248|imex:IM-22301-966 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035641|interpro:IPR035643|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR036028|interpro:IPR036860|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|uniprotkb:Q6ICN0(identity)|ddbj/embl/genbank:BC000631(identity)|human orfeome collection:8010(identity)|entrezgene/locuslink:2885(identity) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8HZM/bi2rk2ORgRjpFiEevMd9bM9606 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 intact-crc:4278B84E4CE7128F|rigid:RhP3a6GGbeFGwsZf3YBax5NGUlU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q6LC83 intact:EBI-9356629 intact:EBI-9377271 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q6lc83_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:hCG_40151(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377268|imex:IM-22301-967 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q6LC83(identity)|ddbj/embl/genbank:BC003644(identity)|human orfeome collection:4019(identity)|entrezgene/locuslink:1019(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:fNDCK/tcih9Earqar5NESuBsq5w9606 intact-crc:D2F30CEBF14B5306|rigid:ndY27mUJWN0ngWTrfS0jhlqfDAo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q6LC83 intact:EBI-9357141 intact:EBI-9377271 psi-mi:q9hav2_human(display_long) psi-mi:q6lc83_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:hCG_40151(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377294|imex:IM-22301-968 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q6LC83(identity)|ddbj/embl/genbank:BC003644(identity)|human orfeome collection:4019(identity)|entrezgene/locuslink:1019(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:fNDCK/tcih9Earqar5NESuBsq5w9606 intact-crc:88D78E38E93FB87E|rigid:WDJ1p3Q3vhT89+ZWZBM+XVikt7A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6LC83 uniprotkb:Q16543 intact:EBI-9377271 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q6lc83_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:hCG_40151(orf name) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377316|imex:IM-22301-969 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q6LC83(identity)|ddbj/embl/genbank:BC003644(identity)|human orfeome collection:4019(identity)|entrezgene/locuslink:1019(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fNDCK/tcih9Earqar5NESuBsq5w9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:3E3CD2033971B802|rigid:r917dF2CkLjL22VR7VO447yPIG0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6LC83 uniprotkb:Q9UNE7 intact:EBI-9377271 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:q6lc83_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:hCG_40151(orf name) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377336|imex:IM-22301-970 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q6LC83(identity)|ddbj/embl/genbank:BC003644(identity)|human orfeome collection:4019(identity)|entrezgene/locuslink:1019(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fNDCK/tcih9Earqar5NESuBsq5w9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:B1835FFAF9B3C60C|rigid:JnvncpyDHNoCE+VdEpA3TgkMFys false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6N074 uniprotkb:Q9H6T3 intact:EBI-9377358 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:q6n074_human(display_long)|uniprotkb:DKFZp686N224(gene name)|psi-mi:DKFZp686N224(display_short) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377362|imex:IM-22301-971 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031047|interpro:IPR027417|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043044"|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0006351"(transcription, DNA-templated)|uniprotkb:Q6N074(identity)|entrezgene/locuslink:54617(identity)|ddbj/embl/genbank:BC146785(identity)|human orfeome collection:72161(identity) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CU8YiKt2TiHrAu2nYGJDLwhy7o89606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 intact-crc:081673662A752FF8|rigid:86HQOi98lPXvY7qrH0tkz4AVdZU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NSI4 uniprotkb:Q8IVD9 intact:EBI-8634209|ensembl:ENSP00000361628|uniprotkb:Q9H7W5|uniprotkb:Q6PHY5|uniprotkb:Q6PII9|intact:MINT-8162145|uniprotkb:Q9NWA6|uniprotkb:Q5JQS1|uniprotkb:Q4G0L7|uniprotkb:H7BY89|uniprotkb:Q5JRF9|uniprotkb:Q6PJU8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:radx_human(display_long)|uniprotkb:RADX(gene name)|psi-mi:RADX(display_short)|uniprotkb:CXorf57(gene name synonym)|uniprotkb:RPA-related and RAD51-antagonist, X-chromosome(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377384|imex:IM-22301-972 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147231(gene)|ensembl:ENST00000372548(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005657"(replication fork)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR040893|refseq:NP_060485.4|refseq:NP_001171711.1|uniprotkb:Q6NSI4(identity)|entrezgene/locuslink:55086(identity)|ddbj/embl/genbank:BC070110(identity)|human orfeome collection:14450(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) comment:mint - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pUlTaH5Wq19LDuJp7qGlWFpa0q09606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:B3EEF5066AD4BB71|rigid:JWrKkIpjSHzEzkRjIZTRRvUizyk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P52292 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-349938|uniprotkb:Q9BRU5|ensembl:ENSP00000504685|intact:EBI-28977049|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|uniprotkb:B9EJD6|uniprotkb:Q53YE3|intact:EBI-9377406|uniprotkb:Q6NVW7 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ima1_human(display_long)|uniprotkb:KPNA2(gene name)|psi-mi:KPNA2(display_short)|uniprotkb:RCH1(gene name synonym)|uniprotkb:SRP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-2(gene name synonym)|uniprotkb:SRP1-alpha(gene name synonym)|uniprotkb:RAG cohort protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377403|imex:IM-22301-973 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_002257.1|refseq:NP_001307540.1|ensembl:ENST00000330459(transcript)|ensembl:ENST00000537025(transcript)|ensembl:ENST00000579754(transcript)|ensembl:ENST00000584026(transcript)|ensembl:ENST00000677086(transcript)|ensembl:ENST00000679078(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043657"(host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:0098892"(extrinsic component of postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903902"(positive regulation of viral life cycle)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52292|rcsb pdb:1EFX|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:3FEX|ensembl:ENSG00000182481(gene)|rcsb pdb:3FEY|rcsb pdb:3WPT|rcsb pdb:4E4V|rcsb pdb:4WV6|rcsb pdb:5H43|rcsb pdb:7N8J|reactome:R-HSA-111932|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-442729|reactome:R-HSA-5693548|reactome:R-HSA-9018519|ensembl:ENSP00000332455|ensembl:ENSP00000438483|ensembl:ENSP00000462331|ensembl:ENSP00000463602|ensembl:ENSP00000504655|ensembl:ENSP00000504685|dip:DIP-6205N|uniprotkb:Q6NVW7(identity)|entrezgene/locuslink:3838(identity)|ddbj/embl/genbank:BC005978(identity)|human orfeome collection:5809(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/05/26 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:DFtAbvPxkzWJO/fRLPGxA6pEEJQ9606 intact-crc:A0D27FA9543F9ED2|rigid:VhTbKcX3GzDgiFY8EORKAED41QM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P158 uniprotkb:Q13451 intact:EBI-1051531|uniprotkb:Q53SI4|uniprotkb:Q6P9G1|uniprotkb:Q7Z6H3|uniprotkb:Q8NG17|uniprotkb:Q96M33|uniprotkb:A2RRC7|ensembl:ENSP00000405111 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:dhx57_human(display_long)|uniprotkb:DEAH box protein 57(gene name synonym)|uniprotkb:DHX57(gene name)|psi-mi:DHX57(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377428|imex:IM-22301-974 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_945314.1|refseq:XP_011531456.1|refseq:XP_011531457.1|ensembl:ENSG00000163214(gene)|ensembl:ENST00000457308(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR006575(RWD)|interpro:IPR007502(Helicase-associated region)|interpro:IPR009060(UBA-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR027417|interpro:IPR036855|interpro:IPR041367|interpro:IPR042615|mint:Q6P158|uniprotkb:Q6P158(identity)|entrezgene/locuslink:90957(identity)|ddbj/embl/genbank:BC131534(identity)|human orfeome collection:56336(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+srrYp6+3YKAvSOr8wkq0Vcjsvo9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:9696146D2C49E6B1|rigid:p3v2fNg3LpUD0usF0FPITEfQ4D0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:P07900 intact:EBI-9356629 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377447|imex:IM-22301-975 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:31560450B26AEAE3|rigid:lw/M3pEbo57+nghkadgyfhluink false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q7L3B6 intact:EBI-9356629 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377468|imex:IM-22301-976 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 intact-crc:2C61464D5D1D1495|rigid:AWyf9DjGR1dRAxKk+Z2YVSDX8v0 false flag tag:n-n("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PKC8 uniprotkb:Q96RS6 intact:EBI-9377490 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:q6pkc8_human(display_long)|uniprotkb:DHX16(gene name)|psi-mi:DHX16(display_short) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377494|imex:IM-22301-977 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6PKC8(identity)|human orfeome collection:4899(identity)|entrezgene/locuslink:8449(identity)|ddbj/embl/genbank:BC008825(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a2tnbykyWQOyJGKqg8VgTZBg7KE9606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:C55B4C8C72D69B1C|rigid:qg2gIUFYy0zil3yc18KRNOVJIbY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:Q13451 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377513|imex:IM-22301-978 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:54B0D6AFCFB05BCA|rigid:MU3n+i7bFl+kjSAEPE/iY/gHtEY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:Q6PK50 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-9356629 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377532|imex:IM-22301-979 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:C2F0BB1ED4F6A8D8|rigid:6Ip/aH/cGAWl52Wd3p8Q9DYoWek false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:B4DYC6 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-9357028 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377554|imex:IM-22301-980 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:835ED107B7CFD91B|rigid:oBbDeQ1rU2CzZCtiRiRp7nv3heY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:Q96BE0 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-9356686 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377574|imex:IM-22301-981 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:2BC352B76450B6CE|rigid:Tf5X9m2kL5+f03P4FwI2+bWKMJA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:P07900 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377596|imex:IM-22301-982 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:0E89E7C3305C899E|rigid:OBWoApvTRS+GnvlFRkLCj6lF0eM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:Q16543 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377617|imex:IM-22301-983 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:6D8EEED23C5B84C8|rigid:ztiR/ePyoWcAJ2M1+SWAk6/txWg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:O75344 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377637|imex:IM-22301-984 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 intact-crc:9892146FAF508882|rigid:aNFL/fJqkEr921mdWqV4LVDmfac false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VAB6 uniprotkb:Q9BPW0 intact:EBI-6424389|ensembl:ENSP00000339952|uniprotkb:A0PJT2|uniprotkb:Q3B828|uniprotkb:Q8N775 intact:EBI-9356778 psi-mi:ksr2_human(display_long)|uniprotkb:KSR2(gene name)|psi-mi:KSR2(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377659|imex:IM-22301-985 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171435(gene)|ensembl:ENST00000339824(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR025561|rcsb pdb:2Y4I|rcsb pdb:5KKR|rcsb pdb:7JUQ|rcsb pdb:7JUR|rcsb pdb:7JUS|rcsb pdb:7JUT|rcsb pdb:7JUU|rcsb pdb:7JUV|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_011536527.1|refseq:NP_775869.3|dip:DIP-59195N|uniprotkb:Q6VAB6(identity)|human orfeome collection:55965(identity)|ddbj/embl/genbank:BC127603(identity)|entrezgene/locuslink:283455(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:OlI4pDl6WcP83TUtvsTEf7DVbkM9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:2D270D0A544DFE43|rigid:qwMwH/+AUchGqsIcfDTQQsy0hjw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VVB1 uniprotkb:Q6PK50 intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1 intact:EBI-9356629 psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377681|imex:IM-22301-986 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2|uniprotkb:Q6VVB1(identity)|ddbj/embl/genbank:BC103888(identity)|human orfeome collection:52819(identity)|entrezgene/locuslink:378884(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:B7048BC2593C86C5|rigid:UHxm7Uky4/hC9dZxiRwFinlghj0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VVB1 uniprotkb:Q9Y266 intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377703|imex:IM-22301-987 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2|uniprotkb:Q6VVB1(identity)|ddbj/embl/genbank:BC103888(identity)|human orfeome collection:52819(identity)|entrezgene/locuslink:378884(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:88C0B8F3C76D0551|rigid:sknS0SM2vCkNu0pPZwQTYJUqMLE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VVB1 uniprotkb:Q8IVD9 intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377722|imex:IM-22301-988 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2|uniprotkb:Q6VVB1(identity)|ddbj/embl/genbank:BC103888(identity)|human orfeome collection:52819(identity)|entrezgene/locuslink:378884(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:D41CD5C1BDFD254B|rigid:DdZHzFvSnKnhuNA7N5oZXE4e0gA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6VVB1 uniprotkb:Q96BE0 intact:EBI-6426628|ensembl:ENSP00000345464|uniprotkb:Q6IMH1|uniprotkb:Q5VUK7|uniprotkb:Q3SYB1 intact:EBI-9356686 psi-mi:nhlc1_human(display_long)|uniprotkb:NHLRC1(gene name)|psi-mi:NHLRC1(display_short)|uniprotkb:EPM2B(gene name synonym)|uniprotkb:Malin(gene name synonym)|uniprotkb:NHL repeat-containing protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NHLRC1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377741|imex:IM-22301-989 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000187566(gene)|ensembl:ENST00000340650(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013017(NHL repeat, subgroup)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-3322077|reactome:R-HSA-3785653|refseq:NP_940988.2|uniprotkb:Q6VVB1(identity)|ddbj/embl/genbank:BC103888(identity)|human orfeome collection:52819(identity)|entrezgene/locuslink:378884(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jLFXF8B5yGb+VWcX1MkEFOm8hUU9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:52AEEAA32D51921A|rigid:MNOOi3KUPVvRni7sL7mb+ZXy2Uw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:P41587 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9377763|uniprotkb:Q13053|uniprotkb:Q15870|uniprotkb:Q53Y09|uniprotkb:Q6ZN22|uniprotkb:Q9UCW0|ensembl:ENSP00000262178 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:vipr2_human(display_long)|uniprotkb:VIPR2(gene name)|psi-mi:VIPR2(display_short)|uniprotkb:Helodermin-preferring VIP receptor(gene name synonym)|uniprotkb:Pituitary adenylate cyclase-activating polypeptide type III receptor(gene name synonym)|uniprotkb:VIP2R(gene name synonym)|uniprotkb:VPAC2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377767|imex:IM-22301-990 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001291451.1|refseq:NP_001295188.1|refseq:NP_003373.2|ensembl:ENSG00000106018(gene)|ensembl:ENST00000262178(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004999"(vasoactive intestinal polypeptide receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001571(GPCR, family 2, vasoactive intestinal peptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002284(GPCR, family 2, vasoactive intestinal peptide receptor 2)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2X57|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|uniprotkb:Q6ZN22(identity)|ddbj/embl/genbank:BC010569(identity)|human orfeome collection:2889(identity)|entrezgene/locuslink:7434(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:CfK7ZtUitmfsOTS8ibtRTtdwISg9606 intact-crc:7003F73139D06806|rigid:EDxafCCsjh+qGKwf+lDrh2GZwrA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q6ZNJ8 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9377788 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q6znj8_human(display_long)|uniprotkb:FLJ00321(gene name)|psi-mi:FLJ00321(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377792|imex:IM-22301-991 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR038904|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|uniprotkb:Q6ZNJ8(identity)|entrezgene/locuslink:221927(identity)|human orfeome collection:7570(identity)|ddbj/embl/genbank:BC015632(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:b209MKSATLnC7V8Pr630A5QZ4q49606 intact-crc:9E7FE65F3695CD03|rigid:MTiOSP+kDQi2Rx9wjQP8epTf52c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q6ZNJ8 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9377788 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q6znj8_human(display_long)|uniprotkb:FLJ00321(gene name)|psi-mi:FLJ00321(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377813|imex:IM-22301-992 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR038904|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|uniprotkb:Q6ZNJ8(identity)|entrezgene/locuslink:221927(identity)|human orfeome collection:7570(identity)|ddbj/embl/genbank:BC015632(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:b209MKSATLnC7V8Pr630A5QZ4q49606 intact-crc:8B5F9D069FDAB9D4|rigid:A4df9jwRgxjn/bAcASl76ckSUjo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZUC8 uniprotkb:Q9HAV2 intact:EBI-9377838 intact:EBI-9357141 psi-mi:q6zuc8_human(display_long) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377835|imex:IM-22301-993 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6ZUC8(identity)|ddbj/embl/genbank:BC039817(identity)|human orfeome collection:11315(identity)|entrezgene/locuslink:5976(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:MjgWD8iJw4sAIPCRirQW8C3cnMc9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:3C69B548D27BC6D2|rigid:TnXdgduNVjK70zdIFvhPVeQ8LsA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZUC8 uniprotkb:Q9BPW0 intact:EBI-9377838 intact:EBI-9356778 psi-mi:q6zuc8_human(display_long) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377860|imex:IM-22301-994 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6ZUC8(identity)|ddbj/embl/genbank:BC039817(identity)|human orfeome collection:11315(identity)|entrezgene/locuslink:5976(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:MjgWD8iJw4sAIPCRirQW8C3cnMc9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:F9623787ADECB6C8|rigid:1zurtvp0HTeCnBaRB59PB5DaOkc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q70CQ1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377882|imex:IM-22301-995 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:B8057F86D4ADC7E4|rigid:Vnj/CKT8pEECS66cHVwYwnb78+c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q70CQ1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377901|imex:IM-22301-996 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:2DF46E2080D687EE|rigid:mFHiecJf4gPoVa/+W6OYWuSPc+g false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q70CQ1 intact:EBI-9356629 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377922|imex:IM-22301-997 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:AE66DD0F8DC150BA|rigid:r8DHnwbx11xnT96lI574iZ0IGgc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:Q03933 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377944|imex:IM-22301-998 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:F6E208E42BDBBA6C|rigid:8SgwMfZPWhmOkXlkfekOa7rGtXI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q70CQ1 intact:EBI-9357141 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:q9hav2_human(display_long) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377963|imex:IM-22301-999 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:0662BA861D83E008|rigid:ThOCbhLf/bZSbLfvwKct7TWk7jc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:Q8IVD9 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9377985|imex:IM-22301-1000 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:3D291F2F558AEA32|rigid:9wHJp++SAnH3dSQlMmyG/lq0fes false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q70CQ1 intact:EBI-9357028 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:b4dyc6_human(display_long) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378004|imex:IM-22301-1001 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:69434B9664B8BBD1|rigid:94HeOVj4g3tfmQ245soa9BcwgVY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q70CQ1 intact:EBI-9356686 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:q96be0_human(display_long) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378024|imex:IM-22301-1002 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:FECCF17594C56934|rigid:3BGyqS/kIoZv1/d2Y0zZ+UtJWS0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:P07900 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378046|imex:IM-22301-1003 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:27FBB5A234567042|rigid:1o2l4kTGWPCtmsS/Wf5ProXul9Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q70CQ1 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378067|imex:IM-22301-1004 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:0859620FB18A3123|rigid:u3r5hxLO3//Zn9kfOlNlBoPIW8w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75344 uniprotkb:Q70CQ1 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378087|imex:IM-22301-1005 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:8C9E83DA2D81796D|rigid:WsJU6KkwBamFrPQ5wpF3uYSlLh4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:Q15185 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378150|imex:IM-22301-1008 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:DE652817B8337F66|rigid:TBftkKwVbz06jr42a4/ZZDeYLBo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q70CQ1 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378109|imex:IM-22301-1006 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:02227AAE50965B96|rigid:ss7sva09ZbKoIRqg9b02+EnUQ2w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:Q9HB71 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378131|imex:IM-22301-1007 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:4EA2A027B8C49D57|rigid:kL3hqk2j8GGEBa8d9m95b11jARA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q716A7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9378214 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q716a7_human(display_long)|uniprotkb:OPRM1(gene name)|psi-mi:OPRM1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378218|imex:IM-22301-1011 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) uniprotkb:Q716A7(identity)|human orfeome collection:71567(identity)|ddbj/embl/genbank:BC074927(identity)|entrezgene/locuslink:4988(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:vLaN5WmkM7azjI6mZAeAb63RHIM9606 intact-crc:4A6150FD95F98C2A|rigid:ZmSmnk45gJBz9Vvt0dxIOFLfZgo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q70CQ1 uniprotkb:Q9BTE6-2 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378170|imex:IM-22301-1009 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:15D6EA269A62243D|rigid:1hYHfkxAherh7iG52giq84NkIH0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q70CQ1 intact:EBI-9356778 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378192|imex:IM-22301-1010 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2|uniprotkb:Q70CQ1(identity)|human orfeome collection:7353(identity)|ddbj/embl/genbank:BC014176(identity)|entrezgene/locuslink:25862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:6C6FF47554C57330|rigid:tgEUEI0LosZTzBRPJikEtetkwHs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q76GR4 uniprotkb:P58340 intact:EBI-9378239 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q76gr4_human(display_long)|uniprotkb:LIG1(gene name)|psi-mi:LIG1(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378243|imex:IM-22301-1012 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016874"(ligase activity)|uniprotkb:Q76GR4(identity)|entrezgene/locuslink:3978(identity)|human orfeome collection:71458(identity)|ddbj/embl/genbank:BC108318(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fSMLNB9ueA7WIlq5GH1tCjqMsxU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:84DE983B67BF8EF3|rigid:Y0Hy28aRmZPLqPhMWZiX7esOGy8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L3B6 uniprotkb:P31948 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378330|imex:IM-22301-1016 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:45B1B2A033CFD2A6|rigid:NS/DpG8YUEgcv82oHHLdZCxzrSQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q76GR4 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9378239 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q76gr4_human(display_long)|uniprotkb:LIG1(gene name)|psi-mi:LIG1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378265|imex:IM-22301-1013 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) go:"GO:0016874"(ligase activity)|uniprotkb:Q76GR4(identity)|entrezgene/locuslink:3978(identity)|human orfeome collection:71458(identity)|ddbj/embl/genbank:BC108318(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:fSMLNB9ueA7WIlq5GH1tCjqMsxU9606 intact-crc:A286094AEDF5FC19|rigid:LMx6KZx5fnINDNsqZ8y2Lsh3Htg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q7L3B6 intact:EBI-9356629 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378287|imex:IM-22301-1014 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 intact-crc:11CF016F37CA92CB|rigid:AWyf9DjGR1dRAxKk+Z2YVSDX8v0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q7L3B6 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378309|imex:IM-22301-1015 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 intact-crc:4E2D4A16BE85A3D9|rigid:hZt3mUkUragDV8v3Jj3OHXsFMhQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q7L576 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378392|imex:IM-22301-1019 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N|uniprotkb:Q7L576(identity)|entrezgene/locuslink:23191(identity)|human orfeome collection:5025(identity)|ddbj/embl/genbank:BC005097(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 intact-crc:C3536C0A7B20BB41|rigid:uu0MCW2dn76Wk7JHpLD54MhaBeU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q7L576 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378349|imex:IM-22301-1017 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N|uniprotkb:Q7L576(identity)|entrezgene/locuslink:23191(identity)|human orfeome collection:5025(identity)|ddbj/embl/genbank:BC005097(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 intact-crc:37A5BC6B7C624F87|rigid:Q22z9diGsUuvXLN1XVMhSXuYmhs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L576 uniprotkb:Q15773 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378370|imex:IM-22301-1018 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N|uniprotkb:Q7L576(identity)|entrezgene/locuslink:23191(identity)|human orfeome collection:5025(identity)|ddbj/embl/genbank:BC005097(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:AC12518D9BE5FAA4|rigid:xJZUbZfKu48yH3KBHEvUjntJ/ic false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q7L5D6 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378455|imex:IM-22301-1022 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:02B9B16A8F9E5ED5|rigid:lIa9WfLFp4EsztNU936pbe35JYo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q7L576 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-1048143|uniprotkb:Q14467|uniprotkb:Q5IED0|uniprotkb:Q6ZSX1|uniprotkb:Q9BSD9|uniprotkb:Q9BVC7|uniprotkb:A8K6D9|ensembl:ENSP00000478779|ensembl:ENSP00000481038|ensembl:ENSP00000499947|ensembl:ENSP00000500331 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:cyfp1_human(display_long)|uniprotkb:Specifically Rac1-associated protein 1(gene name synonym)|uniprotkb:p140sra-1(gene name synonym)|uniprotkb:CYFIP1(gene name)|psi-mi:CYFIP1(display_short)|uniprotkb:KIAA0068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378414|imex:IM-22301-1020 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_001028200.1|refseq:NP_055423.1|refseq:NP_001274739.1|ensembl:ENSG00000273749(gene)|ensembl:ENSG00000288461(gene)|ensembl:ENST00000610365(transcript)|ensembl:ENST00000617928(transcript)|ensembl:ENST00000671714(transcript)|ensembl:ENST00000672091(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0006417"(regulation of translation)|go:"GO:0007411"(axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031209"(SCAR complex)|go:"GO:0005576"(extracellular region)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032433"(filopodium tip)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0005829"(cytosol)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050890"(cognition)|go:"GO:0051015"(actin filament binding)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060076"(excitatory synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090724"(central region of growth cone)|go:"GO:0090725"(peripheral region of growth cone)|go:"GO:0097484"(dendrite extension)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1903422"(negative regulation of synaptic vesicle recycling)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q7L576|rcsb pdb:3P8C|rcsb pdb:4N78|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9664422|refseq:NP_001311049.1|refseq:NP_001311052.1|dip:DIP-38873N|uniprotkb:Q7L576(identity)|entrezgene/locuslink:23191(identity)|human orfeome collection:5025(identity)|ddbj/embl/genbank:BC005097(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:cEF+RA9JRXz8Mbsl/s89Up2ONRc9606 intact-crc:89F034A25E464B58|rigid:65BAU/+nNKy1lxyCReTFkhEK1VY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5D6 uniprotkb:P58340 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378433|imex:IM-22301-1021 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:AAC1ED9B5F43BAAA|rigid:6Kf/44y6RbhD5BN3112MBmp3d6k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q7L5D6 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378542|imex:IM-22301-1026 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:AA24B41C82FD7D3A|rigid:FZUVwKrLA49mThMsoar7P+5kRSo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5D6 uniprotkb:Q15773 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378476|imex:IM-22301-1023 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:0B848E23C3D7780E|rigid:FQzKLLWzZMWnE5CtCCneFQ+w+uI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5D6 uniprotkb:P04792 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378498|imex:IM-22301-1024 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|entrezgene/locuslink:3315(identity)|ddbj/embl/genbank:BC012292(identity)|human orfeome collection:618(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:F361A852C0FC71EC|rigid:QGD9x99bgHsfNOi58qfRSWF+s24 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q7L5D6 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378520|imex:IM-22301-1025 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|human orfeome collection:3785(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:F3B103579ED55F7A|rigid:LJedG4lFEaIdYTYOItlk1D0zwGg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q9NWG3 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9378605 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:q9nwg3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378602|imex:IM-22301-1029 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) uniprotkb:Q9NWG3(identity)|human orfeome collection:11189(identity)|ddbj/embl/genbank:BC037992(identity)|entrezgene/locuslink:55898(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:pUVn+gV06Z0QldIs4vrzAcRZzvk9606 intact-crc:12242A7FCA8A4067|rigid:4nv7MpQLaIKeMRsSLTRI6VYABIQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q13451 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378561|imex:IM-22301-1027 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:D7DDD546E49E2786|rigid:f0bjKrRemC/2//ufTxNKWD6fKuE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q6PK50 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9356629 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378580|imex:IM-22301-1028 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:E7CDED6BE51AF0C3|rigid:kOMcECc5m/EzyNSAvcdMF2E8jxI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q8IVD9 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378671|imex:IM-22301-1032 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:7A05A73FFAE43055|rigid:vRxfr+4FuCOVbKPeLAp3VsTNjvQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q53FC7 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9356749 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378627|imex:IM-22301-1030 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:FE8BA025BC8FC579|rigid:FmIg2FJIExzEkIpSqFo/fNJ02v0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:O95816 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378649|imex:IM-22301-1031 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:043900C597008854|rigid:e+ZG/CEqnF0tBV+eDaaRg7HG3ps false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q96BE0 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9356686 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378710|imex:IM-22301-1034 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:D27E4E06DEB979AE|rigid:ph5tdpd9q2Twk6yEvFMkPLCckyY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:B4DYC6 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9357028 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378690|imex:IM-22301-1033 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:270362DC04CD8E40|rigid:K3725S7IhZE1hyzmalr6knDmMoc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:P31948 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378732|imex:IM-22301-1035 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:4126346A1668C66F|rigid:CgDW6NnfWPk4/CWT3SnL+Ej9YdE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q9HB71 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378751|imex:IM-22301-1036 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:A540498644DD62D2|rigid:+ifRD356dPhd1MFM/NmoV7yAyRk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q6PK50 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-9356629 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378811|imex:IM-22301-1039 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:BE7C1B41D00686AF|rigid:wEL6D0jQKf2F6/54FWvhjuixE/c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L5Y6 uniprotkb:Q9BTE6-2 intact:EBI-6425391|ensembl:ENSP00000268148|uniprotkb:Q9NWD5|uniprotkb:B3KNN6|uniprotkb:Q2VPC0 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:det1_human(display_long)|uniprotkb:DET1(gene name)|psi-mi:DET1(display_short)|uniprotkb:De-etiolated-1 homolog(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378770|imex:IM-22301-1037 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140543(gene)|ensembl:ENST00000268148(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR019138|reactome:R-HSA-983168|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001308525.1|refseq:NP_001137546.1|refseq:NP_060466.2|uniprotkb:Q7L5Y6(identity)|entrezgene/locuslink:55070(identity)|human orfeome collection:53034(identity)|ddbj/embl/genbank:BC109060(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3iDPQS8qQ0nAg/sKx9PUDYnnu1I9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:7C6E252359F3598E|rigid:YDxO/rc2A9H07+Pm+W4fBYiTymA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q13451 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378792|imex:IM-22301-1038 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:3A64883BD1D5701C|rigid:6Dcb2/Z3w9mYPX0VYtQT2plS3d8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:B4DYC6 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-9357028 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378871|imex:IM-22301-1042 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:47F29B6252B9C72B|rigid:elPagoBzi821vRXJkYsmHK0NYWw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q9Y266 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378833|imex:IM-22301-1040 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:B74447F6B239FB6C|rigid:5COdAL2i5xav/eoOK+BKSgk98RA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q8IVD9 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378852|imex:IM-22301-1041 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:3E436A26A25282B4|rigid:BeNxvJ26+4LdqLn7KYgd9D+LYkg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:O75344 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378934|imex:IM-22301-1045 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 intact-crc:6F2F596F4E676471|rigid:xqSs8c2wWp+oCxYTJtw+oFPFOs4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q96BE0 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-9356686 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378891|imex:IM-22301-1043 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:858C50751DED45B6|rigid:xI3kozMVhvV+YWRG4c8AWNcnAjM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:P07900 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378913|imex:IM-22301-1044 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:FC30BFD8260DF3ED|rigid:Vaw0DKwUihmbCR4EK4RVLcrToKM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q9HB71 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378956|imex:IM-22301-1046 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:12DA100F3998E2A2|rigid:ed3vaJ4slMFM8lG32eS/7dMZQfU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q15185 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378975|imex:IM-22301-1047 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:D8CC170063E650EB|rigid:KBJbXZ83JhLDPHr/Ara/5PSuzNE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z4G2 uniprotkb:Q8IVD9 intact:EBI-9379042 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q7z4g2_human(display_long)|uniprotkb:MST075(gene name)|psi-mi:MST075(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379062|imex:IM-22301-1051 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q7Z4G2(identity)|ddbj/embl/genbank:BC018126(identity)|human orfeome collection:752(identity)|entrezgene/locuslink:6117(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ABGrMEJciM6gMvYJHuI++AMMhDE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:DFE78F8A2B7635AC|rigid:QxPLlLDghD5v8/awR/bWR3QPMXM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q9BTE6-2 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9378995|imex:IM-22301-1048 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:AA4DEBC3258DBF8B|rigid:3Nis6ob761N+qomhjyj2clKZKZc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3Z4 uniprotkb:Q9BPW0 intact:EBI-528601|uniprotkb:Q68CZ4|uniprotkb:Q8N8G9|uniprotkb:Q8N9V8|uniprotkb:Q8NEH2|uniprotkb:B4DEG5|ensembl:ENSP00000299001 intact:EBI-9356778 psi-mi:piwl4_human(display_long)|uniprotkb:PIWIL4(gene name)|psi-mi:PIWIL4(display_short)|uniprotkb:HIWI2(gene name synonym)|uniprotkb:PIWI(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379017|imex:IM-22301-1049 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689644.2|ensembl:ENST00000299001(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071547"(piP-body)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036085|interpro:IPR036397|mint:Q7Z3Z4|reactome:R-HSA-5601884|ensembl:ENSG00000134627(gene)|uniprotkb:Q7Z3Z4(identity)|entrezgene/locuslink:143689(identity)|human orfeome collection:2081(identity)|ddbj/embl/genbank:BC031060(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wcvVa2Z0CqemBieD8X12ovmdfpc9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:EA9D56FE6B312968|rigid:D9FRDUsE4WaZZp1YlnBzqyLij1Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z4G2 uniprotkb:Q13451 intact:EBI-9379042 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q7z4g2_human(display_long)|uniprotkb:MST075(gene name)|psi-mi:MST075(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379039|imex:IM-22301-1050 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q7Z4G2(identity)|ddbj/embl/genbank:BC018126(identity)|human orfeome collection:752(identity)|entrezgene/locuslink:6117(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ABGrMEJciM6gMvYJHuI++AMMhDE9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:C85C788694D7CC05|rigid:vUn2ON73EQI2cahUPpjxFAB089M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z511 uniprotkb:Q9UIM3 intact:EBI-9379128 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:q7z511_human(display_long) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379125|imex:IM-22301-1054 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR033598|interpro:IPR044852|interpro:IPR004182(GRAM)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0071391"(cellular response to estrogen stimulus)|uniprotkb:Q7Z511(identity)|human orfeome collection:2893(identity)|entrezgene/locuslink:23558(identity)|ddbj/embl/genbank:BC007452(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eQHIjtiepdkR/Cp48xHlsZY0q5M9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:A6E80A9DA9BCD2EE|rigid:3PzZnIipi0V8M7+agWCnkGITUVE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z4G2 uniprotkb:Q96BE0 intact:EBI-9379042 intact:EBI-9356686 psi-mi:q7z4g2_human(display_long)|uniprotkb:MST075(gene name)|psi-mi:MST075(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379081|imex:IM-22301-1052 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q7Z4G2(identity)|ddbj/embl/genbank:BC018126(identity)|human orfeome collection:752(identity)|entrezgene/locuslink:6117(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ABGrMEJciM6gMvYJHuI++AMMhDE9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:22CC63ED98A6E5C6|rigid:OePz/Q2AZo1Qwm2QderHFFyG26M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q7Z4G2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9379042 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q7z4g2_human(display_long)|uniprotkb:MST075(gene name)|psi-mi:MST075(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379103|imex:IM-22301-1053 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) uniprotkb:Q7Z4G2(identity)|ddbj/embl/genbank:BC018126(identity)|human orfeome collection:752(identity)|entrezgene/locuslink:6117(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:ABGrMEJciM6gMvYJHuI++AMMhDE9606 intact-crc:EA55BA1A98602F39|rigid:7ZYkma1LGfxoC8ivJnMmPU6BB9c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q7Z6J8 intact:EBI-9356778 intact:EBI-9379147|uniprotkb:B4DP63|uniprotkb:Q75UG0|uniprotkb:Q5T4W2|uniprotkb:Q9NT42|uniprotkb:Q6IPR4|ensembl:ENSP00000358762 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:ube3d_human(display_long)|uniprotkb:UBE3D(gene name)|psi-mi:UBE3D(display_short)|uniprotkb:C6orf157(gene name synonym)|uniprotkb:H10BH(gene name synonym)|uniprotkb:UBE2CBP(gene name synonym)|uniprotkb:UbcH10-binding protein with a HECT-like domain(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2C-binding protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase E3D(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379156|imex:IM-22301-1055 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_001291366.1|refseq:NP_944602.1|ensembl:ENSG00000118420(gene)|ensembl:ENST00000369747(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019193|mint:Q7Z6J8|reactome:R-HSA-983168|uniprotkb:Q7Z6J8(identity)|entrezgene/locuslink:90025(identity)|human orfeome collection:71774(identity)|ddbj/embl/genbank:BC101512(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:F4Rnc9zJhfNndZpYOJ5e5wrqyNY9606 intact-crc:11B02067BA656179|rigid:CCZ70y2ilTejwuWTYC/s9kim2cs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q7Z790 intact:EBI-9356686 intact:EBI-9379181 psi-mi:q96be0_human(display_long) psi-mi:q7z790_human(display_long)|uniprotkb:RAD51L3(gene name)|psi-mi:RAD51L3(display_short)|uniprotkb:hCG_1989222(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379178|imex:IM-22301-1056 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR013632(Rad51, C-terminal)|interpro:IPR020588|interpro:IPR027417|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|uniprotkb:Q7Z790(identity)|human orfeome collection:7201(identity)|ddbj/embl/genbank:BC014422(identity)|entrezgene/locuslink:5892(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:9mmZXYC77rMmndEWGTsAwPYbJgI9606 intact-crc:73FE949F13816818|rigid:0/q81NmLNUu+b87MvxmlYis/ruw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q53FC7 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-9356749 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379269|imex:IM-22301-1060 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:44CEFA9B9FCC7165|rigid:WiztW4Y/Nb2lAnUQ8TfSXWW/ZVg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z790 uniprotkb:Q9BTE6-2 intact:EBI-9379181 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q7z790_human(display_long)|uniprotkb:RAD51L3(gene name)|psi-mi:RAD51L3(display_short)|uniprotkb:hCG_1989222(orf name) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379204|imex:IM-22301-1057 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013632(Rad51, C-terminal)|interpro:IPR020588|interpro:IPR027417|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006281"(DNA repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|uniprotkb:Q7Z790(identity)|human orfeome collection:7201(identity)|ddbj/embl/genbank:BC014422(identity)|entrezgene/locuslink:5892(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9mmZXYC77rMmndEWGTsAwPYbJgI9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:85FD9D721831EFBC|rigid:ihcqkDFx8zPQbw5ESSc/VOTXjtc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:P58340 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379226|imex:IM-22301-1058 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:D4A23F75481A63B9|rigid:D9tE+DMMCXiNdT7tRtnakw7E4kA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q8K2C9 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379248|imex:IM-22301-1059 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 intact-crc:62E4C00A70C9486A|rigid:KrWio1WL5/RLFAaOW5FWLToG8ec false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q16543 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379335|imex:IM-22301-1063 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:610C4036E6A3FE1F|rigid:MAkLcCFLOlJRZ1H6E+eoRRvcpB4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q13200 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379291|imex:IM-22301-1061 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:4AF8527379D62154|rigid:9EOwSRntMyOFgHKl2EZdD41IMJ4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q96BE0 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-9356686 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379313|imex:IM-22301-1062 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:CE617D6FE7B45C14|rigid:WjUmq6+0BmAETi9XMcR7mAvbqzs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86UP8 uniprotkb:Q9BTE6-2 intact:EBI-6425928|uniprotkb:Q86WX4|uniprotkb:B3KUZ2|uniprotkb:Q6NVW2|uniprotkb:Q69G40|uniprotkb:Q8ND85|uniprotkb:Q6EKI9|uniprotkb:Q6EKI8|uniprotkb:Q8NDE5|uniprotkb:A8K5W6|uniprotkb:Q6P7N8|uniprotkb:A0A0A0MSY2|ensembl:ENSP00000406723 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:gtd2a_human(display_long)|uniprotkb:GTF2IRD2(gene name)|psi-mi:GTF2IRD2(display_short)|uniprotkb:GTF2IRD2A(gene name synonym)|uniprotkb:Transcription factor GTF2IRD2-alpha(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379355|imex:IM-22301-1064 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775808.3|refseq:NP_001268376.1|ensembl:ENSG00000196275(gene)|ensembl:ENST00000451013(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036647|interpro:IPR042224|uniprotkb:Q86UP8(identity)|entrezgene/locuslink:84163(identity)|ddbj/embl/genbank:BC067859(identity)|human orfeome collection:14511(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:Zn+Wa+qURGwPRXC44qsYWKS4mFI9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:9E9FFD7C511F1EC1|rigid:/s0GHYSpAQvaZpqoq46+vWtKvog false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:P58340 intact:EBI-9379380 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379377|imex:IM-22301-1065 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:6DFB96FC2549D158|rigid:j60caYmyRZrwvDUKe8RLkdLwc3c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q86WA0 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9379380 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379446|imex:IM-22301-1068 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:A25B41F95010D2C7|rigid:xTF3CqxAKwt1uYZ+1oFIko7Rvp4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q86WA0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9379380 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379403|imex:IM-22301-1066 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:3902E64F5A3A4B43|rigid:+SbnRl0n9sCCwHqjntfpkMwMdT0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q86WA0 intact:EBI-9356629 intact:EBI-9379380 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379424|imex:IM-22301-1067 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:38EC06AB577D93CC|rigid:JQTmIj/t8rMY3v+Ily5d2Pe+QwA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q86WA0 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-9379380 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379526|imex:IM-22301-1072 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:E8B1A85E13AEDB5B|rigid:5CiSePsVaGppG57wDGRAT3CN4AA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:Q8IVD9 intact:EBI-9379380 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379465|imex:IM-22301-1069 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:50AA68E76ACE01E0|rigid:kEmGTGG54JG8ttLteKAaxCgQPVg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q86WA0 intact:EBI-9357028 intact:EBI-9379380 psi-mi:b4dyc6_human(display_long) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379484|imex:IM-22301-1070 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:26FDC6435181E0D9|rigid:Xfg8mmRI3ddMNGBWrBAuAAs6huw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:Q96BE0 intact:EBI-9379380 intact:EBI-9356686 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379504|imex:IM-22301-1071 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:FA5C1CF613B5D6E6|rigid:9Flf59AxlC9endBwKf0epDGWZuU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q86WA0 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-9379380 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379566|imex:IM-22301-1074 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 intact-crc:BF3927DECE035444|rigid:GxccZsDsPg7uNZX4NgxMqMOD0Hs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:P31948 intact:EBI-9379380 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379547|imex:IM-22301-1073 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:62EC303C9B1FA4D1|rigid:OumN74ZFooUpu7LcNGQkvpA6uTk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:Q9BTE6-2 intact:EBI-9379380 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379585|imex:IM-22301-1075 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:50258C3AC187A75F|rigid:1qMDxTEJqP6LcWM9xRFj48hAFdw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WI5 uniprotkb:Q6PK50 intact:EBI-9379629 intact:EBI-9356629 psi-mi:q86wi5_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379633|imex:IM-22301-1077 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q86WI5(identity)|ddbj/embl/genbank:BC027994(identity)|human orfeome collection:9477(identity)|entrezgene/locuslink:8945(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jnzDohJw6851spdyKitfewBICZY9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:1AFA0D73F40509EF|rigid:VvyKxTmgQnQWbK/C79cLAyKfG/0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86WA0 uniprotkb:Q9BPW0 intact:EBI-9379380 intact:EBI-9356778 psi-mi:q86wa0_human(display_long)|uniprotkb:HIG-1(gene name)|psi-mi:HIG-1(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379607|imex:IM-22301-1076 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_694591.2|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q86WA0(identity)|entrezgene/locuslink:122402(identity)|ddbj/embl/genbank:BC128057(identity)|human orfeome collection:56312(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:73tt1Rq4uEnmTNXM1tl6huYj1CM9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:4C6CA33AAB93020A|rigid:P26JwdlKQc0nUglCEXMN+Dx74bY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86X45 uniprotkb:Q53FC7 intact:EBI-9379658|uniprotkb:Q13648|uniprotkb:Q4G183|ensembl:ENSP00000429791|ensembl:ENSP00000484634 intact:EBI-9356749 psi-mi:daa11_human(display_long)|uniprotkb:DNAAF11(gene name)|psi-mi:DNAAF11(display_short)|uniprotkb:LRRC6(gene name synonym)|uniprotkb:LRTP(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 6(gene name synonym)|uniprotkb:Leucine-rich testis-specific protein(gene name synonym)|uniprotkb:Protein tilB homolog(gene name synonym)|uniprotkb:TSLRP(gene name synonym)|uniprotkb:Testis-specific leucine-rich repeat protein(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379655|imex:IM-22301-1078 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001308890.1|refseq:NP_001308891.1|refseq:NP_001308892.1|refseq:NP_001308893.1|refseq:NP_001308894.1|refseq:NP_001308895.1|refseq:NP_036604.2|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR007052(CS domain)|interpro:IPR032675|mint:Q86X45|ensembl:ENSG00000129295(gene)|ensembl:ENST00000519595(transcript)|ensembl:ENST00000620350(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0008584"(male gonad development)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0036159"(inner dynein arm assembly)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0051649"(establishment of localization in cell)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0061458"(reproductive system development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0090651"(apical cytoplasm)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0120229"(protein localization to motile cilium)|uniprotkb:Q86X45(identity)|human orfeome collection:11451(identity)|ddbj/embl/genbank:BC047286(identity)|entrezgene/locuslink:23639(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+KWpDTd1pD7UAK4rVDo5We0inVw9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:BDC5DAFD9B1D1FA7|rigid:z85pafn80JGy7YqdALVDGyeLUTI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86X45 uniprotkb:Q03933 intact:EBI-9379658|uniprotkb:Q13648|uniprotkb:Q4G183|ensembl:ENSP00000429791|ensembl:ENSP00000484634 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:daa11_human(display_long)|uniprotkb:DNAAF11(gene name)|psi-mi:DNAAF11(display_short)|uniprotkb:LRRC6(gene name synonym)|uniprotkb:LRTP(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 6(gene name synonym)|uniprotkb:Leucine-rich testis-specific protein(gene name synonym)|uniprotkb:Protein tilB homolog(gene name synonym)|uniprotkb:TSLRP(gene name synonym)|uniprotkb:Testis-specific leucine-rich repeat protein(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379683|imex:IM-22301-1079 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001308890.1|refseq:NP_001308891.1|refseq:NP_001308892.1|refseq:NP_001308893.1|refseq:NP_001308894.1|refseq:NP_001308895.1|refseq:NP_036604.2|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR007052(CS domain)|interpro:IPR032675|mint:Q86X45|ensembl:ENSG00000129295(gene)|ensembl:ENST00000519595(transcript)|ensembl:ENST00000620350(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0008584"(male gonad development)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0036159"(inner dynein arm assembly)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0051649"(establishment of localization in cell)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0061458"(reproductive system development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0090651"(apical cytoplasm)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0120229"(protein localization to motile cilium)|uniprotkb:Q86X45(identity)|human orfeome collection:11451(identity)|ddbj/embl/genbank:BC047286(identity)|entrezgene/locuslink:23639(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+KWpDTd1pD7UAK4rVDo5We0inVw9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:0214392D2D8A9252|rigid:YoCGEW4GtPneL7Rx/RaeQgd/6uU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q8IWB1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2556412|uniprotkb:Q5JU17|uniprotkb:Q96MS8|uniprotkb:Q9C0A9|uniprotkb:D3DRA5|ensembl:ENSP00000278071|ensembl:ENSP00000337178|ensembl:ENSP00000350915|ensembl:ENSP00000497746 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ipri_human(display_long)|uniprotkb:DANGER(gene name synonym)|uniprotkb:KIAA1754(gene name synonym)|uniprotkb:Protein DANGER(gene name synonym)|uniprotkb:ITPRIP(gene name)|psi-mi:ITPRIP(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379702|imex:IM-22301-1080 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_203755.1|ensembl:ENSG00000148841(gene)|ensembl:ENST00000278071(transcript)|ensembl:ENST00000337478(transcript)|ensembl:ENST00000358187(transcript)|ensembl:ENST00000647721(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR024797|interpro:IPR024810|interpro:IPR026250|refseq:NP_001258941.1|refseq:NP_001258942.1|uniprotkb:Q8IWB1(identity)|human orfeome collection:10395(identity)|entrezgene/locuslink:85450(identity)|ddbj/embl/genbank:BC040536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:wTUAsA+dqm1wkrs9z4E7a4PdcLk9606 intact-crc:EFFE2025AF50F4FB|rigid:SSVIG7KPU89CYv/VDps6Do4jLmg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q8IWB1 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-2556412|uniprotkb:Q5JU17|uniprotkb:Q96MS8|uniprotkb:Q9C0A9|uniprotkb:D3DRA5|ensembl:ENSP00000278071|ensembl:ENSP00000337178|ensembl:ENSP00000350915|ensembl:ENSP00000497746 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:ipri_human(display_long)|uniprotkb:DANGER(gene name synonym)|uniprotkb:KIAA1754(gene name synonym)|uniprotkb:Protein DANGER(gene name synonym)|uniprotkb:ITPRIP(gene name)|psi-mi:ITPRIP(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379744|imex:IM-22301-1082 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_203755.1|ensembl:ENSG00000148841(gene)|ensembl:ENST00000278071(transcript)|ensembl:ENST00000337478(transcript)|ensembl:ENST00000358187(transcript)|ensembl:ENST00000647721(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR024797|interpro:IPR024810|interpro:IPR026250|refseq:NP_001258941.1|refseq:NP_001258942.1|uniprotkb:Q8IWB1(identity)|human orfeome collection:10395(identity)|entrezgene/locuslink:85450(identity)|ddbj/embl/genbank:BC040536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:wTUAsA+dqm1wkrs9z4E7a4PdcLk9606 intact-crc:EC212D38058C44A6|rigid:nFLeutPptAqJB7DUDky0p+o/gPo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWB1 uniprotkb:Q9BPW0 intact:EBI-2556412|uniprotkb:Q5JU17|uniprotkb:Q96MS8|uniprotkb:Q9C0A9|uniprotkb:D3DRA5|ensembl:ENSP00000278071|ensembl:ENSP00000337178|ensembl:ENSP00000350915|ensembl:ENSP00000497746 intact:EBI-9356778 psi-mi:ipri_human(display_long)|uniprotkb:DANGER(gene name synonym)|uniprotkb:KIAA1754(gene name synonym)|uniprotkb:Protein DANGER(gene name synonym)|uniprotkb:ITPRIP(gene name)|psi-mi:ITPRIP(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379763|imex:IM-22301-1083 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203755.1|ensembl:ENSG00000148841(gene)|ensembl:ENST00000278071(transcript)|ensembl:ENST00000337478(transcript)|ensembl:ENST00000358187(transcript)|ensembl:ENST00000647721(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR024797|interpro:IPR024810|interpro:IPR026250|refseq:NP_001258941.1|refseq:NP_001258942.1|uniprotkb:Q8IWB1(identity)|human orfeome collection:10395(identity)|entrezgene/locuslink:85450(identity)|ddbj/embl/genbank:BC040536(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wTUAsA+dqm1wkrs9z4E7a4PdcLk9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:AF25BE82A6830025|rigid:Vhgy1CsPj5ZHt6IIaCWIFkHS+3s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q8IWB1 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-2556412|uniprotkb:Q5JU17|uniprotkb:Q96MS8|uniprotkb:Q9C0A9|uniprotkb:D3DRA5|ensembl:ENSP00000278071|ensembl:ENSP00000337178|ensembl:ENSP00000350915|ensembl:ENSP00000497746 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:ipri_human(display_long)|uniprotkb:DANGER(gene name synonym)|uniprotkb:KIAA1754(gene name synonym)|uniprotkb:Protein DANGER(gene name synonym)|uniprotkb:ITPRIP(gene name)|psi-mi:ITPRIP(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379723|imex:IM-22301-1081 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:NP_203755.1|ensembl:ENSG00000148841(gene)|ensembl:ENST00000278071(transcript)|ensembl:ENST00000337478(transcript)|ensembl:ENST00000358187(transcript)|ensembl:ENST00000647721(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR024797|interpro:IPR024810|interpro:IPR026250|refseq:NP_001258941.1|refseq:NP_001258942.1|uniprotkb:Q8IWB1(identity)|human orfeome collection:10395(identity)|entrezgene/locuslink:85450(identity)|ddbj/embl/genbank:BC040536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:wTUAsA+dqm1wkrs9z4E7a4PdcLk9606 intact-crc:95B8C589F32117E4|rigid:syfQgGWEkjmBPbWakyqky4BhwuA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWD4 uniprotkb:Q6PK50 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 intact:EBI-9356629 psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379785|imex:IM-22301-1084 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:85EB7F13A0D724AD|rigid:zYtfVSg56RE+KLPznkKAA/CUzag false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q8IWD4 intact:EBI-9356749 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 psi-mi:q53fc7_human(display_long) psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379807|imex:IM-22301-1085 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 intact-crc:51B644CD995D138A|rigid:baSUbJTNNBTwyiUOpI21nMeuRdw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWD4 uniprotkb:Q96BE0 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 intact:EBI-9356686 psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379829|imex:IM-22301-1086 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:40731571A7B64781|rigid:kglmZ/EfRNQyWjvXFEa1H3jPa2M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q8IWD4 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379851|imex:IM-22301-1087 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 intact-crc:37AF29DB0F085F55|rigid:ndeJst8QUJjv0I39JhyXEkpK0Uo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWP3 uniprotkb:Q15773 intact:EBI-9379916 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q8iwp3_human(display_long) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379913|imex:IM-22301-1090 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038048"(dynorphin receptor activity)|uniprotkb:Q8IWP3(identity)|entrezgene/locuslink:4986(identity)|ddbj/embl/genbank:BC099912(identity)|human orfeome collection:71335(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:HU4sU7GYYAYYa2GZ6ItVBJThVZw9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:E06436AC87E06CB9|rigid:HKpF+feZFn+TjXWBixMRoTRLTz8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q8IWD4 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379872|imex:IM-22301-1088 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 intact-crc:157CB8E07129724D|rigid:7um+D8yLvFC32ZmaY7xfuXZf0HY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWD4 uniprotkb:B3KTT5 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 intact:EBI-8783896 psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:b3ktt5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379891|imex:IM-22301-1089 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|human orfeome collection:11873(identity)|entrezgene/locuslink:150275(identity) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 intact-crc:51EF679B128BA0A9|rigid:6aDQ5YLlOyyOhAmd8gOLKRBJiuQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWX7 uniprotkb:P07900 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379979|imex:IM-22301-1093 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:54C4E7A57880121D|rigid:o9ZfqobzGO8QqiuPbxkxkaGjx/A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:Q8IWP3 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-9379916 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:q8iwp3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379938|imex:IM-22301-1091 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000452(Kappa opioid receptor)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038048"(dynorphin receptor activity)|uniprotkb:Q8IWP3(identity)|entrezgene/locuslink:4986(identity)|ddbj/embl/genbank:BC099912(identity)|human orfeome collection:71335(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:HU4sU7GYYAYYa2GZ6ItVBJThVZw9606 intact-crc:A539EC562A365BCD|rigid:KOvx8PiuAZYZMQY60uCYW3IsSTs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWX7 uniprotkb:Q6PK50 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-9356629 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9379957|imex:IM-22301-1092 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:2D4D6CF865C58583|rigid:04q+J04sQ8iBwwTrOFlpjXJchNo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95429 uniprotkb:Q8IZD4 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380000|imex:IM-22301-1094 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|human orfeome collection:10517(identity)|ddbj/embl/genbank:BC043437(identity)|entrezgene/locuslink:196513(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 intact-crc:7971B42831ED16EC|rigid:c1w1iVhQ8r35yAVYxxMLUW07HoI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q8IZD4 intact:EBI-9356686 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 psi-mi:q96be0_human(display_long) psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380022|imex:IM-22301-1095 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|human orfeome collection:10517(identity)|ddbj/embl/genbank:BC043437(identity)|entrezgene/locuslink:196513(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 intact-crc:8FD2F3C9D6111728|rigid:seIsySuCVOKM+pLsNClBc5OIzwU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IZN1 uniprotkb:Q9HB71 intact:EBI-9380047 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q8izn1_human(display_long)|uniprotkb:TSSK4(gene name)|psi-mi:TSSK4(display_short)|uniprotkb:hCG_40189(orf name) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380092|imex:IM-22301-1098 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q8IZN1(identity)|ddbj/embl/genbank:BC111088(identity)|human orfeome collection:53076(identity)|entrezgene/locuslink:283629(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ID+5TcVyrwIaWbNnRAqhb0UKUCw9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:21AB63040A06574D|rigid:wadQ1WziPK/gUqifcVXMKfuKRTo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IZN1 uniprotkb:Q13200 intact:EBI-9380047 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q8izn1_human(display_long)|uniprotkb:TSSK4(gene name)|psi-mi:TSSK4(display_short)|uniprotkb:hCG_40189(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380044|imex:IM-22301-1096 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q8IZN1(identity)|ddbj/embl/genbank:BC111088(identity)|human orfeome collection:53076(identity)|entrezgene/locuslink:283629(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ID+5TcVyrwIaWbNnRAqhb0UKUCw9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:5806801E21A4194A|rigid:dSDsXsLWXNByFsUhWJrJa6jhDvA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q8IZN1 intact:EBI-9356686 intact:EBI-9380047 psi-mi:q96be0_human(display_long) psi-mi:q8izn1_human(display_long)|uniprotkb:TSSK4(gene name)|psi-mi:TSSK4(display_short)|uniprotkb:hCG_40189(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380070|imex:IM-22301-1097 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q8IZN1(identity)|ddbj/embl/genbank:BC111088(identity)|human orfeome collection:53076(identity)|entrezgene/locuslink:283629(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ID+5TcVyrwIaWbNnRAqhb0UKUCw9606 intact-crc:EDCF41E7C6513EE5|rigid:zhnoZ3BIqR05h2Zoq7ZFQFeZgwk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IZN1 uniprotkb:Q9BTE6-2 intact:EBI-9380047 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q8izn1_human(display_long)|uniprotkb:TSSK4(gene name)|psi-mi:TSSK4(display_short)|uniprotkb:hCG_40189(orf name) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380111|imex:IM-22301-1099 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q8IZN1(identity)|ddbj/embl/genbank:BC111088(identity)|human orfeome collection:53076(identity)|entrezgene/locuslink:283629(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ID+5TcVyrwIaWbNnRAqhb0UKUCw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:D7055119951D6DAB|rigid:apy6defOalpB+/CerXWvmB/HykQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q13200 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380133|imex:IM-22301-1100 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|ddbj/embl/genbank:BC047685(identity)|human orfeome collection:70396(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:1BD89169231237C7|rigid:wGU6XYKqbshCiR6SkgJvMyOlFdE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q8N1E6 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-6425532|ensembl:ENSP00000344855 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:fxl14_human(display_long)|uniprotkb:FBXL14(gene name)|psi-mi:FBXL14(display_short)|uniprotkb:F-box and leucine-rich repeat protein 14(gene name synonym)|uniprotkb:FBL14(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380194|imex:IM-22301-1103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000171823(gene)|ensembl:ENST00000339235(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689654.1|uniprotkb:Q8N1E6(identity)|ddbj/embl/genbank:BC028132(identity)|human orfeome collection:9492(identity)|entrezgene/locuslink:144699(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:H8Gc4/0VTyLxX8UBNy6g0k5m1Qk9606 intact-crc:F8614519A78BFEBB|rigid:8V5NAJTFTIrg8RT2pXRPnWqrf2I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N165 uniprotkb:Q16543 intact:EBI-6423298|ensembl:ENSP00000363387|ensembl:ENSP00000363389|ensembl:ENSP00000480635|uniprotkb:Q5T2I0|uniprotkb:Q8NDB3|uniprotkb:D3DPK2|uniprotkb:B2R777 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:pdk1l_human(display_long)|uniprotkb:PDIK1L(gene name)|psi-mi:PDIK1L(display_short)|uniprotkb:CLIK1L(gene name synonym)|uniprotkb:PDLIM1-interacting kinase 1-like(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380155|imex:IM-22301-1101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175087(gene)|ensembl:ENST00000374269(transcript)|ensembl:ENST00000374271(transcript)|ensembl:ENST00000619836(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_001230461.1|refseq:NP_001230462.1|refseq:NP_690048.1|refseq:XP_005245800.1|uniprotkb:Q8N165(identity)|entrezgene/locuslink:149420(identity)|ddbj/embl/genbank:BC028713(identity)|human orfeome collection:1613(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YhRAS5HsUv4xI4dXTsExLJBE6o89606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:285169251CEF4786|rigid:yZneWGy5ZoZ/gnXN/EbB4pVleck false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1E6 uniprotkb:Q13451 intact:EBI-6425532|ensembl:ENSP00000344855 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:fxl14_human(display_long)|uniprotkb:FBXL14(gene name)|psi-mi:FBXL14(display_short)|uniprotkb:F-box and leucine-rich repeat protein 14(gene name synonym)|uniprotkb:FBL14(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380175|imex:IM-22301-1102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171823(gene)|ensembl:ENST00000339235(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689654.1|uniprotkb:Q8N1E6(identity)|ddbj/embl/genbank:BC028132(identity)|human orfeome collection:9492(identity)|entrezgene/locuslink:144699(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:H8Gc4/0VTyLxX8UBNy6g0k5m1Qk9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:4E5EDF44893645D0|rigid:1mx2R+l/SKd7SJ8nBU1X7KYASvw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1E6 uniprotkb:Q6PK50 intact:EBI-6425532|ensembl:ENSP00000344855 intact:EBI-9356629 psi-mi:fxl14_human(display_long)|uniprotkb:FBXL14(gene name)|psi-mi:FBXL14(display_short)|uniprotkb:F-box and leucine-rich repeat protein 14(gene name synonym)|uniprotkb:FBL14(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380215|imex:IM-22301-1104 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171823(gene)|ensembl:ENST00000339235(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689654.1|uniprotkb:Q8N1E6(identity)|ddbj/embl/genbank:BC028132(identity)|human orfeome collection:9492(identity)|entrezgene/locuslink:144699(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:H8Gc4/0VTyLxX8UBNy6g0k5m1Qk9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:4C1C213B2602CAFD|rigid:UG+xz0c4BL+PEnB9tbzcwkNdxmc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1E6 uniprotkb:B4DYC6 intact:EBI-6425532|ensembl:ENSP00000344855 intact:EBI-9357028 psi-mi:fxl14_human(display_long)|uniprotkb:FBXL14(gene name)|psi-mi:FBXL14(display_short)|uniprotkb:F-box and leucine-rich repeat protein 14(gene name synonym)|uniprotkb:FBL14(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380237|imex:IM-22301-1105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171823(gene)|ensembl:ENST00000339235(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689654.1|uniprotkb:Q8N1E6(identity)|ddbj/embl/genbank:BC028132(identity)|human orfeome collection:9492(identity)|entrezgene/locuslink:144699(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:H8Gc4/0VTyLxX8UBNy6g0k5m1Qk9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:3564BD8C5635F9E3|rigid:fs+OMtNow7KUN28h0SGVSfC5gGI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N446 uniprotkb:Q6PK50 intact:EBI-6428016|ensembl:ENSP00000322899|ensembl:ENSP00000483573|uniprotkb:A8K4U8 intact:EBI-9356629 psi-mi:zn843_human(display_long)|uniprotkb:ZNF843(gene name)|psi-mi:ZNF843(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380279|imex:IM-22301-1107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176723(gene)|ensembl:ENST00000315678(transcript)|ensembl:ENST00000618063(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001129981.1|uniprotkb:Q8N446(identity)|human orfeome collection:10117(identity)|entrezgene/locuslink:283933(identity)|ddbj/embl/genbank:BC036762(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:c3eKlKJjbrXSMwRucJaKbv5yQQQ9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:79835B5C8BFF897D|rigid:BplgSlCUCl3qGilk/355ViUCGF8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1E6 uniprotkb:Q9BTE6-2 intact:EBI-6425532|ensembl:ENSP00000344855 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:fxl14_human(display_long)|uniprotkb:FBXL14(gene name)|psi-mi:FBXL14(display_short)|uniprotkb:F-box and leucine-rich repeat protein 14(gene name synonym)|uniprotkb:FBL14(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380257|imex:IM-22301-1106 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171823(gene)|ensembl:ENST00000339235(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689654.1|uniprotkb:Q8N1E6(identity)|ddbj/embl/genbank:BC028132(identity)|human orfeome collection:9492(identity)|entrezgene/locuslink:144699(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:H8Gc4/0VTyLxX8UBNy6g0k5m1Qk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:345F732A64BE0E69|rigid:hEjOexBpEs8bovZj3ZMzTjx/alo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N446 uniprotkb:Q16543 intact:EBI-6428016|ensembl:ENSP00000322899|ensembl:ENSP00000483573|uniprotkb:A8K4U8 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:zn843_human(display_long)|uniprotkb:ZNF843(gene name)|psi-mi:ZNF843(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380301|imex:IM-22301-1108 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000176723(gene)|ensembl:ENST00000315678(transcript)|ensembl:ENST00000618063(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:NP_001129981.1|uniprotkb:Q8N446(identity)|human orfeome collection:10117(identity)|entrezgene/locuslink:283933(identity)|ddbj/embl/genbank:BC036762(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:c3eKlKJjbrXSMwRucJaKbv5yQQQ9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:8CCF4A9713473115|rigid:QtsepdZABfPTIbG5aokUoGCpeRY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N5Q5 uniprotkb:P58340 intact:EBI-9380321 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q8n5q5_human(display_long) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380324|imex:IM-22301-1109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8N5Q5(identity)|entrezgene/locuslink:4204(identity)|ddbj/embl/genbank:BC011612(identity)|human orfeome collection:6191(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lCzLJ7/RKAbwI5Nj3sJNgHUWE2s9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:6AC8B07433E3CEB3|rigid:W9edAm+RWkviVUmbylmi0ix58Kg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q8N5Q5 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9380321 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q8n5q5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380346|imex:IM-22301-1110 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) uniprotkb:Q8N5Q5(identity)|entrezgene/locuslink:4204(identity)|ddbj/embl/genbank:BC011612(identity)|human orfeome collection:6191(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:lCzLJ7/RKAbwI5Nj3sJNgHUWE2s9606 intact-crc:8C381FEDAB45A361|rigid:DMTdr2IZ/9i2y0BXdZQO1dFwXLQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N5Q5 uniprotkb:Q96BE0 intact:EBI-9380321 intact:EBI-9356686 psi-mi:q8n5q5_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380367|imex:IM-22301-1111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8N5Q5(identity)|entrezgene/locuslink:4204(identity)|ddbj/embl/genbank:BC011612(identity)|human orfeome collection:6191(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lCzLJ7/RKAbwI5Nj3sJNgHUWE2s9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:D028776C6B7099A1|rigid:9SLDiOUVlc6ge+QUMjAdBLiZNBE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q8N6T7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380389|imex:IM-22301-1112 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 intact-crc:DD7BA3E6F241AB5F|rigid:T2+zjFpLorp33Er/THycS8x67FA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q8N6T7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380411|imex:IM-22301-1113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 intact-crc:24B4D24B175A6588|rigid:rN2pCgaks74lr2r+/Fac/aCaVrw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6T7 uniprotkb:Q96BE0 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 intact:EBI-9356686 psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380474|imex:IM-22301-1116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:CF47278E361760CE|rigid:x1xCpU/9PDjsB46VqQukoYOIaL0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6T7 uniprotkb:Q03933 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380433|imex:IM-22301-1114 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:F5224F7AA6B07B39|rigid:EtM7giBarOo+W844nyPTiaSadrA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6T7 uniprotkb:Q13200 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380452|imex:IM-22301-1115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:1948D41084F70F2E|rigid:BzwXsnBAdao1DidjuSMPkvJh+NI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q8N6T7 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380496|imex:IM-22301-1117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 intact-crc:9131D8280D693FB7|rigid:iHe45lHaFcbvs4vrbE2y64MIt4o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q8N6T7 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380515|imex:IM-22301-1118 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 intact-crc:B91A39E6E1F9BE9D|rigid:JNuvTaj7DUuurvIbeQt4nXPJNos false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6T7 uniprotkb:Q9BTE6-2 intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380537|imex:IM-22301-1119 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N|uniprotkb:Q8N6T7(identity)|entrezgene/locuslink:51548(identity)|human orfeome collection:5010(identity)|ddbj/embl/genbank:BC005026(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:2D39725BA489BE4B|rigid:06qvvmtSQgQJRWZWlzbO2MHuYQU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7L3B6 uniprotkb:Q8N799 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-9380559|ensembl:ENSP00000302917 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:q8n799_human(display_long)|uniprotkb:SPATA24(gene name)|psi-mi:SPATA24(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380563|imex:IM-22301-1120 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|human orfeome collection:7338(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000170469(gene)|ensembl:ENST00000302091(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR029176|uniprotkb:Q8N799(identity)|human orfeome collection:11642(identity)|ddbj/embl/genbank:BC050563(identity)|entrezgene/locuslink:202051(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:LuCKNoH9DWUi0e2NB8duK6Bp3ww9606 intact-crc:7F1554A095BF8EC4|rigid:KNZNDFbce7TlGLI2W9jHrKqrE6E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N812 uniprotkb:Q13451 intact:EBI-9380588 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:cl076_human(display_long)|uniprotkb:C12orf76(gene name)|psi-mi:C12orf76(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380585|imex:IM-22301-1121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041240|refseq:NP_997318.1|uniprotkb:Q8N812(identity)|entrezgene/locuslink:400073(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Abl0q2+F8g6dWpLkrcfD5ltgBao9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:FE143DBD66DBCFC7|rigid:X38XfiNB4jLpwD71JzDTcV7DE4c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q8N812 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9380588 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cl076_human(display_long)|uniprotkb:C12orf76(gene name)|psi-mi:C12orf76(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380606|imex:IM-22301-1122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) interpro:IPR041240|refseq:NP_997318.1|uniprotkb:Q8N812(identity)|entrezgene/locuslink:400073(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Abl0q2+F8g6dWpLkrcfD5ltgBao9606 intact-crc:4A0FFEBA7D032D0B|rigid:w2K0nCO07/SESvW546d3wBcvoK4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N8C6 uniprotkb:Q9BTE6-2 intact:EBI-9380627 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q8n8c6_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380624|imex:IM-22301-1123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR038807|uniprotkb:Q8N8C6(identity)|entrezgene/locuslink:284992(identity)|human orfeome collection:13371(identity)|ddbj/embl/genbank:BC062449(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QRt4axK4FI29j/8yWvKge+07ozE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:D4842C0EBC8AF25D|rigid:9vwsh8iGOcPuBiQarUVWEReItpY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N9S9 uniprotkb:Q8WVJ2 intact:EBI-9380649|uniprotkb:C9J6L9|uniprotkb:Q8N0U9|ensembl:ENSP00000312368 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:snx31_human(display_long)|uniprotkb:SNX31(gene name)|psi-mi:SNX31(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380655|imex:IM-22301-1124 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689841.3|refseq:XP_005250872.1|ensembl:ENSG00000174226(gene)|ensembl:ENST00000311812(transcript)|go:"GO:0005769"(early endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|interpro:IPR001683(Phox-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036871|interpro:IPR037831|interpro:IPR040842|uniprotkb:Q8N9S9(identity)|ddbj/embl/genbank:BC031260(identity)|entrezgene/locuslink:169166(identity)|human orfeome collection:2216(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZXyiNj6BDk8mriVw313bhY08Yv49606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:82E10BB0C8003F90|rigid:QWq37bE/fy99C+F6OkSraqxzfsM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q8NHX6 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9380674 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q8nhx6_human(display_long)|uniprotkb:HCC5(gene name)|psi-mi:HCC5(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380678|imex:IM-22301-1125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR031327|interpro:IPR033762|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR041562|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0042555"(MCM complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|uniprotkb:Q8NHX6(identity)|ddbj/embl/genbank:BC001626(identity)|entrezgene/locuslink:4172(identity)|human orfeome collection:3726(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:S33qHFWKzNKHMwls7Sl+wwFVPAY9606 intact-crc:2A4A696D54724C62|rigid:Wffw1dzyZa3szvq+Hp/J9xY8iZ4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q8NHY5 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380700|imex:IM-22301-1126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 intact-crc:6EA2F31B44D022DB|rigid:UavQVO/JA1RPuLALZz0LyzbMhz8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NHY5 uniprotkb:Q15773 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380727|imex:IM-22301-1127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:9AB799A59ECCCF28|rigid:cSEhRvGP4/FKEVqZWq+3PM5Z5/k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NHY5 uniprotkb:Q03933 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380749|imex:IM-22301-1128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:94BB54E5FB3EF434|rigid:V9QwDyGNXuXZdkxzHlR6Gu+Xzn8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q8NHY5 intact:EBI-9357141 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 psi-mi:q9hav2_human(display_long) psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380768|imex:IM-22301-1129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 intact-crc:F96483354E35F588|rigid:UA3ZC2DY6j8Fnul1lhGT8yyr4HM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NHY5 uniprotkb:Q13200 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380790|imex:IM-22301-1130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:3E38A01ECBBEA470|rigid:jTcDekfcBb8WAtSb5KtEO9hJp7g false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q8NHY5 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380812|imex:IM-22301-1131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 intact-crc:1D0AE3816928BAD1|rigid:FBS56pry+v2a0wmOB912doTonF8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NHY5 uniprotkb:Q9UNE7 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380831|imex:IM-22301-1132 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:05EF1B29A5E68D73|rigid:kcxII/QgEF18Hv9dw2E9xmKXeYk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q8NHY5 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9380703|uniprotkb:Q5T4Z2|ensembl:ENSP00000370293 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:hus1b_human(display_long)|uniprotkb:HUS1B(gene name)|psi-mi:HUS1B(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380853|imex:IM-22301-1133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_683762.2|ensembl:ENSG00000188996(gene)|ensembl:ENST00000380907(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005730"(nucleolus)|interpro:IPR016580(Cell cycle checkpoint, HUS1)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0030896"(checkpoint clamp complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044778"(meiotic DNA integrity checkpoint signaling)|interpro:IPR007150(Hus1-like protein)|uniprotkb:Q8NHY5(identity)|ddbj/embl/genbank:BC101699(identity)|human orfeome collection:71809(identity)|entrezgene/locuslink:135458(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:0ZU9T4g7XISOfCMNaG11SdHXJfQ9606 intact-crc:341248C5ABEA13C8|rigid:WKo+bqawBibrcwvyk0U21b+YS00 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q13451 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380875|imex:IM-22301-1134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:C97CF65CBFF6A463|rigid:45cBXATCQsAH2w2JMM3nvTVqDw8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q8NI51 intact:EBI-9356629 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380894|imex:IM-22301-1135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 intact-crc:30324212C5389B50|rigid:bOWxxH80cGQLjt57LqfC2GPxLZM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8NI51 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380960|imex:IM-22301-1138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 intact-crc:4E4359925B4A61CA|rigid:AOLBK3G3yGtX3rf1k/zRVGtmJeg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q53FC7 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-9356749 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380916|imex:IM-22301-1136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:19A58B6F94DDF292|rigid:gFRhohOC89KUQl2oUOCzNfVAkD0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q8IWX7 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380938|imex:IM-22301-1137 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|human orfeome collection:52773(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 intact-crc:4B5BEFAF23088BAD|rigid:qNpUWUBPtbdxUvRKBASH7iZ5XkA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q9HAV2 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-9357141 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9380979|imex:IM-22301-1139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:23E8C761001F279A|rigid:pN0pw3vcHXPnWJ927esDRSOqvzs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q8NI51 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381001|imex:IM-22301-1140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 intact-crc:91E306C99D511AE2|rigid:043NZbXboBOMPW+TgiNe7o0NR5E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:B4DYC6 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-9357028 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381020|imex:IM-22301-1141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:1C0F79EF0BA629A2|rigid:iDRpJj8irZUwd+brTHSNEB5ZJLo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:O43765 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381040|imex:IM-22301-1142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:A64B2696FCE40B95|rigid:ZBM7C79sdw0AlWTOhr2AscAqrb0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q96BE0 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-9356686 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381062|imex:IM-22301-1143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:F047267A0CBE05FF|rigid:MG4Q2qiysvn9K7bSHF/+7Q0ynWQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q8NI51 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381084|imex:IM-22301-1144 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 intact-crc:BECBE951B8A5FA80|rigid:qVtCdKgMN2SmtUkWaxpU6ijh2yQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q9UNE7 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381103|imex:IM-22301-1145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:5BBFD10266158344|rigid:3ZIFTXL6B6G4nZcASzsKqnozPx0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NI51 uniprotkb:Q8WVJ2 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381125|imex:IM-22301-1146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:6088C12B40CE47F3|rigid:mhCfgnlKNarqZEytpP4pvowFL0E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q8NI51 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9089302|uniprotkb:A6XGL8|uniprotkb:A6XGN3|uniprotkb:A6XGM3|uniprotkb:A6XGM2|uniprotkb:E7EQ27|uniprotkb:Q5JUG4|uniprotkb:Q9BZ30|uniprotkb:A1L4C6|uniprotkb:E9PBA9|uniprotkb:E7EUE3|uniprotkb:A6XGN1|uniprotkb:A0S6W1|uniprotkb:A6XGM8|uniprotkb:Q9NQJ3|uniprotkb:A6XGN0|uniprotkb:A6XGN2|uniprotkb:A6XGN4|ensembl:ENSP00000243914|ensembl:ENSP00000360239|ensembl:ENSP00000476398|ensembl:ENSP00000476783 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:ctcfl_human(display_long)|uniprotkb:BORIS(gene name synonym)|uniprotkb:Brother of the regulator of imprinted sites(gene name synonym)|uniprotkb:CCCTC-binding factor(gene name synonym)|uniprotkb:CTCF paralog(gene name synonym)|uniprotkb:CTCF-like protein(gene name synonym)|uniprotkb:Cancer/testis antigen 27(gene name synonym)|uniprotkb:Zinc finger protein CTCF-T(gene name synonym)|uniprotkb:CTCFL(gene name)|psi-mi:CTCFL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381144|imex:IM-22301-1147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001255979.1|refseq:NP_001255969.1|refseq:NP_001255970.1|refseq:NP_001255971.1|refseq:NP_001255972.1|refseq:NP_001255973.1|refseq:NP_001255974.1|refseq:NP_001255975.1|refseq:NP_001255976.1|refseq:NP_001255977.1|refseq:NP_001255978.1|refseq:NP_001255983.1|refseq:NP_542185.2|refseq:NP_001255980.1|refseq:NP_001255981.1|refseq:NP_001255984.1|ensembl:ENSG00000124092(gene)|ensembl:ENST00000243914(transcript)|ensembl:ENST00000371196(transcript)|ensembl:ENST00000608263(transcript)|ensembl:ENST00000609232(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016571"(histone methylation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0043035"(chromatin insulator sequence binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|uniprotkb:Q8NI51(identity)|entrezgene/locuslink:140690(identity)|human orfeome collection:54781(identity)|ddbj/embl/genbank:BC130486(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:Zd3flpao63rSVBYKkR13uDujwwA9606 intact-crc:D6260A2B87D1631A|rigid:su68ReMOzSnow0zPhzbPzOCYu2k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:O95801 intact:EBI-9381166 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 psi-mi:q8ta90_human(display_long) psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381169|imex:IM-22301-1148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 intact-crc:80E2D702660199A3|rigid:WxSEsswspRziTdACVZQNVOWdi98 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q8TA90 intact:EBI-9356749 intact:EBI-9381166 psi-mi:q53fc7_human(display_long) psi-mi:q8ta90_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381188|imex:IM-22301-1149 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 intact-crc:30C35FEEE27FEDC6|rigid:RUIjDlAByJmqFzLc9ebDMGigV60 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:Q8IVD9 intact:EBI-9381166 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q8ta90_human(display_long) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381210|imex:IM-22301-1150 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:0DCC2F481799A9C0|rigid:yOxfSAoSGjbnjdBVkE8RWQmjF6Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:Q96BE0 intact:EBI-9381166 intact:EBI-9356686 psi-mi:q8ta90_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381229|imex:IM-22301-1151 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:A460E89D09E9FC41|rigid:mA7QwSVtUBfYQKqX4pd399BvWHY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:P31948 intact:EBI-9381166 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q8ta90_human(display_long) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381251|imex:IM-22301-1152 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:E5CCDF6657860F6F|rigid:jGuDTnbbj2+y1dUxaYkl6Sp8XQA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:Q9BTE6-2 intact:EBI-9381166 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q8ta90_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381270|imex:IM-22301-1153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:D0DF1DA12FFEB61E|rigid:FsnatPLo4nim5R+x2oJxOa7ol4k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TA90 uniprotkb:Q9BPW0 intact:EBI-9381166 intact:EBI-9356778 psi-mi:q8ta90_human(display_long) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381292|imex:IM-22301-1154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR035647|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR041095|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005525"(GTP binding)|uniprotkb:Q8TA90(identity)|ddbj/embl/genbank:BC126259(identity)|entrezgene/locuslink:1938(identity)|human orfeome collection:54407(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5IwAkEouyeRsly21GizRPlKcXS09606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:7CCA44FA2DA5924D|rigid:ESHS7SwQiZ/2+o+twN5SVsMkdiA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q8TBI1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9381314 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q8tbi1_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381318|imex:IM-22301-1155 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|uniprotkb:Q8TBI1(identity)|human orfeome collection:1279(identity)|entrezgene/locuslink:4129(identity)|ddbj/embl/genbank:BC022494(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:ODjhrigPpDegnRnhvUQdTN5dLyk9606 intact-crc:696D8D0832A0D6B8|rigid:Fphi0TxP9fOhPeswv7v2ynN+pb4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TBI1 uniprotkb:Q96BE0 intact:EBI-9381314 intact:EBI-9356686 psi-mi:q8tbi1_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381339|imex:IM-22301-1156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|uniprotkb:Q8TBI1(identity)|human orfeome collection:1279(identity)|entrezgene/locuslink:4129(identity)|ddbj/embl/genbank:BC022494(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ODjhrigPpDegnRnhvUQdTN5dLyk9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:EA365DDBE843B207|rigid:/FTVKw8WWdcPY3a8n2gtkp+8Bts false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TBI1 uniprotkb:Q9HB71 intact:EBI-9381314 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q8tbi1_human(display_long)|uniprotkb:MAOB(gene name)|psi-mi:MAOB(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381361|imex:IM-22301-1157 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001613(Flavin-containing amine oxidase)|interpro:IPR002937(Amine oxidase)|interpro:IPR036188|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|uniprotkb:Q8TBI1(identity)|human orfeome collection:1279(identity)|entrezgene/locuslink:4129(identity)|ddbj/embl/genbank:BC022494(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ODjhrigPpDegnRnhvUQdTN5dLyk9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:CB849A2C4AFA30EA|rigid:2POZWC58zI1zhzz7zIvl7KrK0jM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TC59 uniprotkb:Q13451 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381392|imex:IM-22301-1158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:980D025A993F1748|rigid:58IhbQNT8VT6txBrkU6VgfsdbLM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q8TC59 intact:EBI-9356629 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381411|imex:IM-22301-1159 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 intact-crc:1913166973BD1B10|rigid:rU4kxKT1OUtLJU+emKuEVcvOlo8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TC59 uniprotkb:B4DYC6 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 intact:EBI-9357028 psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381433|imex:IM-22301-1160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:4F93EBE76513E9F6|rigid:4aIa83gFkjCz2ortPelCLOykpAg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q8TC59 intact:EBI-9356686 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 psi-mi:q96be0_human(display_long) psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381453|imex:IM-22301-1161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 intact-crc:11E2301A570E0FF4|rigid:HHUBSisCdR8EmsS0bigCHqj6fq4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TC59 uniprotkb:P07900 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381475|imex:IM-22301-1162 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:AB4FE319F1A7DE53|rigid:Sm1sEXKuIyX9/sjmGd+F/D/F3OY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TC59 uniprotkb:P31948 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381496|imex:IM-22301-1163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:D6E9C1FB7CBC4597|rigid:l2bTyJb4h593VLGyhwYJ2Gg83bM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TC59 uniprotkb:Q9BTE6-2 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381535|imex:IM-22301-1165 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:C56DFEBACF1AF8B3|rigid:/TMY8dK3IR22nRM1zu3R7Gg7VsA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15185 uniprotkb:Q8TC59 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381515|imex:IM-22301-1164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 intact-crc:2819E675433AB947|rigid:K/nP2u2ihpwrWKt3PmdlP6/dqgo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TCJ0 uniprotkb:Q13451 intact:EBI-1161114|uniprotkb:Q6PJ83|uniprotkb:Q7Z4V4|uniprotkb:Q9UKB8|ensembl:ENSP00000372274 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:fbx25_human(display_long)|uniprotkb:FBXO25(gene name)|psi-mi:FBXO25(display_short)|uniprotkb:FBX25(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381579|imex:IM-22301-1167 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036305.2|refseq:NP_904356.1|refseq:NP_904357.1|refseq:XP_011533050.1|ensembl:ENSG00000147364(gene)|ensembl:ENST00000382824(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|interpro:IPR036047|interpro:IPR040394|refseq:XP_016868802.1|uniprotkb:Q8TCJ0(identity)|ddbj/embl/genbank:BC020249(identity)|human orfeome collection:13505(identity)|entrezgene/locuslink:26260(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DCtlJ0IzLax4qCOgwpFu/hcAZHE9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:6EC1EA51716FAAAF|rigid:tBaJ5Nq6XO8SKuLcuOmj3jD0eI4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q8TC59 intact:EBI-9356778 intact:EBI-9381380|uniprotkb:B0AZN9|uniprotkb:A8K8S5|uniprotkb:E7ECA4|uniprotkb:A8K4S3|uniprotkb:B4DR22|uniprotkb:B0AZP2|uniprotkb:Q96SW6|uniprotkb:Q9NW28|ensembl:ENSP00000349208|ensembl:ENSP00000406956 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:piwl2_human(display_long)|uniprotkb:PIWIL2(gene name)|psi-mi:PIWIL2(display_short)|uniprotkb:Cancer/testis antigen 80(gene name synonym)|uniprotkb:HILI(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381557|imex:IM-22301-1166 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_001317409.1|refseq:NP_001129193.1|refseq:NP_060538.2|ensembl:ENSG00000197181(gene)|ensembl:ENST00000356766(transcript)|ensembl:ENST00000454009(transcript)|go:"GO:0000966"(RNA 5'-end processing)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010370"(perinucleolar chromocenter)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043186"(P granule)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048477"(oogenesis)|go:"GO:0048511"(rhythmic process)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060903"(positive regulation of meiosis I)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071546"(pi-body)|go:"GO:0097433"(dense body)|go:"GO:1905538"(polysome binding)|go:"GO:1990511"(piRNA biosynthetic process)|go:"GO:1990923"(PET complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR036085|interpro:IPR036397|rcsb pdb:3O7X|rcsb pdb:3QIR|reactome:R-HSA-5601884|uniprotkb:Q8TC59(identity)|entrezgene/locuslink:55124(identity)|ddbj/embl/genbank:BC025995(identity)|human orfeome collection:1491(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:ncuBL7IWBxmvsIhMIfrs5laJ1bg9606 intact-crc:F98416F8FF2A0AAB|rigid:YKj7O9qah/GGgoUUKDOVz0s1SFQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TCJ0 uniprotkb:B4DYC6 intact:EBI-1161114|uniprotkb:Q6PJ83|uniprotkb:Q7Z4V4|uniprotkb:Q9UKB8|ensembl:ENSP00000372274 intact:EBI-9357028 psi-mi:fbx25_human(display_long)|uniprotkb:FBXO25(gene name)|psi-mi:FBXO25(display_short)|uniprotkb:FBX25(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381620|imex:IM-22301-1169 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036305.2|refseq:NP_904356.1|refseq:NP_904357.1|refseq:XP_011533050.1|ensembl:ENSG00000147364(gene)|ensembl:ENST00000382824(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|interpro:IPR036047|interpro:IPR040394|refseq:XP_016868802.1|uniprotkb:Q8TCJ0(identity)|ddbj/embl/genbank:BC020249(identity)|human orfeome collection:13505(identity)|entrezgene/locuslink:26260(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:DCtlJ0IzLax4qCOgwpFu/hcAZHE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:A942EED1856DBAF1|rigid:4mAaBxNEYtsbub+nyYsQcSkGA9o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TCJ0 uniprotkb:Q6PK50 intact:EBI-1161114|uniprotkb:Q6PJ83|uniprotkb:Q7Z4V4|uniprotkb:Q9UKB8|ensembl:ENSP00000372274 intact:EBI-9356629 psi-mi:fbx25_human(display_long)|uniprotkb:FBXO25(gene name)|psi-mi:FBXO25(display_short)|uniprotkb:FBX25(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381598|imex:IM-22301-1168 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036305.2|refseq:NP_904356.1|refseq:NP_904357.1|refseq:XP_011533050.1|ensembl:ENSG00000147364(gene)|ensembl:ENST00000382824(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|interpro:IPR036047|interpro:IPR040394|refseq:XP_016868802.1|uniprotkb:Q8TCJ0(identity)|ddbj/embl/genbank:BC020249(identity)|human orfeome collection:13505(identity)|entrezgene/locuslink:26260(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DCtlJ0IzLax4qCOgwpFu/hcAZHE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:4B212490C8DE9242|rigid:R4lpHcUaj/Yq1PVGHkMYOBC9Www false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q8TCJ0 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-1161114|uniprotkb:Q6PJ83|uniprotkb:Q7Z4V4|uniprotkb:Q9UKB8|ensembl:ENSP00000372274 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:fbx25_human(display_long)|uniprotkb:FBXO25(gene name)|psi-mi:FBXO25(display_short)|uniprotkb:FBX25(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381640|imex:IM-22301-1170 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_036305.2|refseq:NP_904356.1|refseq:NP_904357.1|refseq:XP_011533050.1|ensembl:ENSG00000147364(gene)|ensembl:ENST00000382824(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|interpro:IPR036047|interpro:IPR040394|refseq:XP_016868802.1|uniprotkb:Q8TCJ0(identity)|ddbj/embl/genbank:BC020249(identity)|human orfeome collection:13505(identity)|entrezgene/locuslink:26260(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:DCtlJ0IzLax4qCOgwpFu/hcAZHE9606 intact-crc:6ABF18444F2EA658|rigid:XRCdbLwZdOoF2RPw89LkaE9VsFs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q8TDZ3 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9381686 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q8tdz3_human(display_long)|uniprotkb:MYHbeta(gene name)|psi-mi:MYHbeta(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381683|imex:IM-22301-1172 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) uniprotkb:Q8TDZ3(identity)|ddbj/embl/genbank:BC003178(identity)|entrezgene/locuslink:4595(identity)|human orfeome collection:3901(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:YOFdOY8jLooeutXipB9TSNOa0ss9606 intact-crc:5D58054C70FE9A6D|rigid:3Zrh1RpmMQxIq3TX9pyoVY40y0Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TCJ0 uniprotkb:Q9BPW0 intact:EBI-1161114|uniprotkb:Q6PJ83|uniprotkb:Q7Z4V4|uniprotkb:Q9UKB8|ensembl:ENSP00000372274 intact:EBI-9356778 psi-mi:fbx25_human(display_long)|uniprotkb:FBXO25(gene name)|psi-mi:FBXO25(display_short)|uniprotkb:FBX25(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381661|imex:IM-22301-1171 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036305.2|refseq:NP_904356.1|refseq:NP_904357.1|refseq:XP_011533050.1|ensembl:ENSG00000147364(gene)|ensembl:ENST00000382824(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|interpro:IPR036047|interpro:IPR040394|refseq:XP_016868802.1|uniprotkb:Q8TCJ0(identity)|ddbj/embl/genbank:BC020249(identity)|human orfeome collection:13505(identity)|entrezgene/locuslink:26260(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:DCtlJ0IzLax4qCOgwpFu/hcAZHE9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:8AA0881833027BEE|rigid:HuUUfkB8r5CRbXf0OmoERUliR88 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TDZ3 uniprotkb:Q15773 intact:EBI-9381686 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q8tdz3_human(display_long)|uniprotkb:MYHbeta(gene name)|psi-mi:MYHbeta(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381709|imex:IM-22301-1173 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8TDZ3(identity)|ddbj/embl/genbank:BC003178(identity)|entrezgene/locuslink:4595(identity)|human orfeome collection:3901(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:YOFdOY8jLooeutXipB9TSNOa0ss9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:9A44D9840F5BAD7D|rigid:15itNRWBNymoE8PkYdQ4XU/D2Qs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q8TDZ3 intact:EBI-9356686 intact:EBI-9381686 psi-mi:q96be0_human(display_long) psi-mi:q8tdz3_human(display_long)|uniprotkb:MYHbeta(gene name)|psi-mi:MYHbeta(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381731|imex:IM-22301-1174 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) uniprotkb:Q8TDZ3(identity)|ddbj/embl/genbank:BC003178(identity)|entrezgene/locuslink:4595(identity)|human orfeome collection:3901(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:YOFdOY8jLooeutXipB9TSNOa0ss9606 intact-crc:8C8BFDA0A5BC5986|rigid:Ox5aoqnllD6jgFKxZ8c4tNre7ZI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TDZ3 uniprotkb:Q9BTE6-2 intact:EBI-9381686 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q8tdz3_human(display_long)|uniprotkb:MYHbeta(gene name)|psi-mi:MYHbeta(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381772|imex:IM-22301-1176 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8TDZ3(identity)|ddbj/embl/genbank:BC003178(identity)|entrezgene/locuslink:4595(identity)|human orfeome collection:3901(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YOFdOY8jLooeutXipB9TSNOa0ss9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:5376CB5194899210|rigid:tZFG8n2UEvUjsMBrd7LQpg2p+Jc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TDZ3 uniprotkb:P31948 intact:EBI-9381686 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q8tdz3_human(display_long)|uniprotkb:MYHbeta(gene name)|psi-mi:MYHbeta(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381753|imex:IM-22301-1175 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8TDZ3(identity)|ddbj/embl/genbank:BC003178(identity)|entrezgene/locuslink:4595(identity)|human orfeome collection:3901(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YOFdOY8jLooeutXipB9TSNOa0ss9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:7F3E053685FFDBE7|rigid:y/2jV1yGOQWJJOuFlBwdx5fQoyc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TEN0 uniprotkb:Q13451 intact:EBI-9381794 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q8ten0_human(display_long)|uniprotkb:FLJ00163(gene name)|psi-mi:FLJ00163(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381798|imex:IM-22301-1177 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR030083|interpro:IPR037445|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042981"(regulation of apoptotic process)|uniprotkb:Q8TEN0(identity)|ddbj/embl/genbank:BC032473(identity)|human orfeome collection:9625(identity)|entrezgene/locuslink:9500(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WerxF2ex6idktT3VGcBg8NfARpw9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:4593758658F33557|rigid:D40vzu1fct1oppv7HGjrhc4zP1E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q8WVL7 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9381820|uniprotkb:Q9NXK7|uniprotkb:Q8NDF2|uniprotkb:Q96JE5|ensembl:ENSP00000303518|ensembl:ENSP00000440396 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:anr49_human(display_long)|uniprotkb:ANKRD49(gene name)|psi-mi:ANKRD49(display_short)|uniprotkb:FGIF(gene name synonym)|uniprotkb:Fetal globin-inducing factor(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381817|imex:IM-22301-1178 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:XP_016873430.1|refseq:NP_060174.2|dip:DIP-61280N|ensembl:ENSG00000168876(gene)|ensembl:ENST00000302755(transcript)|ensembl:ENST00000544612(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|uniprotkb:Q8WVL7(identity)|human orfeome collection:12950(identity)|entrezgene/locuslink:54851(identity)|ddbj/embl/genbank:BC017798(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:CqaXSfdo5/Rgwa/Zm6bKu5CAv8g9606 intact-crc:2ED163C6DFBC647D|rigid:OzcRljsqercQDc8Eygm+YjoRvbI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WW22 uniprotkb:Q8WW22 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381843|imex:IM-22301-1179 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 intact-crc:9F34C2689B013959|rigid:cykzfVoFCDjmzxrCwHHutNB4KGg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WW22 uniprotkb:Q9BTE6-2 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381865|imex:IM-22301-1180 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|human orfeome collection:1895(identity)|entrezgene/locuslink:55466(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:A70047E7EC982BA5|rigid:Cv1u02iQhNh2oVm9Rj878aYY5BU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q8WYX9 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9381913 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381917|imex:IM-22301-1182 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 intact-crc:0D18176B515C7B28|rigid:FgviSLZognR9oBKotvcwd/TZwqo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q8WXU2-2 intact:EBI-9356778 intact:EBI-9381887|ensembl:ENSP00000403412 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:q8wxu2-2(display_long)|uniprotkb:DNAAF4(gene name)|psi-mi:DNAAF4(display_short)|uniprotkb:DYX1C1(gene name synonym)|uniprotkb:Dyslexia susceptibility 1 candidate gene 1 protein(gene name synonym)|uniprotkb:EKN1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381891|imex:IM-22301-1181 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) ensembl:ENSG00000256061(gene)|ensembl:ENST00000448430(transcript)|uniprotkb:Q8WXU2-2(isoform-parent)|intact:EBI-2946907(isoform-parent)|uniprotkb:Q8WXU2-2(identity)|human orfeome collection:12114(identity)|ddbj/embl/genbank:BC062564(identity)|entrezgene/locuslink:161582(identity) psi-mi:"MI:0469"(intact) - isoform-comment:No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:jYtZBqy6D77KSvFPNp8nBddDD1s9606 intact-crc:7DFDAD290E89ECEE|rigid:BahYAfikc21vln4UPG/4nMNxwYk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:Q53FC7 intact:EBI-9381913 intact:EBI-9356749 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381938|imex:IM-22301-1183 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:EE7628DFB12DF437|rigid:1DIJpJEy7WI6uCaMxP58b8L1DeA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:O95816 intact:EBI-9381913 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381960|imex:IM-22301-1184 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:07072DAB9C6A913A|rigid:bgHqNofMI/rJSoU9cSqvm5rW5cw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:Q8IVD9 intact:EBI-9381913 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9381982|imex:IM-22301-1185 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:9219B9823CE63ED2|rigid:CQ8qDXTeS/WgatiA/KXecB0MPLU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q8WYX9 intact:EBI-9356686 intact:EBI-9381913 psi-mi:q96be0_human(display_long) psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382001|imex:IM-22301-1186 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 intact-crc:3518FF80810F3717|rigid:ISnOKceC8DR5JJyEktmgb9eZqmU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:Q9UNE7 intact:EBI-9381913 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382023|imex:IM-22301-1187 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:05F596AA3195356C|rigid:75T4IaFk9VUWBOPiD1tWrw9QaWw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:Q9HB71 intact:EBI-9381913 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382045|imex:IM-22301-1188 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:A1A3EF8EF01647B8|rigid:s/Q1P0oBSpBFZwTJm9H2U4MVjMg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:Q9BTE6-2 intact:EBI-9381913 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382085|imex:IM-22301-1190 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:28AC95AEFE922945|rigid:r+NhCpqgvWGLUm1RjdH80T08WrY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-2 uniprotkb:Q8WYX9 intact:EBI-9359023|ensembl:ENSMUSP00000082119 intact:EBI-9381913 psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382064|imex:IM-22301-1189 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 intact-crc:914EEA44C89049CB|rigid:YlG9cJxPRluVBnKw1Fokx60FYgk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q92598 intact:EBI-9356686 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:q96be0_human(display_long) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382129|imex:IM-22301-1192 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453|uniprotkb:Q92598(identity)|ddbj/embl/genbank:BC037553(identity)|entrezgene/locuslink:10808(identity)|human orfeome collection:9615(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:BDE33C7BE33D6C15|rigid:3rm3R2tzgwSpooRk1Va3c0y/eWA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WYX9 uniprotkb:B3KTT5 intact:EBI-9381913 intact:EBI-8783896 psi-mi:q8wyx9_human(display_long)|uniprotkb:pp10122(gene name)|psi-mi:pp10122(display_short) psi-mi:b3ktt5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382107|imex:IM-22301-1191 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001619(Sec1-like protein)|interpro:IPR036045|interpro:IPR043154|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|uniprotkb:Q8WYX9(identity)|entrezgene/locuslink:6813(identity)|ddbj/embl/genbank:BC002869(identity)|human orfeome collection:4409(identity) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:YvztI3qkkAak7cRfJbFirs8aH3M9606 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 intact-crc:2AA8F3B6E68C39FD|rigid:vGc6+DQoltiIvOl1r0LbR9PmQys false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RS6 uniprotkb:Q92620 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1043041|uniprotkb:O75212|uniprotkb:Q96HN7|ensembl:ENSP00000268482|uniprotkb:D3DWS7|uniprotkb:B4DVG8 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:prp16_human(display_long)|uniprotkb:DHX38(gene name)|psi-mi:DHX38(display_short)|uniprotkb:DDX38(gene name synonym)|uniprotkb:KIAA0224(gene name synonym)|uniprotkb:PRP16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DHX38(gene name synonym)|uniprotkb:DEAH box protein 38(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382151|imex:IM-22301-1193 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000140829(gene)|ensembl:ENST00000268482(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016020"(membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q92620|rcsb pdb:5YZG|rcsb pdb:6ZYM|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_054722.2|refseq:XP_011521786.1|refseq:XP_011521787.1|uniprotkb:Q92620(identity)|ddbj/embl/genbank:BC004235(identity)|entrezgene/locuslink:9785(identity)|human orfeome collection:3493(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:miHZNGhDUIz9imwhlPz2tIsCNLs9606 intact-crc:84C97CD7C5ED23B6|rigid:VaRIbJ0PLuJ/64OvxAmwosFp7ws false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92925 uniprotkb:Q13451 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382170|imex:IM-22301-1194 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:C1FF4DC548E7A9A9|rigid:niha0lJo2T88jAMvGOiNHLunvFc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q92925 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382189|imex:IM-22301-1195 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:0C7F068D686D941A|rigid:Ld6atY+QPXrYINeUh0ToHG/6dC8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q92925 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382211|imex:IM-22301-1196 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:788832B221157C18|rigid:UG+MODAPVzJHi7/KplOKC/+j9Gk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92925 uniprotkb:O95816 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382233|imex:IM-22301-1197 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:C101E170C47E28D2|rigid:o+M4bN7G7dIgKhofF2EAoR65h2s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92925 uniprotkb:Q13200 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382255|imex:IM-22301-1198 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:7921798E703B32B9|rigid:msRVPO34Qn38FcKp5pBybeCnlb0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q92925 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382299|imex:IM-22301-1200 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:B2A058B9EFB78595|rigid:GqAi3n83QW5w0OcetGmwKyfkWTI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q92925 intact:EBI-9356686 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:q96be0_human(display_long) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382277|imex:IM-22301-1199 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:A52AE0E097BF4ED4|rigid:06AOYLyToZmhaOmqptMRmEMR+Yg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q92925 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382321|imex:IM-22301-1201 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:77375A0397BA5DA5|rigid:4/O+m9PEnIUfqYsPUygaaaxnHLQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q92925 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-358441|uniprotkb:Q7L2I6|uniprotkb:Q9UHZ1|uniprotkb:A5PLL5|uniprotkb:A6NNQ7|uniprotkb:B4DV56|uniprotkb:B4E1R6|ensembl:ENSP00000392617 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:smrd2_human(display_long)|uniprotkb:PRO2451(orf name)|uniprotkb:SMARCD2(gene name)|psi-mi:SMARCD2(display_short)|uniprotkb:BAF60B(gene name synonym)|uniprotkb:60 kDa BRG-1/Brm-associated factor subunit B(gene name synonym)|uniprotkb:BRG1-associated factor 60B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382340|imex:IM-22301-1202 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001091896.1|dip:DIP-31182N|refseq:NP_001317369.1|ensembl:ENSG00000108604(gene)|ensembl:ENST00000448276(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043044"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR019835|interpro:IPR030090|interpro:IPR036885|mint:Q92925|reactome:R-HSA-3214858|reactome:R-HSA-8939243|uniprotkb:Q92925(identity)|ddbj/embl/genbank:BC142963(identity)|entrezgene/locuslink:6603(identity)|human orfeome collection:72189(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:n6YHBJ+cqEmVcXwMYsTZGOfL86A9606 intact-crc:CAABAEEC2BAF05AC|rigid:H1/F2EAmPwxnspYeNszgJFHeah0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92993 uniprotkb:Q15773 intact:EBI-399080|uniprotkb:O95624|uniprotkb:Q13430|uniprotkb:Q17RW5|uniprotkb:Q6GSE8|uniprotkb:Q9BWK7|uniprotkb:Q561W3|intact:EBI-28987721|ensembl:ENSP00000366245|uniprotkb:C9JL99|uniprotkb:B4E3C7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:kat5_human(display_long)|uniprotkb:KAT5(gene name)|psi-mi:KAT5(display_short)|uniprotkb:TIP60(gene name synonym)|uniprotkb:HTATIP(gene name synonym)|uniprotkb:Lysine acetyltransferase 5(gene name synonym)|uniprotkb:"cPLA(2)-interacting protein"(gene name synonym)|uniprotkb:Histone acetyltransferase HTATIP(gene name synonym)|uniprotkb:60 kDa Tat-interactive protein(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382362|imex:IM-22301-1203 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006379.2|refseq:NP_874368.1|refseq:NP_874369.1|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-9018519|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037995|interpro:IPR040706|rcsb pdb:2EKO|rcsb pdb:2OU2|rcsb pdb:4QQG|reactome:R-HSA-201722|reactome:R-HSA-2559586|reactome:R-HSA-3214847|reactome:R-HSA-5685938|ensembl:ENSG00000172977(gene)|ensembl:ENST00000377046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001193762.1|ensembl:ENST00000341318|ensembl:ENSP00000340330|ensembl:ENST00000352980|ensembl:ENSP00000344955|ensembl:ENSP00000366245|ensembl:ENST00000530446|ensembl:ENSP00000434765|dip:DIP-5998N|uniprotkb:Q92993(identity)|human orfeome collection:53941(identity)|ddbj/embl/genbank:BC117167(identity)|entrezgene/locuslink:10524(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:JvtMfge2Q7fuGOTLSWqR3syL/3s9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:289EE91EBC283556|rigid:UQIUPmnG97CUiIxVyjBIXa5vHhc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q92993 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-399080|uniprotkb:O95624|uniprotkb:Q13430|uniprotkb:Q17RW5|uniprotkb:Q6GSE8|uniprotkb:Q9BWK7|uniprotkb:Q561W3|intact:EBI-28987721|ensembl:ENSP00000366245|uniprotkb:C9JL99|uniprotkb:B4E3C7 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:kat5_human(display_long)|uniprotkb:KAT5(gene name)|psi-mi:KAT5(display_short)|uniprotkb:TIP60(gene name synonym)|uniprotkb:HTATIP(gene name synonym)|uniprotkb:Lysine acetyltransferase 5(gene name synonym)|uniprotkb:"cPLA(2)-interacting protein"(gene name synonym)|uniprotkb:Histone acetyltransferase HTATIP(gene name synonym)|uniprotkb:60 kDa Tat-interactive protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382384|imex:IM-22301-1204 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_006379.2|refseq:NP_874368.1|refseq:NP_874369.1|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-9018519|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037995|interpro:IPR040706|rcsb pdb:2EKO|rcsb pdb:2OU2|rcsb pdb:4QQG|reactome:R-HSA-201722|reactome:R-HSA-2559586|reactome:R-HSA-3214847|reactome:R-HSA-5685938|ensembl:ENSG00000172977(gene)|ensembl:ENST00000377046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001193762.1|ensembl:ENST00000341318|ensembl:ENSP00000340330|ensembl:ENST00000352980|ensembl:ENSP00000344955|ensembl:ENSP00000366245|ensembl:ENST00000530446|ensembl:ENSP00000434765|dip:DIP-5998N|uniprotkb:Q92993(identity)|human orfeome collection:53941(identity)|ddbj/embl/genbank:BC117167(identity)|entrezgene/locuslink:10524(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:JvtMfge2Q7fuGOTLSWqR3syL/3s9606 intact-crc:48DED847E01ECB3A|rigid:we1X/6lES8HrppBluBPNLxtMe1I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92993 uniprotkb:Q9BTE6-2 intact:EBI-399080|uniprotkb:O95624|uniprotkb:Q13430|uniprotkb:Q17RW5|uniprotkb:Q6GSE8|uniprotkb:Q9BWK7|uniprotkb:Q561W3|intact:EBI-28987721|ensembl:ENSP00000366245|uniprotkb:C9JL99|uniprotkb:B4E3C7 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:kat5_human(display_long)|uniprotkb:KAT5(gene name)|psi-mi:KAT5(display_short)|uniprotkb:TIP60(gene name synonym)|uniprotkb:HTATIP(gene name synonym)|uniprotkb:Lysine acetyltransferase 5(gene name synonym)|uniprotkb:"cPLA(2)-interacting protein"(gene name synonym)|uniprotkb:Histone acetyltransferase HTATIP(gene name synonym)|uniprotkb:60 kDa Tat-interactive protein(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382403|imex:IM-22301-1205 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006379.2|refseq:NP_874368.1|refseq:NP_874369.1|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-9018519|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037995|interpro:IPR040706|rcsb pdb:2EKO|rcsb pdb:2OU2|rcsb pdb:4QQG|reactome:R-HSA-201722|reactome:R-HSA-2559586|reactome:R-HSA-3214847|reactome:R-HSA-5685938|ensembl:ENSG00000172977(gene)|ensembl:ENST00000377046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_001193762.1|ensembl:ENST00000341318|ensembl:ENSP00000340330|ensembl:ENST00000352980|ensembl:ENSP00000344955|ensembl:ENSP00000366245|ensembl:ENST00000530446|ensembl:ENSP00000434765|dip:DIP-5998N|uniprotkb:Q92993(identity)|human orfeome collection:53941(identity)|ddbj/embl/genbank:BC117167(identity)|entrezgene/locuslink:10524(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JvtMfge2Q7fuGOTLSWqR3syL/3s9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:4BB286FDF4BA3EE2|rigid:Oyu5gYNVAHlc8ja9ALOLsz2MGCQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:P58340 intact:EBI-9382425 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382429|imex:IM-22301-1206 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:3E1ABBFF2111409F|rigid:ghhQtKEdtpaYQ6CO5oComGV7H38 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q93000 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9382425 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382451|imex:IM-22301-1207 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:C3F02992E0628CF9|rigid:DieLaTGxdl+giusV1hngAEmpc7M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:Q6PK50 intact:EBI-9382425 intact:EBI-9356629 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382472|imex:IM-22301-1208 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:347B561F6D80A0DC|rigid:aYL3KeUC0kPSCp8xzlw9yz+qnJo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q93000 intact:EBI-9356749 intact:EBI-9382425 psi-mi:q53fc7_human(display_long) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382494|imex:IM-22301-1209 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:E17D0746601B3D50|rigid:WuSiEUAsxk78V+Fy0QkQL+ZXvxc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:Q03933 intact:EBI-9382425 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382516|imex:IM-22301-1210 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:D7C8168112C4DD30|rigid:Vce2B9D7U9BXv3UiL1iERYbuczE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q93000 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9382425 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382535|imex:IM-22301-1211 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:2CFB058145281031|rigid:LVK7k7oOAnXG3Bnh4NF/aZFXtNc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q93000 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9382425 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382557|imex:IM-22301-1212 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:17B9791ADF0D74DB|rigid:FoxBx1+0AIMEIlZVPrt7wQNQRLU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q93000 intact:EBI-9357028 intact:EBI-9382425 psi-mi:b4dyc6_human(display_long) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382576|imex:IM-22301-1213 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:FAAAEB231F68D55B|rigid:jqCx1LmI3np6VcULSv7afv5cXXU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q93000 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9382425 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382596|imex:IM-22301-1214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:F5118CF0DCA90A0E|rigid:/2FB47AOvd7uXbKaCtX+7FaxKmc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:Q96BE0 intact:EBI-9382425 intact:EBI-9356686 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382618|imex:IM-22301-1215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:305BE1F07441B3E1|rigid:wjaU7sKZQwAVwMUD7bGvYjqrIAY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:P31948 intact:EBI-9382425 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382640|imex:IM-22301-1216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:5BD86B8341BF5D26|rigid:k2GJrcXMphvI9MZBq2N3fzcgjxU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:Q9UNE7 intact:EBI-9382425 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382659|imex:IM-22301-1217 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:FE204456E40D833B|rigid:OiT4a6x0oR5kzU2kzD5LowfMxjs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93000 uniprotkb:Q9HB71 intact:EBI-9382425 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382681|imex:IM-22301-1218 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:8D2B95679ADEF876|rigid:lV2xUDNF1bnYZEzV5f4wnQX7go4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q93000 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9382425 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382700|imex:IM-22301-1219 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:3A909BA47266CFE3|rigid:QoRe/UuZ3w6HXv3TVxADvJd4+dE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q93000 intact:EBI-9356778 intact:EBI-9382425 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:q93000_human(display_long)|uniprotkb:CHLR1(gene name)|psi-mi:CHLR1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382722|imex:IM-22301-1220 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) interpro:IPR028331|interpro:IPR027417|interpro:IPR006554(Helicase-like, DEXD box c2 type)|interpro:IPR006555(Helicase, ATP-dependent, c2 type)|interpro:IPR010614(DEAD2)|interpro:IPR013020("DNA helicase (DNA repair), Rad3 type")|interpro:IPR014013(Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|uniprotkb:Q93000(identity)|ddbj/embl/genbank:BC011264(identity)|human orfeome collection:2444(identity)|entrezgene/locuslink:1663(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:CAUx87wTYLTmjdsqcypZgXV/AJM9606 intact-crc:96A9F2BE1EA36D46|rigid:+QOkR6zhcD5j17/lOzwP9CURPxA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q03933 intact:EBI-9356686 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q96be0_human(display_long) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382744|imex:IM-22301-1221 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:517A50827C82E211|rigid:BPOEA1fiNNQtgbA+heeRXlJn5rg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q96BE0 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-9356686 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382763|imex:IM-22301-1222 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1CADA7BB0D929FB6|rigid:ZeMihVQpuKXzhvV0W/Z5EHlwx+o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q92598 intact:EBI-9356686 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:q96be0_human(display_long) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382785|imex:IM-22301-1223 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453|uniprotkb:Q92598(identity)|ddbj/embl/genbank:BC037553(identity)|entrezgene/locuslink:10808(identity)|human orfeome collection:9615(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:B81E0E389A4CAC07|rigid:3rm3R2tzgwSpooRk1Va3c0y/eWA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9BTE6-2 intact:EBI-9356686 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q96be0_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382807|imex:IM-22301-1224 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:5019BD6E8A076E97|rigid:4sg692vg5NMpE3JYitrLtjCvmWQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99614 uniprotkb:Q96BE0 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-9356686 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382829|imex:IM-22301-1225 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:47BF38C1C4172E26|rigid:gt1vkX8WcUDd7L23P8AT6kdD5iQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BQ3 uniprotkb:P58340 intact:EBI-2129899|uniprotkb:Q53TJ7|ensembl:ENSP00000272395 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:tri43_human(display_long)|uniprotkb:TRIM43(gene name)|psi-mi:TRIM43(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382848|imex:IM-22301-1226 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620155.1|ensembl:ENSG00000144015(gene)|ensembl:ENST00000272395(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|uniprotkb:Q96BQ3(identity)|human orfeome collection:431(identity)|entrezgene/locuslink:129868(identity)|ddbj/embl/genbank:BC015353(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pfo60amX0NFspl9zqQ/Cgek6yO09606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:60A8823FCD3921B6|rigid:JrzVIq0CdqdhQIjXgTVM6BJP8Dw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BQ3 uniprotkb:Q9HB71 intact:EBI-2129899|uniprotkb:Q53TJ7|ensembl:ENSP00000272395 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:tri43_human(display_long)|uniprotkb:TRIM43(gene name)|psi-mi:TRIM43(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382870|imex:IM-22301-1227 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620155.1|ensembl:ENSG00000144015(gene)|ensembl:ENST00000272395(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|uniprotkb:Q96BQ3(identity)|human orfeome collection:431(identity)|entrezgene/locuslink:129868(identity)|ddbj/embl/genbank:BC015353(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pfo60amX0NFspl9zqQ/Cgek6yO09606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:E6C7BEB7E7DA7328|rigid:R9o5jWa81RlgY10CJH6O7GIJCWA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96C12 uniprotkb:Q8K2C9 intact:EBI-6425121|ensembl:ENSP00000268314|ensembl:ENSP00000456877|uniprotkb:Q86WM9|uniprotkb:Q9H925|uniprotkb:Q9H7P8 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 psi-mi:armc5_human(display_long)|uniprotkb:ARMC5(gene name)|psi-mi:ARMC5(display_short) psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382889|imex:IM-22301-1228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140691(gene)|ensembl:ENST00000268314(transcript)|ensembl:ENST00000563544(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0016020"(membrane)|go:"GO:0035801"(adrenal cortex development)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0051607"(defense response to virus)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000225(Armadillo)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001288749.1|refseq:NP_001275696.1|refseq:NP_001098717.1|refseq:NP_079018.1|uniprotkb:Q96C12(identity)|human orfeome collection:7626(identity)|ddbj/embl/genbank:BC014945(identity)|entrezgene/locuslink:79798(identity) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZmP+cRk6jHF3CzosogoO2kQOnF89606 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 intact-crc:086B3E89CCB7643C|rigid:J/unRD1wMCopsYvVbS/lkIGYrFk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96C12 uniprotkb:Q53FC7 intact:EBI-6425121|ensembl:ENSP00000268314|ensembl:ENSP00000456877|uniprotkb:Q86WM9|uniprotkb:Q9H925|uniprotkb:Q9H7P8 intact:EBI-9356749 psi-mi:armc5_human(display_long)|uniprotkb:ARMC5(gene name)|psi-mi:ARMC5(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382910|imex:IM-22301-1229 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140691(gene)|ensembl:ENST00000268314(transcript)|ensembl:ENST00000563544(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0016020"(membrane)|go:"GO:0035801"(adrenal cortex development)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0051607"(defense response to virus)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000225(Armadillo)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001288749.1|refseq:NP_001275696.1|refseq:NP_001098717.1|refseq:NP_079018.1|uniprotkb:Q96C12(identity)|human orfeome collection:7626(identity)|ddbj/embl/genbank:BC014945(identity)|entrezgene/locuslink:79798(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZmP+cRk6jHF3CzosogoO2kQOnF89606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:921504DFAC99EF78|rigid:F6isL+XqLYNe3HtPO55A9cUu+Zw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96C12 uniprotkb:Q96BE0 intact:EBI-6425121|ensembl:ENSP00000268314|ensembl:ENSP00000456877|uniprotkb:Q86WM9|uniprotkb:Q9H925|uniprotkb:Q9H7P8 intact:EBI-9356686 psi-mi:armc5_human(display_long)|uniprotkb:ARMC5(gene name)|psi-mi:ARMC5(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382932|imex:IM-22301-1230 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140691(gene)|ensembl:ENST00000268314(transcript)|ensembl:ENST00000563544(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0016020"(membrane)|go:"GO:0035801"(adrenal cortex development)|go:"GO:0042098"(T cell proliferation)|go:"GO:0043367"(CD4-positive, alpha-beta T cell differentiation)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0051607"(defense response to virus)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000225(Armadillo)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001288749.1|refseq:NP_001275696.1|refseq:NP_001098717.1|refseq:NP_079018.1|uniprotkb:Q96C12(identity)|human orfeome collection:7626(identity)|ddbj/embl/genbank:BC014945(identity)|entrezgene/locuslink:79798(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ZmP+cRk6jHF3CzosogoO2kQOnF89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:2320B000FB416793|rigid:+JfNOXw4uolaMn/5Zg4/LX5dTvE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96C36 uniprotkb:Q9UIM3 intact:EBI-358366|uniprotkb:Q7Z515|uniprotkb:Q9Y5J4|ensembl:ENSP00000342502|uniprotkb:A8K798 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:p5cr2_human(display_long)|uniprotkb:PYCR2(gene name)|psi-mi:PYCR2(display_short) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382954|imex:IM-22301-1231 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037460.2|ensembl:ENSG00000143811(gene)|ensembl:ENST00000343818(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR028939|interpro:IPR029036|interpro:IPR036291|mint:Q96C36|rcsb pdb:6LHM|reactome:R-HSA-8964539|refseq:NP_001258610.1|uniprotkb:Q96C36(identity)|human orfeome collection:430(identity)|entrezgene/locuslink:29920(identity)|ddbj/embl/genbank:BC014868(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lIjn88RdpxuNpN+fgVPZV2bjubA9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:4540C18B6FBC28D6|rigid:cJSNwXtLZBeaSP0aWO/THXrCxOI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:P62495 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382973|imex:IM-22301-1232 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:Q96CG1(identity)|entrezgene/locuslink:2107(identity)|human orfeome collection:6150(identity)|ddbj/embl/genbank:BC014269(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606 intact-crc:4DC11A5DCFBD399F|rigid:YxRgjavrENHe2vuKgUcwRtVm/KU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62495 uniprotkb:Q15773 intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9382995|imex:IM-22301-1233 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:Q96CG1(identity)|entrezgene/locuslink:2107(identity)|human orfeome collection:6150(identity)|ddbj/embl/genbank:BC014269(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:BF673179CC2B61D3|rigid:405riO1ofZiuwJbnCoc7iT6DYvg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:P62495 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383017|imex:IM-22301-1234 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:Q96CG1(identity)|entrezgene/locuslink:2107(identity)|human orfeome collection:6150(identity)|ddbj/embl/genbank:BC014269(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606 intact-crc:3D88A76F6E27F34C|rigid:3nrv0hgaVWSr/pZcdakrJTM8nGo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P62495 uniprotkb:Q9UIM3 intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383039|imex:IM-22301-1235 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:Q96CG1(identity)|entrezgene/locuslink:2107(identity)|human orfeome collection:6150(identity)|ddbj/embl/genbank:BC014269(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:C4A89AA2A493E292|rigid:DmWsnpkHD50JRi9gePXR88CgY7o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q96CW5 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1046278|ensembl:ENSP00000261965|uniprotkb:O43631|uniprotkb:O60852|uniprotkb:O60853|uniprotkb:Q7Z4K1|uniprotkb:Q96I79|uniprotkb:Q5T8L2 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:gcp3_human(display_long)|uniprotkb:Spindle pole body protein Spc98 homolog(gene name synonym)|uniprotkb:TUBGCP3(gene name)|psi-mi:TUBGCP3(display_short)|uniprotkb:GCP3(gene name synonym)|uniprotkb:Gamma-ring complex protein 104 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383058|imex:IM-22301-1236 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007338"(single fertilization)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q96CW5|rcsb pdb:6V6B|go:"GO:0000930"(gamma-tubulin complex)|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSG00000126216(gene)|ensembl:ENST00000261965(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_006313.1|refseq:NP_001273207.1|refseq:NP_001273208.1|refseq:NP_001273206.1|uniprotkb:Q96CW5(identity)|ddbj/embl/genbank:BC013781(identity)|human orfeome collection:2984(identity)|entrezgene/locuslink:10426(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:xt+Ngo2s/4djh2PnyMEaxgDyLrs9606 intact-crc:B89995B5012D9A5D|rigid:/5Up5dv2tWtXaTuqO0LH9FAqDAM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q96CW5 intact:EBI-9356686 intact:EBI-1046278|ensembl:ENSP00000261965|uniprotkb:O43631|uniprotkb:O60852|uniprotkb:O60853|uniprotkb:Q7Z4K1|uniprotkb:Q96I79|uniprotkb:Q5T8L2 psi-mi:q96be0_human(display_long) psi-mi:gcp3_human(display_long)|uniprotkb:Spindle pole body protein Spc98 homolog(gene name synonym)|uniprotkb:TUBGCP3(gene name)|psi-mi:TUBGCP3(display_short)|uniprotkb:GCP3(gene name synonym)|uniprotkb:Gamma-ring complex protein 104 kDa(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383079|imex:IM-22301-1237 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007338"(single fertilization)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q96CW5|rcsb pdb:6V6B|go:"GO:0000930"(gamma-tubulin complex)|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSG00000126216(gene)|ensembl:ENST00000261965(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_006313.1|refseq:NP_001273207.1|refseq:NP_001273208.1|refseq:NP_001273206.1|uniprotkb:Q96CW5(identity)|ddbj/embl/genbank:BC013781(identity)|human orfeome collection:2984(identity)|entrezgene/locuslink:10426(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:xt+Ngo2s/4djh2PnyMEaxgDyLrs9606 intact-crc:5585A97C78060879|rigid:IYrGYkt5puDU57O1kzp+zEB4eDs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q96FT7 intact:EBI-9357141 intact:EBI-9116154|uniprotkb:Q53SB7|uniprotkb:Q6GMS1|uniprotkb:Q6PIN9|uniprotkb:Q9NQA4|ensembl:ENSP00000326627|ensembl:ENSP00000350786 psi-mi:q9hav2_human(display_long) psi-mi:asic4_human(display_long)|uniprotkb:ASIC4(gene name)|psi-mi:ASIC4(display_short)|uniprotkb:ACCN4(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 4(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 4, pituitary(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383101|imex:IM-22301-1238 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_878267.2|refseq:NP_061144.3|ensembl:ENSG00000072182(gene)|ensembl:ENST00000347842(transcript)|ensembl:ENST00000358078(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005216"(ion channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015081"(sodium ion transmembrane transporter activity)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0035725"(sodium ion transmembrane transport)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR020903|reactome:R-HSA-2672351|uniprotkb:Q96FT7(identity)|entrezgene/locuslink:55515(identity)|human orfeome collection:2933(identity)|ddbj/embl/genbank:BC010439(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:OcbAo7Wd1Y9h3U/BN5ClRI/NWYY9606 intact-crc:DB69CA3C8E5B1E52|rigid:QF0obMR8EWy59KlDO/F9tJc9EhA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96GD4 uniprotkb:Q6PK50 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 intact:EBI-9356629 psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383123|imex:IM-22301-1239 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N|uniprotkb:Q96GD4(identity)|ddbj/embl/genbank:BC009751(identity)|human orfeome collection:6175(identity)|entrezgene/locuslink:9212(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:502F2925D3FE9AC6|rigid:a7Q2UgTlfRnBQHhVGgxInHZZc64 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q96GD4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383145|imex:IM-22301-1240 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N|uniprotkb:Q96GD4(identity)|ddbj/embl/genbank:BC009751(identity)|human orfeome collection:6175(identity)|entrezgene/locuslink:9212(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 intact-crc:D4CB42945A54F8BA|rigid:i+qw+LCsv/2AY+5iGVDLiJ+z1W4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96II5 uniprotkb:P58340 intact:EBI-9383168|uniprotkb:A6NIT1 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383165|imex:IM-22301-1241 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:2FB8B9A59008F541|rigid:jC40GbxVtD0HvoU1TwzzRwy097o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q96II5 intact:EBI-9356629 intact:EBI-9383168|uniprotkb:A6NIT1 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383192|imex:IM-22301-1242 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 intact-crc:E5C8C4DB5A286503|rigid:jp5hyoWKtTc1x9+3LaZm/72zQOQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q96II5 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-9383168|uniprotkb:A6NIT1 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383214|imex:IM-22301-1243 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 intact-crc:17656B5851993B50|rigid:u5W3PnZHX+cb326kYCrA+D/P9a8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RS6 uniprotkb:Q96II5 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-9383168|uniprotkb:A6NIT1 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383235|imex:IM-22301-1244 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 intact-crc:33E14BDA850AD5AB|rigid:JgGYXljWvXNyGV6qb0C/jr5uuo4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q96II5 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9383168|uniprotkb:A6NIT1 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383254|imex:IM-22301-1245 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 intact-crc:9946D8AFF95920FD|rigid:oaYfGG0cv3S3QwB570PYG0M+8qo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96II5 uniprotkb:Q9BPW0 intact:EBI-9383168|uniprotkb:A6NIT1 intact:EBI-9356778 psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383276|imex:IM-22301-1246 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|ddbj/embl/genbank:BC007514(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:40FF9D97176DF0E1|rigid:c6ueabrRjgczl+08JLoD54yFQHo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q13451 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383298|imex:IM-22301-1247 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:DD7D696235887D76|rigid:ZxBVrP8FGKQIkECZUXeLCxz9u8Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q6PK50 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-9356629 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383317|imex:IM-22301-1248 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:638A1A5C01EA621D|rigid:PWOBevtxIpGPU4AdUs2+jM9dckg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q03933 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383339|imex:IM-22301-1249 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:99B642361C3BA55E|rigid:xvaVNZOvF0QWj/CEJyUFBMikGMY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q9Y266 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383358|imex:IM-22301-1250 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:78D36C945D4F2FD0|rigid:vtDA4RBhmpzYRbRh/PJwMY1NA6E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q8IVD9 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383377|imex:IM-22301-1251 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:E50BA50348713D47|rigid:R034XMdQ4Zsl3rZl/kujcnP2On8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:B4DYC6 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-9357028 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383396|imex:IM-22301-1252 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:7B4300CD09EFD8D8|rigid:prM5g+CEyxZOJUMVriz1beDqhmk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q96BE0 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-9356686 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383416|imex:IM-22301-1253 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:1566D1A76F88C843|rigid:tIHZiYthd/K4WgVeQh6h4e4o3tk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:P07900 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383438|imex:IM-22301-1254 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:BA31EDED991152EA|rigid:oJ/VVCBbsndO8tzdS/c5Ky8vQ2o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q9HB71 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383459|imex:IM-22301-1255 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:90A7CFC659BCF8A2|rigid:3J9BJ+0lKVo4g0mcqVXiWY+o+E8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q15185 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383478|imex:IM-22301-1256 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:397DC6211D15FC2E|rigid:+WEulN9GF1j/4GOO5AfzmF4Hh28 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J94 uniprotkb:Q9BPW0 intact:EBI-527417|uniprotkb:O95404|uniprotkb:Q8NA60|uniprotkb:Q8TBY5|uniprotkb:Q96JD5|uniprotkb:A4F266|ensembl:ENSP00000245255|ensembl:ENSP00000481042 intact:EBI-9356778 psi-mi:piwl1_human(display_long)|uniprotkb:PIWIL1(gene name)|psi-mi:PIWIL1(display_short)|uniprotkb:HIWI(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383498|imex:IM-22301-1257 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33534N|refseq:NP_001177900.1|refseq:NP_004755.2|refseq:XP_011537304.1|refseq:XP_011537305.1|refseq:XP_011537306.1|rcsb pdb:3O6E|rcsb pdb:3O7V|ensembl:ENSG00000125207(gene)|ensembl:ENSG00000275051(gene)|ensembl:ENST00000245255(transcript)|ensembl:ENST00000613226(transcript)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034584"(piRNA binding)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0035093"(spermatogenesis, exchange of chromosomal proteins)|go:"GO:0043186"(P granule)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0097433"(dense body)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1905538"(polysome binding)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR031320|interpro:IPR031326|interpro:IPR036085|interpro:IPR036397|mint:Q96J94|rcsb pdb:2L5C|rcsb pdb:2L5D|rcsb pdb:3O3I|rcsb pdb:6PI7|reactome:R-HSA-5601884|uniprotkb:Q96J94(identity)|human orfeome collection:1531(identity)|entrezgene/locuslink:9271(identity)|ddbj/embl/genbank:BC028581(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:cffy1VShng63XG+ArewNgwF/RQM9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:27F353178990DEF0|rigid:sjZCl1uzVKzgs9pR674Q1XgTEqM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96K97 uniprotkb:Q96BE0 intact:EBI-9383523 intact:EBI-9356686 psi-mi:q96k97_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383520|imex:IM-22301-1258 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR026258|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|uniprotkb:Q96K97(identity)|ddbj/embl/genbank:BC020238(identity)|entrezgene/locuslink:6730(identity)|human orfeome collection:12621(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:BZbMc87UPZQwG7UZqZKf0q3sCxM9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:5AF3D459F1DBA70A|rigid:Mftk2QaIU4BSnsPgUwuTS/5Kds4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75344 uniprotkb:Q96MX6 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-2434101|uniprotkb:Q96CR6|ensembl:ENSP00000295121 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:daa10_human(display_long)|uniprotkb:DNAAF10(gene name)|psi-mi:DNAAF10(display_short)|uniprotkb:WD repeat-containing protein 92(gene name synonym)|uniprotkb:WD repeat-containing protein Monad(gene name synonym)|uniprotkb:WDR92(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383545|imex:IM-22301-1259 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity)|human orfeome collection:10177(identity) refseq:NP_612467.1|refseq:NP_001243405.1|ensembl:ENSG00000243667(gene)|ensembl:ENST00000295121(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q96MX6|rcsb pdb:3I2N|uniprotkb:Q96MX6(identity)|human orfeome collection:13486(identity)|entrezgene/locuslink:116143(identity)|ddbj/embl/genbank:BC014022(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:mMEdSK0cmIF+8Bayok/snQBKYMg9606 intact-crc:3A557EE70D5DB1A0|rigid:TIz7LR9c9x/Oika4at+ibv8wwdw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96P23 uniprotkb:Q13200 intact:EBI-2555185 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:q96p23_human(display_long) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383567|imex:IM-22301-1260 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|interpro:IPR031833|uniprotkb:Q96P23(identity)|entrezgene/locuslink:25953(identity)|ddbj/embl/genbank:BC036457(identity)|human orfeome collection:1671(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uyH6M3FXptpi3grboxBmax/fhjA9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:0ED6820BC0913687|rigid:ubTKPaZ7Mcg6vLK3VmSnbR9fTjQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q96PK0 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9383589 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q96pk0_human(display_long)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383593|imex:IM-22301-1261 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) uniprotkb:Q96PK0(identity)|human orfeome collection:6504(identity)|entrezgene/locuslink:26958(identity)|ddbj/embl/genbank:BC017443(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:CxNPaTHvB9xuJOwX1FQ+XyZk+XU9606 intact-crc:9CA148F5C66976D9|rigid:q7o9uhGyELTwEdbp+hl15G4XwgY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q96PK0 intact:EBI-9356629 intact:EBI-9383589 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q96pk0_human(display_long)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383615|imex:IM-22301-1262 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) uniprotkb:Q96PK0(identity)|human orfeome collection:6504(identity)|entrezgene/locuslink:26958(identity)|ddbj/embl/genbank:BC017443(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:CxNPaTHvB9xuJOwX1FQ+XyZk+XU9606 intact-crc:691D0539A1C673CF|rigid:yEP6DhdB/PTPfBSb/sRtd77cKs8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PK0 uniprotkb:Q96BE0 intact:EBI-9383589 intact:EBI-9356686 psi-mi:q96pk0_human(display_long)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383637|imex:IM-22301-1263 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q96PK0(identity)|human orfeome collection:6504(identity)|entrezgene/locuslink:26958(identity)|ddbj/embl/genbank:BC017443(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CxNPaTHvB9xuJOwX1FQ+XyZk+XU9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:BE16B79E7FB1DF39|rigid:SaSxwo4jEhE1lJW/hX8IW/Zen8Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PK0 uniprotkb:Q96RS6 intact:EBI-9383589 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:q96pk0_human(display_long)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383659|imex:IM-22301-1264 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q96PK0(identity)|human orfeome collection:6504(identity)|entrezgene/locuslink:26958(identity)|ddbj/embl/genbank:BC017443(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CxNPaTHvB9xuJOwX1FQ+XyZk+XU9606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:6B0E54A34550ED6A|rigid:9itJYua68gBtrCjKghBeBsprxS8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q96Q40 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1051975|uniprotkb:Q53TV1|uniprotkb:Q4ZG86|uniprotkb:Q6ZMR9|uniprotkb:Q8IUP1|uniprotkb:B8ZZX0|uniprotkb:C9J1N8|uniprotkb:C9K003|uniprotkb:A8K8R9|uniprotkb:F8W6H8|ensembl:ENSP00000498608 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cdk15_human(display_long)|uniprotkb:ALS2CR7(gene name synonym)|uniprotkb:Serine/threonine-protein kinase ALS2CR7(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein(gene name synonym)|uniprotkb:CDK15(gene name)|psi-mi:CDK15(display_short)|uniprotkb:PFTK2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PFTAIRE-2(gene name synonym)|uniprotkb:Cell division protein kinase 15(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383678|imex:IM-22301-1265 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_001248364.1|refseq:NP_631897.1|refseq:NP_001248365.1|refseq:XP_005246838.1|refseq:XP_005246839.1|ensembl:ENST00000652192(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042761|ensembl:ENSG00000138395(gene)|uniprotkb:Q96Q40(identity)|ddbj/embl/genbank:BC038807(identity)|entrezgene/locuslink:65061(identity)|human orfeome collection:11154(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:ceURrVNJCJYYLumA/a7VLDbE1Eg9606 intact-crc:7C863A352904D38E|rigid:5dGgCc9+agIe1ZN89vTAXei4Pvk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96Q40 uniprotkb:P07900 intact:EBI-1051975|uniprotkb:Q53TV1|uniprotkb:Q4ZG86|uniprotkb:Q6ZMR9|uniprotkb:Q8IUP1|uniprotkb:B8ZZX0|uniprotkb:C9J1N8|uniprotkb:C9K003|uniprotkb:A8K8R9|uniprotkb:F8W6H8|ensembl:ENSP00000498608 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:cdk15_human(display_long)|uniprotkb:ALS2CR7(gene name synonym)|uniprotkb:Serine/threonine-protein kinase ALS2CR7(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein(gene name synonym)|uniprotkb:CDK15(gene name)|psi-mi:CDK15(display_short)|uniprotkb:PFTK2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PFTAIRE-2(gene name synonym)|uniprotkb:Cell division protein kinase 15(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383697|imex:IM-22301-1266 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001248364.1|refseq:NP_631897.1|refseq:NP_001248365.1|refseq:XP_005246838.1|refseq:XP_005246839.1|ensembl:ENST00000652192(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042761|ensembl:ENSG00000138395(gene)|uniprotkb:Q96Q40(identity)|ddbj/embl/genbank:BC038807(identity)|entrezgene/locuslink:65061(identity)|human orfeome collection:11154(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ceURrVNJCJYYLumA/a7VLDbE1Eg9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:6104FC472E8C16A9|rigid:gJogrbf1v0oFYFTeoAb6G3OOiB4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96QS6 uniprotkb:Q53FC7 intact:EBI-6424813|ensembl:ENSP00000276616|uniprotkb:A0AV22 intact:EBI-9356749 psi-mi:kpsh2_human(display_long)|uniprotkb:PSKH2(gene name)|psi-mi:PSKH2(display_short)|uniprotkb:Protein serine kinase H2(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383718|imex:IM-22301-1267 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147613(gene)|ensembl:ENST00000276616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_149117.1|uniprotkb:Q96QS6(identity)|human orfeome collection:54299(identity)|entrezgene/locuslink:85481(identity)|ddbj/embl/genbank:BC126180(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tcOISTrdxixiVCnoNMW/knj1Vmo9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:639A732DE44FD1BA|rigid:ltqTBiICmuf9s4hhkPsAMYynsXw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96QS6 uniprotkb:Q13200 intact:EBI-6424813|ensembl:ENSP00000276616|uniprotkb:A0AV22 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:kpsh2_human(display_long)|uniprotkb:PSKH2(gene name)|psi-mi:PSKH2(display_short)|uniprotkb:Protein serine kinase H2(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383740|imex:IM-22301-1268 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147613(gene)|ensembl:ENST00000276616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_149117.1|uniprotkb:Q96QS6(identity)|human orfeome collection:54299(identity)|entrezgene/locuslink:85481(identity)|ddbj/embl/genbank:BC126180(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tcOISTrdxixiVCnoNMW/knj1Vmo9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:A0D616B5590A9C19|rigid:4dSmrVInqNIz/kKScwKVdkIqMX4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96QS6 uniprotkb:P07900 intact:EBI-6424813|ensembl:ENSP00000276616|uniprotkb:A0AV22 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:kpsh2_human(display_long)|uniprotkb:PSKH2(gene name)|psi-mi:PSKH2(display_short)|uniprotkb:Protein serine kinase H2(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383762|imex:IM-22301-1269 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147613(gene)|ensembl:ENST00000276616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_149117.1|uniprotkb:Q96QS6(identity)|human orfeome collection:54299(identity)|entrezgene/locuslink:85481(identity)|ddbj/embl/genbank:BC126180(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tcOISTrdxixiVCnoNMW/knj1Vmo9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:BEA6F5EB9CBE94A8|rigid:HV7g3fO+irfSh/9uJhDq/V5wYQE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q96QU5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9383786 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q96qu5_human(display_long)|uniprotkb:PLOD2(gene name)|psi-mi:PLOD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383783|imex:IM-22301-1270 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) uniprotkb:Q96QU5(identity)|ddbj/embl/genbank:BC037169(identity)|human orfeome collection:9763(identity)|entrezgene/locuslink:5352(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:OOhQzZlwgycqf4gC41j9HZydhgo9606 intact-crc:6AE81237AA6F7E93|rigid:nYTFYW3TyG8/ei3fmvY5s49yrvw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q96S08 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9383806 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383811|imex:IM-22301-1271 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:3E8E4F8DB69316CC|rigid:Ed22uRyyhJsd+0O4hFQILdQPnKI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S08 uniprotkb:Q03933 intact:EBI-9383806 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383832|imex:IM-22301-1272 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:A3C447B1335BEC50|rigid:OOOyYA3qbrGGUHT0o/RcygxqLKE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q96S08 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-9383806 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383851|imex:IM-22301-1273 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:60E5C8B0F1173676|rigid:J9H8Lvg5jVHPgePUf5aRcgkiaHU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q96S08 intact:EBI-9357141 intact:EBI-9383806 psi-mi:q9hav2_human(display_long) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383873|imex:IM-22301-1274 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:1E287D91A3985727|rigid:SSooriB2zXdFxBDSoMoRhjRXtU8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q96S08 intact:EBI-9356686 intact:EBI-9383806 psi-mi:q96be0_human(display_long) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383917|imex:IM-22301-1276 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:9338844C82A1926E|rigid:MUqXFRXbFt6mih1pjem9KKU1L48 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q96S08 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-9383806 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383895|imex:IM-22301-1275 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:A908861FC55392F2|rigid:z9SJow7tlRQ4I+R/k/hpG+dRCDY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q96S08 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9383806 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383939|imex:IM-22301-1277 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:055A8B70ADA9F8A9|rigid:6Xj00xajSYMCpLO/AKw3dI5rD90 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S08 uniprotkb:Q9HB71 intact:EBI-9383806 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383961|imex:IM-22301-1278 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:1F5A70168C66B49F|rigid:HcrIZYJseu7KLlwgSI88UP+cLUE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q96S08 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9383806 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q96s08_human(display_long)|uniprotkb:RUVBL(gene name)|psi-mi:RUVBL(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9383980|imex:IM-22301-1279 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|uniprotkb:Q96S08(identity)|human orfeome collection:2459(identity)|entrezgene/locuslink:63922(identity)|ddbj/embl/genbank:BC018184(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:w8DvlUUd+0iMpHskwuZUy+/uY0s9606 intact-crc:E9568EDCFDA7DB8D|rigid:P5A/Ig7aeFSELfQvjCxlOy+J634 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S53-3 uniprotkb:P07900 intact:EBI-9384005|ensembl:ENSP00000361156 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q96s53-3(display_long)|uniprotkb:TESK2(gene name)|psi-mi:TESK2(display_short)|uniprotkb:Testicular protein kinase 2(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384002|imex:IM-22301-1280 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1384110(isoform-parent)|ensembl:ENSG00000070759(gene)|ensembl:ENST00000372084(transcript)|uniprotkb:Q96S53-3(identity)|human orfeome collection:13531(identity)|entrezgene/locuslink:10420(identity)|ddbj/embl/genbank:BC033085(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mlcdycjL3+Wp1F2JCZCWyqPEuts9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:AD8CD0B98A90FFB2|rigid:2/Dqv4GFMjlyFymscR7zlih7vlo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S53-3 uniprotkb:Q13451 intact:EBI-9384005|ensembl:ENSP00000361156 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q96s53-3(display_long)|uniprotkb:TESK2(gene name)|psi-mi:TESK2(display_short)|uniprotkb:Testicular protein kinase 2(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384027|imex:IM-22301-1281 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1384110(isoform-parent)|ensembl:ENSG00000070759(gene)|ensembl:ENST00000372084(transcript)|uniprotkb:Q96S53-3(identity)|human orfeome collection:13531(identity)|entrezgene/locuslink:10420(identity)|ddbj/embl/genbank:BC033085(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mlcdycjL3+Wp1F2JCZCWyqPEuts9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:AFD263B0AD76744C|rigid:sJBcSKtbtbE448CV1iQsJfZr4yA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S53-3 uniprotkb:Q6PK50 intact:EBI-9384005|ensembl:ENSP00000361156 intact:EBI-9356629 psi-mi:q96s53-3(display_long)|uniprotkb:TESK2(gene name)|psi-mi:TESK2(display_short)|uniprotkb:Testicular protein kinase 2(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384046|imex:IM-22301-1282 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1384110(isoform-parent)|ensembl:ENSG00000070759(gene)|ensembl:ENST00000372084(transcript)|uniprotkb:Q96S53-3(identity)|human orfeome collection:13531(identity)|entrezgene/locuslink:10420(identity)|ddbj/embl/genbank:BC033085(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mlcdycjL3+Wp1F2JCZCWyqPEuts9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:617D0ADFBF36F582|rigid:TUrv0uWaXaJ0KNHzjV4IYJ/+uvQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q96S53-3 intact:EBI-9356686 intact:EBI-9384005|ensembl:ENSP00000361156 psi-mi:q96be0_human(display_long) psi-mi:q96s53-3(display_long)|uniprotkb:TESK2(gene name)|psi-mi:TESK2(display_short)|uniprotkb:Testicular protein kinase 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384068|imex:IM-22301-1283 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) intact:EBI-1384110(isoform-parent)|ensembl:ENSG00000070759(gene)|ensembl:ENST00000372084(transcript)|uniprotkb:Q96S53-3(identity)|human orfeome collection:13531(identity)|entrezgene/locuslink:10420(identity)|ddbj/embl/genbank:BC033085(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:mlcdycjL3+Wp1F2JCZCWyqPEuts9606 intact-crc:E998DFF378CB5141|rigid:SAFts3T49/RKRkvHKfeBJBdp24A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96S53-3 uniprotkb:Q16543 intact:EBI-9384005|ensembl:ENSP00000361156 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:q96s53-3(display_long)|uniprotkb:TESK2(gene name)|psi-mi:TESK2(display_short)|uniprotkb:Testicular protein kinase 2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384090|imex:IM-22301-1284 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1384110(isoform-parent)|ensembl:ENSG00000070759(gene)|ensembl:ENST00000372084(transcript)|uniprotkb:Q96S53-3(identity)|human orfeome collection:13531(identity)|entrezgene/locuslink:10420(identity)|ddbj/embl/genbank:BC033085(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mlcdycjL3+Wp1F2JCZCWyqPEuts9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:3F77E290967AF709|rigid:yPxpVReud0yvdx/ouiEGD49niIA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99615 uniprotkb:Q15773 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384110|imex:IM-22301-1285 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:EF02847FBFD2FFA7|rigid:Sh2J8SVyBhPd2vTdh+g8SCOls8g false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q99615 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384154|imex:IM-22301-1287 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:9ABD6D93A1F7570F|rigid:OpgV6vIfjL95GqCrC+o1nl49NqM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99615 uniprotkb:O95429 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384132|imex:IM-22301-1286 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|human orfeome collection:10352(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:778FCD9F5C7E909A|rigid:As1xCDU9kAZejKK5IAjC9FGthls false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q99615 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384176|imex:IM-22301-1288 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|human orfeome collection:7073(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:526C2063F73A3E4F|rigid:w71mn9+kCPWC3MuWTirI5bCmGH0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:P58340 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384198|imex:IM-22301-1289 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:5F392BC6095EB82A|rigid:hxS9mhOIdCip4Izj/GkqzNfrhXM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q99933 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384220|imex:IM-22301-1290 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:B8FD2AF4AEAFA69C|rigid:doWBdZkzkMWc/SHS19slAtxhoa4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q99933 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384241|imex:IM-22301-1291 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:EB71ED350B2A6195|rigid:oAftUUTVASlGjrjigQwTgNbmM8s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q53FC7 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-9356749 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384263|imex:IM-22301-1292 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:84073D00F42F95BE|rigid:B3jJuxN5pPxlTOh5MqIhWqCqTgo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q03933 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384285|imex:IM-22301-1293 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:F3BBDC28F81F36E2|rigid:tXLLoZ/32IAwWD1leaKKJnno55k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q9HAV2 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-9357141 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384304|imex:IM-22301-1294 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:EA576507A9A12BBB|rigid:d6OgUxOIxlthe7NHze1k/TEg1fo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q13200 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384326|imex:IM-22301-1295 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:246EA699D6743DB6|rigid:YFtAL0z9EZpHEM5mKovrC/IZ0QM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q3UJD6-1 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384348|imex:IM-22301-1296 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:78E7B1104637C12C|rigid:ap+Mx9hvA0JkT5Lg49Upbjrbrl0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q99933 intact:EBI-9356686 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 psi-mi:q96be0_human(display_long) psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384369|imex:IM-22301-1297 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 intact-crc:72B50C2F4FA2FA50|rigid:ZeMihVQpuKXzhvV0W/Z5EHlwx+o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99933 uniprotkb:Q9UNE7 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384391|imex:IM-22301-1298 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|human orfeome collection:413(identity)|entrezgene/locuslink:573(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:A2C3D6161A4CEB26|rigid:2Hw+AncuPPJma52DXsAdy5twAQg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9BPW0 intact:EBI-9356629 intact:EBI-9356778 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384413|imex:IM-22301-1299 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:92A2D2594C836DC4|rigid:y7fhg3XRySKvIT/T/SiNyQo1o0Q false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9BPW0 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9356778 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384435|imex:IM-22301-1300 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:25AD6B608D3AE866|rigid:xXWZjgy+r7lDzMJwhYPXLKr5X8I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRZ2 uniprotkb:Q13451 intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384454|imex:IM-22301-1301 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975|uniprotkb:Q9BRZ2(identity)|human orfeome collection:13605(identity)|entrezgene/locuslink:81844(identity)|ddbj/embl/genbank:BC048194(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:36BDDA1B60D4ABF9|rigid:WFmY+R2+MbsCine/4K2LOx7ID2I false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRZ2 uniprotkb:Q6PK50 intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161 intact:EBI-9356629 psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384473|imex:IM-22301-1302 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975|uniprotkb:Q9BRZ2(identity)|human orfeome collection:13605(identity)|entrezgene/locuslink:81844(identity)|ddbj/embl/genbank:BC048194(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:0DA89F3AFD4E50E2|rigid:hQCW7wu6MyRgt60QR1kiF/juPGc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9BRZ2 intact:EBI-9357028 intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161 psi-mi:b4dyc6_human(display_long) psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384495|imex:IM-22301-1303 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975|uniprotkb:Q9BRZ2(identity)|human orfeome collection:13605(identity)|entrezgene/locuslink:81844(identity)|ddbj/embl/genbank:BC048194(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606 intact-crc:F56ADBC3FD070A17|rigid:v0SqpVIyTNn3Hn/sPI0uaM8o62U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRZ2 uniprotkb:P07900 intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384515|imex:IM-22301-1304 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975|uniprotkb:Q9BRZ2(identity)|human orfeome collection:13605(identity)|entrezgene/locuslink:81844(identity)|ddbj/embl/genbank:BC048194(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:DCA8BDA32199D1D4|rigid:II3DR7zr4SJWTLjGGfBblePCAw8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BRZ2 uniprotkb:Q15185 intact:EBI-1048636|uniprotkb:Q6PJS5|uniprotkb:Q86VT6|uniprotkb:Q8N2H8|uniprotkb:Q8NAC0|uniprotkb:Q9H031|intact:EBI-2129929|ensembl:ENSP00000305161 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:tri56_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM56(gene name synonym)|uniprotkb:RING finger protein 109(gene name synonym)|uniprotkb:TRIM56(gene name)|psi-mi:TRIM56(display_short)|uniprotkb:RNF109(gene name synonym)|uniprotkb:Tripartite motif-containing protein 56(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384536|imex:IM-22301-1305 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112223.1|refseq:XP_011514891.1|ensembl:ENSG00000169871(gene)|ensembl:ENST00000306085(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|rcsb pdb:5JW7|reactome:R-HSA-3134975|uniprotkb:Q9BRZ2(identity)|human orfeome collection:13605(identity)|entrezgene/locuslink:81844(identity)|ddbj/embl/genbank:BC048194(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ezli6d8R3mc5aNovKvPv2ayypbE9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:14B4D67F5184E5E3|rigid:fl2FJ3QNx7kuTpFNaWC6lzxUJu8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE3-2 uniprotkb:Q13451 intact:EBI-9384556|ensembl:ENSP00000358073 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q9bte3-2(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384560|imex:IM-22301-1306 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-749378(isoform-parent)|uniprotkb:Q9BTE3-2(isoform-parent)|ensembl:ENSG00000197771(gene)|ensembl:ENST00000369077(transcript)|uniprotkb:Q9BTE3-2(identity)|human orfeome collection:5222(identity)|entrezgene/locuslink:79892(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:nJOq6jis1maK+M/X0TcR44HlxRw9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:1D56B61703740545|rigid:sfcJxeNqzwKYJe//9VnH1H8NdXg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9BTE6-2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384579|imex:IM-22301-1307 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:58402336AF6AFA94|rigid:sk9zsjy/Re8emGWxRckzyXK3SzA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9BTE6-2 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384601|imex:IM-22301-1308 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:8B11FC2EAE9248F5|rigid:BAFA98uWBBVsVjqK6cFv7Feo/Go false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9BTE6-2 intact:EBI-9356686 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q96be0_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384623|imex:IM-22301-1309 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:D5EFE24A16C4A363|rigid:4sg692vg5NMpE3JYitrLtjCvmWQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9BV07 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9384648 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q9bv07_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384645|imex:IM-22301-1310 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR039027|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0043491"(protein kinase B signaling)|uniprotkb:Q9BV07(identity)|ddbj/embl/genbank:BC000479(identity)|entrezgene/locuslink:207(identity)|human orfeome collection:5348(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:JMMv9P1oiFk1O6yB8p4Ibtmc1cI9606 intact-crc:81089469787E48C4|rigid:0lIP0eWCxfDr0P8JziTeCfxterw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BVE2 uniprotkb:P07900 intact:EBI-9384671|ensembl:ENSP00000480835 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:q9bve2_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384690|imex:IM-22301-1312 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003709.3|refseq:NP_112557.2|ensembl:ENSG00000065883(gene)|ensembl:ENST00000613626(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|uniprotkb:Q9BVE2(identity)|entrezgene/locuslink:8621(identity)|ddbj/embl/genbank:BC001274(identity)|human orfeome collection:8694(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:xLk7/Lq3uAsZq53et8dQUAyZMJ89606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:DB88F72C5B2E6FFD|rigid:TKGDfApaxwCLWBaV0ER8n4sm1Hg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BVE2 uniprotkb:Q13451 intact:EBI-9384671|ensembl:ENSP00000480835 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:q9bve2_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384668|imex:IM-22301-1311 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003709.3|refseq:NP_112557.2|ensembl:ENSG00000065883(gene)|ensembl:ENST00000613626(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|uniprotkb:Q9BVE2(identity)|entrezgene/locuslink:8621(identity)|ddbj/embl/genbank:BC001274(identity)|human orfeome collection:8694(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:xLk7/Lq3uAsZq53et8dQUAyZMJ89606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:DD02835AE4D2F185|rigid:uEQKT5RqL7qFI0U7Ud5seU5zt9Y false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9BVM2 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-749988|uniprotkb:Q8N5R1|uniprotkb:A8K289|uniprotkb:Q6QNL3|uniprotkb:Q9UFY6|ensembl:ENSP00000359170 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:dpcd_human(display_long)|uniprotkb:DPCD(gene name)|psi-mi:DPCD(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384711|imex:IM-22301-1313 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_056263.1|ensembl:ENSG00000166171(gene)|ensembl:ENST00000370151(transcript)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0060972"(left/right pattern formation)|interpro:IPR026224|go:"GO:0021678"(third ventricle development)|uniprotkb:Q9BVM2(identity)|entrezgene/locuslink:25911(identity)|ddbj/embl/genbank:BC001082(identity)|human orfeome collection:9371(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:k1AnQBTvPufE9zRF8lMAxFhGtug9606 intact-crc:4C876D66337B628C|rigid:E0J1+bbWGp6PFsqE80LeDXbEBD4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9BWF4 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9384731 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q9bwf4_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384735|imex:IM-22301-1314 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) interpro:IPR008045(MCM protein 2)|interpro:IPR031327|interpro:IPR001208(MCM)|interpro:IPR018525|interpro:IPR027417|interpro:IPR041562|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905775"(negative regulation of DNA helicase activity)|uniprotkb:Q9BWF4(identity)|ddbj/embl/genbank:BC007670(identity)|human orfeome collection:4536(identity)|entrezgene/locuslink:4171(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:kmiJv1bQieaYGIZzMiNic+jE7cc9606 intact-crc:ADEBDC82DFBD2EAA|rigid:l63XH3MWwIOUQfgsO397IS7PAGE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9BWF4 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-9384731 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:q9bwf4_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384757|imex:IM-22301-1315 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) interpro:IPR008045(MCM protein 2)|interpro:IPR031327|interpro:IPR001208(MCM)|interpro:IPR018525|interpro:IPR027417|interpro:IPR041562|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007049"(cell cycle)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905775"(negative regulation of DNA helicase activity)|uniprotkb:Q9BWF4(identity)|ddbj/embl/genbank:BC007670(identity)|human orfeome collection:4536(identity)|entrezgene/locuslink:4171(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:kmiJv1bQieaYGIZzMiNic+jE7cc9606 intact-crc:C842D9AC4299E183|rigid:wV8YOV9qhDm4rTJQWvDVVKiNa2E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXA6 uniprotkb:Q15773 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384779|imex:IM-22301-1316 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:14D63D2812D200F8|rigid:g+6QIWG8Ers13AFQ2NmC0pn9ars false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9BXA6 intact:EBI-9356629 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384801|imex:IM-22301-1317 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 intact-crc:5F617C3A263C7A80|rigid:s0GvHH8Y3PRV5WPQINOmwiyYMKA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9BXA6 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384823|imex:IM-22301-1318 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 intact-crc:31FB55848A36ECC1|rigid:L2j0UGx8sOby9/q8PrbtLuajp3Y false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q9BXA6 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384845|imex:IM-22301-1319 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 intact-crc:20D31175008C45DF|rigid:2FuAO0RCnINVRuvjY/AJD+nTJ4s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BXA6 uniprotkb:Q16543 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384866|imex:IM-22301-1320 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:C21A5C54C396D0FC|rigid:C4Ssu4v4vYGb/wA+Ruh4YZUfh8I false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9BXA6 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-851883|uniprotkb:Q6ZMC4|uniprotkb:Q96LJ4|uniprotkb:B2R9F8|ensembl:ENSP00000466056|ensembl:ENSP00000466477 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:tssk6_human(display_long)|uniprotkb:Serine/threonine-protein kinase SSTK(gene name synonym)|uniprotkb:Small serine/threonine kinase(gene name synonym)|uniprotkb:Cancer/testis antigen 72(gene name synonym)|uniprotkb:TSSK6(gene name)|psi-mi:TSSK6(display_short)|uniprotkb:SSTK(gene name synonym)|uniprotkb:FKSG82(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384886|imex:IM-22301-1321 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_114426.1|ensembl:ENSG00000178093(gene)|ensembl:ENST00000585580(transcript)|ensembl:ENST00000587522(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035092"(sperm DNA condensation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042710|uniprotkb:Q9BXA6(identity)|entrezgene/locuslink:83983(identity)|ddbj/embl/genbank:BC014611(identity)|human orfeome collection:1498(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:PN2FYOeqBrhCM2h+UMD2AzRSAUQ9606 intact-crc:4AA10CAEB7B4053E|rigid:O4xJfHbPwsRdRkQ5FZRlAHhoCAs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9BZG7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9384908 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q9bzg7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384911|imex:IM-22301-1322 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR001103(Androgen receptor)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0030521"(androgen receptor signaling pathway)|uniprotkb:Q9BZG7(identity)|ddbj/embl/genbank:BC132975(identity)|entrezgene/locuslink:367(identity)|human orfeome collection:70513(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Siw/0hCpEltVhtaS21LlTY5XeGM9606 intact-crc:E78D15822160F0C2|rigid:d8Aep0gXib7tz3M3zEfxdokPexM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BZG7 uniprotkb:Q53FC7 intact:EBI-9384908 intact:EBI-9356749 psi-mi:q9bzg7_human(display_long) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384932|imex:IM-22301-1323 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001103(Androgen receptor)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0030521"(androgen receptor signaling pathway)|uniprotkb:Q9BZG7(identity)|ddbj/embl/genbank:BC132975(identity)|entrezgene/locuslink:367(identity)|human orfeome collection:70513(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Siw/0hCpEltVhtaS21LlTY5XeGM9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:F731C0DB64E53A3C|rigid:Td+WvhnZF113D3HWnjyCwZFMpy4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9BZG7 intact:EBI-9356686 intact:EBI-9384908 psi-mi:q96be0_human(display_long) psi-mi:q9bzg7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384954|imex:IM-22301-1324 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR001103(Androgen receptor)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0030521"(androgen receptor signaling pathway)|uniprotkb:Q9BZG7(identity)|ddbj/embl/genbank:BC132975(identity)|entrezgene/locuslink:367(identity)|human orfeome collection:70513(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Siw/0hCpEltVhtaS21LlTY5XeGM9606 intact-crc:9571358884EB07C0|rigid:d6aZ1jfPy3leIqiJpEnqDOrDgCY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q9BZG7 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9384908 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q9bzg7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384976|imex:IM-22301-1325 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) interpro:IPR001103(Androgen receptor)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0030521"(androgen receptor signaling pathway)|uniprotkb:Q9BZG7(identity)|ddbj/embl/genbank:BC132975(identity)|entrezgene/locuslink:367(identity)|human orfeome collection:70513(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:Siw/0hCpEltVhtaS21LlTY5XeGM9606 intact-crc:971257D1E26FE967|rigid:tfE99itvfH3fqfL8nMIoUIxAL78 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BZI0 uniprotkb:Q9UKP3 intact:EBI-9384995 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 psi-mi:q9bzi0_human(display_long)|uniprotkb:RARG(gene name)|psi-mi:RARG(display_short) psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9384999|imex:IM-22301-1326 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR035500|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|uniprotkb:Q9BZI0(identity)|ddbj/embl/genbank:BC093729(identity)|human orfeome collection:71679(identity)|entrezgene/locuslink:5916(identity) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+OC9KIJfV0alBFFQTU+fzppvZdA9606 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 intact-crc:A4D5A734F56E49A8|rigid:uHmozB5aflXFR/7NRct3rf7NAGM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9C029 uniprotkb:Q03933 intact:EBI-2813981|uniprotkb:Q96J90|uniprotkb:Q96F67|uniprotkb:Q969F5|uniprotkb:Q96J89|uniprotkb:A2RUE4|uniprotkb:D3DWR7|ensembl:ENSP00000274773 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:trim7_human(display_long)|uniprotkb:TRIM7(gene name)|psi-mi:TRIM7(display_short)|uniprotkb:GNIP(gene name synonym)|uniprotkb:RNF90(gene name synonym)|uniprotkb:Glycogenin-interacting protein(gene name synonym)|uniprotkb:RING finger protein 90(gene name synonym)|uniprotkb:Tripartite motif-containing protein 7(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385018|imex:IM-22301-1327 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_203128.1|refseq:NP_976038.1|refseq:NP_976039.1|refseq:NP_976040.1|refseq:NP_976041.1|refseq:NP_976042.1|refseq:XP_016865392.1|refseq:XP_016865393.1|ensembl:ENSG00000146054(gene)|ensembl:ENST00000274773(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR043136|rcsb pdb:6UMA|rcsb pdb:6UMB|go:"GO:0005737"(cytoplasm)|uniprotkb:Q9C029(identity)|entrezgene/locuslink:81786(identity)|human orfeome collection:55039(identity)|ddbj/embl/genbank:BC132863(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ekxCiH+/bvn81rkv+308lZ2MMdA9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:4DBF46ACC1DAAAC2|rigid:kHQfk2SCC8rNBH94Q3CsJ8jiLdw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9C029 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-2813981|uniprotkb:Q96J90|uniprotkb:Q96F67|uniprotkb:Q969F5|uniprotkb:Q96J89|uniprotkb:A2RUE4|uniprotkb:D3DWR7|ensembl:ENSP00000274773 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:trim7_human(display_long)|uniprotkb:TRIM7(gene name)|psi-mi:TRIM7(display_short)|uniprotkb:GNIP(gene name synonym)|uniprotkb:RNF90(gene name synonym)|uniprotkb:Glycogenin-interacting protein(gene name synonym)|uniprotkb:RING finger protein 90(gene name synonym)|uniprotkb:Tripartite motif-containing protein 7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385037|imex:IM-22301-1328 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_203128.1|refseq:NP_976038.1|refseq:NP_976039.1|refseq:NP_976040.1|refseq:NP_976041.1|refseq:NP_976042.1|refseq:XP_016865392.1|refseq:XP_016865393.1|ensembl:ENSG00000146054(gene)|ensembl:ENST00000274773(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR043136|rcsb pdb:6UMA|rcsb pdb:6UMB|go:"GO:0005737"(cytoplasm)|uniprotkb:Q9C029(identity)|entrezgene/locuslink:81786(identity)|human orfeome collection:55039(identity)|ddbj/embl/genbank:BC132863(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:ekxCiH+/bvn81rkv+308lZ2MMdA9606 intact-crc:EDD3675A4939A982|rigid:tdQZhZ1x0isw6q0oICcwlKP3Ang false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9H0A0 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385059|imex:IM-22301-1329 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 intact-crc:285E8E59CAE6DC22|rigid:ZTJ85dMyCIO5U4SHyharKgJrnBU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9H0A0 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385080|imex:IM-22301-1330 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 intact-crc:D9E3D144E69D4E87|rigid:cm96scg5lXi2o7iYri6Z+v3KHGQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0A0 uniprotkb:O95816 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385099|imex:IM-22301-1331 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:34F6F740D7CC454F|rigid:Qettx1jIQPcfWSHsQ8OviX/CNT0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0A0 uniprotkb:Q8IVD9 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385121|imex:IM-22301-1332 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:5870EBB77E8FE012|rigid:A7UByjO5FZUtVvw/godRQt0jbfA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0A0 uniprotkb:B4DYC6 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 intact:EBI-9357028 psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385140|imex:IM-22301-1333 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:0A61ACCA129BE9EB|rigid:MhF/kMsV/xu+1qWU/UpDl9fPIAM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9H0A0 intact:EBI-9356686 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 psi-mi:q96be0_human(display_long) psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385160|imex:IM-22301-1334 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 intact-crc:B44F5B66350B66CE|rigid:xeyqU2erCmhzQDVeZd+kKkpX/M4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0A0 uniprotkb:Q9HB71 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385182|imex:IM-22301-1335 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:4537A1D9B0E75B6E|rigid:RJxP+IyESJETOcLfn9m0uAiU7Ow false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q9H0A0 intact:EBI-9356778 intact:EBI-876527|ensembl:ENSP00000257829|uniprotkb:B4DFD5|uniprotkb:E7ESU4|uniprotkb:E9PMN9|uniprotkb:Q86WK5|uniprotkb:Q9C0F4|uniprotkb:Q9HA61|uniprotkb:Q9NVF2 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:nat10_human(display_long)|uniprotkb:NAT10(gene name)|psi-mi:NAT10(display_short)|uniprotkb:KIAA1709(gene name synonym)|uniprotkb:ALP(gene name synonym)|uniprotkb:18S rRNA cytosine acetyltransferase(gene name synonym)|uniprotkb:N-acetyltransferase 10(gene name synonym)|uniprotkb:N-acetyltransferase-like protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385201|imex:IM-22301-1336 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) ensembl:ENSG00000135372(gene)|ensembl:ENST00000257829(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000154"(rRNA modification)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006473"(protein acetylation)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016020"(membrane)|go:"GO:0030496"(midbody)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051391"(tRNA acetylation)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0106162"(mRNA N-acetyltransferase activity)|go:"GO:1904812"(rRNA acetylation involved in maturation of SSU-rRNA)|go:"GO:1990883"(rRNA cytidine N-acetyltransferase activity)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR007807(Protein of unknown function DUF699, ATPase putative)|interpro:IPR013562(Region of unknown function DUF1726)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR027992|interpro:IPR032672|interpro:IPR033688|mint:Q9H0A0|rcsb pdb:6VLA|reactome:R-HSA-6790901|refseq:NP_001137502.1|refseq:NP_078938.2|uniprotkb:Q9H0A0(identity)|ddbj/embl/genbank:BC035558(identity)|human orfeome collection:9701(identity)|entrezgene/locuslink:55226(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:3eWpscghkRC8Km7mBsUQqjhCKVs9606 intact-crc:B02CE684590D0A8A|rigid:E2w83LppzWC2JP2n8hSPCKNkphk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9H4B7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385223|imex:IM-22301-1337 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:63A5EE3D6E398503|rigid:sgs3jlXTIPxAaQllmaSIuc3uD4M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9H4B7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385245|imex:IM-22301-1338 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:15CE5B3E898507D4|rigid:ZCNVH5QKG4qoBX4NPco5nFHkKs0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9H4B7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385266|imex:IM-22301-1339 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:4E97E03D22F49B82|rigid:w7GKl+9FkY6dbl4VoZgU7VCUb2U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9H4B7 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385288|imex:IM-22301-1340 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:0B5981555FF6A12B|rigid:UWSjw4guOHBg1W72cGYr+eg/8i4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9H4B7 intact:EBI-9356686 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:q96be0_human(display_long) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385310|imex:IM-22301-1341 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:9779CAD8D4AC183F|rigid:2XNV/IUBXTV1SWlZkbFIzYLiqYg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H4B7 uniprotkb:Q16543 intact:EBI-2949748|ensembl:ENSP00000217133 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385332|imex:IM-22301-1342 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:1F32D0DF7D0EFFDC|rigid:JYjeHE/mksycb+Ka5lh6d18oY5U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9H4B7 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-2949748|ensembl:ENSP00000217133 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:tbb1_human(display_long)|uniprotkb:TUBB1(gene name)|psi-mi:TUBB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385352|imex:IM-22301-1343 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000101162(gene)|ensembl:ENST00000217133(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0051225"(spindle assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9H4B7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-983189|reactome:R-HSA-9668328|refseq:NP_110400.1|dip:DIP-42487N|uniprotkb:Q9H4B7(identity)|ddbj/embl/genbank:BC033679(identity)|entrezgene/locuslink:81027(identity)|human orfeome collection:9833(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:6bCGUsGUoUdlvvDkLH2G+2V3cdc9606 intact-crc:BA9A4DEA03CEBFA9|rigid:3ZUU2V9wHJidoeSLXMAJsq1l6X8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9H4M8 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9385377 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q9h4m8_human(display_long)|uniprotkb:NR1I2(gene name)|psi-mi:NR1I2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385374|imex:IM-22301-1344 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) uniprotkb:Q9H4M8(identity)|ddbj/embl/genbank:BC017304(identity)|human orfeome collection:7814(identity)|entrezgene/locuslink:8856(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:0K6fY3KV5qVJvajyziKkvYksojQ9606 intact-crc:120DDFBBF536CEE1|rigid:/TK/+vqCBc1OZjv4WRNybT+H0Ek false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9H4M8 intact:EBI-9356629 intact:EBI-9385377 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q9h4m8_human(display_long)|uniprotkb:NR1I2(gene name)|psi-mi:NR1I2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385399|imex:IM-22301-1345 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) uniprotkb:Q9H4M8(identity)|ddbj/embl/genbank:BC017304(identity)|human orfeome collection:7814(identity)|entrezgene/locuslink:8856(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:0K6fY3KV5qVJvajyziKkvYksojQ9606 intact-crc:08B19DE33A99CD18|rigid:C10zsEjB48G3E15f5FpabFRIjJM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H611 uniprotkb:Q03933 intact:EBI-9385421|uniprotkb:Q33E24|uniprotkb:Q330H5|uniprotkb:Q1W5B6|uniprotkb:B2RPL7|ensembl:ENSP00000268043|ensembl:ENSP00000452792 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:pif1_human(display_long)|uniprotkb:PIF1(gene name)|psi-mi:PIF1(display_short)|uniprotkb:C15orf20(gene name synonym)|uniprotkb:DNA repair and recombination helicase PIF1(gene name synonym)|uniprotkb:PIF1/RRM3 DNA helicase-like protein(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385429|imex:IM-22301-1346 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520385.1|refseq:XP_011520386.1|refseq:NP_001273425.1|refseq:NP_001273426.1|refseq:NP_001273428.1|refseq:NP_079325.2|ensembl:ENSG00000140451(gene)|ensembl:ENST00000268043(transcript)|ensembl:ENST00000559239(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005739"(mitochondrion)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033678"(5'-3' DNA/RNA helicase activity)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003840(DNA helicase, Herpesviridae)|interpro:IPR010285(Protein of unknown function DUF889, eukaryote)|interpro:IPR027417|rcsb pdb:5FHH|rcsb pdb:6HPH|rcsb pdb:6HPQ|rcsb pdb:6HPT|rcsb pdb:6HPU|reactome:R-HSA-171319|go:"GO:0005524"(ATP binding)|uniprotkb:Q9H611(identity)|entrezgene/locuslink:80119(identity)|ddbj/embl/genbank:BC137504(identity)|human orfeome collection:70711(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:MbqM6HbahLbQ6CuZ1IEjsAm1pzo9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:008183685E7BC6D5|rigid:EEYkdFnV9ZvTPHEDiqsCkh6UMZQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6G9 uniprotkb:Q9BTE6-2 intact:EBI-9385448 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q9h6g9_human(display_long) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385451|imex:IM-22301-1347 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9H6G9(identity)|entrezgene/locuslink:56987(identity)|human orfeome collection:56840(identity)|ddbj/embl/genbank:BC131718(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Shfn6LMy2dGX23Ij578T0habjGU9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:1B107C83E8BE3588|rigid:cpipu6K57LIlacSyuxqwj2GC4OA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:Q6PK50 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-9356629 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385473|imex:IM-22301-1348 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:9272966D77B510E1|rigid:9Pp6eLlC7jt9+X9BIt+Wup/lOdM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:Q9UHV9 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385495|imex:IM-22301-1349 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:5CE83BA45BD798E6|rigid:8ufVN7HhEzpqS/dINjnB4o3Llr8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:P07900 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385515|imex:IM-22301-1350 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:463C6F00799A72C2|rigid:bzYzYwxylniMKC79Q1emVuUNmh0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:Q99471 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385536|imex:IM-22301-1351 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:1EDAB4F54447969B|rigid:itDnLPVib+udlU7KMhEMqjT0f84 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:Q9H6T3 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385555|imex:IM-22301-1352 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 intact-crc:0E9AD76AB5235A8B|rigid:jGjLoE7UOeTM+z2XVDaw2jsVO2I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6Y2 uniprotkb:Q15773 intact:EBI-5280144|uniprotkb:Q9NXK4|ensembl:ENSP00000351100 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:wdr55_human(display_long)|uniprotkb:WDR55(gene name)|psi-mi:WDR55(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385577|imex:IM-22301-1353 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060176.2|refseq:XP_005268526.1|interpro:IPR017422(WD repeat protein 55)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|mint:Q9H6Y2|rcsb pdb:7KQQ|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|ensembl:ENSG00000120314(gene)|ensembl:ENST00000358337(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|uniprotkb:Q9H6Y2(identity)|human orfeome collection:71279(identity)|ddbj/embl/genbank:BC068485(identity)|entrezgene/locuslink:54853(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:bAd2buaMSAqVqEt4vIB11NSh+z09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:E840B2C27025E7C7|rigid://UOoHGmfsnePygZxFNIi8vHIJg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9H700 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9385599 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q9h700_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385602|imex:IM-22301-1354 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) uniprotkb:Q9H700(identity)|entrezgene/locuslink:26098(identity)|human orfeome collection:56089(identity)|ddbj/embl/genbank:BC107479(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:VXmMhcHi4gPm7NaZldRtHjaDhDg9606 intact-crc:5BB617DE53600CEA|rigid:lf4pcpuK0TW4OAhLOCBAi0j7KpQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H9A6 uniprotkb:B4DYC6 intact:EBI-1043135|uniprotkb:Q9NXC1|uniprotkb:Q9BTR7|uniprotkb:Q9NSK1|ensembl:ENSP00000359990 intact:EBI-9357028 psi-mi:lrc40_human(display_long)|uniprotkb:LRRC40(gene name)|psi-mi:LRRC40(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385623|imex:IM-22301-1355 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000066557(gene)|ensembl:ENST00000370952(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_060238.3|uniprotkb:Q9H9A6(identity)|ddbj/embl/genbank:BC008586(identity)|entrezgene/locuslink:55631(identity)|human orfeome collection:319(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:DxDqTX9DvC1eU/vjACu8pZLo+Qk9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:CBCFE036C51C20F1|rigid:4gv2w+WBUtEc5FdOLJBBOTnH+FM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q9H9C5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9385646 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q9h9c5_human(display_long)|uniprotkb:DUB1(gene name)|psi-mi:DUB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385643|imex:IM-22301-1356 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|uniprotkb:Q9H9C5(identity)|entrezgene/locuslink:57602(identity)|ddbj/embl/genbank:BC038983(identity)|human orfeome collection:10284(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:9X2qRncb7hsqV8fhs2tEFODqrEQ9606 intact-crc:53A3902C94520398|rigid:BKs/Y53pF7c+EXJXFbw0SlK7i3M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9H9C5 intact:EBI-9356629 intact:EBI-9385646 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q9h9c5_human(display_long)|uniprotkb:DUB1(gene name)|psi-mi:DUB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385666|imex:IM-22301-1357 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|uniprotkb:Q9H9C5(identity)|entrezgene/locuslink:57602(identity)|ddbj/embl/genbank:BC038983(identity)|human orfeome collection:10284(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:9X2qRncb7hsqV8fhs2tEFODqrEQ9606 intact-crc:DB437173E6AEAA7B|rigid:I176UClLMUGaJ2vxehKlVgsKg2U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H9C5 uniprotkb:Q9BTE6-2 intact:EBI-9385646 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q9h9c5_human(display_long)|uniprotkb:DUB1(gene name)|psi-mi:DUB1(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385688|imex:IM-22301-1358 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|uniprotkb:Q9H9C5(identity)|entrezgene/locuslink:57602(identity)|ddbj/embl/genbank:BC038983(identity)|human orfeome collection:10284(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9X2qRncb7hsqV8fhs2tEFODqrEQ9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:08799256A0B1F60D|rigid:FFH0kdfbPO/7ijlSLL/UaMqNCC4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV0 uniprotkb:Q9Y266 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385710|imex:IM-22301-1359 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1|uniprotkb:Q9HAV0(identity)|ddbj/embl/genbank:BC000873(identity)|human orfeome collection:2749(identity)|entrezgene/locuslink:59345(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:905C66AD37F17298|rigid:88m9NgpBNwRM3IA+STt4g8IkQQs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV0 uniprotkb:Q9HAV2 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 intact:EBI-9357141 psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385729|imex:IM-22301-1360 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1|uniprotkb:Q9HAV0(identity)|ddbj/embl/genbank:BC000873(identity)|human orfeome collection:2749(identity)|entrezgene/locuslink:59345(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:507CB8C69949A081|rigid:/qA4mDReV3q9KHDl1W9GFDRHFes false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9HAV0 intact:EBI-9356686 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 psi-mi:q96be0_human(display_long) psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385751|imex:IM-22301-1361 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1|uniprotkb:Q9HAV0(identity)|ddbj/embl/genbank:BC000873(identity)|human orfeome collection:2749(identity)|entrezgene/locuslink:59345(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 intact-crc:75306B87727E67D9|rigid:s204A3E2y7EmzhhMSiX+jjb61iI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q9HAV0 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385773|imex:IM-22301-1362 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1|uniprotkb:Q9HAV0(identity)|ddbj/embl/genbank:BC000873(identity)|human orfeome collection:2749(identity)|entrezgene/locuslink:59345(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 intact-crc:7087BA875A0BA20A|rigid:561Jst0liuZqGM1nN5EhjxLzChY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV0 uniprotkb:Q99471 intact:EBI-358539|uniprotkb:B3KMH5|uniprotkb:D3DNR8|ensembl:ENSP00000501882|ensembl:ENSP00000502628|ensembl:ENSP00000232564 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:gbb4_human(display_long)|uniprotkb:GNB4(gene name)|psi-mi:GNB4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385792|imex:IM-22301-1363 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067642.1|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|reactome:R-HSA-456926|ensembl:ENSG00000114450(gene)|ensembl:ENST00000232564(transcript)|ensembl:ENST00000674862(transcript)|ensembl:ENST00000676128(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0021762"(substantia nigra development)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9HAV0|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|refseq:XP_006713784.1|refseq:XP_005247749.1|uniprotkb:Q9HAV0(identity)|ddbj/embl/genbank:BC000873(identity)|human orfeome collection:2749(identity)|entrezgene/locuslink:59345(identity) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:L6hFuZe1Luk8YTFW+posXDa2Qj49606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:92FA4C70239BE7D6|rigid:tyXGIqa40fCsYZhF6RdeiAtXp5s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q53FC7 intact:EBI-9357141 intact:EBI-9356749 psi-mi:q9hav2_human(display_long) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385811|imex:IM-22301-1364 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:BD2CABE846AA32D5|rigid:WvJu5BIqr8rWFU2TBIS2Pfdk1aA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q03933 intact:EBI-9357141 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:q9hav2_human(display_long) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385833|imex:IM-22301-1365 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:74B7693BEDF9A46F|rigid:6+ZeP+rh0Rn+yAGGSo0oUkfEUqA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q9HAV2 intact:EBI-9357141 intact:EBI-9357141 psi-mi:q9hav2_human(display_long) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385852|imex:IM-22301-1366 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:2CBD9EF7105733EF|rigid:w1aD3uzqSi8FTPqCjNY+pRPgQUA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HAV2 uniprotkb:Q96BE0 intact:EBI-9357141 intact:EBI-9356686 psi-mi:q9hav2_human(display_long) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385874|imex:IM-22301-1367 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:55A90D7E82AD2B6B|rigid:p1VkG9daOFn1CBuWrvSb8k3myhQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HCU5 uniprotkb:Q6PK50 intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8 intact:EBI-9356629 psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385896|imex:IM-22301-1368 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1|uniprotkb:Q9HCU5(identity)|human orfeome collection:2887(identity)|entrezgene/locuslink:10113(identity)|ddbj/embl/genbank:BC002765(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:E2F884AAA5CFA837|rigid:n7U8rS7QyQeSG7GtKC1xLw1r5Xc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HCU5 uniprotkb:Q9Y266 intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385918|imex:IM-22301-1369 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1|uniprotkb:Q9HCU5(identity)|human orfeome collection:2887(identity)|entrezgene/locuslink:10113(identity)|ddbj/embl/genbank:BC002765(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:4E404DCE54F20464|rigid:mB0K/aY+m/M0cOX3VEYD/w/5MH8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9NPI8 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-81589|ensembl:ENSP00000330875|uniprotkb:Q52LM0 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:fancf_human(display_long)|uniprotkb:FANCF(gene name)|psi-mi:FANCF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385937|imex:IM-22301-1370 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity)|uniprotkb:Q8K2C9(identity) ensembl:ENSG00000183161(gene)|ensembl:ENST00000327470(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR035428|interpro:IPR038505|mint:Q9NPI8|rcsb pdb:2IQC|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|refseq:NP_073562.1|uniprotkb:Q9NPI8(identity)|entrezgene/locuslink:2188(identity)|ddbj/embl/genbank:BC063038(identity)|human orfeome collection:55485(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Muoiy5Y/g3FEdtc9Bp9JLmm7dFo9606 intact-crc:F386C1A3E5C111FC|rigid:Q6it6VkbrHYKW5ORq2tksVYvVjU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPV4 uniprotkb:Q8IVD9 intact:EBI-9385983 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:q9npv4_human(display_long)|uniprotkb:DKFZp762F2011(gene name)|psi-mi:DKFZp762F2011(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385980|imex:IM-22301-1372 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|uniprotkb:Q9NPV4(identity)|ddbj/embl/genbank:BC042040(identity)|entrezgene/locuslink:56919(identity)|human orfeome collection:11352(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:gS7yDB77KHb+iWKk7Wy2Sfti9d09606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:35614415F18D61B0|rigid:ijHQ5JWcdY1ZFBxNNUYHr3Eu8fI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI8 uniprotkb:Q9BPW0 intact:EBI-81589|ensembl:ENSP00000330875|uniprotkb:Q52LM0 intact:EBI-9356778 psi-mi:fancf_human(display_long)|uniprotkb:FANCF(gene name)|psi-mi:FANCF(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9385958|imex:IM-22301-1371 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183161(gene)|ensembl:ENST00000327470(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043240"(Fanconi anaemia nuclear complex)|interpro:IPR035428|interpro:IPR038505|mint:Q9NPI8|rcsb pdb:2IQC|rcsb pdb:7KZP|rcsb pdb:7KZQ|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|refseq:NP_073562.1|uniprotkb:Q9NPI8(identity)|entrezgene/locuslink:2188(identity)|ddbj/embl/genbank:BC063038(identity)|human orfeome collection:55485(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Muoiy5Y/g3FEdtc9Bp9JLmm7dFo9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:20C0466883D6B748|rigid:u4DsN/5difIv9UjzUC4iJVWD4GQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9NPV4 intact:EBI-9357028 intact:EBI-9385983 psi-mi:b4dyc6_human(display_long) psi-mi:q9npv4_human(display_long)|uniprotkb:DKFZp762F2011(gene name)|psi-mi:DKFZp762F2011(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386003|imex:IM-22301-1373 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|uniprotkb:Q9NPV4(identity)|ddbj/embl/genbank:BC042040(identity)|entrezgene/locuslink:56919(identity)|human orfeome collection:11352(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:gS7yDB77KHb+iWKk7Wy2Sfti9d09606 intact-crc:EA3CE28D5AEBB063|rigid:IeTwPm1w4gmvfe/2RTqGMc1DpHY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9NPV4 intact:EBI-9356686 intact:EBI-9385983 psi-mi:q96be0_human(display_long) psi-mi:q9npv4_human(display_long)|uniprotkb:DKFZp762F2011(gene name)|psi-mi:DKFZp762F2011(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386023|imex:IM-22301-1374 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR027417|go:"GO:0004386"(helicase activity)|uniprotkb:Q9NPV4(identity)|ddbj/embl/genbank:BC042040(identity)|entrezgene/locuslink:56919(identity)|human orfeome collection:11352(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:gS7yDB77KHb+iWKk7Wy2Sfti9d09606 intact-crc:6B55C295538A28C6|rigid:S3Sz5AbZ8+H6OAUjj7ZR/hTgpEA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9NQR3 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-9386048 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:q9nqr3_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386045|imex:IM-22301-1375 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) uniprotkb:Q9NQR3(identity)|ddbj/embl/genbank:BC115037(identity)|entrezgene/locuslink:672(identity)|human orfeome collection:55703(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:WUcA+d0/FX6m+bTSUw39viiZRfw9606 intact-crc:CB720D85BCAC2E46|rigid:aM/xsj9ZlKlLR7EsRouMSTg1kmg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQR3 uniprotkb:Q96BE0 intact:EBI-9386048 intact:EBI-9356686 psi-mi:q9nqr3_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386071|imex:IM-22301-1376 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9NQR3(identity)|ddbj/embl/genbank:BC115037(identity)|entrezgene/locuslink:672(identity)|human orfeome collection:55703(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WUcA+d0/FX6m+bTSUw39viiZRfw9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:AA256DF31A5C4874|rigid:7JJozK0RMg+J0ZHv/3L6ymi99Ok false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQR3 uniprotkb:Q9BTE6-2 intact:EBI-9386048 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:q9nqr3_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386093|imex:IM-22301-1377 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9NQR3(identity)|ddbj/embl/genbank:BC115037(identity)|entrezgene/locuslink:672(identity)|human orfeome collection:55703(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WUcA+d0/FX6m+bTSUw39viiZRfw9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:CDBABED906268BEE|rigid:x4ZglDIh7bwT8km+CXzxLe4/i7I false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q9NR20 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-3914009|uniprotkb:A8K8F7|uniprotkb:Q92631|uniprotkb:Q8NEF2|ensembl:ENSP00000010132|ensembl:ENSP00000441755 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:dyrk4_human(display_long)|uniprotkb:DYRK4(gene name)|psi-mi:DYRK4(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386115|imex:IM-22301-1378 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_003836.1|ensembl:ENSG00000010219(gene)|ensembl:ENST00000010132(transcript)|ensembl:ENST00000540757(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042521|uniprotkb:Q9NR20(identity)|entrezgene/locuslink:8798(identity)|ddbj/embl/genbank:BC031244(identity)|human orfeome collection:2212(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:xfWtQZ5JGk38qm2cfJuF/SZNrb09606 intact-crc:41AB1966E76A79E8|rigid:UqNiA1Lc0Rn7Rskh+IgLqml32wE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q13451 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386136|imex:IM-22301-1379 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:035274CDD1FE737D|rigid:YSs6YXyO1A3nZ5XLtomoTe+H/Sc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q8IVD9 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386177|imex:IM-22301-1381 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:F09272789103C662|rigid:UA0q8H3uSmNug2aDFaNXkBlKGbM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q6PK50 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-9356629 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386155|imex:IM-22301-1380 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:12CA1D603DB07FF9|rigid:Uid6Xz1g+owCftD5HDsCbSOpiLM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q96BE0 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-9356686 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386216|imex:IM-22301-1383 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:C5C1AFC7E3C7D30F|rigid:MHly44AlFVqX8zXVkR9H+umUA8Q false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:B4DYC6 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-9357028 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386196|imex:IM-22301-1382 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:038135EE1EB87EAA|rigid:726+U83h9kefDAw5qTz/GYn73eA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:P07900 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386238|imex:IM-22301-1384 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:6E29D400289B2B8A|rigid:4T2ZmsUZRM0JVY4nHQ0TmFj1A+c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q9HB71 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386259|imex:IM-22301-1385 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460(identity)|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:469BCED3B7F0B825|rigid:3Ivj0l62ogGbX1nPqzq5FXHNT/c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NRW8 uniprotkb:Q96BE0 intact:EBI-9386278 intact:EBI-9356686 psi-mi:q9nrw8_human(display_long)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386282|imex:IM-22301-1386 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q9NRW8(identity)|human orfeome collection:3697(identity)|entrezgene/locuslink:4771(identity)|ddbj/embl/genbank:BC003112(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Grq+EqVn+hQyX56iHtBxAmBaCx49606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:85A9A498F0C99580|rigid:OXMKyw0rbI8Kh62xNdgDKb9d/js false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q9NUG6 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-307050|uniprotkb:Q96GP3|uniprotkb:Q9BUW8|ensembl:ENSP00000202017|uniprotkb:B2R511 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:pdrg1_human(display_long)|uniprotkb:PDRG1(gene name)|psi-mi:PDRG1(display_short)|uniprotkb:C20orf126(gene name synonym)|uniprotkb:PDRG(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386304|imex:IM-22301-1387 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) ensembl:ENSG00000088356(gene)|ensembl:ENST00000202017(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR030482|mint:Q9NUG6|refseq:NP_110442.1|dip:DIP-27568N|uniprotkb:Q9NUG6(identity)|entrezgene/locuslink:81572(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:Q6qLyEyyEFBqxYhfx2lYg05nixQ9606 intact-crc:E294C295B1562013|rigid:tSl7ara5Q1X9vU+01GQRKcHlFtg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NUG6 uniprotkb:Q9UHV9 intact:EBI-307050|uniprotkb:Q96GP3|uniprotkb:Q9BUW8|ensembl:ENSP00000202017|uniprotkb:B2R511 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:pdrg1_human(display_long)|uniprotkb:PDRG1(gene name)|psi-mi:PDRG1(display_short)|uniprotkb:C20orf126(gene name synonym)|uniprotkb:PDRG(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386321|imex:IM-22301-1388 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088356(gene)|ensembl:ENST00000202017(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR030482|mint:Q9NUG6|refseq:NP_110442.1|dip:DIP-27568N|uniprotkb:Q9NUG6(identity)|entrezgene/locuslink:81572(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Q6qLyEyyEFBqxYhfx2lYg05nixQ9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:EC52C2550DABBC2B|rigid:GIUWRzmjjpXNROWRFJ+HEfLqHKU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9NW71 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9386339 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:q9nw71_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386342|imex:IM-22301-1389 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q9NW71(identity)|human orfeome collection:12217(identity)|entrezgene/locuslink:90293(identity)|ddbj/embl/genbank:BC064576(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:/vrUcOj/o9c8HfngRHiib0fsbGA9606 intact-crc:349E00649706D16D|rigid:hgFE7vuPPCwOBWLpBosHQedLx9U false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9NWG3 intact:EBI-9356629 intact:EBI-9378605 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:q9nwg3_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386361|imex:IM-22301-1390 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) uniprotkb:Q9NWG3(identity)|human orfeome collection:11189(identity)|ddbj/embl/genbank:BC037992(identity)|entrezgene/locuslink:55898(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:pUVn+gV06Z0QldIs4vrzAcRZzvk9606 intact-crc:79B4DF828A7987FC|rigid:5QxOoPG/SlvqDq/xA8Ej6BNDVjo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYK1 uniprotkb:P58340 intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386383|imex:IM-22301-1391 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|uniprotkb:Q9NYK1(identity)|human orfeome collection:10091(identity)|entrezgene/locuslink:51284(identity)|ddbj/embl/genbank:BC033651(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:173205ED7B84D7CE|rigid:NoxwM2Et6H3OCzBEZOwlrTxi6Lk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9NYK1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386405|imex:IM-22301-1392 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|uniprotkb:Q9NYK1(identity)|human orfeome collection:10091(identity)|entrezgene/locuslink:51284(identity)|ddbj/embl/genbank:BC033651(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606 intact-crc:913B9B115AB5DD3C|rigid:gbovWTmg8zQAgseMG+bstB9jaGs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9NYK1 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386426|imex:IM-22301-1393 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|uniprotkb:Q9NYK1(identity)|human orfeome collection:10091(identity)|entrezgene/locuslink:51284(identity)|ddbj/embl/genbank:BC033651(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606 intact-crc:91538D386F232A76|rigid:i/kkKmDgTSlQMR2oi2rcqJzvUR8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYK1 uniprotkb:Q13200 intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386448|imex:IM-22301-1394 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|uniprotkb:Q9NYK1(identity)|human orfeome collection:10091(identity)|entrezgene/locuslink:51284(identity)|ddbj/embl/genbank:BC033651(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:D24F05CB2D7273BF|rigid:RqCLWG/Cy/u5Pet5UtiOKaU0UpY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYK1 uniprotkb:Q9BTE6-2 intact:EBI-2844259|uniprotkb:Q9NR98|uniprotkb:D1CS69|ensembl:ENSP00000370034 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:tlr7_human(display_long)|uniprotkb:TLR7(gene name)|psi-mi:TLR7(display_short)|uniprotkb:UNQ248/PRO285(orf name) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386470|imex:IM-22301-1395 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057646.1|ensembl:ENSG00000196664(gene)|ensembl:ENST00000380659(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR026906|interpro:IPR032675|interpro:IPR035897|rcsb pdb:7CYN|reactome:R-HSA-1679131|reactome:R-HSA-168181|reactome:R-HSA-9679191|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975155|uniprotkb:Q9NYK1(identity)|human orfeome collection:10091(identity)|entrezgene/locuslink:51284(identity)|ddbj/embl/genbank:BC033651(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Rp6Y8SSxXYZiOoSIPB3VWhWPlP49606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:F312C44497CFDD68|rigid:/fa0wd8SxsJ6M2rSEBE4985OBKE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q9NYS7 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386492|imex:IM-22301-1396 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:8FC299DB14A6AEFD|rigid:BkZuK9MlNunQuYgyq6wqEkwErYw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9NYS7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386511|imex:IM-22301-1397 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:2F5B05CECD3D8702|rigid:hx66bRpN6iLdg1PoRar+B4PtdII false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:Q6PK50 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-9356629 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386532|imex:IM-22301-1398 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:8058BF9509321E7F|rigid:RpkLOeOGlYkj8fQP1Ixi9vzOALs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:Q9NYS7 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386554|imex:IM-22301-1399 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:9D84356F17EE21F9|rigid:I7f+3ZVJAiQKRcboq5Egu/HkZZM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:Q9Y266 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386573|imex:IM-22301-1400 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:CA100523919C5E5E|rigid:xlzpj9FeHINKdUby4+NAn2t6Sqc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHV9 uniprotkb:Q9NYS7 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386592|imex:IM-22301-1401 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:D7FF4BB99FDA7D21|rigid:0KrgP6NbyegkKDKTRWLYnkVcD4w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:B4DYC6 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-9357028 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386631|imex:IM-22301-1403 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:00923D75FFEC7F3F|rigid:oBYdtQHfKBOJ8EqBEhhv9wr6wJ4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9NYS7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386612|imex:IM-22301-1402 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:4DFCE06C4484F069|rigid:W+LoqRqorTUoa8ImnDE1eeY6Orc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3UJD6-1 uniprotkb:Q9NYS7 intact:EBI-9361730|ensembl:ENSMUSP00000006854 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386673|imex:IM-22301-1405 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:E56B0C16E2D05E09|rigid:eMjk20giE/uU2/HCrar6v7Iy/Zc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:Q9NYS7 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386651|imex:IM-22301-1404 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:9E030375921B5104|rigid:QCTWnDUXZY0d2Y/GxncYLeCepwE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:Q96BE0 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-9356686 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386694|imex:IM-22301-1406 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:57530D32D745B289|rigid:dcdboUtqG01KX47pDaSd8DFAw0k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:P31948 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386716|imex:IM-22301-1407 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:2F58DDA1552EE693|rigid:6f+0OIZX25Sna7gX0KcvWgj+e1o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:Q9UIM3 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386735|imex:IM-22301-1408 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:996CC39B7DD30662|rigid:Iaz40ZZtVeuKlTZ1pxyznEDlFbI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NYS7 uniprotkb:Q9HB71 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386754|imex:IM-22301-1409 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:66D2EDAD9857233C|rigid:phJe0VxndAf5iwuQiDb6sn67Mlc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q9NYS7 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386773|imex:IM-22301-1410 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:75B7BC0BBCC279E5|rigid:xPSt1KjYILRNQ6/mpmbDdIeNsV8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q9NYS7 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386792|imex:IM-22301-1411 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:E6F8F66E7734BF94|rigid:B6t14z0JeCUtrGpMDwAp6LkdnBU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9NYS7 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386811|imex:IM-22301-1412 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:0335D2602EB51DBE|rigid:MXg/Gk0hI9wRatvT4v9cRKfH6oM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q9NYS7 intact:EBI-9356778 intact:EBI-719743|uniprotkb:Q9NRX9|ensembl:ENSP00000319474|uniprotkb:B4DIE6|uniprotkb:B4DPV6 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:wsb2_human(display_long)|uniprotkb:CS box-containing WD protein(gene name synonym)|uniprotkb:WSB2(gene name)|psi-mi:WSB2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386833|imex:IM-22301-1413 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_061109.1|ensembl:ENSG00000176871(gene)|ensembl:ENST00000315436(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR001496(SOCS protein, C-terminal)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036036|interpro:IPR036322|reactome:R-HSA-8951664|refseq:NP_001265486.1|refseq:NP_001265487.1|refseq:XP_016875131.1|uniprotkb:Q9NYS7(identity)|human orfeome collection:247(identity)|entrezgene/locuslink:55884(identity)|ddbj/embl/genbank:BC015887(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:pIH/2va9FT6DPwDfVMGrnnQgs0o9606 intact-crc:2D88E910CE8D5F5F|rigid:A3kOPoDUp5UtX7Sple8qTRE0YBY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9P0M6 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-3922608|uniprotkb:Q5SQT2|ensembl:ENSP00000503835|ensembl:ENSP00000362352 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:h2aw_human(display_long)|uniprotkb:MACROH2A2(gene name)|psi-mi:MACROH2A2(display_short)|uniprotkb:H2AFY2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386855|imex:IM-22301-1414 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) dip:DIP-48563N|refseq:NP_061119.1|ensembl:ENSG00000099284(gene)|ensembl:ENST00000373255(transcript)|ensembl:ENST00000679349(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001740"(Barr body)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0007420"(brain development)|go:"GO:0007549"(dosage compensation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR002119(Histone H2A)|interpro:IPR002589(Appr-1-p processing)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR021171|interpro:IPR032454|interpro:IPR035796|interpro:IPR043472|rcsb pdb:2XD7|rcsb pdb:6FY5|uniprotkb:Q9P0M6(identity)|entrezgene/locuslink:55506(identity)|ddbj/embl/genbank:BC016172(identity)|human orfeome collection:235(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:xOLJc5I2oZLPBDLrA5IT2lYBQFM9606 intact-crc:097A1FA0532EDFF9|rigid:hidv/ndpWubGP5hcWKV71H1R4YU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95801 uniprotkb:Q9P0T5 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-9386878 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:q9p0t5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386875|imex:IM-22301-1415 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity) interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR039717|uniprotkb:Q9P0T5(identity)|entrezgene/locuslink:51236(identity)|human orfeome collection:3845(identity)|ddbj/embl/genbank:BC003035(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:tBp/VGk919y7VsXelCHu+p3rgDk9606 intact-crc:BDB5B673A2E5BE7D|rigid:VZtSRdStUfr+LlDethXbxnW6Rm0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:P58340 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386897|imex:IM-22301-1416 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:2F64B4AC9EC99DD8|rigid:XCWy6WePAA7oDDD3RaMzAXAc0AQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:Q15773 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386919|imex:IM-22301-1417 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:EAE62067BA38EE98|rigid:iQ9eFUVZh9N4Hkk+SZrVRqQWNgk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:Q6PK50 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-9356629 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386941|imex:IM-22301-1418 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:30141D59CCE411EB|rigid:NjQrtW2BaZpFhwYFXJLw2aIEP7M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q9P2K8 intact:EBI-9356749 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:q53fc7_human(display_long) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386963|imex:IM-22301-1419 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:BF0616F0C617EC7F|rigid:sNuDqFcNiZKW0WzotDAWjKrgdms false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95816 uniprotkb:Q9P2K8 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9386985|imex:IM-22301-1420 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:FE8453E7FF1CF8DF|rigid:JB+rc0TXxXylZFDaP+B9fdqJ+Bc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:Q8IVD9 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387007|imex:IM-22301-1421 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:249D5B7846033734|rigid:d0FDKrESpxNQPJvOOIB9bWjsQGo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:B4DYC6 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-9357028 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387026|imex:IM-22301-1422 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:AB995D3404AC2840|rigid:vn4vY48M4iQ6MG7YdPfUvd8pWu8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9P2K8 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387046|imex:IM-22301-1423 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:FF7D0FD2D37062ED|rigid:duDynKtQ3+Vt5TBm9etJbiaAoaE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:Q96BE0 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-9356686 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387068|imex:IM-22301-1424 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:E7FA570460546FA3|rigid:Z4k6Gl6Y+L6WbXWGs68RTEr33aU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:P31948 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387090|imex:IM-22301-1425 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:2075D37AA94265D1|rigid:pNSu4Pt4YWcypwUbWTbxaOsZyhI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9P2K8 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387109|imex:IM-22301-1426 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:80FB66955A91E18E|rigid:fmZQhC2pBSZl1Xlu3HoOu5XY2RI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q9P2K8 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387129|imex:IM-22301-1427 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:E088D3C91E97D9FB|rigid:547G3i510Vnlb885IyJVAbfe7H8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P2K8 uniprotkb:Q9BTE6-2 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387148|imex:IM-22301-1428 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012|uniprotkb:Q9P2K8(identity)|human orfeome collection:6823(identity)|entrezgene/locuslink:440275(identity)|ddbj/embl/genbank:BC009350(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:1774CB63086F4327|rigid:kEj573/gveI3V292aOOzjTdYeWY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q9UBK9 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-357355|ensembl:ENSP00000327797|uniprotkb:B2R561|uniprotkb:Q5JZG3|uniprotkb:Q9Y6E5|uniprotkb:A0A0C4DFR8 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:uxt_human(display_long)|uniprotkb:UXT(gene name)|psi-mi:UXT(display_short)|uniprotkb:HSPC024(orf name)|uniprotkb:Ubiquitously expressed transcript protein(gene name synonym)|uniprotkb:Androgen receptor trapped clone 27 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387170|imex:IM-22301-1429 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) ensembl:ENSG00000126756(gene)|ensembl:ENST00000333119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|interpro:IPR003994(Prefoldin related, ubiquitously expressed transcript)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:Q9UBK9|reactome:R-HSA-8953750|go:"GO:0003714"(transcription corepressor activity)|refseq:NP_004173.1|refseq:NP_705582.1|uniprotkb:Q9UBK9(identity)|entrezgene/locuslink:8409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:XhE14Q7CfwVXxJ4fTiRQTm3Idvk9606 intact-crc:5CCFA592BAA554B2|rigid:+wjDTImE5cOFMd67t7D1JIP8umA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H6T3 uniprotkb:Q9UBK9 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357355|ensembl:ENSP00000327797|uniprotkb:B2R561|uniprotkb:Q5JZG3|uniprotkb:Q9Y6E5|uniprotkb:A0A0C4DFR8 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:uxt_human(display_long)|uniprotkb:UXT(gene name)|psi-mi:UXT(display_short)|uniprotkb:HSPC024(orf name)|uniprotkb:Ubiquitously expressed transcript protein(gene name synonym)|uniprotkb:Androgen receptor trapped clone 27 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387187|imex:IM-22301-1430 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|entrezgene/locuslink:79657(identity)|ddbj/embl/genbank:BC056415(identity)|human orfeome collection:11967(identity) ensembl:ENSG00000126756(gene)|ensembl:ENST00000333119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|interpro:IPR003994(Prefoldin related, ubiquitously expressed transcript)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:Q9UBK9|reactome:R-HSA-8953750|go:"GO:0003714"(transcription corepressor activity)|refseq:NP_004173.1|refseq:NP_705582.1|uniprotkb:Q9UBK9(identity)|entrezgene/locuslink:8409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:XhE14Q7CfwVXxJ4fTiRQTm3Idvk9606 intact-crc:D44AFA5121986565|rigid:gm/mAk5LNpzLjuzLvXp7tFfH8FM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHV9 uniprotkb:Q9UBK9 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 intact:EBI-357355|ensembl:ENSP00000327797|uniprotkb:B2R561|uniprotkb:Q5JZG3|uniprotkb:Q9Y6E5|uniprotkb:A0A0C4DFR8 psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:uxt_human(display_long)|uniprotkb:UXT(gene name)|psi-mi:UXT(display_short)|uniprotkb:HSPC024(orf name)|uniprotkb:Ubiquitously expressed transcript protein(gene name synonym)|uniprotkb:Androgen receptor trapped clone 27 protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387207|imex:IM-22301-1431 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) ensembl:ENSG00000126756(gene)|ensembl:ENST00000333119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|interpro:IPR003994(Prefoldin related, ubiquitously expressed transcript)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:Q9UBK9|reactome:R-HSA-8953750|go:"GO:0003714"(transcription corepressor activity)|refseq:NP_004173.1|refseq:NP_705582.1|uniprotkb:Q9UBK9(identity)|entrezgene/locuslink:8409(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 rogid:XhE14Q7CfwVXxJ4fTiRQTm3Idvk9606 intact-crc:8BDF876AA2398017|rigid:ZJbIB2nPkMvSxaTG1aKeIIR0KNo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBN7 uniprotkb:P58340 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387225|imex:IM-22301-1432 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:D2127C2D6DD84482|rigid:t7cjGfCdlZrl9ZFBjeTmuidbTJ8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9UBN7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387247|imex:IM-22301-1433 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:D72D9BF5C8D0A3DF|rigid:RyuuzRZ375whO16kaTlMkZ/VnfY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9UBN7 intact:EBI-9356629 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387269|imex:IM-22301-1434 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:A9C5A73073634C70|rigid:ArUrkOWjzYKYkKaj9RRHM9Eyr4s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBN7 uniprotkb:Q53FC7 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 intact:EBI-9356749 psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387291|imex:IM-22301-1435 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:54BC0545FBE38B9E|rigid:ly71Us5q+cMTF3pPNFhIzlwN8pw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9UBN7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387313|imex:IM-22301-1436 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:3C89BEC86D25CCFB|rigid:4pC/ceLojaXn2GViN6Nu3ugy7rE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9UBN7 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387332|imex:IM-22301-1437 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:31126EA896FF1624|rigid:YQJuhjWF5Okt2WqNYO6/98Ujh/w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9UBN7 intact:EBI-9356686 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:q96be0_human(display_long) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387354|imex:IM-22301-1438 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:328520A18B79CDAE|rigid:FvmevhKViikf5G4P+HKDq5wVZfs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q9UBN7 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387376|imex:IM-22301-1439 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 intact-crc:13B6C57C4783FE49|rigid:UdKwjPK7lePsWbph4+sUpFovalA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBN7 uniprotkb:Q9UNE7 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387395|imex:IM-22301-1440 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:77C1FE4A053BE612|rigid:OdgF8zDuH1r3btmfoQgZB6anYHI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBN7 uniprotkb:Q9HB71 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387417|imex:IM-22301-1441 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:F39835E54C7B8C90|rigid:whBFH1wXTebBLgQQQitvpi/W2cQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UBN7 uniprotkb:Q9BPW0 intact:EBI-301697|uniprotkb:O94975|uniprotkb:Q96CY0|uniprotkb:Q6NT75|uniprotkb:Q7L3E5|ensembl:ENSP00000334061|ensembl:ENSP00000365804|ensembl:ENSP00000496013|ensembl:ENSP00000496046 intact:EBI-9356778 psi-mi:hdac6_human(display_long)|uniprotkb:HDAC6(gene name)|psi-mi:HDAC6(display_short)|uniprotkb:KIAA0901(gene name synonym)|uniprotkb:JM21(orf name)|uniprotkb:Tubulin-lysine deacetylase HDAC6(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387436|imex:IM-22301-1442 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006476"(protein deacetylation)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0005874"(microtubule)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032418"(lysosome localization)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0005901"(caveola)|go:"GO:0035967"(cellular response to topologically incorrect protein)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042903"(tubulin deacetylase activity)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043204"(perikaryon)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000094631(gene)|ensembl:ENST00000334136(transcript)|ensembl:ENST00000376619(transcript)|ensembl:ENST00000643374(transcript)|ensembl:ENST00000644068(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003779"(actin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0048668"(collateral sprouting)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060632"(regulation of microtubule-based movement)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070842"(aggresome assembly)|go:"GO:0048487"(beta-tubulin binding)|reactome:R-HSA-5617833|reactome:R-HSA-8878166|reactome:R-HSA-8940973|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|go:"GO:0070846"(Hsp90 deacetylation)|go:"GO:0070848"(response to growth factor)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:Q9UBN7|rcsb pdb:3C5K|rcsb pdb:3GV4|rcsb pdb:3PHD|go:"GO:0070845"(polyubiquitinated misfolded protein transport)|rcsb pdb:5B8D|rcsb pdb:5EDU|rcsb pdb:5KH3|rcsb pdb:5KH7|rcsb pdb:5KH9|rcsb pdb:5WBN|rcsb pdb:5WPB|rcsb pdb:6CE6|rcsb pdb:6CE8|rcsb pdb:6CEA|rcsb pdb:6CEC|rcsb pdb:6CED|rcsb pdb:6CEE|rcsb pdb:6CEF|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3371511|reactome:R-HSA-350054|refseq:NP_006035.2|refseq:NP_001308155.1|refseq:NP_001308156.1|refseq:NP_001308157.1|refseq:NP_001308158.1|dip:DIP-27544N|uniprotkb:Q9UBN7(identity)|human orfeome collection:2397(identity)|ddbj/embl/genbank:BC013737(identity)|entrezgene/locuslink:10013(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:j4lt2D2ZcySF9FFqSlCo3a+Q3VU9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:3AD4E311A412CD3D|rigid:hP4TGkhS60Wf2oU34grEmfQD3UQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9UGR2 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387458|imex:IM-22301-1443 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3|uniprotkb:Q9UGR2(identity)|entrezgene/locuslink:23264(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/01/23 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:A9CDCC20ED879221|rigid:dve4Vm2vrdW7pb0OArl7UTF2zMg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9UGR2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-948845|ensembl:ENSP00000345793|uniprotkb:Q5TFX9|uniprotkb:Q8TBT9|uniprotkb:Q9H8B6|uniprotkb:Q9UGQ9|uniprotkb:Q9UGR0|uniprotkb:Q9UGR1|uniprotkb:Q9UK03|uniprotkb:Q9UPW9|uniprotkb:A7YY88|uniprotkb:B2RCA4 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:z3h7b_human(display_long)|uniprotkb:Rotavirus 'X'-associated non-structural protein(gene name synonym)|uniprotkb:ZC3H7B(gene name)|psi-mi:ZC3H7B(display_short)|uniprotkb:KIAA1031(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387478|imex:IM-22301-1444 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000100403(gene)|ensembl:ENST00000352645(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036236|interpro:IPR036855|interpro:IPR039691|refseq:NP_060060.3|uniprotkb:Q9UGR2(identity)|entrezgene/locuslink:23264(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/01/23 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:OoA5aL/8pJANSn6oKUqJsMWbAgY9606 intact-crc:199E308313167A0F|rigid:+I35WiswgbFQiRo3/xA0+SOs0VA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99471 uniprotkb:Q9UHV9 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387498|imex:IM-22301-1445 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N|uniprotkb:Q99471(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:248CAF74F8347C99|rigid:uEzYnEQeKfV5GMwzggsBEaoZNuo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHV9 uniprotkb:Q9UHV9 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387515|imex:IM-22301-1446 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:B90122BF82F32E22|rigid:mMYbtW9n3STH+1ElrK0AfU2BBxM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q12894 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387533|imex:IM-22301-1447 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4|uniprotkb:Q9UJ88(identity)|entrezgene/locuslink:7866(identity)|human orfeome collection:5250(identity)|ddbj/embl/genbank:BC001676(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/11/01 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 intact-crc:BDF2E924E99E4F1D|rigid:SIT+URT9u5iMfwA1hSySbm0XRM0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12894 uniprotkb:Q13200 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387554|imex:IM-22301-1448 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4|uniprotkb:Q9UJ88(identity)|entrezgene/locuslink:7866(identity)|human orfeome collection:5250(identity)|ddbj/embl/genbank:BC001676(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/11/01 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:D69B96F2CBF5D192|rigid:YB9f0zXRPoGDWyFAgpfF5uLqLm8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12894 uniprotkb:Q3UJD6-1 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387576|imex:IM-22301-1449 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4|uniprotkb:Q9UJ88(identity)|entrezgene/locuslink:7866(identity)|human orfeome collection:5250(identity)|ddbj/embl/genbank:BC001676(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/11/01 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:72A49C925D288902|rigid:jhG87NIPCO8rRGty1OXT0naV4zg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12894 uniprotkb:Q9BTE6-2 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387597|imex:IM-22301-1450 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4|uniprotkb:Q9UJ88(identity)|entrezgene/locuslink:7866(identity)|human orfeome collection:5250(identity)|ddbj/embl/genbank:BC001676(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/11/01 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:775D1A912BFB09D0|rigid:HscX9kxJfJaTSzSwlcuBvF7oegg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95817 uniprotkb:Q9UJY1 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387619|imex:IM-22301-1451 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|human orfeome collection:5066(identity)|ddbj/embl/genbank:BC006418(identity) ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1|uniprotkb:Q9UJY1(identity)|entrezgene/locuslink:26353(identity)|human orfeome collection:4066(identity)|ddbj/embl/genbank:BC002673(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606 intact-crc:A3475C54C6234FE0|rigid:vSeNfdyshA5eNQFPmd6p/iQjW5I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9UJY1 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387641|imex:IM-22301-1452 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1|uniprotkb:Q9UJY1(identity)|entrezgene/locuslink:26353(identity)|human orfeome collection:4066(identity)|ddbj/embl/genbank:BC002673(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606 intact-crc:7CA8365B3F5374DF|rigid:pxq5OJxtAZ/5mYiBTVU5bl4/fjs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q9UJY1 intact:EBI-9356749 intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6 psi-mi:q53fc7_human(display_long) psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387663|imex:IM-22301-1453 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1|uniprotkb:Q9UJY1(identity)|entrezgene/locuslink:26353(identity)|human orfeome collection:4066(identity)|ddbj/embl/genbank:BC002673(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606 intact-crc:8338BF2639982FB5|rigid:foyM/MnHkyXsFdI6fZ8cobbT2CU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9UKT8 intact:EBI-9356629 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387685|imex:IM-22301-1454 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 intact-crc:F1E29E73EFA29B21|rigid:LSFd/bINPGiNebQYv0M6j3U4WgI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:Q53FC7 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-9356749 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387707|imex:IM-22301-1455 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:B8D3CD93B2BD88D7|rigid:2ktJjTVTZeSlejMIls4h2onQun0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9UKT8 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387729|imex:IM-22301-1456 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 intact-crc:0E279C2CA1B7418E|rigid:ljohJs9yfTTpaEWtoDkzRY0weeg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:B4DYC6 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-9357028 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387748|imex:IM-22301-1457 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:45FDE79A2EEA0E1D|rigid:+trIYAoLlNx+w8/88hUFqOfHQFA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:P07900 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387768|imex:IM-22301-1458 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:C250F2C6CCC54D9C|rigid:9n1OL+55Zb3hQwE+5mbzZbXA7ts false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:P31948 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387789|imex:IM-22301-1459 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:B3060FC8381467F3|rigid:8m6nPrDyQfgXhxIEWut2EBTyk60 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:Q9UIM3 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387808|imex:IM-22301-1460 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:A05B8FECE4D849F3|rigid:Plfbq/MILwupgJIKDpw+FK68Hnc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:Q16543 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387827|imex:IM-22301-1461 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:948DE5AA84D09A32|rigid:ichpweB38uwFiOePcGvHG31a1Y8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:Q9HB71 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387847|imex:IM-22301-1462 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:4AD2094CB3EF6D51|rigid:9eaX8yOdyvnu27J6sSfJWq4ZhaE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q9UKT8 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387866|imex:IM-22301-1463 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 intact-crc:30D866E46DC408C7|rigid:6sBKo8PJiHD/JP3gO6mdy458PwU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT8 uniprotkb:Q9BPW0 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-9356778 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387885|imex:IM-22301-1464 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UKT8(identity)|human orfeome collection:7909(identity)|ddbj/embl/genbank:BC018738(identity)|entrezgene/locuslink:26190(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:E8689FE756150B98|rigid:XjFAH6r4EQBDIvTFcb2JfKxbGdI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL15 uniprotkb:Q15773 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387907|imex:IM-22301-1465 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|human orfeome collection:11688(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:6A92E5FC455B3171|rigid:urB1MhVf4eZvPAp0hWHQBizBLWk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53FC7 uniprotkb:Q9UL15 intact:EBI-9356749 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:q53fc7_human(display_long) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387929|imex:IM-22301-1466 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|human orfeome collection:11688(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 intact-crc:368924EFA15344E6|rigid:FuV+C4u0FO9CrwjBcMwCk/4SURk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL15 uniprotkb:Q03933 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387951|imex:IM-22301-1467 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|human orfeome collection:11688(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:0F0CC4182920C8F6|rigid:ItGGYG6xFEdqqe9nLVzFmOM6Gnw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9UL15 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387970|imex:IM-22301-1468 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|human orfeome collection:11688(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 intact-crc:4598B40E8304C648|rigid:XZpRpGZONst02kRQD4B+JZl1lrQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL58 uniprotkb:Q8K2C9 intact:EBI-6427600|ensembl:ENSP00000278319|ensembl:ENSP00000393202|uniprotkb:Q96C84 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 psi-mi:zn215_human(display_long)|uniprotkb:ZNF215(gene name)|psi-mi:ZNF215(display_short)|uniprotkb:BAZ2(gene name synonym)|uniprotkb:BWSCR2-associated zinc finger protein 2(gene name synonym)|uniprotkb:ZKSCAN11(gene name synonym)|uniprotkb:Zinc finger protein with KRAB and SCAN domains 11(gene name synonym) psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9387992|imex:IM-22301-1469 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149054(gene)|ensembl:ENST00000278319(transcript)|ensembl:ENST00000414517(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-HSA-212436|refseq:NP_037382.2|refseq:XP_006718374.1|uniprotkb:Q9UL58(identity)|entrezgene/locuslink:7762(identity)|human orfeome collection:6301(identity)|ddbj/embl/genbank:BC014538(identity) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8guuDKqYpikcIpNn23AYznhy3h89606 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 intact-crc:0CBE93D5BB1706E7|rigid:BHtIhf5zPXsRtv7p8aNDEZJkumU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL58 uniprotkb:Q53FC7 intact:EBI-6427600|ensembl:ENSP00000278319|ensembl:ENSP00000393202|uniprotkb:Q96C84 intact:EBI-9356749 psi-mi:zn215_human(display_long)|uniprotkb:ZNF215(gene name)|psi-mi:ZNF215(display_short)|uniprotkb:BAZ2(gene name synonym)|uniprotkb:BWSCR2-associated zinc finger protein 2(gene name synonym)|uniprotkb:ZKSCAN11(gene name synonym)|uniprotkb:Zinc finger protein with KRAB and SCAN domains 11(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388013|imex:IM-22301-1470 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149054(gene)|ensembl:ENST00000278319(transcript)|ensembl:ENST00000414517(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-HSA-212436|refseq:NP_037382.2|refseq:XP_006718374.1|uniprotkb:Q9UL58(identity)|entrezgene/locuslink:7762(identity)|human orfeome collection:6301(identity)|ddbj/embl/genbank:BC014538(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8guuDKqYpikcIpNn23AYznhy3h89606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:6DD22577F5CAA03D|rigid:x0DsU7wpNnw3cT5H+jTcsx61OA8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL58 uniprotkb:Q96BE0 intact:EBI-6427600|ensembl:ENSP00000278319|ensembl:ENSP00000393202|uniprotkb:Q96C84 intact:EBI-9356686 psi-mi:zn215_human(display_long)|uniprotkb:ZNF215(gene name)|psi-mi:ZNF215(display_short)|uniprotkb:BAZ2(gene name synonym)|uniprotkb:BWSCR2-associated zinc finger protein 2(gene name synonym)|uniprotkb:ZKSCAN11(gene name synonym)|uniprotkb:Zinc finger protein with KRAB and SCAN domains 11(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388035|imex:IM-22301-1471 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149054(gene)|ensembl:ENST00000278319(transcript)|ensembl:ENST00000414517(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated box)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|interpro:IPR038269|reactome:R-HSA-212436|refseq:NP_037382.2|refseq:XP_006718374.1|uniprotkb:Q9UL58(identity)|entrezgene/locuslink:7762(identity)|human orfeome collection:6301(identity)|ddbj/embl/genbank:BC014538(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8guuDKqYpikcIpNn23AYznhy3h89606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:5041840A0FD3BF36|rigid:GF+Sb4flwyRajM+4x8tL6iPqR6o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9ULJ7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-5653671|uniprotkb:Q6N064|uniprotkb:A8K4V3|uniprotkb:Q6ZSE6|uniprotkb:B4DHJ6|uniprotkb:E9PDW0|ensembl:ENSP00000425658 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:anr50_human(display_long)|uniprotkb:KIAA1223(gene name synonym)|uniprotkb:ANKRD50(gene name)|psi-mi:ANKRD50(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388057|imex:IM-22301-1472 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) dip:DIP-47302N|refseq:NP_001161354.1|refseq:NP_065070.1|refseq:XP_016863960.1|ensembl:ENSG00000151458(gene)|ensembl:ENST00000504087(transcript)|go:"GO:0005768"(endosome)|go:"GO:0015031"(protein transport)|go:"GO:0032456"(endocytic recycling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q9ULJ7|uniprotkb:Q9ULJ7(identity)|ddbj/embl/genbank:BC024725(identity)|human orfeome collection:8161(identity)|entrezgene/locuslink:57182(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:cP1xkkSlKwersPLj/gvrnWOjm+89606 intact-crc:992231007A436214|rigid:wNl4nrknW0iX/LmD8VCElXC9JSM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9UMP2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-9388082 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388079|imex:IM-22301-1473 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 intact-crc:49C22D20094F00C1|rigid:94h5ndl5nKQE4iOkwz6deRPO3Wo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q15773 intact:EBI-9388082 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388104|imex:IM-22301-1474 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:7B8732E6097E97DC|rigid:IVynhAsQRdNCYnAsGZqpjuCGJ18 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q6PK50 intact:EBI-9388082 intact:EBI-9356629 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388126|imex:IM-22301-1475 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:B4E23891BC44CF4C|rigid:9glTfqaM3ALExiQJf0iRoaEXRhQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q53FC7 intact:EBI-9388082 intact:EBI-9356749 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388148|imex:IM-22301-1476 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:82C9ADA27A147D06|rigid:32K0Jeq8G5BR7hqtwywWtlbmhio false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q3UJD6-1 intact:EBI-9388082 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388170|imex:IM-22301-1477 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:7E43FCDC65CD9C30|rigid:jwZCBKXuejIXbQj4BlQF1+xFVrY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q96BE0 intact:EBI-9388082 intact:EBI-9356686 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388191|imex:IM-22301-1478 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:63E98A36623363BA|rigid:4CEXneK1KqCIA6UNnVej2Jd3EaY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:P31948 intact:EBI-9388082 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388213|imex:IM-22301-1479 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:AB483CDF8221A63A|rigid:lDWnbvDC90N4Q98xAIEzBArfc4M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIM3 uniprotkb:Q9UMP2 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9388082 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388232|imex:IM-22301-1480 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 intact-crc:4369B0FF7002CDC0|rigid:o01lCOyaFX6upKGXcm0CcHNUrL4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q9HB71 intact:EBI-9388082 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388251|imex:IM-22301-1481 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:220C56BC72986A0C|rigid:/a6tBd9RJ97jVkMqtz8mlSD/Dnk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9UMP2 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-9388082 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388270|imex:IM-22301-1482 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 intact-crc:296CC6B74F34AA3E|rigid:dyYvp+bH5ZRkcKJ96082/LjwCGk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMP2 uniprotkb:Q9BPW0 intact:EBI-9388082 intact:EBI-9356778 psi-mi:q9ump2_human(display_long)|uniprotkb:G7(gene name)|psi-mi:G7(display_short) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388292|imex:IM-22301-1483 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR027417|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR036187|go:"GO:0005524"(ATP binding)|go:"GO:0006298"(mismatch repair)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032301"(MutSalpha complex)|uniprotkb:Q9UMP2(identity)|human orfeome collection:6760(identity)|entrezgene/locuslink:4439(identity)|ddbj/embl/genbank:BC001358(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:z/+zprlEPeKGFi9UON4FFKK7XxI9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:C27B54F87378EA59|rigid:k9NElFaXG5Ko7wWLL6cA6//Js4A false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q9UMW8 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388314|imex:IM-22301-1484 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:D6D67DA8005CDDBB|rigid:Xc/4aPEtcTQHYE6D7wKqEr2MeqU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:P58340 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388333|imex:IM-22301-1485 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:F7A2A5B38D56E1B9|rigid:F3XX+RxxFjFa9EtEISSGeGuh2tI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9UMW8 intact:EBI-9356629 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388355|imex:IM-22301-1486 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:28F831F29256B28C|rigid:ek6aRlb0+9WS39myqxnvt6CfMkA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:Q8IVD9 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388377|imex:IM-22301-1487 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:AB8155B86B770762|rigid:Yf+MMQIdEgEjb/xUiYDOrXoQKiw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9UMW8 intact:EBI-9357028 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:b4dyc6_human(display_long) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388396|imex:IM-22301-1488 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:8ABD1F8E2C6305D0|rigid:Bkl+UD1gPVs9NK57LijFmW7htV0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:O43765 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388416|imex:IM-22301-1489 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:0B5F492AF6A658BF|rigid:H0Fu7FXkW1gcaM+nPw1FkBj2lRs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9UMW8 intact:EBI-9356686 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:q96be0_human(display_long) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388438|imex:IM-22301-1490 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:FFF383554C211E7A|rigid:+9q1swrYcD3+xKJ0CjDbu/0DOCc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P31948 uniprotkb:Q9UMW8 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388460|imex:IM-22301-1491 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:FDB55EBBA0690DA0|rigid:dcaulsblFQgtltSyOaQHoe5JTFw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:Q9UIM3 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388479|imex:IM-22301-1492 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:4BDFF8B5024CA3F9|rigid:GihUqWdeh6X10IcYIQ4F8OEnDXs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:Q9HB71 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388498|imex:IM-22301-1493 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:BA3056BFECB8AF60|rigid:EUOnExIawEKh5J30Gq8ODquWyqA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9UMW8 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388517|imex:IM-22301-1494 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:C1B68C124559B9D9|rigid:4kJtYW8i8wwQX0KS43IudJ07LKg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BPW0 uniprotkb:Q9UMW8 intact:EBI-9356778 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388539|imex:IM-22301-1495 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 intact-crc:A45ABC6F6FD1E340|rigid:SwR6qKwb4axdBmOfk9IgdtoyKTk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UMW8 uniprotkb:Q99614 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388561|imex:IM-22301-1496 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N|uniprotkb:Q9UMW8(identity)|entrezgene/locuslink:11274(identity)|ddbj/embl/genbank:BC014896(identity)|human orfeome collection:242(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:723A2E16766B7DDC|rigid:5QwIf9Dx5t6q67n4AUH23SmInUU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P58340 uniprotkb:Q9UNE7 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388580|imex:IM-22301-1497 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:71E12CC4B1E82D50|rigid:2qmHO4ZfFgfUSPgzB6Bf0pCVIqA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9UNE7 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388602|imex:IM-22301-1498 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:BDE0547F4617D13A|rigid:/AVQCexaYBwwwmXrJfHYhha0AF4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9UNE7 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388623|imex:IM-22301-1499 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:BA77E50BBA44D784|rigid:zDOe7hXP7uflLdrcppezo8xNRH8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03933 uniprotkb:Q9UNE7 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388645|imex:IM-22301-1500 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:7BEB045C515DAA55|rigid:Lu95nL3lj1QUu+y+4wveEWwN4mU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:O95816 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388664|imex:IM-22301-1501 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|ddbj/embl/genbank:BC125039(identity)|human orfeome collection:56530(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:72475ADB3AC955DE|rigid:7cLd0nPZwmzRI3CBqgpBfb4W2So false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q9HAV2 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-9357141 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:q9hav2_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388686|imex:IM-22301-1502 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) interpro:IPR027725|interpro:IPR010542(Vertebrate heat shock transcription factor)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|uniprotkb:Q9HAV2(identity)|human orfeome collection:5981(identity)|entrezgene/locuslink:3297(identity)|ddbj/embl/genbank:BC014638(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:dTTGJ90oU22lcHMVBXC6HjxxE6A9606 intact-crc:3BB678A350643B07|rigid:phcoLy9i5d8nrvJgC/uhCo5bGVQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNE7 uniprotkb:Q13200 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388708|imex:IM-22301-1503 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:E5FC8225DDADE922|rigid:TQYbXpduKQ0RXp7OrwJbiAEmvdI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q9UNF1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-725832|uniprotkb:O76058|uniprotkb:Q5BJF3|uniprotkb:Q8NAL6|uniprotkb:Q9H218|uniprotkb:Q9P0U9|uniprotkb:A6NMX0|uniprotkb:Q9UM52|ensembl:ENSP00000218439|ensembl:ENSP00000364193|ensembl:ENSP00000364198|ensembl:ENSP00000364209|ensembl:ENSP00000379526 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:magd2_human(display_long)|uniprotkb:MAGE-D2 antigen(gene name synonym)|uniprotkb:Breast cancer-associated gene 1 protein(gene name synonym)|uniprotkb:11B6(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein JCL-1(gene name synonym)|uniprotkb:MAGED2(gene name)|psi-mi:MAGED2(display_short)|uniprotkb:BCG1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388730|imex:IM-22301-1504 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_055414.2|refseq:NP_803182.1|refseq:NP_957516.1|ensembl:ENSG00000102316(gene)|ensembl:ENST00000218439(transcript)|ensembl:ENST00000375053(transcript)|ensembl:ENST00000375058(transcript)|ensembl:ENST00000375068(transcript)|ensembl:ENST00000396224(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0016020"(membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9UNF1|reactome:R-HSA-114608|dip:DIP-50722N|uniprotkb:Q9UNF1(identity)|human orfeome collection:3158(identity)|entrezgene/locuslink:10916(identity)|ddbj/embl/genbank:BC000304(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:fXavezmKy58aGuVgzvDYjwNw3B89606 intact-crc:3DDEEEF00064D73D|rigid:wC1loet8b6pji5U/g9tYC14MTH0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q13451 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388749|imex:IM-22301-1505 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:E543BFFD8022AC81|rigid:6t9XzJzafi+ayuj8oGu4X8FFwFI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q15773 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388768|imex:IM-22301-1506 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:701E0BD4AD85D4B8|rigid:FP+88wovLaV9cQINLoPHuGM6t8o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q03933 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388790|imex:IM-22301-1507 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:54947595C3325D23|rigid:i/ThBeXfbhm0wPadaFgw2RFcnRo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q8IVD9 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388809|imex:IM-22301-1508 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:6D0D7D0AAC3FAA32|rigid:HXmRdQHDSC44jeRYxesvgMamKdo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q13200 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388828|imex:IM-22301-1509 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:B16B92F23E6A7270|rigid:Xayq3PZdp6zCtjNtN4r7kWads/w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q96BE0 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-9356686 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388850|imex:IM-22301-1510 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:C82FCC4BDE3E3B9C|rigid:dFOPl+cYEzyrqOjNAlvTTGvpAqE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q9UIM3 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388872|imex:IM-22301-1511 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:20B2474E7A56C1A4|rigid:sNrbyTBAdPuyJTK1W5qjTl5oREw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q9UNE7 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388891|imex:IM-22301-1512 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|human orfeome collection:5219(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:E536843E77EF6E3B|rigid:dFbsbLNFlss4AUQlBCkapZ1ekzE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q9HB71 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388913|imex:IM-22301-1513 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:7E3BC3B0154B1930|rigid:xQOgqDZwte7vC35cF+ff/5+Gksw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q9BTE6-2 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-9357295|ensembl:ENSP00000353355 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388932|imex:IM-22301-1514 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) psi-mi:"MI:0469"(intact) - isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 intact-crc:9D9A6A97260898EC|rigid:vljHyobJcIhCAB4d86eR+orwPoQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q9BPW0 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-9356778 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388954|imex:IM-22301-1515 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:DB11324C25194CC2|rigid:tmiMfYWnuG2/h+v9H/zCL+cbFUY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ16 uniprotkb:Q99614 intact:EBI-1111783|uniprotkb:A9Z1Y1|uniprotkb:O14982|uniprotkb:O95555|uniprotkb:Q1MTM8|uniprotkb:Q5W129|uniprotkb:Q9H0P3|uniprotkb:Q9H548|uniprotkb:Q9NQ68|uniprotkb:Q9NQN6|uniprotkb:Q6P2G1|ensembl:ENSP00000347457 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 psi-mi:dyn3_human(display_long)|uniprotkb:KIAA0820(gene name synonym)|uniprotkb:DNM3(gene name)|psi-mi:DNM3(display_short)|uniprotkb:Dynamin, testicular(gene name synonym)|uniprotkb:T-dynamin(gene name synonym) psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388976|imex:IM-22301-1516 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265181.1|refseq:NP_001129599.1|refseq:NP_056384.2|refseq:XP_005245136.1|refseq:XP_005245137.1|ensembl:ENSG00000197959(gene)|ensembl:ENST00000355305(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006897"(endocytosis)|go:"GO:0007416"(synapse assembly)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031798"(type 1 metabotropic glutamate receptor binding)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043197"(dendritic spine)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061025"(membrane fusion)|go:"GO:0061828"(apical tubulobulbar complex)|go:"GO:0061829"(basal tubulobulbar complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR030381|rcsb pdb:3L43|rcsb pdb:5A3F|reactome:R-HSA-166016|reactome:R-HSA-177504|reactome:R-HSA-2132295|go:"GO:0050803"(regulation of synapse structure or activity)|reactome:R-HSA-8856828|reactome:R-HSA-437239|dip:DIP-36244N|uniprotkb:Q9UQ16(identity)|human orfeome collection:12196(identity)|ddbj/embl/genbank:BC064546(identity)|entrezgene/locuslink:26052(identity) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:t1g0cjVLI4Bf0hbMJvoM4zKkVYk9606 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 intact-crc:62B24A28C564E53E|rigid:uEO59hHFytf224AxJgnFLAM8Cc0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13451 uniprotkb:Q9Y239 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9388995|imex:IM-22301-1517 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:99A020575A768126|rigid:Pxm+EfDUy9PAYS5oKkO+q6Sv/IM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8K2C9 uniprotkb:Q9Y239 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389014|imex:IM-22301-1518 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity)|human orfeome collection:70396(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:0E7B2D3E28FA87C1|rigid:bGvy0LIpauY5rIheCr4nTs4S9P8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q15773 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389035|imex:IM-22301-1519 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:57B3F1262BE1FA7C|rigid:P04gKZmNltXRi08eJ26eLNbq5Yk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9Y239 intact:EBI-9356629 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389057|imex:IM-22301-1520 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:3F9C67313DB647A4|rigid:nBlWfM1pWaPVk3ZB5oU7ejh2zqM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q53FC7 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-9356749 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389079|imex:IM-22301-1521 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:3A376DEB2A11E4B8|rigid:XQmLx1jXEvtusTU2oYrVk0suEBM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9Y239 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389101|imex:IM-22301-1522 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:2564E2B9AA4A7556|rigid:7eYvTw4jURr/R+LgElBY6vtsNK0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:B4DYC6 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-9357028 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389120|imex:IM-22301-1523 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:C9111A082BD129D9|rigid:mbTll/enYujPlm4r2b5RZGatatQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q13200 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389140|imex:IM-22301-1524 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:9296364AFB64BD5F|rigid:bXglSYWIi4U5pgBpxh90bzks0AM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q3UJD6-1 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-9361730|ensembl:ENSMUSP00000006854 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:q3ujd6-1(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389162|imex:IM-22301-1525 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000006854(transcript)|uniprotkb:Q3UJD6-1(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_001161844.1(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:UHOaA/VZzz7pURJZi28W5BJZGfY10090 intact-crc:27F3584D5DB8547F|rigid:TD8pviBDBYbTQIWlSj4AMmAWLgQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9Y239 intact:EBI-9356686 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:q96be0_human(display_long) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389183|imex:IM-22301-1526 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:B659869F24767AED|rigid:3JjWPLLJ6K1KB34+lEEZENU4tO8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:P07900 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389205|imex:IM-22301-1527 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:77890C0874322DD4|rigid:ENpvyAeyhNSXiDlp6Ty8Jr2ZMEk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q9UIM3 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389226|imex:IM-22301-1528 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:D6FDA945DF0E8E9D|rigid:zvEyRE2E8aFWUE+GkImdfOIlQQg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9Y239 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389245|imex:IM-22301-1529 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 intact-crc:4EE4D29A0D8A28E5|rigid:R/9QFe99mp8p05WNQhSG5qn300w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q9HB71 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389265|imex:IM-22301-1530 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:D594B17722D2AB95|rigid:+zTjTsSWPYHmY5VcVA9o/9trPRg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q15185 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389284|imex:IM-22301-1531 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:B4DP21(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:A86F8CD1681735D7|rigid:eZsBwjJ7O+ShXTO1smrbL0JIvdw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:B3KTT5 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-8783896 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:b3ktt5_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389304|imex:IM-22301-1532 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) interpro:IPR029047|interpro:IPR029048|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|refseq:NP_005336.3|go:"GO:0005524"(ATP binding)|interpro:IPR043129|uniprotkb:B3KTT5(identity)|human orfeome collection:6708(identity)|entrezgene/locuslink:3303(identity)|ddbj/embl/genbank:BC009322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:ftjY21EqCh3VNMeXxRtnaRsoTj09606 intact-crc:68A383AF042344FC|rigid:YhQbXoSCRTgp4C2JxAMjWtWKY5M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y239 uniprotkb:Q9BPW0 intact:EBI-1051262|uniprotkb:Q549U4|uniprotkb:Q8IWF5|uniprotkb:B4DTU3|ensembl:ENSP00000222823 intact:EBI-9356778 psi-mi:nod1_human(display_long)|uniprotkb:Caspase recruitment domain-containing protein 4(gene name synonym)|uniprotkb:NOD1(gene name)|psi-mi:NOD1(display_short)|uniprotkb:CARD4(gene name synonym) psi-mi:q9bpw0_human(display_long)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389326|imex:IM-22301-1533 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006083.1|refseq:XP_011513381.1|refseq:XP_011513382.1|refseq:XP_011513383.1|refseq:XP_005249625.1|refseq:XP_005249629.1|ensembl:ENSG00000106100(gene)|ensembl:ENST00000222823(transcript)|go:"GO:0002221"(pattern recognition receptor signaling pathway)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009595"(detection of biotic stimulus)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016045"(detection of bacterium)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001315(Caspase Recruitment)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR032675|interpro:IPR041075|go:"GO:0071225"(cellular response to muramyl dipeptide)|interpro:IPR041267|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|rcsb pdb:2B1W|rcsb pdb:2DBD|rcsb pdb:2NSN|rcsb pdb:2NZ7|rcsb pdb:4E9M|rcsb pdb:4JQW|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|go:"GO:1904417"(positive regulation of xenophagy)|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_006715696.1|dip:DIP-41064N|uniprotkb:Q9Y239(identity)|human orfeome collection:2450(identity)|entrezgene/locuslink:10392(identity)|ddbj/embl/genbank:BC040339(identity) interpro:IPR041753|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|uniprotkb:Q9BPW0(identity)|human orfeome collection:2715(identity)|entrezgene/locuslink:5536(identity)|ddbj/embl/genbank:BC001970(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:JGA4XuGCPNqNeESAMbr7aKVgZP89606 rogid:urqSgXIjxir7gVT9+se7jwpYOU49606 intact-crc:C3466BA54330E7AE|rigid:LdWnAPNHmBi2ccc84b5fR70BKIg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PK50 uniprotkb:Q9Y243 intact:EBI-9356629 intact:EBI-296115|uniprotkb:Q0VAA6|uniprotkb:Q5VTI1|uniprotkb:Q5VTI2|uniprotkb:Q96QV3|uniprotkb:Q9UFP5|ensembl:ENSP00000263826|ensembl:ENSP00000479081|ensembl:ENSP00000500582|ensembl:ENSP00000505276 psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:akt3_human(display_long)|uniprotkb:AKT3(gene name)|psi-mi:AKT3(display_short)|uniprotkb:PKBG(gene name synonym)|uniprotkb:RAC-PK-gamma(gene name synonym)|uniprotkb:Protein kinase Akt-3(gene name synonym)|uniprotkb:Protein kinase B gamma(gene name synonym)|uniprotkb:STK-2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389348|imex:IM-22301-1534 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001193658.1|refseq:NP_005456.1|refseq:NP_859029.1|refseq:XP_005273051.1|refseq:XP_005273052.1|dip:DIP-32584N|ensembl:ENSG00000117020(gene)|ensembl:ENSG00000275199(gene)|ensembl:ENST00000263826(transcript)|ensembl:ENST00000621586(transcript)|ensembl:ENST00000673466(transcript)|ensembl:ENST00000680118(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-211163|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034675|interpro:IPR039026|interpro:IPR039029|mint:Q9Y243|rcsb pdb:2X18|reactome:R-HSA-111447|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|uniprotkb:Q9Y243(identity)|human orfeome collection:56787(identity)|ddbj/embl/genbank:BC121154(identity)|entrezgene/locuslink:10000(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 rogid:pwxyw/nuFIUqnuBVKH3HNoNW7309606 intact-crc:A3866E5213A43A64|rigid:bdKaZHcVHu9Xe2SyRUP3lua9cRg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P07900 uniprotkb:Q9Y243 intact:EBI-296047|intact:EBI-1642144|uniprotkb:Q2PP14|ensembl:ENSP00000216281|uniprotkb:Q5CAQ6|uniprotkb:Q5CAQ7|uniprotkb:Q9BVQ5|intact:EBI-2211817|uniprotkb:A8K500|uniprotkb:B3KPJ9 intact:EBI-296115|uniprotkb:Q0VAA6|uniprotkb:Q5VTI1|uniprotkb:Q5VTI2|uniprotkb:Q96QV3|uniprotkb:Q9UFP5|ensembl:ENSP00000263826|ensembl:ENSP00000479081|ensembl:ENSP00000500582|ensembl:ENSP00000505276 psi-mi:hs90a_human(display_long)|uniprotkb:HSP90AA1(gene name)|psi-mi:HSP90AA1(display_short)|uniprotkb:HSP90A(gene name synonym)|uniprotkb:HSPC1(gene name synonym)|uniprotkb:Heat shock 86 kDa(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-38(gene name synonym)|uniprotkb:HSPCA(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 2(gene name synonym) psi-mi:akt3_human(display_long)|uniprotkb:AKT3(gene name)|psi-mi:AKT3(display_short)|uniprotkb:PKBG(gene name synonym)|uniprotkb:RAC-PK-gamma(gene name synonym)|uniprotkb:Protein kinase Akt-3(gene name synonym)|uniprotkb:Protein kinase B gamma(gene name synonym)|uniprotkb:STK-2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389370|imex:IM-22301-1535 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0009409"(response to cold)|go:"GO:0016020"(membrane)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032273"(positive regulation of protein polymerization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903827"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P07900|rcsb pdb:1BYQ|rcsb pdb:1OSF|rcsb pdb:1UY6|rcsb pdb:1UY7|ensembl:ENST00000216281(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000080824(gene)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009408"(response to heat)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043209"(myelin sheath)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043335"(protein unfolding)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051020"(GTPase binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1UY9|rcsb pdb:1UYC|rcsb pdb:1UYD|rcsb pdb:1UYE|rcsb pdb:1UYF|rcsb pdb:1UYG|rcsb pdb:1UYH|rcsb pdb:1UYI|rcsb pdb:1UYK|rcsb pdb:1UYL|rcsb pdb:1UY8|rcsb pdb:1YC1|rcsb pdb:1YC3|rcsb pdb:1YC4|rcsb pdb:1YER|rcsb pdb:1YES|rcsb pdb:1YET|rcsb pdb:2BSM|rcsb pdb:2BT0|rcsb pdb:2BUG|rcsb pdb:2WI1|rcsb pdb:2WI2|rcsb pdb:2WI3|rcsb pdb:2WI4|rcsb pdb:2WI5|rcsb pdb:2WI6|rcsb pdb:2WI7|rcsb pdb:2XAB|rcsb pdb:2XDK|rcsb pdb:2XDL|rcsb pdb:2XDS|rcsb pdb:2XDU|rcsb pdb:2XDX|rcsb pdb:2XHR|rcsb pdb:2XHT|rcsb pdb:2XHX|rcsb pdb:2XJG|rcsb pdb:2XJJ|rcsb pdb:2XJX|rcsb pdb:2XK2|rcsb pdb:2YE2|rcsb pdb:2YE3|rcsb pdb:2YE4|rcsb pdb:2YE5|rcsb pdb:2YE6|rcsb pdb:2YE7|rcsb pdb:2YE8|rcsb pdb:2YE9|rcsb pdb:2YEA|rcsb pdb:2YEB|rcsb pdb:2BYI|rcsb pdb:2BZ5|rcsb pdb:2C2L|rcsb pdb:2CCS|rcsb pdb:2CCT|rcsb pdb:2CCU|rcsb pdb:2FWY|rcsb pdb:2FWZ|rcsb pdb:2H55|rcsb pdb:2JJC|rcsb pdb:2K5B|rcsb pdb:2QF6|rcsb pdb:2QFO|rcsb pdb:2QG0|rcsb pdb:2QG2|rcsb pdb:2UWD|rcsb pdb:2VCI|rcsb pdb:2BYH|rcsb pdb:2VCJ|rcsb pdb:3B25|rcsb pdb:3B26|rcsb pdb:3B27|rcsb pdb:3B28|rcsb pdb:3BM9|rcsb pdb:3BMY|rcsb pdb:3D0B|rcsb pdb:3EKO|rcsb pdb:3EKR|rcsb pdb:3FT5|rcsb pdb:3FT8|rcsb pdb:3HEK|rcsb pdb:3HHU|rcsb pdb:3HYY|rcsb pdb:3HYZ|rcsb pdb:3HZ1|rcsb pdb:3HZ5|rcsb pdb:3INW|rcsb pdb:3B24|rcsb pdb:3INX|rcsb pdb:3K97|rcsb pdb:3K98|rcsb pdb:2YEC|rcsb pdb:2YED|rcsb pdb:2YEE|rcsb pdb:2YEF|rcsb pdb:2YEG|rcsb pdb:2YEH|rcsb pdb:2YEI|rcsb pdb:2YEJ|rcsb pdb:2YI0|rcsb pdb:2YI5|rcsb pdb:2YI6|rcsb pdb:2YI7|rcsb pdb:2YJW|rcsb pdb:2YJX|rcsb pdb:2YK2|rcsb pdb:2YK9|rcsb pdb:2YKB|rcsb pdb:2YKC|rcsb pdb:2YKE|rcsb pdb:2YKI|rcsb pdb:2YKJ|rcsb pdb:4CWF|rcsb pdb:4CWN|rcsb pdb:4CWO|rcsb pdb:4CWP|rcsb pdb:4CWQ|rcsb pdb:4CWR|rcsb pdb:4CWS|rcsb pdb:4CWT|rcsb pdb:4EEH|rcsb pdb:4EFT|rcsb pdb:4EFU|rcsb pdb:4EGH|rcsb pdb:4EGI|rcsb pdb:4EGK|rcsb pdb:4FCP|rcsb pdb:4FCQ|rcsb pdb:4FCR|rcsb pdb:4HY6|rcsb pdb:4JQL|rcsb pdb:4L8Z|rcsb pdb:4L90|rcsb pdb:4L91|rcsb pdb:5LO5|rcsb pdb:5LO6|rcsb pdb:5LQ9|rcsb pdb:5LR1|rcsb pdb:5LR7|rcsb pdb:5LRL|rcsb pdb:5LRZ|rcsb pdb:5LS1|rcsb pdb:5M4E|rcsb pdb:5M4H|rcsb pdb:5NYH|rcsb pdb:5NYI|rcsb pdb:5OCI|rcsb pdb:5OD7|rcsb pdb:5ODX|rcsb pdb:5T21|rcsb pdb:5VYY|rcsb pdb:5XQD|rcsb pdb:5XQE|rcsb pdb:5XR5|rcsb pdb:5XR9|rcsb pdb:5XRB|rcsb pdb:5XRD|rcsb pdb:5XRE|rcsb pdb:5LO1|rcsb pdb:5ZR3|rcsb pdb:6B99|rcsb pdb:6B9A|rcsb pdb:6CEO|rcsb pdb:6CYG|rcsb pdb:6EI5|rcsb pdb:6EL5|rcsb pdb:6ELN|rcsb pdb:6ELO|rcsb pdb:6ELP|rcsb pdb:6EY8|rcsb pdb:6EY9|rcsb pdb:6EYA|rcsb pdb:6EYB|rcsb pdb:6F1N|rcsb pdb:6FCJ|rcsb pdb:6FDP|rcsb pdb:6GP4|rcsb pdb:6GP8|rcsb pdb:6GPF|rcsb pdb:6GPH|rcsb pdb:6CYH|rcsb pdb:6GPO|rcsb pdb:6GPP|rcsb pdb:6GPR|rcsb pdb:6GPT|rcsb pdb:6GPW|rcsb pdb:6GPY|rcsb pdb:6GQ6|rcsb pdb:6GQR|rcsb pdb:6GQS|rcsb pdb:6GQU|rcsb pdb:6GR1|rcsb pdb:6GR3|rcsb pdb:6GR4|rcsb pdb:6GR5|rcsb pdb:6HHR|rcsb pdb:6KSQ|rcsb pdb:6LR9|rcsb pdb:6LSZ|rcsb pdb:6LT8|rcsb pdb:6LTI|rcsb pdb:6LTK|rcsb pdb:6N8X|rcsb pdb:6OLX|rcsb pdb:6TN5|rcsb pdb:6U98|rcsb pdb:6U99|rcsb pdb:6U9A|rcsb pdb:6U9B|rcsb pdb:7LSZ|rcsb pdb:7LT0|reactome:R-HSA-1227986|reactome:R-HSA-1236382|rcsb pdb:6TN4|reactome:R-HSA-1474151|reactome:R-HSA-168928|reactome:R-HSA-192905|reactome:R-HSA-2029482|reactome:R-HSA-203615|reactome:R-HSA-2565942|reactome:R-HSA-3000484|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-399954|reactome:R-HSA-4420097|reactome:R-HSA-5218920|reactome:R-HSA-5336415|reactome:R-HSA-5601884|reactome:R-HSA-5620912|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8863795|reactome:R-HSA-8939211|reactome:R-HSA-9009391|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9634285|reactome:R-HSA-9646399|reactome:R-HSA-9652282|reactome:R-HSA-9665233|reactome:R-HSA-9664565|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|reactome:R-HSA-9679191|rcsb pdb:3MNR|rcsb pdb:3O0I|rcsb pdb:3OW6|rcsb pdb:3OWB|rcsb pdb:3OWD|rcsb pdb:3Q6M|rcsb pdb:3Q6N|rcsb pdb:3QDD|rcsb pdb:3QTF|rcsb pdb:3R4M|rcsb pdb:3R4N|rcsb pdb:3R4O|rcsb pdb:3R4P|rcsb pdb:3R91|rcsb pdb:3R92|rcsb pdb:3K99|rcsb pdb:3RKZ|rcsb pdb:3RLP|rcsb pdb:3RLQ|rcsb pdb:3RLR|rcsb pdb:4L93|rcsb pdb:4L94|rcsb pdb:4LWE|rcsb pdb:4LWF|rcsb pdb:4LWG|rcsb pdb:4LWH|rcsb pdb:4LWI|rcsb pdb:4NH7|rcsb pdb:4NH8|rcsb pdb:4O04|rcsb pdb:4O05|rcsb pdb:4O07|rcsb pdb:4O09|rcsb pdb:4O0B|rcsb pdb:4R3M|rcsb pdb:4U93|rcsb pdb:4W7T|rcsb pdb:4XIP|rcsb pdb:4XIQ|rcsb pdb:4XIR|rcsb pdb:4XIT|rcsb pdb:4YKQ|rcsb pdb:4YKR|rcsb pdb:4YKT|rcsb pdb:4YKU|rcsb pdb:4YKW|rcsb pdb:4YKX|rcsb pdb:4YKY|rcsb pdb:3T0Z|rcsb pdb:3T10|rcsb pdb:3T1K|rcsb pdb:3T2S|rcsb pdb:3TUH|rcsb pdb:3VHA|rcsb pdb:3VHC|rcsb pdb:3VHD|rcsb pdb:3WHA|rcsb pdb:3WQ9|rcsb pdb:4AIF|rcsb pdb:4AWO|rcsb pdb:4AWP|rcsb pdb:3T0H|rcsb pdb:4AWQ|rcsb pdb:4B7P|rcsb pdb:4BQG|rcsb pdb:4BQJ|rcsb pdb:4CGQ|rcsb pdb:4CGU|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:5CF0|rcsb pdb:5FNC|rcsb pdb:5FND|rcsb pdb:5FNF|rcsb pdb:5GGZ|rcsb pdb:5J20|rcsb pdb:5J27|rcsb pdb:5J2V|rcsb pdb:5J2X|rcsb pdb:5J64|rcsb pdb:5J6L|rcsb pdb:5J6M|rcsb pdb:5J6N|rcsb pdb:5J80|rcsb pdb:5J82|rcsb pdb:5J86|rcsb pdb:5J8M|rcsb pdb:5J8U|rcsb pdb:5J9X|rcsb pdb:4YKZ|rcsb pdb:5LNY|rcsb pdb:5LNZ|rcsb pdb:5LO0|refseq:NP_001017963.2|refseq:NP_005339.3|dip:DIP-27595N|uniprotkb:P07900(identity)|human orfeome collection:53186(identity)|entrezgene/locuslink:3320(identity) refseq:NP_001193658.1|refseq:NP_005456.1|refseq:NP_859029.1|refseq:XP_005273051.1|refseq:XP_005273052.1|dip:DIP-32584N|ensembl:ENSG00000117020(gene)|ensembl:ENSG00000275199(gene)|ensembl:ENST00000263826(transcript)|ensembl:ENST00000621586(transcript)|ensembl:ENST00000673466(transcript)|ensembl:ENST00000680118(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-211163|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034675|interpro:IPR039026|interpro:IPR039029|mint:Q9Y243|rcsb pdb:2X18|reactome:R-HSA-111447|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|uniprotkb:Q9Y243(identity)|human orfeome collection:56787(identity)|ddbj/embl/genbank:BC121154(identity)|entrezgene/locuslink:10000(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 rogid:pwxyw/nuFIUqnuBVKH3HNoNW7309606 intact-crc:0FDB8A4ADA5DB24D|rigid:EewV36lHwXNJf/sc1AqksXkVNAg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y243 uniprotkb:Q16543 intact:EBI-296115|uniprotkb:Q0VAA6|uniprotkb:Q5VTI1|uniprotkb:Q5VTI2|uniprotkb:Q96QV3|uniprotkb:Q9UFP5|ensembl:ENSP00000263826|ensembl:ENSP00000479081|ensembl:ENSP00000500582|ensembl:ENSP00000505276 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:akt3_human(display_long)|uniprotkb:AKT3(gene name)|psi-mi:AKT3(display_short)|uniprotkb:PKBG(gene name synonym)|uniprotkb:RAC-PK-gamma(gene name synonym)|uniprotkb:Protein kinase Akt-3(gene name synonym)|uniprotkb:Protein kinase B gamma(gene name synonym)|uniprotkb:STK-2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389391|imex:IM-22301-1536 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001193658.1|refseq:NP_005456.1|refseq:NP_859029.1|refseq:XP_005273051.1|refseq:XP_005273052.1|dip:DIP-32584N|ensembl:ENSG00000117020(gene)|ensembl:ENSG00000275199(gene)|ensembl:ENST00000263826(transcript)|ensembl:ENST00000621586(transcript)|ensembl:ENST00000673466(transcript)|ensembl:ENST00000680118(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-211163|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034675|interpro:IPR039026|interpro:IPR039029|mint:Q9Y243|rcsb pdb:2X18|reactome:R-HSA-111447|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|uniprotkb:Q9Y243(identity)|human orfeome collection:56787(identity)|ddbj/embl/genbank:BC121154(identity)|entrezgene/locuslink:10000(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, fig 7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pwxyw/nuFIUqnuBVKH3HNoNW7309606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:E84F552294F0EBFD|rigid:xlHK+jx8CWD3sOMBu5gyYtVthxo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y243 uniprotkb:Q96RS6 intact:EBI-296115|uniprotkb:Q0VAA6|uniprotkb:Q5VTI1|uniprotkb:Q5VTI2|uniprotkb:Q96QV3|uniprotkb:Q9UFP5|ensembl:ENSP00000263826|ensembl:ENSP00000479081|ensembl:ENSP00000500582|ensembl:ENSP00000505276 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:akt3_human(display_long)|uniprotkb:AKT3(gene name)|psi-mi:AKT3(display_short)|uniprotkb:PKBG(gene name synonym)|uniprotkb:RAC-PK-gamma(gene name synonym)|uniprotkb:Protein kinase Akt-3(gene name synonym)|uniprotkb:Protein kinase B gamma(gene name synonym)|uniprotkb:STK-2(gene name synonym) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389411|imex:IM-22301-1537 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001193658.1|refseq:NP_005456.1|refseq:NP_859029.1|refseq:XP_005273051.1|refseq:XP_005273052.1|dip:DIP-32584N|ensembl:ENSG00000117020(gene)|ensembl:ENSG00000275199(gene)|ensembl:ENST00000263826(transcript)|ensembl:ENST00000621586(transcript)|ensembl:ENST00000673466(transcript)|ensembl:ENST00000680118(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-211163|reactome:R-HSA-389357|reactome:R-HSA-389513|reactome:R-HSA-392451|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-69202|reactome:R-HSA-69656|reactome:R-HSA-8876198|reactome:R-HSA-8941332|reactome:R-HSA-8948751|reactome:R-HSA-9607240|reactome:R-HSA-9614399|reactome:R-HSA-9634638|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034675|interpro:IPR039026|interpro:IPR039029|mint:Q9Y243|rcsb pdb:2X18|reactome:R-HSA-111447|reactome:R-HSA-1257604|reactome:R-HSA-1358803|reactome:R-HSA-198323|reactome:R-HSA-198693|reactome:R-HSA-199418|uniprotkb:Q9Y243(identity)|human orfeome collection:56787(identity)|ddbj/embl/genbank:BC121154(identity)|entrezgene/locuslink:10000(identity) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pwxyw/nuFIUqnuBVKH3HNoNW7309606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:22DE916784B0E442|rigid:+O6Qb8rCJ//wiB2dBRf6NoBZtTA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9Y285 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-725361|uniprotkb:Q9NSD8|uniprotkb:Q9Y4W8|uniprotkb:B4E363|ensembl:ENSP00000320309 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:syfa_human(display_long)|uniprotkb:CML33(gene name synonym)|uniprotkb:FARSA(gene name)|psi-mi:FARSA(display_short)|uniprotkb:FARS(gene name synonym)|uniprotkb:FARSLA(gene name synonym)|uniprotkb:FARSL(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389430|imex:IM-22301-1538 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_004452.1|ensembl:ENSG00000179115(gene)|ensembl:ENST00000314606(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q9Y285|rcsb pdb:3L4G|reactome:R-HSA-379716|dip:DIP-53610N|uniprotkb:Q9Y285(identity)|human orfeome collection:4458(identity)|entrezgene/locuslink:2193(identity)|ddbj/embl/genbank:BC006495(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:FpOCk4Mzmsb2CnIUwUKg5nRg7/U9606 intact-crc:43BC8EDB7B883F9C|rigid:UdXt0Du4e5IQp010TRZiDhMBNZU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13200 uniprotkb:Q9Y285 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 intact:EBI-725361|uniprotkb:Q9NSD8|uniprotkb:Q9Y4W8|uniprotkb:B4E363|ensembl:ENSP00000320309 psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:syfa_human(display_long)|uniprotkb:CML33(gene name synonym)|uniprotkb:FARSA(gene name)|psi-mi:FARSA(display_short)|uniprotkb:FARS(gene name synonym)|uniprotkb:FARSLA(gene name synonym)|uniprotkb:FARSL(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389452|imex:IM-22301-1539 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N|uniprotkb:Q13200(identity)|human orfeome collection:3990(identity)|entrezgene/locuslink:5708(identity)|ddbj/embl/genbank:BC002368(identity) refseq:NP_004452.1|ensembl:ENSG00000179115(gene)|ensembl:ENST00000314606(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q9Y285|rcsb pdb:3L4G|reactome:R-HSA-379716|dip:DIP-53610N|uniprotkb:Q9Y285(identity)|human orfeome collection:4458(identity)|entrezgene/locuslink:2193(identity)|ddbj/embl/genbank:BC006495(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rogid:FpOCk4Mzmsb2CnIUwUKg5nRg7/U9606 intact-crc:E0D916C055B0B13B|rigid:Oyp3kzlDRU3sqP5gPPzzvOKHHVY false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y2H1 uniprotkb:Q16543 intact:EBI-991501|uniprotkb:Q8TBX7|uniprotkb:A8K4U0|uniprotkb:B4E3J8|ensembl:ENSP00000373684 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:st38l_human(display_long)|uniprotkb:NDR2 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 2(gene name synonym)|uniprotkb:STK38L(gene name)|psi-mi:STK38L(display_short)|uniprotkb:KIAA0965(gene name synonym)|uniprotkb:NDR2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389474|imex:IM-22301-1540 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006719121.1|ensembl:ENSG00000211455(gene)|ensembl:ENST00000389032(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003779"(actin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051128"(regulation of cellular component organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005524"(ATP binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q9Y2H1|rcsb pdb:5XQZ|refseq:NP_055815.1|refseq:XP_011518915.1|refseq:XP_016874525.1|uniprotkb:Q9Y2H1(identity)|ddbj/embl/genbank:BC028603(identity)|entrezgene/locuslink:23012(identity)|human orfeome collection:1751(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lKXWdkeLMD/YCxa1oQz9k0aoW3I9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:00A74669C483533F|rigid:z6TKDnG5aumnwd8f1xuRC5S4K58 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9Y2I1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2688731|uniprotkb:Q6PIB4|uniprotkb:Q9UEU4|uniprotkb:Q7L8M3|uniprotkb:Q6PGP3|uniprotkb:Q9UFW3|uniprotkb:Q7Z2X6|uniprotkb:Q9UES6|uniprotkb:C9J245|ensembl:ENSP00000339958|ensembl:ENSP00000418232 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:nisch_human(display_long)|uniprotkb:IRAS(gene name synonym)|uniprotkb:KIAA0975(gene name synonym)|uniprotkb:Imidazoline receptor 1(gene name synonym)|uniprotkb:Imidazoline receptor antisera-selected protein(gene name synonym)|uniprotkb:Imidazoline-1 receptor(gene name synonym)|uniprotkb:Imidazoline-1 receptor candidate protein(gene name synonym)|uniprotkb:NISCH(gene name)|psi-mi:NISCH(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389494|imex:IM-22301-1541 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_009115.2|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048243"(norepinephrine secretion)|go:"GO:0055037"(recycling endosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001683(Phox-like)|interpro:IPR032675|interpro:IPR036871|interpro:IPR037904|mint:Q9Y2I1|rcsb pdb:3P0C|reactome:R-HSA-9013149|reactome:R-HSA-9696264|reactome:R-HSA-9696270|ensembl:ENSG00000010322(gene)|ensembl:ENST00000345716(transcript)|ensembl:ENST00000479054(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|refseq:NP_001263222.1|refseq:NP_001263223.1|uniprotkb:Q9Y2I1(identity)|entrezgene/locuslink:11188(identity)|human orfeome collection:12011(identity)|ddbj/embl/genbank:BC056900(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:GuBgG6MUrD5p1hIhGGmrtCjT0jQ9606 intact-crc:3AD5D3CF91DFD09A|rigid:ZE3q3ru7p6eBo2aynbZ4vLZDqCA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y2I1 uniprotkb:Q96BE0 intact:EBI-2688731|uniprotkb:Q6PIB4|uniprotkb:Q9UEU4|uniprotkb:Q7L8M3|uniprotkb:Q6PGP3|uniprotkb:Q9UFW3|uniprotkb:Q7Z2X6|uniprotkb:Q9UES6|uniprotkb:C9J245|ensembl:ENSP00000339958|ensembl:ENSP00000418232 intact:EBI-9356686 psi-mi:nisch_human(display_long)|uniprotkb:IRAS(gene name synonym)|uniprotkb:KIAA0975(gene name synonym)|uniprotkb:Imidazoline receptor 1(gene name synonym)|uniprotkb:Imidazoline receptor antisera-selected protein(gene name synonym)|uniprotkb:Imidazoline-1 receptor(gene name synonym)|uniprotkb:Imidazoline-1 receptor candidate protein(gene name synonym)|uniprotkb:NISCH(gene name)|psi-mi:NISCH(display_short) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389513|imex:IM-22301-1542 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009115.2|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048243"(norepinephrine secretion)|go:"GO:0055037"(recycling endosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001683(Phox-like)|interpro:IPR032675|interpro:IPR036871|interpro:IPR037904|mint:Q9Y2I1|rcsb pdb:3P0C|reactome:R-HSA-9013149|reactome:R-HSA-9696264|reactome:R-HSA-9696270|ensembl:ENSG00000010322(gene)|ensembl:ENST00000345716(transcript)|ensembl:ENST00000479054(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|refseq:NP_001263222.1|refseq:NP_001263223.1|uniprotkb:Q9Y2I1(identity)|entrezgene/locuslink:11188(identity)|human orfeome collection:12011(identity)|ddbj/embl/genbank:BC056900(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GuBgG6MUrD5p1hIhGGmrtCjT0jQ9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:52EA34913E4785CF|rigid:bM45eYop6Lmsmek79jso55yOFYE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y312 uniprotkb:Q13451 intact:EBI-748721|uniprotkb:Q9H4F9|uniprotkb:Q9P1P3|uniprotkb:Q9UFK9|uniprotkb:E1P5S7|ensembl:ENSP00000313674|ensembl:ENSP00000363043|ensembl:ENSP00000505061|ensembl:ENSP00000505295|ensembl:ENSP00000505405|ensembl:ENSP00000506185|ensembl:ENSP00000506354 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:aar2_human(display_long)|uniprotkb:AAR2(gene name)|psi-mi:AAR2(display_short)|uniprotkb:AAR2 splicing factor homolog(gene name synonym)|uniprotkb:C20orf4(gene name synonym)|uniprotkb:CGI-23(orf name)|uniprotkb:PRO0225(orf name) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389535|imex:IM-22301-1543 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056326.2|refseq:NP_001258803.1|refseq:XP_006723833.1|refseq:XP_011527065.1|refseq:XP_011527064.1|ensembl:ENSG00000131043(gene)|ensembl:ENST00000320849(transcript)|ensembl:ENST00000373932(transcript)|ensembl:ENST00000679667(transcript)|ensembl:ENST00000680247(transcript)|ensembl:ENST00000680639(transcript)|ensembl:ENST00000680811(transcript)|ensembl:ENST00000680933(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|interpro:IPR007946(AAR2)|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516|mint:Q9Y312|uniprotkb:Q9Y312(identity)|entrezgene/locuslink:25980(identity)|human orfeome collection:3691(identity)|ddbj/embl/genbank:BC001751(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvbhGa01cuYd3fN8vbbXdzS0mSg9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:72D8D4ABC50C0C9A|rigid:FnzNET0sjYFBnV31LZn7jmus1Xc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y312 uniprotkb:Q15773 intact:EBI-748721|uniprotkb:Q9H4F9|uniprotkb:Q9P1P3|uniprotkb:Q9UFK9|uniprotkb:E1P5S7|ensembl:ENSP00000313674|ensembl:ENSP00000363043|ensembl:ENSP00000505061|ensembl:ENSP00000505295|ensembl:ENSP00000505405|ensembl:ENSP00000506185|ensembl:ENSP00000506354 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:aar2_human(display_long)|uniprotkb:AAR2(gene name)|psi-mi:AAR2(display_short)|uniprotkb:AAR2 splicing factor homolog(gene name synonym)|uniprotkb:C20orf4(gene name synonym)|uniprotkb:CGI-23(orf name)|uniprotkb:PRO0225(orf name) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389554|imex:IM-22301-1544 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056326.2|refseq:NP_001258803.1|refseq:XP_006723833.1|refseq:XP_011527065.1|refseq:XP_011527064.1|ensembl:ENSG00000131043(gene)|ensembl:ENST00000320849(transcript)|ensembl:ENST00000373932(transcript)|ensembl:ENST00000679667(transcript)|ensembl:ENST00000680247(transcript)|ensembl:ENST00000680639(transcript)|ensembl:ENST00000680811(transcript)|ensembl:ENST00000680933(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|interpro:IPR007946(AAR2)|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516|mint:Q9Y312|uniprotkb:Q9Y312(identity)|entrezgene/locuslink:25980(identity)|human orfeome collection:3691(identity)|ddbj/embl/genbank:BC001751(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:mvbhGa01cuYd3fN8vbbXdzS0mSg9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:6C6B8B2103A02A16|rigid:sd0uEO9S1t+xt4UlmexbHlrBvww false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y312 uniprotkb:Q9UIM3 intact:EBI-748721|uniprotkb:Q9H4F9|uniprotkb:Q9P1P3|uniprotkb:Q9UFK9|uniprotkb:E1P5S7|ensembl:ENSP00000313674|ensembl:ENSP00000363043|ensembl:ENSP00000505061|ensembl:ENSP00000505295|ensembl:ENSP00000505405|ensembl:ENSP00000506185|ensembl:ENSP00000506354 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:aar2_human(display_long)|uniprotkb:AAR2(gene name)|psi-mi:AAR2(display_short)|uniprotkb:AAR2 splicing factor homolog(gene name synonym)|uniprotkb:C20orf4(gene name synonym)|uniprotkb:CGI-23(orf name)|uniprotkb:PRO0225(orf name) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389576|imex:IM-22301-1545 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056326.2|refseq:NP_001258803.1|refseq:XP_006723833.1|refseq:XP_011527065.1|refseq:XP_011527064.1|ensembl:ENSG00000131043(gene)|ensembl:ENST00000320849(transcript)|ensembl:ENST00000373932(transcript)|ensembl:ENST00000679667(transcript)|ensembl:ENST00000680247(transcript)|ensembl:ENST00000680639(transcript)|ensembl:ENST00000680811(transcript)|ensembl:ENST00000680933(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|interpro:IPR007946(AAR2)|interpro:IPR033647|interpro:IPR033648|interpro:IPR038514|interpro:IPR038516|mint:Q9Y312|uniprotkb:Q9Y312(identity)|entrezgene/locuslink:25980(identity)|human orfeome collection:3691(identity)|ddbj/embl/genbank:BC001751(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvbhGa01cuYd3fN8vbbXdzS0mSg9606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:C102BF279E81E87F|rigid:VF702VlC3RctKCrgClniOt9OqXU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43765 uniprotkb:Q9Y3F4 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-727414|uniprotkb:Q9UQC8|uniprotkb:Q9NTK0|uniprotkb:Q5TZT4|intact:EBI-6190807|uniprotkb:B4DNJ6|uniprotkb:B2R5S5|ensembl:ENSP00000392270 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:strap_human(display_long)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:WD-40 repeat protein PT-WD(gene name synonym)|uniprotkb:MAP activator with WD repeats(gene name synonym)|uniprotkb:STRAP(gene name)|psi-mi:STRAP(display_short)|uniprotkb:MAWD(gene name synonym)|uniprotkb:UNRIP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389595|imex:IM-22301-1546 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|human orfeome collection:3952(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_009109.3|ensembl:ENSG00000023734(gene)|ensembl:ENST00000419869(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Y3F4|reactome:R-HSA-2173788|uniprotkb:Q9Y3F4(identity)|human orfeome collection:35(identity)|ddbj/embl/genbank:BC000162(identity)|entrezgene/locuslink:11171(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:/IqZt6BHPxD3S/THUZry4+QUvCE9606 intact-crc:7C1770B3EF3EBA2F|rigid:pA+gW51Cyqb44Nmlt87mnkF3Ff8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y458 uniprotkb:Q96BE0 intact:EBI-6427217|ensembl:ENSP00000362390|ensembl:ENSP00000362393|ensembl:ENSP00000479825|ensembl:ENSP00000487295|uniprotkb:Q5JZ06|uniprotkb:Q9HBF1|uniprotkb:Q96LC0 intact:EBI-9356686 psi-mi:tbx22_human(display_long)|uniprotkb:TBX22(gene name)|psi-mi:TBX22(display_short)|uniprotkb:TBOX22(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389617|imex:IM-22301-1547 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001290404.1|refseq:XP_011529274.1|ensembl:ENSG00000122145(gene)|ensembl:ENSG00000277800(gene)|ensembl:ENST00000373294(transcript)|ensembl:ENST00000373296(transcript)|ensembl:ENST00000619509(transcript)|ensembl:ENST00000628957(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|refseq:NP_001103348.1|refseq:NP_001103349.1|refseq:NP_058650.1|uniprotkb:Q9Y458(identity)|ddbj/embl/genbank:BC014194(identity)|entrezgene/locuslink:50945(identity)|human orfeome collection:7301(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Qi7FDA+l3+qb0J+BQvPCJsvHDsY9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:0A308E57CB647FF3|rigid:0DBtZhDJvF0aIpvDqRGgNWjB/t0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y458 uniprotkb:P31948 intact:EBI-6427217|ensembl:ENSP00000362390|ensembl:ENSP00000362393|ensembl:ENSP00000479825|ensembl:ENSP00000487295|uniprotkb:Q5JZ06|uniprotkb:Q9HBF1|uniprotkb:Q96LC0 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:tbx22_human(display_long)|uniprotkb:TBX22(gene name)|psi-mi:TBX22(display_short)|uniprotkb:TBOX22(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389639|imex:IM-22301-1548 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001290404.1|refseq:XP_011529274.1|ensembl:ENSG00000122145(gene)|ensembl:ENSG00000277800(gene)|ensembl:ENST00000373294(transcript)|ensembl:ENST00000373296(transcript)|ensembl:ENST00000619509(transcript)|ensembl:ENST00000628957(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0001947"(heart looping)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|refseq:NP_001103348.1|refseq:NP_001103349.1|refseq:NP_058650.1|uniprotkb:Q9Y458(identity)|ddbj/embl/genbank:BC014194(identity)|entrezgene/locuslink:50945(identity)|human orfeome collection:7301(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Qi7FDA+l3+qb0J+BQvPCJsvHDsY9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:B053A7EAB73702A8|rigid:aUmO0TStMx96Xv9+UN6fCnI7qH4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:P58340 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-721328|intact:EBI-767466|uniprotkb:E9PEU9|uniprotkb:Q2TLE5|uniprotkb:Q8N8F8|uniprotkb:Q96MH1|uniprotkb:Q2TLE3|ensembl:ENSP00000348157 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:mlf1_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 1(gene name synonym)|uniprotkb:MLF1(gene name)|psi-mi:MLF1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389658|imex:IM-22301-1549 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) refseq:NP_071888.1|refseq:NP_001182361.1|refseq:NP_001182362.1|refseq:NP_001182363.1|refseq:XP_011511154.1|refseq:NP_001123628.1|refseq:NP_001123629.1|ensembl:ENSP00000348157|ensembl:ENST00000359117|ensembl:ENSP00000352025|ensembl:ENST00000392822|ensembl:ENSP00000376568|ensembl:ENST00000469452|ensembl:ENSP00000418595|ensembl:ENST00000471745|ensembl:ENSP00000420134|ensembl:ENST00000477042|ensembl:ENSP00000419637|ensembl:ENST00000478894|ensembl:ENSP00000417777|ensembl:ENST00000482628|ensembl:ENSP00000417141|ensembl:ENST00000484955|ensembl:ENSP00000417835|ensembl:ENST00000618075|ensembl:ENSP00000484169|ensembl:ENST00000651874|ensembl:ENSP00000498363|refseq:XP_011511155.1|refseq:XP_005247537.1|ensembl:ENSG00000178053(gene)|ensembl:ENST00000355893(transcript)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR019376|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6Y8E|uniprotkb:P58340(identity)|ddbj/embl/genbank:BC007045(identity)|entrezgene/locuslink:4291(identity)|human orfeome collection:5516(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:czY64xaocTjgRFAtZU19jvH4MIo9606 intact-crc:7FE5658C9194BE35|rigid:a/yxlOEZFjGBYfddK5Wm71VBfxI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:Q6PK50 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-9356629 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:q6pk50_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389680|imex:IM-22301-1550 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) interpro:IPR036890|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_001258901.1|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q6PK50(identity)|entrezgene/locuslink:3326(identity)|human orfeome collection:4262(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|antagonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:vfuyuFWmhK9DZefAlEp5RFkxPhw9606 intact-crc:D1A7BDE33E46FFF4|rigid:cNvKZgSTHfSxTL7S+EFIxyZxLbM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:Q53FC7 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-9356749 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:q53fc7_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389702|imex:IM-22301-1551 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005524"(ATP binding)|uniprotkb:Q53FC7(identity)|ddbj/embl/genbank:BC035665(identity)|human orfeome collection:10186(identity)|entrezgene/locuslink:3310(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:QGFrceyE0g88j+cjhUmOswPeXDA9606 intact-crc:E5AB83FBFBCE90D9|rigid:jBI6QrKMODxcLOfqJpcdRUJ36zc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:Q9Y266 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389724|imex:IM-22301-1552 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:911A18389ADC2AE0|rigid:T6IBSPLJpKfeQap8H/A+YPTyKaY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:Q8IVD9 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389743|imex:IM-22301-1553 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:A1CCAB658918DB80|rigid:OTulfnGokCQeGGwu+fADsO2IiCg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:B4DYC6 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-9357028 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389762|imex:IM-22301-1554 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:8210205273D26386|rigid:MFhlRfk2UpmDu1Zirq810Otczr4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y577 uniprotkb:Q96BE0 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 intact:EBI-9356686 psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:q96be0_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389782|imex:IM-22301-1555 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 intact-crc:06AC0F44E0315302|rigid:eMrTk23dQXvjRjYZ/Ebd1qT8ZvM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HB71 uniprotkb:Q9Y577 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389804|imex:IM-22301-1556 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 intact-crc:DAAE1C64006DC962|rigid:PWOyvFzvLwKwjeVysOVmCpL0228 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9Y577 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-743894|uniprotkb:B4DVJ2|uniprotkb:Q5VST8|ensembl:ENSP00000295033|ensembl:ENSP00000355658|ensembl:ENSP00000355659|ensembl:ENSP00000493891|ensembl:ENSP00000495842|ensembl:ENSP00000496098 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:tri17_human(display_long)|uniprotkb:Testis RING finger protein(gene name synonym)|uniprotkb:RING finger protein 16(gene name synonym)|uniprotkb:TRIM17(gene name)|psi-mi:TRIM17(display_short)|uniprotkb:RBCC(gene name synonym)|uniprotkb:RNF16(gene name synonym)|uniprotkb:TERF(gene name synonym)|uniprotkb:Tripartite motif-containing protein 17(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM17(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389823|imex:IM-22301-1557 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000162931(gene)|ensembl:ENSG00000285344(gene)|refseq:NP_001020111.1|refseq:NP_001128327.1|refseq:NP_057186.1|refseq:XP_011542511.1|refseq:XP_011542512.1|refseq:XP_006711842.1|ensembl:ENST00000295033(transcript)|ensembl:ENST00000366697(transcript)|ensembl:ENST00000366698(transcript)|ensembl:ENST00000645562(transcript)|ensembl:ENST00000645958(transcript)|ensembl:ENST00000647385(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0045087"(innate immune response)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR027370|interpro:IPR032918|interpro:IPR035687|interpro:IPR043136|reactome:R-HSA-877300|uniprotkb:Q9Y577(identity)|entrezgene/locuslink:51127(identity)|human orfeome collection:9881(identity)|ddbj/embl/genbank:BC033788(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:pXiCDkeNMtq9icQduH4MSCM6vSQ9606 intact-crc:1476BA6E25F8CD0D|rigid:49aS/Tw0wJ+0ftDRNOUI41sJ1BE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15773 uniprotkb:Q9Y678 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389845|imex:IM-22301-1558 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:A8K1F4(identity)|ddbj/embl/genbank:BC000898(identity)|entrezgene/locuslink:8079(identity)|human orfeome collection:10(identity) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|human orfeome collection:12314(identity)|ddbj/embl/genbank:BC066650(identity)|entrezgene/locuslink:22820(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/04/24 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:F5EBFEAE25F32255|rigid:rz5oybp6bDAz8TfKNn7lPlJorp0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96BE0 uniprotkb:Q9Y678 intact:EBI-9356686 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:q96be0_human(display_long) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389867|imex:IM-22301-1559 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|human orfeome collection:289(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|human orfeome collection:12314(identity)|ddbj/embl/genbank:BC066650(identity)|entrezgene/locuslink:22820(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|agonist:Ganetespib|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:53BEB417E3C456A6|rigid:tVjDYVwigB84GoB6QwkGgD9ioRM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y678 uniprotkb:Q9HB71 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389889|imex:IM-22301-1560 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|human orfeome collection:12314(identity)|ddbj/embl/genbank:BC066650(identity)|entrezgene/locuslink:22820(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:9467122054EDE082|rigid:qR+vGWd3Qst72hyoZKskFSfWOtg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RS6 uniprotkb:Q9Y678 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389908|imex:IM-22301-1561 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|human orfeome collection:12314(identity)|ddbj/embl/genbank:BC066650(identity)|entrezgene/locuslink:22820(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:DD0F105C4FC35E21|rigid:zWQGvFEpVan4VR18mx9+oMrMSDw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6-2 uniprotkb:Q9Y678 intact:EBI-9357295|ensembl:ENSP00000353355 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:q9bte6-2(display_long)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9389927|imex:IM-22301-1562 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2796199(isoform-parent)|ensembl:ENSG00000108825(gene)|ensembl:ENST00000360221(transcript)|uniprotkb:Q9BTE6-2(isoform-parent)|uniprotkb:Q9BTE6-2(identity)|entrezgene/locuslink:80755(identity)|human orfeome collection:5376(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|human orfeome collection:12314(identity)|ddbj/embl/genbank:BC066650(identity)|entrezgene/locuslink:22820(identity) psi-mi:"MI:0469"(intact) isoform-comment:Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available. - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mjw6nADiBqU/Gb+LaF2ZWUvpIWY9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:7CB871960D58A79E|rigid:2hhZ/J6xdPSSFv0p26TT2vZ3i4o false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI6 uniprotkb:O95429 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395878|imex:IM-22301-1615 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336 - - - figure legend:Supplementary fig 3G|caution:Figure legend states that this interaction is in supplementary figure 3G, but in the figure the data appears labeled as supplementary 3H.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:BDF8440DB99F2290|rigid:wwAmNCMUXebUclGV58cip/HCveA false renilla luciferase protein tag:c-c mutation disrupting interaction:424-424|flag tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:A6NCF5 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9476839|ensembl:ENSP00000341549 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh33_human(display_long)|uniprotkb:KLHL33(gene name)|psi-mi:KLHL33(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482674|imex:IM-22301-1631 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001103467.2|ensembl:ENSG00000185271(gene)|ensembl:ENST00000344581(transcript)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030609|uniprotkb:A6NCF5(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:QlhIqDSAywRSdrqOjlSebubCRpQ9606 intact-crc:E8623D88B61F0E3A|rigid:RkPAdLeetjJ93XYJ1UwgMoW+aY4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A4D1P6 uniprotkb:Q9Y266 intact:EBI-718046|uniprotkb:A6NK54|uniprotkb:C9JMI4|uniprotkb:Q6FI65|uniprotkb:Q6MZQ1|uniprotkb:Q6P4I1|uniprotkb:Q96AE5|uniprotkb:Q96G63|uniprotkb:Q9H062|uniprotkb:Q9H9B6|uniprotkb:Q9NVG7|uniprotkb:Q9NZY6|ensembl:ENSP00000346466 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:wdr91_human(display_long)|uniprotkb:WDR91(gene name)|psi-mi:WDR91(display_short)|uniprotkb:HSPC049(orf name) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482659|imex:IM-22301-1630 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054868.3|ensembl:ENSG00000105875(gene)|ensembl:ENST00000354475(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:1903362"(regulation of cellular protein catabolic process)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039724|rcsb pdb:6VYC|reactome:R-HSA-9013148|uniprotkb:A4D1P6(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Lcc2+uMzFIgd+WP1QGrWhAf4Bgw9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:4BC2DC2B02958358|rigid:AeEAuVH+R/Aoq59W1yIWHUiT8Ro false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A2RRH5 uniprotkb:B4DYC6 intact:EBI-9476803|uniprotkb:C9JGV0|uniprotkb:Q5T066|uniprotkb:A5PLM8 intact:EBI-9357028 psi-mi:wdr27_human(display_long)|uniprotkb:WDR27(gene name)|psi-mi:WDR27(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482643|imex:IM-22301-1629 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_001189479.1|refseq:NP_872358.4|interpro:IPR042411|go:"GO:0005654"(nucleoplasm)|uniprotkb:A2RRH5(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:aeCo/4VTjSHz9pRx+rosC38yku49606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:A74F3336CD122B58|rigid:ZnKDRpptqGhX6NzNrMrHDRwB8jo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:O00628 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-5238811|uniprotkb:C0H5X6|ensembl:ENSP00000315680 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:pex7_human(display_long)|uniprotkb:PEX7(gene name)|psi-mi:PEX7(display_short)|uniprotkb:PTS2R(gene name synonym)|uniprotkb:Peroxin-7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482720|imex:IM-22301-1634 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000112357(gene)|ensembl:ENST00000318471(transcript)|go:"GO:0005053"(peroxisome matrix targeting signal-2 binding)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR044536|mint:O00628|reactome:R-HSA-9033241|go:"GO:0005777"(peroxisome)|refseq:NP_000279.1|uniprotkb:O00628(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:Ls4aZb7kBzhLXYTfWvT+7BP4v/U9606 intact-crc:9235F9D69F979CCF|rigid:GloQyAwzlW8k2+ndGL15e/f2D2I false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00423 uniprotkb:Q9Y266 intact:EBI-751327|uniprotkb:Q86U15|uniprotkb:Q8N536|uniprotkb:Q8N5C4|uniprotkb:Q8WWL6|ensembl:ENSP00000262233 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:emal1_human(display_long)|uniprotkb:EML1(gene name)|psi-mi:EML1(display_short)|uniprotkb:EMAP1(gene name synonym)|uniprotkb:EMAPL(gene name synonym)|uniprotkb:EMAPL1(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482705|imex:IM-22301-1633 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008707.1|refseq:NP_004425.2|ensembl:ENSG00000066629(gene)|ensembl:ENST00000262233(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:O00423|rcsb pdb:4CI8|uniprotkb:O00423(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hfGdCoFa3Miii6W/ozQuZ2cFiHs9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:F37F3C6C4123BA46|rigid:wsQF6vtW0yF3wqbAsk32T66ipTc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q96DD0 intact:EBI-9357028 intact:EBI-9539130|uniprotkb:B3KUD2|uniprotkb:D3DT56|uniprotkb:Q5VVK7|ensembl:ENSP00000344470|ensembl:ENSP00000359156 psi-mi:b4dyc6_human(display_long) psi-mi:lrc39_human(display_long)|uniprotkb:Myosin-interacting M-band-associated stress-responsive protein(gene name synonym)|uniprotkb:UNQ6500/PRO21368(orf name)|uniprotkb:LRRC39(gene name)|psi-mi:LRRC39(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482689|imex:IM-22301-1632 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001243314.1|refseq:NP_001243315.1|refseq:NP_001243316.1|refseq:NP_653221.1|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0031430"(M band)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|ensembl:ENST00000370137(transcript)|ensembl:ENSG00000122477(gene)|ensembl:ENST00000342895(transcript)|uniprotkb:LRRC39(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:9i02yidsHo98PX+u7NWDFa+/2ao9606 intact-crc:FD07FD18E94D2F9A|rigid:hs1iu+NjA0Dg+a8r6TWp0QRp/po false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60938 uniprotkb:Q16543 intact:EBI-7969075|intact:MINT-7970761|ensembl:ENSP00000266719 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:kera_human(display_long)|uniprotkb:KERA(gene name)|psi-mi:KERA(display_short)|uniprotkb:SLRR2B(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan keratocan(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482751|imex:IM-22301-1636 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008966.1|ensembl:ENSG00000139330(gene)|ensembl:ENST00000266719(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007601"(visual perception)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050896"(response to stimulus)|go:"GO:0061303"(cornea development in camera-type eye)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244|uniprotkb:O60938(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) comment:mint - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8ruCw1Alp/Cm8rKIKnZ5aW8Aalk9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:91CB1C26288D70FA|rigid:y+WaBWzGHVPJoqt0pU8UGNCSoXQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:O75094 intact:EBI-9357028 intact:EBI-2622593|uniprotkb:O95804|uniprotkb:Q9UFH5|uniprotkb:A6H8U9|ensembl:ENSP00000430333|uniprotkb:J3KNP3 psi-mi:b4dyc6_human(display_long) psi-mi:slit3_human(display_long)|uniprotkb:KIAA0814(gene name synonym)|uniprotkb:MEGF5(gene name synonym)|uniprotkb:SLIL2(gene name synonym)|uniprotkb:Multiple epidermal growth factor-like domains protein 5(gene name synonym)|uniprotkb:UNQ691/PRO1336(orf name)|uniprotkb:SLIT3(gene name)|psi-mi:SLIT3(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482782|imex:IM-22301-1638 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_003053.1|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428542|ensembl:ENSG00000184347(gene)|ensembl:ENST00000519560(transcript)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|refseq:NP_001258875.1|uniprotkb:O75094(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:Qazwnc23w/tZ8NsF8G3ZLSEF1SE9606 intact-crc:8DFF7EEEF7874514|rigid:46a4d/5TJ+6gjFD+qhPzMKuJ5g8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75037 uniprotkb:Q9Y266 intact:EBI-6166435|ensembl:ENSP00000411831|uniprotkb:Q5T4J3|uniprotkb:B2RP62|uniprotkb:B7ZMI0|intact:EBI-11017531 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:ki21b_human(display_long)|uniprotkb:KIF21B(gene name)|psi-mi:KIF21B(display_short)|uniprotkb:KIAA0449(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482767|imex:IM-22301-1637 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000116852(gene)|ensembl:ENST00000422435(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990939"|interpro:IPR001680(WD40 repeat)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR019821|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|reactome:R-HSA-6811434|reactome:R-HSA-983189|interpro:IPR027417|refseq:NP_001239029.1|refseq:NP_001239031.1|refseq:NP_001239032.1|refseq:NP_060066.2|uniprotkb:O75037(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VQsDEkUYcMpRqaHJe3J4mcQhyiQ9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:C562309BF4631BD2|rigid:zP2gutDL8HJCswaC939Pz4sZwok false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43155 uniprotkb:B4DYC6 intact:EBI-8042406|uniprotkb:B7ZLP3|intact:MINT-1778460|uniprotkb:A0AV84|ensembl:ENSP00000332879|ensembl:ENSP00000451050|ensembl:ENSP00000507088|ensembl:ENSP00000507815 intact:EBI-9357028 psi-mi:flrt2_human(display_long)|uniprotkb:FLRT2(gene name)|psi-mi:FLRT2(display_short)|uniprotkb:KIAA0405(gene name synonym)|uniprotkb:UNQ232/PRO265(orf name)|uniprotkb:Fibronectin-like domain-containing leucine-rich transmembrane protein 2(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482735|imex:IM-22301-1635 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011534913.1|refseq:NP_001333072.1|refseq:NP_001333073.1|refseq:NP_001333074.1|refseq:NP_001333075.1|refseq:XP_005267547.1|refseq:NP_037363.1|refseq:XP_016876618.1|refseq:XP_016876619.1|refseq:XP_016876620.1|refseq:XP_016876621.1|refseq:XP_016876622.1|refseq:XP_016876623.1|refseq:XP_016876624.1|ensembl:ENSG00000185070(gene)|ensembl:ENST00000330753(transcript)|ensembl:ENST00000554746(transcript)|ensembl:ENST00000682132(transcript)|ensembl:ENST00000683129(transcript)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061343"(cell adhesion involved in heart morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071711"(basement membrane organization)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032675|interpro:IPR036116|reactome:R-HSA-5654687|uniprotkb:O43155(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) comment:mint|function:May have a function in cell adhesion and/or receptor signaling - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:NBhDy6sgaISgELnJvaq0W4ZtgBI9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:2B69C59896165C6B|rigid:xRHFl0rUDhay/7ieqSRaXqY0VTg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P20594 uniprotkb:Q16543 intact:EBI-6424644|ensembl:ENSP00000341083|uniprotkb:Q5TCV2|uniprotkb:B0ZBF2|uniprotkb:Q9UQ50|uniprotkb:B0ZBF3|uniprotkb:D3DRP3|uniprotkb:Q8TA93|uniprotkb:Q4VAK7|uniprotkb:O60871|uniprotkb:D3DRP4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:anprb_human(display_long)|uniprotkb:NPR2(gene name)|psi-mi:NPR2(display_short)|uniprotkb:ANPRB(gene name synonym)|uniprotkb:Atrial natriuretic peptide receptor type B(gene name synonym)|uniprotkb:Guanylate cyclase B(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482864|imex:IM-22301-1643 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000159899(gene)|ensembl:ENST00000342694(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001653"(peptide receptor activity)|go:"GO:0004383"(guanylate cyclase activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0016941"(natriuretic peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0022414"(reproductive process)|go:"GO:0042562"(hormone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0060348"(bone development)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1900194"(negative regulation of oocyte maturation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001054(Adenylyl cyclase class-3/4/guanylyl cyclase)|interpro:IPR001170(Natriuretic peptide receptor, N-terminal)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR018297|interpro:IPR028082|interpro:IPR029787|reactome:R-HSA-5578768|refseq:NP_003986.2|uniprotkb:P20594(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bO6nX36fNvd/Ur8A1/8yIARootE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:1CC65C10636AFAEF|rigid:FEYYNSCjzIC6hiWvWg2rxqyQFUY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P16591 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482848|imex:IM-22301-1642 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|uniprotkb:P16591(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606 intact-crc:A9A04BD31DB7BBC4|rigid:2KWcMB7P9NwEMp6YP2rb8qNRh/c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06241 uniprotkb:Q16543 intact:EBI-515315|uniprotkb:Q16248|uniprotkb:Q5R3A6|uniprotkb:Q5R3A7|uniprotkb:Q8N5D7|uniprotkb:B5BU57|intact:EBI-2561531|uniprotkb:E1P557|uniprotkb:H0UI48|ensembl:ENSP00000346671|ensembl:ENSP00000357656 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fyn_human(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482832|imex:IM-22301-1641 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005266947.1|refseq:XP_005266949.1|refseq:NP_002028.1|refseq:NP_694592.1|refseq:NP_694593.1|refseq:XP_016866139.1|refseq:XP_016866140.1|refseq:XP_016866141.1|refseq:XP_016866142.1|refseq:XP_016866143.1|dip:DIP-33876N|ensembl:ENSG00000010810(gene)|ensembl:ENST00000354650(transcript)|ensembl:ENST00000368667(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001764"(neuron migration)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0003015"(heart process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007612"(learning)|go:"GO:0007631"(feeding behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|interpro:IPR036028|interpro:IPR036860|mint:P06241|rcsb pdb:1A0N|rcsb pdb:1AOT|rcsb pdb:1AOU|rcsb pdb:1AVZ|rcsb pdb:1AZG|rcsb pdb:1EFN|rcsb pdb:1FYN|rcsb pdb:1G83|rcsb pdb:1M27|rcsb pdb:1NYF|rcsb pdb:1NYG|rcsb pdb:1SHF|rcsb pdb:1ZBJ|rcsb pdb:2DQ7|rcsb pdb:2MQI|rcsb pdb:2MRJ|rcsb pdb:2MRK|rcsb pdb:3H0F|rcsb pdb:3H0H|rcsb pdb:3H0I|rcsb pdb:3UA6|rcsb pdb:3UA7|rcsb pdb:4D8D|rcsb pdb:4EIK|rcsb pdb:4U17|rcsb pdb:4U1P|rcsb pdb:4ZNX|rcsb pdb:5ZAU|rcsb pdb:6EDF|rcsb pdb:6IPY|rcsb pdb:6IPZ|reactome:R-HSA-114604|reactome:R-HSA-1227986|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-399956|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-5621480|reactome:R-HSA-5621575|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-75892|reactome:R-HSA-8866376|reactome:R-HSA-9032500|reactome:R-HSA-9032759|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9706374|reactome:R-HSA-983695|reactome:R-HSA-9670439|uniprotkb:P06241(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GM5wIXENkJgPKwHN+UZBIqUfH6U9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:AA7DDE136A102110|rigid:WRjX9udTbWDIp8aaD9N1buWEJAs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75426 uniprotkb:B4DYC6 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-9357028 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482798|imex:IM-22301-1639 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1|uniprotkb:O75426(identity)|human orfeome collection:14332(identity)|entrezgene/locuslink:26261(identity)|ddbj/embl/genbank:BC067293 interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:9FEB924A0DB059A9|rigid:7qhxztS18Z1wYvXkqWs01QCengQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:O95199 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-742404|uniprotkb:B2RDW8|ensembl:ENSP00000345144 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:rcbt2_human(display_long)|uniprotkb:RCBTB2(gene name)|psi-mi:RCBTB2(display_short)|uniprotkb:CHC1L(gene name synonym)|uniprotkb:RLG(gene name synonym)|uniprotkb:Regulator of chromosome condensation and BTB domain-containing protein 2(gene name synonym)|uniprotkb:Chromosome condensation 1-like(gene name synonym)|uniprotkb:RCC1-like G exchanging factor(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482817|imex:IM-22301-1640 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_001259.1|refseq:NP_001273759.1|refseq:NP_001273760.1|refseq:NP_001273761.1|refseq:XP_005266299.1|refseq:XP_005266301.1|refseq:XP_006719822.1|ensembl:ENSG00000136161(gene)|ensembl:ENST00000344532(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011333(BTB/POZ fold)|uniprotkb:O95199(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:VJjauSy5q9k4V5QceqoSYZQ5ep49606 intact-crc:EE3BDDAF683FDBF0|rigid:FD5nPhZ1IdclLrZRK5hfliJFveU false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P21810 uniprotkb:Q8WVJ2 intact:EBI-762076|uniprotkb:P13247|uniprotkb:D3DWU3|ensembl:ENSP00000327336 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:pgs1_human(display_long)|uniprotkb:SLRR1A(gene name synonym)|uniprotkb:Bone/cartilage proteoglycan I(gene name synonym)|uniprotkb:PG-S1(gene name synonym)|uniprotkb:BGN(gene name)|psi-mi:BGN(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482880|imex:IM-22301-1644 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001702.1|refseq:XP_016885213.1|ensembl:ENSG00000182492(gene)|ensembl:ENST00000331595(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0019800"(peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030133"(transport vesicle)|go:"GO:0031012"(extracellular matrix)|go:"GO:0042383"(sarcolemma)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0060348"(bone development)|go:"GO:0061975"(articular cartilage development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR016352(Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan)|interpro:IPR028547|interpro:IPR032675|mint:P21810|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-4420332|uniprotkb:P21810(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:G7A6TRMpSIqTBpXtm67XG0GfM2w9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:D1C1DA38C5FF7EBC|rigid:ZT6d/QpeDgkAAvBoa8gZt0pJHUw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35590 uniprotkb:Q16543 intact:EBI-2256865|uniprotkb:B5A949|uniprotkb:B5A950|ensembl:ENSP00000361554 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:tie1_human(display_long)|uniprotkb:TIE1(gene name)|psi-mi:TIE1(display_short)|uniprotkb:TIE(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482911|imex:IM-22301-1646 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005415.1|ensembl:ENSG00000066056(gene)|ensembl:ENST00000372476(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P35590|rcsb pdb:5N06|uniprotkb:P35590(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:/tuK6SwU9CCcxFhdQo/rlvlPZRg9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:C241B3A49F6D36F3|rigid:P+nQT6J6ondLA7d5WDLY0cuB3LA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P42679 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-751664|uniprotkb:B3KNZ9|uniprotkb:Q9NST8|ensembl:ENSP00000308734 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:matk_human(display_long)|uniprotkb:Tyrosine-protein kinase CTK(gene name synonym)|uniprotkb:Protein kinase HYL(gene name synonym)|uniprotkb:Hematopoietic consensus tyrosine-lacking kinase(gene name synonym)|uniprotkb:MATK(gene name)|psi-mi:MATK(display_short)|uniprotkb:CTK(gene name synonym)|uniprotkb:HYL(gene name synonym)|uniprotkb:CSK homologous kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482934|imex:IM-22301-1647 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_002369.2|refseq:NP_647611.1|refseq:NP_647612.1|refseq:XP_011526320.1|ensembl:ENSG00000007264(gene)|ensembl:ENST00000310132(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JWO|rcsb pdb:1X6G|rcsb pdb:3US4|reactome:R-HSA-8863795|uniprotkb:P42679(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:zA5Bl6NIDDz31AJcm6u02v4bEe89606 intact-crc:9429849E14C99036|rigid:RmK+3Rl0cjovc300K6qjThQC2b4 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:P22607 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-348399|ensembl:ENSP00000414914|uniprotkb:Q14308|uniprotkb:Q16294|uniprotkb:Q16608|uniprotkb:D3DVP9|uniprotkb:D3DVQ0|uniprotkb:Q59FL9 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fgfr3_human(display_long)|uniprotkb:FGFR3(gene name)|psi-mi:FGFR3(display_short)|uniprotkb:JTK4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482895|imex:IM-22301-1645 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_000133.1|refseq:NP_001156685.1|refseq:NP_075254.1|ensembl:ENSG00000068078(gene)|ensembl:ENST00000440486(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001501"(skeletal system development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030133"(transport vesicle)|go:"GO:0030282"(bone mineralization)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048640"(negative regulation of developmental growth)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070977"(bone maturation)|go:"GO:1902178"(fibroblast growth factor receptor apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|rcsb pdb:1RY7|rcsb pdb:2LZL|rcsb pdb:4K33|rcsb pdb:6LVM|rcsb pdb:6PNX|rcsb pdb:7DHL|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839130|reactome:R-HSA-2033514|reactome:R-HSA-2033515|reactome:R-HSA-2219530|reactome:R-HSA-5654227|reactome:R-HSA-5654704|reactome:R-HSA-190371|reactome:R-HSA-190372|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654732|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853334|reactome:R-HSA-8853338|dip:DIP-4016N|uniprotkb:P22607(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:5yOR7/EmXO7Wff9yKMSdZuWjIKU9606 intact-crc:10D68BD6AB55DED4|rigid:WKCupec7Wc6tE033TV7v6GdaSKA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06828 uniprotkb:B4DYC6 intact:EBI-2833710|uniprotkb:Q8IV47|uniprotkb:Q15331|ensembl:ENSP00000347041 intact:EBI-9357028 psi-mi:fmod_human(display_long)|uniprotkb:FMOD(gene name)|psi-mi:FMOD(display_short)|uniprotkb:FM(gene name synonym)|uniprotkb:SLRR2E(gene name synonym)|uniprotkb:Collagen-binding 59 kDa protein(gene name synonym)|uniprotkb:Keratan sulfate proteoglycan fibromodulin(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482981|imex:IM-22301-1650 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007181"(transforming growth factor beta receptor complex assembly)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027215|interpro:IPR032675|rcsb pdb:5MX0|reactome:R-HSA-2022854|reactome:R-HSA-2022857|reactome:R-HSA-3000178|reactome:R-HSA-3656225|reactome:R-HSA-3656243|reactome:R-HSA-3656244|ensembl:ENSG00000122176(gene)|ensembl:ENST00000354955(transcript)|refseq:NP_002014.2|uniprotkb:Q06828(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:UeFgeq6sE7Q5zA0WmfhL+q3pgh49606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:7A835214B22ECDAF|rigid:3UcOHJo8WBKmUVX/pYdXlhsUm0U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q04725 uniprotkb:Q9Y266 intact:EBI-1176061|uniprotkb:Q8WVY0|uniprotkb:Q9Y6S0|ensembl:ENSP00000262953|uniprotkb:B4DE03|uniprotkb:E9PEV7|uniprotkb:F8WCH2 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:tle2_human(display_long)|uniprotkb:Enhancer of split groucho-like protein 2(gene name synonym)|uniprotkb:TLE2(gene name)|psi-mi:TLE2(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482966|imex:IM-22301-1649 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000065717(gene)|ensembl:ENST00000262953(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_001287775.1|refseq:NP_001138233.1|refseq:NP_001138234.1|refseq:NP_003251.2|interpro:IPR019775|interpro:IPR036322|mint:Q04725|reactome:R-HSA-201722|reactome:R-HSA-2122947|reactome:R-HSA-3769402|reactome:R-HSA-4641265|uniprotkb:Q04725(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:QlgGABrHV/Wi5v8Pb3SQAq+1gTU9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:21C87ED3BA0248D4|rigid:DFypLoS/pJ2g9/SpDcySrYHZHZM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P53671 uniprotkb:Q16543 intact:EBI-1384350|uniprotkb:Q7KZ80|uniprotkb:Q96E10|uniprotkb:Q99464|uniprotkb:A8K6H5|uniprotkb:Q9UFU0|uniprotkb:Q7L3H5|ensembl:ENSP00000332687 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:limk2_human(display_long)|uniprotkb:LIMK2(gene name)|psi-mi:LIMK2(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482950|imex:IM-22301-1648 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005560.1|refseq:NP_057952.1|refseq:NP_001026971.1|ensembl:ENSG00000182541(gene)|ensembl:ENST00000331728(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016310"(phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0060322"(head development)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|mint:P53671|rcsb pdb:1X6A|rcsb pdb:4TPT|rcsb pdb:5NXD|reactome:R-HSA-3928662|reactome:R-HSA-416572|reactome:R-HSA-5627117|uniprotkb:P53671(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:9Tt4TJshssdjMGb89YS+XrgJxDw9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:B6AFF7E9A114F7B1|rigid:Zt4PKQYVjlo7kZMlfIETG9JjC0k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q09019 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-724564|ensembl:ENSP00000270223 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9482997|imex:IM-22301-1651 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019|uniprotkb:Q09019(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 intact-crc:59C64D8F316B3063|rigid:Xjwgw5hBkdhbInJR/WAolQSI3aw false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q0VAA2 uniprotkb:B4DYC6 intact:EBI-8293626|uniprotkb:Q9Y627|intact:MINT-8407172|uniprotkb:Q6ZUG6|ensembl:ENSP00000377369 intact:EBI-9357028 psi-mi:lr74a_human(display_long)|uniprotkb:LRRC74A(gene name)|psi-mi:LRRC74A(display_short)|uniprotkb:C14orf166B(gene name synonym)|uniprotkb:LRRC74(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 74(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483012|imex:IM-22301-1652 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_919263.2|ensembl:ENSG00000100565(gene)|ensembl:ENST00000393774(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|uniprotkb:Q0VAA2(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) comment:mint|comment:homomint - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:LT5fE2WgyJnQyricXB/lkzahOf09606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:3A75417F738141E3|rigid:rGvkNn1HL6IykLTKBNp4NdrxeWk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12770 uniprotkb:Q9Y266 intact:EBI-6190187|ensembl:ENSP00000265565|ensembl:ENSP00000497087|uniprotkb:Q8N2E0|uniprotkb:Q8WUA1 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:scap_human(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)|uniprotkb:KIAA0199(gene name synonym)|uniprotkb:PSEC0227(orf name) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483028|imex:IM-22301-1653 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000114650(gene)|ensembl:ENST00000648151(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|ensembl:ENST00000265565(transcript)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|mint:Q12770|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|refseq:XP_011531803.1|refseq:NP_036367.2|refseq:XP_016861407.1|refseq:XP_016861410.1|uniprotkb:Q12770(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:bhavwLS6XzkZpAoBhCsII97JfpI9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:FC3DA468FFDC7AD2|rigid:5+7r34sjHt9k9MEZYM4QJLv2034 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q12788 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-715766|uniprotkb:Q59GD6|uniprotkb:Q8IVB7|intact:EBI-749106|uniprotkb:Q96A78|ensembl:ENSP00000454836 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:tbl3_human(display_long)|uniprotkb:WD repeat-containing protein SAZD(gene name synonym)|uniprotkb:TBL3(gene name)|psi-mi:TBL3(display_short)|uniprotkb:SAZD(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483043|imex:IM-22301-1654 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_006444.2|ensembl:ENSG00000183751(gene)|ensembl:ENST00000568546(transcript)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034511"(U3 snoRNA binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR013934(Small-subunit processome, Utp13)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q12788|reactome:R-HSA-6790901|reactome:R-HSA-6791226|uniprotkb:Q12788(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:XFWYZxef3kNBYeTaoSBWEXQoF/M9606 intact-crc:E12A9CFC1645ABFD|rigid:HixayJgEDv8fVjLYMy+xNtYJsps false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q13470 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1383444|uniprotkb:O95364|uniprotkb:Q8IYI4|ensembl:ENSP00000459799|ensembl:ENSP00000491136 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:tnk1_human(display_long)|uniprotkb:TNK1(gene name)|psi-mi:TNK1(display_short)|uniprotkb:CD38 negative kinase 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483090|imex:IM-22301-1657 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_003976.2|refseq:XP_011522347.1|refseq:NP_001238831.1|ensembl:ENSG00000174292(gene)|ensembl:ENSG00000283781(gene)|ensembl:ENST00000576812(transcript)|ensembl:ENST00000639430(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|mint:Q13470|uniprotkb:Q13470(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:PZ5qZxc2A2Ninx9igDperYpLUbc9606 intact-crc:652904506F22CAF5|rigid:EksLldM6wz2WZxqRQ1UvcRa0R0A false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q13470 intact:EBI-9357028 intact:EBI-1383444|uniprotkb:O95364|uniprotkb:Q8IYI4|ensembl:ENSP00000459799|ensembl:ENSP00000491136 psi-mi:b4dyc6_human(display_long) psi-mi:tnk1_human(display_long)|uniprotkb:TNK1(gene name)|psi-mi:TNK1(display_short)|uniprotkb:CD38 negative kinase 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483074|imex:IM-22301-1656 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_003976.2|refseq:XP_011522347.1|refseq:NP_001238831.1|ensembl:ENSG00000174292(gene)|ensembl:ENSG00000283781(gene)|ensembl:ENST00000576812(transcript)|ensembl:ENST00000639430(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|mint:Q13470|uniprotkb:Q13470(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:PZ5qZxc2A2Ninx9igDperYpLUbc9606 intact-crc:793787D6F44BDD5E|rigid:E0KcA6z6lZ8Zit4QvGrDVqp8FCs false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13164 uniprotkb:Q16543 intact:EBI-1213983|uniprotkb:Q16634|uniprotkb:Q59F50|uniprotkb:Q6QLU7|uniprotkb:Q7L4P4|uniprotkb:Q969G1|uniprotkb:Q96G51|intact:EBI-28979986|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:mk07_human(display_long)|uniprotkb:MAPK7(gene name)|psi-mi:MAPK7(display_short)|uniprotkb:BMK1(gene name synonym)|uniprotkb:ERK5(gene name synonym)|uniprotkb:PRKM7(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 5(gene name synonym)|uniprotkb:Big MAP kinase 1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483058|imex:IM-22301-1655 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002740.2|refseq:NP_620601.1|refseq:NP_620602.2|refseq:NP_620603.2|ensembl:ENST00000299612|ensembl:ENSP00000299612|ensembl:ENSP00000311005|ensembl:ENSP00000378966|ensembl:ENSP00000378968|refseq:XP_011522259.1|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13164|rcsb pdb:2Q8Y|rcsb pdb:4B99|rcsb pdb:4IC7|rcsb pdb:4IC8|rcsb pdb:4ZSG|rcsb pdb:4ZSJ|rcsb pdb:4ZSL|rcsb pdb:5BYY|rcsb pdb:5BYZ|rcsb pdb:5O7I|rcsb pdb:6HKM|rcsb pdb:6HKN|reactome:R-HSA-198753|reactome:R-HSA-198765|reactome:R-HSA-202670|reactome:R-HSA-2559582|reactome:R-HSA-881907|reactome:R-HSA-8853659|ensembl:ENSG00000166484(gene)|ensembl:ENST00000308406(transcript)|ensembl:ENST00000395602(transcript)|ensembl:ENST00000395604(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030154"(cell differentiation)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|uniprotkb:Q13164(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dUTMnlgdjEkFhq0i6RmvpX5U7BM9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:BE0058D994095783|rigid:6oL+jqCUOp1MzzbNfTFaMhO2pHg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14004 uniprotkb:Q16543 intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483122|imex:IM-22301-1659 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2|uniprotkb:Q14004(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:EB10AB27F04F648E|rigid:do19oAdVVB+56TMKeZKIQenqZ2c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14137 uniprotkb:B4DYC6 intact:EBI-1050828|uniprotkb:Q969Z6|uniprotkb:Q96IS8|uniprotkb:Q9BSA7|uniprotkb:Q9BVM0|ensembl:ENSP00000455106|ensembl:ENSP00000495401|uniprotkb:Q96Q25 intact:EBI-9357028 psi-mi:bop1_human(display_long)|uniprotkb:Block of proliferation 1 protein(gene name synonym)|uniprotkb:BOP1(gene name)|psi-mi:BOP1(display_short)|uniprotkb:KIAA0124(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483138|imex:IM-22301-1660 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056016.1|ensembl:ENSG00000261236(gene)|ensembl:ENSG00000285301(gene)|ensembl:ENST00000569669(transcript)|ensembl:ENST00000642409(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR012953(BOP1, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028598|interpro:IPR036322|mint:Q14137|reactome:R-HSA-6791226|uniprotkb:Q14137(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:g2CwsRotXBvjvr+rSZSA0mKrVCY9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:A6D6DBE2F31BD850|rigid:6dw6i74c4pC6pv/B5d4DXH14o1o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13546 uniprotkb:Q16543 intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483106|imex:IM-22301-1658 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)|uniprotkb:Q13546(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:97D56D53EC1F4E00|rigid:k+rAQuk2Fnj5HcGBNEf1t7cIKMA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16671 uniprotkb:Q16543 intact:EBI-6423788|ensembl:ENSP00000257863|uniprotkb:A0AVE1|uniprotkb:B9EGB7|uniprotkb:Q13762|uniprotkb:E9PGD2|uniprotkb:Q647K2|uniprotkb:F8W1D2 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:amhr2_human(display_long)|uniprotkb:AMHR2(gene name)|psi-mi:AMHR2(display_short)|uniprotkb:AMHR(gene name synonym)|uniprotkb:Anti-Muellerian hormone type II receptor(gene name synonym)|uniprotkb:MIS type II receptor(gene name synonym)|uniprotkb:MISR2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483200|imex:IM-22301-1664 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135409(gene)|ensembl:ENST00000257863(transcript)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007548"(sex differentiation)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0042562"(hormone binding)|go:"GO:0043235"(receptor complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1990262"(anti-Mullerian hormone signaling pathway)|go:"GO:1990272"(anti-Mullerian hormone receptor activity)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015771(Anti-muellerian hormone receptor, type II, C-terminal)|rcsb pdb:7L0J|reactome:R-HSA-201451|refseq:NP_001158163.1|refseq:NP_065434.1|refseq:NP_001158162.1|uniprotkb:Q16671(identity)|ddbj/embl/genbank:BC126316|human orfeome collection:54383(identity)|entrezgene/locuslink:269(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:NK97Ykth/EOUweZY2+dujr+Np8Q9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:C7A36DD1E7A0C12F|rigid:xKTWWgtd6MflTOm2h63hPJNWCww false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q149M9 uniprotkb:Q9Y266 intact:EBI-9477336|uniprotkb:Q68CT3|uniprotkb:C9J021|ensembl:ENSP00000447224 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:nwd1_human(display_long)|uniprotkb:NWD1(gene name)|psi-mi:NWD1(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483185|imex:IM-22301-1663 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277284.1|refseq:NP_001334923.1|refseq:XP_011526231.1|refseq:XP_011526232.1|refseq:XP_011526233.1|refseq:NP_001007526.3|ensembl:ENSG00000188039(gene)|ensembl:ENST00000552788(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027417|interpro:IPR043365|uniprotkb:Q149M9(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Bi9PAyjCPdeoLQWAeyXUlScGNm49606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:887A5CC98580BA72|rigid:FYh5EfuK+UVeRARbYXrPPffTZ2M false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q149M9 uniprotkb:B4DYC6 intact:EBI-9477336|uniprotkb:Q68CT3|uniprotkb:C9J021|ensembl:ENSP00000447224 intact:EBI-9357028 psi-mi:nwd1_human(display_long)|uniprotkb:NWD1(gene name)|psi-mi:NWD1(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483169|imex:IM-22301-1662 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277284.1|refseq:NP_001334923.1|refseq:XP_011526231.1|refseq:XP_011526232.1|refseq:XP_011526233.1|refseq:NP_001007526.3|ensembl:ENSG00000188039(gene)|ensembl:ENST00000552788(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027417|interpro:IPR043365|uniprotkb:Q149M9(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Bi9PAyjCPdeoLQWAeyXUlScGNm49606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:2E556ACA26C33968|rigid:lzoaX9zRQZvIH8AV4WFYp8zCp5s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q14137 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1050828|uniprotkb:Q969Z6|uniprotkb:Q96IS8|uniprotkb:Q9BSA7|uniprotkb:Q9BVM0|ensembl:ENSP00000455106|ensembl:ENSP00000495401|uniprotkb:Q96Q25 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:bop1_human(display_long)|uniprotkb:Block of proliferation 1 protein(gene name synonym)|uniprotkb:BOP1(gene name)|psi-mi:BOP1(display_short)|uniprotkb:KIAA0124(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483154|imex:IM-22301-1661 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_056016.1|ensembl:ENSG00000261236(gene)|ensembl:ENSG00000285301(gene)|ensembl:ENST00000569669(transcript)|ensembl:ENST00000642409(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR012953(BOP1, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028598|interpro:IPR036322|mint:Q14137|reactome:R-HSA-6791226|uniprotkb:Q14137(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:g2CwsRotXBvjvr+rSZSA0mKrVCY9606 intact-crc:8D9EF244FAD8BB9F|rigid:+JSino098hahYnOld4HXF8wjDpo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q16832 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1381484|uniprotkb:Q7Z730|ensembl:ENSP00000356898|ensembl:ENSP00000356899|ensembl:ENSP00000400309 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ddr2_human(display_long)|uniprotkb:Discoidin domain-containing receptor tyrosine kinase 2(gene name synonym)|uniprotkb:DDR2(gene name)|psi-mi:DDR2(display_short)|uniprotkb:NTRKR3(gene name synonym)|uniprotkb:TKT(gene name synonym)|uniprotkb:TYRO10(gene name synonym)|uniprotkb:Receptor protein-tyrosine kinase TKT(gene name synonym)|uniprotkb:Tyrosine-protein kinase TYRO10(gene name synonym)|uniprotkb:Neurotrophic tyrosine kinase, receptor-related 3(gene name synonym)|uniprotkb:CD167 antigen-like family member B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483219|imex:IM-22301-1665 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:XP_006711407.1|refseq:NP_001014796.1|refseq:NP_006173.2|refseq:XP_011507889.1|refseq:XP_011507888.1|dip:DIP-39699N|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020635|interpro:IPR034299|mint:Q16832|rcsb pdb:2WUH|rcsb pdb:2Z4F|rcsb pdb:6FER|rcsb pdb:7AZB|reactome:R-HSA-3000171|ensembl:ENSG00000162733(gene)|ensembl:ENST00000367921(transcript)|ensembl:ENST00000367922(transcript)|ensembl:ENST00000446985(transcript)|go:"GO:0001503"(ossification)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0035988"(chondrocyte proliferation)|go:"GO:0038062"(protein tyrosine kinase collagen receptor activity)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|uniprotkb:Q16832(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:aWup/fmqKPNU6Zg5aMeU8wKGUPU9606 intact-crc:F91C182BDEA28A9E|rigid:KM/1Bjp9g7e4mUbgyGH9m8MpP/c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2WGJ6 uniprotkb:Q9Y266 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483235|imex:IM-22301-1666 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1|uniprotkb:Q2WGJ6(identity)|ddbj/embl/genbank:BC127886|human orfeome collection:56933(identity)|entrezgene/locuslink:340359(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:81CBB91210DCA90B|rigid:+BCaiOAiMDxo7lMaBpviU9P/Avw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q53GT1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1996072|uniprotkb:D3DX30|uniprotkb:Q96B68|uniprotkb:Q96KC6|uniprotkb:A8MTV3|uniprotkb:A8K3Q4|ensembl:ENSP00000331682|uniprotkb:B7Z2G1 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh22_human(display_long)|uniprotkb:KLHL22(gene name)|psi-mi:KLHL22(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483253|imex:IM-22301-1667 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_116164.2|refseq:XP_016884510.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030575|mint:Q53GT1|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000099910(gene)|ensembl:ENST00000328879(transcript)|uniprotkb:Q53GT1(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:EC3vXSWYpde+ZCa6lm86DF+sfM89606 intact-crc:0E4E08AD83619350|rigid:c9JBSqBe6pa0EjM958culgowm6c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q53HC5 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-724915|uniprotkb:Q8TAP0|uniprotkb:Q9NUX3|ensembl:ENSP00000300976 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh26_human(display_long)|uniprotkb:KLHL26(gene name)|psi-mi:KLHL26(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483268|imex:IM-22301-1668 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_060786.1|ensembl:ENSG00000167487(gene)|ensembl:ENST00000300976(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030588|mint:Q53HC5|uniprotkb:Q53HC5(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:ttSomgoE7proVj7jmp9Umc/IbXk9606 intact-crc:F335BFB3827E2946|rigid:1fuw4jFM+AsHljrvvqSEQ5CWS6E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q53HC5 uniprotkb:Q8WVJ2 intact:EBI-724915|uniprotkb:Q8TAP0|uniprotkb:Q9NUX3|ensembl:ENSP00000300976 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:klh26_human(display_long)|uniprotkb:KLHL26(gene name)|psi-mi:KLHL26(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483283|imex:IM-22301-1669 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060786.1|ensembl:ENSG00000167487(gene)|ensembl:ENST00000300976(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030588|mint:Q53HC5|uniprotkb:Q53HC5(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ttSomgoE7proVj7jmp9Umc/IbXk9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:DEF286E8E3B4AB7D|rigid:xd6FV+41J2YO/GkZ6Y/HtFkmPFE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q53HC5 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-724915|uniprotkb:Q8TAP0|uniprotkb:Q9NUX3|ensembl:ENSP00000300976 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:klh26_human(display_long)|uniprotkb:KLHL26(gene name)|psi-mi:KLHL26(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483298|imex:IM-22301-1670 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_060786.1|ensembl:ENSG00000167487(gene)|ensembl:ENST00000300976(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030588|mint:Q53HC5|uniprotkb:Q53HC5(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:ttSomgoE7proVj7jmp9Umc/IbXk9606 intact-crc:345F092078EF8D23|rigid:bklArl3TOfIvV6HWc0LCr5uTZgg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q562E7 uniprotkb:Q9Y266 intact:EBI-5235360|uniprotkb:Q24JP6|uniprotkb:Q8N277|uniprotkb:Q8N3F3|uniprotkb:B3KW16|uniprotkb:B3KXU1|uniprotkb:B7Z579|uniprotkb:E9PHG7|uniprotkb:Q8TEL1|ensembl:ENSP00000386609 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:wdr81_human(display_long)|uniprotkb:WDR81(gene name)|psi-mi:WDR81(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483313|imex:IM-22301-1671 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011521953.1|refseq:NP_001157145.1|refseq:NP_001157281.1|refseq:NP_001157283.1|refseq:NP_689561.2|ensembl:ENSG00000167716(gene)|ensembl:ENST00000409644(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0035973"(aggrephagy)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR036372|reactome:R-HSA-9013148|go:"GO:0045022"(early endosome to late endosome transport)|uniprotkb:Q562E7(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WZMmbrspcu0HwOC1iuqrGa4NA2s9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:CC2CB4E22174799F|rigid:noJAKvTfxOQNhnUBvw6ZN7+aLHk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6JEL2 uniprotkb:B4DYC6 intact:EBI-6426253|ensembl:ENSP00000293303|uniprotkb:Q96MC0|uniprotkb:Q6NW28 intact:EBI-9357028 psi-mi:klh10_human(display_long)|uniprotkb:KLHL10(gene name)|psi-mi:KLHL10(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483362|imex:IM-22301-1674 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000161594(gene)|ensembl:ENST00000293303(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008584"(male gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030608|refseq:NP_689680.2|refseq:NP_001316524.1|refseq:NP_001316525.1|uniprotkb:Q6JEL2(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:noshmISifSfSBK9vrzh7dYqJ+bA9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:7E37BD84CDE632AA|rigid:we19ArOFHxqAbBIlvVAeU3mTcwc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q5BKY1 intact:EBI-9357028 intact:EBI-9477503|uniprotkb:Q6ZVY4|ensembl:ENSP00000355166 psi-mi:b4dyc6_human(display_long) psi-mi:lrc10_human(display_long)|uniprotkb:LRRC10(gene name)|psi-mi:LRRC10(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483328|imex:IM-22301-1672 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_963844.2|ensembl:ENSG00000198812(gene)|ensembl:ENST00000361484(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0055013"(cardiac muscle cell development)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|uniprotkb:Q5BKY1(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:f77OVT34OWBmguFweuxXAdf/T/g9606 intact-crc:0DA7ECF2BF070B96|rigid:uDyCI+NjDSS/UCdL52NuJGg8vog false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q6FHF7 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9376480 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:q6fhf7_human(display_long)|uniprotkb:RABGGTA(gene name)|psi-mi:RABGGTA(display_short)|uniprotkb:Geranylgeranyl transferase type II subunit alpha(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483344|imex:IM-22301-1673 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) interpro:IPR032955|interpro:IPR032675|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002088(Protein prenyltransferase, alpha subunit)|interpro:IPR009087(Rab geranylgeranyltransferase, alpha subunit, insert)|interpro:IPR036254|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018344"(protein geranylgeranylation)|uniprotkb:Q6FHF7(identity)|entrezgene/locuslink:5875(identity)|ddbj/embl/genbank:BC003093|human orfeome collection:3713(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:bmH4iYPmL+zH7uQlnoUtOnAlc5w9606 intact-crc:7844CA958F4B1E77|rigid:MYiOgmrQ3ghaQ52D60pu0VWVq7k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6NSJ5 uniprotkb:B4DYC6 intact:EBI-8647013|ensembl:ENSP00000306524|ensembl:ENSP00000479953|uniprotkb:Q7L236|uniprotkb:Q8N3B0|uniprotkb:Q2YDY3|uniprotkb:Q9H5H8|uniprotkb:B3KR78|intact:MINT-8163602 intact:EBI-9357028 psi-mi:lrc8e_human(display_long)|uniprotkb:LRRC8E(gene name)|psi-mi:LRRC8E(display_short)|uniprotkb:Leucine-rich repeat-containing protein 8E(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483393|imex:IM-22301-1676 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000171017(gene)|ensembl:ENST00000306708(transcript)|ensembl:ENST00000618098(transcript)|go:"GO:0005225"(volume-sensitive anion channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034702"(ion channel complex)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0098656"(anion transmembrane transport)|go:"GO:0140361"(cyclic-GMP-AMP transmembrane import across plasma membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|reactome:R-HSA-5223345|interpro:IPR032675|refseq:XP_011526621.1|refseq:NP_001255213.1|refseq:NP_079337.2|refseq:NP_001255214.1|dip:DIP-61363N|uniprotkb:Q6NSJ5(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) comment:mint - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:pQHkswfwifVqchBKu1+iMkt+0qo9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:D1D6B9DFEBFF96E3|rigid:DQivXrCzKsSvbnX3hlT+JGtmrf8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6JEL2 uniprotkb:Q8IVD9 intact:EBI-6426253|ensembl:ENSP00000293303|uniprotkb:Q96MC0|uniprotkb:Q6NW28 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh10_human(display_long)|uniprotkb:KLHL10(gene name)|psi-mi:KLHL10(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483378|imex:IM-22301-1675 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000161594(gene)|ensembl:ENST00000293303(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008584"(male gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030608|refseq:NP_689680.2|refseq:NP_001316524.1|refseq:NP_001316525.1|uniprotkb:Q6JEL2(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:noshmISifSfSBK9vrzh7dYqJ+bA9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:5F5249BA75E222B7|rigid:DJdAkXK6qMW1mjWu5Y0uZAYMkB4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P2D8 uniprotkb:B4DYC6 intact:EBI-9477592|uniprotkb:J3KNJ1|uniprotkb:Q7RTT7|uniprotkb:Q7Z463|uniprotkb:B5MD90|uniprotkb:Q7Z4U0|ensembl:ENSP00000339918 intact:EBI-9357028 psi-mi:xrra1_human(display_long)|uniprotkb:XRRA1(gene name)|psi-mi:XRRA1(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483409|imex:IM-22301-1677 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001257309.1|refseq:NP_001257310.1|refseq:NP_892014.1|refseq:XP_016872722.1|refseq:XP_016872723.1|ensembl:ENSG00000166435(gene)|ensembl:ENST00000340360(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0010165"(response to X-ray)|go:"GO:0016604"(nuclear body)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR038894|uniprotkb:Q6P2D8(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:sNAHqFX4myyh5qi8LUoMFfXFU589606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:C4239BEE0DEFD028|rigid:uAJZRJA3iy03xoZkWOEWVEaF9tA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6P9F7 uniprotkb:B4DYC6 intact:EBI-9477617|uniprotkb:Q92627|uniprotkb:Q8N106|uniprotkb:D3DT28|uniprotkb:Q6UY21|ensembl:ENSP00000332674|ensembl:ENSP00000491377|ensembl:ENSP00000492151 intact:EBI-9357028 psi-mi:lrc8b_human(display_long)|uniprotkb:LRRC8B(gene name)|psi-mi:LRRC8B(display_short)|uniprotkb:Leucine-rich repeat-containing protein 8B(gene name synonym)|uniprotkb:KIAA0231(gene name synonym)|uniprotkb:T-cell activation leucine repeat-rich protein(gene name synonym)|uniprotkb:UNQ6413/PRO21207(orf name) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483425|imex:IM-22301-1678 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011539445.1|refseq:XP_011539446.1|refseq:XP_011539447.1|refseq:XP_011539448.1|refseq:XP_016856372.1|refseq:XP_016856373.1|refseq:XP_016856374.1|refseq:NP_001127948.1|refseq:NP_056165.1|refseq:XP_005270758.1|refseq:XP_005270759.1|refseq:XP_005270760.1|dip:DIP-61361N|ensembl:ENSG00000197147(gene)|ensembl:ENST00000330947(transcript)|ensembl:ENST00000639264(transcript)|ensembl:ENST00000640258(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015698"(inorganic anion transport)|go:"GO:0034702"(ion channel complex)|go:"GO:0098656"(anion transmembrane transport)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR021040|interpro:IPR026906|interpro:IPR032675|reactome:R-HSA-5223345|uniprotkb:Q6P9F7(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:QlA1G8RWBlSD2IaaRuCuUA1VQvg9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:E3CE7FF76A98C0E3|rigid:dMX9xwHc344sIzZPCYpIaa/KSvg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PCT2 uniprotkb:B4DYC6 intact:EBI-6664563|ensembl:ENSP00000455529|uniprotkb:A8MT10|uniprotkb:Q8N789|uniprotkb:Q9NT14 intact:EBI-9357028 psi-mi:fxl19_human(display_long)|uniprotkb:FBXL19(gene name)|psi-mi:FBXL19(display_short)|uniprotkb:FBL19(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 19(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483441|imex:IM-22301-1679 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000099364(gene)|ensembl:ENST00000562319(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006482"(protein demethylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045322"(unmethylated CpG binding)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019787|interpro:IPR032675|mint:Q6PCT2|rcsb pdb:6ASB|reactome:R-HSA-8951664|reactome:R-HSA-983168|interpro:IPR019786|refseq:NP_001269280.1|refseq:NP_001093254.2|uniprotkb:Q6PCT2(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:wtar4oBKcxTqx7B6RWX9BQgriVY9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:E1C200E6CF73CCE3|rigid:7+9MkSJZOmp3ZdmX9d09xO999rk false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PHR2 uniprotkb:Q16543 intact:EBI-1383475|uniprotkb:B2RXK3|uniprotkb:Q9NPN5|uniprotkb:Q9UFS4|uniprotkb:B4DRQ7|uniprotkb:D3DW68|uniprotkb:B4DFT0|ensembl:ENSP00000400312 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ulk3_human(display_long)|uniprotkb:ULK3(gene name)|psi-mi:ULK3(display_short)|uniprotkb:Unc-51-like kinase 3(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483472|imex:IM-22301-1681 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005254346.1|refseq:NP_001271293.2|refseq:NP_001092906.3|refseq:NP_001271294.1|ensembl:ENSG00000140474(gene)|ensembl:ENST00000440863(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0006914"(autophagy)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0072537"(fibroblast activation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097542"(ciliary tip)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905037"(autophagosome organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR007330(MIT)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036181|rcsb pdb:4WZX|rcsb pdb:6FDY|rcsb pdb:6FDZ|reactome:R-HSA-5632684|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|uniprotkb:Q6PHR2(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:B/PdKBoRF2UdrRIBktKbIrjFghE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:DF8469808F295CC8|rigid:tWf5cnodW+/OEuX3z5VuixBZ6yU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PF15 uniprotkb:Q8IVD9 intact:EBI-9477654|uniprotkb:A2RU06|uniprotkb:Q86XM7|uniprotkb:Q8NBB1|uniprotkb:F5H412|ensembl:ENSP00000438526 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh35_human(display_long)|uniprotkb:KLHL35(gene name)|psi-mi:KLHL35(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483457|imex:IM-22301-1680 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034637.2|ensembl:ENSG00000149243(gene)|ensembl:ENST00000539798(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030601|interpro:IPR006652(Kelch repeat type 1)|uniprotkb:Q6PF15(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VBNYciXfqfZSiZ1OW4aQ5P9/8Qw9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:29B660015EA066C8|rigid:5Uo8uPfTWHphDTuT/19QlStmwv0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6PID8 uniprotkb:Q8IVD9 intact:EBI-3201175|uniprotkb:Q86Y99|uniprotkb:Q92554|ensembl:ENSP00000334140 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:kld10_human(display_long)|uniprotkb:KLHDC10(gene name)|psi-mi:KLHDC10(display_short)|uniprotkb:KIAA0265(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483504|imex:IM-22301-1683 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055812.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|mint:Q6PID8|ensembl:ENSG00000128607(gene)|ensembl:ENST00000335420(transcript)|uniprotkb:Q6PID8(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3uIxELU4dOhu3brVaF2yvzyy+hI9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:7C8ADF0950E945DB|rigid:xzItR4/lpEJBBO63C+tbONW+zAM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q6PID8 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-3201175|uniprotkb:Q86Y99|uniprotkb:Q92554|ensembl:ENSP00000334140 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:kld10_human(display_long)|uniprotkb:KLHDC10(gene name)|psi-mi:KLHDC10(display_short)|uniprotkb:KIAA0265(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483488|imex:IM-22301-1682 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_055812.1|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|mint:Q6PID8|ensembl:ENSG00000128607(gene)|ensembl:ENST00000335420(transcript)|uniprotkb:Q6PID8(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:3uIxELU4dOhu3brVaF2yvzyy+hI9606 intact-crc:1A7A844AF1C89D6E|rigid:NKuU5EKL0/yz8u17Jduy6G5wN2E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q6UY01 intact:EBI-9357028 intact:EBI-9477727|uniprotkb:Q9H5N5|uniprotkb:B7ZL44|uniprotkb:Q17RA3|uniprotkb:Q8N848|uniprotkb:E5RJA9|uniprotkb:V9HW14|ensembl:ENSP00000325978 psi-mi:b4dyc6_human(display_long) psi-mi:lrc31_human(display_long)|uniprotkb:LRRC31(gene name)|psi-mi:LRRC31(display_short)|uniprotkb:UNQ9367/PRO34156(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483519|imex:IM-22301-1684 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:XP_011511462.1|refseq:NP_001264056.1|refseq:NP_001264057.1|refseq:NP_079003.2|ensembl:ENSG00000114248(gene)|ensembl:ENST00000316428(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|interpro:IPR042419|uniprotkb:Q6UY01(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:mkY299CUdJrZElu8oAkBpSNpqQE9606 intact-crc:F7DCAEDD6B2004AF|rigid:pIv9Kk+97wTctpbfMZGgyZZIU8s false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZMY6 uniprotkb:Q9Y266 intact:EBI-2799773|uniprotkb:Q8NEF8|ensembl:ENSP00000348129 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:wdr88_human(display_long)|uniprotkb:PQWD(gene name synonym)|uniprotkb:PQQ repeat and WD repeat-containing protein(gene name synonym)|uniprotkb:WDR88(gene name)|psi-mi:WDR88(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483535|imex:IM-22301-1685 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_775750.3|ensembl:ENSG00000166359(gene)|ensembl:ENST00000355868(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR002372(Pyrrolo-quinoline quinone)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR019775|interpro:IPR020472|uniprotkb:Q6ZMY6(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:2wNa6tEuHWCmJUafHOpgDT4kp789606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:53BC139475447CA0|rigid:TqA96i0cwYl5gVqHxzv4jOFTUqo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6ZN16 uniprotkb:Q16543 intact:EBI-2865050|uniprotkb:Q6ZMV3|uniprotkb:A2AI50|uniprotkb:Q5JPR4|uniprotkb:A6NJ61|uniprotkb:A2AI49|ensembl:ENSP00000345629 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:m3k15_human(display_long)|uniprotkb:MAP3K15(gene name)|psi-mi:MAP3K15(display_short)|uniprotkb:ASK3(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 15(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483550|imex:IM-22301-1686 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011543813.1|refseq:NP_001001671.3|ensembl:ENSG00000180815(gene)|ensembl:ENST00000338883(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|rcsb pdb:6V0M|uniprotkb:Q6ZN16(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8s8R8yiu4OKPfxnuLAeH48wi25c9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:4E8E5F233C07D7BA|rigid:SjpQcn/RyMEE10Fp/VofCMSc/eI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z5L7 uniprotkb:B4DYC6 intact:EBI-9477785|uniprotkb:Q6UXL8|uniprotkb:B4E373|uniprotkb:Q6PIR3|uniprotkb:Q5VVZ2|uniprotkb:Q8N641|uniprotkb:B4DKN5|uniprotkb:Q5VVZ3|ensembl:ENSP00000308315 intact:EBI-9357028 psi-mi:podn_human(display_long)|uniprotkb:PODN(gene name)|psi-mi:PODN(display_short)|uniprotkb:SLRR5A(gene name synonym)|uniprotkb:UNQ293/PRO332(orf name) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483566|imex:IM-22301-1687 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000174348(gene)|ensembl:ENST00000312553(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR026906|interpro:IPR032675|refseq:NP_001186009.1|refseq:NP_001186010.1|refseq:NP_714914.2|refseq:XP_005270514.1|uniprotkb:Q7Z5L7(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:uBshQmlSfHwxjM9J5vllMb03KlI9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:7A29C234E9A153BB|rigid:qfrG7YSoFx09skp/hqJb00X+RoI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q86SG6 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-1752987|uniprotkb:A6NIC5|uniprotkb:Q14CL7|uniprotkb:Q2M1S6|uniprotkb:Q8NDH1|ensembl:ENSP00000268766 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:nek8_human(display_long)|uniprotkb:NEK8(gene name)|psi-mi:NEK8(display_short)|uniprotkb:JCK(gene name synonym)|uniprotkb:NEK12A(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 8(gene name synonym)|uniprotkb:Nima-related protein kinase 12a(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483582|imex:IM-22301-1688 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_835464.1|ensembl:ENSG00000160602(gene)|ensembl:ENST00000268766(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0097543"(ciliary inversin compartment)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044120|uniprotkb:Q86SG6(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:oQZn3YdYQI5TLOQzhFQxE3+cEGw9606 intact-crc:76B863AC74E5DAF3|rigid:EFXemru1Nhzi5H8sZE22TGKUPfA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q86UN3 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-2556551|uniprotkb:Q6X813|uniprotkb:Q17RL9|ensembl:ENSP00000335397|uniprotkb:Q0GGW3 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:r4rl2_human(display_long)|uniprotkb:NGRH1(gene name synonym)|uniprotkb:NGRL3(gene name synonym)|uniprotkb:Nogo-66 receptor homolog 1(gene name synonym)|uniprotkb:Nogo-66 receptor-related protein 2(gene name synonym)|uniprotkb:Nogo receptor-like 3(gene name synonym)|uniprotkb:RTN4RL2(gene name)|psi-mi:RTN4RL2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483597|imex:IM-22301-1689 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_848665.1|ensembl:ENSG00000186907(gene)|ensembl:ENST00000335099(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031103"(axon regeneration)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0045121"(membrane raft)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-163125|uniprotkb:Q86UN3(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:DRxsag7lb+kfAX784SyOGrhTYQQ9606 intact-crc:77A8536E7D1EB620|rigid:GGfjdYK6ac5r7lWPSP1HGUYgc1w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86YV6 uniprotkb:Q16543 intact:EBI-6424604|ensembl:ENSP00000274643|uniprotkb:A2RUC0|uniprotkb:Q5TAW2 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:mylk4_human(display_long)|uniprotkb:MYLK4(gene name)|psi-mi:MYLK4(display_short)|uniprotkb:SGK085(gene name synonym)|uniprotkb:Sugen kinase 85(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483627|imex:IM-22301-1691 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001334801.1|ensembl:ENSG00000145949(gene)|ensembl:ENST00000274643(transcript)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2X4F|refseq:NP_001012418.2|refseq:XP_005249136.1|refseq:XP_016866308.1|uniprotkb:Q86YV6(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HgJeFkJ8bBvh+Nq9EO7dWCGbunI9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:70D8985A7715F388|rigid:0G32MiZVOIcg1Is21qk0Cae5kvo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q86W42 uniprotkb:Q9Y266 intact:EBI-2880668|ensembl:ENSP00000326531|uniprotkb:Q8NBR1|uniprotkb:B2RA85|uniprotkb:Q9BTV9 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:thoc6_human(display_long)|uniprotkb:THOC6(gene name)|psi-mi:THOC6(display_short)|uniprotkb:WDR58(gene name synonym)|uniprotkb:Functional spliceosome-associated protein 35(gene name synonym)|uniprotkb:WD repeat-containing protein 58(gene name synonym)|uniprotkb:PSEC0006(orf name) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483612|imex:IM-22301-1690 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000131652(gene)|ensembl:ENST00000326266(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0000347"(THO complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR042626|mint:Q86W42|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_001135822.1|refseq:NP_077315.2|refseq:NP_001334632.1|refseq:NP_001334633.1|uniprotkb:Q86W42(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mmpU10uiZc1+MK8ntLeD+GCVIOM9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:5A0DBF15908290C0|rigid:ZRHna4TRW+bN0Vw1Pdo6Kh3dY6w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IWZ6 uniprotkb:Q9Y266 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483659|imex:IM-22301-1693 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome)|uniprotkb:Q8IWZ6(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:65DABB76C7FE592D|rigid:vhxj+Bd6y8k9J5mhCehXgWYXqQ0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IUZ0 uniprotkb:B4DYC6 intact:EBI-9477875|uniprotkb:B7Z366|uniprotkb:G5E9T5|uniprotkb:Q9NXM6|uniprotkb:H0YLN4|uniprotkb:B3KVX1|uniprotkb:F5H1J4|ensembl:ENSP00000260382 intact:EBI-9357028 psi-mi:lrc49_human(display_long)|uniprotkb:LRRC49(gene name)|psi-mi:LRRC49(display_short)|uniprotkb:Tubulin polyglutamylase complex subunit 4(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483643|imex:IM-22301-1692 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520017.1|refseq:XP_016877847.1|refseq:NP_001271286.1|refseq:NP_001185946.1|refseq:NP_001185947.1|refseq:NP_060161.2|go:"GO:0005874"(microtubule)|go:"GO:0036158"(outer dynein arm assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q8IUZ0|reactome:R-HSA-8955332|ensembl:ENSG00000137821(gene)|ensembl:ENST00000260382(transcript)|go:"GO:0005737"(cytoplasm)|uniprotkb:Q8IUZ0(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:6e+i7lca3hMpmbOQuv8GkDVEfoM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:FDD07778EC0B1484|rigid:+UTp/da44iSjgqfhzmZC1tco0Kc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IYD2 uniprotkb:Q8IVD9 intact:EBI-9477915|uniprotkb:Q9NVG5|uniprotkb:B3KU70|ensembl:ENSP00000356123|ensembl:ENSP00000356124|ensembl:ENSP00000442229 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:kld8a_human(display_long)|uniprotkb:KLHDC8A(gene name)|psi-mi:KLHDC8A(display_short)|uniprotkb:Substitute for delta-EGFR expression 1(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483674|imex:IM-22301-1694 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001258792.1|refseq:NP_001258793.1|refseq:NP_001258794.1|refseq:NP_060673.1|ensembl:ENSG00000162873(gene)|ensembl:ENST00000367155(transcript)|ensembl:ENST00000367156(transcript)|ensembl:ENST00000539253(transcript)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q8IYD2(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jiiy1xwzPll5c7LRZtAuhlRHQdg9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:17F83A8A300CF5D9|rigid:Nt+SbHGBnz1f7NaCU4jJ/TxnTLg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IYD2 uniprotkb:Q9Y266 intact:EBI-9477915|uniprotkb:Q9NVG5|uniprotkb:B3KU70|ensembl:ENSP00000356123|ensembl:ENSP00000356124|ensembl:ENSP00000442229 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:kld8a_human(display_long)|uniprotkb:KLHDC8A(gene name)|psi-mi:KLHDC8A(display_short)|uniprotkb:Substitute for delta-EGFR expression 1(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483689|imex:IM-22301-1695 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001258792.1|refseq:NP_001258793.1|refseq:NP_001258794.1|refseq:NP_060673.1|ensembl:ENSG00000162873(gene)|ensembl:ENST00000367155(transcript)|ensembl:ENST00000367156(transcript)|ensembl:ENST00000539253(transcript)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q8IYD2(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jiiy1xwzPll5c7LRZtAuhlRHQdg9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:2DEC332356F99E13|rigid:aRO+KJ570e/eXzwI8/m1suNWqDY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1V2 uniprotkb:Q8IVD9 intact:EBI-9477948|uniprotkb:B2RDU7|uniprotkb:Q8TC73|uniprotkb:Q8TCI3|uniprotkb:Q5DX23|ensembl:ENSP00000339449 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:cfa52_human(display_long)|uniprotkb:CFAP52(gene name)|psi-mi:CFAP52(display_short)|uniprotkb:WD repeat-containing protein 16(gene name synonym)|uniprotkb:WD40-repeat protein up-regulated in HCC(gene name synonym)|uniprotkb:WDR16(gene name synonym)|uniprotkb:WDRPUH(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483704|imex:IM-22301-1696 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074025.1|refseq:NP_659491.4|ensembl:ENSG00000166596(gene)|ensembl:ENST00000352665(transcript)|go:"GO:0005930"(axoneme)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0060271"(cilium assembly)|go:"GO:0061966"(establishment of left/right asymmetry)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR033015|interpro:IPR036322|uniprotkb:Q8N1V2(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+2LL5BH1Np4TMtwDF7V+vF7bijg9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:08161D62AF1464DD|rigid:TAkoR+gTgsE40gN1SuipedZ9SZo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8N1V2 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9477948|uniprotkb:B2RDU7|uniprotkb:Q8TC73|uniprotkb:Q8TCI3|uniprotkb:Q5DX23|ensembl:ENSP00000339449 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:cfa52_human(display_long)|uniprotkb:CFAP52(gene name)|psi-mi:CFAP52(display_short)|uniprotkb:WD repeat-containing protein 16(gene name synonym)|uniprotkb:WD40-repeat protein up-regulated in HCC(gene name synonym)|uniprotkb:WDR16(gene name synonym)|uniprotkb:WDRPUH(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483735|imex:IM-22301-1698 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_001074025.1|refseq:NP_659491.4|ensembl:ENSG00000166596(gene)|ensembl:ENST00000352665(transcript)|go:"GO:0005930"(axoneme)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0060271"(cilium assembly)|go:"GO:0061966"(establishment of left/right asymmetry)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR033015|interpro:IPR036322|uniprotkb:Q8N1V2(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:+2LL5BH1Np4TMtwDF7V+vF7bijg9606 intact-crc:B9D3ED8A22565001|rigid:2mLtCB8RiAHrWPuhQ7V+1nKDZPA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q8N1V2 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-9477948|uniprotkb:B2RDU7|uniprotkb:Q8TC73|uniprotkb:Q8TCI3|uniprotkb:Q5DX23|ensembl:ENSP00000339449 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:cfa52_human(display_long)|uniprotkb:CFAP52(gene name)|psi-mi:CFAP52(display_short)|uniprotkb:WD repeat-containing protein 16(gene name synonym)|uniprotkb:WD40-repeat protein up-regulated in HCC(gene name synonym)|uniprotkb:WDR16(gene name synonym)|uniprotkb:WDRPUH(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483719|imex:IM-22301-1697 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_001074025.1|refseq:NP_659491.4|ensembl:ENSG00000166596(gene)|ensembl:ENST00000352665(transcript)|go:"GO:0005930"(axoneme)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0060271"(cilium assembly)|go:"GO:0061966"(establishment of left/right asymmetry)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR033015|interpro:IPR036322|uniprotkb:Q8N1V2(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:+2LL5BH1Np4TMtwDF7V+vF7bijg9606 intact-crc:97E4D250F4BBAF3E|rigid:USY7PCYPYfK+PbI3xI7mWJGfAlA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N239 uniprotkb:Q8IVD9 intact:EBI-6426410|ensembl:ENSP00000368813 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh34_human(display_long)|uniprotkb:KLHL34(gene name)|psi-mi:KLHL34(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483750|imex:IM-22301-1699 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185915(gene)|ensembl:ENST00000379499(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_695002.1|uniprotkb:Q8N239(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:R5DX0fP25R6hzFSF6mf7G91zi1g9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:15931017AE28168D|rigid:I96Iv/P6LIgF3ztI61ABSNDheeY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N239 uniprotkb:Q9Y266 intact:EBI-6426410|ensembl:ENSP00000368813 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:klh34_human(display_long)|uniprotkb:KLHL34(gene name)|psi-mi:KLHL34(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483766|imex:IM-22301-1700 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185915(gene)|ensembl:ENST00000379499(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_695002.1|uniprotkb:Q8N239(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:R5DX0fP25R6hzFSF6mf7G91zi1g9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:6FFCB1F5337F379A|rigid:Y6K/Y3gmexAMuKGMpkwxV02oryw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N456 uniprotkb:B4DYC6 intact:EBI-751373|uniprotkb:Q6UY02|ensembl:ENSP00000363275 intact:EBI-9357028 psi-mi:lrc18_human(display_long)|uniprotkb:LRRC18(gene name)|psi-mi:LRRC18(display_short)|uniprotkb:UNQ9338/PRO34010(orf name) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483781|imex:IM-22301-1701 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001006940.3|refseq:XP_011538124.1|refseq:XP_011538125.1|refseq:XP_011538128.1|refseq:XP_011538130.1|refseq:XP_011538131.1|refseq:XP_006717930.1|refseq:XP_016871765.1|refseq:XP_016871766.1|ensembl:ENSG00000165383(gene)|ensembl:ENST00000374160(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|uniprotkb:Q8N456(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:gKc5evWyzPYpUr8KIzDu4I9Oy4A9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:981CB04D7A701842|rigid:QPkm3U7nkfOdejZO2A9BsWULfXI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N4N3 uniprotkb:Q8IVD9 intact:EBI-6426427|ensembl:ENSP00000456743|uniprotkb:Q9H9U6|uniprotkb:Q8N5G6 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh36_human(display_long)|uniprotkb:KLHL36(gene name)|psi-mi:KLHL36(display_short)|uniprotkb:C16orf44(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483797|imex:IM-22301-1702 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016879163.1|refseq:XP_016879164.1|ensembl:ENSG00000135686(gene)|ensembl:ENST00000564996(transcript)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030585|go:"GO:0016567"(protein ubiquitination)|refseq:NP_001290380.1|refseq:NP_079007.2|refseq:XP_005256206.1|uniprotkb:Q8N4N3(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gm90Z8DLfx8ZkzB6zrJMLqLWt389606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:A26D8054842EC815|rigid:znTbWlp7IUwV5Llt9GLYzs87T+w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N5D0 uniprotkb:Q9Y266 intact:EBI-311222|uniprotkb:Q9NV87|uniprotkb:Q9UPW4|intact:EBI-2559106|uniprotkb:Q5SSC5|uniprotkb:D3DPL5|ensembl:ENSP00000317971 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:wdtc1_human(display_long)|uniprotkb:WDTC1(gene name)|psi-mi:WDTC1(display_short)|uniprotkb:KIAA1037(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483812|imex:IM-22301-1703 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055838.2|ensembl:ENSG00000142784(gene)|ensembl:ENST00000319394(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0055082"(cellular chemical homeostasis)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019734|interpro:IPR036322|rcsb pdb:3I7N|reactome:R-HSA-8951664|refseq:XP_011539359.1|refseq:NP_001263181.1|dip:DIP-31627N|uniprotkb:Q8N5D0(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:jAsFFwoAfRkN+OVv32DRidscyi09606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:C3E48785730195A4|rigid:WCIeyst23qCt25To89jtUHn+1NU false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q8N7A1 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9478080|uniprotkb:B3KXD9|uniprotkb:Q8WYI1|ensembl:ENSP00000352282 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:kldc1_human(display_long)|uniprotkb:KLHDC1(gene name)|psi-mi:KLHDC1(display_short)|uniprotkb:MSTP025(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483827|imex:IM-22301-1704 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_751943.1|ensembl:ENSG00000197776(gene)|ensembl:ENST00000359332(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q8N7A1(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:J4WCrNJCBtEGJ3t2QmgZ8SUlldU9606 intact-crc:3E56014D591C9042|rigid:3pxuRLxppBt4a/b24R+g36/7IfA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8NA23 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9478116|uniprotkb:Q96EG8|uniprotkb:Q5W0T9|ensembl:ENSP00000363308 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:wdr31_human(display_long)|uniprotkb:WDR31(gene name)|psi-mi:WDR31(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483857|imex:IM-22301-1706 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000148225(gene)|ensembl:ENST00000374193(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR040066|refseq:NP_001012361.1|refseq:NP_660284.1|uniprotkb:Q8NA23(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:Cgbv7icdlEKTBS0PGx4/eCPv2I49606 intact-crc:A0B3B36B6754C3AA|rigid:8WFWGJPawyREDWLY6e8tN6AKvno false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8N7A1 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9478080|uniprotkb:B3KXD9|uniprotkb:Q8WYI1|ensembl:ENSP00000352282 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:kldc1_human(display_long)|uniprotkb:KLHDC1(gene name)|psi-mi:KLHDC1(display_short)|uniprotkb:MSTP025(orf name) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483842|imex:IM-22301-1705 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_751943.1|ensembl:ENSG00000197776(gene)|ensembl:ENST00000359332(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q8N7A1(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:J4WCrNJCBtEGJ3t2QmgZ8SUlldU9606 intact-crc:B1BDF86749BD1FC0|rigid:x9v9QOTRHSXimDZhC7o9u7dxuos false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q8NBE8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2512246|ensembl:ENSP00000272797|ensembl:ENSP00000376419|uniprotkb:Q8N9B9|uniprotkb:Q96FT8 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh23_human(display_long)|uniprotkb:KLHL23(gene name)|psi-mi:KLHL23(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483887|imex:IM-22301-1708 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) ensembl:ENSG00000213160(gene)|ensembl:ENST00000272797(transcript)|ensembl:ENST00000392647(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001186219.1|refseq:NP_653312.2|uniprotkb:Q8NBE8(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:KHjH26i26qZE1hlbLvVU+qbSJHk9606 intact-crc:C976C80FA22A3EB8|rigid:cptJ8+Lt8m8fGj/HAu1Lq374ii0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NA75 uniprotkb:Q9Y266 intact:EBI-9478137|ensembl:ENSP00000316496 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:dc4l2_human(display_long)|uniprotkb:DCAF4L2(gene name)|psi-mi:DCAF4L2(display_short)|uniprotkb:WD repeat-containing protein 21C(gene name synonym)|uniprotkb:WDR21C(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483872|imex:IM-22301-1707 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689631.1|ensembl:ENSG00000176566(gene)|ensembl:ENST00000319675(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|uniprotkb:Q8NA75(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:xGkKk/OaiWO5wBKDtB8sNfKj2lg9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:5740527C23200F73|rigid:k2s/2XfnFypM8rbRRA926vXUGKo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NBT0 uniprotkb:Q9Y266 intact:EBI-2557132|uniprotkb:A4FUW4|uniprotkb:E9PFC6|uniprotkb:Q96IK6|uniprotkb:Q2TAK6|uniprotkb:Q0VDF8|uniprotkb:Q9UFJ8|ensembl:ENSP00000296484 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:poc1a_human(display_long)|uniprotkb:WDR51A(gene name synonym)|uniprotkb:WD repeat-containing protein 51A(gene name synonym)|uniprotkb:POC1A(gene name)|psi-mi:POC1A(display_short)|uniprotkb:Pix2(gene name synonym)|uniprotkb:Proteome of centriole protein 1A(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483902|imex:IM-22301-1709 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000164087(gene)|ensembl:ENST00000296484(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0030030"(cell projection organization)|go:"GO:0036064"(ciliary basal body)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|refseq:NP_001155052.1|refseq:NP_001155053.1|refseq:NP_056241.3|uniprotkb:Q8NBT0(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:McHLLJ/7U4ZfJoqMeCmDrxuGOpU9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:B0B449FA0192C01C|rigid:3grmAJXkwSNNQuxcrkO3CNmqJ9c false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8NER5 uniprotkb:B4DYC6 intact:EBI-6423927|ensembl:ENSP00000243349|uniprotkb:Q86UL2|uniprotkb:Q8TBG2|uniprotkb:Q86UL1|uniprotkb:Q4ZFZ8 intact:EBI-9357028 psi-mi:acv1c_human(display_long)|uniprotkb:ACVR1C(gene name)|psi-mi:ACVR1C(display_short)|uniprotkb:ALK7(gene name synonym)|uniprotkb:Activin receptor type IC(gene name synonym)|uniprotkb:Activin receptor-like kinase 7(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483917|imex:IM-22301-1710 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123612(gene)|ensembl:ENST00000243349(transcript)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0009749"(response to glucose)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019838"(growth factor binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0032868"(response to insulin)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0038100"(nodal binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901383"(negative regulation of chorionic trophoblast cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-1181150|reactome:R-HSA-1433617|reactome:R-HSA-1502540|refseq:NP_001104501.1|refseq:NP_001104502.1|refseq:NP_001104503.1|refseq:NP_660302.2|uniprotkb:Q8NER5(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:bZJsAp/xBDeJe/bO8LZndO0Py7s9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:5C55DC50F76AC532|rigid:98I0TXZ4O3us95TdVSGUTEOSPZ8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q8NFJ9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483933|imex:IM-22301-1711 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922|uniprotkb:Q8NFJ9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:D4146D00BC85D5C6|rigid:AlDCSbJxBJvLmDnH5p2YHiVbacg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8NFJ9 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483948|imex:IM-22301-1712 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922|uniprotkb:Q8NFJ9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 intact-crc:C3948792AEDA8291|rigid:OvtrWccxI4/4STLCPsdAcFBF5nk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8NI36 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483963|imex:IM-22301-1713 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1|uniprotkb:Q8NI36(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606 intact-crc:C071C60879B4D520|rigid:RtwW64wL6sewBQbjRrxuXLI0JAA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8TC44 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1176274|ensembl:ENSP00000323302|uniprotkb:G3V1X0 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:poc1b_human(display_long)|uniprotkb:POC1B(gene name)|psi-mi:POC1B(display_short)|uniprotkb:WDR51B(gene name synonym)|uniprotkb:WD repeat-containing protein 51B(gene name synonym)|uniprotkb:Pix1(gene name synonym)|uniprotkb:Proteome of centriole protein 1B(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483978|imex:IM-22301-1714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_758440.1|ensembl:ENSG00000139323(gene)|ensembl:ENST00000313546(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008283"(cell population proliferation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q8TC44|refseq:NP_001186706.1|uniprotkb:Q8TC44(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:wLnp5gzUvx/+G6b2BJUDopNgpOc9606 intact-crc:D95C16D89EB65EE9|rigid:OgVuV2ch9xjT7vICapN735rIu+8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TEB1 uniprotkb:Q9Y266 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484011|imex:IM-22301-1716 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664|uniprotkb:Q8TEB1(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:5D19BECBD685273E|rigid:MIWBhVVN4vE7+HBoPpts20EMTv0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TD19 uniprotkb:Q8WVJ2 intact:EBI-1044009|uniprotkb:Q52LK6|uniprotkb:Q8NCN0|uniprotkb:Q8TCY4|uniprotkb:Q9UPI4|uniprotkb:Q9Y6S4|uniprotkb:Q9Y6S5|uniprotkb:Q9Y6S6|intact:EBI-28978800|ensembl:ENSP00000238616 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:nek9_human(display_long)|uniprotkb:NEK9(gene name)|psi-mi:NEK9(display_short)|uniprotkb:KIAA1995(gene name synonym)|uniprotkb:NEK8(gene name synonym)|uniprotkb:NERCC(gene name synonym)|uniprotkb:Never in mitosis A-related kinase 9(gene name synonym)|uniprotkb:Nercc1 kinase(gene name synonym)|uniprotkb:NimA-related kinase 8(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9483993|imex:IM-22301-1715 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_149107.4|ensembl:ENSG00000119638(gene)|ensembl:ENST00000238616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011009(Protein kinase-like)|interpro:IPR042767|mint:Q8TD19|rcsb pdb:3ZKE|rcsb pdb:3ZKF|reactome:R-HSA-2980767|reactome:R-HSA-3301854|reactome:R-HSA-9648025|ensembl:ENSP00000238616|refseq:NP_001316166.1|refseq:NP_001316167.1|uniprotkb:Q8TD19(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:nH92Hku490dDttw5Akug+NjXRNY9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:3B194E6B71654E8F|rigid:EmeAPSSAzwv8dnhk+5PG26Kz7OQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8WVS4 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2556085|uniprotkb:Q9NW58|ensembl:ENSP00000384290 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dc2i1_human(display_long)|uniprotkb:DYNC2I1(gene name)|psi-mi:DYNC2I1(display_short)|uniprotkb:Dynein 2 intermediate chain 1(gene name synonym)|uniprotkb:WD repeat-containing protein 60(gene name synonym)|uniprotkb:WDR60(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484041|imex:IM-22301-1718 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_060521.4|ensembl:ENSG00000126870(gene)|ensembl:ENST00000407559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005615"(extracellular space)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060271"(cilium assembly)|go:"GO:0097014"(ciliary plasm)|go:"GO:0097542"(ciliary tip)|go:"GO:0097546"(ciliary base)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR042505|rcsb pdb:6RLB|rcsb pdb:6SC2|reactome:R-HSA-5620924|uniprotkb:Q8WVS4(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:F9IgUDyg+GEB56KiQzrr8vsKa4Q9606 intact-crc:7F2D20DF88D699D6|rigid:c8dv8CDRibsyOMgh0bKcoWSdoyQ false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q8WV16 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2559135|uniprotkb:Q96K22|uniprotkb:Q86U31|uniprotkb:Q9Y4P5|uniprotkb:B4DUT6|uniprotkb:Q8IV10|uniprotkb:G3V522|intact:EBI-11038566|ensembl:ENSP00000351147 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dcaf4_human(display_long)|uniprotkb:DCAF4(gene name)|psi-mi:DCAF4(display_short)|uniprotkb:WDR21(gene name synonym)|uniprotkb:WDR21A(gene name synonym)|uniprotkb:WD repeat-containing protein 21A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484026|imex:IM-22301-1717 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_001156980.1|refseq:NP_001156981.1|refseq:NP_056419.2|refseq:NP_851937.1|refseq:NP_851938.2|refseq:XP_016876696.1|refseq:XP_016876697.1|dip:DIP-48761N|ensembl:ENSG00000119599(gene)|ensembl:ENST00000358377(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:3I8C|reactome:R-HSA-8951664|uniprotkb:Q8WV16(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:o0rADLH1i0ZHAC/i224zAJASd4c9606 intact-crc:301DEF6ADB88F866|rigid:+/Sr+h6/iYHDzMteB7WBs0nxzCg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WZ60 uniprotkb:Q9Y266 intact:EBI-6426464|ensembl:ENSP00000341342|uniprotkb:D3DNS8|uniprotkb:Q8N5I1|uniprotkb:B2RB31|uniprotkb:Q8N892 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:klhl6_human(display_long)|uniprotkb:KLHL6(gene name)|psi-mi:KLHL6(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484071|imex:IM-22301-1720 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172578(gene)|ensembl:ENST00000341319(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR029851|refseq:NP_569713.2|uniprotkb:Q8WZ60(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3HSrMq8OrULpGu1i53jA+tFs+xA9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:AAD8DEB319A4C76A|rigid:tit7Svduu/WeeCwPEbOvp4PJIiQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WZ60 uniprotkb:Q8IVD9 intact:EBI-6426464|ensembl:ENSP00000341342|uniprotkb:D3DNS8|uniprotkb:Q8N5I1|uniprotkb:B2RB31|uniprotkb:Q8N892 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klhl6_human(display_long)|uniprotkb:KLHL6(gene name)|psi-mi:KLHL6(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484056|imex:IM-22301-1719 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172578(gene)|ensembl:ENST00000341319(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR029851|refseq:NP_569713.2|uniprotkb:Q8WZ60(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3HSrMq8OrULpGu1i53jA+tFs+xA9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:1A49BEE9C9C32A94|rigid:KqaHJK4J8WsY4YvlofBNo97UUUM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q969H0 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-359574|uniprotkb:Q68DR0|uniprotkb:Q96A16|uniprotkb:Q96LE0|uniprotkb:Q96RI2|ensembl:ENSP00000281708|ensembl:ENSP00000474725|ensembl:ENSP00000474971|uniprotkb:Q9NUX6|uniprotkb:B7ZLP9 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:fbxw7_human(display_long)|uniprotkb:FBXW7(gene name)|psi-mi:FBXW7(display_short)|uniprotkb:FBW7(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:SEL10(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 7(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym)|uniprotkb:Archipelago homolog(gene name synonym)|uniprotkb:SEL-10(gene name synonym)|uniprotkb:hCdc4(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484102|imex:IM-22301-1722 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010868"(negative regulation of triglyceride biosynthetic process)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030324"(lung development)|go:"GO:0030332"(cyclin binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000109670(gene)|ensembl:ENST00000281708(transcript)|ensembl:ENST00000603548(transcript)|ensembl:ENST00000603841(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007219"(Notch signaling pathway)|refseq:NP_001013433.1|refseq:NP_060785.2|refseq:NP_361014.1|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2000639"(negative regulation of SREBP signaling pathway)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR001680(WD40 repeat)|go:"GO:0050821"(protein stabilization)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:5IBK|rcsb pdb:5V4B|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2894862|reactome:R-HSA-390471|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9604323|reactome:R-HSA-983168|interpro:IPR001810(Cyclin-like F-box)|refseq:XP_011530385.1|refseq:XP_011530386.1|refseq:XP_011530387.1|go:"GO:0050816"(phosphothreonine residue binding)|refseq:XP_016863851.1|dip:DIP-27613N|uniprotkb:Q969H0(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:nTHe/NUeMqEs6y00A9rvRHTUMfk9606 intact-crc:962852B8ED5F639C|rigid:qMZu+IFqxhK5XV3LG0AMxfCvGjI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92834 uniprotkb:B4DYC6 intact:EBI-6558417|ensembl:ENSP00000343671|uniprotkb:B1ARN3|uniprotkb:E9PE28|uniprotkb:O00702|uniprotkb:O00737|uniprotkb:Q3KN84|uniprotkb:Q8N5T6|uniprotkb:Q93039|uniprotkb:Q9HD29|uniprotkb:Q9UMR1|intact:EBI-12703128|intact:EBI-16431503 intact:EBI-9357028 psi-mi:rpgr_human(display_long)|uniprotkb:RPGR(gene name)|psi-mi:RPGR(display_short)|uniprotkb:RP3(gene name synonym)|uniprotkb:XLRP3(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484086|imex:IM-22301-1721 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016885199.1|ensembl:ENSG00000156313(gene)|ensembl:ENST00000339363(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007601"(visual perception)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036126"(sperm flagellum)|go:"GO:0042073"(intraciliary transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060271"(cilium assembly)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|rcsb pdb:4JHN|rcsb pdb:4JHP|rcsb pdb:4QAM|refseq:NP_000319.1|refseq:NP_001030025.1|uniprotkb:Q92834(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:yG3e/pDbkwML2e7J8BMMXY/EVPM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:ADD8EFD6A971BCB3|rigid:MhepsbYyh5GW5+a5Mtmazb/V21E false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q96FV0 intact:EBI-9357028 intact:EBI-9478401|uniprotkb:A8K9Q0|ensembl:ENSP00000269025 psi-mi:b4dyc6_human(display_long) psi-mi:lrc46_human(display_long)|uniprotkb:LRRC46(gene name)|psi-mi:LRRC46(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484132|imex:IM-22301-1724 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) ensembl:ENSP00000269025|refseq:NP_219481.1|ensembl:ENSG00000141294(gene)|ensembl:ENST00000269025(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|uniprotkb:Q96FV0(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:kdQG+JlTEb8HhsQe2AJ9Ki+sjFg9606 intact-crc:BF4C67B15AB315DB|rigid:8aG3gFQNe/8z76aQqQHCYPjm7n0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96CT2 uniprotkb:Q8IVD9 intact:EBI-6426370|ensembl:ENSP00000420659|uniprotkb:Q8N388|uniprotkb:Q96BF0|uniprotkb:Q96PW7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh29_human(display_long)|uniprotkb:KLHL29(gene name)|psi-mi:KLHL29(display_short)|uniprotkb:KBTBD9(gene name synonym)|uniprotkb:KIAA1921(gene name synonym)|uniprotkb:Kelch repeat and BTB domain-containing protein 9(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484117|imex:IM-22301-1723 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000119771(gene)|ensembl:ENST00000486442(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|refseq:XP_006711992.1|refseq:NP_443152.1|refseq:XP_016858753.1|uniprotkb:Q96CT2(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:X3JAPBONnHtcVpxR86+n0Pgl5yg9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:A56CB581A68B19EB|rigid:g2a0tyrlBLLgc0uJsLVcRfKHZQg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96G42 uniprotkb:Q8IVD9 intact:EBI-9478422|ensembl:ENSP00000379034 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:kld7b_human(display_long)|uniprotkb:KLHDC7B(gene name)|psi-mi:KLHDC7B(display_short) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484148|imex:IM-22301-1725 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000379034|refseq:NP_612442.2|ensembl:ENSG00000130487(gene)|ensembl:ENST00000395676(transcript)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q96G42(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:xUwBJmqf4PK0NHysANEApHvQkxM9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:57711B123BCB1E04|rigid:WaCBez6TNOlu1tfbBYdaEgH+tkg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96J01 uniprotkb:Q8WVJ2 intact:EBI-2510823|ensembl:ENSP00000265097|uniprotkb:Q6NZ53 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:thoc3_human(display_long)|uniprotkb:THOC3(gene name)|psi-mi:THOC3(display_short)|uniprotkb:TEX1 homolog(gene name synonym)|uniprotkb:hTREX45(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484198|imex:IM-22301-1728 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000051596(gene)|ensembl:ENST00000265097(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|interpro:IPR040132|mint:Q96J01|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_115737.1|uniprotkb:Q96J01(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ENG6Gf3Q6WsTn5qkASarueRR+qc9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:C89E2CF61E39D2BB|rigid:rMzIpndHaN/6fpm3ikk8/ZmjAu0 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96II8 uniprotkb:B4DYC6 intact:EBI-8795942|uniprotkb:B4E0T7|intact:EBI-10963906|uniprotkb:Q9NT52|uniprotkb:Q96FP9|ensembl:ENSP00000393579 intact:EBI-9357028 psi-mi:lrch3_human(display_long)|uniprotkb:LRCH3(gene name)|psi-mi:LRCH3(display_short)|uniprotkb:Leucine-rich repeat and calponin homology domain-containing protein 3(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484182|imex:IM-22301-1727 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005269419.1|refseq:NP_116162.1|refseq:XP_006713854.1|ensembl:ENSG00000186001(gene)|ensembl:ENST00000425562(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032185"(septin cytoskeleton organization)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872|uniprotkb:Q96II8(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:hb9NKXgACuzQk1py0w1k4DcE0h09606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:C97A5BD4E7E08108|rigid:PG6unzYekT1fNkVt9WiZGrsCB7w false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q96II5 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9383168|uniprotkb:A6NIT1 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q96ii5_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484163|imex:IM-22301-1726 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|refseq:NP_001243125.1|interpro:IPR029071|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|uniprotkb:Q96II5(identity)|human orfeome collection:4651(identity)|entrezgene/locuslink:369(identity)|ddbj/embl/genbank:BC007514 psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:iaSbMcS/CaA7wIsW4aBMZ14DAiQ9606 intact-crc:814A3FC3AD77B6CB|rigid:RTvDjXCgiiTLHi5u0HP2IWiydyI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96M69 uniprotkb:B4DYC6 intact:EBI-9478535|uniprotkb:Q2M3I1|ensembl:ENSP00000285928 intact:EBI-9357028 psi-mi:lrguk_human(display_long)|uniprotkb:LRGUK(gene name)|psi-mi:LRGUK(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484244|imex:IM-22301-1731 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_653249.1|interpro:IPR027417|interpro:IPR032675|ensembl:ENSG00000155530(gene)|ensembl:ENST00000285928(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0035082"(axoneme assembly)|go:"GO:0042995"(cell projection)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|uniprotkb:Q96M69(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Jb5TslAs9nplbT4CAmvObB9F2Qg9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:CD6FF2841B6EA7F0|rigid:Y9CPD43G2c15ijpfP6v2Oa7ZcGA false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96L50 uniprotkb:B4DYC6 intact:EBI-2510106|uniprotkb:B4DDE0|ensembl:ENSP00000298288|uniprotkb:A5D6X3|uniprotkb:Q52M24|uniprotkb:Q8N6H9|uniprotkb:Q86SZ1 intact:EBI-9357028 psi-mi:llr1_human(display_long)|uniprotkb:LRR1(gene name)|psi-mi:LRR1(display_short)|uniprotkb:PPIL5(gene name synonym)|uniprotkb:LRR-repeat protein 1(gene name synonym)|uniprotkb:4-1BB-mediated-signaling molecule(gene name synonym)|uniprotkb:4-1BBlrr(gene name synonym)|uniprotkb:Peptidylprolyl isomerase-like 5(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484228|imex:IM-22301-1730 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165501(gene)|ensembl:ENST00000298288(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR025875|interpro:IPR032675|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689542.2|refseq:NP_982292.1|uniprotkb:Q96L50(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:7znZddT/rr1wCuorp9l6jxzsujE9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:E5B6402DBF20942E|rigid:NA3wxXpFL/EFtmXniGMYYsFNXbE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q96KV7 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9478492|uniprotkb:Q96PW4|uniprotkb:Q8NBB8|uniprotkb:Q6ZMS1|uniprotkb:Q6P048|uniprotkb:Q0VA87|uniprotkb:Q0VA88|uniprotkb:Q8N221|uniprotkb:Q96S18|uniprotkb:Q6ZTH1|uniprotkb:Q8N202|ensembl:ENSP00000293879|intact:EBI-28979154 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:wdr90_human(display_long)|uniprotkb:WDR90(gene name)|psi-mi:WDR90(display_short)|uniprotkb:C16orf15(gene name synonym)|uniprotkb:C16orf16(gene name synonym)|uniprotkb:C16orf17(gene name synonym)|uniprotkb:C16orf18(gene name synonym)|uniprotkb:C16orf19(gene name synonym)|uniprotkb:KIAA1924(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484213|imex:IM-22301-1729 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSP00000293879|ensembl:ENST00000315764|ensembl:ENSP00000322808|refseq:NP_660337.3|ensembl:ENSG00000161996(gene)|ensembl:ENST00000293879(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0060271"(cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR007714(Protein of unknown function DUF667)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030466|interpro:IPR036322|uniprotkb:Q96KV7(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:jaNe0JNgm1JZ2ds5GZGtLHsz3UY9606 intact-crc:18E1B8DCA34DA96D|rigid:voJGn9kNYGKTQHZhtVTbILkgwi8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q96P53 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9478589|uniprotkb:Q96CS1|uniprotkb:B1AL86|ensembl:ENSP00000298125 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:wdfy2_human(display_long)|uniprotkb:WDFY2(gene name)|psi-mi:WDFY2(display_short)|uniprotkb:WD40- and FYVE domain-containing protein 2(gene name synonym)|uniprotkb:WDF2(gene name synonym)|uniprotkb:ZFYVE22(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 22(gene name synonym)|uniprotkb:Propeller-FYVE protein(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484290|imex:IM-22301-1734 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_443182.1|ensembl:ENSG00000139668(gene)|ensembl:ENST00000298125(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005769"(early endosome)|go:"GO:0031982"(vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR001680(WD40 repeat)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR042234|uniprotkb:Q96P53(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:23oniGRlOjmjbiXp87y6KjKztKc9606 intact-crc:FB112751F1627B1C|rigid:DIAcs18oEfA+LDT81ZuT+91OrME false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96NJ5 uniprotkb:Q8IVD9 intact:EBI-6426390|ensembl:ENSP00000358265|uniprotkb:B7Z346|uniprotkb:B7Z4E2|uniprotkb:Q5THT0|uniprotkb:Q96PY7|uniprotkb:E1P528 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh32_human(display_long)|uniprotkb:KLHL32(gene name)|psi-mi:KLHL32(display_short)|uniprotkb:BKLHD5(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 5(gene name synonym)|uniprotkb:KIAA1900(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484275|imex:IM-22301-1733 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273179.1|refseq:NP_001273180.1|refseq:NP_001273183.1|refseq:NP_001310184.1|ensembl:ENSG00000186231(gene)|ensembl:ENST00000369261(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030570|refseq:NP_001310185.1|refseq:NP_001310186.1|refseq:NP_001310188.1|refseq:NP_001310189.1|refseq:NP_001310190.1|refseq:NP_001310191.1|refseq:NP_001310192.1|refseq:NP_001310193.1|refseq:NP_001310181.1|refseq:NP_001310182.1|refseq:NP_001310183.1|refseq:NP_443136.2|uniprotkb:Q96NJ5(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:E+cmKJjMNb4uDT3Rf8eZmauNDdc9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:9C5A59421B93E2CD|rigid:UkRUyKucZD5E+jdZYR3wCLT30/k false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96M94 uniprotkb:Q8IVD9 intact:EBI-2510129|ensembl:ENSP00000332791|uniprotkb:Q9C0I6|uniprotkb:Q32MN3|uniprotkb:Q96BM6|uniprotkb:Q8NDA3 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh15_human(display_long)|uniprotkb:KLHL15(gene name)|psi-mi:KLHL15(display_short)|uniprotkb:KIAA1677(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484260|imex:IM-22301-1732 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000174010(gene)|ensembl:ENST00000328046(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030597|refseq:NP_085127.2|refseq:XP_006724581.1|uniprotkb:Q96M94(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Xkm72585iSVnSMqN1b0XM79Pd2g9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:7996BAABA554ECCB|rigid:0eZL5cPccUSJORq7yomCxTAuAO4 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q96Q42 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1044902|uniprotkb:Q8N1E0|uniprotkb:Q96PC4|uniprotkb:Q96Q41|uniprotkb:Q9H973|uniprotkb:Q9HCK9|uniprotkb:Q53TT1|uniprotkb:Q53TV2|ensembl:ENSP00000264276|ensembl:ENSP00000505043|ensembl:ENSP00000505092|ensembl:ENSP00000505187|ensembl:ENSP00000505218 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:als2_human(display_long)|uniprotkb:Amyotrophic lateral sclerosis 2 protein(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein(gene name synonym)|uniprotkb:ALS2(gene name)|psi-mi:ALS2(display_short)|uniprotkb:KIAA1563(gene name synonym)|uniprotkb:ALS2CR6(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484337|imex:IM-22301-1737 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_001129217.1|refseq:NP_065970.2|interpro:IPR037191|reactome:R-HSA-8876198|reactome:R-HSA-9013149|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR003123(Vacuolar sorting protein 9)|interpro:IPR003409(MORN motif)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|ensembl:ENSG00000003393(gene)|ensembl:ENST00000264276(transcript)|ensembl:ENST00000679435(transcript)|ensembl:ENST00000679516(transcript)|ensembl:ENST00000680163(transcript)|ensembl:ENST00000680861(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007032"(endosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008104"(protein localization)|go:"GO:0008219"(cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042802"(identical protein binding)|ensembl:ENSP00000264276|ensembl:ENST00000409632|ensembl:ENSP00000386384|ensembl:ENST00000467448|ensembl:ENSP00000429223|ensembl:ENSP00000505218|ensembl:ENST00000679503|ensembl:ENSP00000505968|ensembl:ENSP00000505187|ensembl:ENSP00000505092|ensembl:ENST00000680188|ensembl:ENSP00000505665|ensembl:ENSP00000505043|refseq:XP_006712717.1|uniprotkb:Q96Q42(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:/CbIkwBlU9LPad9mVvtQAgsHwmk9606 intact-crc:C613BECEA9732BD3|rigid:0zkCi1kaAP9EYzWVFZUc7aKcD6c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96Q40 uniprotkb:Q16543 intact:EBI-1051975|uniprotkb:Q53TV1|uniprotkb:Q4ZG86|uniprotkb:Q6ZMR9|uniprotkb:Q8IUP1|uniprotkb:B8ZZX0|uniprotkb:C9J1N8|uniprotkb:C9K003|uniprotkb:A8K8R9|uniprotkb:F8W6H8|ensembl:ENSP00000498608 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:cdk15_human(display_long)|uniprotkb:ALS2CR7(gene name synonym)|uniprotkb:Serine/threonine-protein kinase ALS2CR7(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein(gene name synonym)|uniprotkb:CDK15(gene name)|psi-mi:CDK15(display_short)|uniprotkb:PFTK2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PFTAIRE-2(gene name synonym)|uniprotkb:Cell division protein kinase 15(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484321|imex:IM-22301-1736 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001248364.1|refseq:NP_631897.1|refseq:NP_001248365.1|refseq:XP_005246838.1|refseq:XP_005246839.1|ensembl:ENST00000652192(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042761|ensembl:ENSG00000138395(gene)|uniprotkb:Q96Q40(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ceURrVNJCJYYLumA/a7VLDbE1Eg9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:30873162C8A2F7C4|rigid:YsgWn0kePZSdQ7/ZtKDWJe2bjOI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96Q40 uniprotkb:Q16543 intact:EBI-1051975|uniprotkb:Q53TV1|uniprotkb:Q4ZG86|uniprotkb:Q6ZMR9|uniprotkb:Q8IUP1|uniprotkb:B8ZZX0|uniprotkb:C9J1N8|uniprotkb:C9K003|uniprotkb:A8K8R9|uniprotkb:F8W6H8|ensembl:ENSP00000498608 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:cdk15_human(display_long)|uniprotkb:ALS2CR7(gene name synonym)|uniprotkb:Serine/threonine-protein kinase ALS2CR7(gene name synonym)|uniprotkb:Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein(gene name synonym)|uniprotkb:CDK15(gene name)|psi-mi:CDK15(display_short)|uniprotkb:PFTK2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PFTAIRE-2(gene name synonym)|uniprotkb:Cell division protein kinase 15(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484305|imex:IM-22301-1735 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001248364.1|refseq:NP_631897.1|refseq:NP_001248365.1|refseq:XP_005246838.1|refseq:XP_005246839.1|ensembl:ENST00000652192(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042761|ensembl:ENSG00000138395(gene)|uniprotkb:Q96Q40(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ceURrVNJCJYYLumA/a7VLDbE1Eg9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:0BFC52F40FB2EAA7|rigid:YsgWn0kePZSdQ7/ZtKDWJe2bjOI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RY7 uniprotkb:Q9Y266 intact:EBI-308494|uniprotkb:O60332|uniprotkb:Q9UG52|uniprotkb:A2A2A8|uniprotkb:D3DU75|ensembl:ENSP00000406012 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:if140_human(display_long)|uniprotkb:IFT140(gene name)|psi-mi:IFT140(display_short)|uniprotkb:KIAA0590(gene name synonym)|uniprotkb:WDTC2(gene name synonym)|uniprotkb:WD and tetratricopeptide repeats protein 2(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484372|imex:IM-22301-1739 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055529.2|ensembl:ENSG00000187535(gene)|ensembl:ENST00000426508(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0021532"(neural tube patterning)|go:"GO:0030991"(intraciliary transport particle A)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-5610787|reactome:R-HSA-5620924|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|refseq:XP_006721053.1|refseq:XP_006721054.1|refseq:XP_016879399.1|uniprotkb:Q96RY7(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LQ8zt35IhriM/UbIOoQXk72oLAQ9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:B2365E66BE80F139|rigid:ot0cTvUPfnPHVjUHpWagPza+uvw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96QS6 uniprotkb:Q16543 intact:EBI-6424813|ensembl:ENSP00000276616|uniprotkb:A0AV22 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:kpsh2_human(display_long)|uniprotkb:PSKH2(gene name)|psi-mi:PSKH2(display_short)|uniprotkb:Protein serine kinase H2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484353|imex:IM-22301-1738 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147613(gene)|ensembl:ENST00000276616(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|refseq:NP_149117.1|uniprotkb:Q96QS6(identity)|human orfeome collection:54299(identity)|entrezgene/locuslink:85481(identity)|ddbj/embl/genbank:BC126180 refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:tcOISTrdxixiVCnoNMW/knj1Vmo9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:4FE024CCE6FE8717|rigid:rmaNCXxTxJIWppCfSVXdiGOnyPM false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BV99 uniprotkb:B4DYC6 intact:EBI-2350424|uniprotkb:B3KUW0|uniprotkb:D3DWY8|ensembl:ENSP00000339047|ensembl:ENSP00000352642|ensembl:ENSP00000420560 intact:EBI-9357028 psi-mi:lrc61_human(display_long)|uniprotkb:LRRC61(gene name)|psi-mi:LRRC61(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484434|imex:IM-22301-1743 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006716158.1|refseq:NP_001136400.1|refseq:NP_076431.1|ensembl:ENSG00000127399(gene)|ensembl:ENST00000323078(transcript)|ensembl:ENST00000359623(transcript)|ensembl:ENST00000493307(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|uniprotkb:Q9BV99(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:LIU9hAGgEAFLuJqz4NrHn6a0vFc9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:67D80D53697DBAFC|rigid:5FEOewTlbTUoCVKYYpEbwzTjkOE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9BTT6 intact:EBI-9357028 intact:EBI-713489|uniprotkb:Q9HAC0|uniprotkb:Q9NVF1|ensembl:ENSP00000359925|uniprotkb:Q5TGN3 psi-mi:b4dyc6_human(display_long) psi-mi:lrrc1_human(display_long)|uniprotkb:LAP and no PDZ protein(gene name synonym)|uniprotkb:LANO adapter protein(gene name synonym)|uniprotkb:LRRC1(gene name)|psi-mi:LRRC1(display_short)|uniprotkb:LANO(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484418|imex:IM-22301-1742 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) ensembl:ENSG00000137269(gene)|ensembl:ENST00000370888(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-9696270|refseq:NP_060684.4|refseq:XP_011513028.1|uniprotkb:Q9BTT6(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:FJ/8+gehIT2j2bJ8gYpkDht+//I9606 intact-crc:64F75DDDFDC485ED|rigid:1IzXi7VENLCakTouyVjcOBxEeZA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ87 uniprotkb:Q9Y266 intact:EBI-9478706|uniprotkb:A1L4B3|ensembl:ENSP00000328879|ensembl:ENSP00000347289|ensembl:ENSP00000372499 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:tbl1y_human(display_long)|uniprotkb:TBL1Y(gene name)|psi-mi:TBL1Y(display_short)|uniprotkb:TBL1(gene name synonym)|uniprotkb:Transducin beta-like protein 1Y(gene name synonym)|uniprotkb:Transducin-beta-like protein 1, Y-linked(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484403|imex:IM-22301-1741 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_150600.1|refseq:NP_599020.1|refseq:NP_599021.1|ensembl:ENSG00000092377(gene)|ensembl:ENST00000346432(transcript)|ensembl:ENST00000355162(transcript)|ensembl:ENST00000383032(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016575"(histone deacetylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|uniprotkb:Q9BQ87(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:xPndnDqlbd41q7zO8bLh7CSeOmc9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:892E6E9634D25110|rigid:f4s0b+k3Kfh7tbwoBHs79rbqM8U false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q99558 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-358011|uniprotkb:Q8IYN1|uniprotkb:A8K2D8|uniprotkb:D3DX67|ensembl:ENSP00000478552|ensembl:ENSP00000480974|ensembl:ENSP00000482657 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:m3k14_human(display_long)|uniprotkb:MAP3K14(gene name)|psi-mi:MAP3K14(display_short)|uniprotkb:NIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase NIK(gene name synonym)|uniprotkb:NF-kappa-beta-inducing kinase(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484387|imex:IM-22301-1740 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_003945.2|refseq:XP_011523743.1|dip:DIP-27522N|ensembl:ENSG00000006062(gene)|ensembl:ENST00000344686(transcript)|ensembl:ENST00000376926(transcript)|ensembl:ENST00000617331(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051607"(defense response to virus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017425(Mitogen-activated protein kinase kinase kinase 14)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042787|mint:Q99558|rcsb pdb:4DN5|rcsb pdb:4G3D|rcsb pdb:4IDT|rcsb pdb:4IDV|rcsb pdb:6WPP|rcsb pdb:6Z1Q|rcsb pdb:6Z1T|reactome:R-HSA-389357|reactome:R-HSA-5607761|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5676594|uniprotkb:Q99558(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:GBmoUEm+pGubNnnauGgKgMyeiqA9606 intact-crc:A06CC3465343AB43|rigid:H3fs/fKdISV9f6zTB851doC5Gbo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BYS8 uniprotkb:B4DYC6 intact:EBI-5665279|uniprotkb:Q96LT5|uniprotkb:B2RDQ7|ensembl:ENSP00000296144|ensembl:ENSP00000379241|ensembl:ENSP00000507018 intact:EBI-9357028 psi-mi:lrrc2_human(display_long)|uniprotkb:LRRC2(gene name)|psi-mi:LRRC2(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484481|imex:IM-22301-1746 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532412.1|refseq:NP_078788.2|ensembl:ENSG00000163827(gene)|ensembl:ENST00000296144(transcript)|ensembl:ENST00000395905(transcript)|ensembl:ENST00000682605(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|uniprotkb:Q9BYS8(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:Jj3arKY4upKrAAdUsiHfXgvr/GY9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:A97503604CBC749D|rigid:R1NB4AF69o1EtKQ68R8qSG4MySY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9BXM7 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2846068|uniprotkb:Q8N6T9|uniprotkb:Q8NBU3|uniprotkb:Q96DE4|ensembl:ENSP00000364204 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:pink1_human(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484465|imex:IM-22301-1745 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_115785.1|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903147"(negative regulation of autophagy of mitochondrion)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903751"(negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:1903852"(positive regulation of cristae formation)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904544"(positive regulation of free ubiquitin chain polymerization)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904841"(TORC2 complex binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR040110|reactome:R-HSA-5205685|reactome:R-HSA-9614657|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010857"(calcium-dependent protein kinase activity)|go:"GO:0010952"(positive regulation of peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016301"(kinase activity)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038203"(TORC2 signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0005743"(mitochondrial inner membrane)|dip:DIP-29427N|uniprotkb:Q9BXM7(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:PL0FnTaDke9w5FQlThTKmye/phs9606 intact-crc:D341CA5A97202184|rigid:NA0wedEPJ9/+sxm5PB7LXujZ1fI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9BVC4 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1387471|intact:EBI-1567843|uniprotkb:Q5M800|uniprotkb:Q86Y18|uniprotkb:Q8WUI5|uniprotkb:Q9HA66|uniprotkb:Q9UJV6|uniprotkb:B4DY00|uniprotkb:B3KMM4|uniprotkb:D3DU88|ensembl:ENSP00000380313|ensembl:ENSP00000455046|ensembl:ENSP00000456405|ensembl:ENSP00000457870 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:lst8_human(display_long)|uniprotkb:MLST8(gene name)|psi-mi:MLST8(display_short)|uniprotkb:GBL(gene name synonym)|uniprotkb:G protein beta subunit-like(gene name synonym)|uniprotkb:LST8(gene name synonym)|uniprotkb:Mammalian lethal with SEC13 protein 8(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484450|imex:IM-22301-1744 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_001186102.1|refseq:NP_001186103.1|refseq:NP_001186104.1|refseq:NP_071767.3|refseq:XP_016879037.1|refseq:XP_016879038.1|dip:DIP-39481N|ensembl:ENSG00000167965(gene)|ensembl:ENST00000397124(transcript)|ensembl:ENST00000564088(transcript)|ensembl:ENST00000565250(transcript)|ensembl:ENST00000569417(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031929"(TOR signaling)|go:"GO:0031931"(TORC1 complex)|go:"GO:0031932"(TORC2 complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR037588|mint:Q9BVC4|rcsb pdb:4JSN|rcsb pdb:4JSP|rcsb pdb:4JSV|rcsb pdb:4JSX|rcsb pdb:4JT5|rcsb pdb:4JT6|rcsb pdb:5FLC|rcsb pdb:5H64|rcsb pdb:5WBU|rcsb pdb:5WBY|rcsb pdb:5ZCS|rcsb pdb:6BCU|rcsb pdb:6BCX|rcsb pdb:6SB0|rcsb pdb:6SB2|rcsb pdb:6ZWM|rcsb pdb:6ZWO|reactome:R-HSA-1257604|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-3371571|reactome:R-HSA-380972|reactome:R-HSA-389357|reactome:R-HSA-5218920|reactome:R-HSA-5628897|reactome:R-HSA-5674400|reactome:R-HSA-6804757|reactome:R-HSA-8943724|reactome:R-HSA-9639288|uniprotkb:Q9BVC4(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:BQek96xYe/1IaE8vgX3Uvl9vkCc9606 intact-crc:D08D3EA7FF2373B6|rigid:1ueQ9ZrlCkie4RbevD20U0wXSL8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9C0H6 uniprotkb:Q8WVJ2 intact:EBI-9478822|uniprotkb:B2RTW2|uniprotkb:Q9Y3J5|ensembl:ENSP00000362211|ensembl:ENSP00000498718 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:klhl4_human(display_long)|uniprotkb:KLHL4(gene name)|psi-mi:KLHL4(display_short)|uniprotkb:KIAA1687(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484527|imex:IM-22301-1749 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061990.2|refseq:NP_476503.1|ensembl:ENSG00000102271(gene)|ensembl:ENST00000373119(transcript)|ensembl:ENST00000652270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q9C0H6(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mSqhmsHz+jhh8ZMQoIWJeSm/ILk9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:F56BC50AF47BB803|rigid:AphOP8o4BBwQ7yQtmLKWyJzBV0s false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9C0H6 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-9478822|uniprotkb:B2RTW2|uniprotkb:Q9Y3J5|ensembl:ENSP00000362211|ensembl:ENSP00000498718 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klhl4_human(display_long)|uniprotkb:KLHL4(gene name)|psi-mi:KLHL4(display_short)|uniprotkb:KIAA1687(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484512|imex:IM-22301-1748 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_061990.2|refseq:NP_476503.1|ensembl:ENSG00000102271(gene)|ensembl:ENST00000373119(transcript)|ensembl:ENST00000652270(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0034451"(centriolar satellite)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|uniprotkb:Q9C0H6(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:mSqhmsHz+jhh8ZMQoIWJeSm/ILk9606 intact-crc:617378676D5AF0FD|rigid:CVDzbaJZEZujcg08nNnzeZCuVcE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9C0C7 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484497|imex:IM-22301-1747 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N|uniprotkb:Q9C0C7(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:37B379654E6D3704|rigid:y66NVjKHPLS6AjVLtNvDoO3Vhug false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9GZS3 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484558|imex:IM-22301-1751 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N|uniprotkb:Q9GZS3(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:B74FC91041AC14CD|rigid:0ufcmXyu5qJ3epgeuLFIGuC3qI0 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9C0I9 intact:EBI-9357028 intact:EBI-9478861|uniprotkb:Q86XT5|uniprotkb:Q5SZH9|uniprotkb:A6NKD3|uniprotkb:Q5SZH6|uniprotkb:A6NE72|uniprotkb:Q5SZH8|uniprotkb:A6NJB4|uniprotkb:Q8NA21|uniprotkb:Q8N7C8|uniprotkb:D3DRH0|ensembl:ENSP00000357602|ensembl:ENSP00000357603 psi-mi:b4dyc6_human(display_long) psi-mi:lrc27_human(display_long)|uniprotkb:LRRC27(gene name)|psi-mi:LRRC27(display_short)|uniprotkb:KIAA1674(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484542|imex:IM-22301-1750 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:XP_011538510.1|refseq:XP_016872181.1|refseq:NP_001137229.1|refseq:NP_001137230.1|refseq:NP_001137231.1|refseq:NP_085129.1|refseq:XP_006718046.1|ensembl:ENSG00000148814(gene)|ensembl:ENST00000368613(transcript)|ensembl:ENST00000368614(transcript)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|uniprotkb:Q9C0I9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:vQTYTG1himsiRV385H0Vdco8J549606 intact-crc:064CC1DE2133394E|rigid:IAJX3nbNCabwN4fWNXastuZRCPg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0H3 uniprotkb:Q8IVD9 intact:EBI-6426337|ensembl:ENSP00000336800|uniprotkb:B3KRT7|uniprotkb:B2RDH2 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh25_human(display_long)|uniprotkb:KLHL25(gene name)|psi-mi:KLHL25(display_short)|uniprotkb:ENC2(gene name synonym)|uniprotkb:Ectoderm-neural cortex protein 2(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484590|imex:IM-22301-1753 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183655(gene)|ensembl:ENST00000337975(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030565|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_071925.2|uniprotkb:Q9H0H3(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+NvA95JXrSCQdgw0qWO1XhH4YCo9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:5ECF0596D9D26D72|rigid:CL2NU3ZVzl4rsn7Pk5J+dNHQQdI false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H0H3 uniprotkb:B4DYC6 intact:EBI-6426337|ensembl:ENSP00000336800|uniprotkb:B3KRT7|uniprotkb:B2RDH2 intact:EBI-9357028 psi-mi:klh25_human(display_long)|uniprotkb:KLHL25(gene name)|psi-mi:KLHL25(display_short)|uniprotkb:ENC2(gene name synonym)|uniprotkb:Ectoderm-neural cortex protein 2(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484574|imex:IM-22301-1752 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183655(gene)|ensembl:ENST00000337975(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030565|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_071925.2|uniprotkb:Q9H0H3(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:+NvA95JXrSCQdgw0qWO1XhH4YCo9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:326065ED1B9597EF|rigid:Ge9uD71J6eTbMvIwzfRyyWvEFlo false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9H511 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9478985|uniprotkb:B2RP49|uniprotkb:A6N9J2|ensembl:ENSP00000359942|ensembl:ENSP00000384644 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:klh31_human(display_long)|uniprotkb:KLHL31(gene name)|psi-mi:KLHL31(display_short)|uniprotkb:BKLHD6(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 6(gene name synonym)|uniprotkb:KBTBD1(gene name synonym)|uniprotkb:KLHL(gene name synonym)|uniprotkb:Kelch repeat and BTB domain-containing protein 1(gene name synonym)|uniprotkb:Kelch-like protein KLHL(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484653|imex:IM-22301-1757 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:XP_016866347.1|refseq:NP_001003760.2|refseq:XP_005249164.1|ensembl:ENSG00000124743(gene)|ensembl:ENST00000370905(transcript)|ensembl:ENST00000407079(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0046329"(negative regulation of JNK cascade)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030604|uniprotkb:Q9H511(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:9fTrwJ/iMXKix0KBl6/1F2QbKu49606 intact-crc:F51278411EC13196|rigid:llHafHxcOMWUcrUI+EWpMxb5XLk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H2C0 uniprotkb:Q8IVD9 intact:EBI-764342|ensembl:ENSP00000497351 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:gan_human(display_long)|uniprotkb:Kelch-like protein 16(gene name synonym)|uniprotkb:GAN(gene name)|psi-mi:GAN(display_short)|uniprotkb:GAN1(gene name synonym)|uniprotkb:KLHL16(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484638|imex:IM-22301-1756 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071324.1|ensembl:ENSG00000261609(gene)|ensembl:ENST00000648994(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030579|mint:Q9H2C0|rcsb pdb:2PPI|rcsb pdb:3HVE|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9H2C0(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dpwb1OLDaSeParbSZnR8pjveyLk9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:777F601958557745|rigid:YWdZAVuIq8ybJP7DHxorz7VckNY false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9H2C0 intact:EBI-9357028 intact:EBI-764342|ensembl:ENSP00000497351 psi-mi:b4dyc6_human(display_long) psi-mi:gan_human(display_long)|uniprotkb:Kelch-like protein 16(gene name synonym)|uniprotkb:GAN(gene name)|psi-mi:GAN(display_short)|uniprotkb:GAN1(gene name synonym)|uniprotkb:KLHL16(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484622|imex:IM-22301-1755 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_071324.1|ensembl:ENSG00000261609(gene)|ensembl:ENST00000648994(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030579|mint:Q9H2C0|rcsb pdb:2PPI|rcsb pdb:3HVE|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9H2C0(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:dpwb1OLDaSeParbSZnR8pjveyLk9606 intact-crc:E171C3E359829619|rigid:pCjBPPJA7SeUTBQ3mR7AVzEppcM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H1Z4 uniprotkb:Q16543 intact:EBI-2850249|uniprotkb:Q9NWW4|uniprotkb:Q9BUL7|uniprotkb:Q06DX1|uniprotkb:Q06DW8|uniprotkb:Q06DX0|intact:EBI-28984741|ensembl:ENSP00000218056|ensembl:ENSP00000365919 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:wdr13_human(display_long)|uniprotkb:WDR13(gene name)|psi-mi:WDR13(display_short) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484605|imex:IM-22301-1754 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011542249.1|refseq:NP_001159898.1|refseq:NP_001334146.1|refseq:NP_001334148.1|refseq:NP_060353.2|ensembl:ENSP00000218056|ensembl:ENSP00000365919|ensembl:ENSG00000101940(gene)|ensembl:ENST00000218056(transcript)|ensembl:ENST00000376729(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:1904691"(negative regulation of type B pancreatic cell proliferation)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|uniprotkb:Q9H1Z4(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3KW3X29IVXHwlFEfDj1j1MAekRQ9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:D4C199785C7A4D09|rigid:quOUSMYNAxIQ5TiHWqG1izAVagE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9H808 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-3921684|uniprotkb:J3KMZ1|ensembl:ENSP00000246112 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:tle6_human(display_long)|uniprotkb:TLE6(gene name)|psi-mi:TLE6(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484685|imex:IM-22301-1759 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:XP_011526602.1|refseq:XP_011526603.1|refseq:NP_001137458.1|refseq:NP_079036.1|ensembl:ENSG00000104953(gene)|ensembl:ENST00000246112(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0106333"(subcortical maternal complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR009146(Groucho/transducin-like enhancer)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|refseq:XP_005259702.1|uniprotkb:Q9H808(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:176XHlcN9+N9RFwmiNoM0JS56TY9606 intact-crc:8C44F43AE00F9402|rigid:YCm8yEOrBGvMmM4xkjAY2Jgv87E false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9H5Y7 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9479007|uniprotkb:A8K9S8|uniprotkb:Q495Q0|uniprotkb:Q9NT60|uniprotkb:Q9HAA8|uniprotkb:Q6AW93|ensembl:ENSP00000495507|ensembl:ENSP00000496428 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:slik6_human(display_long)|uniprotkb:SLITRK6(gene name)|psi-mi:SLITRK6(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484669|imex:IM-22301-1758 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_115605.2|ensembl:ENSG00000184564(gene)|ensembl:ENST00000643778(transcript)|ensembl:ENST00000647374(transcript)|go:"GO:0001964"(startle response)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0007601"(visual perception)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009986"(cell surface)|go:"GO:0021562"(vestibulocochlear nerve development)|go:"GO:0031223"(auditory behavior)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060007"(linear vestibuloocular reflex)|go:"GO:0060384"(innervation)|go:"GO:0090102"(cochlea development)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR043326|reactome:R-HSA-388844|uniprotkb:Q9H5Y7(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:mbNZLeR/dYvBZJnjdq6Gdspp/749606 intact-crc:39F61218C5D7FC1E|rigid:hgC9l9GTb2y112yKB2oZB7GbMyM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9HBG6 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484732|imex:IM-22301-1762 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1|uniprotkb:Q9HBG6(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 intact-crc:FD0DE8244F53C9AB|rigid:/+1AaCcjvXJaTb716SqXlnWDvJM false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HBG6 uniprotkb:B4DYC6 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 intact:EBI-9357028 psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484716|imex:IM-22301-1761 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1|uniprotkb:Q9HBG6(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:16B823353672EA0A|rigid:oYWi81fqR1h49sdvmF9tVfzyzqg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9H967 intact:EBI-9357028 intact:EBI-1176089|uniprotkb:A0MNP5|uniprotkb:Q05CI4|ensembl:ENSP00000263795 psi-mi:b4dyc6_human(display_long) psi-mi:wdr76_human(display_long)|uniprotkb:WDR76(gene name)|psi-mi:WDR76(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484700|imex:IM-22301-1760 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001161413.1|refseq:NP_079184.2|ensembl:ENSG00000092470(gene)|ensembl:ENST00000263795(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0090734"(site of DNA damage)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR033052|interpro:IPR036322|refseq:XP_005254737.1|uniprotkb:Q9H967(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:w8vcsTpVbxVcThbcxsCbv4kbsqo9606 intact-crc:F1297E09B846138A|rigid:QA8qkzMcgrnRjPL0wZSP67JtNNo false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NR64 uniprotkb:Q8WVJ2 intact:EBI-6426228|ensembl:ENSP00000367075|uniprotkb:Q9P238|uniprotkb:Q9NR65|uniprotkb:Q9H4X4|uniprotkb:Q5VZ64|uniprotkb:A8K5X0 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:klhl1_human(display_long)|uniprotkb:KLHL1(gene name)|psi-mi:KLHL1(display_short)|uniprotkb:KIAA1490(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484762|imex:IM-22301-1764 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043025"(neuronal cell body)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|go:"GO:0030425"(dendrite)|ensembl:ENSG00000150361(gene)|ensembl:ENST00000377844(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007628"(adult walking behavior)|go:"GO:0016358"(dendrite development)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030036"(actin cytoskeleton organization)|refseq:NP_001273654.1|refseq:NP_065917.1|uniprotkb:Q9NR64(identity)|ddbj/embl/genbank:BC022460|entrezgene/locuslink:57626(identity)|human orfeome collection:1288(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Gp9F8Tdw0CwwDBqqhxae+RIDNfc9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:DD9BADCA4CBB61A8|rigid:S12bdjUNZa+DsiPPzLqtj6k9Nlc false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9HBG6 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484747|imex:IM-22301-1763 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1|uniprotkb:Q9HBG6(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 intact-crc:D6EA2C7394974046|rigid:4TNYBs5wxDEhQ5s6xrpIsJhLDRE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NRG9 uniprotkb:Q9Y266 intact:EBI-3912901|uniprotkb:Q9UG19|uniprotkb:Q9NWI6|uniprotkb:Q5JB47|ensembl:ENSP00000209873 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:aaas_human(display_long)|uniprotkb:AAAS(gene name)|psi-mi:AAAS(display_short)|uniprotkb:ADRACALA(gene name synonym)|uniprotkb:Adracalin(gene name synonym)|uniprotkb:GL003(orf name) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484795|imex:IM-22301-1766 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166937.1|refseq:NP_056480.1|ensembl:ENSG00000094914(gene)|ensembl:ENST00000209873(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007612"(learning)|go:"GO:0009566"(fertilization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-8980692|reactome:R-HSA-9609690|reactome:R-HSA-9610379|uniprotkb:Q9NRG9(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fdOcZ59NldwaQJ6nusjn8GAhszo9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:EE98BEB2B2F7CCF4|rigid:KIUSmY9tz/1jNPUMCynk+bZ2Scs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NRG9 uniprotkb:Q8IVD9 intact:EBI-3912901|uniprotkb:Q9UG19|uniprotkb:Q9NWI6|uniprotkb:Q5JB47|ensembl:ENSP00000209873 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:aaas_human(display_long)|uniprotkb:AAAS(gene name)|psi-mi:AAAS(display_short)|uniprotkb:ADRACALA(gene name synonym)|uniprotkb:Adracalin(gene name synonym)|uniprotkb:GL003(orf name) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484780|imex:IM-22301-1765 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166937.1|refseq:NP_056480.1|ensembl:ENSG00000094914(gene)|ensembl:ENST00000209873(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007612"(learning)|go:"GO:0009566"(fertilization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051028"(mRNA transport)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-8980692|reactome:R-HSA-9609690|reactome:R-HSA-9610379|uniprotkb:Q9NRG9(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:fdOcZ59NldwaQJ6nusjn8GAhszo9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:568E6276C17A3684|rigid:tuQOBSRtaN5qlH7hWFIAllVZ0Ok false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9NW82 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2515581|ensembl:ENSP00000265107|uniprotkb:Q9H053 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:wdr70_human(display_long)|uniprotkb:WDR70(gene name)|psi-mi:WDR70(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484825|imex:IM-22301-1768 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) ensembl:ENSG00000082068(gene)|ensembl:ENST00000265107(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0019899"(enzyme binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:1903775"(regulation of DNA double-strand break processing)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:6ZYM|rcsb pdb:7A5P|interpro:IPR001680(WD40 repeat)|refseq:NP_060504.1|uniprotkb:Q9NW82(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:hG9Nbynx50TVtGujhzTLx3dBTKM9606 intact-crc:BA74C52FFBD8B239|rigid:nIEkco1FdDC9eKjHHYIchIjv1/M false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9NVR0 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2691832|ensembl:ENSP00000314608 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh11_human(display_long)|uniprotkb:KLHL11(gene name)|psi-mi:KLHL11(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484810|imex:IM-22301-1767 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_060613.1|ensembl:ENSG00000178502(gene)|ensembl:ENST00000319121(transcript)|go:"GO:0005829"(cytosol)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|rcsb pdb:3I3N|rcsb pdb:4AP2|rcsb pdb:4APF|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9NVR0(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:ISfHscVtbG2cky5Fjw2NUisDJso9606 intact-crc:FC0935D3DB4EAD32|rigid:8cp1Bfg/Gyefn2++KpWMDYyJf5k false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9UBU9 intact:EBI-9357028 intact:EBI-398874|uniprotkb:Q99799|uniprotkb:Q9UQL2|uniprotkb:B4E269|ensembl:ENSP00000436679|ensembl:ENSP00000294172 psi-mi:b4dyc6_human(display_long) psi-mi:nxf1_human(display_long)|uniprotkb:NXF1(gene name)|psi-mi:NXF1(display_short)|uniprotkb:TAP(gene name synonym)|uniprotkb:Tip-associating protein(gene name synonym)|uniprotkb:Tip-associated protein(gene name synonym)|uniprotkb:mRNA export factor TAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484856|imex:IM-22301-1770 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001074960.1|refseq:NP_006353.2|ensembl:ENSP00000294172|ensembl:ENST00000531709|ensembl:ENSP00000453885|ensembl:ENSP00000436679|dip:DIP-31789N|ensembl:ENST00000294172(transcript)|ensembl:ENST00000532297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0015031"(protein transport)|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042405"(nuclear inclusion body)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR005637(TAP, C-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015245(Tap, RNA-binding)|interpro:IPR018222|interpro:IPR030217|interpro:IPR032675|interpro:IPR032710|interpro:IPR035979|mint:Q9UBU9|rcsb pdb:1FO1|rcsb pdb:1FT8|rcsb pdb:1GO5|rcsb pdb:1JKG|rcsb pdb:1JN5|rcsb pdb:1KOH|rcsb pdb:1KOO|rcsb pdb:1OAI|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:3RW6|rcsb pdb:3RW7|rcsb pdb:4WYK|rcsb pdb:6E5U|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|ensembl:ENSG00000162231(gene)|uniprotkb:Q9UBU9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:a983QBMgsm07FV/IcYsO37Sk0hU9606 intact-crc:1EA314C40BC3937F|rigid:Ic7ZKifcZYQY3T009KkI9C2HyHg false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9P2S5 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-1054904|uniprotkb:Q5T0D6|uniprotkb:Q9BUH7|uniprotkb:Q9NTK7|uniprotkb:Q9NX56|ensembl:ENSP00000270708 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:wrp73_human(display_long)|uniprotkb:WRAP73(gene name)|psi-mi:WRAP73(display_short)|uniprotkb:WDR8(gene name synonym)|uniprotkb:WD repeat-containing protein 8(gene name synonym)|uniprotkb:WD repeat-containing protein antisense to TP73 gene(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484841|imex:IM-22301-1769 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_060288.3|ensembl:ENSG00000116213(gene)|ensembl:ENST00000270708(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0030030"(cell projection organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1902440"(protein localization to mitotic spindle pole body)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1990811"(MWP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:Q9P2S5|uniprotkb:Q9P2S5(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:H5LC0HbUA2MqmXzFg7y256KDg2U9606 intact-crc:788B7A4377ED7B68|rigid:KF3L70LCxuKyaLFOlH6cdeULHlE false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9UFC0 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-2560091|uniprotkb:B2R9G2|uniprotkb:Q96GJ2|uniprotkb:Q8WV43|uniprotkb:Q8N0T9|uniprotkb:A8K4K2|ensembl:ENSP00000292616 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:lrwd1_human(display_long)|uniprotkb:LRWD1(gene name)|psi-mi:LRWD1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:Origin recognition complex-associated protein(gene name synonym)|uniprotkb:Centromere protein 33(gene name synonym)|uniprotkb:CENP-33(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484903|imex:IM-22301-1773 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_690852.1|refseq:NP_001304650.1|ensembl:ENSG00000161036(gene)|ensembl:ENST00000292616(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006325"(chromatin organization)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001680(WD40 repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR025875|interpro:IPR032675|interpro:IPR036322|uniprotkb:Q9UFC0(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:kTtJakebuHc0bpsFff8iMMfEBqA9606 intact-crc:194CEE5FF82C1AFD|rigid:psUAQ8PPsPLVBdGx+iv8mXNeVQA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UFC0 uniprotkb:B4DYC6 intact:EBI-2560091|uniprotkb:B2R9G2|uniprotkb:Q96GJ2|uniprotkb:Q8WV43|uniprotkb:Q8N0T9|uniprotkb:A8K4K2|ensembl:ENSP00000292616 intact:EBI-9357028 psi-mi:lrwd1_human(display_long)|uniprotkb:LRWD1(gene name)|psi-mi:LRWD1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:Origin recognition complex-associated protein(gene name synonym)|uniprotkb:Centromere protein 33(gene name synonym)|uniprotkb:CENP-33(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484887|imex:IM-22301-1772 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_690852.1|refseq:NP_001304650.1|ensembl:ENSG00000161036(gene)|ensembl:ENST00000292616(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006325"(chromatin organization)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001680(WD40 repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR025875|interpro:IPR032675|interpro:IPR036322|uniprotkb:Q9UFC0(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:kTtJakebuHc0bpsFff8iMMfEBqA9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:8E91880188C01F95|rigid:TSGQKnT/hW5C4H6qorScaimrZYQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96RS6 uniprotkb:Q9UBU9 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-398874|uniprotkb:Q99799|uniprotkb:Q9UQL2|uniprotkb:B4E269|ensembl:ENSP00000436679|ensembl:ENSP00000294172 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:nxf1_human(display_long)|uniprotkb:NXF1(gene name)|psi-mi:NXF1(display_short)|uniprotkb:TAP(gene name synonym)|uniprotkb:Tip-associating protein(gene name synonym)|uniprotkb:Tip-associated protein(gene name synonym)|uniprotkb:mRNA export factor TAP(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484872|imex:IM-22301-1771 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001074960.1|refseq:NP_006353.2|ensembl:ENSP00000294172|ensembl:ENST00000531709|ensembl:ENSP00000453885|ensembl:ENSP00000436679|dip:DIP-31789N|ensembl:ENST00000294172(transcript)|ensembl:ENST00000532297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0015031"(protein transport)|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042405"(nuclear inclusion body)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR005637(TAP, C-terminal)|interpro:IPR009060(UBA-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR015245(Tap, RNA-binding)|interpro:IPR018222|interpro:IPR030217|interpro:IPR032675|interpro:IPR032710|interpro:IPR035979|mint:Q9UBU9|rcsb pdb:1FO1|rcsb pdb:1FT8|rcsb pdb:1GO5|rcsb pdb:1JKG|rcsb pdb:1JN5|rcsb pdb:1KOH|rcsb pdb:1KOO|rcsb pdb:1OAI|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:3RW6|rcsb pdb:3RW7|rcsb pdb:4WYK|rcsb pdb:6E5U|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|ensembl:ENSG00000162231(gene)|uniprotkb:Q9UBU9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:a983QBMgsm07FV/IcYsO37Sk0hU9606 intact-crc:039052D23B27456D|rigid:qCy9TuFAuY7V2lojHPSN0Oi9C0w false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UII4 uniprotkb:Q8WVJ2 intact:EBI-2339540|uniprotkb:B2RTQ1|uniprotkb:Q69G20|intact:EBI-28975860|ensembl:ENSP00000264350 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:herc5_human(display_long)|uniprotkb:HERC5(gene name)|psi-mi:HERC5(display_short)|uniprotkb:CEB1(gene name synonym)|uniprotkb:CEBP1(gene name synonym)|uniprotkb:HECT domain and RCC1-like domain-containing protein 5(gene name synonym)|uniprotkb:Cyclin-E-binding protein 1(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484933|imex:IM-22301-1775 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000264350|refseq:NP_057407.2|dip:DIP-44200N|ensembl:ENSG00000138646(gene)|ensembl:ENST00000264350(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000569(HECT)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR035983|mint:Q9UII4|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-936440|reactome:R-HSA-983168|uniprotkb:Q9UII4(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:IGuce5qcdMB8PC5u6b6A57FODKY9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:5881F1F6A5894128|rigid:P+QM5iEjf21DWcLppFrzI/gkfYQ false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UGK8 uniprotkb:Q8WVJ2 intact:EBI-465368|uniprotkb:Q9UGK9|ensembl:ENSP00000265965 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:srgef_human(display_long)|uniprotkb:SERGEF(gene name)|psi-mi:SERGEF(display_short)|uniprotkb:DELGEF(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor-related protein(gene name synonym)|uniprotkb:Deafness locus-associated putative guanine nucleotide exchange factor(gene name synonym)|uniprotkb:GNEFR(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484918|imex:IM-22301-1774 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000265965(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|mint:Q9UGK8|ensembl:ENSG00000129158(gene)|refseq:NP_036271.1|uniprotkb:Q9UGK8(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3+CMCq/X3/IP+yj7Tp3p+tOvKto9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:8715352029D3F672|rigid:Wrv95MvMjRXQson2c5J9LvKonSE false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8WVJ2 uniprotkb:Q9UJT9 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 intact:EBI-914660|uniprotkb:D6RDY7|uniprotkb:O94926|uniprotkb:B9EGF1|ensembl:ENSP00000423630 psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:fbxl7_human(display_long)|uniprotkb:FBXL7(gene name)|psi-mi:FBXL7(display_short)|uniprotkb:FBL6(gene name synonym)|uniprotkb:FBL7(gene name synonym)|uniprotkb:KIAA0840(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 7(gene name synonym)|uniprotkb:F-box protein FBL6/FBL7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484966|imex:IM-22301-1777 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) refseq:NP_036436.1|refseq:XP_011512300.1|refseq:NP_001265246.1|ensembl:ENSG00000183580(gene)|ensembl:ENST00000504595(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8854050|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UJT9(identity) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 rogid:SQlLA1fvKZIl4c0//ultDJ0FNxQ9606 intact-crc:2A70893834C3FA3C|rigid:yKm139QknLotDkGEff5tLnq6pCc false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UJT9 uniprotkb:B4DYC6 intact:EBI-914660|uniprotkb:D6RDY7|uniprotkb:O94926|uniprotkb:B9EGF1|ensembl:ENSP00000423630 intact:EBI-9357028 psi-mi:fbxl7_human(display_long)|uniprotkb:FBXL7(gene name)|psi-mi:FBXL7(display_short)|uniprotkb:FBL6(gene name synonym)|uniprotkb:FBL7(gene name synonym)|uniprotkb:KIAA0840(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 7(gene name synonym)|uniprotkb:F-box protein FBL6/FBL7(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484950|imex:IM-22301-1776 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036436.1|refseq:XP_011512300.1|refseq:NP_001265246.1|ensembl:ENSG00000183580(gene)|ensembl:ENST00000504595(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8854050|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UJT9(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:SQlLA1fvKZIl4c0//ultDJ0FNxQ9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:4CE052F04181C79B|rigid:kriNfHN0RqorXRImM4+K/HSAST8 false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9UMS4 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-395746|ensembl:ENSP00000227524 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:prp19_human(display_long)|uniprotkb:PRPF19(gene name)|psi-mi:PRPF19(display_short)|uniprotkb:PRP19/PSO4 homolog(gene name synonym)|uniprotkb:Nuclear matrix protein 200(gene name synonym)|uniprotkb:Senescence evasion factor(gene name synonym)|uniprotkb:NMP200(gene name synonym)|uniprotkb:PRP19(gene name synonym)|uniprotkb:SNEV(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PRP19(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485011|imex:IM-22301-1780 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) ensembl:ENSG00000110107(gene)|ensembl:ENST00000227524(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000349"(generation of catalytic spliceosome for first transesterification step)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005819"(spindle)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|refseq:NP_055317.1|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001680(WD40 repeat)|interpro:IPR003613(U box)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013915(Pre-mRNA-splicing factor 19)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR038959|mint:Q9UMS4|rcsb pdb:4LG8|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:7A5P|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-72163|dip:DIP-32978N|uniprotkb:Q9UMS4(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:5TseaFcCOVVWjJeMF/H7k29nd3c9606 intact-crc:FD8CA1B0287431A9|rigid:8PMrLnEi112P5b8mJ8T8bqQk20c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UL63 uniprotkb:Q8WVJ2 intact:EBI-1048053|uniprotkb:A4D1M8|uniprotkb:A6NG43|uniprotkb:Q9NSK4|uniprotkb:Q9NUS8|ensembl:ENSP00000323527 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:mkln1_human(display_long)|uniprotkb:MKLN1(gene name)|psi-mi:MKLN1(display_short) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484996|imex:IM-22301-1779 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138826.1|refseq:NP_037387.2|ensembl:ENSG00000128585(gene)|ensembl:ENST00000352689(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001726"(ruffle)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0098794"(postsynapse)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010565(Muskelin, N-terminal)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015915(Kelch-type beta propeller)|mint:Q9UL63|refseq:NP_001308245.1|uniprotkb:Q9UL63(identity) refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N|uniprotkb:Q8WVJ2(identity) psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:7yT0576+rLpdpgT/cqXPEuf80/g9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:CD8A6B3EA37AC6B8|rigid:2N2WUawj9CGC21Iw8CdXUv65r4o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y266 uniprotkb:Q9UJT9 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-914660|uniprotkb:D6RDY7|uniprotkb:O94926|uniprotkb:B9EGF1|ensembl:ENSP00000423630 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:fbxl7_human(display_long)|uniprotkb:FBXL7(gene name)|psi-mi:FBXL7(display_short)|uniprotkb:FBL6(gene name synonym)|uniprotkb:FBL7(gene name synonym)|uniprotkb:KIAA0840(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 7(gene name synonym)|uniprotkb:F-box protein FBL6/FBL7(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9484981|imex:IM-22301-1778 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) refseq:NP_036436.1|refseq:XP_011512300.1|refseq:NP_001265246.1|ensembl:ENSG00000183580(gene)|ensembl:ENST00000504595(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-8854050|reactome:R-HSA-8951664|reactome:R-HSA-983168|uniprotkb:Q9UJT9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:SQlLA1fvKZIl4c0//ultDJ0FNxQ9606 intact-crc:2D217D17C4AE0120|rigid:RA9/cqxFdasU/KYkvpcvOkIDFb8 false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ03 uniprotkb:Q9Y266 intact:EBI-723376|uniprotkb:O94767|uniprotkb:Q8TAN1|uniprotkb:A8K0W3|ensembl:ENSP00000261861 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:cor2b_human(display_long)|uniprotkb:Coronin-like protein C(gene name synonym)|uniprotkb:Protein FC96(gene name synonym)|uniprotkb:CORO2B(gene name)|psi-mi:CORO2B(display_short)|uniprotkb:KIAA0925(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485042|imex:IM-22301-1782 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001177385.1|refseq:NP_001177386.1|refseq:NP_006082.3|refseq:NP_001310943.1|refseq:NP_001310944.1|ensembl:ENSG00000103647(gene)|ensembl:ENST00000261861(transcript)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:1904950"(negative regulation of establishment of protein localization)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1990147"(talin binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027339|interpro:IPR036322|uniprotkb:Q9UQ03(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:7KUlG6rFuomPMKz+8jqEzXKFsN89606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:19683EA20471D81B|rigid:0vefSjyGvEnZfhPmsm4qSJnoxNs false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B4DYC6 uniprotkb:Q9UQ03 intact:EBI-9357028 intact:EBI-723376|uniprotkb:O94767|uniprotkb:Q8TAN1|uniprotkb:A8K0W3|ensembl:ENSP00000261861 psi-mi:b4dyc6_human(display_long) psi-mi:cor2b_human(display_long)|uniprotkb:Coronin-like protein C(gene name synonym)|uniprotkb:Protein FC96(gene name synonym)|uniprotkb:CORO2B(gene name)|psi-mi:CORO2B(display_short)|uniprotkb:KIAA0925(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485026|imex:IM-22301-1781 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) refseq:NP_001177385.1|refseq:NP_001177386.1|refseq:NP_006082.3|refseq:NP_001310943.1|refseq:NP_001310944.1|ensembl:ENSG00000103647(gene)|ensembl:ENST00000261861(transcript)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:1904950"(negative regulation of establishment of protein localization)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1990147"(talin binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027339|interpro:IPR036322|uniprotkb:Q9UQ03(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 rogid:7KUlG6rFuomPMKz+8jqEzXKFsN89606 intact-crc:63EA6AE118A01AB9|rigid:Yhdmnu5XOxsNAm+sTA/IQrpz2Mk false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQ13 uniprotkb:B4DYC6 intact:EBI-993879|uniprotkb:O76063|uniprotkb:A8K9W8|uniprotkb:B3KR23|uniprotkb:Q5VZS8|uniprotkb:Q5VZS9|ensembl:ENSP00000358464 intact:EBI-9357028 psi-mi:shoc2_human(display_long)|uniprotkb:Protein soc-2 homolog(gene name synonym)|uniprotkb:SHOC2(gene name)|psi-mi:SHOC2(display_short)|uniprotkb:KIAA0862(gene name synonym)|uniprotkb:Protein sur-8 homolog(gene name synonym) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485073|imex:IM-22301-1784 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031399.2|refseq:NP_001311265.1|refseq:NP_001311266.1|refseq:NP_001255968.1|refseq:XP_016872191.1|refseq:XP_016872192.1|refseq:XP_016872193.1|ensembl:ENSG00000108061(gene)|ensembl:ENST00000369452(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027036|interpro:IPR032675|mint:Q9UQ13|reactome:R-HSA-5673000|reactome:R-HSA-9660537|uniprotkb:Q9UQ13(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:0RkCETF3NG59IZjnJevXVYkzBJU9606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:522AADFB7E69245C|rigid:ggI0aW9lTjQ7bw7hIzWQGRsALzg false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16543 uniprotkb:Q9UQ07 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1388900|uniprotkb:B2R6Z4|uniprotkb:B7Z7P6|uniprotkb:E7ER76|uniprotkb:E7ERR8|uniprotkb:Q92790|uniprotkb:Q93067|ensembl:ENSP00000355304 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:mok_human(display_long)|uniprotkb:RAGE1(gene name synonym)|uniprotkb:MOK protein kinase(gene name synonym)|uniprotkb:Renal tumor antigen 1(gene name synonym)|uniprotkb:MOK(gene name)|psi-mi:MOK(display_short)|uniprotkb:RAGE(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485057|imex:IM-22301-1783 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity) refseq:NP_055041.1|refseq:NP_001317163.1|refseq:NP_001258940.1|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000080823(gene)|ensembl:ENST00000361847(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|uniprotkb:Q9UQ07(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:5aY9xKiNzvz9SCiixMmocAwdnHU9606 intact-crc:315D081CE8956500|rigid:3v9qAS4p9/H+7OXhyFoytt2jWyI false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9Y2U9 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-715326|uniprotkb:Q86TY9|uniprotkb:Q6IAF0|uniprotkb:B3KPF9|ensembl:ENSP00000298307 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:kldc2_human(display_long)|uniprotkb:Hepatocellular carcinoma-associated antigen 33(gene name synonym)|uniprotkb:Host cell factor homolog LCP(gene name synonym)|uniprotkb:Host cell factor-like protein 1(gene name synonym)|uniprotkb:KLHDC2(gene name)|psi-mi:KLHDC2(display_short)|uniprotkb:HCA33(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485105|imex:IM-22301-1786 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_055130.1|ensembl:ENSG00000165516(gene)|ensembl:ENST00000298307(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR015915(Kelch-type beta propeller)|mint:Q9Y2U9|rcsb pdb:6DO3|rcsb pdb:6DO4|rcsb pdb:6DO5|go:"GO:0016604"(nuclear body)|uniprotkb:Q9Y2U9(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:YWJMGSX2MqvROFP492LhtVCjgrw9606 intact-crc:2056803C19837AFB|rigid:QCfj8HykCwtm55kWMsR69af5MJA false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y2L9 uniprotkb:B4DYC6 intact:EBI-2797324|uniprotkb:Q7Z5F7|uniprotkb:Q7Z5F6|uniprotkb:Q5TBU9|uniprotkb:Q2KHR1|uniprotkb:B7ZLL5|uniprotkb:F8W6F0|uniprotkb:Q17R43|ensembl:ENSP00000374448 intact:EBI-9357028 psi-mi:lrch1_human(display_long)|uniprotkb:CHDC1(gene name synonym)|uniprotkb:KIAA1016(gene name synonym)|uniprotkb:Calponin homology domain-containing protein 1(gene name synonym)|uniprotkb:Neuronal protein 81(gene name synonym)|uniprotkb:LRCH1(gene name)|psi-mi:LRCH1(display_short) psi-mi:b4dyc6_human(display_long) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485089|imex:IM-22301-1785 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157685.1|refseq:NP_055931.1|refseq:NP_001157683.1|ensembl:ENSG00000136141(gene)|ensembl:ENST00000389798(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036872|uniprotkb:Q9Y2L9(identity) interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|refseq:NP_001307760.1|interpro:IPR044563|go:"GO:0051087"(chaperone binding)|uniprotkb:F5H5A9(identity)|entrezgene/locuslink:10910(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/06/10 rogid:3oNqV4dI/4ZHz1sUSsc8nmg0j049606 rogid:IhR6XQTXzE38Vnu426H5aFedaHA9606 intact-crc:C9BA4AE815F8FCD8|rigid:BgPIwnpOlpS4lT0SHvfRRJQhfkw false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y5Z7 uniprotkb:Q9Y266 intact:EBI-592728|uniprotkb:B2R8Q5|uniprotkb:C0H5X3|ensembl:ENSP00000229330 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:hcfc2_human(display_long)|uniprotkb:C2 factor(gene name synonym)|uniprotkb:HCFC2(gene name)|psi-mi:HCFC2(display_short) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485135|imex:IM-22301-1788 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037452.1|ensembl:ENSG00000111727(gene)|ensembl:ENST00000229330(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016032"(viral process)|go:"GO:0016604"(nuclear body)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037932|interpro:IPR043536|mint:Q9Y5Z7|uniprotkb:Q9Y5Z7(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ytE7Aid9JO9RWsRpJPpBbylLRXo9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:86DDE291EAE0CDC3|rigid:/9Op7yOiA+u4DheCjywYQIz2L5o false flag tag:c-c("MI:0518") renilla luciferase protein tag:c-c("MI:0896") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IVD9 uniprotkb:Q9Y5Z7 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-592728|uniprotkb:B2R8Q5|uniprotkb:C0H5X3|ensembl:ENSP00000229330 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:hcfc2_human(display_long)|uniprotkb:C2 factor(gene name synonym)|uniprotkb:HCFC2(gene name)|psi-mi:HCFC2(display_short) psi-mi:"MI:0729"(luminescence based mammalian interactome mapping) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9485120|imex:IM-22301-1787 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity) refseq:NP_037452.1|ensembl:ENSG00000111727(gene)|ensembl:ENST00000229330(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016032"(viral process)|go:"GO:0016604"(nuclear body)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0071339"(MLL1 complex)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037932|interpro:IPR043536|mint:Q9Y5Z7|uniprotkb:Q9Y5Z7(identity) psi-mi:"MI:0469"(intact) - - figure legend:7a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:ytE7Aid9JO9RWsRpJPpBbylLRXo9606 intact-crc:79567E35D333614B|rigid:i58QwyaRz8whAf9CNRr1pIexm9c false renilla luciferase protein tag:c-c("MI:0896") flag tag:c-c("MI:0518") - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BTE6 uniprotkb:P04792 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|genbank_protein_gi:4504517(identity)|ddbj/embl/genbank:BC012292(identity)|entrezgene/locuslink:3315(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE6 uniprotkb:P63172 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-1176455|uniprotkb:Q15763|ensembl:ENSP00000356056|uniprotkb:Q5VTU4 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:dylt1_human(display_long)|uniprotkb:T-complex testis-specific protein 1 homolog(gene name synonym)|uniprotkb:Protein CW-1(gene name synonym)|uniprotkb:DYNLT1(gene name)|psi-mi:DYNLT1(display_short)|uniprotkb:TCTEL1(gene name synonym)|uniprotkb:TCTEX1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_006510.1|ensembl:ENSG00000146425(gene)|ensembl:ENST00000367089(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005576"(extracellular region)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030027"(lamellipodium)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043657"(host cell)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061564"(axon development)|go:"GO:0075521"(microtubule-dependent intracellular transport of viral material towards nucleus)|go:"GO:0099503"(secretory vesicle)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|rcsb pdb:5JPW|reactome:R-HSA-6798695|go:"GO:0005881"(cytoplasmic microtubule)|dip:DIP-35251N|uniprotkb:P63172(identity)|genbank_protein_gi:5730085(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:RKVyHgf4iNjcY6GfLdIukFOFE+s9606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE6 uniprotkb:Q71U36 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE6 uniprotkb:O14654 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-356594|ensembl:ENSP00000505547 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE6 uniprotkb:Q9ULT8 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-310559|uniprotkb:Q6P445|uniprotkb:Q86VJ1|uniprotkb:Q96F34|uniprotkb:Q9UFZ7|uniprotkb:D3DS86|ensembl:ENSP00000382269|ensembl:ENSP00000450697 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:hecd1_human(display_long)|uniprotkb:HECTD1(gene name)|psi-mi:HECTD1(display_short)|uniprotkb:KIAA1131(gene name synonym)|uniprotkb:HECT domain-containing protein 1(gene name synonym)|uniprotkb:E3 ligase for inhibin receptor(gene name synonym)|uniprotkb:EULIR(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECTD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) ensembl:ENSG00000092148(gene)|ensembl:ENST00000399332(transcript)|ensembl:ENST00000553700(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR000569(HECT)|interpro:IPR002110(Ankyrin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010606(Mib-herc2)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020683|interpro:IPR035983|interpro:IPR036770|interpro:IPR037252|interpro:IPR041200|mint:Q9ULT8|rcsb pdb:2DK3|rcsb pdb:3DKM|reactome:R-HSA-983168|rcsb pdb:2LC3|refseq:XP_005267559.2|ensembl:ENSP00000382269|ensembl:ENSP00000450697|refseq:NP_056197.3|dip:DIP-31669N|uniprotkb:Q9ULT8(identity)|genbank_protein_gi:118498337(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:/l60ZSm+P4Vlc8B79wS7+T1Zvzk9606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE6 uniprotkb:P50454 intact:EBI-2796199|uniprotkb:B4DI73|ensembl:ENSP00000400870 intact:EBI-350723|uniprotkb:P29043|uniprotkb:Q5XPB4|uniprotkb:Q6NSJ6|uniprotkb:Q8IY96|uniprotkb:Q9NP88|uniprotkb:B3KVJ3|ensembl:ENSP00000350894|ensembl:ENSP00000434412|ensembl:ENSP00000434657 psi-mi:aasd1_human(display_long)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)|uniprotkb:AARSD1(gene name)|psi-mi:AARSD1(display_short) psi-mi:serph_human(display_long)|uniprotkb:SERPINH1(gene name)|psi-mi:SERPINH1(display_short)|uniprotkb:CBP2(gene name synonym)|uniprotkb:Collagen-binding protein(gene name synonym)|uniprotkb:47 kDa heat shock protein(gene name synonym)|uniprotkb:Rheumatoid arthritis-related antigen RA-A47(gene name synonym)|uniprotkb:Arsenic-transactivated protein 3(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 14 protein(gene name synonym)|uniprotkb:CBP1(gene name synonym)|uniprotkb:HSP47(gene name synonym)|uniprotkb:SERPINH2(gene name synonym)|uniprotkb:PIG14(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392829|imex:IM-22301-1563 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079543.1|refseq:NP_001129514.2|refseq:NP_001248363.1|ensembl:ENSG00000266967(gene)|ensembl:ENST00000427569(transcript)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|uniprotkb:Q9BTE6(identity)|entrezgene/locuslink:80755(identity)|ddbj/embl/genbank:BC004172(identity) refseq:NP_001193943.1|refseq:NP_001226.2|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033547|interpro:IPR033830|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P50454|reactome:R-HSA-1650814|ensembl:ENSG00000149257(gene)|ensembl:ENST00000358171(transcript)|ensembl:ENST00000524558(transcript)|ensembl:ENST00000533603(transcript)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|refseq:XP_011543629.1|uniprotkb:P50454(identity)|genbank_protein_gi:32454741(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:lTVaIdskWMt9ad808OfOSBPN9jg9606 rogid:cO3NR2hb0NyOs99Sq1aODePlDR09606 intact-crc:915907D750099E12|rigid:V8iUzlVb0v6mb1+s8iFbQP9Nn5c false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q86SX1 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-9392873 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q13451 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q02790 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:K9JA46 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-9392866 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q9UHD1 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q15785 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|uniprotkb:Q15785(identity)|genbank_protein_gi:21361356(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:P53041 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q9BW92 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1|uniprotkb:Q9BW92(identity)|genbank_protein_gi:20070344(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:Q08752 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95433 uniprotkb:P08238 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392870|imex:IM-22301-1564 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:076932E64221571F|rigid:QBXzSm2BWyr3NSq8RF6dCdXmXk0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:Q6IA69 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-748610|uniprotkb:Q86SN2|uniprotkb:Q9HA25|uniprotkb:Q9NVM8|uniprotkb:B3KUU4|ensembl:ENSP00000326424 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:nade_human(display_long)|uniprotkb:"NAD(+) synthase [glutamine-hydrolyzing]"(gene name synonym)|uniprotkb:"NAD(+) synthetase"(gene name synonym)|uniprotkb:NADSYN1(gene name)|psi-mi:NADSYN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) refseq:NP_060631.2|ensembl:ENSG00000172890(gene)|ensembl:ENST00000319023(transcript)|go:"GO:0003952"("NAD+ synthase (glutamine-hydrolyzing) activity")|go:"GO:0004359"(glutaminase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009435"(NAD biosynthetic process)|go:"GO:0034627"('de novo' NAD biosynthetic process)|interpro:IPR003010(Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase)|interpro:IPR003694(NAD+ synthase)|interpro:IPR014445("Glutamine-dependent NAD(+) synthetase, GAT region")|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR022310|interpro:IPR036526|rcsb pdb:6OFB|reactome:R-HSA-196807|uniprotkb:Q6IA69(identity)|genbank_protein_gi:41393551(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:6DRDevbKgH67/vzPqnrzCsQG47g9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:Q9NVR5 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-9392930|uniprotkb:Q86TR1|uniprotkb:Q969Z5|uniprotkb:Q86TY8|uniprotkb:C0JAP7|uniprotkb:B9WS54|ensembl:ENSP00000298292 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:ktu_human(display_long)|uniprotkb:DNAAF2(gene name)|psi-mi:DNAAF2(display_short)|uniprotkb:C14orf104(gene name synonym)|uniprotkb:Dynein assembly factor 2, axonemal(gene name synonym)|uniprotkb:KTU(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) refseq:NP_001077377.1|refseq:NP_060609.2|dip:DIP-59041N|ensembl:ENSG00000165506(gene)|ensembl:ENST00000298292(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0036159"(inner dynein arm assembly)|go:"GO:0060285"(cilium-dependent cell motility)|go:"GO:0061966"(establishment of left/right asymmetry)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR012981(Nop17p)|interpro:IPR034727|interpro:IPR041442|mint:Q9NVR5|uniprotkb:Q9NVR5(identity)|genbank_protein_gi:145580588(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:0ILCb1hggxCP1t8PFo2dClvPsRM9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:K9JA46 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-9392866 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:Q16543 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:Q15185 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:Q86SX1 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-9392873 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:O94966 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00170 uniprotkb:P08238 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392939|imex:IM-22301-1565 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:42CCFA6DA7923AC9|rigid:7nyOiXED8yLxKBc1YXW9CggdHoI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:O94822 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-1044684|uniprotkb:Q9H8M4|uniprotkb:Q9NUY5|uniprotkb:Q9P0E9|uniprotkb:A7E2D0|uniprotkb:B2RTS0|uniprotkb:C9J7U3|uniprotkb:Q05C47|uniprotkb:A6NL41|uniprotkb:J3KPL4|intact:EBI-11051127|ensembl:ENSP00000354977|ensembl:ENSP00000373846 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:ltn1_human(display_long)|uniprotkb:LTN1(gene name)|psi-mi:LTN1(display_short)|uniprotkb:ZNF294(gene name synonym)|uniprotkb:C21orf10(gene name synonym)|uniprotkb:C21orf98(gene name synonym)|uniprotkb:KIAA0714(gene name synonym)|uniprotkb:HSPC087(orf name)|uniprotkb:Zinc finger protein 294(gene name synonym)|uniprotkb:RNF160(gene name synonym)|uniprotkb:RING finger protein 160(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase listerin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) refseq:NP_056380.2|refseq:NP_001307695.1|ensembl:ENSG00000198862(gene)|ensembl:ENST00000361371(transcript)|ensembl:ENST00000389194(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1990112"(RQC complex)|go:"GO:1990116"(ribosome-associated ubiquitin-dependent protein catabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011016(Zinc finger, variant RING-type)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039795|interpro:IPR039804|rcsb pdb:3J92|reactome:R-HSA-983168|uniprotkb:O94822(identity)|genbank_protein_gi:231573214(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:ysR3JH2PPNrc1EwOpusyQoGrYFw9606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:Q15773 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:O75190 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:Q9UNE7 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:P25685 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99933 uniprotkb:Q9UDY4 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-356960|uniprotkb:Q13431|uniprotkb:B2R824|ensembl:ENSP00000359799 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:dnjb4_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:DNAJW(gene name synonym)|uniprotkb:HLJ1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1 homolog(gene name synonym)|uniprotkb:Human liver DnaJ-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9392988|imex:IM-22301-1566 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N|uniprotkb:Q99933(identity)|ddbj/embl/genbank:BC001936(identity)|entrezgene/locuslink:573(identity) refseq:NP_008965.2|refseq:NP_001304028.1|refseq:NP_001304029.1|refseq:NP_001304030.1|refseq:NP_001304031.1|refseq:NP_001304032.1|ensembl:ENSG00000162616(gene)|ensembl:ENST00000370763(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009408"(response to heat)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UDY4|uniprotkb:Q9UDY4(identity)|entrezgene/locuslink:11080(identity)|genbank_protein_gi:6631085(identity)|ddbj/embl/genbank:BC034721(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:gN0zBtJQiTN+YYSAtMk1mddNWLU9606 intact-crc:81F8B0C2DB67E637|rigid:vT4xx064WMVz4YiIealzuB+y8J4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:Q15773 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:P25685 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:Q9UNE7 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:O75190 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:Q15833 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-4401015|uniprotkb:Q9BU65|uniprotkb:B4E175|uniprotkb:E7EQD5|ensembl:ENSP00000221283 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:stxb2_human(display_long)|uniprotkb:STXBP2(gene name)|psi-mi:STXBP2(display_short)|uniprotkb:UNC18B(gene name synonym)|uniprotkb:Protein unc-18 homolog 2(gene name synonym)|uniprotkb:Protein unc-18 homolog B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) refseq:NP_001120868.1|refseq:NP_008880.2|refseq:NP_001258963.1|ensembl:ENSG00000076944(gene)|ensembl:ENST00000221283(transcript)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0042581"(specific granule)|go:"GO:0042582"(azurophil granule)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043312"(neutrophil degranulation)|go:"GO:0044194"(cytolytic granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070820"(tertiary granule)|go:"GO:0098793"(presynapse)|interpro:IPR001619(Sec1-like protein)|interpro:IPR027482|interpro:IPR036045|interpro:IPR043127|interpro:IPR043154|rcsb pdb:4CCA|reactome:R-HSA-114608|reactome:R-HSA-449836|uniprotkb:Q15833(identity)|ddbj/embl/genbank:BC002869(identity)|genbank_protein_gi:188528689(identity)|entrezgene/locuslink:6813(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:KNJQ1UD62S+WDYG1zWW0NOjVmLc9606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95816 uniprotkb:Q15750 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 intact:EBI-358643|uniprotkb:Q2PP09|intact:EBI-3959873|uniprotkb:Q8IZW2|ensembl:ENSP00000216160 psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:tab1_human(display_long)|uniprotkb:TAB1(gene name)|psi-mi:TAB1(display_short)|uniprotkb:MAP3K7IP1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393030|imex:IM-22301-1567 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) refseq:NP_006107.1|refseq:NP_705717.1|ensembl:ENSP00000216160|ensembl:ENST00000331454|ensembl:ENSP00000333049|go:"GO:0003279"(cardiac septum development)|rcsb pdb:7NTI|go:"GO:0003007"(heart morphogenesis)|ensembl:ENSG00000100324(gene)|ensembl:ENST00000216160(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q15750|rcsb pdb:2J4O|rcsb pdb:2POM|rcsb pdb:2POP|rcsb pdb:2YDS|rcsb pdb:2YIY|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4GS6|rcsb pdb:4KA3|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5DIY|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5V5N|rcsb pdb:5VVU|rcsb pdb:7NTH|reactome:R-HSA-168638|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27524N|uniprotkb:Q15750(identity)|genbank_protein_gi:41281798(identity)|ddbj/embl/genbank:BC050554(identity)|entrezgene/locuslink:10454(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 rogid:28+bzs6bpXJTun4XukxC/7oAYSs9606 intact-crc:4C35079683D4090F|rigid:GOr+6U9CJBM83E7ezwZ/qLryuQo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q9NR12 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-350517|uniprotkb:Q14250|uniprotkb:Q5XG82|uniprotkb:Q6NVZ5|uniprotkb:Q96C91|uniprotkb:Q9BXB8|uniprotkb:Q9BXB9|intact:EBI-2556830|ensembl:ENSP00000348099 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:pdli7_human(display_long)|uniprotkb:LIM mineralization protein(gene name synonym)|uniprotkb:Protein enigma(gene name synonym)|uniprotkb:PDLIM7(gene name)|psi-mi:PDLIM7(display_short)|uniprotkb:ENIGMA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_976227.1|refseq:NP_998801.1|refseq:NP_005442.2|ensembl:ENST00000355572|ensembl:ENSP00000347776|ensembl:ENSP00000348099|ensembl:ENST00000359895|ensembl:ENSP00000352964|ensembl:ENST00000393551|ensembl:ENSP00000377182|ensembl:ENST00000486828|ensembl:ENSP00000439157|ensembl:ENST00000493815|ensembl:ENSP00000431236|ensembl:ENSG00000196923(gene)|ensembl:ENST00000355841(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031941"(filamentous actin)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR036034|rcsb pdb:2Q3G|reactome:R-HSA-8853659|uniprotkb:Q9NR12(identity)|genbank_protein_gi:11496885(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:XBVF0Y1DFqIYbnt/e/rYqS/m4d09606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:P04792 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|genbank_protein_gi:4504517(identity)|ddbj/embl/genbank:BC012292(identity)|entrezgene/locuslink:3315(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q15773 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q9UNE7 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q969T9 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-727055|uniprotkb:B4DFG2|uniprotkb:O95638|ensembl:ENSP00000254806|ensembl:ENSP00000467579 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:wbp2_human(display_long)|uniprotkb:WBP2(gene name)|psi-mi:WBP2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_036610.2|refseq:NP_001317428.1|ensembl:ENSP00000254806|ensembl:ENST00000433525|ensembl:ENSP00000415251|ensembl:ENSP00000467579|ensembl:ENSG00000132471(gene)|ensembl:ENST00000254806(transcript)|ensembl:ENST00000591399(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|refseq:NP_001335099.1|dip:DIP-42509N|uniprotkb:Q969T9(identity)|ddbj/embl/genbank:BC007452(identity)|genbank_protein_gi:24430132(identity)|entrezgene/locuslink:23558(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:5BsaxPkt5Fr5KO/BfVZHbGSCz0w9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q9UJY1 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-739074|uniprotkb:Q6FIH3|uniprotkb:Q9UKS3|ensembl:ENSP00000281938|uniprotkb:B2R6A6 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:hspb8_human(display_long)|uniprotkb:HSPB8(gene name)|psi-mi:HSPB8(display_short)|uniprotkb:CRYAC(gene name synonym)|uniprotkb:E2IG1(gene name synonym)|uniprotkb:HSP22(gene name synonym)|uniprotkb:PP1629(orf name)|uniprotkb:Alpha-crystallin C chain(gene name synonym)|uniprotkb:Small stress protein-like protein HSP22(gene name synonym)|uniprotkb:E2-induced gene 1 protein(gene name synonym)|uniprotkb:Protein kinase H11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) ensembl:ENSG00000152137(gene)|ensembl:ENST00000281938(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0101031"(chaperone complex)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR042790|interpro:IPR043254|reactome:R-HSA-3371571|refseq:NP_055180.1|uniprotkb:Q9UJY1(identity)|genbank_protein_gi:7657146(identity)|entrezgene/locuslink:26353(identity)|ddbj/embl/genbank:BC002673(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:SXMGg+TeGqU6CI+A4ypCqCGNYks9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:O75190 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q86UU1 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-4289858|uniprotkb:Q4KMF8|uniprotkb:Q8TEQ2|uniprotkb:O75133|uniprotkb:B0YJ63|uniprotkb:B0YJ64|intact:EBI-28975144|ensembl:ENSP00000354498|ensembl:ENSP00000469820 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:phlb1_human(display_long)|uniprotkb:PHLDB1(gene name)|psi-mi:PHLDB1(display_short)|uniprotkb:KIAA0638(gene name synonym)|uniprotkb:LL5A(gene name synonym)|uniprotkb:Protein LL5-alpha(gene name synonym)|uniprotkb:DLNB07(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) ensembl:ENST00000356063|ensembl:ENSP00000348359|ensembl:ENSP00000354498|ensembl:ENST00000528594|ensembl:ENSP00000435520|ensembl:ENST00000530994|ensembl:ENSP00000431508|ensembl:ENSP00000469820|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037810|mint:Q86UU1|ensembl:ENSG00000019144(gene)|ensembl:ENST00000361417(transcript)|ensembl:ENST00000600882(transcript)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0045180"(basal cortex)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001138230.1|refseq:NP_001138231.1|refseq:NP_055972.1|uniprotkb:Q86UU1(identity)|genbank_protein_gi:221219024(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:Za4UuXVuMr4gzY2kr8EadOf5hWA9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95817 uniprotkb:Q4VCS5 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393075|imex:IM-22301-1568 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N|uniprotkb:Q4VCS5(identity)|genbank_protein_gi:166064029(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 intact-crc:7752F14BB60B0685|rigid:Lt8Li9DFOAUgqTDpzPxJ86zzAiY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:P25685 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:P54652 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|genbank_protein_gi:13676857(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:P34931 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-354912|uniprotkb:O75634|uniprotkb:Q2HXR3|uniprotkb:Q8NE72|uniprotkb:A6NNB0|uniprotkb:Q96QC9|uniprotkb:Q9UQM1|uniprotkb:B0UXW8|ensembl:ENSP00000364805|ensembl:ENSP00000372881|ensembl:ENSP00000396486|ensembl:ENSP00000408347 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:hs71l_human(display_long)|uniprotkb:HSPA1L(gene name)|psi-mi:HSPA1L(display_short)|uniprotkb:Heat shock 70 kDa protein 1-Hom(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_005518.3|ensembl:ENSG00000204390(gene)|ensembl:ENSG00000206383(gene)|ensembl:ENSG00000234258(gene)|ensembl:ENSG00000236251(gene)|ensembl:ENST00000375654(transcript)|ensembl:ENST00000383390(transcript)|ensembl:ENST00000417601(transcript)|ensembl:ENST00000456772(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P34931|rcsb pdb:3GDQ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|uniprotkb:P34931(identity)|genbank_protein_gi:124256496(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:KS02DcMpD2sxSF36hUjKiSdYi4c9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q99615 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|genbank_protein_gi:221219056(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q9UNE7 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q8WXX5 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-2349100|uniprotkb:B2RMW6|ensembl:ENSP00000362041 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dnjc9_human(display_long)|uniprotkb:DNAJC9(gene name)|psi-mi:DNAJC9(display_short)|uniprotkb:DnaJ protein SB73(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_056005.1|ensembl:ENSG00000213551(gene)|ensembl:ENST00000372950(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:Q8WXX5|rcsb pdb:7CIZ|rcsb pdb:7CJ0|go:"GO:0005829"(cytosol)|uniprotkb:Q8WXX5(identity)|genbank_protein_gi:27597059(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:K1fhi/D2XXu0PXipEvxGKWyDMMI9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q9NPY3 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-1755002|uniprotkb:O00274|ensembl:ENSP00000246006 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:c1qr1_human(display_long)|uniprotkb:CD93(gene name)|psi-mi:CD93(display_short)|uniprotkb:C1QR1(gene name synonym)|uniprotkb:MXRA4(gene name synonym)|uniprotkb:Complement component 1 q subcomponent receptor 1(gene name synonym)|uniprotkb:C1q/MBL/SPA receptor(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 4(gene name synonym)|uniprotkb:CDw93(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_036204.2|ensembl:ENSG00000125810(gene)|ensembl:ENST00000246006(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR026823|reactome:R-HSA-6798695|uniprotkb:Q9NPY3(identity)|genbank_protein_gi:88758613(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:UUAqMVWpqxTV5XU50trEv5VVewQ9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q9NXW2 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-358818|uniprotkb:Q9H6H0|uniprotkb:B7Z7I3|ensembl:ENSP00000403313 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:djb12_human(display_long)|uniprotkb:DNAJB12(gene name)|psi-mi:DNAJB12(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_001002762.2|refseq:NP_060096.3|ensembl:ENSG00000148719(gene)|ensembl:ENST00000444643(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034622"|go:"GO:0036503"(ERAD pathway)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0071218"(cellular response to misfolded protein)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR015399(Protein of unknown function DUF1977, DnaJ-like)|interpro:IPR018253|interpro:IPR036869|mint:Q9NXW2|rcsb pdb:2CTP|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q9NXW2(identity)|genbank_protein_gi:194306640(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:kt+aES6+wgXo7o1UhFt4E5w9wTs9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q15773 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:P26196 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N|uniprotkb:P26196(identity)|genbank_protein_gi:164664518(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:O75190 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:P08107 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487|uniprotkb:P08107(identity)|genbank_protein_gi:167466173(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q9NPI6 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q96F86 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393134|imex:IM-22301-1569 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N|uniprotkb:Q96F86(identity)|genbank_protein_gi:19923613(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 intact-crc:988FA0D23A503BCA|rigid:SnDUjIRqNZDeBkdsqA7nFUgBnfI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UL15 uniprotkb:Q9Y6D9 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334 psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393211|imex:IM-22301-1570 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N|uniprotkb:Q9Y6D9(identity)|genbank_protein_gi:62243332(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606 intact-crc:63C3487F46BDE7BA|rigid:tJ3e2CuS46S1oLB/y1DxkyOKmzA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UL15 uniprotkb:Q8TDM6 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 intact:EBI-715138|uniprotkb:Q149N1|uniprotkb:Q5T1H7|uniprotkb:Q5T1H8|uniprotkb:Q6DKG3|uniprotkb:Q86WC0|uniprotkb:Q8TDM7|uniprotkb:Q9UE73|uniprotkb:Q9Y4E3|uniprotkb:A6H8Y3|ensembl:ENSP00000361467|ensembl:ENSP00000484894 psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:dlg5_human(display_long)|uniprotkb:Placenta and prostate DLG(gene name synonym)|uniprotkb:Discs large protein P-dlg(gene name synonym)|uniprotkb:DLG5(gene name)|psi-mi:DLG5(display_short)|uniprotkb:KIAA0583(gene name synonym)|uniprotkb:PDLG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393211|imex:IM-22301-1570 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) refseq:NP_004738.3|refseq:XP_016872403.1|refseq:XP_011538647.1|ensembl:ENSG00000151208(gene)|ensembl:ENSG00000274429(gene)|ensembl:ENST00000372391(transcript)|ensembl:ENST00000614211(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|refseq:XP_006718119.1|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0030901"(midbrain development)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035332"(positive regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045176"(apical protein localization)|go:"GO:0045186"(zonula adherens assembly)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006907(Protein of unknown function DUF622)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR035537|interpro:IPR036028|interpro:IPR036034|mint:Q8TDM6|rcsb pdb:1UIT|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-41450N|uniprotkb:Q8TDM6(identity)|genbank_protein_gi:95089461(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rogid:UmBC3Fli9huOHBiaXBtfPogAQCE9606 intact-crc:63C3487F46BDE7BA|rigid:tJ3e2CuS46S1oLB/y1DxkyOKmzA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UL15 uniprotkb:Q13257 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393211|imex:IM-22301-1570 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N|uniprotkb:Q9UL15(identity)|entrezgene/locuslink:9529(identity)|ddbj/embl/genbank:BC050551(identity) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N|uniprotkb:Q13257(identity)|genbank_protein_gi:4505067(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:63C3487F46BDE7BA|rigid:tJ3e2CuS46S1oLB/y1DxkyOKmzA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9HB71 uniprotkb:Q9H4P4 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-2130266|uniprotkb:B2RBT8|uniprotkb:O75598|intact:EBI-2563208|intact:EBI-11576203|uniprotkb:A6NFW0|ensembl:ENSP00000342755|ensembl:ENSP00000447303|ensembl:ENSP00000484671 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:rnf41_human(display_long)|uniprotkb:RNF41(gene name)|psi-mi:RNF41(display_short)|uniprotkb:FLRF(gene name synonym)|uniprotkb:NRDP1(gene name synonym)|uniprotkb:RING finger protein 41(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NRDP1(gene name synonym)|uniprotkb:SBBI03(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393233|imex:IM-22301-1571 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) refseq:XP_011536036.1|refseq:XP_011536037.1|refseq:NP_001229755.1|refseq:NP_005776.1|refseq:NP_919340.1|refseq:NP_919339.1|refseq:XP_005268618.1|ensembl:ENSG00000181852(gene)|ensembl:ENST00000345093(transcript)|ensembl:ENST00000552656(transcript)|ensembl:ENST00000615206(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015036(USP8 interacting)|interpro:IPR017907|interpro:IPR037255|rcsb pdb:2FZP|rcsb pdb:2GWF|reactome:R-HSA-1358803|reactome:R-HSA-983168|uniprotkb:Q9H4P4(identity)|genbank_protein_gi:338827618(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:jthVZwxUECSdqeJ2jZQ5UL28kDY9606 intact-crc:DE34B45047D0322C|rigid:2Bk+h2iPsQITniw2seWnRw6jHT8 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9HB71 uniprotkb:Q86X55 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393233|imex:IM-22301-1571 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP)|uniprotkb:Q86X55(identity)|genbank_protein_gi:40288288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 intact-crc:DE34B45047D0322C|rigid:2Bk+h2iPsQITniw2seWnRw6jHT8 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:P62258 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|uniprotkb:P62258(identity)|genbank_protein_gi:5803225(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:Q9Y5K6 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-298152|uniprotkb:A6NL34|uniprotkb:Q5VYA3|uniprotkb:Q9UG97|ensembl:ENSP00000352264 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:cd2ap_human(display_long)|uniprotkb:CD2AP(gene name)|psi-mi:CD2AP(display_short)|uniprotkb:Cas ligand with multiple SH3 domains(gene name synonym)|uniprotkb:Adapter protein CMS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) ensembl:ENSG00000198087(gene)|ensembl:ENST00000359314(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031941"(filamentous actin)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9Y5K6|rcsb pdb:2FEI|rcsb pdb:2J6F|rcsb pdb:2J6K|rcsb pdb:2J6O|rcsb pdb:2J7I|rcsb pdb:3AA6|rcsb pdb:3LK4|rcsb pdb:3U23|rcsb pdb:4WCI|rcsb pdb:4X1V|rcsb pdb:7DS6|rcsb pdb:7DS8|reactome:R-HSA-373753|refseq:NP_036252.1|dip:DIP-31807N|uniprotkb:Q9Y5K6(identity)|genbank_protein_gi:11321634(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:T0OYMq1jOCwVMJOxnrPg5Jm4CGw9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:Q04917 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|uniprotkb:Q04917(identity)|genbank_protein_gi:4507951(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:Q96B97 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)|uniprotkb:Q96B97(identity)|genbank_protein_gi:13994242(identity)|ddbj/embl/genbank:BC015806(identity)|entrezgene/locuslink:30011(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:O60256 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-724960|uniprotkb:B7ZKZ1|uniprotkb:Q6IAS2|ensembl:ENSP00000268835|uniprotkb:B4E1M8|uniprotkb:E7EMY2|uniprotkb:B4E329 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:kprb_human(display_long)|uniprotkb:41 kDa phosphoribosypyrophosphate synthetase-associated protein(gene name synonym)|uniprotkb:PRPSAP2(gene name)|psi-mi:PRPSAP2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) refseq:NP_002758.1|refseq:NP_001230865.1|refseq:NP_001230869.1|refseq:NP_001230870.1|refseq:NP_001230871.1|ensembl:ENSG00000141127(gene)|ensembl:ENST00000268835(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|interpro:IPR029057|interpro:IPR029099|rcsb pdb:2JI4|refseq:XP_005256782.1|refseq:XP_005256783.1|refseq:XP_005256786.1|refseq:XP_016880354.1|refseq:XP_016880355.1|refseq:XP_016880356.1|refseq:XP_016880360.1|refseq:XP_016880361.1|refseq:XP_016880362.1|refseq:XP_016880363.1|refseq:XP_016880364.1|refseq:XP_016880365.1|uniprotkb:O60256(identity)|genbank_protein_gi:345478668(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:6sFkRIePKX0zxDEtLbuXM3gPcFQ9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:P62993 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|uniprotkb:P62993(identity)|genbank_protein_gi:4504111(identity)|entrezgene/locuslink:2885(identity)|ddbj/embl/genbank:BC000631(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P22681 uniprotkb:P52907 intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033 intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168 psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym) psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393250|imex:IM-22301-1572 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377|uniprotkb:P22681(identity)|entrezgene/locuslink:867(identity) refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231|uniprotkb:P52907(identity)|genbank_protein_gi:5453597(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606 rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606 intact-crc:BEC412D63571F762|rigid:JOis8FwJPPUzWO2YxJgAWmMFD0g false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:K9JA46 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9392866 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9UQ88 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-373024|uniprotkb:O95227|uniprotkb:O95228|uniprotkb:O96012|uniprotkb:Q12821|uniprotkb:Q12853|uniprotkb:Q12854|uniprotkb:Q5QPR0|uniprotkb:Q5QPR1|uniprotkb:Q5QPR2|uniprotkb:Q9UBC4|uniprotkb:Q9UBI3|uniprotkb:Q9UEI1|uniprotkb:Q9UEI2|uniprotkb:Q9UP53|uniprotkb:Q9UP54|uniprotkb:Q9UP55|uniprotkb:Q9UP56|uniprotkb:Q9UQ86|uniprotkb:Q9UQ87|uniprotkb:Q9UQ89|uniprotkb:Q2TAJ0|ensembl:ENSP00000367900 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cd11a_human(display_long)|uniprotkb:CDK11A(gene name)|psi-mi:CDK11A(display_short)|uniprotkb:PITSLREB(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 2(gene name synonym)|uniprotkb:Galactosyltransferase-associated protein kinase p58/GTA(gene name synonym)|uniprotkb:CDC2L2(gene name synonym)|uniprotkb:CDC2L3(gene name synonym)|uniprotkb:PITSLRE serine/threonine-protein kinase CDC2L2(gene name synonym)|uniprotkb:Cell division protein kinase 11A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_076916.2|refseq:NP_277071.2|refseq:NP_001300825.1|refseq:NP_001300911.1|ensembl:ENSG00000008128(gene)|ensembl:ENST00000378633(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q9UQ88|reactome:R-HSA-380270|uniprotkb:Q9UQ88(identity)|genbank_protein_gi:148763345(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:h30ee1oqCuzFkWhpX9dsmJFl9Y09606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P63208 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N|uniprotkb:P63208(identity)|genbank_protein_gi:25777711(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q92900 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-373471|uniprotkb:O00239|uniprotkb:O43343|uniprotkb:Q86Z25|uniprotkb:Q92842|ensembl:ENSP00000470142 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:rent1_human(display_long)|uniprotkb:UPF1(gene name)|psi-mi:UPF1(display_short)|uniprotkb:RENT1(gene name synonym)|uniprotkb:KIAA0221(gene name synonym)|uniprotkb:ATP-dependent helicase RENT1(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 1(gene name synonym)|uniprotkb:Up-frameshift suppressor 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_002902.2|refseq:NP_001284478.1|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|ensembl:ENSG00000005007(gene)|ensembl:ENST00000599848(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016787"(hydrolase activity)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR018999|interpro:IPR027417|interpro:IPR040812|interpro:IPR041677|interpro:IPR041679|mint:Q92900|rcsb pdb:2GJK|rcsb pdb:2GK6|rcsb pdb:2GK7|rcsb pdb:2IYK|rcsb pdb:2WJV|rcsb pdb:2WJY|rcsb pdb:2XZO|rcsb pdb:2XZP|rcsb pdb:6EJ5|rcsb pdb:6Z3R|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0006406"(mRNA export from nucleus)|dip:DIP-29875N|uniprotkb:Q92900(identity)|genbank_protein_gi:18375673(identity)|ddbj/embl/genbank:BC039817(identity)|entrezgene/locuslink:5976(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:ORqXFPAa7qA8cwM5qcNodIF0q/s9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P25685 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O14920 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N|uniprotkb:O14920(identity)|genbank_protein_gi:299758411(identity)|entrezgene/locuslink:3551(identity)|ddbj/embl/genbank:BC108694(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9H6T3 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P10398 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N|uniprotkb:P10398(identity)|genbank_protein_gi:371875793(identity)|ddbj/embl/genbank:BC007514(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9BW92 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1|uniprotkb:Q9BW92(identity)|genbank_protein_gi:20070344(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P06493 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N|uniprotkb:P06493(identity)|genbank_protein_gi:16306492(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q86SX1 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9392873 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P42684 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N|uniprotkb:P42684(identity)|genbank_protein_gi:209862778(identity) psi-mi:"MI:0469"(intact) - crc64:ED93869BC2B14FAA figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P16591 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1380661|uniprotkb:B4DSQ2|uniprotkb:B2RCR4|uniprotkb:H2FLB8|ensembl:ENSP00000281092 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fer_human(display_long)|uniprotkb:Feline encephalitis virus-related kinase FER(gene name synonym)|uniprotkb:Fujinami poultry sarcoma/Feline sarcoma-related protein Fer(gene name synonym)|uniprotkb:FER(gene name)|psi-mi:FER(display_short)|uniprotkb:TYK3(gene name synonym)|uniprotkb:Proto-oncogene c-Fer(gene name synonym)|uniprotkb:Tyrosine kinase 3(gene name synonym)|uniprotkb:p94-Fer(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_005237.2|refseq:XP_016864719.1|refseq:XP_016864720.1|refseq:NP_001294957.1|refseq:NP_001294960.1|refseq:NP_001294967.1|refseq:XP_011541573.1|ensembl:ENSG00000151422(gene)|ensembl:ENST00000281092(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033007"(negative regulation of mast cell activation involved in immune response)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0036119"(response to platelet-derived growth factor)|go:"GO:0038028"(insulin receptor signaling pathway via phosphatidylinositol 3-kinase)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050904"(diapedesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016250(Tyrosine-protein kinase, Fes/Fps)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027267|interpro:IPR028539|interpro:IPR031160|interpro:IPR035849|interpro:IPR036860|interpro:IPR037452|mint:P16591|rcsb pdb:2KK6|rcsb pdb:6KC4|reactome:R-HSA-1433557|uniprotkb:P16591(identity)|genbank_protein_gi:119964721(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:De5RYVRGihPHGxaflmxR8W9jC8M9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P52948 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-295727|uniprotkb:Q8IUT2|uniprotkb:Q8WYB0|uniprotkb:Q96E54|uniprotkb:Q9H3Q4|uniprotkb:Q9NT02|uniprotkb:Q9UF57|uniprotkb:Q9UHX0|uniprotkb:Q9Y6J4|uniprotkb:Q9Y6J5|ensembl:ENSP00000352091 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:nup98_human(display_long)|uniprotkb:NUP98(gene name)|psi-mi:NUP98(display_short)|uniprotkb:ADAR2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_005378.4|refseq:NP_057404.2|refseq:NP_624357.1|refseq:NP_624358.2|ensembl:ENST00000324932|ensembl:ENSP00000316032|ensembl:ENST00000355260|ensembl:ENSP00000347404|ensembl:ENSP00000352091|ensembl:ENST00000397004|ensembl:ENSP00000380199|ensembl:ENST00000397007|ensembl:ENSP00000380202|dip:DIP-32484N|ensembl:ENSG00000110713(gene)|ensembl:ENST00000359171(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007230(Peptidase S59, nucleoporin)|interpro:IPR021967|interpro:IPR036903|interpro:IPR037637|interpro:IPR037665|mint:P52948|rcsb pdb:1KO6|rcsb pdb:2Q5X|rcsb pdb:2Q5Y|rcsb pdb:3MMY|rcsb pdb:4OWR|rcsb pdb:5A9Q|rcsb pdb:6BZM|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025|uniprotkb:P52948(identity)|genbank_protein_gi:21264365(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:aW9NaKgLZti0wLEiVQogGukcWdE9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O15111 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N|uniprotkb:O15111(identity)|entrezgene/locuslink:1147(identity)|ddbj/embl/genbank:BC092514(identity)|genbank_protein_gi:62241001(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:FVB/gXjSBTB9hdq9pycQogxesms9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q96GD4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N|uniprotkb:Q96GD4(identity)|ddbj/embl/genbank:BC009751(identity)|entrezgene/locuslink:9212(identity)|genbank_protein_gi:378786658(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q02790 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q08752 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P11802 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069|uniprotkb:P11802(identity)|genbank_protein_gi:4502735(identity)|ddbj/embl/genbank:BC003644(identity)|entrezgene/locuslink:1019(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9UNE7 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q8WXH0 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2372294|uniprotkb:Q540G1|uniprotkb:Q8N1S3|uniprotkb:Q8NF49|uniprotkb:Q8TER7|uniprotkb:Q8WWW3|uniprotkb:Q8WWW4|uniprotkb:Q8WWW5|uniprotkb:Q8WXH1|uniprotkb:Q9NU50|uniprotkb:Q9UFQ4|uniprotkb:Q9Y2L4|uniprotkb:Q9Y4R1|uniprotkb:Q86YP9|uniprotkb:B4DND7|uniprotkb:B4DPR6|uniprotkb:I6XXQ5|ensembl:ENSP00000341781 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:syne2_human(display_long)|uniprotkb:SYNE2(gene name)|psi-mi:SYNE2(display_short)|uniprotkb:KIAA1011(gene name synonym)|uniprotkb:NUA(gene name synonym)|uniprotkb:Nuclear envelope spectrin repeat protein 2(gene name synonym)|uniprotkb:Synaptic nuclear envelope protein 2(gene name synonym)|uniprotkb:Nucleus and actin connecting element protein(gene name synonym)|uniprotkb:KASH domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSP00000344528|ensembl:ENSP00000341781|ensembl:ENST00000358025|ensembl:ENSP00000350719|ensembl:ENST00000458046|ensembl:ENSP00000391937|ensembl:ENST00000555002|ensembl:ENSP00000450831|ensembl:ENST00000341472|refseq:NP_055995.4|refseq:NP_878914.1|refseq:NP_878917.1|refseq:NP_878918.2|dip:DIP-53409N|ensembl:ENSG00000054654(gene)|ensembl:ENST00000344113(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031981"(nuclear lumen)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0051015"(actin filament binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR012315(Klarsicht/ANC-1/syne-1 homology)|interpro:IPR018159|interpro:IPR030266|interpro:IPR036872|rcsb pdb:4DXS|rcsb pdb:4FI9|rcsb pdb:6XF1|reactome:R-HSA-1221632|uniprotkb:Q8WXH0(identity)|genbank_protein_gi:118918403(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:wLHWOXR+dUHkcs93g+F2av/9wm49606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P53041 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P08238 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O94966 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q92990 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-726150|uniprotkb:Q9BVE8|uniprotkb:Q5VVC3|ensembl:ENSP00000359385 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:glmn_human(display_long)|uniprotkb:FAP68(gene name synonym)|uniprotkb:FKBP-associated protein(gene name synonym)|uniprotkb:FK506-binding protein-associated protein(gene name synonym)|uniprotkb:GLMN(gene name)|psi-mi:GLMN(display_short)|uniprotkb:FAP48(gene name synonym)|uniprotkb:VMGLOM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_444504.1|refseq:XP_011538848.1|refseq:NP_001306612.1|ensembl:ENSG00000174842(gene)|ensembl:ENST00000370360(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005171"(hepatocyte growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|interpro:IPR013877(Protein of unknown function DUF1760, fungi)|interpro:IPR019516|rcsb pdb:4F52|reactome:R-HSA-983168|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|uniprotkb:Q92990(identity)|genbank_protein_gi:16933537(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:ZpLZbiPwlYDPX8C767kVrbKmEmo9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9H3U1 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1|uniprotkb:Q9H3U1(identity)|ddbj/embl/genbank:BC037992(identity)|genbank_protein_gi:29725607(identity)|entrezgene/locuslink:55898(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9Y6K9 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-81279|intact:EBI-356130|uniprotkb:Q7LBY6|uniprotkb:Q7Z7F1|ensembl:ENSP00000471166|ensembl:ENSP00000479662 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:nemo_human(display_long)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:FIP-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001308325.1|refseq:NP_001308326.1|refseq:NP_001093326.2|refseq:NP_001093327.1|refseq:NP_001138727.1|refseq:NP_003630.1|dip:DIP-27528N|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:Q9Y6K9|rcsb pdb:2JVX|rcsb pdb:2JVY|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:3CL3|rcsb pdb:3FX0|rcsb pdb:4BWN|rcsb pdb:5AAY|rcsb pdb:5LDE|rcsb pdb:6MI3|rcsb pdb:6MI4|rcsb pdb:6YEK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-4755510|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|uniprotkb:Q9Y6K9(identity)|genbank_protein_gi:153792133(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9H7B4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-347919|ensembl:ENSP00000419184|uniprotkb:Q86TL8|uniprotkb:Q8N5Z6|uniprotkb:Q96AI5|uniprotkb:B1AN38|uniprotkb:A8K0P0 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:smyd3_human(display_long)|uniprotkb:SMYD3(gene name)|psi-mi:SMYD3(display_short)|uniprotkb:ZMYND1(gene name synonym)|uniprotkb:ZNFN3A1(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 1(gene name synonym)|uniprotkb:SET and MYND domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000185420(gene)|ensembl:ENST00000490107(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0014904"(myotube cell development)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001214(SET)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR025805|interpro:IPR044420|mint:Q9H7B4|rcsb pdb:3MEK|rcsb pdb:3OXF|rcsb pdb:3OXG|rcsb pdb:3OXL|rcsb pdb:3PDN|rcsb pdb:3QWP|rcsb pdb:3RU0|rcsb pdb:5CCL|rcsb pdb:5CCM|rcsb pdb:5EX0|rcsb pdb:5EX3|rcsb pdb:5HI7|rcsb pdb:5HQ8|rcsb pdb:5V37|rcsb pdb:5XXG|rcsb pdb:5XXJ|rcsb pdb:5YJO|rcsb pdb:6IJL|rcsb pdb:6O9O|rcsb pdb:6P6G|rcsb pdb:6P6K|rcsb pdb:5XXD|rcsb pdb:6P7Z|rcsb pdb:6PAF|rcsb pdb:6YUH|rcsb pdb:7BJ1|reactome:R-HSA-3214841|refseq:XP_011542559.1|refseq:NP_001161212.1|refseq:NP_073580.1|dip:DIP-32653N|uniprotkb:Q9H7B4(identity)|genbank_protein_gi:267844824(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:gKISZLHkhKTIVn2O646c4OQhLzc9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9UIM3 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q14247 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-351886|intact:EBI-3959948|ensembl:ENSP00000301843|ensembl:ENSP00000500756|uniprotkb:Q8N707|uniprotkb:Q96H99 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:src8_human(display_long)|uniprotkb:CTTN(gene name)|psi-mi:CTTN(display_short)|uniprotkb:EMS1(gene name synonym)|uniprotkb:Amplaxin(gene name synonym)|uniprotkb:Oncogene EMS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_005222.2|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|interpro:IPR036028|mint:Q14247|rcsb pdb:1X69|rcsb pdb:2D1X|reactome:R-HSA-5627123|reactome:R-HSA-8856828|ensembl:ENSG00000085733(gene)|ensembl:ENSG00000288401(gene)|ensembl:ENST00000301843(transcript)|ensembl:ENST00000671805(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|refseq:NP_001171669.1|refseq:NP_612632.1|dip:DIP-33190N|uniprotkb:Q14247(identity)|genbank_protein_gi:20357552(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:uzhAnL5Fu9Mgg9/LWeNiaYIwNVU9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q8N5M4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2851213|uniprotkb:Q8WYY7|ensembl:ENSP00000325266|ensembl:ENSP00000434340 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ttc9c_human(display_long)|uniprotkb:TTC9C(gene name)|psi-mi:TTC9C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001305745.1|refseq:NP_776171.1|refseq:NP_001305741.1|refseq:NP_001305742.1|refseq:NP_001305743.1|refseq:NP_001305744.1|ensembl:ENSG00000162222(gene)|ensembl:ENST00000316461(transcript)|ensembl:ENST00000532583(transcript)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|uniprotkb:Q8N5M4(identity)|genbank_protein_gi:28603842(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:IazckGbo0Z5cqr/m7hx7Av7BJlU9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P52272 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732|uniprotkb:P52272(identity)|genbank_protein_gi:14141152(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O95433 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q15785 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|uniprotkb:Q15785(identity)|genbank_protein_gi:21361356(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P04049 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|ddbj/embl/genbank:BC018119(identity)|genbank_protein_gi:4506401(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O00170 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q59F66 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-9393291 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:q59f66_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|refseq:NP_001091974.1|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016787"(hydrolase activity)|uniprotkb:Q59F66(identity)|genbank_protein_gi:148613856(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:Fe+C/VPfIYgyCEz+CbaHgUCl9uA9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:P78406 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-724495|uniprotkb:O15306|uniprotkb:Q3SYL7|uniprotkb:Q5TCH8|uniprotkb:Q6V708|uniprotkb:Q9H100|uniprotkb:Q9NQM6|ensembl:ENSP00000360286|ensembl:ENSP00000379181|ensembl:ENSP00000379182|uniprotkb:A8K882 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:rae1l_human(display_long)|uniprotkb:mRNA-associated protein mrnp 41(gene name synonym)|uniprotkb:Rae1 protein homolog(gene name synonym)|uniprotkb:RAE1(gene name)|psi-mi:RAE1(display_short)|uniprotkb:MRNP41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_001015885.1|refseq:NP_003601.1|ensembl:ENSG00000101146(gene)|ensembl:ENST00000371242(transcript)|ensembl:ENST00000395840(transcript)|ensembl:ENST00000395841(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037631|mint:P78406|rcsb pdb:3MMY|rcsb pdb:4OWR|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|interpro:IPR019775|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|refseq:XP_011527390.1|refseq:XP_011527391.1|refseq:XP_005260639.2|dip:DIP-41063N|uniprotkb:P78406(identity)|genbank_protein_gi:4506399(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:JK4Y5p3WUcHFXBXyhhqCnDnG49c9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q13451 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q9UHD1 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:Q99615 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|genbank_protein_gi:221219056(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q16543 uniprotkb:O95801 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393294|imex:IM-22301-1573 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 intact-crc:D6A94A55D6E67CA8|rigid:AbFglzIxbMFft6l4WD+W4F88mvs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q92990 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-726150|uniprotkb:Q9BVE8|uniprotkb:Q5VVC3|ensembl:ENSP00000359385 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:glmn_human(display_long)|uniprotkb:FAP68(gene name synonym)|uniprotkb:FKBP-associated protein(gene name synonym)|uniprotkb:FK506-binding protein-associated protein(gene name synonym)|uniprotkb:GLMN(gene name)|psi-mi:GLMN(display_short)|uniprotkb:FAP48(gene name synonym)|uniprotkb:VMGLOM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_444504.1|refseq:XP_011538848.1|refseq:NP_001306612.1|ensembl:ENSG00000174842(gene)|ensembl:ENST00000370360(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005171"(hepatocyte growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|interpro:IPR013877(Protein of unknown function DUF1760, fungi)|interpro:IPR019516|rcsb pdb:4F52|reactome:R-HSA-983168|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|uniprotkb:Q92990(identity)|genbank_protein_gi:16933537(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:ZpLZbiPwlYDPX8C767kVrbKmEmo9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q15785 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|uniprotkb:Q15785(identity)|genbank_protein_gi:21361356(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q13451 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:K9JA46 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-9392866 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:P53041 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:P08708 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-358255|uniprotkb:B2R4U4|intact:EBI-8012092|intact:EBI-11603362|intact:MINT-8395037|uniprotkb:P0CW22|ensembl:ENSP00000483755|ensembl:ENSP00000498019 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:rs17_human(display_long)|uniprotkb:RPS17(gene name)|psi-mi:RPS17(display_short)|uniprotkb:Small ribosomal subunit protein eS17(gene name synonym)|uniprotkb:RPS17L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_001012.1|ensembl:ENSG00000182774(gene)|ensembl:ENSG00000278229(gene)|ensembl:ENST00000617731(transcript)|ensembl:ENST00000647841(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P08708|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|go:"GO:0034101"(erythrocyte homeostasis)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:P0CW22(identity)|genbank_protein_gi:312284072(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:st+xQCXdSObiy6cJD1cSx869V289606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:P31948 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q9NZQ9 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-9393504|uniprotkb:Q5JR83|uniprotkb:Q8WVL3|uniprotkb:Q9UKH2|uniprotkb:B7Z6N9|ensembl:ENSP00000295314 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:tmod4_human(display_long)|uniprotkb:TMOD4(gene name)|psi-mi:TMOD4(display_short)|uniprotkb:Skeletal muscle tropomodulin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:XP_011507751.1|refseq:XP_016856578.1|refseq:NP_037485.2|ensembl:ENSG00000163157(gene)|ensembl:ENST00000295314(transcript)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|interpro:IPR004934(Tropomodulin)|interpro:IPR030129|interpro:IPR032675|reactome:R-HSA-390522|uniprotkb:Q9NZQ9(identity)|genbank_protein_gi:156415984(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:ZJGCNYqt6P1kqXDoSEjEhDwksd09606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:P08238 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q9UHD1 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:O94966 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q86SX1 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-9392873 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:P62081 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-354360|uniprotkb:Q6IPH1|uniprotkb:P23821|uniprotkb:P24818|uniprotkb:Q57Z92|ensembl:ENSP00000385018|ensembl:ENSP00000385286|ensembl:ENSP00000495273|ensembl:ENSP00000496654|ensembl:ENSP00000496757 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:rs7_human(display_long)|uniprotkb:RPS7(gene name)|psi-mi:RPS7(display_short)|uniprotkb:Small ribosomal subunit protein eS7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_001002.1|ensembl:ENSG00000171863(gene)|ensembl:ENST00000403564(transcript)|ensembl:ENST00000406376(transcript)|ensembl:ENST00000462576(transcript)|ensembl:ENST00000645674(transcript)|ensembl:ENST00000646909(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030154"(cell differentiation)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0045202"(synapse)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050821"(protein stabilization)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000554(Ribosomal protein S7e)|mint:P62081|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|rcsb pdb:6G4S|uniprotkb:P62081(identity)|genbank_protein_gi:4506741(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:l4aG6I34lmzYhNapbdv2CAAwRwg9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q16543 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q9UNE7 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:O14980 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N|uniprotkb:O14980(identity)|entrezgene/locuslink:7514(identity)|ddbj/embl/genbank:BC032847(identity)|genbank_protein_gi:4507943(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:O95801 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L3B6 uniprotkb:Q02790 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393511|imex:IM-22301-1574 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:6FEACBE8EEE62F96|rigid:Phz3GKCPPaFvOsa1qikB5Pl7N9U false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:P08238 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:Q86SX1 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-9392873 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:P68363 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328|uniprotkb:P68363(identity)|genbank_protein_gi:57013276(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:Q02790 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:Q9HAV4 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6|uniprotkb:Q9HAV4(identity)|genbank_protein_gi:22748937(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:Q9BW92 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1|uniprotkb:Q9BW92(identity)|genbank_protein_gi:20070344(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:Q15785 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|uniprotkb:Q15785(identity)|genbank_protein_gi:21361356(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHD1 uniprotkb:K9JA46 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 intact:EBI-9392866 psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393609|imex:IM-22301-1575 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:28496CC755BF497F|rigid:Z6P9pz2E5CNzmmOQSGBHmE74pw4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NPI6 uniprotkb:Q96F86 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393656|imex:IM-22301-1576 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N|uniprotkb:Q96F86(identity)|genbank_protein_gi:19923613(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 intact-crc:531CD8F7DD430C67|rigid:Mo1NFpHixRgHuV57lgttXFZc+0o false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NPI6 uniprotkb:P26196 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393656|imex:IM-22301-1576 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N|uniprotkb:P26196(identity)|genbank_protein_gi:164664518(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 intact-crc:531CD8F7DD430C67|rigid:Mo1NFpHixRgHuV57lgttXFZc+0o false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NPI6 uniprotkb:Q6P2E9 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393656|imex:IM-22301-1576 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N|uniprotkb:Q6P2E9(identity)|genbank_protein_gi:45827771(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 intact-crc:531CD8F7DD430C67|rigid:Mo1NFpHixRgHuV57lgttXFZc+0o false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NPI6 uniprotkb:Q8IU60 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393656|imex:IM-22301-1576 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|uniprotkb:Q8IU60(identity)|genbank_protein_gi:31542498(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 intact-crc:531CD8F7DD430C67|rigid:Mo1NFpHixRgHuV57lgttXFZc+0o false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NPI6 uniprotkb:Q8IZD4 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393656|imex:IM-22301-1576 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 intact-crc:531CD8F7DD430C67|rigid:Mo1NFpHixRgHuV57lgttXFZc+0o false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:Q96AV8 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|uniprotkb:Q96AV8(identity)|genbank_protein_gi:145580626(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:P35813 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972|uniprotkb:P35813(identity)|genbank_protein_gi:10337595(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:Q6P2E9 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N|uniprotkb:Q6P2E9(identity)|genbank_protein_gi:45827771(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:P26196 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N|uniprotkb:P26196(identity)|genbank_protein_gi:164664518(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:Q9NPI6 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N|uniprotkb:Q9NPI6(identity)|genbank_protein_gi:291327466(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IZD4 uniprotkb:Q96F86 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393687|imex:IM-22301-1577 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1|uniprotkb:Q8IZD4(identity)|entrezgene/locuslink:196513(identity)|genbank_protein_gi:40548403(identity)|ddbj/embl/genbank:BC043437(identity) refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N|uniprotkb:Q96F86(identity)|genbank_protein_gi:19923613(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 intact-crc:49DC137698B2F6ED|rigid:aaYaoDHIqp/GyBUBG82arWDBe18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P34931 uniprotkb:Q99615 intact:EBI-354912|uniprotkb:O75634|uniprotkb:Q2HXR3|uniprotkb:Q8NE72|uniprotkb:A6NNB0|uniprotkb:Q96QC9|uniprotkb:Q9UQM1|uniprotkb:B0UXW8|ensembl:ENSP00000364805|ensembl:ENSP00000372881|ensembl:ENSP00000396486|ensembl:ENSP00000408347 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:hs71l_human(display_long)|uniprotkb:HSPA1L(gene name)|psi-mi:HSPA1L(display_short)|uniprotkb:Heat shock 70 kDa protein 1-Hom(gene name synonym) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393778|imex:IM-22301-1579 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005518.3|ensembl:ENSG00000204390(gene)|ensembl:ENSG00000206383(gene)|ensembl:ENSG00000234258(gene)|ensembl:ENSG00000236251(gene)|ensembl:ENST00000375654(transcript)|ensembl:ENST00000383390(transcript)|ensembl:ENST00000417601(transcript)|ensembl:ENST00000456772(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P34931|rcsb pdb:3GDQ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|uniprotkb:P34931(identity)|genbank_protein_gi:124256496(identity) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1|uniprotkb:Q99615(identity)|ddbj/embl/genbank:BC011837(identity)|entrezgene/locuslink:7266(identity)|genbank_protein_gi:221219056(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:KS02DcMpD2sxSF36hUjKiSdYi4c9606 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:20C9159DD434BED7|rigid:Z9mZMfIASa82ttc0PtMcUJycGQc false - flag tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q6NSI4 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-8634209|ensembl:ENSP00000361628|uniprotkb:Q9H7W5|uniprotkb:Q6PHY5|uniprotkb:Q6PII9|intact:MINT-8162145|uniprotkb:Q9NWA6|uniprotkb:Q5JQS1|uniprotkb:Q4G0L7|uniprotkb:H7BY89|uniprotkb:Q5JRF9|uniprotkb:Q6PJU8 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:radx_human(display_long)|uniprotkb:RADX(gene name)|psi-mi:RADX(display_short)|uniprotkb:CXorf57(gene name synonym)|uniprotkb:RPA-related and RAD51-antagonist, X-chromosome(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSG00000147231(gene)|ensembl:ENST00000372548(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005657"(replication fork)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR040893|refseq:NP_060485.4|refseq:NP_001171711.1|uniprotkb:Q6NSI4(identity)|entrezgene/locuslink:55086(identity)|genbank_protein_gi:193804923(identity)|ddbj/embl/genbank:BC070110(identity) psi-mi:"MI:0469"(intact) - comment:mint figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:pUlTaH5Wq19LDuJp7qGlWFpa0q09606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q3ZCQ8 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-355175|uniprotkb:Q6QA00|uniprotkb:Q96FJ5|uniprotkb:Q96GY2|uniprotkb:Q9H370|intact:EBI-2554785|uniprotkb:Q330K1|ensembl:ENSP00000475531 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:tim50_human(display_long)|uniprotkb:TIMM50(gene name)|psi-mi:TIMM50(display_short)|uniprotkb:TIM50(gene name synonym)|uniprotkb:PRO1512(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) refseq:NP_001001563.1|ensembl:ENSG00000105197(gene)|ensembl:ENST00000607714(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR004274(NLI interacting factor)|interpro:IPR023214|interpro:IPR027111|interpro:IPR036412|mint:Q3ZCQ8|reactome:R-HSA-1268020|refseq:NP_001316488.1|dip:DIP-34058N|uniprotkb:Q3ZCQ8(identity)|genbank_protein_gi:48526509(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:fOPV33h12YhAq9jj0bVno01Q+6g9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q9BUF5 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1|uniprotkb:Q9BUF5(identity)|genbank_protein_gi:14210536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:P31689 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-347834|ensembl:ENSP00000369127|uniprotkb:Q5T7Q0|uniprotkb:Q86TL9 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:dnja1_human(display_long)|uniprotkb:DNAJA1(gene name)|psi-mi:DNAJA1(display_short)|uniprotkb:DNAJ2(gene name synonym)|uniprotkb:HDJ2(gene name synonym)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:HSPF4(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Human DnaJ protein 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:HSDJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSG00000086061(gene)|ensembl:ENST00000330899(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P31689|rcsb pdb:2LO1|rcsb pdb:2M6Y|reactome:R-HSA-3371497|rcsb pdb:6E8M|refseq:NP_001530.1|uniprotkb:P31689(identity)|genbank_protein_gi:4504511(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:YEHeLHYaG2ON2gwuFfqt9Le1Drg9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:P04350 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|genbank_protein_gi:21361322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q13015 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-6269719|ensembl:ENSP00000357917 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:af1q_human(display_long)|uniprotkb:MLLT11(gene name)|psi-mi:MLLT11(display_short)|uniprotkb:AF1Q(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSG00000213190(gene)|ensembl:ENST00000368921(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR026778|interpro:IPR033461|mint:Q13015|refseq:NP_006809.1|uniprotkb:Q13015(identity)|genbank_protein_gi:5802968(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:23mnJAG1OcDgM7eT2rTi1Gv0ZgA9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:P60891 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-749195|uniprotkb:P09329|uniprotkb:B2R6T7|uniprotkb:B1ALA8|uniprotkb:B4DNL6|uniprotkb:D3DUX6|ensembl:ENSP00000361512 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:prps1_human(display_long)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) refseq:NP_001191331.1|refseq:NP_002755.1|ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006221"(pyrimidine nucleotide biosynthetic process)|go:"GO:0007399"(nervous system development)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046101"(hypoxanthine biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|go:"GO:0006144"(purine nucleobase metabolic process)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|rcsb pdb:2H06|rcsb pdb:2H07|rcsb pdb:2H08|rcsb pdb:2HCR|rcsb pdb:3EFH|rcsb pdb:3S5J|rcsb pdb:4F8E|rcsb pdb:4LYG|rcsb pdb:4LZN|rcsb pdb:4LZO|rcsb pdb:4M0P|rcsb pdb:4M0U|reactome:R-HSA-73843|dip:DIP-61999N|uniprotkb:P60891(identity)|genbank_protein_gi:4506127(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:+Hih2M7JLTsjEglauBlPj182h9M9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:O60884 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|genbank_protein_gi:5031741(identity)|ddbj/embl/genbank:BC013044(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q71U36 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WW22 uniprotkb:Q14249 intact:EBI-2555157|uniprotkb:Q8N7P2|uniprotkb:Q6AW87|ensembl:ENSP00000339581|ensembl:ENSP00000378321|uniprotkb:E9PDM9|uniprotkb:Q8N5Z4 intact:EBI-9369928|uniprotkb:Q9BSP2|uniprotkb:Q5T281|intact:EBI-28985943|ensembl:ENSP00000361725 psi-mi:dnja4_human(display_long)|uniprotkb:DNAJA4(gene name)|psi-mi:DNAJA4(display_short) psi-mi:nucg_human(display_long)|uniprotkb:ENDOG(gene name)|psi-mi:ENDOG(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393722|imex:IM-22301-1578 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123654.1|refseq:NP_001123655.1|refseq:NP_061072.3|ensembl:ENSG00000140403(gene)|ensembl:ENST00000343789(transcript)|ensembl:ENST00000394852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:Q8WW22|reactome:R-HSA-3371497|refseq:XP_006720664.1|refseq:XP_005254592.1|uniprotkb:Q8WW22(identity)|ddbj/embl/genbank:BC021720(identity)|entrezgene/locuslink:55466(identity) ensembl:ENSP00000361725|refseq:NP_004426.2|ensembl:ENSG00000167136(gene)|ensembl:ENST00000372642(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006310"(DNA recombination)|go:"GO:0007568"(aging)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0032355"(response to estradiol)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036475"(neuron death in response to oxidative stress)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901300"(positive regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR018524|interpro:IPR020821|interpro:IPR040255|uniprotkb:Q14249(identity)|ddbj/embl/genbank:BC004922(identity)|genbank_protein_gi:53759134(identity)|entrezgene/locuslink:2021(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:GIrkxgRGaQvFml49F9iHH07gqTo9606 rogid:MpJuKVk3ISxp3KzgZrCGkfe/VfA9606 intact-crc:A3B7A872C3FF70F3|rigid:ewAhyrbffRkQpgYWfv5c7Q8NOuI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q9Y2Z0 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q86SX1 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-9392873 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q9UK45 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-348372|ensembl:ENSP00000252622 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:lsm7_human(display_long)|uniprotkb:LSM7(gene name)|psi-mi:LSM7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) refseq:NP_057283.1|interpro:IPR017132(U6 snRNA-associated Sm-like protein LSm7)|interpro:IPR044641|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|ensembl:ENSG00000130332(gene)|ensembl:ENST00000252622(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|dip:DIP-31129N|uniprotkb:Q9UK45(identity)|genbank_protein_gi:7706423(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:vT1gI3yzYl37cX++CUGdJowAL909606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q15185 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q16543 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q9HB71 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q9UHD1 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:O95433 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:P08238 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:S4R435 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-9393793|ensembl:ENSP00000475027 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:s4r435_human(display_long)|uniprotkb:RPS10-NUDT3(gene name)|psi-mi:RPS10-NUDT3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) ensembl:ENSG00000270800(gene)|ensembl:ENST00000605528(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|interpro:IPR005326(Plectin/S10, N-terminal)|interpro:IPR036388|interpro:IPR037447|uniprotkb:S4R435(identity)|genbank_protein_gi:321117084(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:WnRk0dhEWwh5lKKFLfaJmMkhRVY9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:Q92990 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-726150|uniprotkb:Q9BVE8|uniprotkb:Q5VVC3|ensembl:ENSP00000359385 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:glmn_human(display_long)|uniprotkb:FAP68(gene name synonym)|uniprotkb:FKBP-associated protein(gene name synonym)|uniprotkb:FK506-binding protein-associated protein(gene name synonym)|uniprotkb:GLMN(gene name)|psi-mi:GLMN(display_short)|uniprotkb:FAP48(gene name synonym)|uniprotkb:VMGLOM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) refseq:NP_444504.1|refseq:XP_011538848.1|refseq:NP_001306612.1|ensembl:ENSG00000174842(gene)|ensembl:ENST00000370360(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005171"(hepatocyte growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|interpro:IPR013877(Protein of unknown function DUF1760, fungi)|interpro:IPR019516|rcsb pdb:4F52|reactome:R-HSA-983168|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|uniprotkb:Q92990(identity)|genbank_protein_gi:16933537(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:ZpLZbiPwlYDPX8C767kVrbKmEmo9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:O94966 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q02790 uniprotkb:K9JA46 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 intact:EBI-9392866 psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393797|imex:IM-22301-1580 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2017/06/29 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:44987E9D4B508A67|rigid:sXUHso3tu6oL1AW5ciO4JE+H0aQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9UL18 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-527363|uniprotkb:Q5TA57|uniprotkb:Q6P4S0|ensembl:ENSP00000362300|ensembl:ENSP00000501450 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ago1_human(display_long)|uniprotkb:AGO1(gene name)|psi-mi:AGO1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:EIF2C1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Putative RNA-binding protein Q99(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) dip:DIP-29193N|refseq:NP_036331.1|ensembl:ENSG00000092847(gene)|ensembl:ENST00000373204(transcript)|ensembl:ENST00000674304(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9UL18|rcsb pdb:1SI2|rcsb pdb:1SI3|rcsb pdb:4KRE|rcsb pdb:4KRF|rcsb pdb:4KXT|rcsb pdb:5W6V|reactome:R-HSA-1912408|reactome:R-HSA-203927|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426486|reactome:R-HSA-426496|reactome:R-HSA-5578749|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|refseq:NP_001304051.1|refseq:NP_001304052.1|uniprotkb:Q9UL18(identity)|genbank_protein_gi:6912352(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9UKV8 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-528269|uniprotkb:Q8TCZ5|uniprotkb:Q8WV58|uniprotkb:Q96ID1|ensembl:ENSP00000220592 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ago2_human(display_long)|uniprotkb:AGO2(gene name)|psi-mi:AGO2(display_short)|uniprotkb:Argonaute RISC catalytic component 2(gene name synonym)|uniprotkb:EIF2C2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 2(gene name synonym)|uniprotkb:PAZ Piwi domain protein(gene name synonym)|uniprotkb:Protein slicer(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001158095.1|refseq:NP_036286.2|rcsb pdb:5T7B|rcsb pdb:5WEA|rcsb pdb:6CBD|rcsb pdb:6MDZ|rcsb pdb:6MFN|rcsb pdb:6MFR|rcsb pdb:6N4O|rcsb pdb:6NIT|rcsb pdb:6RA4|rcsb pdb:7C6B|rcsb pdb:7D7U|reactome:R-HSA-1912408|reactome:R-HSA-203927|reactome:R-HSA-4086398|reactome:R-HSA-426486|reactome:R-HSA-426496|reactome:R-HSA-5578749|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8934593|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|rcsb pdb:4F3T|rcsb pdb:4OLA|rcsb pdb:4OLB|rcsb pdb:4W5N|rcsb pdb:4W5O|rcsb pdb:4W5Q|rcsb pdb:4W5R|rcsb pdb:4W5T|rcsb pdb:4Z4C|rcsb pdb:4Z4D|rcsb pdb:4Z4E|rcsb pdb:4Z4F|rcsb pdb:4Z4G|rcsb pdb:4Z4H|rcsb pdb:4Z4I|rcsb pdb:5JS1|rcsb pdb:3QX9|rcsb pdb:5JS2|rcsb pdb:5KI6|ensembl:ENSG00000123908(gene)|ensembl:ENST00000220592(transcript)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0030425"(dendrite)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035194"(post-transcriptional gene silencing by RNA)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035279"(miRNA-mediated gene silencing by mRNA destabilization)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0045975"(positive regulation of translation, ncRNA-mediated)|go:"GO:0046872"(metal ion binding)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0070062"(extracellular exosome)|go:"GO:0070551"(endoribonuclease activity, cleaving siRNA-paired mRNA)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090624"(endoribonuclease activity, cleaving miRNA-paired mRNA)|go:"GO:0090625"(mRNA destabilization-mediated gene silencing by siRNA)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR028602|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9UKV8|rcsb pdb:3LUC|rcsb pdb:3LUD|rcsb pdb:3LUG|rcsb pdb:3LUH|rcsb pdb:3LUJ|rcsb pdb:3LUK|rcsb pdb:3QX8|dip:DIP-29194N|uniprotkb:Q9UKV8(identity)|genbank_protein_gi:29171734(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:8GU8wsz9kTG2ViT7pP7uQyYTVsc9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P04150 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-493507|uniprotkb:P04151|uniprotkb:Q53EP5|uniprotkb:Q6N0A4|uniprotkb:B0LPG8|uniprotkb:D3DQF4|uniprotkb:A0ZXF9|uniprotkb:F5ATB7|ensembl:ENSP00000343205|ensembl:ENSP00000377977|ensembl:ENSP00000427672 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:gcr_human(display_long)|uniprotkb:Nuclear receptor subfamily 3 group C member 1(gene name synonym)|uniprotkb:NR3C1(gene name)|psi-mi:NR3C1(display_short)|uniprotkb:GRL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_000167.1|refseq:NP_001018084.1|refseq:NP_001018085.1|refseq:NP_001018086.1|refseq:NP_001018087.1|refseq:NP_001018661.1|refseq:NP_001019265.1|refseq:NP_001191187.1|refseq:NP_001191188.1|refseq:NP_001191189.1|refseq:NP_001191190.1|refseq:NP_001191191.1|refseq:NP_001191192.1|refseq:NP_001191193.1|refseq:XP_005268476.1|refseq:XP_005268477.1|refseq:XP_005268479.1|refseq:XP_005268480.1|ensembl:ENSG00000113580(gene)|ensembl:ENST00000343796(transcript)|ensembl:ENST00000394464(transcript)|ensembl:ENST00000503201(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0004883"(glucocorticoid receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007165"(signal transduction)|rcsb pdb:5E69|rcsb pdb:5E6A|rcsb pdb:5E6B|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|rcsb pdb:5E6C|rcsb pdb:5E6D|go:"GO:0019901"(protein kinase binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990239"(steroid hormone binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001409(Glucocorticoid receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P04150|rcsb pdb:1M2Z|rcsb pdb:1NHZ|rcsb pdb:1P93|rcsb pdb:3BQD|rcsb pdb:3CLD|rcsb pdb:3E7C|rcsb pdb:3H52|rcsb pdb:3K22|rcsb pdb:3K23|rcsb pdb:4CSJ|rcsb pdb:4HN5|rcsb pdb:4HN6|rcsb pdb:4LSJ|rcsb pdb:4MDD|rcsb pdb:4P6W|rcsb pdb:4P6X|rcsb pdb:4UDC|rcsb pdb:4UDD|rcsb pdb:5CBX|rcsb pdb:5CBY|rcsb pdb:5CBZ|rcsb pdb:5CC1|refseq:XP_016864886.1|refseq:XP_016864887.1|rcsb pdb:5EMC|rcsb pdb:5EMP|rcsb pdb:5EMQ|rcsb pdb:5G3J|rcsb pdb:5G5W|rcsb pdb:5NFP|rcsb pdb:5NFT|rcsb pdb:5UC3|rcsb pdb:5VA0|rcsb pdb:5VA7|rcsb pdb:6BQU|rcsb pdb:6CFN|rcsb pdb:6DXK|rcsb pdb:6EL6|rcsb pdb:6EL7|rcsb pdb:6EL9|rcsb pdb:6X6D|rcsb pdb:6X6E|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6YOS|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-8849473|reactome:R-HSA-8939902|reactome:R-HSA-9615017|reactome:R-HSA-9679191|dip:DIP-576N|uniprotkb:P04150(identity)|genbank_protein_gi:324021671(identity)|ddbj/embl/genbank:BC015610(identity)|entrezgene/locuslink:2908(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:4IOUe8VfG++O0M9uS6phAd8TBzw9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q6NSI4 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-8634209|ensembl:ENSP00000361628|uniprotkb:Q9H7W5|uniprotkb:Q6PHY5|uniprotkb:Q6PII9|intact:MINT-8162145|uniprotkb:Q9NWA6|uniprotkb:Q5JQS1|uniprotkb:Q4G0L7|uniprotkb:H7BY89|uniprotkb:Q5JRF9|uniprotkb:Q6PJU8 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:radx_human(display_long)|uniprotkb:RADX(gene name)|psi-mi:RADX(display_short)|uniprotkb:CXorf57(gene name synonym)|uniprotkb:RPA-related and RAD51-antagonist, X-chromosome(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000147231(gene)|ensembl:ENST00000372548(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005657"(replication fork)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR040893|refseq:NP_060485.4|refseq:NP_001171711.1|uniprotkb:Q6NSI4(identity)|entrezgene/locuslink:55086(identity)|genbank_protein_gi:193804923(identity)|ddbj/embl/genbank:BC070110(identity) psi-mi:"MI:0469"(intact) - comment:mint figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:pUlTaH5Wq19LDuJp7qGlWFpa0q09606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9BTY7 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2|uniprotkb:P0CB43(identity)|genbank_protein_gi:113420249(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q71U36 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q96GD4 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N|uniprotkb:Q96GD4(identity)|ddbj/embl/genbank:BC009751(identity)|entrezgene/locuslink:9212(identity)|genbank_protein_gi:378786658(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q16342 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-359462|uniprotkb:Q9UH12|uniprotkb:E9PCU7|uniprotkb:F5GYS7|ensembl:ENSP00000439467|uniprotkb:Q58HM9|uniprotkb:Q58HN0 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:pdcd2_human(display_long)|uniprotkb:PDCD2(gene name)|psi-mi:PDCD2(display_short)|uniprotkb:RP8(gene name synonym)|uniprotkb:ZMYND7(gene name synonym)|uniprotkb:Zinc finger protein Rp-8(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_002589.2|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|mint:Q16342|ensembl:ENSG00000071994(gene)|ensembl:ENST00000541970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|refseq:NP_001186392.1|refseq:NP_001186393.1|refseq:NP_001186391.1|refseq:NP_659005.1|dip:DIP-27594N|uniprotkb:Q16342(identity)|genbank_protein_gi:21735592(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:I44GXBUa4NByhkP4HQdnUgfkNCs9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:O95433 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9GZT9 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1174818|uniprotkb:Q8N3M8|uniprotkb:Q9BZS8|uniprotkb:Q9BZT0|ensembl:ENSP00000355601 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:egln1_human(display_long)|uniprotkb:EGLN1(gene name)|psi-mi:EGLN1(display_short)|uniprotkb:C1orf12(gene name synonym)|uniprotkb:PNAS-118(orf name)|uniprotkb:PNAS-137(orf name)|uniprotkb:Hypoxia-inducible factor prolyl hydroxylase 2(gene name synonym)|uniprotkb:Prolyl hydroxylase domain-containing protein 2(gene name synonym)|uniprotkb:SM-20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_071334.1|ensembl:ENSG00000135766(gene)|ensembl:ENST00000366641(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0031543"(peptidyl-proline dioxygenase activity)|go:"GO:0031545"(peptidyl-proline 4-dioxygenase activity)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071731"(response to nitric oxide)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|mint:Q9GZT9|rcsb pdb:2G19|rcsb pdb:2G1M|rcsb pdb:2HBT|rcsb pdb:2HBU|rcsb pdb:2Y33|rcsb pdb:2Y34|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:3OUH|rcsb pdb:3OUI|rcsb pdb:3OUJ|rcsb pdb:4BQW|rcsb pdb:4BQX|rcsb pdb:4BQY|rcsb pdb:4JZR|rcsb pdb:4KBZ|rcsb pdb:4UWD|rcsb pdb:5A3U|rcsb pdb:5L9B|rcsb pdb:5L9R|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:5LAT|rcsb pdb:5LB6|rcsb pdb:5LBB|rcsb pdb:5LBC|rcsb pdb:5LBE|rcsb pdb:5LBF|rcsb pdb:5OX5|rcsb pdb:5OX6|rcsb pdb:5V18|rcsb pdb:6NMQ|rcsb pdb:6QGV|rcsb pdb:6ST3|rcsb pdb:6YVT|rcsb pdb:6YVW|rcsb pdb:6YVX|rcsb pdb:6YVZ|rcsb pdb:6YW0|rcsb pdb:6YW1|rcsb pdb:6YW2|rcsb pdb:6YW3|rcsb pdb:6YW4|rcsb pdb:6ZBN|rcsb pdb:6ZBO|reactome:R-HSA-1234176|dip:DIP-37495N|uniprotkb:Q9GZT9(identity)|genbank_protein_gi:13489073(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:mQuU/7x78A4wIxQZxk2Pldj+94s9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q96EK5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-744150|uniprotkb:A8K5M8|uniprotkb:Q9BR89|uniprotkb:Q9ULE1|uniprotkb:Q9Y428|ensembl:ENSP00000354848 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:kbp_human(display_long)|uniprotkb:KIF1-binding protein(gene name synonym)|uniprotkb:Kinesin family binding protein(gene name synonym)|uniprotkb:KBP(gene name synonym)|uniprotkb:KIAA1279(gene name synonym)|uniprotkb:KIFBP(gene name)|psi-mi:KIFBP(display_short)|uniprotkb:KIF1BP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_056449.1|ensembl:ENSG00000198954(gene)|ensembl:ENST00000361983(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0007399"(nervous system development)|go:"GO:0019894"(kinesin binding)|go:"GO:0030154"(cell differentiation)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR022083|mint:Q96EK5|rcsb pdb:6ZPG|rcsb pdb:6ZPH|uniprotkb:Q96EK5(identity)|genbank_protein_gi:24308113(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:wiRR4tDx91/cAUb2ANX42T+vhyI9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q7L3B6 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2841876|uniprotkb:B1AL70|uniprotkb:Q9NX16|uniprotkb:Q9NWS3|ensembl:ENSP00000371278 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cd37l_human(display_long)|uniprotkb:CDC37L1(gene name)|psi-mi:CDC37L1(display_short)|uniprotkb:CDC37B(gene name synonym)|uniprotkb:HARC(gene name synonym)|uniprotkb:Hsp90-associating relative of Cdc37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_060383.2|ensembl:ENSG00000106993(gene)|ensembl:ENST00000381854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|interpro:IPR004918(Cdc37)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|reactome:R-HSA-114608|uniprotkb:Q7L3B6(identity)|genbank_protein_gi:66773038(identity)|ddbj/embl/genbank:BC014133(identity)|entrezgene/locuslink:55664(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:pcnxOK8hdHEjLn3U3rsf4fpXBvY9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q16543 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q8IV38 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9393876|uniprotkb:A4D124|uniprotkb:Q96BL3|uniprotkb:Q659G1|ensembl:ENSP00000303570 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:anky2_human(display_long)|uniprotkb:ANKMY2(gene name)|psi-mi:ANKMY2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_064715.1|ensembl:ENSG00000106524(gene)|ensembl:ENST00000306999(transcript)|go:"GO:0005929"(cilium)|go:"GO:0019899"(enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR020683|interpro:IPR036770|uniprotkb:Q8IV38(identity)|genbank_protein_gi:28461129(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:Fw1jLmLiX4rE+TuKDLF96LFmORo9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q8IVD9 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P33991 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N|uniprotkb:P33991(identity)|genbank_protein_gi:33469917(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q15185 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9UHD1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9Y2Z0 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q86SX1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9392873 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P50750 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|uniprotkb:P50750(identity)|ddbj/embl/genbank:BC001968(identity)|entrezgene/locuslink:1025(identity)|genbank_protein_gi:4502747(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P11802 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-295644|uniprotkb:O00576|uniprotkb:Q6FG61|uniprotkb:B4DNF9|uniprotkb:B2R9A0|ensembl:ENSP00000257904 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cdk4_human(display_long)|uniprotkb:CDK4(gene name)|psi-mi:CDK4(display_short)|uniprotkb:Cell division protein kinase 4(gene name synonym)|uniprotkb:PSK-J3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_000066.1|dip:DIP-875N|ensembl:ENSG00000135446(gene)|ensembl:ENST00000257904(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060260"(regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060612"(adipose tissue development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097129"(cyclin D2-CDK4 complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904628"(cellular response to phorbol 13-acetate 12-myristate)|go:"GO:1904637"(cellular response to ionomycin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11802|rcsb pdb:1LD2|rcsb pdb:2W96|rcsb pdb:2W99|rcsb pdb:2W9F|rcsb pdb:2W9Z|rcsb pdb:3G33|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:6P8G|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-2559580|rcsb pdb:6P8E|rcsb pdb:6P8F|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-69231|reactome:R-HSA-75815|reactome:R-HSA-8849470|reactome:R-HSA-8878166|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|reactome:R-HSA-9661069|uniprotkb:P11802(identity)|genbank_protein_gi:4502735(identity)|ddbj/embl/genbank:BC003644(identity)|entrezgene/locuslink:1019(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:pxIzF9EkX+gMz7zj/TDiytYtsOc9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9H9A6 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1043135|uniprotkb:Q9NXC1|uniprotkb:Q9BTR7|uniprotkb:Q9NSK1|ensembl:ENSP00000359990 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:lrc40_human(display_long)|uniprotkb:LRRC40(gene name)|psi-mi:LRRC40(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000066557(gene)|ensembl:ENST00000370952(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_060238.3|uniprotkb:Q9H9A6(identity)|ddbj/embl/genbank:BC008586(identity)|entrezgene/locuslink:55631(identity)|genbank_protein_gi:21361633(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:DxDqTX9DvC1eU/vjACu8pZLo+Qk9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P10398 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N|uniprotkb:P10398(identity)|genbank_protein_gi:371875793(identity)|ddbj/embl/genbank:BC007514(identity)|entrezgene/locuslink:369(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9Y266 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P06737 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-2511865|ensembl:ENSP00000216392|uniprotkb:O60567|uniprotkb:O60913|uniprotkb:O60752|uniprotkb:A6NDQ4|uniprotkb:Q501V9|uniprotkb:Q96G82|uniprotkb:Q641R5|uniprotkb:B4DUB7|uniprotkb:F5H816 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:pygl_human(display_long)|uniprotkb:PYGL(gene name)|psi-mi:PYGL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000100504(gene)|ensembl:ENST00000216392(transcript)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0008184"(glycogen phosphorylase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0016208"(AMP binding)|go:"GO:0019842"(vitamin binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032052"(bile acid binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070266"(necroptotic process)|go:"GO:0102250"(linear malto-oligosaccharide phosphorylase activity)|go:"GO:0102499"(SHG alpha-glucan phosphorylase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000811(Glycosyl transferase, family 35)|interpro:IPR011833(Glycogen/starch/alpha-glucan phosphorylase)|interpro:IPR035090|mint:P06737|rcsb pdb:1EM6|rcsb pdb:1EXV|rcsb pdb:1FA9|rcsb pdb:1FC0|rcsb pdb:1L5Q|rcsb pdb:1L5R|rcsb pdb:1L5S|rcsb pdb:1L7X|rcsb pdb:1XOI|rcsb pdb:2ATI|rcsb pdb:2QLL|rcsb pdb:2ZB2|rcsb pdb:3CEH|rcsb pdb:3CEJ|rcsb pdb:3CEM|rcsb pdb:3DD1|rcsb pdb:3DDS|rcsb pdb:3DDW|reactome:R-HSA-70221|reactome:R-HSA-6798695|refseq:NP_001157412.1|refseq:NP_002854.3|uniprotkb:P06737(identity)|genbank_protein_gi:255653002(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:8h3TR7UB7SC/CFh5TXcjHvE/C709606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9BTE3 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q96AD5 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-716499|uniprotkb:O60643|uniprotkb:Q5EFF5|uniprotkb:Q6XYE5|uniprotkb:Q96ET6|uniprotkb:Q9NQ61|uniprotkb:Q9NQ62|ensembl:ENSP00000337701 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:plpl2_human(display_long)|uniprotkb:Adipose triglyceride lipase(gene name synonym)|uniprotkb:Desnutrin(gene name synonym)|uniprotkb:Transport-secretion protein 2(gene name synonym)|uniprotkb:TTS2.2(gene name synonym)|uniprotkb:Calcium-independent phospholipase A2(gene name synonym)|uniprotkb:IPLA2-zeta(gene name synonym)|uniprotkb:Pigment epithelium-derived factor(gene name synonym)|uniprotkb:PNPLA2(gene name)|psi-mi:PNPLA2(display_short)|uniprotkb:ATGL(gene name synonym)|uniprotkb:FP17548(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_065109.1|ensembl:ENSG00000177666(gene)|ensembl:ENST00000336615(transcript)|go:"GO:0004465"(lipoprotein lipase activity)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016411"(acylglycerol O-acyltransferase activity)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0036155"(acylglycerol acyl-chain remodeling)|go:"GO:0050253"(retinyl-palmitate esterase activity)|go:"GO:0055088"(lipid homeostasis)|interpro:IPR002641(Patatin)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR033562|interpro:IPR033903|reactome:R-HSA-1482883|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016873517.1|uniprotkb:Q96AD5(identity)|genbank_protein_gi:32698724(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:g8D6liiW4erXTIYpnxA6hDd4Md49606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:O15111 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-81249|uniprotkb:O14666|uniprotkb:Q13132|uniprotkb:Q5W0I4|uniprotkb:Q92467|ensembl:ENSP00000359424|intact:EBI-28970970 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ikka_human(display_long)|uniprotkb:CHUK(gene name)|psi-mi:CHUK(display_short)|uniprotkb:IKKA(gene name synonym)|uniprotkb:TCF16(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)|uniprotkb:Transcription factor 16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001269.3|ensembl:ENSP00000359424|ensembl:ENSG00000213341(gene)|ensembl:ENST00000370397(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0010034"(response to acetate)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022007|interpro:IPR041185|mint:O15111|rcsb pdb:3BRT|rcsb pdb:5EBZ|rcsb pdb:5TQW|rcsb pdb:5TQX|rcsb pdb:5TQY|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-198323|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5674400|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|dip:DIP-27526N|uniprotkb:O15111(identity)|entrezgene/locuslink:1147(identity)|ddbj/embl/genbank:BC092514(identity)|genbank_protein_gi:62241001(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:FVB/gXjSBTB9hdq9pycQogxesms9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9UQ88 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-373024|uniprotkb:O95227|uniprotkb:O95228|uniprotkb:O96012|uniprotkb:Q12821|uniprotkb:Q12853|uniprotkb:Q12854|uniprotkb:Q5QPR0|uniprotkb:Q5QPR1|uniprotkb:Q5QPR2|uniprotkb:Q9UBC4|uniprotkb:Q9UBI3|uniprotkb:Q9UEI1|uniprotkb:Q9UEI2|uniprotkb:Q9UP53|uniprotkb:Q9UP54|uniprotkb:Q9UP55|uniprotkb:Q9UP56|uniprotkb:Q9UQ86|uniprotkb:Q9UQ87|uniprotkb:Q9UQ89|uniprotkb:Q2TAJ0|ensembl:ENSP00000367900 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cd11a_human(display_long)|uniprotkb:CDK11A(gene name)|psi-mi:CDK11A(display_short)|uniprotkb:PITSLREB(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 2(gene name synonym)|uniprotkb:Galactosyltransferase-associated protein kinase p58/GTA(gene name synonym)|uniprotkb:CDC2L2(gene name synonym)|uniprotkb:CDC2L3(gene name synonym)|uniprotkb:PITSLRE serine/threonine-protein kinase CDC2L2(gene name synonym)|uniprotkb:Cell division protein kinase 11A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_076916.2|refseq:NP_277071.2|refseq:NP_001300825.1|refseq:NP_001300911.1|ensembl:ENSG00000008128(gene)|ensembl:ENST00000378633(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|mint:Q9UQ88|reactome:R-HSA-380270|uniprotkb:Q9UQ88(identity)|genbank_protein_gi:148763345(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:h30ee1oqCuzFkWhpX9dsmJFl9Y09606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:P08238 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:K9JA46 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-9392866 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:O95801 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q86SX3 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-3247115|ensembl:ENSP00000376308|uniprotkb:Q86TT5|uniprotkb:Q9H7H4|uniprotkb:Q86TT3|uniprotkb:Q96B41|uniprotkb:B5MDG3|uniprotkb:Q86TT4|uniprotkb:E9PAQ4 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:tedc1_human(display_long)|uniprotkb:TEDC1(gene name)|psi-mi:TEDC1(display_short)|uniprotkb:C14orf80(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001128347.1|ensembl:ENSG00000185347(gene)|ensembl:ENST00000392523(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|interpro:IPR028100|interpro:IPR043535|interpro:IPR027996|refseq:NP_001128348.1|refseq:NP_001185912.1|refseq:NP_001128349.1|dip:DIP-62062N|uniprotkb:Q86SX3(identity)|genbank_protein_gi:199560355(identity) psi-mi:"MI:0469"(intact) - crc64:3E34FACE82E0EACF figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:TEv3WjggyWs0uRE4CRaeSB7Wmfk9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q13418 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-747644|uniprotkb:P57043|uniprotkb:Q68DZ3|uniprotkb:B7Z1I0|uniprotkb:D3DQU0|uniprotkb:B7Z418|ensembl:ENSP00000299421|ensembl:ENSP00000379975|ensembl:ENSP00000403487 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:ilk_human(display_long)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:ILK(gene name)|psi-mi:ILK(display_short)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001265370.1|refseq:NP_001014794.1|refseq:NP_001014795.1|refseq:NP_004508.1|refseq:XP_005252961.1|refseq:NP_001265371.1|refseq:XP_005252962.1|refseq:XP_011518367.1|dip:DIP-38657N|rcsb pdb:3IXE|rcsb pdb:3KMU|rcsb pdb:3KMW|rcsb pdb:3REP|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIB|reactome:R-HSA-446343|reactome:R-HSA-446353|ensembl:ENSG00000166333(gene)|ensembl:ENST00000299421(transcript)|ensembl:ENST00000396751(transcript)|ensembl:ENST00000420936(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:Q13418|rcsb pdb:2KBX|rcsb pdb:3F6Q|go:"GO:0045663"(positive regulation of myoblast differentiation)|uniprotkb:Q13418(identity)|ddbj/embl/genbank:BC001554(identity)|genbank_protein_gi:4758606(identity)|entrezgene/locuslink:3611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:FrK/MsW7IcVWT9VbkHAIVHEh1P89606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9HB71 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q9Y6K9 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-81279|intact:EBI-356130|uniprotkb:Q7LBY6|uniprotkb:Q7Z7F1|ensembl:ENSP00000471166|ensembl:ENSP00000479662 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:nemo_human(display_long)|uniprotkb:IKBKG(gene name)|psi-mi:IKBKG(display_short)|uniprotkb:FIP3(gene name synonym)|uniprotkb:NEMO(gene name synonym)|uniprotkb:NF-kappa-B essential modifier(gene name synonym)|uniprotkb:Inhibitor of nuclear factor kappa-B kinase subunit gamma(gene name synonym)|uniprotkb:IkB kinase-associated protein 1(gene name synonym)|uniprotkb:FIP-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_001308325.1|refseq:NP_001308326.1|refseq:NP_001093326.2|refseq:NP_001093327.1|refseq:NP_001138727.1|refseq:NP_003630.1|dip:DIP-27528N|ensembl:ENSG00000269335(gene)|ensembl:ENST00000594239(transcript)|ensembl:ENST00000611071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990450"(linear polyubiquitin binding)|go:"GO:1990459"(transferrin receptor binding)|interpro:IPR021063|interpro:IPR032419|interpro:IPR034735|mint:Q9Y6K9|rcsb pdb:2JVX|rcsb pdb:2JVY|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:3CL3|rcsb pdb:3FX0|rcsb pdb:4BWN|rcsb pdb:5AAY|rcsb pdb:5LDE|rcsb pdb:6MI3|rcsb pdb:6MI4|rcsb pdb:6YEK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-4755510|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|uniprotkb:Q9Y6K9(identity)|genbank_protein_gi:153792133(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:9OeZIMeJvNtDEMoiLaKwVEpxSSM9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:O75190 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13451 uniprotkb:Q92990 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 intact:EBI-726150|uniprotkb:Q9BVE8|uniprotkb:Q5VVC3|ensembl:ENSP00000359385 psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:glmn_human(display_long)|uniprotkb:FAP68(gene name synonym)|uniprotkb:FKBP-associated protein(gene name synonym)|uniprotkb:FK506-binding protein-associated protein(gene name synonym)|uniprotkb:GLMN(gene name)|psi-mi:GLMN(display_short)|uniprotkb:FAP48(gene name synonym)|uniprotkb:VMGLOM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9393873|imex:IM-22301-1581 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) refseq:NP_444504.1|refseq:XP_011538848.1|refseq:NP_001306612.1|ensembl:ENSG00000174842(gene)|ensembl:ENST00000370360(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005171"(hepatocyte growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0055105"(ubiquitin-protein transferase inhibitor activity)|interpro:IPR013877(Protein of unknown function DUF1760, fungi)|interpro:IPR019516|rcsb pdb:4F52|reactome:R-HSA-983168|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|uniprotkb:Q92990(identity)|genbank_protein_gi:16933537(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 rogid:ZpLZbiPwlYDPX8C767kVrbKmEmo9606 intact-crc:CEC4B2A9037B4AD5|rigid:W5C8Gq+ui5xRnOwqLRvgmY6uUeo false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:P08238 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:O94966 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:Q15185 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:Q16543 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:Q9UHV9 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity)|genbank_protein_gi:12408675(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:P61758 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1|uniprotkb:P61758(identity)|entrezgene/locuslink:7411(identity)|genbank_protein_gi:4507873(identity)|ddbj/embl/genbank:BC046094(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:K9JA46 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-9392866 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:P22059 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-2681902|uniprotkb:Q6P524|ensembl:ENSP00000263847 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:osbp1_human(display_long)|uniprotkb:OSBP1(gene name synonym)|uniprotkb:OSBP(gene name)|psi-mi:OSBP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) refseq:NP_002547.1|ensembl:ENSG00000110048(gene)|ensembl:ENST00000263847(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015918"(sterol transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0120015"(sterol transfer activity)|go:"GO:1904411"(positive regulation of secretory granule organization)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|rcsb pdb:2RR3|reactome:R-HSA-1660661|reactome:R-HSA-192105|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|uniprotkb:P22059(identity)|entrezgene/locuslink:5007(identity)|genbank_protein_gi:4505531(identity)|ddbj/embl/genbank:BC011581(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:9LgzhfWQ0E/ECTTKA1OogQSyuAI9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75344 uniprotkb:Q86SX1 intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4 intact:EBI-9392873 psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394076|imex:IM-22301-1582 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1|uniprotkb:O75344(identity)|ddbj/embl/genbank:BC036817(identity)|entrezgene/locuslink:8468(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:B0677CF6894997A6|rigid:m2YOBBWBPlLfvt0Zg4c+urjnTg4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14318 uniprotkb:Q13371 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-5772890|uniprotkb:Q96AF1|uniprotkb:Q9UEW7|uniprotkb:Q9UFL0|uniprotkb:Q9UNX1|uniprotkb:Q9UNX2|uniprotkb:Q4VXB6|ensembl:ENSP00000259467 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:phlp_human(display_long)|uniprotkb:PDCL(gene name)|psi-mi:PDCL(display_short)|uniprotkb:PHLOP1(gene name synonym)|uniprotkb:PhLP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394135|imex:IM-22301-1583 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|ddbj/embl/genbank:BC009966(identity) refseq:NP_005379.3|ensembl:ENSG00000136940(gene)|ensembl:ENST00000259467(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0030030"(cell projection organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:1902605"(heterotrimeric G-protein complex assembly)|interpro:IPR001200(Phosducin)|interpro:IPR023196|interpro:IPR024253|interpro:IPR036249|mint:Q13371|reactome:R-HSA-6814122|uniprotkb:Q13371(identity)|genbank_protein_gi:88758594(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:9XcDuIplR06JuJG4RXH3L6Uy7Xo9606 intact-crc:C95C5F9519BC1508|rigid:XR17LTIC9aPOT8Hi/i7XcF51GFs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14318 uniprotkb:Q9HB71 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394135|imex:IM-22301-1583 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|ddbj/embl/genbank:BC009966(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:C95C5F9519BC1508|rigid:XR17LTIC9aPOT8Hi/i7XcF51GFs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14318 uniprotkb:Q9NZL4 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-356763|uniprotkb:O95351|uniprotkb:Q6ZNU5|uniprotkb:B3KQP0|uniprotkb:B4DG11|ensembl:ENSP00000255631|ensembl:ENSP00000398244|ensembl:ENSP00000467574 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:hpbp1_human(display_long)|uniprotkb:HSPBP1(gene name)|psi-mi:HSPBP1(display_short)|uniprotkb:HSPBP(gene name synonym)|uniprotkb:PP1845(orf name)|uniprotkb:Heat shock protein-binding protein 1(gene name synonym)|uniprotkb:Hsp70-interacting protein 1(gene name synonym)|uniprotkb:Hsp70-binding protein 2(gene name synonym)|uniprotkb:Hsp70-interacting protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394135|imex:IM-22301-1583 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|ddbj/embl/genbank:BC009966(identity) refseq:NP_001123578.1|refseq:NP_036399.3|ensembl:ENSG00000133265(gene)|ensembl:ENST00000255631(transcript)|ensembl:ENST00000433386(transcript)|ensembl:ENST00000587922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013918(Nucleotide exchange factor Fes1)|interpro:IPR016024(Armadillo-type fold)|mint:Q9NZL4|rcsb pdb:1XQR|rcsb pdb:1XQS|refseq:NP_001284529.1|refseq:XP_016882033.1|uniprotkb:Q9NZL4(identity)|genbank_protein_gi:112363070(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:26Au2GesO5ysT/yhYX/0oOO9Md89606 intact-crc:C95C5F9519BC1508|rigid:XR17LTIC9aPOT8Hi/i7XcF51GFs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14318 uniprotkb:Q9Y2Z0 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394135|imex:IM-22301-1583 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|ddbj/embl/genbank:BC009966(identity) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:C95C5F9519BC1508|rigid:XR17LTIC9aPOT8Hi/i7XcF51GFs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14318 uniprotkb:Q15185 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394135|imex:IM-22301-1583 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N|uniprotkb:Q14318(identity)|entrezgene/locuslink:23770(identity)|ddbj/embl/genbank:BC009966(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:C95C5F9519BC1508|rigid:XR17LTIC9aPOT8Hi/i7XcF51GFs false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:Q86SX1 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9392873 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:Q9BW92 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-1045099|uniprotkb:Q53GW7|uniprotkb:Q96I50|ensembl:ENSP00000358060|uniprotkb:Q9H9V2 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:sytm_human(display_long)|uniprotkb:Threonyl-tRNA synthetase-like 1(gene name synonym)|uniprotkb:TARS2(gene name)|psi-mi:TARS2(display_short)|uniprotkb:TARSL1(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) refseq:NP_079426.2|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|reactome:R-HSA-379726|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|ensembl:ENSG00000143374(gene)|ensembl:ENST00000369064(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070159"(mitochondrial threonyl-tRNA aminoacylation)|refseq:NP_001258825.1|uniprotkb:Q9BW92(identity)|genbank_protein_gi:20070344(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:9osvUit1PmESv7edUxgA1cl3o/Y9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:P08238 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:Q16543 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:P68363 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328|uniprotkb:P68363(identity)|genbank_protein_gi:57013276(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:Q8WVL7 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9381820|uniprotkb:Q9NXK7|uniprotkb:Q8NDF2|uniprotkb:Q96JE5|ensembl:ENSP00000303518|ensembl:ENSP00000440396 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:anr49_human(display_long)|uniprotkb:ANKRD49(gene name)|psi-mi:ANKRD49(display_short)|uniprotkb:FGIF(gene name synonym)|uniprotkb:Fetal globin-inducing factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) refseq:XP_016873430.1|refseq:NP_060174.2|dip:DIP-61280N|ensembl:ENSG00000168876(gene)|ensembl:ENST00000302755(transcript)|ensembl:ENST00000544612(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|uniprotkb:Q8WVL7(identity)|genbank_protein_gi:41350198(identity)|entrezgene/locuslink:54851(identity)|ddbj/embl/genbank:BC017798(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:CqaXSfdo5/Rgwa/Zm6bKu5CAv8g9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:O94966 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:O95433 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UIM3 uniprotkb:K9JA46 intact:EBI-719882|uniprotkb:A8K5V3|uniprotkb:B0UYX8|uniprotkb:Q9H5G3|ensembl:ENSP00000364298|ensembl:ENSP00000397530|ensembl:ENSP00000398812|ensembl:ENSP00000412439 intact:EBI-9392866 psi-mi:fkbpl_human(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:FKBPL(gene name)|psi-mi:FKBPL(display_short)|uniprotkb:DIR1(gene name synonym)|uniprotkb:NG7(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394167|imex:IM-22301-1584 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071393.2|ensembl:ENSG00000204315(gene)|ensembl:ENSG00000223666(gene)|ensembl:ENSG00000224200(gene)|ensembl:ENSG00000230907(gene)|ensembl:ENST00000375156(transcript)|ensembl:ENST00000425378(transcript)|ensembl:ENST00000443350(transcript)|ensembl:ENST00000456854(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0009314"(response to radiation)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-HSA-8852276|uniprotkb:Q9UIM3(identity)|genbank_protein_gi:17149853(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:1tnbTRtrXPNdsAQspjZ+hNW3zXg9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:EE07F796BC2DBE7A|rigid:SSjif+FIlUpn35GK7Y+U2ZhWbkk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:O00505 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276|uniprotkb:O00505(identity)|genbank_protein_gi:34485722(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:O95817 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:O95757 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-358652|uniprotkb:Q4W5M5|uniprotkb:Q8IWA2|uniprotkb:A2ICT2|ensembl:ENSP00000296464|ensembl:ENSP00000422482 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:hs74l_human(display_long)|uniprotkb:HSPA4L(gene name)|psi-mi:HSPA4L(display_short)|uniprotkb:APG1(gene name synonym)|uniprotkb:OSP94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)|uniprotkb:Heat-shock protein family A member 4-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:O95757|reactome:R-HSA-3371453|refseq:NP_055093.2|refseq:NP_001304310.1|refseq:NP_001304311.1|refseq:NP_001304312.1|go:"GO:0005634"(nucleus)|ensembl:ENSG00000164070(gene)|ensembl:ENST00000296464(transcript)|ensembl:ENST00000508776(transcript)|go:"GO:0005524"(ATP binding)|uniprotkb:O95757(identity)|genbank_protein_gi:31541941(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:6ZoMlI4t4A4u4YsQgrlcwAqjpi49606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:Q9NZL4 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-356763|uniprotkb:O95351|uniprotkb:Q6ZNU5|uniprotkb:B3KQP0|uniprotkb:B4DG11|ensembl:ENSP00000255631|ensembl:ENSP00000398244|ensembl:ENSP00000467574 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:hpbp1_human(display_long)|uniprotkb:HSPBP1(gene name)|psi-mi:HSPBP1(display_short)|uniprotkb:HSPBP(gene name synonym)|uniprotkb:PP1845(orf name)|uniprotkb:Heat shock protein-binding protein 1(gene name synonym)|uniprotkb:Hsp70-interacting protein 1(gene name synonym)|uniprotkb:Hsp70-binding protein 2(gene name synonym)|uniprotkb:Hsp70-interacting protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001123578.1|refseq:NP_036399.3|ensembl:ENSG00000133265(gene)|ensembl:ENST00000255631(transcript)|ensembl:ENST00000433386(transcript)|ensembl:ENST00000587922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013918(Nucleotide exchange factor Fes1)|interpro:IPR016024(Armadillo-type fold)|mint:Q9NZL4|rcsb pdb:1XQR|rcsb pdb:1XQS|refseq:NP_001284529.1|refseq:XP_016882033.1|uniprotkb:Q9NZL4(identity)|genbank_protein_gi:112363070(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:26Au2GesO5ysT/yhYX/0oOO9Md89606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:Q03933 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity)|genbank_protein_gi:207113147(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:P22392 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-713693|ensembl:ENSP00000376886|ensembl:ENSP00000421064|ensembl:ENSP00000425581|ensembl:ENSP00000426901|ensembl:ENSP00000426976|uniprotkb:A8MWA3|uniprotkb:Q1WM23|uniprotkb:Q6LCT6 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:ndkb_human(display_long)|uniprotkb:nm23-H2(gene name synonym)|uniprotkb:C-myc purine-binding transcription factor PUF(gene name synonym)|uniprotkb:NME2(gene name)|psi-mi:NME2(display_short)|uniprotkb:NM23B(gene name synonym)|uniprotkb:Histidine protein kinase NDKB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) ensembl:ENSG00000243678(gene)|ensembl:ENST00000393190(transcript)|ensembl:ENST00000503064(transcript)|ensembl:ENST00000512737(transcript)|ensembl:ENST00000513177(transcript)|ensembl:ENST00000514264(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_001018146.1|refseq:NP_001018147.1|refseq:NP_001018148.1|refseq:NP_001018149.1|refseq:NP_002503.1|dip:DIP-50179N|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:P22392|rcsb pdb:1NSK|rcsb pdb:1NUE|rcsb pdb:3BBB|rcsb pdb:3BBC|rcsb pdb:3BBF|reactome:R-HSA-499943|reactome:R-HSA-6798695|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|uniprotkb:P22392(identity)|genbank_protein_gi:310923127(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:GHHfoXOuc25KIJJqiW9r+OWm5Kk9606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:P04792 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|genbank_protein_gi:4504517(identity)|ddbj/embl/genbank:BC012292(identity)|entrezgene/locuslink:3315(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q00613 uniprotkb:O00629 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 intact:EBI-396343|uniprotkb:O00190|intact:EBI-28976443|ensembl:ENSP00000334373|uniprotkb:A8K4S6|uniprotkb:D3DNM2 psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:ima3_human(display_long)|uniprotkb:KPNA4(gene name)|psi-mi:KPNA4(display_short)|uniprotkb:QIP1(gene name synonym)|uniprotkb:Karyopherin subunit alpha-4(gene name synonym)|uniprotkb:Importin alpha Q1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394221|imex:IM-22301-1585 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity)|ddbj/embl/genbank:BC014638(identity) refseq:NP_002259.1|ensembl:ENSG00000186432(gene)|ensembl:ENST00000334256(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00629|rcsb pdb:4UAE|rcsb pdb:5TBK|rcsb pdb:5XZX|rcsb pdb:6BVV|rcsb pdb:6BVZ|rcsb pdb:6BW9|rcsb pdb:6BWA|rcsb pdb:6BWB|rcsb pdb:6WX8|rcsb pdb:7JJL|reactome:R-HSA-1169408|reactome:R-HSA-168276|ensembl:ENSP00000334373|dip:DIP-32982N|uniprotkb:O00629(identity)|genbank_protein_gi:4504901(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 rogid:/cng/xZ42E2juzHNOpuQTP+amx89606 intact-crc:76559504F961C445|rigid:Jjuzshp1njoBzhYW7N7GJNcS+Gk false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q03933 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-2556750|uniprotkb:B4DGJ4|uniprotkb:Q0VAH9|uniprotkb:Q9H445|uniprotkb:Q2M1K4|intact:EBI-28983899|ensembl:ENSP00000357440 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:hsf2_human(display_long)|uniprotkb:HSTF2(gene name synonym)|uniprotkb:Heat shock transcription factor 2(gene name synonym)|uniprotkb:HSF2(gene name)|psi-mi:HSF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:NP_001129036.1|refseq:NP_004497.1|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027712|interpro:IPR027725|interpro:IPR036390|interpro:IPR036388|rcsb pdb:5D8K|rcsb pdb:5D8L|rcsb pdb:5HDK|ensembl:ENSG00000025156(gene)|ensembl:ENST00000368455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSP00000357440|ensembl:ENST00000452194|ensembl:ENSP00000400380|dip:DIP-56593N|uniprotkb:Q03933(identity)|genbank_protein_gi:207113147(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:AdzFV3b/EVFGdLy9HlQYlnYwjbQ9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q9UKN7 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-715302|uniprotkb:B4DFC7|intact:EBI-28973079|ensembl:ENSP00000495481 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:myo15_human(display_long)|uniprotkb:Unconventional myosin-15(gene name synonym)|uniprotkb:MYO15A(gene name)|psi-mi:MYO15A(display_short)|uniprotkb:MYO15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:NP_057323.3|ensembl:ENST00000418233|ensembl:ENSP00000408800|ensembl:ENSP00000495481|ensembl:ENSG00000091536(gene)|ensembl:ENST00000647165(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098858"(actin-based cell projection)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001452(Src homology-3)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR035487|interpro:IPR035963|interpro:IPR036028|interpro:IPR036057|interpro:IPR036961|interpro:IPR038185|interpro:IPR041795|rcsb pdb:6KZ1|reactome:R-HSA-9662360|reactome:R-HSA-9662361|uniprotkb:Q9UKN7(identity)|genbank_protein_gi:118402590(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:MWwfRkw2a7EVQGyy1+0qEzTVdEA9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q9Y5L4 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020|uniprotkb:Q9Y5L4(identity)|genbank_protein_gi:11024700(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q15276 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|uniprotkb:Q15276(identity)|genbank_protein_gi:134152674(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q86VW0 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-6117072|uniprotkb:Q53R38|uniprotkb:Q53SP3|uniprotkb:Q5GM69|uniprotkb:Q8N6M1|uniprotkb:Q96LQ2|ensembl:ENSP00000415332 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:sesd1_human(display_long)|uniprotkb:SESTD1(gene name)|psi-mi:SESTD1(display_short)|uniprotkb:SOLO(gene name synonym)|uniprotkb:Huntingtin-interacting protein-like protein(gene name synonym)|uniprotkb:Protein Solo(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:XP_011510441.1|refseq:NP_835224.3|ensembl:ENSG00000187231(gene)|ensembl:ENST00000428443(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|uniprotkb:Q86VW0(identity)|genbank_protein_gi:188528641(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:GS9Hqrsyep/iL7L8gQwOJhX95IY9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q13395 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-2515586|ensembl:ENSP00000040877|uniprotkb:Q9H581 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:tarb1_human(display_long)|uniprotkb:TARBP1(gene name)|psi-mi:TARBP1(display_short)|uniprotkb:TRM3(gene name synonym)|uniprotkb:TRP185(gene name synonym)|uniprotkb:TAR RNA-binding protein 1(gene name synonym)|uniprotkb:TAR RNA-binding protein of 185 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) ensembl:ENSG00000059588(gene)|ensembl:ENST00000040877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016423"("tRNA (guanine) methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025806|interpro:IPR029026|interpro:IPR029028|interpro:IPR044748|rcsb pdb:2HA8|refseq:NP_005637.3|uniprotkb:Q13395(identity)|genbank_protein_gi:110825988(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:nTo6BVWftdY8LcSh7gDoWtCURK89606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q13451 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q00613 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-719620|uniprotkb:A8MW26|uniprotkb:Q53XT4|uniprotkb:A8K4L0|ensembl:ENSP00000431512|ensembl:ENSP00000493830 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:hsf1_human(display_long)|uniprotkb:Heat shock transcription factor 1(gene name synonym)|uniprotkb:HSF1(gene name)|psi-mi:HSF1(display_short)|uniprotkb:HSTF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) refseq:NP_005517.1|go:"GO:0006397"(mRNA processing)|go:"GO:0006952"(defense response)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009299"(mRNA transcription)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014823"(response to activity)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033574"(response to testosterone)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034622"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061408"(positive regulation of transcription from RNA polymerase II promoter in response to heat stress)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0097165"(nuclear stress granule)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|go:"GO:0101031"(chaperone complex)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902512"(positive regulation of apoptotic DNA fragmentation)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904843"(cellular response to nitroglycerin)|go:"GO:1904845"(cellular response to L-glutamine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990910"(response to hypobaric hypoxia)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR010542(Vertebrate heat shock transcription factor)|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|mint:Q00613|rcsb pdb:2LDU|rcsb pdb:5D5U|rcsb pdb:5D5V|rcsb pdb:5HDG|rcsb pdb:5HDN|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-9646399|ensembl:ENSG00000185122(gene)|ensembl:ENSG00000284774(gene)|ensembl:ENST00000528838(transcript)|ensembl:ENST00000646252(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|refseq:XP_016868866.1|dip:DIP-35670N|ddbj/embl/genbank:BC014638(identity)|uniprotkb:Q00613(identity)|entrezgene/locuslink:3297(identity)|genbank_protein_gi:5031767(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:8Kc0CyLMImN2fpNco/AAIbJk+6k9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9ULV5 uniprotkb:Q9Y2Z0 intact:EBI-766428|uniprotkb:Q99472|uniprotkb:Q9ULV6|ensembl:ENSP00000430947 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:hsf4_human(display_long)|uniprotkb:Heat shock transcription factor 4(gene name synonym)|uniprotkb:HSF4(gene name)|psi-mi:HSF4(display_short) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394268|imex:IM-22301-1586 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035757.1|refseq:NP_001529.2|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007601"(visual perception)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048468"(cell development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:6J6V|rcsb pdb:6J6W|ensembl:ENSG00000102878(gene)|ensembl:ENST00000521374(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|uniprotkb:Q9ULV5(identity) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:a93s7Ye3QI/91xU1vhBEOH9p4rU9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:C500F9A4F4AB8588|rigid:JUCo7qj0tqmAbrFah+Vjo4XzOJA false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4G112 uniprotkb:P12814 intact:EBI-9394318|uniprotkb:Q08EH7|uniprotkb:Q8N7V2|ensembl:ENSP00000313243 intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403 psi-mi:hsf5_human(display_long)|uniprotkb:HSF5(gene name)|psi-mi:HSF5(display_short)|uniprotkb:HSTF5(gene name synonym)|uniprotkb:Heat shock transcription factor 5(gene name synonym) psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394315|imex:IM-22301-1587 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001073908.2|ensembl:ENSG00000176160(gene)|ensembl:ENST00000323777(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027736|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q4G112(identity) refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034|uniprotkb:P12814(identity)|genbank_protein_gi:194097350(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:2GsH/J+HS+ZaWbdrXxBJeum7gt49606 rogid:guTURyt26f1ort4NAlYyabNc+WE9606 intact-crc:B27070383FABD443|rigid:6ljgfuVGsf3oYBN2eejU2d3t4/0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4G112 uniprotkb:Q9Y3Z3 intact:EBI-9394318|uniprotkb:Q08EH7|uniprotkb:Q8N7V2|ensembl:ENSP00000313243 intact:EBI-1054601|uniprotkb:Q5JXG8|uniprotkb:Q9H004|uniprotkb:Q9H005|uniprotkb:Q9H3U9|uniprotkb:B4E2A5|uniprotkb:Q8N491|uniprotkb:E1P5V2|ensembl:ENSP00000493536|ensembl:ENSP00000495667|ensembl:ENSP00000506877|ensembl:ENSP00000507178 psi-mi:hsf5_human(display_long)|uniprotkb:HSF5(gene name)|psi-mi:HSF5(display_short)|uniprotkb:HSTF5(gene name synonym)|uniprotkb:Heat shock transcription factor 5(gene name synonym) psi-mi:samh1_human(display_long)|uniprotkb:Dendritic cell-derived IFNG-induced protein(gene name synonym)|uniprotkb:Monocyte protein 5(gene name synonym)|uniprotkb:SAMHD1(gene name)|psi-mi:SAMHD1(display_short)|uniprotkb:MOP5(gene name synonym)|uniprotkb:SAM domain and HD domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394315|imex:IM-22301-1587 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001073908.2|ensembl:ENSG00000176160(gene)|ensembl:ENST00000323777(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027736|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q4G112(identity) refseq:NP_056289.2|refseq:XP_005260441.1|ensembl:ENSG00000101347(gene)|ensembl:ENST00000646673(transcript)|ensembl:ENST00000646869(transcript)|ensembl:ENST00000683766(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003676"(nucleic acid binding)|ensembl:ENST00000682773(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006203"(dGTP catabolic process)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008832"(dGTPase activity)|go:"GO:0009264"(deoxyribonucleotide catabolic process)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016793"(triphosphoric monoester hydrolase activity)|go:"GO:0032567"(dGTP binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046061"(dATP catabolic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:0106375"(deoxynucleoside triphosphate hydrolase activity)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013761(Sterile alpha motif-type)|mint:Q9Y3Z3|rcsb pdb:2E8O|rcsb pdb:3U1N|rcsb pdb:4BZB|rcsb pdb:4BZC|rcsb pdb:4CC9|rcsb pdb:4MZ7|rcsb pdb:4Q7H|rcsb pdb:4QFX|rcsb pdb:4QFY|rcsb pdb:4QFZ|rcsb pdb:4QG0|rcsb pdb:4QG1|rcsb pdb:4QG2|rcsb pdb:4QG4|rcsb pdb:4RXO|rcsb pdb:4RXP|rcsb pdb:4RXQ|rcsb pdb:4RXR|rcsb pdb:4RXS|rcsb pdb:4TNP|rcsb pdb:4TNQ|rcsb pdb:4TNR|rcsb pdb:4TNX|rcsb pdb:4TNY|rcsb pdb:4TNZ|rcsb pdb:4TO0|rcsb pdb:4TO1|rcsb pdb:4TO2|rcsb pdb:4TO3|rcsb pdb:4TO4|rcsb pdb:4TO5|rcsb pdb:6DW4|rcsb pdb:6DW5|rcsb pdb:6DW7|rcsb pdb:6DWD|rcsb pdb:6DWJ|rcsb pdb:6DWK|rcsb pdb:6TX0|rcsb pdb:6TXA|rcsb pdb:6TXC|rcsb pdb:6TXE|rcsb pdb:6TXF|rcsb pdb:6U6X|rcsb pdb:6U6Y|rcsb pdb:6U6Z|rcsb pdb:6XU1|rcsb pdb:6YOM|rcsb pdb:7A5Y|reactome:R-HSA-8956319|rcsb pdb:4TO6|rcsb pdb:4ZWE|reactome:R-HSA-909733|rcsb pdb:4ZWG|rcsb pdb:5AO0|rcsb pdb:5AO1|rcsb pdb:5AO2|rcsb pdb:5AO3|rcsb pdb:5AO4|rcsb pdb:6CM2|rcsb pdb:6DW3|dip:DIP-50704N|uniprotkb:Q9Y3Z3(identity)|genbank_protein_gi:38016914(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:2GsH/J+HS+ZaWbdrXxBJeum7gt49606 rogid:cxoMHFueO9JuBg2d0PoGCYoOwY09606 intact-crc:B27070383FABD443|rigid:6ljgfuVGsf3oYBN2eejU2d3t4/0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBD0 uniprotkb:P13611 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 intact:EBI-8515977|intact:MINT-4529155|uniprotkb:Q15123|uniprotkb:P20754|uniprotkb:Q9UNW5|uniprotkb:Q13189|uniprotkb:Q13010|uniprotkb:Q9UCL9|ensembl:ENSP00000265077 psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:cspg2_human(display_long)|uniprotkb:VCAN(gene name)|psi-mi:VCAN(display_short)|uniprotkb:CSPG2(gene name synonym)|uniprotkb:Large fibroblast proteoglycan(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan core protein 2(gene name synonym)|uniprotkb:PG-M(gene name synonym)|uniprotkb:Glial hyaluronate-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394337|imex:IM-22301-1588 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity) refseq:NP_001119808.1|refseq:NP_001157569.1|refseq:NP_001157570.1|refseq:NP_004376.2|ensembl:ENSG00000038427(gene)|ensembl:ENST00000265077(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0007155"(cell adhesion)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008037"(cell recognition)|go:"GO:0008347"(glial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030021"(extracellular matrix structural constituent conferring compression resistance)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033165"(interphotoreceptor matrix)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR000538(Link)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001304(C-type lectin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018097|interpro:IPR018378|interpro:IPR033987|interpro:IPR035976|interpro:IPR036179|mint:P13611|reactome:R-HSA-1971475|reactome:R-HSA-2022870|reactome:R-HSA-2022923|reactome:R-HSA-2024101|reactome:R-HSA-3000178|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3595172|reactome:R-HSA-3595174|reactome:R-HSA-3595177|reactome:R-HSA-381426|reactome:R-HSA-4420332|reactome:R-HSA-8957275|uniprotkb:P13611(identity)|genbank_protein_gi:21361116(identity) psi-mi:"MI:0469"(intact) - comment:mint|comment:homomint|function:May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid|function:"Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:143200]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN" figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 rogid:hnqTxboVu1BtuxYP2jENLXXZqcQ9606 intact-crc:1DC06ACE72AEFB1D|rigid:qrEO2DTb2V1nJJbaPAxpzV/0XiQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBD0 uniprotkb:Q9NSE4 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 intact:EBI-1054770|uniprotkb:B2RPG8|uniprotkb:Q1M2P9|uniprotkb:Q6PI85|uniprotkb:Q7L439|uniprotkb:Q86WU9|uniprotkb:Q96D91|uniprotkb:Q9H9Q8|uniprotkb:Q9NW42|ensembl:ENSP00000355889 psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:syim_human(display_long)|uniprotkb:IARS2(gene name)|psi-mi:IARS2(display_short)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394337|imex:IM-22301-1588 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity) refseq:NP_060530.3|ensembl:ENSG00000067704(gene)|ensembl:ENST00000366922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010663(DNA glycosylase/AP lyase and isoleucyl tRNA synthetase, zinc finger domain)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023585|interpro:IPR033708|mint:Q9NSE4|reactome:R-HSA-379726|uniprotkb:Q9NSE4(identity)|genbank_protein_gi:46852147(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 rogid:+3/hUjD0USVo2/G+Z9aOKpQKwhE9606 intact-crc:1DC06ACE72AEFB1D|rigid:qrEO2DTb2V1nJJbaPAxpzV/0XiQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBD0 uniprotkb:Q2TAC2 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 intact:EBI-2808286|ensembl:ENSP00000374292|uniprotkb:Q8IWG2|uniprotkb:A8MQC7|uniprotkb:Q8TER3|uniprotkb:A6NP51 psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:ccd57_human(display_long)|uniprotkb:CCDC57(gene name)|psi-mi:CCDC57(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394337|imex:IM-22301-1588 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity) ensembl:ENSG00000176155(gene)|ensembl:ENST00000389641(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007099"(centriole replication)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0060271"(cilium assembly)|interpro:IPR042481|refseq:NP_001303250.1|refseq:NP_932348.2|uniprotkb:Q2TAC2(identity)|entrezgene/locuslink:284001(identity)|genbank_protein_gi:92091575(identity)|ddbj/embl/genbank:BC040264(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 rogid:YDj66sk5KcrdUoP6zw9gIxHkomg9606 intact-crc:1DC06ACE72AEFB1D|rigid:qrEO2DTb2V1nJJbaPAxpzV/0XiQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBD0 uniprotkb:Q9GZU8 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 intact:EBI-2371956|ensembl:ENSP00000335808|ensembl:ENSP00000374098|ensembl:ENSP00000456211|ensembl:ENSP00000457740|ensembl:ENSP00000457850 psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:pip30_human(display_long)|uniprotkb:PSME3IP1(gene name)|psi-mi:PSME3IP1(display_short)|uniprotkb:C16orf94(gene name synonym)|uniprotkb:FAM192A(gene name synonym)|uniprotkb:NEFA-interacting nuclear protein NIP30(gene name synonym)|uniprotkb:NIP30(gene name synonym)|uniprotkb:PA28G-interacting protein(gene name synonym)|uniprotkb:PIP30(gene name synonym)|uniprotkb:CDA018(orf name)|uniprotkb:CDA10(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394337|imex:IM-22301-1588 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity) refseq:XP_011521645.1|refseq:NP_079222.1|refseq:XP_005256217.1|refseq:XP_005256220.1|refseq:XP_005256221.1|refseq:XP_005256222.1|refseq:XP_016879171.1|refseq:XP_016879172.1|refseq:XP_016879173.1|refseq:XP_016879174.1|refseq:XP_016879175.1|refseq:XP_016879176.1|refseq:XP_016879177.1|refseq:XP_016879178.1|refseq:XP_016879179.1|refseq:XP_016879180.1|refseq:XP_016879181.1|refseq:XP_016879182.1|refseq:XP_016879183.1|refseq:XP_016879184.1|refseq:XP_016879185.1|refseq:XP_016879186.1|refseq:XP_016879187.1|refseq:XP_016879188.1|refseq:XP_016879189.1|refseq:XP_016879190.1|refseq:XP_016879191.1|refseq:XP_016879192.1|refseq:XP_016879193.1|ensembl:ENSG00000172775(gene)|ensembl:ENST00000309137(transcript)|ensembl:ENST00000389447(transcript)|ensembl:ENST00000564108(transcript)|ensembl:ENST00000567439(transcript)|ensembl:ENST00000569266(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|interpro:IPR019331|interpro:IPR039845|mint:Q9GZU8|uniprotkb:Q9GZU8(identity)|genbank_protein_gi:13376429(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 rogid:L6twOcOqRARWRz4Em7oxxyLGsL09606 intact-crc:1DC06ACE72AEFB1D|rigid:qrEO2DTb2V1nJJbaPAxpzV/0XiQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UBD0 uniprotkb:Q9UBD0 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 intact:EBI-947253|ensembl:ENSP00000359444|ensembl:ENSP00000469223 psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:hsfx1_human(display_long)|uniprotkb:HSFX1(gene name)|psi-mi:HSFX1(display_short)|uniprotkb:LW-1(gene name synonym)|uniprotkb:HSFX2(gene name)|psi-mi:HSFX2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394337|imex:IM-22301-1588 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity) refseq:NP_001157887.1|refseq:NP_057237.1|ensembl:ENSG00000171116(gene)|ensembl:ENSG00000268738(gene)|ensembl:ENST00000370416(transcript)|ensembl:ENST00000598963(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR036388|interpro:IPR036390|uniprotkb:Q9UBD0(identity)|genbank_protein_gi:256542315(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2019/04/15 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 rogid:GGvrt/0TtcGSgEYevZhtq4pNd+E9606 intact-crc:1DC06ACE72AEFB1D|rigid:qrEO2DTb2V1nJJbaPAxpzV/0XiQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:P35813 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972|uniprotkb:P35813(identity)|genbank_protein_gi:10337595(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:Q96AV8 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-1386765|uniprotkb:B3KUP8|uniprotkb:A6NC74|uniprotkb:B2RMR7|uniprotkb:B3KTZ5|uniprotkb:B5MED9|ensembl:ENSP00000323246 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:e2f7_human(display_long)|uniprotkb:E2F7(gene name)|psi-mi:E2F7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:NP_976328.2|ensembl:ENSG00000165891(gene)|ensembl:ENST00000322886(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032877"(positive regulation of DNA endoreduplication)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0071930"(negative regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR036388|interpro:IPR036390|mint:Q96AV8|reactome:R-HSA-6804116|uniprotkb:Q96AV8(identity)|genbank_protein_gi:145580626(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:QyyGEJfgxGZZogHf4jQ06CI9ioc9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:Q96LI6 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity)|genbank_protein_gi:32526913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:P28331 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1|uniprotkb:P28331(identity)|genbank_protein_gi:316983154(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:P55008 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-9031341|uniprotkb:A8K406|uniprotkb:O43904|uniprotkb:Q9UIV4|uniprotkb:Q9UKS9|ensembl:ENSP00000365227|ensembl:ENSP00000372966|ensembl:ENSP00000391720|ensembl:ENSP00000397842|ensembl:ENSP00000398013|ensembl:ENSP00000416061 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:aif1_human(display_long)|uniprotkb:AIF1(gene name)|psi-mi:AIF1(display_short)|uniprotkb:G1(gene name synonym)|uniprotkb:IBA1(gene name synonym)|uniprotkb:Ionized calcium-binding adapter molecule 1(gene name synonym)|uniprotkb:Protein G1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:NP_001305899.1|refseq:XP_016865821.1|refseq:NP_001614.3|refseq:NP_116573.1|ensembl:ENSG00000204472(gene)|ensembl:ENSG00000206428(gene)|ensembl:ENSG00000234836(gene)|ensembl:ENSG00000235588(gene)|ensembl:ENSG00000235985(gene)|ensembl:ENSG00000237727(gene)|ensembl:ENST00000376059(transcript)|ensembl:ENST00000383474(transcript)|ensembl:ENST00000413349(transcript)|ensembl:ENST00000414149(transcript)|ensembl:ENST00000425748(transcript)|ensembl:ENST00000440907(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006954"(inflammatory response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014739"(positive regulation of muscle hyperplasia)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0021549"(cerebellum development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0097178"(ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR042433|rcsb pdb:2D58|rcsb pdb:2G2B|go:"GO:0071673"(positive regulation of smooth muscle cell chemotaxis)|uniprotkb:P55008(identity)|genbank_protein_gi:14574568(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:rKN2fpMIkINxzNg3lR1zGwxT7Eg9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96LI6 uniprotkb:Q15276 intact:EBI-3957665|uniprotkb:Q17RC0|uniprotkb:Q7Z4L8|uniprotkb:Q9BZA2|uniprotkb:Q9BZA3|ensembl:ENSP00000303599|ensembl:ENSP00000306549 intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408 psi-mi:hsfy1_human(display_long)|uniprotkb:HSFY1(gene name)|psi-mi:HSFY1(display_short)|uniprotkb:HSFY2(gene name)|psi-mi:HSFY2(display_short)|uniprotkb:HSF2L(gene name synonym)|uniprotkb:HSFY(gene name synonym)|uniprotkb:Heat shock transcription factor 2-like protein(gene name synonym) psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394367|imex:IM-22301-1589 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001877.1|refseq:NP_149099.2|refseq:NP_689797.1|refseq:NP_714927.1|ensembl:ENSG00000169953(gene)|ensembl:ENSG00000172468(gene)|ensembl:ENST00000304790(transcript)|ensembl:ENST00000307393(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000232("Heat shock factor (HSF)-type, DNA-binding")|interpro:IPR027725|interpro:IPR027730|interpro:IPR036388|interpro:IPR036390|refseq:XP_016885520.1|uniprotkb:Q96LI6(identity) refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|uniprotkb:Q15276(identity)|genbank_protein_gi:134152674(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:grGh9Q0MUaspNXflIH6A5orHPEs9606 rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606 intact-crc:675DEAD2AC3F751C|rigid:U2AICcRxltyzC1QaQtYD+avoXGM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q9BTY7 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2|uniprotkb:P0CB43(identity)|genbank_protein_gi:113420249(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:P31948 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q8IWD4 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|genbank_protein_gi:27735133(identity)|entrezgene/locuslink:150275(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q16543 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q86SX1 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-9392873 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q13451 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:O95433 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:O95801 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:P53041 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:O00170 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q15185 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q15785 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1054499|uniprotkb:Q53GH9|uniprotkb:Q6IBN7|uniprotkb:Q9NTZ3|ensembl:ENSP00000361900 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:tom34_human(display_long)|uniprotkb:URCC3(gene name synonym)|uniprotkb:Translocase of outer membrane 34 kDa subunit(gene name synonym)|uniprotkb:TOMM34(gene name)|psi-mi:TOMM34(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_006800.2|ensembl:ENSG00000025772(gene)|ensembl:ENST00000372813(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|uniprotkb:Q15785(identity)|genbank_protein_gi:21361356(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:K0J5GQoRwg/7Yz0p2e41R1wQrME9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q9NZQ9 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-9393504|uniprotkb:Q5JR83|uniprotkb:Q8WVL3|uniprotkb:Q9UKH2|uniprotkb:B7Z6N9|ensembl:ENSP00000295314 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:tmod4_human(display_long)|uniprotkb:TMOD4(gene name)|psi-mi:TMOD4(display_short)|uniprotkb:Skeletal muscle tropomodulin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:XP_011507751.1|refseq:XP_016856578.1|refseq:NP_037485.2|ensembl:ENSG00000163157(gene)|ensembl:ENST00000295314(transcript)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|interpro:IPR004934(Tropomodulin)|interpro:IPR030129|interpro:IPR032675|reactome:R-HSA-390522|uniprotkb:Q9NZQ9(identity)|genbank_protein_gi:156415984(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:ZJGCNYqt6P1kqXDoSEjEhDwksd09606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:K9JA46 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-9392866 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q71U36 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q02790 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q9UNE7 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P08238 uniprotkb:Q9HB71 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394399|imex:IM-22301-1590 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:8D7C37C83A5CF56F|rigid:vAykhMp0Zmlcr7gdNWiu5HF/MBg false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P53992 intact:EBI-9356686 intact:EBI-81134|uniprotkb:Q8WV25|ensembl:ENSP00000321845|ensembl:ENSP00000343405|uniprotkb:B4DZT4 psi-mi:q96be0_human(display_long) psi-mi:sc24c_human(display_long)|uniprotkb:SEC24C(gene name)|psi-mi:SEC24C(display_short)|uniprotkb:KIAA0079(gene name synonym)|uniprotkb:SEC24-related protein C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) go:"GO:0090110"(COPII-coated vesicle cargo loading)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR006895(Zinc finger, Sec23/Sec24-type)|interpro:IPR006896(Sec23/Sec24 trunk region)|interpro:IPR006900(Sec23/Sec24 helical region)|interpro:IPR007123(Gelsolin region)|interpro:IPR012990(Sec23/Sec24 beta-sandwich)|interpro:IPR029006|interpro:IPR036174|interpro:IPR036175|interpro:IPR036180|interpro:IPR036465|interpro:IPR041742|mint:P53992|rcsb pdb:3EH2|rcsb pdb:6PU1|reactome:R-HSA-1655829|reactome:R-HSA-204005|reactome:R-HSA-2132295|reactome:R-HSA-983170|reactome:R-HSA-5694530|ensembl:ENSG00000176986(gene)|ensembl:ENST00000339365(transcript)|ensembl:ENST00000345254(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008270"(zinc ion binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0030127"(COPII vesicle coat)|refseq:NP_004913.2|refseq:NP_940999.1|dip:DIP-30981N|uniprotkb:P53992(identity)|genbank_protein_gi:38373669(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:kOKJkIWFOlIpRFLj5JshAGqAg6s9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q3B7T1 intact:EBI-9356686 intact:EBI-2870947|uniprotkb:B2RC65|uniprotkb:Q8IZ74|uniprotkb:Q3KR40|uniprotkb:Q9Y3W4|uniprotkb:Q5VZQ4|uniprotkb:Q4G190|ensembl:ENSP00000349244 psi-mi:q96be0_human(display_long) psi-mi:edrf1_human(display_long)|uniprotkb:EDRF1(gene name)|psi-mi:EDRF1(display_short)|uniprotkb:C10orf137(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001189367.1|refseq:NP_056423.2|ensembl:ENSG00000107938(gene)|ensembl:ENST00000356792(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|uniprotkb:Q3B7T1(identity)|entrezgene/locuslink:26098(identity)|ddbj/embl/genbank:BC107479(identity)|genbank_protein_gi:31742484(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:VauF5uK1BOHW5dUr9V1XCzY9EPo9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q9NZL4 intact:EBI-9356686 intact:EBI-356763|uniprotkb:O95351|uniprotkb:Q6ZNU5|uniprotkb:B3KQP0|uniprotkb:B4DG11|ensembl:ENSP00000255631|ensembl:ENSP00000398244|ensembl:ENSP00000467574 psi-mi:q96be0_human(display_long) psi-mi:hpbp1_human(display_long)|uniprotkb:HSPBP1(gene name)|psi-mi:HSPBP1(display_short)|uniprotkb:HSPBP(gene name synonym)|uniprotkb:PP1845(orf name)|uniprotkb:Heat shock protein-binding protein 1(gene name synonym)|uniprotkb:Hsp70-interacting protein 1(gene name synonym)|uniprotkb:Hsp70-binding protein 2(gene name synonym)|uniprotkb:Hsp70-interacting protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001123578.1|refseq:NP_036399.3|ensembl:ENSG00000133265(gene)|ensembl:ENST00000255631(transcript)|ensembl:ENST00000433386(transcript)|ensembl:ENST00000587922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006457"(protein folding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013918(Nucleotide exchange factor Fes1)|interpro:IPR016024(Armadillo-type fold)|mint:Q9NZL4|rcsb pdb:1XQR|rcsb pdb:1XQS|refseq:NP_001284529.1|refseq:XP_016882033.1|uniprotkb:Q9NZL4(identity)|genbank_protein_gi:112363070(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:26Au2GesO5ysT/yhYX/0oOO9Md89606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O95816 intact:EBI-9356686 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:q96be0_human(display_long) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q9UNE7 intact:EBI-9356686 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:q96be0_human(display_long) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q9NXW2 intact:EBI-9356686 intact:EBI-358818|uniprotkb:Q9H6H0|uniprotkb:B7Z7I3|ensembl:ENSP00000403313 psi-mi:q96be0_human(display_long) psi-mi:djb12_human(display_long)|uniprotkb:DNAJB12(gene name)|psi-mi:DNAJB12(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001002762.2|refseq:NP_060096.3|ensembl:ENSG00000148719(gene)|ensembl:ENST00000444643(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034622"|go:"GO:0036503"(ERAD pathway)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0071218"(cellular response to misfolded protein)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR015399(Protein of unknown function DUF1977, DnaJ-like)|interpro:IPR018253|interpro:IPR036869|mint:Q9NXW2|rcsb pdb:2CTP|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q9NXW2(identity)|genbank_protein_gi:194306640(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:kt+aES6+wgXo7o1UhFt4E5w9wTs9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q96CP2 intact:EBI-9356686 intact:EBI-9394506|ensembl:ENSP00000293981|ensembl:ENSP00000380159 psi-mi:q96be0_human(display_long) psi-mi:fwch2_human(display_long)|uniprotkb:FLYWCH2(gene name)|psi-mi:FLYWCH2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001135971.1|refseq:NP_001135972.1|refseq:NP_612448.1|refseq:XP_005255135.1|ensembl:ENSG00000162076(gene)|ensembl:ENST00000293981(transcript)|ensembl:ENST00000396958(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR029279|interpro:IPR040312|uniprotkb:Q96CP2(identity)|genbank_protein_gi:215820626(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:hFUp5nK4z8ENLRQK2GSYIqTFljg9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O60884 intact:EBI-9356686 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:q96be0_human(display_long) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|genbank_protein_gi:5031741(identity)|ddbj/embl/genbank:BC013044(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P31689 intact:EBI-9356686 intact:EBI-347834|ensembl:ENSP00000369127|uniprotkb:Q5T7Q0|uniprotkb:Q86TL9 psi-mi:q96be0_human(display_long) psi-mi:dnja1_human(display_long)|uniprotkb:DNAJA1(gene name)|psi-mi:DNAJA1(display_short)|uniprotkb:DNAJ2(gene name synonym)|uniprotkb:HDJ2(gene name synonym)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:HSPF4(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Human DnaJ protein 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:HSDJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000086061(gene)|ensembl:ENST00000330899(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P31689|rcsb pdb:2LO1|rcsb pdb:2M6Y|reactome:R-HSA-3371497|rcsb pdb:6E8M|refseq:NP_001530.1|uniprotkb:P31689(identity)|genbank_protein_gi:4504511(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:YEHeLHYaG2ON2gwuFfqt9Le1Drg9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q71U36 intact:EBI-9356686 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:q96be0_human(display_long) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P50502 intact:EBI-9356686 intact:EBI-357285|ensembl:ENSP00000216218|uniprotkb:O14999|uniprotkb:Q2TU77 psi-mi:q96be0_human(display_long) psi-mi:f10a1_human(display_long)|uniprotkb:ST13(gene name)|psi-mi:ST13(display_short)|uniprotkb:HIP(gene name synonym)|uniprotkb:SNC6(gene name synonym)|uniprotkb:AAG2(gene name synonym)|uniprotkb:Aging-associated protein 2(gene name synonym)|uniprotkb:FAM10A1(gene name synonym)|uniprotkb:Suppression of tumorigenicity 13 protein(gene name synonym)|uniprotkb:Putative tumor suppressor ST13(gene name synonym)|uniprotkb:Protein FAM10A1(gene name synonym)|uniprotkb:Progesterone receptor-associated p48 protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) ensembl:ENSG00000100380(gene)|ensembl:ENST00000216218(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034649|interpro:IPR041243|mint:P50502|rcsb pdb:1UZS|reactome:R-HSA-3371453|refseq:NP_003923.2|uniprotkb:P50502(identity)|genbank_protein_gi:19923193(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:yqG5t4Kuj7ZzfNwlJzGZYscKiM89606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O75190 intact:EBI-9356686 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:q96be0_human(display_long) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q8WXX5 intact:EBI-9356686 intact:EBI-2349100|uniprotkb:B2RMW6|ensembl:ENSP00000362041 psi-mi:q96be0_human(display_long) psi-mi:dnjc9_human(display_long)|uniprotkb:DNAJC9(gene name)|psi-mi:DNAJC9(display_short)|uniprotkb:DnaJ protein SB73(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_056005.1|ensembl:ENSG00000213551(gene)|ensembl:ENST00000372950(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:Q8WXX5|rcsb pdb:7CIZ|rcsb pdb:7CJ0|go:"GO:0005829"(cytosol)|uniprotkb:Q8WXX5(identity)|genbank_protein_gi:27597059(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:K1fhi/D2XXu0PXipEvxGKWyDMMI9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O95817 intact:EBI-9356686 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:q96be0_human(display_long) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q92598 intact:EBI-9356686 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:q96be0_human(display_long) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453|uniprotkb:Q92598(identity)|genbank_protein_gi:42544159(identity)|ddbj/embl/genbank:BC037553(identity)|entrezgene/locuslink:10808(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P18505 intact:EBI-9356686 intact:EBI-3914848|uniprotkb:Q16166|uniprotkb:B2R6U7|uniprotkb:Q8TBK3|ensembl:ENSP00000295454|uniprotkb:D6REL3 psi-mi:q96be0_human(display_long) psi-mi:gbrb1_human(display_long)|uniprotkb:GABRB1(gene name)|psi-mi:GABRB1(display_short)|uniprotkb:"GABA(A) receptor subunit beta-1"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_000803.2|ensembl:ENSG00000163288(gene)|ensembl:ENST00000295454(transcript)|go:"GO:0004890"(GABA-A receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009636"(response to toxic substance)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0022851"(GABA-gated chloride ion channel activity)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032570"(response to progesterone)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034707"(chloride channel complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0050877"(nervous system process)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1902711"(GABA-A receptor complex)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR002289(Gamma-aminobutyric-acid A receptor, beta subunit)|interpro:IPR006028(Gamma-aminobutyric acid A receptor)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|reactome:R-HSA-1236394|reactome:R-HSA-977443|uniprotkb:P18505(identity)|genbank_protein_gi:194097327(identity)|ddbj/embl/genbank:BC022449(identity)|entrezgene/locuslink:2560(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:FE1ChS7kAAGDgLl7T1Leze/bsQw9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P34932 intact:EBI-9356686 intact:EBI-356933|uniprotkb:O95756|uniprotkb:Q2TAL4|uniprotkb:Q9BUK9|ensembl:ENSP00000302961 psi-mi:q96be0_human(display_long) psi-mi:hsp74_human(display_long)|uniprotkb:HSPA4(gene name)|psi-mi:HSPA4(display_short)|uniprotkb:APG2(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-2(gene name synonym)|uniprotkb:HSP70RY(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_002145.3|dip:DIP-460N|ensembl:ENSG00000170606(gene)|ensembl:ENST00000304858(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0045040"(protein insertion into mitochondrial outer membrane)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042052|interpro:IPR043129|mint:P34932|reactome:R-HSA-3371453|uniprotkb:P34932(identity)|genbank_protein_gi:38327039(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:4OkTlG9p3IQQBYloiuHS8+t13TM9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:Q9Y4L1 intact:EBI-9356686 intact:EBI-1054186|uniprotkb:Q2I204|uniprotkb:Q53H25|uniprotkb:B7Z909|uniprotkb:A8C1Z0|ensembl:ENSP00000480150|ensembl:ENSP00000486825 psi-mi:q96be0_human(display_long) psi-mi:hyou1_human(display_long)|uniprotkb:150 kDa oxygen-regulated protein(gene name synonym)|uniprotkb:GRP170(gene name synonym)|uniprotkb:HYOU1(gene name)|psi-mi:HYOU1(display_short)|uniprotkb:ORP150(gene name synonym)|uniprotkb:170 kDa glucose-regulated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_001124463.1|refseq:NP_006380.1|refseq:XP_016872585.1|refseq:XP_016872586.1|ensembl:ENSG00000149428(gene)|ensembl:ENSG00000280682(gene)|ensembl:ENST00000617285(transcript)|ensembl:ENST00000630669(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:Q9Y4L1|reactome:R-HSA-3000484|reactome:R-HSA-381038|go:"GO:0005790"(smooth endoplasmic reticulum)|uniprotkb:Q9Y4L1(identity)|genbank_protein_gi:195976805(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:xqSFRaiiHJLNVqgh87tHx9lfnS49606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P54652 intact:EBI-9356686 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:q96be0_human(display_long) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|genbank_protein_gi:13676857(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O95757 intact:EBI-9356686 intact:EBI-358652|uniprotkb:Q4W5M5|uniprotkb:Q8IWA2|uniprotkb:A2ICT2|ensembl:ENSP00000296464|ensembl:ENSP00000422482 psi-mi:q96be0_human(display_long) psi-mi:hs74l_human(display_long)|uniprotkb:HSPA4L(gene name)|psi-mi:HSPA4L(display_short)|uniprotkb:APG1(gene name synonym)|uniprotkb:OSP94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)|uniprotkb:Heat-shock protein family A member 4-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:O95757|reactome:R-HSA-3371453|refseq:NP_055093.2|refseq:NP_001304310.1|refseq:NP_001304311.1|refseq:NP_001304312.1|go:"GO:0005634"(nucleus)|ensembl:ENSG00000164070(gene)|ensembl:ENST00000296464(transcript)|ensembl:ENST00000508776(transcript)|go:"GO:0005524"(ATP binding)|uniprotkb:O95757(identity)|genbank_protein_gi:31541941(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:6ZoMlI4t4A4u4YsQgrlcwAqjpi49606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:O95429 intact:EBI-9356686 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 psi-mi:q96be0_human(display_long) psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336|uniprotkb:O95429(identity)|genbank_protein_gi:325910869(identity)|ddbj/embl/genbank:BC038505(identity)|entrezgene/locuslink:9530(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96BE0 uniprotkb:P48728 intact:EBI-9356686 intact:EBI-9394494|uniprotkb:Q96IG6|uniprotkb:B4DE61|uniprotkb:B4DJQ0|uniprotkb:E9PBG1|uniprotkb:A8K3I5|ensembl:ENSP00000273588 psi-mi:q96be0_human(display_long) psi-mi:gcst_human(display_long)|uniprotkb:AMT(gene name)|psi-mi:AMT(display_short)|uniprotkb:GCST(gene name synonym)|uniprotkb:Glycine cleavage system T protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394503|imex:IM-22301-1591 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013126(Heat shock protein 70)|interpro:IPR029047|interpro:IPR029048|go:"GO:0005524"(ATP binding)|uniprotkb:Q96BE0(identity)|entrezgene/locuslink:3312(identity)|ddbj/embl/genbank:BC016179(identity) refseq:NP_000472.2|refseq:NP_001158182.1|refseq:NP_001158183.1|refseq:NP_001158184.1|ensembl:ENSG00000145020(gene)|ensembl:ENST00000273588(transcript)|go:"GO:0004047"(aminomethyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0008483"(transaminase activity)|go:"GO:0019464"(glycine decarboxylation via glycine cleavage system)|interpro:IPR006222(Glycine cleavage T-protein, N-terminal)|interpro:IPR006223(Glycine cleavage system T protein)|interpro:IPR013977(Glycine cleavage T-protein, C-terminal barrel)|interpro:IPR027266|interpro:IPR028896|interpro:IPR029043|rcsb pdb:1WSR|rcsb pdb:1WSV|reactome:R-HSA-6783984|uniprotkb:P48728(identity)|genbank_protein_gi:257796254(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r0g8ysaqxjuoTEYOJXAohtnhWio9606 rogid:sauFQRLz5bdEUumx+m/3hxLSK089606 intact-crc:2880D6DB96B76809|rigid:PtgETk42qF6dJIHosDjg4ChNXNI false flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5TA76 uniprotkb:P04792 intact:EBI-9394625|ensembl:ENSP00000335006 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:lce3a_human(display_long)|uniprotkb:LCE3A(gene name)|psi-mi:LCE3A(display_short)|uniprotkb:LEP13(gene name synonym)|uniprotkb:Late envelope protein 13(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394629|imex:IM-22301-1592 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_848518.1|ensembl:ENSG00000185962(gene)|ensembl:ENST00000335674(transcript)|go:"GO:0031424"(keratinization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR028205|reactome:R-HSA-6809371|uniprotkb:Q5TA76(identity)|genbank_protein_gi:30410039(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|genbank_protein_gi:4504517(identity)|ddbj/embl/genbank:BC012292(identity)|entrezgene/locuslink:3315(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:dT2LhEg6i4zDwR+zXc+1K4cfyXs9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:4B94CEA128771CDA|rigid:h68EypHu1X+Zvbv3IlMOHAt2sts false - flag tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P04049 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-365996|uniprotkb:B0LPH8|uniprotkb:Q15278|uniprotkb:Q9UC20|ensembl:ENSP00000251849|uniprotkb:B2R5N3 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:raf1_human(display_long)|uniprotkb:RAF1(gene name)|psi-mi:RAF1(display_short)|uniprotkb:RAF(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) rcsb pdb:3IQV|rcsb pdb:3KUC|rcsb pdb:3KUD|rcsb pdb:3NKX|rcsb pdb:3O8I|rcsb pdb:3OMV|rcsb pdb:4FJ3|rcsb pdb:4G0N|rcsb pdb:4G3X|rcsb pdb:4IEA|rcsb pdb:4IHL|rcsb pdb:6NTC|rcsb pdb:6NTD|rcsb pdb:6PTS|rcsb pdb:6PTW|rcsb pdb:6VJJ|rcsb pdb:6XGU|rcsb pdb:6XGV|rcsb pdb:6XHA|rcsb pdb:6XHB|rcsb pdb:6XI7|ensembl:ENSG00000132155(gene)|ensembl:ENST00000251849(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04049|rcsb pdb:1C1Y|rcsb pdb:1FAQ|rcsb pdb:1FAR|rcsb pdb:1GUA|rcsb pdb:1RFA|rcsb pdb:3CU8|rcsb pdb:3IQJ|rcsb pdb:3IQU|rcsb pdb:7JHP|reactome:R-HSA-2672351|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-5621575|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|refseq:NP_002871.1|refseq:XP_011532276.1|refseq:XP_005265412.1|dip:DIP-1048N|uniprotkb:P04049(identity)|entrezgene/locuslink:5894(identity)|ddbj/embl/genbank:BC018119(identity)|genbank_protein_gi:4506401(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:1WOAPuzcZdMoq9hyFD/qr4Tz7049606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q15185 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9HB71 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P63104 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N|uniprotkb:P63104(identity)|genbank_protein_gi:208973238(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q71U36 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q96D09 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1|uniprotkb:Q96D09(identity)|genbank_protein_gi:19923967(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P27348 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N|uniprotkb:P27348(identity)|genbank_protein_gi:5803227(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P04350 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-355007|uniprotkb:B3KQP4|uniprotkb:Q969E5|ensembl:ENSP00000264071 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:tbb4a_human(display_long)|uniprotkb:TUBB4A(gene name)|psi-mi:TUBB4A(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:Tubulin 5 beta(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_006078.2|ensembl:ENSG00000104833(gene)|ensembl:ENST00000264071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0033269"(internode region of axon)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|go:"GO:0031115"(negative regulation of microtubule polymerization)|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P04350|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001276052.1|refseq:NP_001276056.1|refseq:NP_001276058.1|refseq:NP_001276059.1|refseq:NP_001276060.1|uniprotkb:P04350(identity)|genbank_protein_gi:21361322(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:mMveBNZkQs2x0dyHm/ghVWBe4/49606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q14257 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1|uniprotkb:Q14257(identity)|entrezgene/locuslink:5955(identity)|genbank_protein_gi:426214088(identity)|ddbj/embl/genbank:BC004892(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P61981 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N|uniprotkb:P61981(identity)|genbank_protein_gi:21464101(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q96EY1 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-356767|uniprotkb:O75472|uniprotkb:Q8WUJ6|uniprotkb:Q8WXJ3|uniprotkb:Q96D76|uniprotkb:Q96IV1|uniprotkb:Q9NYH8|uniprotkb:B2RAJ5|uniprotkb:B4DI33|uniprotkb:E7ES32|ensembl:ENSP00000262375|ensembl:ENSP00000477570 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:dnja3_human(display_long)|uniprotkb:DNAJA3(gene name)|psi-mi:DNAJA3(display_short)|uniprotkb:TID1(gene name synonym)|uniprotkb:HCA57(gene name synonym)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001273445.1|refseq:NP_001128582.1|refseq:NP_005138.3|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|mint:Q96EY1|rcsb pdb:2CTT|rcsb pdb:2DN9|rcsb pdb:6IWS|ensembl:ENSG00000103423(gene)|ensembl:ENSG00000276726(gene)|ensembl:ENST00000262375(transcript)|ensembl:ENST00000612103(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|dip:DIP-33870N|uniprotkb:Q96EY1(identity)|genbank_protein_gi:205360838(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:WnRYdQ9E3yGbSlq1SSGTX9k+3uA9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9Y2I1 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-2688731|uniprotkb:Q6PIB4|uniprotkb:Q9UEU4|uniprotkb:Q7L8M3|uniprotkb:Q6PGP3|uniprotkb:Q9UFW3|uniprotkb:Q7Z2X6|uniprotkb:Q9UES6|uniprotkb:C9J245|ensembl:ENSP00000339958|ensembl:ENSP00000418232 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:nisch_human(display_long)|uniprotkb:IRAS(gene name synonym)|uniprotkb:KIAA0975(gene name synonym)|uniprotkb:Imidazoline receptor 1(gene name synonym)|uniprotkb:Imidazoline receptor antisera-selected protein(gene name synonym)|uniprotkb:Imidazoline-1 receptor(gene name synonym)|uniprotkb:Imidazoline-1 receptor candidate protein(gene name synonym)|uniprotkb:NISCH(gene name)|psi-mi:NISCH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_009115.2|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048243"(norepinephrine secretion)|go:"GO:0055037"(recycling endosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001683(Phox-like)|interpro:IPR032675|interpro:IPR036871|interpro:IPR037904|mint:Q9Y2I1|rcsb pdb:3P0C|reactome:R-HSA-9013149|reactome:R-HSA-9696264|reactome:R-HSA-9696270|ensembl:ENSG00000010322(gene)|ensembl:ENST00000345716(transcript)|ensembl:ENST00000479054(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|refseq:NP_001263222.1|refseq:NP_001263223.1|uniprotkb:Q9Y2I1(identity)|entrezgene/locuslink:11188(identity)|genbank_protein_gi:66472382(identity)|ddbj/embl/genbank:BC056900(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:GuBgG6MUrD5p1hIhGGmrtCjT0jQ9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P07858 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N|uniprotkb:P07858(identity)|genbank_protein_gi:22538431(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P53041 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q93008 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-302524|intact:EBI-1058656|intact:EBI-28978998|ensembl:ENSP00000367558|uniprotkb:O75550|uniprotkb:Q8WWT3|uniprotkb:Q8WX12 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:usp9x_human(display_long)|uniprotkb:USP9X(gene name)|psi-mi:USP9X(display_short)|uniprotkb:DFFRX(gene name synonym)|uniprotkb:USP9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease FAF-X(gene name synonym)|uniprotkb:Deubiquitinating enzyme FAF-X(gene name synonym)|uniprotkb:Fat facets protein-related, X-linked(gene name synonym)|uniprotkb:Ubiquitin-specific protease 9, X chromosome(gene name synonym)|uniprotkb:FAM(gene name synonym)|uniprotkb:Fat facets in mammals(gene name synonym)|uniprotkb:Ubiquitin thioesterase FAF-X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000124486(gene)|ensembl:ENST00000378308(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001764"(neuron migration)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007292"(female gamete generation)|go:"GO:0008104"(protein localization)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030426"(growth cone)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-2173795|reactome:R-HSA-5689880|reactome:R-HSA-8866652|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9033241|reactome:R-HSA-977225|go:"GO:0048675"(axon extension)|refseq:NP_001034679.2|refseq:NP_001034680.2|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018200|interpro:IPR021905|interpro:IPR028889|interpro:IPR031226|interpro:IPR038765|mint:Q93008|rcsb pdb:5VBD|rcsb pdb:5WCH|ensembl:ENST00000324545|ensembl:ENSP00000316357|ensembl:ENSP00000367558|dip:DIP-27562N|uniprotkb:Q93008(identity)|genbank_protein_gi:145309309(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:f9AWz8rAV8rMTqcQ46VrYYLTHq89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9Y5V3 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889|uniprotkb:Q9Y5V3(identity)|ddbj/embl/genbank:BC032473(identity)|genbank_protein_gi:52632377(identity)|entrezgene/locuslink:9500(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:O00459 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-346930|uniprotkb:Q5EAT5|uniprotkb:Q9UPH9|intact:EBI-28974273|ensembl:ENSP00000222254 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:p85b_human(display_long)|uniprotkb:PIK3R2(gene name)|psi-mi:PIK3R2(display_short)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSP00000222254|refseq:NP_005018.1|dip:DIP-31811N|ensembl:ENSG00000105647(gene)|ensembl:ENST00000222254(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|rcsb pdb:6OX7|rcsb pdb:6U28|reactome:R-HSA-109704|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-186763|reactome:R-HSA-198203|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|mint:O00459|rcsb pdb:2KT1|rcsb pdb:2XS6|rcsb pdb:3MTT|rcsb pdb:3O5Z|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-210993|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9013409|uniprotkb:O00459(identity)|genbank_protein_gi:4826908(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:Ij0WS0eKPwShgFWQc7OEss7AcAU9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P62258 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|uniprotkb:P62258(identity)|genbank_protein_gi:5803225(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9UNF1 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-725832|uniprotkb:O76058|uniprotkb:Q5BJF3|uniprotkb:Q8NAL6|uniprotkb:Q9H218|uniprotkb:Q9P0U9|uniprotkb:A6NMX0|uniprotkb:Q9UM52|ensembl:ENSP00000218439|ensembl:ENSP00000364193|ensembl:ENSP00000364198|ensembl:ENSP00000364209|ensembl:ENSP00000379526 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:magd2_human(display_long)|uniprotkb:MAGE-D2 antigen(gene name synonym)|uniprotkb:Breast cancer-associated gene 1 protein(gene name synonym)|uniprotkb:11B6(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein JCL-1(gene name synonym)|uniprotkb:MAGED2(gene name)|psi-mi:MAGED2(display_short)|uniprotkb:BCG1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_055414.2|refseq:NP_803182.1|refseq:NP_957516.1|ensembl:ENSG00000102316(gene)|ensembl:ENST00000218439(transcript)|ensembl:ENST00000375053(transcript)|ensembl:ENST00000375058(transcript)|ensembl:ENST00000375068(transcript)|ensembl:ENST00000396224(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0016020"(membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9UNF1|reactome:R-HSA-114608|dip:DIP-50722N|uniprotkb:Q9UNF1(identity)|genbank_protein_gi:19387846(identity)|entrezgene/locuslink:10916(identity)|ddbj/embl/genbank:BC000304(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:fXavezmKy58aGuVgzvDYjwNw3B89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9BUF5 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1|uniprotkb:Q9BUF5(identity)|genbank_protein_gi:14210536(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:O00499 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-719094|uniprotkb:Q659B7|uniprotkb:O00297|uniprotkb:O00545|uniprotkb:O43867|uniprotkb:O60552|uniprotkb:O60553|uniprotkb:O60554|uniprotkb:O60555|uniprotkb:O75514|uniprotkb:O75515|uniprotkb:O75516|uniprotkb:O75517|uniprotkb:O75518|uniprotkb:Q92944|uniprotkb:Q99688|intact:EBI-1760307|intact:EBI-1965383|intact:EBI-28970933|ensembl:ENSP00000316779 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:bin1_human(display_long)|uniprotkb:Bridging integrator 1(gene name synonym)|uniprotkb:Amphiphysin-like protein(gene name synonym)|uniprotkb:Box-dependent myc-interacting protein 1(gene name synonym)|uniprotkb:BIN1(gene name)|psi-mi:BIN1(display_short)|uniprotkb:AMPHL(gene name synonym)|uniprotkb:Amphiphysin II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENST00000259238|ensembl:ENSP00000259238|ensembl:ENSP00000316779|ensembl:ENST00000346226|ensembl:ENSP00000315411|ensembl:ENST00000348750|ensembl:ENSP00000259237|ensembl:ENST00000351659|ensembl:ENSP00000315388|ensembl:ENST00000352848|ensembl:ENSP00000315284|ensembl:ENST00000357970|ensembl:ENSP00000350654|ensembl:ENST00000376113|ensembl:ENSP00000365281|ensembl:ENST00000393040|ensembl:ENSP00000376760|ensembl:ENST00000393041|ensembl:ENSP00000376761|ensembl:ENST00000409400|ensembl:ENSP00000386797|refseq:NP_004296.1|refseq:NP_647593.1|refseq:NP_647594.1|refseq:NP_647595.1|refseq:NP_647596.1|refseq:NP_647597.1|refseq:NP_647598.1|refseq:NP_647599.1|refseq:NP_647600.1|refseq:NP_647601.1|refseq:NP_001307561.1|refseq:NP_001307562.1|refseq:NP_001307569.1|refseq:NP_001307570.1|refseq:NP_001307571.1|go:"GO:0060988"(lipid tube assembly)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903946"(negative regulation of ventricular cardiac muscle cell action potential)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001452(Src homology-3)|interpro:IPR003005(Amphiphysin)|interpro:IPR003023(Amphiphysin, isoform 2)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR035471|interpro:IPR036028|mint:O00499|rcsb pdb:1MUZ|rcsb pdb:1MV0|rcsb pdb:1MV3|rcsb pdb:2FIC|rcsb pdb:2RMY|rcsb pdb:2RND|rcsb pdb:5I22|reactome:R-HSA-8856828|go:"GO:0060987"(lipid tube)|ensembl:ENSG00000136717(gene)|ensembl:ENST00000316724(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006997"(nucleus organization)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030018"(Z disc)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031674"(I band)|go:"GO:0031982"(vesicle)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033292"(T-tubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043194"(axon initial segment)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|dip:DIP-41480N|uniprotkb:O00499(identity)|genbank_protein_gi:21536400(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:/3GFhR2reRqrmR19lWj5ErWP0N49606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q08E93 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-2602739 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:f27e3_human(display_long)|uniprotkb:FAM27E3(gene name)|psi-mi:FAM27E3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) interpro:IPR031672|uniprotkb:Q08E93(identity)|genbank_protein_gi:397138518(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:qfzRd8SarqEutJVLmAiodLNtUOU9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P13674 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1237386|uniprotkb:Q15082|uniprotkb:Q15083|uniprotkb:Q5VSQ5|uniprotkb:C9JL12|ensembl:ENSP00000307318|ensembl:ENSP00000378353 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:p4ha1_human(display_long)|uniprotkb:P4HA1(gene name)|psi-mi:P4HA1(display_short)|uniprotkb:P4HA(gene name synonym)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_000908.2|refseq:NP_001017962.1|refseq:NP_001136067.1|refseq:NP_001136068.1|dip:DIP-38180N|ensembl:ENSG00000122884(gene)|ensembl:ENST00000307116(transcript)|ensembl:ENST00000394890(transcript)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR019734|mint:P13674|rcsb pdb:1TJC|rcsb pdb:2V5F|rcsb pdb:2YQ8|rcsb pdb:4BT8|rcsb pdb:4BT9|rcsb pdb:4BTA|rcsb pdb:4BTB|reactome:R-HSA-1650814|go:"GO:0043231"(intracellular membrane-bounded organelle)|uniprotkb:P13674(identity)|genbank_protein_gi:217272849(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:Yo9hgWVJ5iUGITVWKfvjhTNX1lk9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9BZK7 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-765729|uniprotkb:Q14DC3|uniprotkb:Q9H2I1|uniprotkb:Q9H9A1|uniprotkb:D3DNQ9|ensembl:ENSP00000263964|ensembl:ENSP00000387849|ensembl:ENSP00000405574|ensembl:ENSP00000413251|ensembl:ENSP00000501274 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:tbl1r_human(display_long)|uniprotkb:Transducin beta-like 1X-related protein 1(gene name synonym)|uniprotkb:Nuclear receptor corepressor/HDAC3 complex subunit TBLR1(gene name synonym)|uniprotkb:TBL1-related protein 1(gene name synonym)|uniprotkb:TBL1XR1(gene name)|psi-mi:TBL1XR1(display_short)|uniprotkb:IRA1(gene name synonym)|uniprotkb:TBLR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_078941.2|refseq:XP_011511443.1|refseq:XP_011511444.1|refseq:XP_011511445.1|refseq:NP_001308123.1|refseq:NP_001308124.1|refseq:NP_001308122.1|refseq:XP_005247832.1|refseq:XP_006713809.1|refseq:XP_016862674.1|dip:DIP-34582N|ensembl:ENSG00000177565(gene)|ensembl:ENST00000422442(transcript)|ensembl:ENST00000352800(transcript)|ensembl:ENST00000430069(transcript)|ensembl:ENST00000457928(transcript)|ensembl:ENST00000673974(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9BZK7|rcsb pdb:4LG9|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|uniprotkb:Q9BZK7(identity)|genbank_protein_gi:19913371(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:Sr6jJZT7jdfR/ps1xK1ySq9/TuI9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q15293 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1|uniprotkb:Q15293(identity)|entrezgene/locuslink:5954(identity)|genbank_protein_gi:4506455(identity)|ddbj/embl/genbank:BC010120(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:O15460 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-348033|ensembl:ENSP00000166534|ensembl:ENSP00000368398|ensembl:ENSP00000384999|uniprotkb:Q8WWN0|uniprotkb:D3DQ85|uniprotkb:D3DQ86 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:p4ha2_human(display_long)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENST00000166534(transcript)|ensembl:ENST00000379104(transcript)|ensembl:ENST00000401867(transcript)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0009055"(electron transfer activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR019734|mint:O15460|rcsb pdb:6EVL|rcsb pdb:6EVM|rcsb pdb:6EVN|rcsb pdb:6EVO|rcsb pdb:6EVP|reactome:R-HSA-1650814|ensembl:ENSG00000072682(gene)|refseq:NP_001136071.1|refseq:NP_004190.1|refseq:NP_001017973.1|refseq:NP_001017974.1|refseq:NP_001136070.1|refseq:XP_016865500.1|refseq:XP_005272173.1|refseq:XP_005272174.1|refseq:XP_005272175.1|refseq:XP_005272176.1|refseq:XP_005272177.1|refseq:XP_006714791.1|refseq:XP_006714792.1|refseq:XP_006714793.1|uniprotkb:O15460(identity)|genbank_protein_gi:217272861(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:VppOE5KSA6wKWCFN4mCUJsFHDIA9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q04917 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|uniprotkb:Q04917(identity)|genbank_protein_gi:4507951(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P27986 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N|uniprotkb:P27986(identity)|genbank_protein_gi:32455248(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q13451 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9NNW5 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1568315|uniprotkb:B4DHK2|uniprotkb:Q3MIT1|uniprotkb:Q9UF63|ensembl:ENSP00000477389 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:wdr6_human(display_long)|uniprotkb:WDR6(gene name)|psi-mi:WDR6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_060501.3|refseq:NP_001307475.1|refseq:NP_001307476.1|ensembl:ENSG00000178252(gene)|ensembl:ENST00000608424(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0030488"(tRNA methylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9NNW5|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|uniprotkb:Q9NNW5(identity)|genbank_protein_gi:197927448(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:gYSDkyuDdKhj387/1P3bhpKJXy89606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9H078 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078|uniprotkb:Q9H078(identity)|genbank_protein_gi:13540606(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P04792 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N|uniprotkb:P04792(identity)|genbank_protein_gi:4504517(identity)|ddbj/embl/genbank:BC012292(identity)|entrezgene/locuslink:3315(identity) psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q92569 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1|uniprotkb:Q92569(identity)|genbank_protein_gi:166795245(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 intact:EBI-9394644 intact:EBI-356594|ensembl:ENSP00000505547 - psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:k7ek91_human(display_short)|psi-mi:EBI-9394644(display_long)|uniprotkb:DNAH17(gene name)|psi-mi:DNAH17(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) uniprotkb:K7EK91(uniprot-removed-ac)|uniprotkb:K7EK91(identity)|genbank_protein_gi:256542310(identity) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:N3niT1LXahhhnciyEsyF117Ec0Y9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:P31946 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N|uniprotkb:P31946(identity)|genbank_protein_gi:21328448(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:O43852 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-1171069|uniprotkb:O60456|uniprotkb:Q6FHB9|uniprotkb:Q96RL3|uniprotkb:Q9NR43|intact:EBI-2554631|uniprotkb:B3KPG9|uniprotkb:D6QS48|uniprotkb:D6QS49|uniprotkb:D6QS50|uniprotkb:D6QS51|uniprotkb:D6QS52|uniprotkb:D6QS53|uniprotkb:D6QS54|uniprotkb:D6QS55|uniprotkb:D6QS56|uniprotkb:D6QS57|uniprotkb:D6QS58|uniprotkb:D6QS59|uniprotkb:F5H1Q9|uniprotkb:F5H879|ensembl:ENSP00000249364 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:calu_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:IEF SSP 9302(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001124146.1|refseq:NP_001186602.1|refseq:NP_001210.1|refseq:NP_001186600.1|refseq:NP_001186601.1|ensembl:ENSG00000128595(gene)|ensembl:ENST00000249364(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O43852|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016868148.1|uniprotkb:O43852(identity)|entrezgene/locuslink:813(identity)|genbank_protein_gi:194578885(identity)|ddbj/embl/genbank:BC013383(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q92538 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-359050|uniprotkb:Q5VXX3|uniprotkb:Q96CK6|uniprotkb:Q96HZ3|uniprotkb:Q9H473|uniprotkb:Q149P0|uniprotkb:Q149P1|ensembl:ENSP00000503207|ensembl:ENSP00000503981 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:gbf1_human(display_long)|uniprotkb:GBF1(gene name)|psi-mi:GBF1(display_short)|uniprotkb:KIAA0248(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001186307.1|refseq:NP_001186308.1|refseq:NP_004184.1|ensembl:ENSP00000503207|ensembl:ENSP00000503981|ensembl:ENST00000676993|ensembl:ENSP00000503918|ensembl:ENST00000677240|ensembl:ENSP00000503428|ensembl:ENSG00000107862(gene)|ensembl:ENST00000676513(transcript)|ensembl:ENST00000676939(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002263"(cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031252"(cell leading edge)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0060271"(cilium assembly)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097111"(endoplasmic reticulum-Golgi intermediate compartment organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|go:"GO:1903420"(protein localization to endoplasmic reticulum tubular network)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR000904(SEC7-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032691|interpro:IPR035999|mint:Q92538|reactome:R-HSA-199992|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434|uniprotkb:Q92538(identity)|genbank_protein_gi:313747582(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:4rA/2NVw35m+b6O7/+9noI3EO4o9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:O60884 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|genbank_protein_gi:5031741(identity)|ddbj/embl/genbank:BC013044(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O14654 uniprotkb:Q9ULX6 intact:EBI-356594|ensembl:ENSP00000505547 intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557 psi-mi:irs4_human(display_long)|uniprotkb:IRS4(gene name)|psi-mi:IRS4(display_short)|uniprotkb:160 kDa phosphotyrosine protein(gene name synonym)|uniprotkb:Phosphoprotein of 160 kDa(gene name synonym) psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394652|imex:IM-22301-1593 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000505547|refseq:NP_003595.1|ensembl:ENSG00000133124(gene)|ensembl:ENST00000564206(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|reactome:R-HSA-2428928|uniprotkb:O14654(identity)|entrezgene/locuslink:8471(identity)|genbank_protein_gi:4504733(identity) refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6|uniprotkb:Q9ULX6(identity)|genbank_protein_gi:49472841(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2020/10/21 rogid:iKGsWaKu2XsU4OGaxhDG8wjcmVc9606 rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606 intact-crc:7D1618FFDC794AED|rigid:l7ZCmVuas4WB8DR0hZI1p8KIY18 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:P10276 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-413374|uniprotkb:P78456|uniprotkb:Q13440|uniprotkb:Q13441|uniprotkb:Q96S41|uniprotkb:Q9NQS0|uniprotkb:B8Y636|ensembl:ENSP00000254066|ensembl:ENSP00000377649 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:rara_human(display_long)|uniprotkb:RARA(gene name)|psi-mi:RARA(display_short)|uniprotkb:NR1B1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_000955.1|refseq:NP_001019980.1|refseq:NP_001138773.1|refseq:XP_011523397.1|refseq:NP_001138774.1|refseq:XP_005257610.1|refseq:XP_005257611.1|ensembl:ENSG00000131759(gene)|ensembl:ENST00000254066(transcript)|ensembl:ENST00000394089(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001889"(liver development)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007281"(germ cell development)|go:"GO:0007565"(female pregnancy)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030850"(prostate gland development)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0034097"(response to cytokine)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060010"(Sertoli cell fate commitment)|go:"GO:0060173"(limb development)|go:"GO:0060324"(face development)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0061037"(negative regulation of cartilage development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10276|rcsb pdb:1DKF|rcsb pdb:1DSZ|rcsb pdb:3A9E|rcsb pdb:3KMR|rcsb pdb:3KMZ|rcsb pdb:4DQM|rcsb pdb:5K13|rcsb pdb:6XWG|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9616222|reactome:R-HSA-383280|dip:DIP-34N|uniprotkb:P10276(identity)|ddbj/embl/genbank:BC008727(identity)|genbank_protein_gi:223718064(identity)|entrezgene/locuslink:5914(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:hxW9W0aqa3qEJT5ZilJdJ4b+gEo9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:Q15014 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-399257|uniprotkb:B3KP92|uniprotkb:Q567V0|uniprotkb:Q8J026|uniprotkb:D3DXA5|ensembl:ENSP00000353643|ensembl:ENSP00000391969|ensembl:ENSP00000410532|ensembl:ENSP00000415476 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:mo4l2_human(display_long)|uniprotkb:MORF4L2(gene name)|psi-mi:MORF4L2(display_short)|uniprotkb:KIAA0026(gene name synonym)|uniprotkb:MRGX(gene name synonym)|uniprotkb:MORF-related gene X protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRGX(gene name synonym)|uniprotkb:Protein MSL3-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_001135894.1|refseq:NP_001135895.1|refseq:NP_001135896.1|refseq:NP_001135897.1|refseq:NP_001135898.1|refseq:NP_001135899.1|refseq:NP_001135900.1|refseq:NP_001135901.1|refseq:NP_001135902.1|refseq:NP_001135903.1|refseq:NP_001135904.1|refseq:NP_036418.1|refseq:NP_001135890.1|refseq:NP_001135891.1|refseq:NP_001135892.1|refseq:NP_001135893.1|ensembl:ENSG00000123562(gene)|ensembl:ENST00000360458(transcript)|ensembl:ENST00000433176(transcript)|ensembl:ENST00000441076(transcript)|ensembl:ENST00000451301(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051155"(positive regulation of striated muscle cell differentiation)|interpro:IPR008676(MRG)|interpro:IPR026541|interpro:IPR038012|interpro:IPR038217|mint:Q15014|reactome:R-HSA-3214847|uniprotkb:Q15014(identity)|genbank_protein_gi:215490021(identity)|ddbj/embl/genbank:BC056899(identity)|entrezgene/locuslink:9643(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:7SlnJWNVhfdzirTHBEseWbJQjyU9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:Q9HAV4 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6|uniprotkb:Q9HAV4(identity)|genbank_protein_gi:22748937(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:Q15435 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-1024281|uniprotkb:Q9UQE5|uniprotkb:Q9UQE6|uniprotkb:Q9Y6K4|ensembl:ENSP00000234038|uniprotkb:B4DFD4|ensembl:ENSP00000385657|uniprotkb:B5MCY6 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:pp1r7_human(display_long)|uniprotkb:Protein phosphatase 1 regulatory subunit 22(gene name synonym)|uniprotkb:PPP1R7(gene name)|psi-mi:PPP1R7(display_short)|uniprotkb:SDS22(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) ensembl:ENSG00000115685(gene)|refseq:NP_002703.1|ensembl:ENST00000234038(transcript)|ensembl:ENST00000407025(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|rcsb pdb:6HKW|rcsb pdb:6MKY|rcsb pdb:6OBN|rcsb pdb:6OBP|refseq:NP_001269338.1|refseq:NP_001269339.1|refseq:NP_001269340.1|refseq:NP_001269341.1|refseq:NP_001269342.1|refseq:NP_001269343.1|dip:DIP-1005N|uniprotkb:Q15435(identity)|genbank_protein_gi:4506013(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:HKHhTMtEgPpOdf/lS59bZAOrDjk9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:Q9BRP1 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-2372173|ensembl:ENSP00000246535 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:pdd2l_human(display_long)|uniprotkb:PDCD2L(gene name)|psi-mi:PDCD2L(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_115722.1|ensembl:ENSG00000126249(gene)|ensembl:ENST00000246535(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|uniprotkb:Q9BRP1(identity)|genbank_protein_gi:14150141(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:ZTXFLP80bsA3zOpzcNG/1qClozE9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:O00469 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-1047459|uniprotkb:Q59ED2|uniprotkb:Q8N170|intact:EBI-2559757|uniprotkb:B3KWS3|ensembl:ENSP00000353170 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:plod2_human(display_long)|uniprotkb:Lysyl hydroxylase 2(gene name synonym)|uniprotkb:PLOD2(gene name)|psi-mi:PLOD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_000926.2|refseq:NP_891988.1|ensembl:ENSG00000152952(gene)|ensembl:ENST00000360060(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0046947"(hydroxylysine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR029044|mint:O00469|reactome:R-HSA-1650814|uniprotkb:O00469(identity)|ddbj/embl/genbank:BC037169(identity)|entrezgene/locuslink:5352(identity)|genbank_protein_gi:33636742(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:sNgFtZzNoKBCz7KUhTBfMG/xxas9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:Q99755 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-726414|uniprotkb:Q99754|uniprotkb:Q99756|uniprotkb:B4DIN0|uniprotkb:A8K4Q0|ensembl:ENSP00000357883 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:pi51a_human(display_long)|uniprotkb:PIP5K1A(gene name)|psi-mi:PIP5K1A(display_short)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_001129108.1|refseq:NP_001129109.1|refseq:NP_001129110.1|refseq:NP_003548.1|refseq:NP_001317618.1|ensembl:ENSG00000143398(gene)|ensembl:ENST00000368888(transcript)|go:"GO:0000285"(1-phosphatidylinositol-3-phosphate 5-kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006650"(glycerophospholipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0019900"(kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0052810"(1-phosphatidylinositol-5-kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097178"(ruffle assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-HSA-1660499|reactome:R-HSA-6811558|dip:DIP-60649N|uniprotkb:Q99755(identity)|genbank_protein_gi:208431774(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:jDE/jXrUlbohCr2mZjEgIxTVzjU9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:P13631 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-2568901|uniprotkb:B7ZAE4|uniprotkb:P22932|uniprotkb:Q15281|uniprotkb:Q52LZ8|uniprotkb:Q9BYX8|uniprotkb:Q9H1I3|uniprotkb:Q9UJ38|ensembl:ENSP00000388510|uniprotkb:B7Z492|uniprotkb:B7Z4F1|uniprotkb:J3KNP6 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:rarg_human(display_long)|uniprotkb:RARG(gene name)|psi-mi:RARG(display_short)|uniprotkb:NR1B3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_000957.1|refseq:NP_001036193.1|ensembl:ENSG00000172819(gene)|ensembl:ENST00000425354(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001843"(neural tube closure)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0045637"(regulation of myeloid cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060324"(face development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0070384"(Harderian gland development)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P13631|rcsb pdb:1EXA|rcsb pdb:1EXX|rcsb pdb:1FCX|rcsb pdb:1FCY|rcsb pdb:1FCZ|rcsb pdb:1FD0|rcsb pdb:2LBD|rcsb pdb:3LBD|rcsb pdb:4LBD|rcsb pdb:5M24|rcsb pdb:6FX0|reactome:R-HSA-383280|reactome:R-HSA-5362517|reactome:R-HSA-5617472|refseq:NP_001230659.1|refseq:NP_001230661.1|uniprotkb:P13631(identity)|genbank_protein_gi:112181200(identity)|ddbj/embl/genbank:BC093729(identity)|entrezgene/locuslink:5916(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:LjFZzg5/Yzc4luYaSTie0DcdeHU9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:P37108 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-353399|uniprotkb:Q6B0K5|intact:EBI-1053250|uniprotkb:Q96Q14|uniprotkb:B5BUF5|ensembl:ENSP00000267884 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:srp14_human(display_long)|uniprotkb:SRP14(gene name)|psi-mi:SRP14(display_short)|uniprotkb:18 kDa Alu RNA-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_003125.3|dip:DIP-6152N|ensembl:ENSG00000140319(gene)|ensembl:ENST00000267884(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0045047"(protein targeting to ER)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003210(Signal recognition particle, SRP14 subunit)|interpro:IPR009018(Signal recognition particle, SRP9/SRP14 subunit)|mint:P37108|rcsb pdb:1E8O|rcsb pdb:1E8S|rcsb pdb:1RY1|rcsb pdb:4UYJ|rcsb pdb:4UYK|rcsb pdb:5AOX|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-6798695|uniprotkb:P37108(identity)|genbank_protein_gi:149999611(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:0xHelIgJbXaUrFsHGoj1wDQKdPs9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKP3 uniprotkb:P10826 intact:EBI-5659717|uniprotkb:Q32N04|ensembl:ENSP00000362935|uniprotkb:Q549J7 intact:EBI-2568838|uniprotkb:P12891|uniprotkb:Q00989|uniprotkb:Q15298|uniprotkb:Q9UN48 psi-mi:itbp2_human(display_long)|uniprotkb:Melusin(gene name synonym)|uniprotkb:MSTP015(orf name)|uniprotkb:ITGB1BP2(gene name)|psi-mi:ITGB1BP2(display_short) psi-mi:rarb_human(display_long)|uniprotkb:RARB(gene name)|psi-mi:RARB(display_short)|uniprotkb:HAP(gene name synonym)|uniprotkb:NR1B2(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group B member 2(gene name synonym)|uniprotkb:RAR-epsilon(gene name synonym)|uniprotkb:HBV-activated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394839|imex:IM-22301-1594 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000147166(gene)|ensembl:ENST00000373829(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0007165"(signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030018"(Z disc)|interpro:IPR007051(CHORD)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|interpro:IPR007052(CS domain)|refseq:NP_036410.1|uniprotkb:Q9UKP3(identity) refseq:NP_000956.2|refseq:NP_057236.1|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR003078(Retinoic acid receptor)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002068"(glandular epithelial cell development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0021756"(striatum development)|go:"GO:0022008"(neurogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0007165"(signal transduction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|rcsb pdb:1HRA|rcsb pdb:1XAP|rcsb pdb:4DM6|rcsb pdb:4DM8|rcsb pdb:4JYG|rcsb pdb:4JYH|rcsb pdb:4JYI|rcsb pdb:5UAN|rcsb pdb:6SSQ|reactome:R-HSA-383280|reactome:R-HSA-5362517|reactome:R-HSA-5617472|refseq:NP_001277195.1|refseq:NP_001277205.1|refseq:NP_001277145.1|refseq:NP_001277146.1|interpro:IPR035500|mint:P10826|uniprotkb:P10826(identity)|genbank_protein_gi:14916494(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:ATXkBI3+UoEgYYVG97Eab5OtGZE9606 rogid:GviMMhEdTqNBuvQ8p2XTKxllgdc9606 intact-crc:1E4EA9541985E40A|rigid:MdO0biSo+B/UkhWw7Dak4M5Zf/k false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86X45 uniprotkb:Q14160 intact:EBI-9379658|uniprotkb:Q13648|uniprotkb:Q4G183|ensembl:ENSP00000429791|ensembl:ENSP00000484634 intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756 psi-mi:daa11_human(display_long)|uniprotkb:DNAAF11(gene name)|psi-mi:DNAAF11(display_short)|uniprotkb:LRRC6(gene name synonym)|uniprotkb:LRTP(gene name synonym)|uniprotkb:Leucine-rich repeat-containing protein 6(gene name synonym)|uniprotkb:Leucine-rich testis-specific protein(gene name synonym)|uniprotkb:Protein tilB homolog(gene name synonym)|uniprotkb:TSLRP(gene name synonym)|uniprotkb:Testis-specific leucine-rich repeat protein(gene name synonym) psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394895|imex:IM-22301-1595 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001308890.1|refseq:NP_001308891.1|refseq:NP_001308892.1|refseq:NP_001308893.1|refseq:NP_001308894.1|refseq:NP_001308895.1|refseq:NP_036604.2|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR007052(CS domain)|interpro:IPR032675|mint:Q86X45|ensembl:ENSG00000129295(gene)|ensembl:ENST00000519595(transcript)|ensembl:ENST00000620350(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0008584"(male gonad development)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0036158"(outer dynein arm assembly)|go:"GO:0036159"(inner dynein arm assembly)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0051649"(establishment of localization in cell)|go:"GO:0060287"(epithelial cilium movement involved in determination of left/right asymmetry)|go:"GO:0061458"(reproductive system development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0090651"(apical cytoplasm)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0120229"(protein localization to motile cilium)|uniprotkb:Q86X45(identity)|ddbj/embl/genbank:BC047286(identity)|entrezgene/locuslink:23639(identity) refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270|uniprotkb:Q14160(identity)|genbank_protein_gi:355390313(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:+KWpDTd1pD7UAK4rVDo5We0inVw9606 rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606 intact-crc:65EBEDA681EF1043|rigid:2DMAzXrZRiewGkYIZUhnYp+BrG4 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:P49736 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N|uniprotkb:P49736(identity)|ddbj/embl/genbank:BC007670(identity)|genbank_protein_gi:33356547(identity)|entrezgene/locuslink:4171(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:P33992 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N|uniprotkb:P33992(identity)|genbank_protein_gi:23510448(identity)|ddbj/embl/genbank:BC000142(identity)|entrezgene/locuslink:4174(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:P25205 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N|uniprotkb:P25205(identity)|entrezgene/locuslink:4172(identity)|ddbj/embl/genbank:BC001626(identity)|genbank_protein_gi:394582093(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:Q14145 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z|uniprotkb:Q14145(identity)|entrezgene/locuslink:9817(identity)|genbank_protein_gi:22027642(identity)|ddbj/embl/genbank:BC002417(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:Q9UJA3 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-8756095|uniprotkb:B2RBG7|uniprotkb:D3DW08|uniprotkb:E7EQU7|uniprotkb:Q495R4|uniprotkb:Q495R6|uniprotkb:Q495R7|uniprotkb:Q86US4|uniprotkb:Q969I5|ensembl:ENSP00000368174|ensembl:ENSP00000478141 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm8_human(display_long)|uniprotkb:MCM8(gene name)|psi-mi:MCM8(display_short)|uniprotkb:C20orf154(gene name synonym)|uniprotkb:Minichromosome maintenance 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) refseq:XP_016883594.1|refseq:NP_115874.3|refseq:NP_877954.1|refseq:NP_001268449.1|refseq:NP_001268450.1|refseq:NP_001268451.1|ensembl:ENST00000378896(transcript)|ensembl:ENST00000610722(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|ensembl:ENSG00000125885(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007292"(female gamete generation)|go:"GO:0019899"(enzyme binding)|go:"GO:0032406"(MutLbeta complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0032408"(MutSbeta complex binding)|go:"GO:0036298"(recombinational interstrand cross-link repair)|go:"GO:0042555"(MCM complex)|go:"GO:0048232"(male gamete generation)|go:"GO:0050821"(protein stabilization)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0097362"(MCM8-MCM9 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR027417|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:Q9UJA3|rcsb pdb:6L0O|rcsb pdb:7DP3|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|uniprotkb:Q9UJA3(identity)|genbank_protein_gi:19923727(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:po4hzJ/+5JWxog5BnKAfHYKmE7w9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:Q13451 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:P33991 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N|uniprotkb:P33991(identity)|genbank_protein_gi:33469917(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:Q14566 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N|uniprotkb:Q14566(identity)|genbank_protein_gi:7427519(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:Q9NXL9 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-2804985|uniprotkb:Q8N5S5|uniprotkb:Q2KHJ0|uniprotkb:Q9HCV5|intact:EBI-28972951|uniprotkb:B4DR30|uniprotkb:B9DI77|ensembl:ENSP00000314505|ensembl:ENSP00000480469 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm9_human(display_long)|uniprotkb:C6orf61(gene name synonym)|uniprotkb:MCMDC1(gene name synonym)|uniprotkb:Mini-chromosome maintenance deficient domain-containing protein 1(gene name synonym)|uniprotkb:MCM9(gene name)|psi-mi:MCM9(display_short)|uniprotkb:Minichromosome maintenance 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) ensembl:ENST00000316068|ensembl:ENSP00000312870|ensembl:ENSP00000314505|ensembl:ENSP00000480469|refseq:NP_060166.2|refseq:NP_694987.1|ensembl:ENSG00000111877(gene)|ensembl:ENST00000316316(transcript)|ensembl:ENST00000619706(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007292"(female gamete generation)|go:"GO:0019899"(enzyme binding)|go:"GO:0032406"(MutLbeta complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0032408"(MutSbeta complex binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036298"(recombinational interstrand cross-link repair)|go:"GO:0042555"(MCM complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070716"(mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0097362"(MCM8-MCM9 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR027417|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|rcsb pdb:7DPD|go:"GO:0005524"(ATP binding)|uniprotkb:Q9NXL9(identity)|genbank_protein_gi:312284070(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:CZnc4GbTnlURdHlzMN+0T+VBljQ9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BTE3 uniprotkb:P33993 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394909|imex:IM-22301-1596 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9|uniprotkb:Q9BTE3(identity)|entrezgene/locuslink:79892(identity)|genbank_protein_gi:13376243(identity)|ddbj/embl/genbank:BC004183(identity) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N|uniprotkb:P33993(identity)|ddbj/embl/genbank:BC013375(identity)|entrezgene/locuslink:4176(identity)|genbank_protein_gi:33469968(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1, supplementary fig 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:4C5E5E7E71AD48AA|rigid:TUhVv5vYVHVxw79Rh4VpJFtCjSQ false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:Q9UDY4 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-356960|uniprotkb:Q13431|uniprotkb:B2R824|ensembl:ENSP00000359799 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:dnjb4_human(display_long)|uniprotkb:DNAJB4(gene name)|psi-mi:DNAJB4(display_short)|uniprotkb:DNAJW(gene name synonym)|uniprotkb:HLJ1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1 homolog(gene name synonym)|uniprotkb:Human liver DnaJ-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) refseq:NP_008965.2|refseq:NP_001304028.1|refseq:NP_001304029.1|refseq:NP_001304030.1|refseq:NP_001304031.1|refseq:NP_001304032.1|ensembl:ENSG00000162616(gene)|ensembl:ENST00000370763(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009408"(response to heat)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UDY4|uniprotkb:Q9UDY4(identity)|entrezgene/locuslink:11080(identity)|genbank_protein_gi:6631085(identity)|ddbj/embl/genbank:BC034721(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:gN0zBtJQiTN+YYSAtMk1mddNWLU9606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:O95816 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:O75190 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:P25685 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:O95817 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N|uniprotkb:O95817(identity)|entrezgene/locuslink:9531(identity)|genbank_protein_gi:14043024(identity)|ddbj/embl/genbank:BC006418(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15773 uniprotkb:P17066 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219 psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9394970|imex:IM-22301-1597 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695|uniprotkb:P17066(identity)|ddbj/embl/genbank:BC035665(identity)|entrezgene/locuslink:3310(identity)|genbank_protein_gi:34419635(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606 intact-crc:F8666183ABC4688F|rigid:/JUXLLEOCMttgoTZkXFs/R7dnrU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y266 uniprotkb:Q96JY0 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-9395015|uniprotkb:Q9UIW6|uniprotkb:Q5VZP8|uniprotkb:E9JVC3|uniprotkb:B4DY43|uniprotkb:Q49AP9|ensembl:ENSP00000356846 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:mael_human(display_long)|uniprotkb:MAEL(gene name)|psi-mi:MAEL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395024|imex:IM-22301-1598 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) refseq:NP_001273306.1|refseq:NP_001273307.1|refseq:NP_116247.1|ensembl:ENSG00000143194(gene)|ensembl:ENST00000367872(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001741"(XY body)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009566"(fertilization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030849"(autosome)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033391"(chromatoid body)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043186"(P granule)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0071547"(piP-body)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR024970|interpro:IPR036910|interpro:IPR039259|rcsb pdb:2CTO|reactome:R-HSA-5601884|uniprotkb:Q96JY0(identity)|genbank_protein_gi:14249590(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:f/ALD3bx83R8J7/sox1Vx+aWbps9606 intact-crc:FA061682A04E0AE9|rigid:/wkKiUSg18AsPx9fVyP2xe6Jtnc false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y266 uniprotkb:P31689 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-347834|ensembl:ENSP00000369127|uniprotkb:Q5T7Q0|uniprotkb:Q86TL9 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dnja1_human(display_long)|uniprotkb:DNAJA1(gene name)|psi-mi:DNAJA1(display_short)|uniprotkb:DNAJ2(gene name synonym)|uniprotkb:HDJ2(gene name synonym)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:HSPF4(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 4(gene name synonym)|uniprotkb:DnaJ protein homolog 2(gene name synonym)|uniprotkb:Human DnaJ protein 2(gene name synonym)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:HSDJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395024|imex:IM-22301-1598 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) ensembl:ENSG00000086061(gene)|ensembl:ENST00000330899(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009408"(response to heat)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:1901998"(toxin transport)|go:"GO:1903748"(negative regulation of establishment of protein localization to mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:P31689|rcsb pdb:2LO1|rcsb pdb:2M6Y|reactome:R-HSA-3371497|rcsb pdb:6E8M|refseq:NP_001530.1|uniprotkb:P31689(identity)|genbank_protein_gi:4504511(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:YEHeLHYaG2ON2gwuFfqt9Le1Drg9606 intact-crc:FA061682A04E0AE9|rigid:/wkKiUSg18AsPx9fVyP2xe6Jtnc false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y266 uniprotkb:P08708 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-358255|uniprotkb:B2R4U4|intact:EBI-8012092|intact:EBI-11603362|intact:MINT-8395037|uniprotkb:P0CW22|ensembl:ENSP00000483755|ensembl:ENSP00000498019 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:rs17_human(display_long)|uniprotkb:RPS17(gene name)|psi-mi:RPS17(display_short)|uniprotkb:Small ribosomal subunit protein eS17(gene name synonym)|uniprotkb:RPS17L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395024|imex:IM-22301-1598 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) refseq:NP_001012.1|ensembl:ENSG00000182774(gene)|ensembl:ENSG00000278229(gene)|ensembl:ENST00000617731(transcript)|ensembl:ENST00000647841(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|interpro:IPR001210(Ribosomal protein S17e)|interpro:IPR018273|interpro:IPR036401|mint:P08708|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|go:"GO:0034101"(erythrocyte homeostasis)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|rcsb pdb:6G4W|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOK|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|uniprotkb:P0CW22(identity)|genbank_protein_gi:312284072(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:st+xQCXdSObiy6cJD1cSx869V289606 intact-crc:FA061682A04E0AE9|rigid:/wkKiUSg18AsPx9fVyP2xe6Jtnc false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y266 uniprotkb:P25685 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395024|imex:IM-22301-1598 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding)|uniprotkb:P25685(identity)|genbank_protein_gi:5453690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:FA061682A04E0AE9|rigid:/wkKiUSg18AsPx9fVyP2xe6Jtnc false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y266 uniprotkb:O60884 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395024|imex:IM-22301-1598 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1|uniprotkb:Q9Y266(identity)|genbank_protein_gi:5729953(identity) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N|uniprotkb:O60884(identity)|entrezgene/locuslink:10294(identity)|genbank_protein_gi:5031741(identity)|ddbj/embl/genbank:BC013044(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/11/10 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 intact-crc:FA061682A04E0AE9|rigid:/wkKiUSg18AsPx9fVyP2xe6Jtnc false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:O43143 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1237044|uniprotkb:Q9NQT7|ensembl:ENSP00000336741 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dhx15_human(display_long)|uniprotkb:DHX15(gene name)|psi-mi:DHX15(display_short)|uniprotkb:DBP1(gene name synonym)|uniprotkb:DDX15(gene name synonym)|uniprotkb:DEAH box protein 15(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001349.2|dip:DIP-38211N|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR044756|mint:O43143|rcsb pdb:5XDR|rcsb pdb:6ID1|rcsb pdb:6SH6|rcsb pdb:6SH7|reactome:R-HSA-72163|ensembl:ENSG00000109606(gene)|ensembl:ENST00000336812(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016607"(nuclear speck)|go:"GO:0043279"(response to alkaloid)|uniprotkb:O43143(identity)|genbank_protein_gi:68509926(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:rOkQ5RG/3gc1/0Qcn5ANS6ImepY9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:O14579 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-711301|uniprotkb:O76097|ensembl:ENSP00000262812|uniprotkb:Q9UGP6|uniprotkb:Q6IBB8|uniprotkb:A6NKA3|uniprotkb:A6NE29 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:cope_human(display_long)|uniprotkb:COPE(gene name)|psi-mi:COPE(display_short)|uniprotkb:Epsilon-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_009194.2|ensembl:ENSG00000105669(gene)|ensembl:ENST00000262812(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0099612"(protein localization to axon)|interpro:IPR006822(Coatomer, epsilon subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:O14579|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_955474.1|refseq:NP_955476.1|uniprotkb:O14579(identity)|genbank_protein_gi:31542319(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:gjrR0x7iNHl/nEDtoZTjThB1dgs9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:P53621 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434|uniprotkb:P53621(identity)|genbank_protein_gi:148536853(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q9UBF2 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1045840|uniprotkb:A6NH74|uniprotkb:Q54AC3|uniprotkb:Q8WVW8|ensembl:ENSP00000402346|uniprotkb:Q2NLA0 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copg2_human(display_long)|uniprotkb:Gamma-2-coat protein(gene name synonym)|uniprotkb:COPG2(gene name)|psi-mi:COPG2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001276962.1|refseq:NP_036265.3|ensembl:ENSG00000158623(gene)|ensembl:ENST00000425248(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9UBF2|reactome:R-HSA-6807878|reactome:R-HSA-6811434|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|uniprotkb:Q9UBF2(identity)|genbank_protein_gi:109134349(identity)|entrezgene/locuslink:26958(identity)|ddbj/embl/genbank:BC017443(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:VEvct8z8lwNWbLs2GFPrKwk1GpE9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:P61923 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1049939|uniprotkb:Q549N6|uniprotkb:Q9Y3C3|uniprotkb:B4DDX8|uniprotkb:F8VS17|uniprotkb:F8VWL5|uniprotkb:B4DHZ0|ensembl:ENSP00000262061 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copz1_human(display_long)|uniprotkb:Zeta-1-coat protein(gene name synonym)|uniprotkb:COPZ1(gene name)|psi-mi:COPZ1(display_short)|uniprotkb:COPZ(gene name synonym)|uniprotkb:CGI-120(orf name)|uniprotkb:HSPC181(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_057141.1|refseq:NP_001258663.1|refseq:NP_001258664.1|refseq:NP_001258665.1|ensembl:ENST00000262061(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|interpro:IPR000804(Clathrin adaptor, sigma subunit/coatomer, zeta subunit)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR039652|rcsb pdb:2HF6|rcsb pdb:5MC7|reactome:R-HSA-6807878|reactome:R-HSA-6811434|ensembl:ENSG00000111481(gene)|dip:DIP-29873N|uniprotkb:P61923(identity)|genbank_protein_gi:414144870(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:1/IgMqSz7ThLUzNhR4ARUq+Gr6I9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:B7Z6S9 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-9395055 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:b7z6s9_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) interpro:IPR033452|interpro:IPR033453|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|refseq:NP_001005741.1|refseq:NP_001005742.1|refseq:NP_001165282.1|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016757"(glycosyltransferase activity)|uniprotkb:B7Z6S9(identity)|genbank_protein_gi:284807150(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:rgpGrr+jQVTQt1c65PSARasSJ9Y9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:P48444 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N|uniprotkb:P48444(identity)|genbank_protein_gi:11863154(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q96M86 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-9395069|uniprotkb:Q8NAA2|uniprotkb:Q9NSZ9|uniprotkb:Q2NKK8|uniprotkb:Q8TEE6|uniprotkb:Q6UWI9|ensembl:ENSP00000254579 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dnhd1_human(display_long)|uniprotkb:DNHD1(gene name)|psi-mi:DNHD1(display_short)|uniprotkb:C11orf47(gene name synonym)|uniprotkb:CCDC35(gene name synonym)|uniprotkb:DHCD1(gene name synonym)|uniprotkb:DNHD1L(gene name synonym)|uniprotkb:Dynein heavy chain domain 1-like protein(gene name synonym)|uniprotkb:Protein CCDC35(gene name synonym)|uniprotkb:UNQ5781/PRO12970(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_653267.2|refseq:NP_775860.3|ensembl:ENSG00000179532(gene)|ensembl:ENST00000254579(transcript)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030286"(dynein complex)|go:"GO:0036156"(inner dynein arm)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026983|interpro:IPR027417|interpro:IPR035699|interpro:IPR041228|interpro:IPR041466|interpro:IPR042222|interpro:IPR042228|uniprotkb:Q96M86(identity)|genbank_protein_gi:222144249(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:vJHz1jhrsrf1fG07PNX/XEw0uug9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q15303 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N|uniprotkb:Q15303(identity)|genbank_protein_gi:110825958(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:B6LYhMaoSj5IT6caAnj1n262+H49606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q92620 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1043041|uniprotkb:O75212|uniprotkb:Q96HN7|ensembl:ENSP00000268482|uniprotkb:D3DWS7|uniprotkb:B4DVG8 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:prp16_human(display_long)|uniprotkb:DHX38(gene name)|psi-mi:DHX38(display_short)|uniprotkb:DDX38(gene name synonym)|uniprotkb:KIAA0224(gene name synonym)|uniprotkb:PRP16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DHX38(gene name synonym)|uniprotkb:DEAH box protein 38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000140829(gene)|ensembl:ENST00000268482(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016020"(membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q92620|rcsb pdb:5YZG|rcsb pdb:6ZYM|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_054722.2|refseq:XP_011521786.1|refseq:XP_011521787.1|uniprotkb:Q92620(identity)|ddbj/embl/genbank:BC004235(identity)|genbank_protein_gi:17999539(identity)|entrezgene/locuslink:9785(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:miHZNGhDUIz9imwhlPz2tIsCNLs9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q9Y678 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N|uniprotkb:Q9Y678(identity)|entrezgene/locuslink:22820(identity)|ddbj/embl/genbank:BC066650(identity)|genbank_protein_gi:11559929(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:A3KMH1 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-308657|uniprotkb:Q5JTP6|uniprotkb:Q5VW08|uniprotkb:Q7Z6I9|uniprotkb:Q86YC9|uniprotkb:Q8N3E4|uniprotkb:O60310|ensembl:ENSP00000368612 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:vwa8_human(display_long)|uniprotkb:VWA8(gene name)|psi-mi:VWA8(display_short)|uniprotkb:KIAA0564(gene name synonym)|uniprotkb:PEX7-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000102763(gene)|ensembl:ENST00000379310(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|refseq:NP_001009814.1|refseq:NP_055873.1|refseq:XP_016875963.1|uniprotkb:A3KMH1(identity)|genbank_protein_gi:57863271(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:IOalBj68cHFF4BsViQ+eeXQZiRY9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:P35606 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-1056534|uniprotkb:B4DZI8|intact:EBI-11019844|ensembl:ENSP00000329419 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copb2_human(display_long)|uniprotkb:COPB2(gene name)|psi-mi:COPB2(display_short)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_004757.1|ensembl:ENSG00000184432(gene)|ensembl:ENST00000333188(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:P35606|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:XP_016863001.1|dip:DIP-27603N|uniprotkb:P35606(identity)|genbank_protein_gi:4758032(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:zkd7lOeV+OvHglnAJg6cXoMhgbg9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q9H6R0 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-2512405|ensembl:ENSP00000225296|uniprotkb:Q4G149|uniprotkb:B4DHF9|uniprotkb:Q5CZ73|uniprotkb:Q9H5M9 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dhx33_human(display_long)|uniprotkb:DHX33(gene name)|psi-mi:DHX33(display_short)|uniprotkb:DDX33(gene name synonym)|uniprotkb:DEAH box protein 33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000005100(gene)|ensembl:ENST00000225296(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q9H6R0|refseq:NP_001186628.1|refseq:NP_064547.2|refseq:XP_016880366.1|uniprotkb:Q9H6R0(identity)|genbank_protein_gi:20336302(identity)|ddbj/embl/genbank:BC042040(identity)|entrezgene/locuslink:56919(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:jR/BdCPb1fZgJxOWaxNRfqo0AvQ9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:O95436 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-9395082|uniprotkb:Q9P0V7|uniprotkb:Q8N2K2|uniprotkb:A5PL17|uniprotkb:Q8WYA9|ensembl:ENSP00000371483 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:npt2b_human(display_long)|uniprotkb:SLC34A2(gene name)|psi-mi:SLC34A2(display_short)|uniprotkb:"Na(+)-dependent phosphate cotransporter 2B"(gene name synonym)|uniprotkb:NaPi3b(gene name synonym)|uniprotkb:Sodium/phosphate cotransporter 2B(gene name synonym)|uniprotkb:Solute carrier family 34 member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSP00000371483|ensembl:ENST00000503434|ensembl:ENSP00000423021|ensembl:ENST00000504570|ensembl:ENSP00000425501|ensembl:ENST00000645788|ensembl:ENSP00000494094|refseq:NP_001171470.1|refseq:NP_006415.2|refseq:NP_001171469.1|ensembl:ENSG00000157765(gene)|ensembl:ENST00000382051(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005436"("sodium:phosphate symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006817"(phosphate ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0031982"(vesicle)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0044341"(sodium-dependent phosphate transport)|interpro:IPR003841(Na+/Pi-cotransporter)|interpro:IPR029852|reactome:R-HSA-427589|reactome:R-HSA-5619045|reactome:R-HSA-5683826|reactome:R-HSA-5687583|uniprotkb:O95436(identity)|genbank_protein_gi:110611906(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:VcTGXDaQM9K2l7uefaaPxZVCcUE9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q14562 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-2511477|ensembl:ENSP00000262415|ensembl:ENSP00000496923 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dhx8_human(display_long)|uniprotkb:DHX8(gene name)|psi-mi:DHX8(display_short)|uniprotkb:DDX8(gene name synonym)|uniprotkb:DEAH box protein 8(gene name synonym)|uniprotkb:RNA helicase HRH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) mint:Q14562|rcsb pdb:2EQS|rcsb pdb:3I4U|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:6HYS|rcsb pdb:6HYT|rcsb pdb:6HYU|rcsb pdb:6ICZ|rcsb pdb:6QDV|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0042802"(identical protein binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR003029(S1, RNA binding)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR022967|interpro:IPR027417|interpro:IPR044762|ensembl:ENSG00000067596(gene)|ensembl:ENST00000262415(transcript)|ensembl:ENST00000650571(transcript)|go:"GO:0000390"(spliceosomal complex disassembly)|refseq:NP_004932.1|refseq:NP_001289552.1|uniprotkb:Q14562(identity)|entrezgene/locuslink:1659(identity)|ddbj/embl/genbank:BC044586(identity)|genbank_protein_gi:4826690(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:ZUmh+KApFNV5NKCq6dizDgnw/Dw9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:A2VDF0 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-9395061|uniprotkb:Q6ZPD2|uniprotkb:A1L300|uniprotkb:Q5VWY2|uniprotkb:Q5VWY3|ensembl:ENSP00000278025 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:fucm_human(display_long)|uniprotkb:FUOM(gene name)|psi-mi:FUOM(display_short)|uniprotkb:C10orf125(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001288756.1|refseq:NP_001288757.1|refseq:NP_001091953.1|refseq:NP_940874.2|ensembl:ENSG00000148803(gene)|ensembl:ENST00000278025(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0016857"(racemase and epimerase activity, acting on carbohydrates and derivatives)|go:"GO:0036065"(fucosylation)|go:"GO:0036373"(L-fucose mutarotase activity)|go:"GO:0042806"(fucose binding)|interpro:IPR007721(RbsD or FucU transport)|interpro:IPR023750|reactome:R-HSA-6787639|uniprotkb:A2VDF0(identity)|genbank_protein_gi:148596947(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:2gTFAcSa5WHULfL1KsuAie/iXHY9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:O60231 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-311446|uniprotkb:O60322|uniprotkb:Q969X7|uniprotkb:Q96QC1|uniprotkb:Q5JP45|ensembl:ENSP00000365625|ensembl:ENSP00000373071|ensembl:ENSP00000389862|ensembl:ENSP00000390938|ensembl:ENSP00000393958|ensembl:ENSP00000396193|ensembl:ENSP00000408956 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dhx16_human(display_long)|uniprotkb:DHX16(gene name)|psi-mi:DHX16(display_short)|uniprotkb:DBP2(gene name synonym)|uniprotkb:DDX16(gene name synonym)|uniprotkb:KIAA0577(gene name synonym)|uniprotkb:DEAH-box protein 16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase #3(gene name synonym)|uniprotkb:PRP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001157711.1|refseq:NP_003578.2|ensembl:ENSG00000204560(gene)|ensembl:ENSG00000206486(gene)|ensembl:ENSG00000226171(gene)|ensembl:ENSG00000231377(gene)|ensembl:ENSG00000233049(gene)|ensembl:ENSG00000233418(gene)|ensembl:ENSG00000233561(gene)|ensembl:ENST00000376442(transcript)|ensembl:ENST00000383577(transcript)|ensembl:ENST00000417308(transcript)|ensembl:ENST00000421095(transcript)|ensembl:ENST00000424672(transcript)|ensembl:ENST00000451456(transcript)|ensembl:ENST00000458094(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF7|rcsb pdb:7DVQ|reactome:R-HSA-72163|uniprotkb:O60231(identity)|genbank_protein_gi:255982614(identity)|entrezgene/locuslink:8449(identity)|ddbj/embl/genbank:BC008825(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:sYCQp3qc9+wukR7aCf2qen2dgdU9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:Q8IX18 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-2514301|ensembl:ENSP00000251241|uniprotkb:B3KTJ5|uniprotkb:Q5JPH4|uniprotkb:Q8WY53|uniprotkb:Q8TC86|uniprotkb:Q9BXM1|uniprotkb:Q9H6M9|uniprotkb:C9JR60 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:dhx40_human(display_long)|uniprotkb:DHX40(gene name)|psi-mi:DHX40(display_short)|uniprotkb:DDX40(gene name synonym)|uniprotkb:DEAH box protein 40(gene name synonym)|uniprotkb:Protein PAD(gene name synonym)|uniprotkb:ARG147(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) ensembl:ENSG00000108406(gene)|ensembl:ENST00000251241(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_001159773.1|refseq:NP_078888.4|uniprotkb:Q8IX18(identity)|ddbj/embl/genbank:BC024187(identity)|genbank_protein_gi:261878478(identity)|entrezgene/locuslink:79665(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:jOdFhOZTjeXlSYf6zzKi/EiizXY9606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RS6 uniprotkb:P53618 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 intact:EBI-359063|uniprotkb:Q6GTT7|uniprotkb:Q9NTK2|uniprotkb:Q9UNW7|uniprotkb:D3DQX0|ensembl:ENSP00000249923|ensembl:ENSP00000397873 psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:copb_human(display_long)|uniprotkb:COPB1(gene name)|psi-mi:COPB1(display_short)|uniprotkb:COPB(gene name synonym)|uniprotkb:MSTP026(orf name)|uniprotkb:Beta-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395058|imex:IM-22301-1599 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1|uniprotkb:Q96RS6(identity) refseq:NP_001137533.1|refseq:NP_001137534.1|refseq:NP_057535.1|ensembl:ENSG00000129083(gene)|ensembl:ENST00000249923(transcript)|ensembl:ENST00000439561(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:P53618|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-265N|uniprotkb:P53618(identity)|genbank_protein_gi:221316630(identity)|entrezgene/locuslink:1315(identity)|ddbj/embl/genbank:BC037280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 rogid:EBxh2JlK3Z8HxbZXa3fG0nOgYu89606 intact-crc:7EA8706648F0ECCB|rigid:exnuOBaB5znNZshvZrlGKJfNETw false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q6NSI4 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-8634209|ensembl:ENSP00000361628|uniprotkb:Q9H7W5|uniprotkb:Q6PHY5|uniprotkb:Q6PII9|intact:MINT-8162145|uniprotkb:Q9NWA6|uniprotkb:Q5JQS1|uniprotkb:Q4G0L7|uniprotkb:H7BY89|uniprotkb:Q5JRF9|uniprotkb:Q6PJU8 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:radx_human(display_long)|uniprotkb:RADX(gene name)|psi-mi:RADX(display_short)|uniprotkb:CXorf57(gene name synonym)|uniprotkb:RPA-related and RAD51-antagonist, X-chromosome(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) ensembl:ENSG00000147231(gene)|ensembl:ENST00000372548(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005657"(replication fork)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR040893|refseq:NP_060485.4|refseq:NP_001171711.1|uniprotkb:Q6NSI4(identity)|entrezgene/locuslink:55086(identity)|genbank_protein_gi:193804923(identity)|ddbj/embl/genbank:BC070110(identity) psi-mi:"MI:0469"(intact) - comment:mint figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:pUlTaH5Wq19LDuJp7qGlWFpa0q09606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q99523 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N|uniprotkb:Q99523(identity)|genbank_protein_gi:17149834(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:h/+2jen/dw+5leVis906F7iBs/A9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q86V97 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2514778|ensembl:ENSP00000368799|uniprotkb:Q96MP6|uniprotkb:Q8NDM5|uniprotkb:Q5T6Y8|uniprotkb:Q8N8L0 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:kbtb6_human(display_long)|uniprotkb:KBTBD6(gene name)|psi-mi:KBTBD6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) ensembl:ENSG00000165572(gene)|ensembl:ENST00000379485(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4XC2|refseq:NP_690867.3|uniprotkb:Q86V97(identity)|genbank_protein_gi:45333883(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:iMugkQiayHqkx3aiExLs32a5Bv49606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q15393 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-346977|uniprotkb:Q6NTI8|uniprotkb:Q96GC0|uniprotkb:Q9BPY2|uniprotkb:Q9UFX7|uniprotkb:Q9UJ29|ensembl:ENSP00000305790 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:sf3b3_human(display_long)|uniprotkb:SF3B3(gene name)|psi-mi:SF3B3(display_short)|uniprotkb:KIAA0017(gene name synonym)|uniprotkb:SAP130(gene name synonym)|uniprotkb:Spliceosome-associated protein 130(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 130 kDa subunit(gene name synonym)|uniprotkb:STAF130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_036558.3|dip:DIP-28152N|ensembl:ENSG00000189091(gene)|ensembl:ENST00000302516(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|rcsb pdb:5O9Z|go:"GO:0005654"(nucleoplasm)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|rcsb pdb:5ZYA|rcsb pdb:6AH0|go:"GO:0030620"(U2 snRNA binding)|rcsb pdb:6AHD|rcsb pdb:6EN4|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR036322|mint:Q15393|rcsb pdb:5IFE|uniprotkb:Q15393(identity)|genbank_protein_gi:54112121(identity)|entrezgene/locuslink:23450(identity)|ddbj/embl/genbank:BC000463(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:gnCSXjZ/bwNXair6kyQUKoKIwbM9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q6P5Z2 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-1384335|uniprotkb:Q9UM03|ensembl:ENSP00000291906 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:pkn3_human(display_long)|uniprotkb:PKNBETA(gene name synonym)|uniprotkb:Protein kinase PKN-beta(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 3(gene name synonym)|uniprotkb:PKN3(gene name)|psi-mi:PKN3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_037487.2|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000160447(gene)|ensembl:ENST00000291906(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|uniprotkb:Q6P5Z2(identity)|genbank_protein_gi:40254851(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:VkdWW9BW24I/9AWyh6wP5u1MRCA9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q96C01 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-373319|uniprotkb:Q96SS3|ensembl:ENSP00000037869 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:f136a_human(display_long)|uniprotkb:FAM136A(gene name)|psi-mi:FAM136A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_116211.2|ensembl:ENSG00000035141(gene)|ensembl:ENST00000037869(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR008560(Protein of unknown function DUF842, eukaryotic)|uniprotkb:Q96C01(identity)|genbank_protein_gi:189491675(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:i9TSWgN6JC8fuAcFrlTU3IKBDHE9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q9P2J3 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N|uniprotkb:Q9P2J3(identity)|genbank_protein_gi:24308181(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q8NBE8 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2512246|ensembl:ENSP00000272797|ensembl:ENSP00000376419|uniprotkb:Q8N9B9|uniprotkb:Q96FT8 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:klh23_human(display_long)|uniprotkb:KLHL23(gene name)|psi-mi:KLHL23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) ensembl:ENSG00000213160(gene)|ensembl:ENST00000272797(transcript)|ensembl:ENST00000392647(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001186219.1|refseq:NP_653312.2|uniprotkb:Q8NBE8(identity)|genbank_protein_gi:313151204(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:KHjH26i26qZE1hlbLvVU+qbSJHk9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q04837 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201|uniprotkb:Q04837(identity)|genbank_protein_gi:374671775(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:P51610 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N|uniprotkb:P51610(identity)|ddbj/embl/genbank:BC063435(identity)|genbank_protein_gi:98986457(identity)|entrezgene/locuslink:3054(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q86X55 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP)|uniprotkb:Q86X55(identity)|genbank_protein_gi:40288288(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IVD9 uniprotkb:Q13451 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395191|imex:IM-22301-1600 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N|uniprotkb:Q8IVD9(identity)|genbank_protein_gi:122939165(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:EF03D1EBE60D62F1|rigid:0rHCDLjzY75vPWDk41aXrxEAzYk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43175 uniprotkb:Q9Y6I3 intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08 intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18 psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym) psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395254|imex:IM-22301-1601 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347|uniprotkb:O43175(identity)|genbank_protein_gi:23308577(identity) go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1|uniprotkb:Q9Y6I3(identity)|genbank_protein_gi:194248095(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606 rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606 intact-crc:95460506948B8D5C|rigid:FFgtt54T7jKtljnKEkIkD4dg0nE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43175 uniprotkb:Q03395 intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08 intact:EBI-9395257|uniprotkb:B2R978|ensembl:ENSP00000278833 psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym) psi-mi:rom1_human(display_long)|uniprotkb:ROM1(gene name)|psi-mi:ROM1(display_short)|uniprotkb:TSPAN23(gene name synonym)|uniprotkb:Tetraspanin-23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395254|imex:IM-22301-1601 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347|uniprotkb:O43175(identity)|genbank_protein_gi:23308577(identity) refseq:NP_000318.1|ensembl:ENSG00000149489(gene)|ensembl:ENST00000278833(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007601"(visual perception)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:1903546"(protein localization to photoreceptor outer segment)|interpro:IPR000830(Peripherin/rom-1)|interpro:IPR008952(Tetraspanin)|interpro:IPR018498|interpro:IPR018499|interpro:IPR042026|uniprotkb:Q03395(identity)|genbank_protein_gi:4506575(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606 rogid:pvsLXveNWj0yKasAZdyBW1ejDbk9606 intact-crc:95460506948B8D5C|rigid:FFgtt54T7jKtljnKEkIkD4dg0nE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43175 uniprotkb:Q15811 intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08 intact:EBI-602041|uniprotkb:B4DTM2|uniprotkb:O95216|uniprotkb:Q9UET5|uniprotkb:Q9UK60|uniprotkb:Q9UNK1|uniprotkb:Q9UNK2|uniprotkb:Q9UQ92|uniprotkb:Q1ED40|uniprotkb:Q0PW97|uniprotkb:E7ERJ1|uniprotkb:Q14BD3|uniprotkb:Q20BK3|intact:EBI-11029034|uniprotkb:A7Y322|uniprotkb:A8CTX8|uniprotkb:A8CTY3|uniprotkb:A8CTY7|uniprotkb:A8D7D0|uniprotkb:A8DCP3|uniprotkb:E9PE44|uniprotkb:E9PG01|uniprotkb:E9PHV2|uniprotkb:Q0PW94|uniprotkb:Q0PW95|intact:EBI-28971797|ensembl:ENSP00000370719 psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym) psi-mi:itsn1_human(display_long)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3D1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395254|imex:IM-22301-1601 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347|uniprotkb:O43175(identity)|genbank_protein_gi:23308577(identity) ensembl:ENST00000381291|ensembl:ENSP00000370691|ensembl:ENSP00000370719|ensembl:ENST00000399338|ensembl:ENSP00000382275|ensembl:ENST00000399349|ensembl:ENSP00000382286|ensembl:ENSP00000382289|ensembl:ENST00000399353|ensembl:ENSP00000382290|ensembl:ENST00000399367|ensembl:ENSP00000382301|ensembl:ENST00000399352|refseq:NP_001001132.1|refseq:NP_003015.2|refseq:XP_011527994.1|refseq:XP_011527995.1|refseq:NP_001317938.1|refseq:NP_001317939.1|refseq:NP_001317940.1|refseq:NP_001317941.1|refseq:XP_016883917.1|refseq:XP_016883921.1|refseq:XP_016883922.1|refseq:XP_016883929.1|dip:DIP-33609N|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381318(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0098793"(presynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q15811|rcsb pdb:1KI1|rcsb pdb:2KGR|rcsb pdb:2KHN|rcsb pdb:3FIA|rcsb pdb:3QBV|rcsb pdb:4IIM|rcsb pdb:5HZI|rcsb pdb:5HZJ|rcsb pdb:5HZK|rcsb pdb:6GBU|rcsb pdb:6H5T|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-416482|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013408|uniprotkb:Q15811(identity)|genbank_protein_gi:47717123(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606 rogid:gYC3xiyk4dbnCXhZ8Rzn3rzafyU9606 intact-crc:95460506948B8D5C|rigid:FFgtt54T7jKtljnKEkIkD4dg0nE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q08752 uniprotkb:Q8IXQ4 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 intact:EBI-9395283|uniprotkb:Q9P0W6|uniprotkb:Q9H2R0|uniprotkb:Q05BX8|uniprotkb:A8K8X8|uniprotkb:Q5T3Z3|uniprotkb:Q5T3Z5|uniprotkb:Q05D87|uniprotkb:Q9C0F9|ensembl:ENSP00000368447|ensembl:ENSP00000432500 psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:gpam1_human(display_long)|uniprotkb:GPALPP1(gene name)|psi-mi:GPALPP1(display_short)|uniprotkb:KIAA1704(gene name synonym)|uniprotkb:LSR7(gene name synonym)|uniprotkb:Lipopolysaccharide-specific response protein 7(gene name synonym)|uniprotkb:AD029(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395280|imex:IM-22301-1602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) refseq:NP_001303880.1|refseq:NP_001303881.1|refseq:NP_061029.2|refseq:XP_005266501.1|ensembl:ENSG00000133114(gene)|ensembl:ENST00000379151(transcript)|ensembl:ENST00000497558(transcript)|interpro:IPR022226|uniprotkb:Q8IXQ4(identity)|genbank_protein_gi:33354279(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 rogid:TQ8dfhN5p676eTsTi/uud2iuWvc9606 intact-crc:704B7DAC4204303D|rigid:7jeqa23zOfSyyS6cX2q8EL/C0u0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q08752 uniprotkb:Q16543 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395280|imex:IM-22301-1602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:704B7DAC4204303D|rigid:7jeqa23zOfSyyS6cX2q8EL/C0u0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q08752 uniprotkb:O95433 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395280|imex:IM-22301-1602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:704B7DAC4204303D|rigid:7jeqa23zOfSyyS6cX2q8EL/C0u0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q08752 uniprotkb:Q15185 intact:EBI-716596|uniprotkb:B2R9V2|ensembl:ENSP00000303754 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:ppid_human(display_long)|uniprotkb:Cyclophilin-40(gene name synonym)|uniprotkb:Cyclophilin-related protein(gene name synonym)|uniprotkb:PPID(gene name)|psi-mi:PPID(display_short)|uniprotkb:CYP40(gene name synonym)|uniprotkb:CYPD(gene name synonym)|uniprotkb:Rotamase D(gene name synonym)|uniprotkb:40 kDa peptidyl-prolyl cis-trans isomerase(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395280|imex:IM-22301-1602 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005029.1|ensembl:ENSG00000171497(gene)|ensembl:ENST00000307720(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015031"(protein transport)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0019076"(viral release from host cell)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR029000|reactome:R-HSA-8939211|interpro:IPR011990(Tetratricopeptide-like helical)|dip:DIP-34893N|uniprotkb:Q08752(identity)|genbank_protein_gi:4826932(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:Vw7y4LTw7d9HE3txHGqBM0NEY5Q9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:704B7DAC4204303D|rigid:7jeqa23zOfSyyS6cX2q8EL/C0u0 false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:P08238 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:Q15185 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0|uniprotkb:Q15185(identity)|genbank_protein_gi:23308579(identity)|entrezgene/locuslink:10728(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:Q86SX1 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-9392873 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:K9JA46 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-9392866 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:Q16543 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:Q9UHD1 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P53041 uniprotkb:O95433 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395319|imex:IM-22301-1603 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N|uniprotkb:P53041(identity)|genbank_protein_gi:324021716(identity)|ddbj/embl/genbank:BC001970(identity)|entrezgene/locuslink:5536(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:CAD2EB89C6F6CA5B|rigid:BS+/cmLk5/5WF95M5Rcs4JD+uao false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2C9 uniprotkb:P16615 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395364|imex:IM-22301-1604 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity) refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N|uniprotkb:P16615(identity)|entrezgene/locuslink:488(identity)|genbank_protein_gi:24638454(identity)|ddbj/embl/genbank:BC035588(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 intact-crc:F33DC18DC8E64D05|rigid:+XJZUadTCIQo9uxpcnmxqKuUuMU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2C9 uniprotkb:P20020 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395364|imex:IM-22301-1604 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity) refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|uniprotkb:P20020(identity)|genbank_protein_gi:48255945(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:kCpUNLYDF38hciXj32D8rXbXULg9606 intact-crc:F33DC18DC8E64D05|rigid:+XJZUadTCIQo9uxpcnmxqKuUuMU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2C9 uniprotkb:Q9NVI1 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1013291|uniprotkb:Q96JN1|uniprotkb:Q96ST0|uniprotkb:Q9BT96|uniprotkb:A5YMH4|uniprotkb:A6NJZ0|uniprotkb:A4ZVE4|ensembl:ENSP00000310842 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:fanci_human(display_long)|uniprotkb:FANCI(gene name)|psi-mi:FANCI(display_short)|uniprotkb:KIAA1794(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395364|imex:IM-22301-1604 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity) refseq:XP_011520058.1|refseq:XP_011520059.1|refseq:XP_011520066.1|refseq:NP_001106849.1|refseq:NP_060663.2|dip:DIP-29381N|ensembl:ENSG00000140525(gene)|ensembl:ENST00000310775(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0070182"(DNA polymerase binding)|interpro:IPR026171|interpro:IPR029305|interpro:IPR029308|interpro:IPR029310|interpro:IPR029312|interpro:IPR029313|interpro:IPR029314|interpro:IPR029315|mint:Q9NVI1|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|reactome:R-HSA-6783310|reactome:R-HSA-6796648|uniprotkb:Q9NVI1(identity)|genbank_protein_gi:164607124(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:yJJMHIBOVPDIQcCBJ19DGitg3VA9606 intact-crc:F33DC18DC8E64D05|rigid:+XJZUadTCIQo9uxpcnmxqKuUuMU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2C9 uniprotkb:Q9Y6E2 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-1051021|uniprotkb:Q3B779|uniprotkb:Q9H3F7|uniprotkb:A4D123|uniprotkb:Q96JW5|ensembl:ENSP00000258761|ensembl:ENSP00000397249 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:bzw2_human(display_long)|uniprotkb:BZW2(gene name)|psi-mi:BZW2(display_short)|uniprotkb:HSPC028(orf name)|uniprotkb:MSTP017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395364|imex:IM-22301-1604 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity) refseq:NP_001153239.1|refseq:NP_054757.1|ensembl:ENSG00000136261(gene)|ensembl:ENST00000258761(transcript)|ensembl:ENST00000433922(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043510|refseq:XP_006715769.1|refseq:XP_006715770.1|refseq:XP_006715771.1|uniprotkb:Q9Y6E2(identity)|genbank_protein_gi:229577398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:+z22Ykb6e3IM9zk51m6tjuhiEcU9606 intact-crc:F33DC18DC8E64D05|rigid:+XJZUadTCIQo9uxpcnmxqKuUuMU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8K2C9 uniprotkb:P40855 intact:EBI-8329978|uniprotkb:Q6PGH3|intact:MINT-4110360|uniprotkb:Q8BGM8|intact:MINT-1858563|uniprotkb:O09003|ensembl:ENSMUSP00000044955 intact:EBI-594747|uniprotkb:Q8NI97|intact:EBI-981972|uniprotkb:Q5QNY4|uniprotkb:D3DVE7|ensembl:ENSP00000357051 psi-mi:hacd3_mouse(display_long)|uniprotkb:Hacd3(gene name)|psi-mi:Hacd3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:Ptplad1(gene name synonym) psi-mi:pex19_human(display_long)|uniprotkb:PEX19(gene name)|psi-mi:PEX19(display_short)|uniprotkb:HK33(gene name synonym)|uniprotkb:PXF(gene name synonym)|uniprotkb:OK/SW-cl.22(orf name)|uniprotkb:Peroxin-19(gene name synonym)|uniprotkb:Peroxisomal farnesylated protein(gene name synonym)|uniprotkb:33 kDa housekeeping protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395364|imex:IM-22301-1604 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067320.2|ensembl:ENSMUSG00000033629(gene)|ensembl:ENSMUST00000036615(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q8K2C9|reactome:R-MMU-75876|uniprotkb:Q8K2C9(identity)|entrezgene/locuslink:57874(identity) refseq:NP_001180573.1|refseq:NP_002848.1|dip:DIP-24172N|ensembl:ENSG00000162735(gene)|ensembl:ENST00000368072(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016557"(peroxisome membrane biogenesis)|go:"GO:0016559"(peroxisome fission)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0036105"(peroxisome membrane class-1 targeting sequence binding)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0072663"(establishment of protein localization to peroxisome)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900131"(negative regulation of lipid binding)|interpro:IPR006708(Pex19 protein)|interpro:IPR038322|mint:P40855|rcsb pdb:2W85|rcsb pdb:2WL8|rcsb pdb:3AJB|rcsb pdb:3MK4|rcsb pdb:5LNF|reactome:R-HSA-1369062|reactome:R-HSA-9603798|uniprotkb:P40855(identity)|genbank_protein_gi:302370946(identity)|entrezgene/locuslink:5824(identity)|ddbj/embl/genbank:BC000496(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:FKbwiVjK68zpdfQhFiAiprsWszE10090 rogid:yNnX2hPPJ7miGaz2Req0qFn0L189606 intact-crc:F33DC18DC8E64D05|rigid:+XJZUadTCIQo9uxpcnmxqKuUuMU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9Y2Z0 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9Y230 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N|uniprotkb:Q9Y230(identity)|genbank_protein_gi:5730023(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:P60891 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-749195|uniprotkb:P09329|uniprotkb:B2R6T7|uniprotkb:B1ALA8|uniprotkb:B4DNL6|uniprotkb:D3DUX6|ensembl:ENSP00000361512 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:prps1_human(display_long)|uniprotkb:Phosphoribosyl pyrophosphate synthase I(gene name synonym)|uniprotkb:PRPS1(gene name)|psi-mi:PRPS1(display_short)|uniprotkb:PPRibP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_001191331.1|refseq:NP_002755.1|ensembl:ENSG00000147224(gene)|ensembl:ENST00000372435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002189"(ribose phosphate diphosphokinase complex)|go:"GO:0004749"(ribose phosphate diphosphokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006221"(pyrimidine nucleotide biosynthetic process)|go:"GO:0007399"(nervous system development)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0009156"(ribonucleoside monophosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0034418"(urate biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046101"(hypoxanthine biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR000842(Phosphoribosyl pyrophosphate synthetase, conserved site)|interpro:IPR005946(Phosphoribosyl pyrophosphokinase)|go:"GO:0006144"(purine nucleobase metabolic process)|interpro:IPR029057|interpro:IPR029099|interpro:IPR037515|rcsb pdb:2H06|rcsb pdb:2H07|rcsb pdb:2H08|rcsb pdb:2HCR|rcsb pdb:3EFH|rcsb pdb:3S5J|rcsb pdb:4F8E|rcsb pdb:4LYG|rcsb pdb:4LZN|rcsb pdb:4LZO|rcsb pdb:4M0P|rcsb pdb:4M0U|reactome:R-HSA-73843|dip:DIP-61999N|uniprotkb:P60891(identity)|genbank_protein_gi:4506127(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:+Hih2M7JLTsjEglauBlPj182h9M9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q96MX6 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-2434101|uniprotkb:Q96CR6|ensembl:ENSP00000295121 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:daa10_human(display_long)|uniprotkb:DNAAF10(gene name)|psi-mi:DNAAF10(display_short)|uniprotkb:WD repeat-containing protein 92(gene name synonym)|uniprotkb:WD repeat-containing protein Monad(gene name synonym)|uniprotkb:WDR92(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_612467.1|refseq:NP_001243405.1|ensembl:ENSG00000243667(gene)|ensembl:ENST00000295121(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070286"(axonemal dynein complex assembly)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q96MX6|rcsb pdb:3I2N|uniprotkb:Q96MX6(identity)|entrezgene/locuslink:116143(identity)|genbank_protein_gi:24308444(identity)|ddbj/embl/genbank:BC014022(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:mMEdSK0cmIF+8Bayok/snQBKYMg9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9UHV9 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N|uniprotkb:Q9UHV9(identity)|entrezgene/locuslink:5202(identity)|genbank_protein_gi:12408675(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9HB71 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9NUG6 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-307050|uniprotkb:Q96GP3|uniprotkb:Q9BUW8|ensembl:ENSP00000202017|uniprotkb:B2R511 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:pdrg1_human(display_long)|uniprotkb:PDRG1(gene name)|psi-mi:PDRG1(display_short)|uniprotkb:C20orf126(gene name synonym)|uniprotkb:PDRG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) ensembl:ENSG00000088356(gene)|ensembl:ENST00000202017(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR030482|mint:Q9NUG6|refseq:NP_110442.1|dip:DIP-27568N|uniprotkb:Q9NUG6(identity)|entrezgene/locuslink:81572(identity)|genbank_protein_gi:18079254(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:Q6qLyEyyEFBqxYhfx2lYg05nixQ9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9BVM2 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-749988|uniprotkb:Q8N5R1|uniprotkb:A8K289|uniprotkb:Q6QNL3|uniprotkb:Q9UFY6|ensembl:ENSP00000359170 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:dpcd_human(display_long)|uniprotkb:DPCD(gene name)|psi-mi:DPCD(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_056263.1|ensembl:ENSG00000166171(gene)|ensembl:ENST00000370151(transcript)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0060972"(left/right pattern formation)|interpro:IPR026224|go:"GO:0021678"(third ventricle development)|uniprotkb:Q9BVM2(identity)|entrezgene/locuslink:25911(identity)|ddbj/embl/genbank:BC001082(identity)|genbank_protein_gi:39930355(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:k1AnQBTvPufE9zRF8lMAxFhGtug9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:P19388 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-395189|uniprotkb:O43380|uniprotkb:Q6PIH5|uniprotkb:Q9BT06|uniprotkb:B2R6L4|uniprotkb:D6W5Y1|ensembl:ENSP00000464739|ensembl:ENSP00000478303|ensembl:ENSP00000485021 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:rpab1_human(display_long)|uniprotkb:POLR2E(gene name)|psi-mi:POLR2E(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit E(gene name synonym)|uniprotkb:RPB5 homolog(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 23 kDa polypeptide(gene name synonym)|uniprotkb:XAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_002686.2|ensembl:ENSG00000099817(gene)|ensembl:ENST00000586746(transcript)|ensembl:ENST00000612655(transcript)|ensembl:ENST00000615234(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR000783(RNA polymerase, subunit H/Rpb5 C-terminal)|interpro:IPR005571(RNA polymerase, Rpb5, N-terminal)|interpro:IPR014381(DNA-directed RNA polymerase, RPB5 subunit)|interpro:IPR020608|interpro:IPR020609|interpro:IPR035913|interpro:IPR036710|interpro:IPR039531|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|mint:P19388|rcsb pdb:5IY6|rcsb pdb:5IY7|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-167246|dip:DIP-56N|uniprotkb:P19388(identity)|genbank_protein_gi:14589951(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:BIVesx7KODhdpcgjhU6CghhXNQE9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:O94966 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1|uniprotkb:O94966(identity)|genbank_protein_gi:312596871(identity)|ddbj/embl/genbank:BC146752(identity)|entrezgene/locuslink:10869(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9UHR6 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-2557592|uniprotkb:Q8IUV0|uniprotkb:Q3SY14|ensembl:ENSP00000308548 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:znhi2_human(display_long)|uniprotkb:ZNHIT2(gene name)|psi-mi:ZNHIT2(display_short)|uniprotkb:Protein FON(gene name synonym)|uniprotkb:C11orf5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_055020.1|ensembl:ENSG00000174276(gene)|ensembl:ENST00000310597(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR007529(Zinc finger, HIT-type)|interpro:IPR039646|rcsb pdb:1X4S|uniprotkb:Q9UHR6(identity)|genbank_protein_gi:7656936(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:kzpAH9lDvvANjOhTrTcuUtQwkEU9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9NWS0 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357318|intact:EBI-748162|uniprotkb:B4DGN7|uniprotkb:B4E2X7|uniprotkb:Q9BVL0|ensembl:ENSP00000262265|ensembl:ENSP00000470445 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:pihd1_human(display_long)|uniprotkb:PIH1D1(gene name)|psi-mi:PIH1D1(display_short)|uniprotkb:NOP17(gene name synonym)|uniprotkb:Nucleolar protein 17 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_060386.1|ensembl:ENSG00000104872(gene)|ensembl:ENST00000262265(transcript)|ensembl:ENST00000596049(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042393"(histone binding)|go:"GO:0048254"(snoRNA localization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0097255"(R2TP complex)|go:"GO:1900110"(negative regulation of histone H3-K9 dimethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902661"(positive regulation of glucose mediated signaling pathway)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR012981(Nop17p)|interpro:IPR041442|mint:Q9NWS0|rcsb pdb:4PSF|rcsb pdb:4PSI|rcsb pdb:6GXZ|rcsb pdb:7AVC|uniprotkb:Q9NWS0(identity)|genbank_protein_gi:8923598(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:lugKS0BlzZYpMZn/7LFHODnFk0Q9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:O94763 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357067|uniprotkb:A8K805|uniprotkb:Q9UNU3|intact:EBI-2683009|uniprotkb:H7BY42|uniprotkb:Q8TC23|ensembl:ENSP00000376097 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:rmp_human(display_long)|uniprotkb:URI1(gene name)|psi-mi:URI1(display_short)|uniprotkb:C19orf2(gene name synonym)|uniprotkb:NNX3(gene name synonym)|uniprotkb:PPP1R19(gene name synonym)|uniprotkb:Protein NNX3(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 19(gene name synonym)|uniprotkb:RMP(gene name synonym)|uniprotkb:RNA polymerase II subunit 5-mediating protein(gene name synonym)|uniprotkb:URI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_003787.2|ensembl:ENSG00000105176(gene)|refseq:NP_001239570.1|ensembl:ENST00000392271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009615"(response to virus)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0019212"(phosphatase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:O94763|uniprotkb:O94763(identity)|ddbj/embl/genbank:BC067259(identity)|genbank_protein_gi:19924159(identity)|entrezgene/locuslink:8725(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:izqLgjD5/WAkdmUp7K8hIQ+cGxE9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9UBK9 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-357355|ensembl:ENSP00000327797|uniprotkb:B2R561|uniprotkb:Q5JZG3|uniprotkb:Q9Y6E5|uniprotkb:A0A0C4DFR8 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:uxt_human(display_long)|uniprotkb:UXT(gene name)|psi-mi:UXT(display_short)|uniprotkb:HSPC024(orf name)|uniprotkb:Ubiquitously expressed transcript protein(gene name synonym)|uniprotkb:Androgen receptor trapped clone 27 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) ensembl:ENSG00000126756(gene)|ensembl:ENST00000333119(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|interpro:IPR003994(Prefoldin related, ubiquitously expressed transcript)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|mint:Q9UBK9|reactome:R-HSA-8953750|go:"GO:0003714"(transcription corepressor activity)|refseq:NP_004173.1|refseq:NP_705582.1|uniprotkb:Q9UBK9(identity)|entrezgene/locuslink:8409(identity)|genbank_protein_gi:24041018(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:XhE14Q7CfwVXxJ4fTiRQTm3Idvk9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:Q9Y265 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N|uniprotkb:Q9Y265(identity)|genbank_protein_gi:4506753(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H6T3 uniprotkb:O43175 intact:EBI-356928|uniprotkb:Q6PHR5|uniprotkb:B4DRW9|ensembl:ENSP00000005386 intact:EBI-350495|uniprotkb:Q5SZU3|uniprotkb:Q9BQ01|ensembl:ENSP00000493175|ensembl:ENSP00000493382|uniprotkb:B2RD08 psi-mi:rpap3_human(display_long)|uniprotkb:RPAP3(gene name)|psi-mi:RPAP3(display_short) psi-mi:sera_human(display_long)|uniprotkb:PHGDH(gene name)|psi-mi:PHGDH(display_short)|uniprotkb:PGDH3(gene name synonym)|uniprotkb:2-oxoglutarate reductase(gene name synonym)|uniprotkb:Malate dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395397|imex:IM-22301-1605 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001139547.1|refseq:NP_001139548.1|refseq:NP_078880.2|dip:DIP-47508N|ensembl:ENSG00000005175(gene)|ensembl:ENST00000005386(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0097255"(R2TP complex)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR025986|mint:Q9H6T3|rcsb pdb:4CGV|rcsb pdb:4CGW|rcsb pdb:6EZ4|rcsb pdb:6FD7|rcsb pdb:6FDP|rcsb pdb:6FDT|rcsb pdb:6FM8|rcsb pdb:6FO1|rcsb pdb:6GXZ|rcsb pdb:6ZBK|uniprotkb:Q9H6T3(identity)|genbank_protein_gi:225735591(identity)|ddbj/embl/genbank:BC056415(identity)|entrezgene/locuslink:79657(identity) refseq:NP_006614.2|go:"GO:0030060"(L-malate dehydrogenase activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070314"(G1 to G0 transition)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR006236(D-3-phosphoglycerate dehydrogenase)|interpro:IPR029009|interpro:IPR029752|interpro:IPR029753|interpro:IPR036291|mint:O43175|rcsb pdb:2G76|rcsb pdb:5N53|rcsb pdb:5N6C|rcsb pdb:5NZO|rcsb pdb:5NZP|rcsb pdb:5NZQ|rcsb pdb:5OFM|rcsb pdb:5OFV|ensembl:ENSG00000092621(gene)|ensembl:ENST00000641023(transcript)|ensembl:ENST00000641597(transcript)|go:"GO:0004617"(phosphoglycerate dehydrogenase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006566"(threonine metabolic process)|go:"GO:0007420"(brain development)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009448"(gamma-aminobutyric acid metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0021510"(spinal cord development)|go:"GO:0021782"(glial cell development)|go:"GO:0021915"(neural tube development)|rcsb pdb:5OFW|rcsb pdb:6CWA|rcsb pdb:6PLF|rcsb pdb:6PLG|rcsb pdb:6RIH|rcsb pdb:6RJ2|rcsb pdb:6RJ3|rcsb pdb:6RJ5|rcsb pdb:6RJ6|rcsb pdb:7CVP|reactome:R-HSA-977347|uniprotkb:O43175(identity)|genbank_protein_gi:23308577(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:pN6/ClY+oonHFRAFtpcGeZ/OTEQ9606 rogid:uzg4EVysd7/zLXBurqwTCFMvqiA9606 intact-crc:EFE55329FA86D684|rigid:K2aq8qE4hzPk6Em8tEPezdtq0LY false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:Q9NXW2 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-358818|uniprotkb:Q9H6H0|uniprotkb:B7Z7I3|ensembl:ENSP00000403313 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:djb12_human(display_long)|uniprotkb:DNAJB12(gene name)|psi-mi:DNAJB12(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_001002762.2|refseq:NP_060096.3|ensembl:ENSG00000148719(gene)|ensembl:ENST00000444643(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034622"|go:"GO:0036503"(ERAD pathway)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0071218"(cellular response to misfolded protein)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR015399(Protein of unknown function DUF1977, DnaJ-like)|interpro:IPR018253|interpro:IPR036869|mint:Q9NXW2|rcsb pdb:2CTP|go:"GO:0005789"(endoplasmic reticulum membrane)|uniprotkb:Q9NXW2(identity)|genbank_protein_gi:194306640(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:kt+aES6+wgXo7o1UhFt4E5w9wTs9606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:P11441 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523|uniprotkb:P11441(identity)|genbank_protein_gi:7657667(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:O95816 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:O43681 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-2515857|ensembl:ENSP00000349887|ensembl:ENSP00000466379|uniprotkb:Q53FC6|uniprotkb:A8K740|uniprotkb:A6NHP8|uniprotkb:Q92849|intact:EBI-2818109 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:get3_human(display_long)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARSA(gene name synonym)|uniprotkb:ASNA1(gene name synonym)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins factor 3, ATPase(gene name synonym)|uniprotkb:TRC40(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 40 kDa ATPase subunit(gene name synonym)|uniprotkb:hARSA-I(gene name synonym)|uniprotkb:hASNA-I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) ensembl:ENSG00000198356(gene)|ensembl:ENST00000357332(transcript)|ensembl:ENST00000591090(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0015105"(arsenite transmembrane transporter activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0043529"(GET complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|mint:O43681|rcsb pdb:6SO5|reactome:R-HSA-9609523|refseq:NP_004308.2|uniprotkb:O43681(identity)|genbank_protein_gi:50428938(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:j2jKZb3MH8Bd3hnoQhDO6bjbyxI9606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:O95757 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-358652|uniprotkb:Q4W5M5|uniprotkb:Q8IWA2|uniprotkb:A2ICT2|ensembl:ENSP00000296464|ensembl:ENSP00000422482 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:hs74l_human(display_long)|uniprotkb:HSPA4L(gene name)|psi-mi:HSPA4L(display_short)|uniprotkb:APG1(gene name synonym)|uniprotkb:OSP94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)|uniprotkb:Heat-shock protein family A member 4-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:O95757|reactome:R-HSA-3371453|refseq:NP_055093.2|refseq:NP_001304310.1|refseq:NP_001304311.1|refseq:NP_001304312.1|go:"GO:0005634"(nucleus)|ensembl:ENSG00000164070(gene)|ensembl:ENST00000296464(transcript)|ensembl:ENST00000508776(transcript)|go:"GO:0005524"(ATP binding)|uniprotkb:O95757(identity)|genbank_protein_gi:31541941(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:6ZoMlI4t4A4u4YsQgrlcwAqjpi49606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:Q7L5D6 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2|uniprotkb:Q7L5D6(identity)|ddbj/embl/genbank:BC003550(identity)|entrezgene/locuslink:51608(identity)|genbank_protein_gi:38570062(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43765 uniprotkb:P46379 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395484|imex:IM-22301-1606 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1|uniprotkb:O43765(identity)|entrezgene/locuslink:6449(identity)|ddbj/embl/genbank:BC000390(identity) dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86|uniprotkb:P46379(identity)|genbank_protein_gi:149158692(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/10/11 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:60C1CC16A287010E|rigid:igxrrAWTAN9Vapha30CpTBCdmQI false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:O75190 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:Q86SX1 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9392873 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:P08238 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:Q8IWD4 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-3387963|uniprotkb:A8K0F1|uniprotkb:Q6ICA7|uniprotkb:Q8N278|uniprotkb:B7Z2V1|uniprotkb:B7Z860|ensembl:ENSP00000249064 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:cc117_human(display_long)|uniprotkb:CCDC117(gene name)|psi-mi:CCDC117(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) refseq:NP_001271192.1|refseq:NP_001271193.1|refseq:NP_001271194.1|refseq:NP_775781.1|ensembl:ENSG00000159873(gene)|interpro:IPR031630|ensembl:ENST00000249064(transcript)|uniprotkb:Q8IWD4(identity)|ddbj/embl/genbank:BC053874(identity)|genbank_protein_gi:27735133(identity)|entrezgene/locuslink:150275(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:fZemg0/JfMK6Y4x/filFiP3YKmw9606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:O95816 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:Q15773 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P31948 uniprotkb:K9JA46 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 intact:EBI-9392866 psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395526|imex:IM-22301-1607 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N|uniprotkb:P31948(identity)|genbank_protein_gi:5803181(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:64782C7E2E139709|rigid:v/qs9Tu8J6C9jmVB5y2d2E0zTMM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:P08107 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487|uniprotkb:P08107(identity)|genbank_protein_gi:167466173(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:Q6IA69 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-748610|uniprotkb:Q86SN2|uniprotkb:Q9HA25|uniprotkb:Q9NVM8|uniprotkb:B3KUU4|ensembl:ENSP00000326424 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:nade_human(display_long)|uniprotkb:"NAD(+) synthase [glutamine-hydrolyzing]"(gene name synonym)|uniprotkb:"NAD(+) synthetase"(gene name synonym)|uniprotkb:NADSYN1(gene name)|psi-mi:NADSYN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_060631.2|ensembl:ENSG00000172890(gene)|ensembl:ENST00000319023(transcript)|go:"GO:0003952"("NAD+ synthase (glutamine-hydrolyzing) activity")|go:"GO:0004359"(glutaminase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009435"(NAD biosynthetic process)|go:"GO:0034627"('de novo' NAD biosynthetic process)|interpro:IPR003010(Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase)|interpro:IPR003694(NAD+ synthase)|interpro:IPR014445("Glutamine-dependent NAD(+) synthetase, GAT region")|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR022310|interpro:IPR036526|rcsb pdb:6OFB|reactome:R-HSA-196807|uniprotkb:Q6IA69(identity)|genbank_protein_gi:41393551(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:6DRDevbKgH67/vzPqnrzCsQG47g9606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:P34931 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-354912|uniprotkb:O75634|uniprotkb:Q2HXR3|uniprotkb:Q8NE72|uniprotkb:A6NNB0|uniprotkb:Q96QC9|uniprotkb:Q9UQM1|uniprotkb:B0UXW8|ensembl:ENSP00000364805|ensembl:ENSP00000372881|ensembl:ENSP00000396486|ensembl:ENSP00000408347 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:hs71l_human(display_long)|uniprotkb:HSPA1L(gene name)|psi-mi:HSPA1L(display_short)|uniprotkb:Heat shock 70 kDa protein 1-Hom(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_005518.3|ensembl:ENSG00000204390(gene)|ensembl:ENSG00000206383(gene)|ensembl:ENSG00000234258(gene)|ensembl:ENSG00000236251(gene)|ensembl:ENST00000375654(transcript)|ensembl:ENST00000383390(transcript)|ensembl:ENST00000417601(transcript)|ensembl:ENST00000456772(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0072562"(blood microparticle)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P34931|rcsb pdb:3GDQ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|uniprotkb:P34931(identity)|genbank_protein_gi:124256496(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:KS02DcMpD2sxSF36hUjKiSdYi4c9606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:O95816 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:Q15773 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-1051875|intact:EBI-9357094|ensembl:ENSP00000203630|ensembl:ENSP00000403941|ensembl:ENSP00000446317 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:mlf2_human(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:MLF2(gene name)|psi-mi:MLF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_005430.1|ensembl:ENSG00000089693(gene)|ensembl:ENST00000203630(transcript)|ensembl:ENST00000435120(transcript)|ensembl:ENST00000539187(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|interpro:IPR019376|mint:Q15773|uniprotkb:Q15773(identity)|ddbj/embl/genbank:BC000898(identity)|genbank_protein_gi:4885487(identity)|entrezgene/locuslink:8079(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:Ix7bMALTVwBVty3IAuUn+PP/0BU9606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:P61088 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638|uniprotkb:P61088(identity)|genbank_protein_gi:4507793(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:P54652 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-356991|uniprotkb:Q15508|uniprotkb:Q53XM3|uniprotkb:Q9UE78|ensembl:ENSP00000247207|ensembl:ENSP00000378199 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:hsp72_human(display_long)|uniprotkb:HSPA2(gene name)|psi-mi:HSPA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_068814.2|ensembl:ENSG00000126803(gene)|ensembl:ENST00000247207(transcript)|ensembl:ENST00000394709(transcript)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0036128"(CatSper complex)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0048156"(tau protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051861"(glycolipid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0072562"(blood microparticle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P54652|rcsb pdb:3I33|rcsb pdb:4FSV|rcsb pdb:5FPD|rcsb pdb:5FPE|rcsb pdb:5FPM|rcsb pdb:5FPN|reactome:R-HSA-1221632|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|uniprotkb:P54652(identity)|ddbj/embl/genbank:BC036107(identity)|entrezgene/locuslink:3306(identity)|genbank_protein_gi:13676857(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:U+fdNfdxAWBQxDwSx0plk/iIBpM9606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:O95757 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-358652|uniprotkb:Q4W5M5|uniprotkb:Q8IWA2|uniprotkb:A2ICT2|ensembl:ENSP00000296464|ensembl:ENSP00000422482 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:hs74l_human(display_long)|uniprotkb:HSPA4L(gene name)|psi-mi:HSPA4L(display_short)|uniprotkb:APG1(gene name synonym)|uniprotkb:OSP94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)|uniprotkb:Heat-shock protein family A member 4-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:O95757|reactome:R-HSA-3371453|refseq:NP_055093.2|refseq:NP_001304310.1|refseq:NP_001304311.1|refseq:NP_001304312.1|go:"GO:0005634"(nucleus)|ensembl:ENSG00000164070(gene)|ensembl:ENST00000296464(transcript)|ensembl:ENST00000508776(transcript)|go:"GO:0005524"(ATP binding)|uniprotkb:O95757(identity)|genbank_protein_gi:31541941(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:6ZoMlI4t4A4u4YsQgrlcwAqjpi49606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:Q9NUQ3 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-3445062|uniprotkb:Q9P0X1|uniprotkb:Q2KQ75|uniprotkb:Q5JNZ7|ensembl:ENSP00000369465 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:txlng_human(display_long)|uniprotkb:TXLNG(gene name)|psi-mi:TXLNG(display_short)|uniprotkb:CXorf15(gene name synonym)|uniprotkb:ELRG(gene name synonym)|uniprotkb:LSR5(gene name synonym)|uniprotkb:Environmental lipopolysaccharide-responding gene protein(gene name synonym)|uniprotkb:Factor inhibiting ATF4-mediated transcription(gene name synonym)|uniprotkb:Lipopolysaccharide-specific response protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_001162154.1|refseq:NP_060830.2|ensembl:ENSG00000086712(gene)|ensembl:ENST00000380122(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR026183|uniprotkb:Q9NUQ3(identity)|genbank_protein_gi:281182404(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:0doUc9vE4XTNMsGyGAIHLzzx1W89606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UNE7 uniprotkb:O75190 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395575|imex:IM-22301-1608 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168|uniprotkb:Q9UNE7(identity)|ddbj/embl/genbank:BC007545(identity)|genbank_protein_gi:56181387(identity)|entrezgene/locuslink:10273(identity) refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|uniprotkb:O75190(identity)|ddbj/embl/genbank:BC002446(identity)|entrezgene/locuslink:10049(identity)|genbank_protein_gi:17388799(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606 intact-crc:AE617C793301D3AA|rigid:nMzJOqpXlyHucdfWhWjpKvah4Rk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q8IW35 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-1566210|uniprotkb:Q8NA71|uniprotkb:Q9H5T9|uniprotkb:B5MDY8|intact:EBI-2560935|ensembl:ENSP00000342510 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:cep97_human(display_long)|uniprotkb:LRRIQ2(gene name synonym)|uniprotkb:Leucine-rich repeat and IQ domain-containing protein 2(gene name synonym)|uniprotkb:CEP97(gene name)|psi-mi:CEP97(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) refseq:NP_078824.2|refseq:NP_001290330.1|ensembl:ENSG00000182504(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0030030"(cell projection organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q8IW35|reactome:R-HSA-5620912|reactome:R-HSA-9013424|ensembl:ENST00000341893(transcript)|uniprotkb:Q8IW35(identity)|genbank_protein_gi:31377705(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:Gz4rQbzgNiEg1X01O7YWz4TmfQA9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q02790 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N|uniprotkb:Q02790(identity)|entrezgene/locuslink:2288(identity)|genbank_protein_gi:4503729(identity)|ddbj/embl/genbank:BC001786(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q13309 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168|uniprotkb:Q13309(identity)|genbank_protein_gi:16306595(identity)|ddbj/embl/genbank:BC001441(identity)|entrezgene/locuslink:6502(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:O00170 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-704197|uniprotkb:Q2M3Q2|uniprotkb:Q99606|uniprotkb:A0SZW3|uniprotkb:A0SZW4|uniprotkb:A0SZW5|uniprotkb:A0SZW6|ensembl:ENSP00000279146 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:aip_human(display_long)|uniprotkb:Aryl-hydrocarbon receptor-interacting protein(gene name synonym)|uniprotkb:Immunophilin homolog ARA9(gene name synonym)|uniprotkb:HBV X-associated protein 2(gene name synonym)|uniprotkb:AIP(gene name)|psi-mi:AIP(display_short)|uniprotkb:XAP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) refseq:NP_003968.3|refseq:NP_001289888.1|refseq:NP_001289889.1|dip:DIP-34068N|ensembl:ENSG00000110711(gene)|ensembl:ENST00000279146(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0036004"(GAF domain binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051344"(negative regulation of cyclic-nucleotide phosphodiesterase activity)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031208|interpro:IPR039663|mint:O00170|rcsb pdb:2LKN|rcsb pdb:4AIF|rcsb pdb:4APO|reactome:R-HSA-8937144|reactome:R-HSA-8950505|uniprotkb:O00170(identity)|genbank_protein_gi:201860300(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:uCcvOG+bNnmT2zzm58nXhAzKbWo9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q9H4P4 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-2130266|uniprotkb:B2RBT8|uniprotkb:O75598|intact:EBI-2563208|intact:EBI-11576203|uniprotkb:A6NFW0|ensembl:ENSP00000342755|ensembl:ENSP00000447303|ensembl:ENSP00000484671 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:rnf41_human(display_long)|uniprotkb:RNF41(gene name)|psi-mi:RNF41(display_short)|uniprotkb:FLRF(gene name synonym)|uniprotkb:NRDP1(gene name synonym)|uniprotkb:RING finger protein 41(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NRDP1(gene name synonym)|uniprotkb:SBBI03(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) refseq:XP_011536036.1|refseq:XP_011536037.1|refseq:NP_001229755.1|refseq:NP_005776.1|refseq:NP_919340.1|refseq:NP_919339.1|refseq:XP_005268618.1|ensembl:ENSG00000181852(gene)|ensembl:ENST00000345093(transcript)|ensembl:ENST00000552656(transcript)|ensembl:ENST00000615206(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015036(USP8 interacting)|interpro:IPR017907|interpro:IPR037255|rcsb pdb:2FZP|rcsb pdb:2GWF|reactome:R-HSA-1358803|reactome:R-HSA-983168|uniprotkb:Q9H4P4(identity)|genbank_protein_gi:338827618(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:jthVZwxUECSdqeJ2jZQ5UL28kDY9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q13451 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N|uniprotkb:Q13451(identity)|genbank_protein_gi:224809327(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q9HB71 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1|uniprotkb:Q9HB71(identity)|genbank_protein_gi:60218913(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q15404 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-1057132|uniprotkb:Q6FI17|uniprotkb:D3DRU3|uniprotkb:A8KA46|ensembl:ENSP00000339521|ensembl:ENSP00000367154 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:rsu1_human(display_long)|uniprotkb:RSU1(gene name)|psi-mi:RSU1(display_short)|uniprotkb:RSP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) refseq:NP_689937.2|refseq:NP_036557.1|ensembl:ENSG00000148484(gene)|ensembl:ENST00000345264(transcript)|ensembl:ENST00000377921(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT8|rcsb pdb:7LT9|reactome:R-HSA-446388|uniprotkb:Q15404(identity)|genbank_protein_gi:34577083(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:QZduUWmFxzAxRHmcdDbCQlm6tBQ9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2Z0 uniprotkb:Q9H9A6 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 intact:EBI-1043135|uniprotkb:Q9NXC1|uniprotkb:Q9BTR7|uniprotkb:Q9NSK1|ensembl:ENSP00000359990 psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:lrc40_human(display_long)|uniprotkb:LRRC40(gene name)|psi-mi:LRRC40(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395634|imex:IM-22301-1609 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N|uniprotkb:Q9Y2Z0(identity)|entrezgene/locuslink:10910(identity)|genbank_protein_gi:195963398(identity) ensembl:ENSG00000066557(gene)|ensembl:ENST00000370952(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|refseq:NP_060238.3|uniprotkb:Q9H9A6(identity)|ddbj/embl/genbank:BC008586(identity)|entrezgene/locuslink:55631(identity)|genbank_protein_gi:21361633(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 rogid:DxDqTX9DvC1eU/vjACu8pZLo+Qk9606 intact-crc:F9CFACF348CD552B|rigid:w5+vubwbhSfQ4DaooVJvIftD4Fk false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:Q71U36 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|uniprotkb:Q71U36(identity)|genbank_protein_gi:17986283(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:O95757 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-358652|uniprotkb:Q4W5M5|uniprotkb:Q8IWA2|uniprotkb:A2ICT2|ensembl:ENSP00000296464|ensembl:ENSP00000422482 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:hs74l_human(display_long)|uniprotkb:HSPA4L(gene name)|psi-mi:HSPA4L(display_short)|uniprotkb:APG1(gene name synonym)|uniprotkb:OSP94(gene name synonym)|uniprotkb:Osmotic stress protein 94(gene name synonym)|uniprotkb:Heat shock 70-related protein APG-1(gene name synonym)|uniprotkb:Heat-shock protein family A member 4-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042708|interpro:IPR043129|mint:O95757|reactome:R-HSA-3371453|refseq:NP_055093.2|refseq:NP_001304310.1|refseq:NP_001304311.1|refseq:NP_001304312.1|go:"GO:0005634"(nucleus)|ensembl:ENSG00000164070(gene)|ensembl:ENST00000296464(transcript)|ensembl:ENST00000508776(transcript)|go:"GO:0005524"(ATP binding)|uniprotkb:O95757(identity)|genbank_protein_gi:31541941(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:6ZoMlI4t4A4u4YsQgrlcwAqjpi49606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:O95816 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-355275|uniprotkb:Q08AS9|uniprotkb:Q6FID0|uniprotkb:B4DXE2|ensembl:ENSP00000359727|intact:EBI-11068407 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:bag2_human(display_long)|uniprotkb:BAG2(gene name)|psi-mi:BAG2(display_short)|uniprotkb:Bcl-2-associated athanogene 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) refseq:NP_004273.1|refseq:XP_011513301.1|refseq:XP_005249547.1|ensembl:ENSG00000112208(gene)|ensembl:ENST00000370693(transcript)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0019538"(protein metabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1901588"(dendritic microtubule)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR037689|mint:O95816|reactome:R-HSA-3371453|refseq:XP_011513300.1|uniprotkb:O95816(identity)|genbank_protein_gi:4757834(identity)|ddbj/embl/genbank:BC125039(identity)|entrezgene/locuslink:9532(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:nBGGBIQc/3P0mwp7N/XuTGLOrg89606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:Q9P0L0 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|uniprotkb:Q9P0L0(identity)|genbank_protein_gi:94721252(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:Q9H4P4 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-2130266|uniprotkb:B2RBT8|uniprotkb:O75598|intact:EBI-2563208|intact:EBI-11576203|uniprotkb:A6NFW0|ensembl:ENSP00000342755|ensembl:ENSP00000447303|ensembl:ENSP00000484671 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:rnf41_human(display_long)|uniprotkb:RNF41(gene name)|psi-mi:RNF41(display_short)|uniprotkb:FLRF(gene name synonym)|uniprotkb:NRDP1(gene name synonym)|uniprotkb:RING finger protein 41(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase NRDP1(gene name synonym)|uniprotkb:SBBI03(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) refseq:XP_011536036.1|refseq:XP_011536037.1|refseq:NP_001229755.1|refseq:NP_005776.1|refseq:NP_919340.1|refseq:NP_919339.1|refseq:XP_005268618.1|ensembl:ENSG00000181852(gene)|ensembl:ENST00000345093(transcript)|ensembl:ENST00000552656(transcript)|ensembl:ENST00000615206(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015036(USP8 interacting)|interpro:IPR017907|interpro:IPR037255|rcsb pdb:2FZP|rcsb pdb:2GWF|reactome:R-HSA-1358803|reactome:R-HSA-983168|uniprotkb:Q9H4P4(identity)|genbank_protein_gi:338827618(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:jthVZwxUECSdqeJ2jZQ5UL28kDY9606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q99614 uniprotkb:O95292 intact:EBI-742074|uniprotkb:Q9BVT3|uniprotkb:B2RCT2|uniprotkb:D3DQJ8|ensembl:ENSP00000231238|ensembl:ENSP00000429225|ensembl:ENSP00000507891 intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175 psi-mi:ttc1_human(display_long)|uniprotkb:TTC1(gene name)|psi-mi:TTC1(display_short)|uniprotkb:TPR1(gene name synonym) psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395686|imex:IM-22301-1610 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269429.1|refseq:NP_003305.1|ensembl:ENST00000231238(transcript)|ensembl:ENST00000522793(transcript)|ensembl:ENST00000682719(transcript)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|ensembl:ENSG00000113312(gene)|uniprotkb:Q99614(identity) refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N|uniprotkb:O95292(identity)|genbank_protein_gi:4759302(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/09/23 rogid:jpDASWCrto0zMhBm3Cj9aDQURm09606 rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606 intact-crc:7753AC412BB42395|rigid:x1AjFTcxVcQdAc5uVWsmoWjTyyM false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q9BTY7 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2|uniprotkb:P0CB43(identity)|genbank_protein_gi:113420249(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:O95433 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q9UHD1 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-2550959|ensembl:ENSP00000319255|ensembl:ENSP00000496744|uniprotkb:Q9H3D6|uniprotkb:Q8WVL9|uniprotkb:B2R6P8|uniprotkb:Q6IN49 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:chrd1_human(display_long)|uniprotkb:CHP1(gene name synonym)|uniprotkb:CHORD domain-containing protein 1(gene name synonym)|uniprotkb:CHORDC1(gene name)|psi-mi:CHORDC1(display_short)|uniprotkb:Protein morgana(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) ensembl:ENSG00000110172(gene)|ensembl:ENSG00000285023(gene)|ensembl:ENST00000320585(transcript)|ensembl:ENST00000646618(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0043531"(ADP binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:2000299"(negative regulation of Rho-dependent protein serine/threonine kinase activity)|interpro:IPR007051(CHORD)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039790|rcsb pdb:2YRT|go:"GO:1900034"(regulation of cellular response to heat)|refseq:NP_001137545.1|refseq:NP_036256.2|uniprotkb:Q9UHD1(identity)|genbank_protein_gi:221316566(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:hlLw4jieLbD+CRQ/Nav7CR+YlUY9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:P08238 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q9NZQ9 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-9393504|uniprotkb:Q5JR83|uniprotkb:Q8WVL3|uniprotkb:Q9UKH2|uniprotkb:B7Z6N9|ensembl:ENSP00000295314 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:tmod4_human(display_long)|uniprotkb:TMOD4(gene name)|psi-mi:TMOD4(display_short)|uniprotkb:Skeletal muscle tropomodulin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) refseq:XP_011507751.1|refseq:XP_016856578.1|refseq:NP_037485.2|ensembl:ENSG00000163157(gene)|ensembl:ENST00000295314(transcript)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051694"(pointed-end actin filament capping)|interpro:IPR004934(Tropomodulin)|interpro:IPR030129|interpro:IPR032675|reactome:R-HSA-390522|uniprotkb:Q9NZQ9(identity)|genbank_protein_gi:156415984(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:ZJGCNYqt6P1kqXDoSEjEhDwksd09606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q709F0 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-2880718|ensembl:ENSP00000264990|uniprotkb:Q8WUT6|uniprotkb:Q08AF0|uniprotkb:Q658Y2|uniprotkb:Q658N9|uniprotkb:Q6ZND2|uniprotkb:Q9H9R3 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:acd11_human(display_long)|uniprotkb:ACAD11(gene name)|psi-mi:ACAD11(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) ensembl:ENSG00000240303(gene)|ensembl:ENST00000264990(transcript)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR002575(Aminoglycoside phosphotransferase)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|interpro:IPR041726|mint:Q709F0|rcsb pdb:2WBI|reactome:R-HSA-77289|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|refseq:NP_115545.3|uniprotkb:Q709F0(identity)|genbank_protein_gi:38505218(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:Qknz1ZNcvX0q/3f5TuGQkJ6oHSk9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q86SX1 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-9392873 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q3B7T1 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-2870947|uniprotkb:B2RC65|uniprotkb:Q8IZ74|uniprotkb:Q3KR40|uniprotkb:Q9Y3W4|uniprotkb:Q5VZQ4|uniprotkb:Q4G190|ensembl:ENSP00000349244 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:edrf1_human(display_long)|uniprotkb:EDRF1(gene name)|psi-mi:EDRF1(display_short)|uniprotkb:C10orf137(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) refseq:NP_001189367.1|refseq:NP_056423.2|ensembl:ENSG00000107938(gene)|ensembl:ENST00000356792(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|uniprotkb:Q3B7T1(identity)|entrezgene/locuslink:26098(identity)|ddbj/embl/genbank:BC107479(identity)|genbank_protein_gi:31742484(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:VauF5uK1BOHW5dUr9V1XCzY9EPo9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:K9JA46 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-9392866 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95801 uniprotkb:Q16543 intact:EBI-1050890|uniprotkb:Q5TA96|uniprotkb:Q9H3I2|uniprotkb:Q53Y95|ensembl:ENSP00000360329 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:ttc4_human(display_long)|uniprotkb:TTC4(gene name)|psi-mi:TTC4(display_short)|uniprotkb:My044(orf name) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395720|imex:IM-22301-1611 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004614.3|ensembl:ENSG00000243725(gene)|ensembl:ENST00000371281(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044059|rcsb pdb:6HFO|uniprotkb:O95801(identity)|genbank_protein_gi:156627581(identity) refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|uniprotkb:Q16543(identity)|entrezgene/locuslink:11140(identity)|genbank_protein_gi:5901922(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2018/09/18 rogid:TUGm8TA6JeHZMsObPJECcOCiGA89606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:C90257B6DFADAAA5|rigid:N9ejF+HAbKZhxvrIy6Cjl7twPdU false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZRV2 uniprotkb:Q9H3U1 intact:EBI-2556538|intact:EBI-2558430|uniprotkb:Q8N4W0|uniprotkb:A0JLS2|intact:EBI-28968834|ensembl:ENSP00000373565|ensembl:ENSP00000478790 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:fa83h_human(display_long)|uniprotkb:FAM83H(gene name)|psi-mi:FAM83H(display_short) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395776|imex:IM-22301-1612 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_940890.3|ensembl:ENSP00000373565|ensembl:ENSP00000478790|ensembl:ENSG00000180921(gene)|ensembl:ENSG00000273889(gene)|ensembl:ENST00000388913(transcript)|ensembl:ENST00000612192(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:1990254"(keratin filament binding)|interpro:IPR012461(Protein of unknown function DUF1669)|go:"GO:0030335"(positive regulation of cell migration)|interpro:IPR041996|go:"GO:0031214"(biomineral tissue development)|mint:Q6ZRV2|go:"GO:0044380"(protein localization to cytoskeleton)|go:"GO:0019901"(protein kinase binding)|refseq:XP_005250946.1|uniprotkb:Q6ZRV2(identity)|genbank_protein_gi:157311635(identity) refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1|uniprotkb:Q9H3U1(identity)|ddbj/embl/genbank:BC037992(identity)|genbank_protein_gi:29725607(identity)|entrezgene/locuslink:55898(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CraAR+g1L497ZXCuetDTOHn8rUA9606 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 intact-crc:8E79F4FDBC85AF0A|rigid:rFIrxtaoTCFRAnDk1VFi1zMWdns false - flag tag:c-c - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IWX7 uniprotkb:O95433 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-448610|uniprotkb:Q9P060|uniprotkb:Q96IL6|uniprotkb:B2R9L2|uniprotkb:B4DUR9|ensembl:ENSP00000216479 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:ahsa1_human(display_long)|uniprotkb:HSPC322(orf name)|uniprotkb:p38(gene name synonym)|uniprotkb:AHSA1(gene name)|psi-mi:AHSA1(display_short)|uniprotkb:C14orf3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395791|imex:IM-22301-1613 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) refseq:NP_036243.1|refseq:NP_001308370.1|ensembl:ENSG00000100591(gene)|ensembl:ENST00000216479(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013538(Activator of Hsp90 ATPase homologue 1-like)|interpro:IPR015310(Activator of Hsp90 ATPase, N-terminal)|interpro:IPR023393|interpro:IPR036338|interpro:IPR039981|mint:O95433|rcsb pdb:1X53|rcsb pdb:7DMD|rcsb pdb:7DME|go:"GO:0051879"(Hsp90 protein binding)|uniprotkb:O95433(identity)|genbank_protein_gi:6912280(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:HUgJrOxubEHSPst5ZQNxSC38QvY9606 intact-crc:A8730B3170D27CFF|rigid:H24f97wTUCY2W3WdaoUvCgBVJjE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IWX7 uniprotkb:K9JA46 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-9392866 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:k9ja46_human(display_long)|uniprotkb:EL52(gene name)|psi-mi:EL52(display_short)|uniprotkb:HSP90AA1(gene name synonym)|uniprotkb:hCG_1814169(orf name)|uniprotkb:HEL-S-65p(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395791|imex:IM-22301-1613 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|refseq:NP_005339.3|interpro:IPR036890|interpro:IPR037196|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0009408"(response to heat)|go:"GO:0009409"(response to cold)|go:"GO:0042470"(melanosome)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:K9JA46(identity)|genbank_protein_gi:154146191(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:qfaAHww82iR1p0hvrJY5oavsNyA9606 intact-crc:A8730B3170D27CFF|rigid:H24f97wTUCY2W3WdaoUvCgBVJjE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IWX7 uniprotkb:Q86SX1 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-9392873 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:q86sx1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395791|imex:IM-22301-1613 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020575|refseq:NP_001017963.2|interpro:IPR036890|go:"GO:0005524"(ATP binding)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|uniprotkb:Q86SX1(identity)|genbank_protein_gi:153792590(identity)|entrezgene/locuslink:3320(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:6XGapVVRBrPzEz7iH/4u7v1uEIk9606 intact-crc:A8730B3170D27CFF|rigid:H24f97wTUCY2W3WdaoUvCgBVJjE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8IWX7 uniprotkb:P08238 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395791|imex:IM-22301-1613 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation)|uniprotkb:Q8IWX7(identity)|ddbj/embl/genbank:BC101063(identity)|entrezgene/locuslink:146862(identity) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N|uniprotkb:P08238(identity)|genbank_protein_gi:20149594(identity)|entrezgene/locuslink:3326(identity)|ddbj/embl/genbank:BC004928(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:A8730B3170D27CFF|rigid:H24f97wTUCY2W3WdaoUvCgBVJjE false flag tag:c-c - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95400 uniprotkb:Q3UJD6-2 intact:EBI-768015|uniprotkb:Q9ULP2|uniprotkb:B2RDX2|ensembl:ENSP00000304903|ensembl:ENSP00000456935 intact:EBI-9359023|ensembl:ENSMUSP00000082119 psi-mi:cd2b2_human(display_long)|uniprotkb:CD2BP2(gene name)|psi-mi:CD2BP2(display_short)|uniprotkb:KIAA1178(gene name synonym)|uniprotkb:U5 snRNP 52K protein(gene name synonym) psi-mi:q3ujd6-2(display_long)|uniprotkb:Usp19(gene name)|psi-mi:Usp19(display_short)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Kiaa0891(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9395821|imex:IM-22301-1614 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230575.1|refseq:NP_006101.1|ensembl:ENSG00000169217(gene)|ensembl:ENST00000305596(transcript)|ensembl:ENST00000569466(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR003169(GYF)|interpro:IPR035445|interpro:IPR039905|mint:O95400|rcsb pdb:1GYF|rcsb pdb:1L2Z|rcsb pdb:1SYX|rcsb pdb:4BWS|reactome:R-HSA-72163|uniprotkb:O95400(identity)|genbank_protein_gi:343887347(identity) intact:EBI-9507654(isoform-parent)|ensembl:ENSMUSG00000006676(gene)|ensembl:ENSMUST00000085044(transcript)|uniprotkb:Q3UJD6-2(identity)|entrezgene/locuslink:71472(identity)|refseq:NP_082080.3(identity) psi-mi:"MI:0469"(intact) - - figure legend:Supplementary table S1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:eE6hXTyt05DhzzofcS/QJmUsLEY9606 rogid:eUlEEfwL/t17gGnafwncbwkq58k10090 intact-crc:CB31A762E644A4E9|rigid:0y+k+L+K0y/opmkuEV/0uDAC1/0 false - flag tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95429 uniprotkb:Q9NPI6 intact:EBI-2949658|uniprotkb:O95818|uniprotkb:B4E217|ensembl:ENSP00000287322 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:bag4_human(display_long)|uniprotkb:BAG4(gene name)|psi-mi:BAG4(display_short)|uniprotkb:SODD(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 4(gene name synonym)|uniprotkb:Silencer of death domains(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-9395902|imex:IM-22301-1616 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004865.1|ensembl:ENSP00000287322|ensembl:ENST00000432471|ensembl:ENSP00000393298|refseq:NP_001191807.1|ensembl:ENSG00000156735(gene)|ensembl:ENST00000287322(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090367"(negative regulation of mRNA modification)|go:"GO:0097178"(ruffle assembly)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:2001145"(negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:1M62|rcsb pdb:1M7K|reactome:R-HSA-3371453|reactome:R-HSA-5655302|reactome:R-HSA-75893|reactome:R-HSA-8853336 ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N - - - figure legend:3F, supplementary fig 3G|comment:The colocalization is only visible when BAG4 is expressed in low levels.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/03/06 2018/09/18 rogid:JtjyLj1+bwjuch67AUn3C70D4cw9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 intact-crc:C7E838AD50FEECE5|rigid:wwAmNCMUXebUclGV58cip/HCveA false yellow fluorescent protein tag:n-n - - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0422"(immunostaining) uniprotkb:O75426 uniprotkb:Q8WVJ2 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-1052153|uniprotkb:B2R4V0|ensembl:ENSP00000304854 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:nudc2_human(display_long)|uniprotkb:NUDCD2(gene name)|psi-mi:NUDCD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396197|imex:IM-22301-1624 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1 refseq:NP_660309.1|ensembl:ENSG00000170584(gene)|ensembl:ENST00000302764(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037898|interpro:IPR037902|mint:Q8WVJ2|dip:DIP-59509N - - caution:This sequence has been withdrawn from Uniprot.|crc64:8A425EA4F6F321FD figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:FdZrJ9o9VNtTyoDpOC3FqBdqydg9606 intact-crc:D4CE5A38D6FE02A2|rigid:BHyKATl35CHWUZvv2QSISNIuuR0 false flag tag:c-c|sufficient binding region:91-580(IPR000408) ha tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75426 uniprotkb:P08238 intact:EBI-6425658|ensembl:ENSP00000241071|uniprotkb:B4DY42|uniprotkb:A4D2D4|uniprotkb:B4DX91|uniprotkb:Q9H0G1 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fbx24_human(display_long)|uniprotkb:FBXO24(gene name)|psi-mi:FBXO24(display_short)|uniprotkb:FBX24(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396197|imex:IM-22301-1624 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000106336(gene)|ensembl:ENST00000241071(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR036047|refseq:NP_001156971.1|refseq:NP_036304.2|refseq:NP_277041.1 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wZpO7cCahvhFIwrULHEAl9Z/6NE9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:D4CE5A38D6FE02A2|rigid:BHyKATl35CHWUZvv2QSISNIuuR0 false flag tag:c-c|sufficient binding region:91-580(IPR000408) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT8 uniprotkb:Q9Y266 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396187|imex:IM-22301-1623 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168 ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1 - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:D97B0C00303409AD|rigid:mRCaAzjJZt7wu+ZtKk85IYYMpiw false sufficient binding region:115-454(IPR017986)|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT8 uniprotkb:P08238 intact:EBI-914727|uniprotkb:Q4VXH2|uniprotkb:Q7Z4V6|uniprotkb:Q8WV51|uniprotkb:Q9HA09|uniprotkb:Q9UKA3|uniprotkb:B3KRL8|ensembl:ENSP00000476369|ensembl:ENSP00000507010|ensembl:ENSP00000508157 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fbxw2_human(display_long)|uniprotkb:FBXW2(gene name)|psi-mi:FBXW2(display_short)|uniprotkb:FBW2(gene name synonym)|uniprotkb:FWD2(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 2(gene name synonym)|uniprotkb:Protein MD6(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396187|imex:IM-22301-1623 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036296.2|refseq:XP_005251967.1|refseq:XP_016870104.1|dip:DIP-37972N|ensembl:ENSG00000119402(gene)|ensembl:ENST00000608872(transcript)|ensembl:ENST00000684001(transcript)|ensembl:ENST00000684047(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|interpro:IPR042627|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:SLs3xu8ssSvd7zsJ6gnpF/Is8ZE9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:D97B0C00303409AD|rigid:mRCaAzjJZt7wu+ZtKk85IYYMpiw false sufficient binding region:115-454(IPR017986)|flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08238 uniprotkb:Q8IWX7 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-9363363|uniprotkb:Q495Q9|uniprotkb:Q495Q8|ensembl:ENSP00000268876 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:un45b_human(display_long)|uniprotkb:UNC45B(gene name)|psi-mi:UNC45B(display_short)|uniprotkb:CMYA4(gene name synonym)|uniprotkb:SMUNC45(gene name synonym)|uniprotkb:UNC45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396171|imex:IM-22301-1621 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N refseq:NP_001295210.1|refseq:XP_016879723.1|refseq:NP_001028748.1|refseq:NP_001253981.1|refseq:NP_775259.1|ensembl:ENSG00000141161(gene)|ensembl:ENST00000268876(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|go:"GO:0030154"(cell differentiation) - - - figure legend:Supplementary fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:3/IuHDYBbzT1rxnqeamJgoDzO3E9606 intact-crc:C9DAE0378173D659|rigid:p+hoVZEXC/YwQgOaWBbqV7kUUZU false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q2WGJ6 uniprotkb:Q8IVD9 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396177|imex:IM-22301-1622 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1 refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:842FE6EB64D242D4|rigid:3JbNGj4yRVZEMNmkSsdW8oOyGAA false flag tag:c-c|necessary binding region:139-266(IPR011705) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q2WGJ6 uniprotkb:P08238 intact:EBI-6426443|ensembl:ENSP00000321475|ensembl:ENSP00000508228|uniprotkb:A0PK12 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:klh38_human(display_long)|uniprotkb:KLHL38(gene name)|psi-mi:KLHL38(display_short)|uniprotkb:C8orfK36(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396177|imex:IM-22301-1622 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000175946(gene)|ensembl:ENST00000325995(transcript)|ensembl:ENST00000684634(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030568|refseq:NP_001075144.2|refseq:XP_005250958.1 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:rlg+IPIdEhu2LCAxchlall1J6PE9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:842FE6EB64D242D4|rigid:3JbNGj4yRVZEMNmkSsdW8oOyGAA false flag tag:c-c|necessary binding region:139-266(IPR011705) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9H3U1 uniprotkb:P08238 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396165|imex:IM-22301-1620 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:Supplementary fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:926AE12E95AB6943|rigid:fuQYveo2NTIpSqQMKsrHiAgj3aQ false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10398 uniprotkb:P08238 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396217|imex:IM-22301-1626 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:8A6D126A4D07EC89|rigid:7ZvdGr5tTe/GrJDynBFAhSLP5RQ false flag tag:c-c|sufficient binding region:278-606(IPR000719) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10398 uniprotkb:Q16543 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396217|imex:IM-22301-1626 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737 - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:8A6D126A4D07EC89|rigid:7ZvdGr5tTe/GrJDynBFAhSLP5RQ false flag tag:c-c|sufficient binding region:278-606(IPR000719) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UL18 uniprotkb:P08238 intact:EBI-527363|uniprotkb:Q5TA57|uniprotkb:Q6P4S0|ensembl:ENSP00000362300|ensembl:ENSP00000501450 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:ago1_human(display_long)|uniprotkb:AGO1(gene name)|psi-mi:AGO1(display_short)|uniprotkb:Argonaute RISC catalytic component 1(gene name synonym)|uniprotkb:EIF2C1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2C 1(gene name synonym)|uniprotkb:Putative RNA-binding protein Q99(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396153|imex:IM-22301-1618 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29193N|refseq:NP_036331.1|ensembl:ENSG00000092847(gene)|ensembl:ENST00000373204(transcript)|ensembl:ENST00000674304(transcript)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016442"(RISC complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR003165(Stem cell self-renewal protein Piwi)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014811(Region of unknown function DUF1785)|interpro:IPR032472|interpro:IPR032473|interpro:IPR032474|interpro:IPR036085|interpro:IPR036397|mint:Q9UL18|rcsb pdb:1SI2|rcsb pdb:1SI3|rcsb pdb:4KRE|rcsb pdb:4KRF|rcsb pdb:4KXT|rcsb pdb:5W6V|reactome:R-HSA-1912408|reactome:R-HSA-203927|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-4086398|reactome:R-HSA-426486|reactome:R-HSA-426496|reactome:R-HSA-5578749|reactome:R-HSA-5628897|reactome:R-HSA-5687128|reactome:R-HSA-8853884|reactome:R-HSA-8934593|reactome:R-HSA-8936459|reactome:R-HSA-8943723|reactome:R-HSA-8948700|reactome:R-HSA-8986944|reactome:R-HSA-9018519|reactome:R-HSA-9022692|reactome:R-HSA-9029569|refseq:NP_001304051.1|refseq:NP_001304052.1 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:Supplementary fig 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:l/WmIsnfJjifEOoxOyG9zDo2ljQ9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:926C2681D2BFEDBE|rigid:ZzIt0bKdk44ARWd1cqQhxUr76U8 false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08238 uniprotkb:P10398 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396147|imex:IM-22301-1617 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N - - - figure legend:Supplementary fig 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 intact-crc:5EFC3E17D103ECD5|rigid:xNOMcpwQNbDNBlCs9DiATmR98rY false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10398 uniprotkb:P08238 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396708|imex:IM-22301-1627 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:Supplementary fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:476A4D8B3C50C3B5|rigid:7ZvdGr5tTe/GrJDynBFAhSLP5RQ false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10398 uniprotkb:Q16543 intact:EBI-365961|uniprotkb:P07557|uniprotkb:Q5H9B3|intact:EBI-28988863|ensembl:ENSP00000366244|uniprotkb:Q5H9B2 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:araf_human(display_long)|uniprotkb:ARAF(gene name)|psi-mi:ARAF(display_short)|uniprotkb:PKS(gene name synonym)|uniprotkb:PKS2(gene name synonym)|uniprotkb:ARAF1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf-1(gene name synonym)|uniprotkb:Proto-oncogene Pks(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396708|imex:IM-22301-1627 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000078061(gene)|ensembl:ENST00000377045(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P10398|rcsb pdb:2MSE|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|rcsb pdb:1WXM|refseq:NP_001645.1|refseq:XP_011542210.1|refseq:NP_001243125.1|ensembl:ENST00000377039|ensembl:ENSP00000366238|ensembl:ENSP00000366244|refseq:NP_001243126.1|dip:DIP-31374N refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737 - - - figure legend:Supplementary fig 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:WRtbdrEuDxNkA6jRRxvapodFcUE9606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:476A4D8B3C50C3B5|rigid:7ZvdGr5tTe/GrJDynBFAhSLP5RQ false flag tag:c-c ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14318 uniprotkb:P08238 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396735|imex:IM-22301-1628 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:Supplementary fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:60E8EDA4DAF3EDCE|rigid:wi7OtOygqlf/gpbDnkolC0cyHbU false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKC9 uniprotkb:P08238 intact:EBI-724253|ensembl:ENSP00000417601|uniprotkb:Q6IAN3|uniprotkb:Q9Y3Y9|uniprotkb:Q9NVQ8|uniprotkb:Q9UK27|uniprotkb:Q9UKA5|uniprotkb:B4DQV0|uniprotkb:E9PD06 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 psi-mi:fbxl2_human(display_long)|uniprotkb:F-box and leucine-rich repeat protein 2(gene name synonym)|uniprotkb:F-box protein FBL2/FBL3(gene name synonym)|uniprotkb:FBXL2(gene name)|psi-mi:FBXL2(display_short)|uniprotkb:FBL2(gene name synonym)|uniprotkb:FBL3(gene name synonym) psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396207|imex:IM-22301-1625 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000153558(gene)|ensembl:ENST00000484457(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|interpro:IPR001611(Leucine-rich repeat)|refseq:NP_001165184.1|refseq:NP_036289.3|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|rcsb pdb:6O60 ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/04/24 rogid:BkHs0ftn8BdTq/UmoduZueg5C649606 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 intact-crc:4B20BE6E0AA70E86|rigid:Ry+98oCgFDizL5tajQt3q48GCj0 false flag tag:c-c|sufficient binding region:59-423(IPR006553) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKC9 uniprotkb:Q9Y2Z0 intact:EBI-724253|ensembl:ENSP00000417601|uniprotkb:Q6IAN3|uniprotkb:Q9Y3Y9|uniprotkb:Q9NVQ8|uniprotkb:Q9UK27|uniprotkb:Q9UKA5|uniprotkb:B4DQV0|uniprotkb:E9PD06 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:fbxl2_human(display_long)|uniprotkb:F-box and leucine-rich repeat protein 2(gene name synonym)|uniprotkb:F-box protein FBL2/FBL3(gene name synonym)|uniprotkb:FBXL2(gene name)|psi-mi:FBXL2(display_short)|uniprotkb:FBL2(gene name synonym)|uniprotkb:FBL3(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396207|imex:IM-22301-1625 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000153558(gene)|ensembl:ENST00000484457(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|interpro:IPR001611(Leucine-rich repeat)|refseq:NP_001165184.1|refseq:NP_036289.3|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|rcsb pdb:6O60 reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N - - - figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2015/04/24 rogid:BkHs0ftn8BdTq/UmoduZueg5C649606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:4B20BE6E0AA70E86|rigid:Ry+98oCgFDizL5tajQt3q48GCj0 false flag tag:c-c|sufficient binding region:59-423(IPR006553) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P08238 uniprotkb:Q8IV38 intact:EBI-352572|ensembl:ENSP00000325875|ensembl:ENSP00000360609|ensembl:ENSP00000360709|ensembl:ENSP00000481908|uniprotkb:Q5T9W7|uniprotkb:Q9NQW0|uniprotkb:Q9NTK6|uniprotkb:B2R5P0 intact:EBI-9393876|uniprotkb:A4D124|uniprotkb:Q96BL3|uniprotkb:Q659G1|ensembl:ENSP00000303570 psi-mi:hs90b_human(display_long)|uniprotkb:HSP90AB1(gene name)|psi-mi:HSP90AB1(display_short)|uniprotkb:HSP90B(gene name synonym)|uniprotkb:HSPC2(gene name synonym)|uniprotkb:HSPCB(gene name synonym)|uniprotkb:Heat shock 84 kDa(gene name synonym) psi-mi:anky2_human(display_long)|uniprotkb:ANKMY2(gene name)|psi-mi:ANKMY2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taipale et al. (2014) pubmed:25036637|imex:IM-22301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9396159|imex:IM-22301-1619 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000096384(gene)|ensembl:ENST00000353801(transcript)|ensembl:ENST00000371554(transcript)|ensembl:ENST00000371646(transcript)|ensembl:ENST00000620073(transcript)|go:"GO:0001890"(placenta development)|go:"GO:0002134"(UTP binding)|go:"GO:0002135"(CTP binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_031381.2|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009651"(response to salt stress)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017098"(sulfonylurea receptor binding)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030911"(TPR domain binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031526"(brush border membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032564"(dATP binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:1901389"(negative regulation of transforming growth factor beta activation)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903827"|go:"GO:1904031"(positive regulation of cyclin-dependent protein kinase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|go:"GO:1990913"(sperm head plasma membrane)|go:"GO:1990917"(ooplasm)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P08238|rcsb pdb:1QZ2|rcsb pdb:1UYM|rcsb pdb:2L6J|rcsb pdb:3FWV|rcsb pdb:3NMQ|rcsb pdb:3PRY|rcsb pdb:3UQ3|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5UC4|rcsb pdb:5UCH|rcsb pdb:5UCI|rcsb pdb:5UCJ|rcsb pdb:6N8W|rcsb pdb:6N8Y|reactome:R-HSA-168928|reactome:R-HSA-2029482|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-399954|reactome:R-HSA-5336415|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8852276|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9013418|reactome:R-HSA-9018519|reactome:R-HSA-9613829|reactome:R-HSA-9660826|reactome:R-HSA-9679191|refseq:NP_001258898.1|refseq:NP_001258899.1|refseq:NP_001258900.1|dip:DIP-413N refseq:NP_064715.1|ensembl:ENSG00000106524(gene)|ensembl:ENST00000306999(transcript)|go:"GO:0005929"(cilium)|go:"GO:0019899"(enzyme binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR020683|interpro:IPR036770 - - - figure legend:Supplementary fig 3E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2014/03/06 2014/10/16 rogid:wOsW7C10v2oMsM+REE38K6PAan09606 rogid:Fw1jLmLiX4rE+TuKDLF96LFmORo9606 intact-crc:C9DC268120E3B759|rigid:6KhweiRe1ykL8Zy7+PSVjJMgdyk false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)