#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13586	uniprotkb:Q96D31	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631617|imex:IM-22938-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	-	-	-	figure legend:f3b f3c f3d f3f f3g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/23	2014/10/16	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:DE40BD1DFCEF8D08|rigid:vcTi++PINtFYRSz2u8Diz54La3s	false	ha tag:?-?	tandem tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96D31	uniprotkb:Q96D31	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631468|imex:IM-22938-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	-	-	-	figure legend:f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/23	2014/10/16	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	intact-crc:360C582A7E40D59F|rigid:RAeELzDuSgIcJ2VVZh84fTE8cU4	false	his tag:?-?	his tag:?-?	6	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13586	uniprotkb:Q13586	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631566|imex:IM-22938-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:f4|comment:"A low-magnification AFM image of the isolated protein  (Fig. 4B) shows single small particles, as well as doublets (arrowheads), and string-like  structures (arrow) similar to those described above. Zoomed images of these two types of  multimeric structures are shown in Fig. 4C. A frequency distribution of the volumes of the  STIM1 particles (Fig. 4D)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/23	2014/10/16	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	intact-crc:D604D8D6BD9E48BD|rigid:184IV+takMKeSfTZ+SGdNeeWiPQ	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13586	uniprotkb:Q13586	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0872"(atomic force microscopy)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631598|imex:IM-22938-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	-	-	-	figure legend:f4|comment:"A low-magnification AFM image of the isolated protein  (Fig. 4B) shows single small particles, as well as doublets (arrowheads), and string-like  structures (arrow) similar to those described above. Zoomed images of these two types of  multimeric structures are shown in Fig. 4C. A frequency distribution of the volumes of the  STIM1 particles (Fig. 4D)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/23	2014/10/16	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	intact-crc:248A52FCBFD96AB9|rigid:L1wBeQgGonyuASFyhXKpOEAJUb0	false	ha tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96D31	uniprotkb:Q13586	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631480|imex:IM-22938-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:f2a|comment:"Cells were next co-transfected with DNA encoding Orai1-Myc/His and HA-STIM1. The  localization of the two proteins, with and without thapsigargin (5 M) treatment, was  determined by immunofluorescence analysis of saponin-permeabilized cells. In control cells,  Orai1 was seen predominantly at the plasma membrane, whereas STIM1 was found in a  reticular pattern throughout the cell cytoplasm, consistent with an ER localization (Fig. 2A).  By contrast, in thapsigargin-treated cells, the STIM1 and Orai1 signals overlapped  extensively, consistent with the translocation of STIM1 to sites beneath the plasma  membrane"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tsa201)|taxid:9606(Homo sapiens subclone of human embryonic kidney 293 cell line that expresses simian virus 40 T antigen)	-	2014/06/23	2014/10/16	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	intact-crc:547CB9DDA36FE35A|rigid:vcTi++PINtFYRSz2u8Diz54La3s	false	tandem tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q96D31	uniprotkb:Q13586	intact:EBI-2291476|uniprotkb:Q3MHV3|uniprotkb:Q6DHX2|uniprotkb:Q96BP7|uniprotkb:Q96K71|ensembl:ENSP00000482568	intact:EBI-448878|uniprotkb:Q8N382|ensembl:ENSP00000300737|uniprotkb:E9PQJ4	psi-mi:crcm1_human(display_long)|uniprotkb:ORAI1(gene name)|psi-mi:ORAI1(display_short)|uniprotkb:CRACM1(gene name synonym)|uniprotkb:TMEM142A(gene name synonym)|uniprotkb:Protein orai-1(gene name synonym)|uniprotkb:Transmembrane protein 142A(gene name synonym)	psi-mi:stim1_human(display_long)|uniprotkb:STIM1(gene name)|psi-mi:STIM1(display_short)|uniprotkb:GOK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Balasuriya et al. (2014)	pubmed:24996186|imex:IM-22938	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9631553|imex:IM-22938-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116179.2|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR012446(Protein of unknown function DUF1650)|interpro:IPR038350|rcsb pdb:2MAK|rcsb pdb:4EHQ|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|ensembl:ENSG00000276045(gene)|ensembl:ENST00000617316(transcript)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045121"(membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070509"(calcium ion import)|dip:DIP-46289N	refseq:NP_003147.2|ensembl:ENSG00000167323(gene)|ensembl:ENST00000300737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002115"(store-operated calcium entry)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032541"(cortical endoplasmic reticulum)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070166"(enamel mineralization)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030463|interpro:IPR032393|interpro:IPR037608|interpro:IPR037609|rcsb pdb:2K60|rcsb pdb:2MAJ|rcsb pdb:2MAK|rcsb pdb:3TEQ|rcsb pdb:4O9B|rcsb pdb:6YEL|reactome:R-HSA-139853|reactome:R-HSA-5578775|reactome:R-HSA-983695|refseq:NP_001264891.1|dip:DIP-31121N	go:"GO:0005886"(plasma membrane)	-	-	figure legend:f2b f3a|comment:"Co-transfected cells, either untreated or thapsigargin-treated, were  solubilized, and the detergent extracts were subjected to anti-Myc immunoprecipitation  followed by immunoblotting with anti-Myc (Orai1) and anti-HA (STIM1) antibodies. Orai1  was present in both samples, as expected (Fig. 2B), whereas STIM1 was coimmunopreciptated  only from the extract of thapsigargin-treated cells, indicating that STIM1  associates with Orai1 only after store depletion."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tsa201)|taxid:9606(Homo sapiens subclone of human embryonic kidney 293 cell line that expresses simian virus 40 T antigen)	-	2014/06/23	2014/10/16	rogid:VXcTrF/8sZA01XGUFZwvu75L7Kw9606	rogid:GQh8kgCwqrcx7VtJdv63pW1eg/U9606	intact-crc:042CBB685810364E|rigid:vcTi++PINtFYRSz2u8Diz54La3s	false	tandem tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)